id sid tid token lemma pos work_arndyvdyobgtlpeh4rho7pywpi 1 1 doi:10.1086/318202 doi:10.1086/318202 NNP work_arndyvdyobgtlpeh4rho7pywpi 1 2 Am Am NNP work_arndyvdyobgtlpeh4rho7pywpi 1 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 2 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 2 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 2 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 3 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 3 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 4 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 4 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 4 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 4 4 334 334 CD work_arndyvdyobgtlpeh4rho7pywpi 4 5 The The NNP work_arndyvdyobgtlpeh4rho7pywpi 4 6 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 4 7 Basis Basis NNP work_arndyvdyobgtlpeh4rho7pywpi 4 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 4 9 3-Methylcrotonylglycinuria 3-methylcrotonylglycinuria CD work_arndyvdyobgtlpeh4rho7pywpi 4 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 4 11 a a DT work_arndyvdyobgtlpeh4rho7pywpi 4 12 Disorder Disorder NNP work_arndyvdyobgtlpeh4rho7pywpi 4 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 4 14 Leucine Leucine NNP work_arndyvdyobgtlpeh4rho7pywpi 4 15 Catabolism Catabolism NNP work_arndyvdyobgtlpeh4rho7pywpi 4 16 M. M. NNP work_arndyvdyobgtlpeh4rho7pywpi 4 17 Esther Esther NNP work_arndyvdyobgtlpeh4rho7pywpi 4 18 Gallardo,1,2 Gallardo,1,2 NNPS work_arndyvdyobgtlpeh4rho7pywpi 4 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 4 20 * * NFP work_arndyvdyobgtlpeh4rho7pywpi 4 21 Lourdes Lourdes NNP work_arndyvdyobgtlpeh4rho7pywpi 4 22 R. R. NNP work_arndyvdyobgtlpeh4rho7pywpi 4 23 Desviat,3 Desviat,3 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 4 25 * * NFP work_arndyvdyobgtlpeh4rho7pywpi 4 26 José José NNP work_arndyvdyobgtlpeh4rho7pywpi 4 27 M. M. NNP work_arndyvdyobgtlpeh4rho7pywpi 4 28 Rodrı́guez,1 Rodrı́guez,1 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 4 30 * * NFP work_arndyvdyobgtlpeh4rho7pywpi 4 31 Jorge Jorge NNP work_arndyvdyobgtlpeh4rho7pywpi 4 32 Esparza Esparza NNP work_arndyvdyobgtlpeh4rho7pywpi 4 33 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 4 34 Gordillo,1,2 Gordillo,1,2 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 35 Celia Celia NNP work_arndyvdyobgtlpeh4rho7pywpi 4 36 Pérez pérez NN work_arndyvdyobgtlpeh4rho7pywpi 4 37 - - : work_arndyvdyobgtlpeh4rho7pywpi 4 38 Cerdá,3 cerdá,3 NN work_arndyvdyobgtlpeh4rho7pywpi 4 39 Belén Belén NNP work_arndyvdyobgtlpeh4rho7pywpi 4 40 Pérez,3 pérez,3 CD work_arndyvdyobgtlpeh4rho7pywpi 4 41 Pilar Pilar NNP work_arndyvdyobgtlpeh4rho7pywpi 4 42 Rodrı́guez Rodrı́guez NNP work_arndyvdyobgtlpeh4rho7pywpi 4 43 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 4 44 Pombo,3 Pombo,3 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 45 Olga Olga NNP work_arndyvdyobgtlpeh4rho7pywpi 4 46 Criado,1 Criado,1 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 47 Raul Raul NNP work_arndyvdyobgtlpeh4rho7pywpi 4 48 Sanz,2 Sanz,2 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 49 D. D. NNP work_arndyvdyobgtlpeh4rho7pywpi 4 50 Holmes Holmes NNP work_arndyvdyobgtlpeh4rho7pywpi 4 51 Morton,4 Morton,4 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 52 K. K. NNP work_arndyvdyobgtlpeh4rho7pywpi 4 53 Michael Michael NNP work_arndyvdyobgtlpeh4rho7pywpi 4 54 Gibson,5 Gibson,5 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 55 Thuy Thuy NNP work_arndyvdyobgtlpeh4rho7pywpi 4 56 P. P. NNP work_arndyvdyobgtlpeh4rho7pywpi 4 57 Le,6 Le,6 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 58 Antonia Antonia NNP work_arndyvdyobgtlpeh4rho7pywpi 4 59 Ribes,7 Ribes,7 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 60 Santiago Santiago NNP work_arndyvdyobgtlpeh4rho7pywpi 4 61 Rodrı́guez Rodrı́guez NNP work_arndyvdyobgtlpeh4rho7pywpi 4 62 de de NN work_arndyvdyobgtlpeh4rho7pywpi 4 63 Córdoba,1,2 córdoba,1,2 JJ work_arndyvdyobgtlpeh4rho7pywpi 4 64 Magdalena Magdalena NNP work_arndyvdyobgtlpeh4rho7pywpi 4 65 Ugarte,3 Ugarte,3 NNP work_arndyvdyobgtlpeh4rho7pywpi 4 66 and and CC work_arndyvdyobgtlpeh4rho7pywpi 4 67 Miguel Miguel NNP work_arndyvdyobgtlpeh4rho7pywpi 4 68 Á. Á. NNP work_arndyvdyobgtlpeh4rho7pywpi 5 1 Peñalva1 Peñalva1 NNP work_arndyvdyobgtlpeh4rho7pywpi 5 2 1Centro 1Centro NNP work_arndyvdyobgtlpeh4rho7pywpi 5 3 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 5 4 Investigaciones Investigaciones NNP work_arndyvdyobgtlpeh4rho7pywpi 5 5 Biológicas Biológicas NNP work_arndyvdyobgtlpeh4rho7pywpi 5 6 CSIC CSIC NNP work_arndyvdyobgtlpeh4rho7pywpi 5 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 8 2Fundación 2fundación ADD work_arndyvdyobgtlpeh4rho7pywpi 5 9 Jiménez Jiménez NNP work_arndyvdyobgtlpeh4rho7pywpi 5 10 Dı́az Dı́az NNP work_arndyvdyobgtlpeh4rho7pywpi 5 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 5 13 3Centro 3Centro NNP work_arndyvdyobgtlpeh4rho7pywpi 5 14 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 5 15 Biologı́a Biologı́a NNP work_arndyvdyobgtlpeh4rho7pywpi 5 16 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 5 17 CSIC CSIC NNP work_arndyvdyobgtlpeh4rho7pywpi 5 18 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 5 19 UAM UAM NNP work_arndyvdyobgtlpeh4rho7pywpi 5 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 21 Universidad Universidad NNP work_arndyvdyobgtlpeh4rho7pywpi 5 22 Autónoma Autónoma NNP work_arndyvdyobgtlpeh4rho7pywpi 5 23 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 5 24 Madrid Madrid NNP work_arndyvdyobgtlpeh4rho7pywpi 5 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 26 Madrid Madrid NNP work_arndyvdyobgtlpeh4rho7pywpi 5 27 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 5 28 4Clinic 4Clinic NNP work_arndyvdyobgtlpeh4rho7pywpi 5 29 for for IN work_arndyvdyobgtlpeh4rho7pywpi 5 30 Special Special NNP work_arndyvdyobgtlpeh4rho7pywpi 5 31 Children Children NNP work_arndyvdyobgtlpeh4rho7pywpi 5 32 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 33 Strasburg Strasburg NNP work_arndyvdyobgtlpeh4rho7pywpi 5 34 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 35 PA pa NN work_arndyvdyobgtlpeh4rho7pywpi 5 36 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 5 37 5Department 5department CD work_arndyvdyobgtlpeh4rho7pywpi 5 38 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 39 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 5 40 and and CC work_arndyvdyobgtlpeh4rho7pywpi 5 41 Medical Medical NNP work_arndyvdyobgtlpeh4rho7pywpi 5 42 Genetics Genetics NNPS work_arndyvdyobgtlpeh4rho7pywpi 5 43 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 44 Oregon Oregon NNP work_arndyvdyobgtlpeh4rho7pywpi 5 45 Health Health NNP work_arndyvdyobgtlpeh4rho7pywpi 5 46 Sciences Sciences NNPS work_arndyvdyobgtlpeh4rho7pywpi 5 47 University University NNP work_arndyvdyobgtlpeh4rho7pywpi 5 48 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 49 Portland Portland NNP work_arndyvdyobgtlpeh4rho7pywpi 5 50 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 5 51 6Department 6Department NNP work_arndyvdyobgtlpeh4rho7pywpi 5 52 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 53 Pediatrics Pediatrics NNPS work_arndyvdyobgtlpeh4rho7pywpi 5 54 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 55 University University NNP work_arndyvdyobgtlpeh4rho7pywpi 5 56 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 57 California California NNP work_arndyvdyobgtlpeh4rho7pywpi 5 58 San San NNP work_arndyvdyobgtlpeh4rho7pywpi 5 59 Diego Diego NNP work_arndyvdyobgtlpeh4rho7pywpi 5 60 School School NNP work_arndyvdyobgtlpeh4rho7pywpi 5 61 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 62 Medicine Medicine NNP work_arndyvdyobgtlpeh4rho7pywpi 5 63 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 64 La La NNP work_arndyvdyobgtlpeh4rho7pywpi 5 65 Jolla Jolla NNP work_arndyvdyobgtlpeh4rho7pywpi 5 66 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 5 67 and and CC work_arndyvdyobgtlpeh4rho7pywpi 5 68 7Institut 7Institut NNP work_arndyvdyobgtlpeh4rho7pywpi 5 69 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 5 70 Bioquı́mica Bioquı́mica NNP work_arndyvdyobgtlpeh4rho7pywpi 5 71 Clı̀nica Clı̀nica NNP work_arndyvdyobgtlpeh4rho7pywpi 5 72 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 73 Corporació Corporació NNP work_arndyvdyobgtlpeh4rho7pywpi 5 74 Sanitària sanitària CD work_arndyvdyobgtlpeh4rho7pywpi 5 75 Clı́nic Clı́nic NNP work_arndyvdyobgtlpeh4rho7pywpi 5 76 , , , work_arndyvdyobgtlpeh4rho7pywpi 5 77 Barcelona Barcelona NNP work_arndyvdyobgtlpeh4rho7pywpi 5 78 3-Methylcrotonylglycinuria 3-methylcrotonylglycinuria CD work_arndyvdyobgtlpeh4rho7pywpi 5 79 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 5 80 an an DT work_arndyvdyobgtlpeh4rho7pywpi 5 81 inborn inborn JJ work_arndyvdyobgtlpeh4rho7pywpi 5 82 error error NN work_arndyvdyobgtlpeh4rho7pywpi 5 83 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 84 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 5 85 catabolism catabolism NN work_arndyvdyobgtlpeh4rho7pywpi 5 86 and and CC work_arndyvdyobgtlpeh4rho7pywpi 5 87 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 5 88 a a DT work_arndyvdyobgtlpeh4rho7pywpi 5 89 recessive recessive JJ work_arndyvdyobgtlpeh4rho7pywpi 5 90 pattern pattern NN work_arndyvdyobgtlpeh4rho7pywpi 5 91 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 92 inheritance inheritance NN work_arndyvdyobgtlpeh4rho7pywpi 5 93 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 5 94 results result VBZ work_arndyvdyobgtlpeh4rho7pywpi 5 95 from from IN work_arndyvdyobgtlpeh4rho7pywpi 5 96 the the DT work_arndyvdyobgtlpeh4rho7pywpi 5 97 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 5 98 of of IN work_arndyvdyobgtlpeh4rho7pywpi 5 99 3-methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 5 100 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 5 101 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 5 102 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 5 103 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 5 104 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 5 105 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 5 106 . . . work_arndyvdyobgtlpeh4rho7pywpi 6 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 6 2 introduction introduction NN work_arndyvdyobgtlpeh4rho7pywpi 6 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 6 4 tandem tandem NNP work_arndyvdyobgtlpeh4rho7pywpi 6 5 mass mass JJ work_arndyvdyobgtlpeh4rho7pywpi 6 6 spec- spec- NNP work_arndyvdyobgtlpeh4rho7pywpi 6 7 trometry trometry NN work_arndyvdyobgtlpeh4rho7pywpi 6 8 in in IN work_arndyvdyobgtlpeh4rho7pywpi 6 9 newborn newborn JJ work_arndyvdyobgtlpeh4rho7pywpi 6 10 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 6 11 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 6 12 revealed reveal VBN work_arndyvdyobgtlpeh4rho7pywpi 6 13 an an DT work_arndyvdyobgtlpeh4rho7pywpi 6 14 unexpectedly unexpectedly RB work_arndyvdyobgtlpeh4rho7pywpi 6 15 high high JJ work_arndyvdyobgtlpeh4rho7pywpi 6 16 incidence incidence NN work_arndyvdyobgtlpeh4rho7pywpi 6 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 6 18 this this DT work_arndyvdyobgtlpeh4rho7pywpi 6 19 disorder disorder NN work_arndyvdyobgtlpeh4rho7pywpi 6 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 6 21 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 6 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 6 23 in in IN work_arndyvdyobgtlpeh4rho7pywpi 6 24 certain certain JJ work_arndyvdyobgtlpeh4rho7pywpi 6 25 areas area NNS work_arndyvdyobgtlpeh4rho7pywpi 6 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 6 27 appears appear VBZ work_arndyvdyobgtlpeh4rho7pywpi 6 28 to to TO work_arndyvdyobgtlpeh4rho7pywpi 6 29 be be VB work_arndyvdyobgtlpeh4rho7pywpi 6 30 the the DT work_arndyvdyobgtlpeh4rho7pywpi 6 31 most most RBS work_arndyvdyobgtlpeh4rho7pywpi 6 32 frequent frequent JJ work_arndyvdyobgtlpeh4rho7pywpi 6 33 organic organic JJ work_arndyvdyobgtlpeh4rho7pywpi 6 34 aciduria aciduria NN work_arndyvdyobgtlpeh4rho7pywpi 6 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 7 1 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 7 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 7 3 an an DT work_arndyvdyobgtlpeh4rho7pywpi 7 4 heteromeric heteromeric NN work_arndyvdyobgtlpeh4rho7pywpi 7 5 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 7 6 consisting consist VBG work_arndyvdyobgtlpeh4rho7pywpi 7 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 7 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 7 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 7 10 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 7 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 7 12 containing containing NN work_arndyvdyobgtlpeh4rho7pywpi 7 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 7 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 7 15 b b NN work_arndyvdyobgtlpeh4rho7pywpi 7 16 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 7 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 7 18 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 7 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 7 20 only only JJ work_arndyvdyobgtlpeh4rho7pywpi 7 21 one one CD work_arndyvdyobgtlpeh4rho7pywpi 7 22 of of IN work_arndyvdyobgtlpeh4rho7pywpi 7 23 the the DT work_arndyvdyobgtlpeh4rho7pywpi 7 24 four four CD work_arndyvdyobgtlpeh4rho7pywpi 7 25 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 7 26 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 7 27 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 7 28 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 7 29 known know VBN work_arndyvdyobgtlpeh4rho7pywpi 7 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 7 31 humans human NNS work_arndyvdyobgtlpeh4rho7pywpi 7 32 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 7 33 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 7 34 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 7 35 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 7 36 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 7 37 not not RB work_arndyvdyobgtlpeh4rho7pywpi 7 38 yet yet RB work_arndyvdyobgtlpeh4rho7pywpi 7 39 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 7 40 characterized characterize VBN work_arndyvdyobgtlpeh4rho7pywpi 7 41 , , , work_arndyvdyobgtlpeh4rho7pywpi 7 42 precluding preclude VBG work_arndyvdyobgtlpeh4rho7pywpi 7 43 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 7 44 studies study NNS work_arndyvdyobgtlpeh4rho7pywpi 7 45 of of IN work_arndyvdyobgtlpeh4rho7pywpi 7 46 this this DT work_arndyvdyobgtlpeh4rho7pywpi 7 47 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 7 48 . . . work_arndyvdyobgtlpeh4rho7pywpi 8 1 Here here RB work_arndyvdyobgtlpeh4rho7pywpi 8 2 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 8 3 report report VBP work_arndyvdyobgtlpeh4rho7pywpi 8 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 8 5 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 8 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 8 7 at at IN work_arndyvdyobgtlpeh4rho7pywpi 8 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 8 9 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 8 10 level level NN work_arndyvdyobgtlpeh4rho7pywpi 8 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 8 12 at at IN work_arndyvdyobgtlpeh4rho7pywpi 8 13 the the DT work_arndyvdyobgtlpeh4rho7pywpi 8 14 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 8 15 level level NN work_arndyvdyobgtlpeh4rho7pywpi 8 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 8 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 8 18 both both CC work_arndyvdyobgtlpeh4rho7pywpi 8 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 8 20 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 8 21 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 8 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 8 23 the the DT work_arndyvdyobgtlpeh4rho7pywpi 8 24 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 8 25 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 8 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 8 27 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 8 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 8 29 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 8 30 and and CC work_arndyvdyobgtlpeh4rho7pywpi 8 31 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 8 32 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 8 33 , , , work_arndyvdyobgtlpeh4rho7pywpi 8 34 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 8 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 9 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 9 2 19-exon 19-exon CD work_arndyvdyobgtlpeh4rho7pywpi 9 3 MCCA mcca NN work_arndyvdyobgtlpeh4rho7pywpi 9 4 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 9 5 maps map NNS work_arndyvdyobgtlpeh4rho7pywpi 9 6 to to IN work_arndyvdyobgtlpeh4rho7pywpi 9 7 3q25 3q25 CD work_arndyvdyobgtlpeh4rho7pywpi 9 8 - - SYM work_arndyvdyobgtlpeh4rho7pywpi 9 9 27 27 CD work_arndyvdyobgtlpeh4rho7pywpi 9 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 9 11 encodes encode NNS work_arndyvdyobgtlpeh4rho7pywpi 9 12 a a DT work_arndyvdyobgtlpeh4rho7pywpi 9 13 725-residue 725-residue CD work_arndyvdyobgtlpeh4rho7pywpi 9 14 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 9 15 with with IN work_arndyvdyobgtlpeh4rho7pywpi 9 16 a a DT work_arndyvdyobgtlpeh4rho7pywpi 9 17 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 9 18 attachment attachment NN work_arndyvdyobgtlpeh4rho7pywpi 9 19 site site NN work_arndyvdyobgtlpeh4rho7pywpi 9 20 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 9 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 9 22 17-exon 17-exon CD work_arndyvdyobgtlpeh4rho7pywpi 9 23 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 9 24 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 9 25 maps map NNS work_arndyvdyobgtlpeh4rho7pywpi 9 26 to to IN work_arndyvdyobgtlpeh4rho7pywpi 9 27 5q12-q13 5q12-q13 VB work_arndyvdyobgtlpeh4rho7pywpi 9 28 and and CC work_arndyvdyobgtlpeh4rho7pywpi 9 29 encodes encode VBZ work_arndyvdyobgtlpeh4rho7pywpi 9 30 a a DT work_arndyvdyobgtlpeh4rho7pywpi 9 31 563-residue 563-residue CD work_arndyvdyobgtlpeh4rho7pywpi 9 32 polypeptide polypeptide NN work_arndyvdyobgtlpeh4rho7pywpi 9 33 . . . work_arndyvdyobgtlpeh4rho7pywpi 10 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 10 2 show show VBP work_arndyvdyobgtlpeh4rho7pywpi 10 3 that that IN work_arndyvdyobgtlpeh4rho7pywpi 10 4 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 10 5 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 10 6 causing cause VBG work_arndyvdyobgtlpeh4rho7pywpi 10 7 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 10 8 can can MD work_arndyvdyobgtlpeh4rho7pywpi 10 9 be be VB work_arndyvdyobgtlpeh4rho7pywpi 10 10 classified classify VBN work_arndyvdyobgtlpeh4rho7pywpi 10 11 into into IN work_arndyvdyobgtlpeh4rho7pywpi 10 12 two two CD work_arndyvdyobgtlpeh4rho7pywpi 10 13 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 10 14 groups group NNS work_arndyvdyobgtlpeh4rho7pywpi 10 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 10 16 denoted denote VBN work_arndyvdyobgtlpeh4rho7pywpi 10 17 “ " `` work_arndyvdyobgtlpeh4rho7pywpi 10 18 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 10 19 ” " '' work_arndyvdyobgtlpeh4rho7pywpi 10 20 and and CC work_arndyvdyobgtlpeh4rho7pywpi 10 21 “ " `` work_arndyvdyobgtlpeh4rho7pywpi 10 22 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 10 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 10 24 ” " '' work_arndyvdyobgtlpeh4rho7pywpi 10 25 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 10 26 detected detect VBD work_arndyvdyobgtlpeh4rho7pywpi 10 27 two two CD work_arndyvdyobgtlpeh4rho7pywpi 10 28 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 10 29 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 10 30 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 10 31 in in IN work_arndyvdyobgtlpeh4rho7pywpi 10 32 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 10 33 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 10 34 , , , work_arndyvdyobgtlpeh4rho7pywpi 10 35 one one CD work_arndyvdyobgtlpeh4rho7pywpi 10 36 of of IN work_arndyvdyobgtlpeh4rho7pywpi 10 37 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 10 38 leads lead VBZ work_arndyvdyobgtlpeh4rho7pywpi 10 39 to to IN work_arndyvdyobgtlpeh4rho7pywpi 10 40 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 10 41 of of IN work_arndyvdyobgtlpeh4rho7pywpi 10 42 biotinylated biotinylated JJ work_arndyvdyobgtlpeh4rho7pywpi 10 43 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 10 44 . . . work_arndyvdyobgtlpeh4rho7pywpi 11 1 Two two CD work_arndyvdyobgtlpeh4rho7pywpi 11 2 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 11 3 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 11 4 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 11 5 and and CC work_arndyvdyobgtlpeh4rho7pywpi 11 6 one one CD work_arndyvdyobgtlpeh4rho7pywpi 11 7 splicing splice VBG work_arndyvdyobgtlpeh4rho7pywpi 11 8 defect defect JJ work_arndyvdyobgtlpeh4rho7pywpi 11 9 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 11 10 leading lead VBG work_arndyvdyobgtlpeh4rho7pywpi 11 11 to to IN work_arndyvdyobgtlpeh4rho7pywpi 11 12 early early JJ work_arndyvdyobgtlpeh4rho7pywpi 11 13 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 11 14 truncation truncation NN work_arndyvdyobgtlpeh4rho7pywpi 11 15 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 11 16 found find VBN work_arndyvdyobgtlpeh4rho7pywpi 11 17 in in IN work_arndyvdyobgtlpeh4rho7pywpi 11 18 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 11 19 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 11 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 12 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 12 2 fourth fourth JJ work_arndyvdyobgtlpeh4rho7pywpi 12 3 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 12 4 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 12 5 also also RB work_arndyvdyobgtlpeh4rho7pywpi 12 6 leading lead VBG work_arndyvdyobgtlpeh4rho7pywpi 12 7 to to IN work_arndyvdyobgtlpeh4rho7pywpi 12 8 early early JJ work_arndyvdyobgtlpeh4rho7pywpi 12 9 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 12 10 truncation truncation NN work_arndyvdyobgtlpeh4rho7pywpi 12 11 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 12 12 found find VBN work_arndyvdyobgtlpeh4rho7pywpi 12 13 in in IN work_arndyvdyobgtlpeh4rho7pywpi 12 14 two two CD work_arndyvdyobgtlpeh4rho7pywpi 12 15 nonclassified nonclassified JJ work_arndyvdyobgtlpeh4rho7pywpi 12 16 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 12 17 . . . work_arndyvdyobgtlpeh4rho7pywpi 13 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 13 2 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 13 3 model model NN work_arndyvdyobgtlpeh4rho7pywpi 13 4 carrying carry VBG work_arndyvdyobgtlpeh4rho7pywpi 13 5 an an DT work_arndyvdyobgtlpeh4rho7pywpi 13 6 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 13 7 null null NN work_arndyvdyobgtlpeh4rho7pywpi 13 8 allele allele NNP work_arndyvdyobgtlpeh4rho7pywpi 13 9 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 13 10 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 13 11 constructed construct VBN work_arndyvdyobgtlpeh4rho7pywpi 13 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 13 13 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 13 14 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 13 15 to to TO work_arndyvdyobgtlpeh4rho7pywpi 13 16 dem- dem- RB work_arndyvdyobgtlpeh4rho7pywpi 13 17 onstrate onstrate VB work_arndyvdyobgtlpeh4rho7pywpi 13 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 13 19 in in IN work_arndyvdyobgtlpeh4rho7pywpi 13 20 vivo vivo NNP work_arndyvdyobgtlpeh4rho7pywpi 13 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 13 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 13 23 involvement involvement NN work_arndyvdyobgtlpeh4rho7pywpi 13 24 of of IN work_arndyvdyobgtlpeh4rho7pywpi 13 25 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 13 26 in in IN work_arndyvdyobgtlpeh4rho7pywpi 13 27 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 13 28 catabolism catabolism NN work_arndyvdyobgtlpeh4rho7pywpi 13 29 . . . work_arndyvdyobgtlpeh4rho7pywpi 14 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 14 2 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 14 3 establish establish VBP work_arndyvdyobgtlpeh4rho7pywpi 14 4 that that IN work_arndyvdyobgtlpeh4rho7pywpi 14 5 3-methylcrotonylgly- 3-methylcrotonylgly- CD work_arndyvdyobgtlpeh4rho7pywpi 14 6 cinuria cinuria JJ work_arndyvdyobgtlpeh4rho7pywpi 14 7 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 14 8 from from IN work_arndyvdyobgtlpeh4rho7pywpi 14 9 loss loss NN work_arndyvdyobgtlpeh4rho7pywpi 14 10 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 14 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 14 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 14 13 function function NN work_arndyvdyobgtlpeh4rho7pywpi 14 14 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 14 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 14 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 14 17 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 14 18 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 14 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 14 20 a a NN work_arndyvdyobgtlpeh4rho7pywpi 14 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 14 22 b b NN work_arndyvdyobgtlpeh4rho7pywpi 14 23 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 14 24 of of IN work_arndyvdyobgtlpeh4rho7pywpi 14 25 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 14 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 14 27 complete complete VB work_arndyvdyobgtlpeh4rho7pywpi 14 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 14 29 genetic genetic JJ work_arndyvdyobgtlpeh4rho7pywpi 14 30 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 14 31 of of IN work_arndyvdyobgtlpeh4rho7pywpi 14 32 the the DT work_arndyvdyobgtlpeh4rho7pywpi 14 33 four four CD work_arndyvdyobgtlpeh4rho7pywpi 14 34 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 14 35 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 14 36 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 14 37 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 14 38 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 14 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 15 1 Introduction introduction NN work_arndyvdyobgtlpeh4rho7pywpi 15 2 3-Methylcrotonylglycinuria 3-methylcrotonylglycinuria CD work_arndyvdyobgtlpeh4rho7pywpi 15 3 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 15 4 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 15 5 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 15 6 MIM MIM NNP work_arndyvdyobgtlpeh4rho7pywpi 15 7 210200 210200 CD work_arndyvdyobgtlpeh4rho7pywpi 15 8 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 15 9 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 15 10 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 15 11 an an DT work_arndyvdyobgtlpeh4rho7pywpi 15 12 inborn inborn JJ work_arndyvdyobgtlpeh4rho7pywpi 15 13 error error NN work_arndyvdyobgtlpeh4rho7pywpi 15 14 of of IN work_arndyvdyobgtlpeh4rho7pywpi 15 15 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 15 16 catabolism catabolism NN work_arndyvdyobgtlpeh4rho7pywpi 15 17 and and CC work_arndyvdyobgtlpeh4rho7pywpi 15 18 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 15 19 from from IN work_arndyvdyobgtlpeh4rho7pywpi 15 20 isolated isolated JJ work_arndyvdyobgtlpeh4rho7pywpi 15 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 15 22 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 15 23 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 15 24 insensitive insensitive JJ work_arndyvdyobgtlpeh4rho7pywpi 15 25 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 15 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 15 27 3-methylcro- 3-methylcro- NNP work_arndyvdyobgtlpeh4rho7pywpi 15 28 tonyl tonyl NN work_arndyvdyobgtlpeh4rho7pywpi 15 29 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 15 30 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 15 31 carboxylase carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 15 32 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 15 33 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 15 34 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 15 35 E.C.6.4.1.4 E.C.6.4.1.4 NNP work_arndyvdyobgtlpeh4rho7pywpi 15 36 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 15 37 , , , work_arndyvdyobgtlpeh4rho7pywpi 15 38 the the DT work_arndyvdyobgtlpeh4rho7pywpi 15 39 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 15 40 converting convert VBG work_arndyvdyobgtlpeh4rho7pywpi 15 41 3-methylcrotonoyl 3-methylcrotonoyl CD work_arndyvdyobgtlpeh4rho7pywpi 15 42 - - : work_arndyvdyobgtlpeh4rho7pywpi 15 43 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 15 44 to to IN work_arndyvdyobgtlpeh4rho7pywpi 15 45 3-methylgluta- 3-methylgluta- CD work_arndyvdyobgtlpeh4rho7pywpi 15 46 conyl conyl NN work_arndyvdyobgtlpeh4rho7pywpi 15 47 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 15 48 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 15 49 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 15 50 Sweetman Sweetman NNP work_arndyvdyobgtlpeh4rho7pywpi 15 51 and and CC work_arndyvdyobgtlpeh4rho7pywpi 15 52 Williams Williams NNP work_arndyvdyobgtlpeh4rho7pywpi 15 53 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 15 54 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 15 55 . . . work_arndyvdyobgtlpeh4rho7pywpi 16 1 This this DT work_arndyvdyobgtlpeh4rho7pywpi 16 2 mito- mito- NN work_arndyvdyobgtlpeh4rho7pywpi 16 3 chondrial chondrial JJ work_arndyvdyobgtlpeh4rho7pywpi 16 4 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 16 5 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 16 6 one one CD work_arndyvdyobgtlpeh4rho7pywpi 16 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 16 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 16 9 four four CD work_arndyvdyobgtlpeh4rho7pywpi 16 10 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 16 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 16 12 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 16 13 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 16 14 known know VBN work_arndyvdyobgtlpeh4rho7pywpi 16 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 16 16 humans human NNS work_arndyvdyobgtlpeh4rho7pywpi 16 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 16 18 Wolf Wolf NNP work_arndyvdyobgtlpeh4rho7pywpi 16 19 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 16 20 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 16 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 16 22 together together RB work_arndyvdyobgtlpeh4rho7pywpi 16 23 with with IN work_arndyvdyobgtlpeh4rho7pywpi 16 24 acetyl acetyl NNP work_arndyvdyobgtlpeh4rho7pywpi 16 25 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 16 26 carboxylase carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 16 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 16 28 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 16 29 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 16 30 , , , work_arndyvdyobgtlpeh4rho7pywpi 16 31 pyruvate pyruvate VB work_arndyvdyobgtlpeh4rho7pywpi 16 32 carbox- carbox- NN work_arndyvdyobgtlpeh4rho7pywpi 16 33 ylase ylase NNP work_arndyvdyobgtlpeh4rho7pywpi 16 34 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 16 35 PC PC NNP work_arndyvdyobgtlpeh4rho7pywpi 16 36 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 16 37 , , , work_arndyvdyobgtlpeh4rho7pywpi 16 38 and and CC work_arndyvdyobgtlpeh4rho7pywpi 16 39 propionyl propionyl NNP work_arndyvdyobgtlpeh4rho7pywpi 16 40 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 16 41 carboxylase carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 16 42 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 16 43 PCC PCC NNP work_arndyvdyobgtlpeh4rho7pywpi 16 44 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 16 45 . . . work_arndyvdyobgtlpeh4rho7pywpi 17 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 17 2 marked marked JJ work_arndyvdyobgtlpeh4rho7pywpi 17 3 similarity similarity NN work_arndyvdyobgtlpeh4rho7pywpi 17 4 to to IN work_arndyvdyobgtlpeh4rho7pywpi 17 5 PCC PCC NNP work_arndyvdyobgtlpeh4rho7pywpi 17 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 17 7 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 17 8 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 17 9 a a DT work_arndyvdyobgtlpeh4rho7pywpi 17 10 hetero hetero NN work_arndyvdyobgtlpeh4rho7pywpi 17 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 17 12 oligomeric oligomeric NN work_arndyvdyobgtlpeh4rho7pywpi 17 13 Received Received NNP work_arndyvdyobgtlpeh4rho7pywpi 17 14 November November NNP work_arndyvdyobgtlpeh4rho7pywpi 17 15 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 17 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 17 17 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 17 18 ; ; , work_arndyvdyobgtlpeh4rho7pywpi 17 19 accepted accept VBN work_arndyvdyobgtlpeh4rho7pywpi 17 20 for for IN work_arndyvdyobgtlpeh4rho7pywpi 17 21 publication publication NN work_arndyvdyobgtlpeh4rho7pywpi 17 22 December December NNP work_arndyvdyobgtlpeh4rho7pywpi 17 23 12 12 CD work_arndyvdyobgtlpeh4rho7pywpi 17 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 17 25 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 17 26 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 17 27 electronically electronically RB work_arndyvdyobgtlpeh4rho7pywpi 17 28 published publish VBN work_arndyvdyobgtlpeh4rho7pywpi 17 29 January January NNP work_arndyvdyobgtlpeh4rho7pywpi 17 30 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 17 31 , , , work_arndyvdyobgtlpeh4rho7pywpi 17 32 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 17 33 . . . work_arndyvdyobgtlpeh4rho7pywpi 18 1 Address address NN work_arndyvdyobgtlpeh4rho7pywpi 18 2 for for IN work_arndyvdyobgtlpeh4rho7pywpi 18 3 correspondence correspondence NN work_arndyvdyobgtlpeh4rho7pywpi 18 4 and and CC work_arndyvdyobgtlpeh4rho7pywpi 18 5 reprints reprint NNS work_arndyvdyobgtlpeh4rho7pywpi 18 6 : : : work_arndyvdyobgtlpeh4rho7pywpi 18 7 Dr. Dr. NNP work_arndyvdyobgtlpeh4rho7pywpi 18 8 Magdalena Magdalena NNP work_arndyvdyobgtlpeh4rho7pywpi 18 9 Ugarte Ugarte NNP work_arndyvdyobgtlpeh4rho7pywpi 18 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 18 11 Centro Centro NNP work_arndyvdyobgtlpeh4rho7pywpi 18 12 de de IN work_arndyvdyobgtlpeh4rho7pywpi 18 13 Biologı́a Biologı́a NNP work_arndyvdyobgtlpeh4rho7pywpi 18 14 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 18 15 CSIC CSIC NNP work_arndyvdyobgtlpeh4rho7pywpi 18 16 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 18 17 UAM UAM NNP work_arndyvdyobgtlpeh4rho7pywpi 18 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 18 19 Universidad Universidad NNP work_arndyvdyobgtlpeh4rho7pywpi 18 20 Autónoma Autónoma NNP work_arndyvdyobgtlpeh4rho7pywpi 18 21 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 18 22 Madrid Madrid NNP work_arndyvdyobgtlpeh4rho7pywpi 18 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 18 24 28049 28049 CD work_arndyvdyobgtlpeh4rho7pywpi 18 25 Madrid Madrid NNP work_arndyvdyobgtlpeh4rho7pywpi 18 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 18 27 Spain Spain NNP work_arndyvdyobgtlpeh4rho7pywpi 18 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 19 1 E e NN work_arndyvdyobgtlpeh4rho7pywpi 19 2 - - NN work_arndyvdyobgtlpeh4rho7pywpi 19 3 mail mail NN work_arndyvdyobgtlpeh4rho7pywpi 19 4 : : : work_arndyvdyobgtlpeh4rho7pywpi 19 5 mugarte@cbm.uam.es mugarte@cbm.uam.es NNP work_arndyvdyobgtlpeh4rho7pywpi 19 6 ∗ ∗ NNP work_arndyvdyobgtlpeh4rho7pywpi 19 7 The the DT work_arndyvdyobgtlpeh4rho7pywpi 19 8 first first JJ work_arndyvdyobgtlpeh4rho7pywpi 19 9 three three CD work_arndyvdyobgtlpeh4rho7pywpi 19 10 authors author NNS work_arndyvdyobgtlpeh4rho7pywpi 19 11 contributed contribute VBD work_arndyvdyobgtlpeh4rho7pywpi 19 12 equally equally RB work_arndyvdyobgtlpeh4rho7pywpi 19 13 to to IN work_arndyvdyobgtlpeh4rho7pywpi 19 14 this this DT work_arndyvdyobgtlpeh4rho7pywpi 19 15 work work NN work_arndyvdyobgtlpeh4rho7pywpi 19 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 20 1 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 20 2 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 20 3 by by IN work_arndyvdyobgtlpeh4rho7pywpi 20 4 The the DT work_arndyvdyobgtlpeh4rho7pywpi 20 5 American American NNP work_arndyvdyobgtlpeh4rho7pywpi 20 6 Society Society NNP work_arndyvdyobgtlpeh4rho7pywpi 20 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 20 8 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 20 9 Genetics Genetics NNPS work_arndyvdyobgtlpeh4rho7pywpi 20 10 . . . work_arndyvdyobgtlpeh4rho7pywpi 21 1 All all DT work_arndyvdyobgtlpeh4rho7pywpi 21 2 rights right NNS work_arndyvdyobgtlpeh4rho7pywpi 21 3 reserved reserve VBD work_arndyvdyobgtlpeh4rho7pywpi 21 4 . . . work_arndyvdyobgtlpeh4rho7pywpi 22 1 0002 0002 CD work_arndyvdyobgtlpeh4rho7pywpi 22 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 22 3 9297/2001/6802 9297/2001/6802 CD work_arndyvdyobgtlpeh4rho7pywpi 22 4 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 22 5 0005$02.00 0005$02.00 CD work_arndyvdyobgtlpeh4rho7pywpi 22 6 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 22 7 consisting consist VBG work_arndyvdyobgtlpeh4rho7pywpi 22 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 22 9 a a DT work_arndyvdyobgtlpeh4rho7pywpi 22 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 22 11 b b NN work_arndyvdyobgtlpeh4rho7pywpi 22 12 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 22 13 . . . work_arndyvdyobgtlpeh4rho7pywpi 23 1 Both both DT work_arndyvdyobgtlpeh4rho7pywpi 23 2 PCCa PCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 23 3 and and CC work_arndyvdyobgtlpeh4rho7pywpi 23 4 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 23 5 contain contain VBP work_arndyvdyobgtlpeh4rho7pywpi 23 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 23 7 covalently covalently RB work_arndyvdyobgtlpeh4rho7pywpi 23 8 bound bind VBN work_arndyvdyobgtlpeh4rho7pywpi 23 9 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 23 10 moiety moiety NN work_arndyvdyobgtlpeh4rho7pywpi 23 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 23 12 as as RB work_arndyvdyobgtlpeh4rho7pywpi 23 13 well well RB work_arndyvdyobgtlpeh4rho7pywpi 23 14 as as IN work_arndyvdyobgtlpeh4rho7pywpi 23 15 binding bind VBG work_arndyvdyobgtlpeh4rho7pywpi 23 16 sites site NNS work_arndyvdyobgtlpeh4rho7pywpi 23 17 for for IN work_arndyvdyobgtlpeh4rho7pywpi 23 18 two two CD work_arndyvdyobgtlpeh4rho7pywpi 23 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 23 20 the the DT work_arndyvdyobgtlpeh4rho7pywpi 23 21 substrates substrate NNS work_arndyvdyobgtlpeh4rho7pywpi 23 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 23 23 HCO3 HCO3 NNP work_arndyvdyobgtlpeh4rho7pywpi 23 24 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 23 25 and and CC work_arndyvdyobgtlpeh4rho7pywpi 23 26 ATP ATP NNP work_arndyvdyobgtlpeh4rho7pywpi 23 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 23 28 whereas whereas IN work_arndyvdyobgtlpeh4rho7pywpi 23 29 the the DT work_arndyvdyobgtlpeh4rho7pywpi 23 30 b b NN work_arndyvdyobgtlpeh4rho7pywpi 23 31 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 23 32 contain contain VBP work_arndyvdyobgtlpeh4rho7pywpi 23 33 the the DT work_arndyvdyobgtlpeh4rho7pywpi 23 34 binding bind VBG work_arndyvdyobgtlpeh4rho7pywpi 23 35 site site NN work_arndyvdyobgtlpeh4rho7pywpi 23 36 for for IN work_arndyvdyobgtlpeh4rho7pywpi 23 37 the the DT work_arndyvdyobgtlpeh4rho7pywpi 23 38 acyl acyl NNP work_arndyvdyobgtlpeh4rho7pywpi 23 39 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 23 40 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 23 41 substrate substrate NN work_arndyvdyobgtlpeh4rho7pywpi 23 42 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 23 43 Lau Lau NNP work_arndyvdyobgtlpeh4rho7pywpi 23 44 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 23 45 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 23 46 . . . work_arndyvdyobgtlpeh4rho7pywpi 24 1 1980 1980 CD work_arndyvdyobgtlpeh4rho7pywpi 24 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 24 3 Lamhonwah Lamhonwah NNP work_arndyvdyobgtlpeh4rho7pywpi 24 4 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 24 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 24 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 25 1 1986 1986 CD work_arndyvdyobgtlpeh4rho7pywpi 25 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 25 3 Song Song NNP work_arndyvdyobgtlpeh4rho7pywpi 25 4 et et FW work_arndyvdyobgtlpeh4rho7pywpi 25 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 25 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 26 1 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 26 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 26 3 Sweetman Sweetman NNP work_arndyvdyobgtlpeh4rho7pywpi 26 4 and and CC work_arndyvdyobgtlpeh4rho7pywpi 26 5 Williams Williams NNP work_arndyvdyobgtlpeh4rho7pywpi 26 6 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 26 7 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 26 8 . . . work_arndyvdyobgtlpeh4rho7pywpi 27 1 Patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 27 2 with with IN work_arndyvdyobgtlpeh4rho7pywpi 27 3 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 27 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 27 5 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 27 6 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 27 7 inherited inherit VBN work_arndyvdyobgtlpeh4rho7pywpi 27 8 as as IN work_arndyvdyobgtlpeh4rho7pywpi 27 9 an an DT work_arndyvdyobgtlpeh4rho7pywpi 27 10 auto- auto- FW work_arndyvdyobgtlpeh4rho7pywpi 27 11 somal somal JJ work_arndyvdyobgtlpeh4rho7pywpi 27 12 recessive recessive JJ work_arndyvdyobgtlpeh4rho7pywpi 27 13 trait trait NN work_arndyvdyobgtlpeh4rho7pywpi 27 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 27 15 show show VB work_arndyvdyobgtlpeh4rho7pywpi 27 16 a a DT work_arndyvdyobgtlpeh4rho7pywpi 27 17 highly highly RB work_arndyvdyobgtlpeh4rho7pywpi 27 18 variable variable JJ work_arndyvdyobgtlpeh4rho7pywpi 27 19 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 27 20 phenotype phenotype NN work_arndyvdyobgtlpeh4rho7pywpi 27 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 27 22 ranging range VBG work_arndyvdyobgtlpeh4rho7pywpi 27 23 from from IN work_arndyvdyobgtlpeh4rho7pywpi 27 24 asymptomatic asymptomatic JJ work_arndyvdyobgtlpeh4rho7pywpi 27 25 to to IN work_arndyvdyobgtlpeh4rho7pywpi 27 26 severe severe JJ work_arndyvdyobgtlpeh4rho7pywpi 27 27 . . . work_arndyvdyobgtlpeh4rho7pywpi 28 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 28 2 the the DT work_arndyvdyobgtlpeh4rho7pywpi 28 3 latter latter JJ work_arndyvdyobgtlpeh4rho7pywpi 28 4 phenotype phenotype NN work_arndyvdyobgtlpeh4rho7pywpi 28 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 28 6 episodes episode NNS work_arndyvdyobgtlpeh4rho7pywpi 28 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 28 8 acute acute JJ work_arndyvdyobgtlpeh4rho7pywpi 28 9 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 28 10 decom- decom- JJ work_arndyvdyobgtlpeh4rho7pywpi 28 11 pensation pensation NN work_arndyvdyobgtlpeh4rho7pywpi 28 12 can can MD work_arndyvdyobgtlpeh4rho7pywpi 28 13 lead lead VB work_arndyvdyobgtlpeh4rho7pywpi 28 14 to to IN work_arndyvdyobgtlpeh4rho7pywpi 28 15 coma coma NN work_arndyvdyobgtlpeh4rho7pywpi 28 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 28 17 lethargy lethargy NN work_arndyvdyobgtlpeh4rho7pywpi 28 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 28 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 28 20 death death NN work_arndyvdyobgtlpeh4rho7pywpi 28 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 28 22 Sweet- Sweet- NNP work_arndyvdyobgtlpeh4rho7pywpi 28 23 man man NN work_arndyvdyobgtlpeh4rho7pywpi 28 24 and and CC work_arndyvdyobgtlpeh4rho7pywpi 28 25 Williams Williams NNP work_arndyvdyobgtlpeh4rho7pywpi 28 26 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 28 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 28 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 29 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 29 2 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 29 3 phenotype phenotype NN work_arndyvdyobgtlpeh4rho7pywpi 29 4 characterizing characterize VBG work_arndyvdyobgtlpeh4rho7pywpi 29 5 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 29 6 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 29 7 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 29 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 29 9 elevated elevated JJ work_arndyvdyobgtlpeh4rho7pywpi 29 10 excre- excre- NN work_arndyvdyobgtlpeh4rho7pywpi 29 11 tion tion NN work_arndyvdyobgtlpeh4rho7pywpi 29 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 29 13 the the DT work_arndyvdyobgtlpeh4rho7pywpi 29 14 diagnostic diagnostic JJ work_arndyvdyobgtlpeh4rho7pywpi 29 15 compounds compound NNS work_arndyvdyobgtlpeh4rho7pywpi 29 16 3-methylcrotonylgly- 3-methylcrotonylgly- NNPS work_arndyvdyobgtlpeh4rho7pywpi 29 17 cine cine NN work_arndyvdyobgtlpeh4rho7pywpi 29 18 or or CC work_arndyvdyobgtlpeh4rho7pywpi 29 19 3-hydroxyisovaleric 3-hydroxyisovaleric CD work_arndyvdyobgtlpeh4rho7pywpi 29 20 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 29 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 29 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 29 23 presence presence NN work_arndyvdyobgtlpeh4rho7pywpi 29 24 of of IN work_arndyvdyobgtlpeh4rho7pywpi 29 25 abnormally abnormally RB work_arndyvdyobgtlpeh4rho7pywpi 29 26 elevated elevate VBN work_arndyvdyobgtlpeh4rho7pywpi 29 27 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 29 28 or or CC work_arndyvdyobgtlpeh4rho7pywpi 29 29 urine urine NN work_arndyvdyobgtlpeh4rho7pywpi 29 30 levels level NNS work_arndyvdyobgtlpeh4rho7pywpi 29 31 of of IN work_arndyvdyobgtlpeh4rho7pywpi 29 32 3-hydrox- 3-hydrox- CD work_arndyvdyobgtlpeh4rho7pywpi 29 33 yisovalerylcarnitine yisovalerylcarnitine PRP$ work_arndyvdyobgtlpeh4rho7pywpi 29 34 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 29 35 C5-OH c5-oh NN work_arndyvdyobgtlpeh4rho7pywpi 29 36 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 29 37 , , , work_arndyvdyobgtlpeh4rho7pywpi 29 38 as as IN work_arndyvdyobgtlpeh4rho7pywpi 29 39 determined determine VBN work_arndyvdyobgtlpeh4rho7pywpi 29 40 by by IN work_arndyvdyobgtlpeh4rho7pywpi 29 41 tandem tandem NNP work_arndyvdyobgtlpeh4rho7pywpi 29 42 mass mass NNP work_arndyvdyobgtlpeh4rho7pywpi 29 43 spectrometry spectrometry NNP work_arndyvdyobgtlpeh4rho7pywpi 29 44 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 29 45 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 29 46 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 29 47 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 29 48 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 29 49 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 29 50 van van NNP work_arndyvdyobgtlpeh4rho7pywpi 29 51 Hove Hove NNP work_arndyvdyobgtlpeh4rho7pywpi 29 52 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 29 53 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 29 54 . . . work_arndyvdyobgtlpeh4rho7pywpi 30 1 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 30 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 30 3 Gib- Gib- NNP work_arndyvdyobgtlpeh4rho7pywpi 30 4 son son NN work_arndyvdyobgtlpeh4rho7pywpi 30 5 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 30 6 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 30 7 . . . work_arndyvdyobgtlpeh4rho7pywpi 31 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 31 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 31 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 32 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 32 2 recent recent JJ work_arndyvdyobgtlpeh4rho7pywpi 32 3 introduction introduction NN work_arndyvdyobgtlpeh4rho7pywpi 32 4 of of IN work_arndyvdyobgtlpeh4rho7pywpi 32 5 neonatal neonatal JJ work_arndyvdyobgtlpeh4rho7pywpi 32 6 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 32 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 32 8 organic organic JJ work_arndyvdyobgtlpeh4rho7pywpi 32 9 acidurias acidurias NNP work_arndyvdyobgtlpeh4rho7pywpi 32 10 by by IN work_arndyvdyobgtlpeh4rho7pywpi 32 11 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 32 12 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 32 13 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 32 14 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 32 15 revealed reveal VBN work_arndyvdyobgtlpeh4rho7pywpi 32 16 Gallardo Gallardo NNP work_arndyvdyobgtlpeh4rho7pywpi 32 17 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 32 18 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 32 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 33 1 : : : work_arndyvdyobgtlpeh4rho7pywpi 33 2 3-Methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 33 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 33 4 CoA coa NN work_arndyvdyobgtlpeh4rho7pywpi 33 5 Carboxylase Carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 33 6 Deficiency Deficiency NNP work_arndyvdyobgtlpeh4rho7pywpi 33 7 335 335 CD work_arndyvdyobgtlpeh4rho7pywpi 33 8 Table table NN work_arndyvdyobgtlpeh4rho7pywpi 33 9 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 33 10 Primers Primers NNPS work_arndyvdyobgtlpeh4rho7pywpi 33 11 for for IN work_arndyvdyobgtlpeh4rho7pywpi 33 12 Amplification Amplification NNP work_arndyvdyobgtlpeh4rho7pywpi 33 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 33 14 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 33 15 and and CC work_arndyvdyobgtlpeh4rho7pywpi 33 16 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 33 17 Sequences Sequences NNPS work_arndyvdyobgtlpeh4rho7pywpi 33 18 FORWARD FORWARD NNP work_arndyvdyobgtlpeh4rho7pywpi 33 19 PRIMER PRIMER NNP work_arndyvdyobgtlpeh4rho7pywpi 33 20 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 33 21 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 33 22 ′r3′ ′r3′ NNP work_arndyvdyobgtlpeh4rho7pywpi 33 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 33 24 REVERSE reverse NN work_arndyvdyobgtlpeh4rho7pywpi 33 25 PRIMER PRIMER NNP work_arndyvdyobgtlpeh4rho7pywpi 33 26 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 33 27 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 33 28 ′r3′ ′r3′ NNP work_arndyvdyobgtlpeh4rho7pywpi 33 29 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 33 30 AMPLIFIED AMPLIFIED NNP work_arndyvdyobgtlpeh4rho7pywpi 33 31 TARGET TARGET NNP work_arndyvdyobgtlpeh4rho7pywpi 33 32 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 33 33 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 33 34 FRAGMENT FRAGMENT NNP work_arndyvdyobgtlpeh4rho7pywpi 33 35 SIZE size NN work_arndyvdyobgtlpeh4rho7pywpi 33 36 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 33 37 bp bp NN work_arndyvdyobgtlpeh4rho7pywpi 33 38 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 33 39 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 33 40 TGGAATTTCTAGTAAGGCAAGCa TGGAATTTCTAGTAAGGCAAGCa NNP work_arndyvdyobgtlpeh4rho7pywpi 33 41 AAGTTGTGTTTCTCTTGCCTTCa AAGTTGTGTTTCTCTTGCCTTCa NNS work_arndyvdyobgtlpeh4rho7pywpi 33 42 Exon exon CC work_arndyvdyobgtlpeh4rho7pywpi 33 43 9 9 CD work_arndyvdyobgtlpeh4rho7pywpi 33 44 219 219 CD work_arndyvdyobgtlpeh4rho7pywpi 33 45 ACCATTGAATGAAGACAGCGGb ACCATTGAATGAAGACAGCGGb NNS work_arndyvdyobgtlpeh4rho7pywpi 33 46 GTGCTGGGACTACAGGCTTGb GTGCTGGGACTACAGGCTTGb NNS work_arndyvdyobgtlpeh4rho7pywpi 33 47 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 48 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 33 49 306 306 CD work_arndyvdyobgtlpeh4rho7pywpi 33 50 CATAAGAAACACTATTCTATTGCCb CATAAGAAACACTATTCTATTGCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 33 51 AATATGCTAGACAGTTCTGTAAGb AATATGCTAGACAGTTCTGTAAGb NNP work_arndyvdyobgtlpeh4rho7pywpi 33 52 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 53 11 11 CD work_arndyvdyobgtlpeh4rho7pywpi 33 54 316 316 CD work_arndyvdyobgtlpeh4rho7pywpi 33 55 AATCAGACAAAAGGGAATCGGa AATCAGACAAAAGGGAATCGGa NNS work_arndyvdyobgtlpeh4rho7pywpi 33 56 TAATTAGTGACCCAAATGCATGa TAATTAGTGACCCAAATGCATGa NNS work_arndyvdyobgtlpeh4rho7pywpi 33 57 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 58 19 19 CD work_arndyvdyobgtlpeh4rho7pywpi 33 59 194 194 CD work_arndyvdyobgtlpeh4rho7pywpi 33 60 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 33 61 GCTATATTTTGGATTAAGTATTATGc GCTATATTTTGGATTAAGTATTATGc NNP work_arndyvdyobgtlpeh4rho7pywpi 33 62 TACAAGACTGTCTAATAAAGTACc TACAAGACTGTCTAATAAAGTACc VBZ work_arndyvdyobgtlpeh4rho7pywpi 33 63 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 64 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 33 65 245 245 CD work_arndyvdyobgtlpeh4rho7pywpi 33 66 ATCTCTTAAATTCTCTCTCAATGc ATCTCTTAAATTCTCTCTCAATGc NNS work_arndyvdyobgtlpeh4rho7pywpi 33 67 CAAACTATTTGCATTTTACCAGCc CAAACTATTTGCATTTTACCAGCc NNP work_arndyvdyobgtlpeh4rho7pywpi 33 68 Exon Exon NNP work_arndyvdyobgtlpeh4rho7pywpi 33 69 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 33 70 226 226 CD work_arndyvdyobgtlpeh4rho7pywpi 33 71 GCTGTCATTGATACAAGTTTCCc GCTGTCATTGATACAAGTTTCCc NNS work_arndyvdyobgtlpeh4rho7pywpi 33 72 CATCCCAGAGTACCTAATTCGc catcccagagtacctaattcgc NN work_arndyvdyobgtlpeh4rho7pywpi 33 73 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 74 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 33 75 269 269 CD work_arndyvdyobgtlpeh4rho7pywpi 33 76 CTATAGAAGTCACTGCATGAGCTGc CTATAGAAGTCACTGCATGAGCTGc NNS work_arndyvdyobgtlpeh4rho7pywpi 33 77 TGTTCTGCATATTTAATTTCATCGc TGTTCTGCATATTTAATTTCATCGc NNS work_arndyvdyobgtlpeh4rho7pywpi 33 78 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 79 7 7 CD work_arndyvdyobgtlpeh4rho7pywpi 33 80 219 219 CD work_arndyvdyobgtlpeh4rho7pywpi 33 81 GAAAATTAACACATGTAGTAGCCa GAAAATTAACACATGTAGTAGCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 33 82 TATATTAATCATCTCAATAATACAGa tatattaatcatctcaataatacaga NN work_arndyvdyobgtlpeh4rho7pywpi 33 83 Exon exon NN work_arndyvdyobgtlpeh4rho7pywpi 33 84 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 33 85 300 300 CD work_arndyvdyobgtlpeh4rho7pywpi 33 86 AGGCAGCCAATGTGTTGGCd AGGCAGCCAATGTGTTGGCd NNP work_arndyvdyobgtlpeh4rho7pywpi 33 87 CTTTATTAGGAAAACATTTGATAGd CTTTATTAGGAAAACATTTGATAGd NNP work_arndyvdyobgtlpeh4rho7pywpi 33 88 3′ 3′ CD work_arndyvdyobgtlpeh4rho7pywpi 33 89 UTR UTR NNP work_arndyvdyobgtlpeh4rho7pywpi 33 90 2,100 2,100 CD work_arndyvdyobgtlpeh4rho7pywpi 33 91 a a DT work_arndyvdyobgtlpeh4rho7pywpi 33 92 Used use VBN work_arndyvdyobgtlpeh4rho7pywpi 33 93 only only RB work_arndyvdyobgtlpeh4rho7pywpi 33 94 in in IN work_arndyvdyobgtlpeh4rho7pywpi 33 95 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 33 96 mapping mapping NN work_arndyvdyobgtlpeh4rho7pywpi 33 97 . . . work_arndyvdyobgtlpeh4rho7pywpi 34 1 b b LS work_arndyvdyobgtlpeh4rho7pywpi 34 2 Used use VBD work_arndyvdyobgtlpeh4rho7pywpi 34 3 both both CC work_arndyvdyobgtlpeh4rho7pywpi 34 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 34 5 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 34 6 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 34 7 and/or and/or CC work_arndyvdyobgtlpeh4rho7pywpi 34 8 SSCP SSCP NNP work_arndyvdyobgtlpeh4rho7pywpi 34 9 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 34 10 with with IN work_arndyvdyobgtlpeh4rho7pywpi 34 11 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 34 12 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 34 13 DNA dna NN work_arndyvdyobgtlpeh4rho7pywpi 34 14 as as IN work_arndyvdyobgtlpeh4rho7pywpi 34 15 template template NN work_arndyvdyobgtlpeh4rho7pywpi 34 16 and and CC work_arndyvdyobgtlpeh4rho7pywpi 34 17 in in IN work_arndyvdyobgtlpeh4rho7pywpi 34 18 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 34 19 mapping mapping NN work_arndyvdyobgtlpeh4rho7pywpi 34 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 35 1 c c LS work_arndyvdyobgtlpeh4rho7pywpi 35 2 Used use VBD work_arndyvdyobgtlpeh4rho7pywpi 35 3 only only RB work_arndyvdyobgtlpeh4rho7pywpi 35 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 35 5 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 35 6 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 35 7 and/or and/or CC work_arndyvdyobgtlpeh4rho7pywpi 35 8 SSCP SSCP NNP work_arndyvdyobgtlpeh4rho7pywpi 35 9 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 35 10 with with IN work_arndyvdyobgtlpeh4rho7pywpi 35 11 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 35 12 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 35 13 DNA dna NN work_arndyvdyobgtlpeh4rho7pywpi 35 14 as as IN work_arndyvdyobgtlpeh4rho7pywpi 35 15 template template NN work_arndyvdyobgtlpeh4rho7pywpi 35 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 36 1 d d LS work_arndyvdyobgtlpeh4rho7pywpi 36 2 Used use VBN work_arndyvdyobgtlpeh4rho7pywpi 36 3 to to TO work_arndyvdyobgtlpeh4rho7pywpi 36 4 amplify amplify VB work_arndyvdyobgtlpeh4rho7pywpi 36 5 the the DT work_arndyvdyobgtlpeh4rho7pywpi 36 6 alternative alternative JJ work_arndyvdyobgtlpeh4rho7pywpi 36 7 long long JJ work_arndyvdyobgtlpeh4rho7pywpi 36 8 3′ 3′ CD work_arndyvdyobgtlpeh4rho7pywpi 36 9 UTR UTR NNP work_arndyvdyobgtlpeh4rho7pywpi 36 10 of of IN work_arndyvdyobgtlpeh4rho7pywpi 36 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 36 12 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 36 13 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 36 14 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 36 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 36 16 template template NN work_arndyvdyobgtlpeh4rho7pywpi 36 17 here here RB work_arndyvdyobgtlpeh4rho7pywpi 36 18 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 36 19 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 36 20 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 36 21 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 36 22 . . . work_arndyvdyobgtlpeh4rho7pywpi 37 1 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 37 2 as as IN work_arndyvdyobgtlpeh4rho7pywpi 37 3 an an DT work_arndyvdyobgtlpeh4rho7pywpi 37 4 unexpectedly unexpectedly RB work_arndyvdyobgtlpeh4rho7pywpi 37 5 frequent frequent JJ work_arndyvdyobgtlpeh4rho7pywpi 37 6 disorder disorder NN work_arndyvdyobgtlpeh4rho7pywpi 37 7 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 37 8 Naylor Naylor NNP work_arndyvdyobgtlpeh4rho7pywpi 37 9 and and CC work_arndyvdyobgtlpeh4rho7pywpi 37 10 Chace Chace NNP work_arndyvdyobgtlpeh4rho7pywpi 37 11 1999 1999 CD work_arndyvdyobgtlpeh4rho7pywpi 37 12 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 37 13 Ranieri Ranieri NNP work_arndyvdyobgtlpeh4rho7pywpi 37 14 et et FW work_arndyvdyobgtlpeh4rho7pywpi 37 15 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 37 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 38 1 2000a 2000a LS work_arndyvdyobgtlpeh4rho7pywpi 38 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 38 3 Roscher Roscher NNP work_arndyvdyobgtlpeh4rho7pywpi 38 4 et et FW work_arndyvdyobgtlpeh4rho7pywpi 38 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 38 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 39 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 39 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 39 3 Smith Smith NNP work_arndyvdyobgtlpeh4rho7pywpi 39 4 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 39 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 39 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 40 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 40 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 40 3 Wilcken Wilcken NNP work_arndyvdyobgtlpeh4rho7pywpi 40 4 et et FW work_arndyvdyobgtlpeh4rho7pywpi 40 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 40 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 41 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 41 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 41 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 42 1 Despite despite IN work_arndyvdyobgtlpeh4rho7pywpi 42 2 the the DT work_arndyvdyobgtlpeh4rho7pywpi 42 3 exponentially exponentially RB work_arndyvdyobgtlpeh4rho7pywpi 42 4 increasing increase VBG work_arndyvdyobgtlpeh4rho7pywpi 42 5 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 42 6 information information NN work_arndyvdyobgtlpeh4rho7pywpi 42 7 availa- availa- NNP work_arndyvdyobgtlpeh4rho7pywpi 42 8 ble ble NNP work_arndyvdyobgtlpeh4rho7pywpi 42 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 42 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 42 11 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 42 12 for for IN work_arndyvdyobgtlpeh4rho7pywpi 42 13 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 42 14 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 42 15 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 42 16 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 42 17 not not RB work_arndyvdyobgtlpeh4rho7pywpi 42 18 yet yet RB work_arndyvdyobgtlpeh4rho7pywpi 42 19 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 42 20 characterized characterize VBN work_arndyvdyobgtlpeh4rho7pywpi 42 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 42 22 precluding preclude VBG work_arndyvdyobgtlpeh4rho7pywpi 42 23 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 42 24 studies study NNS work_arndyvdyobgtlpeh4rho7pywpi 42 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 42 26 this this DT work_arndyvdyobgtlpeh4rho7pywpi 42 27 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 42 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 43 1 Here here RB work_arndyvdyobgtlpeh4rho7pywpi 43 2 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 43 3 report report VBP work_arndyvdyobgtlpeh4rho7pywpi 43 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 43 5 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 43 6 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 43 7 and and CC work_arndyvdyobgtlpeh4rho7pywpi 43 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 43 9 structure structure NN work_arndyvdyobgtlpeh4rho7pywpi 43 10 of of IN work_arndyvdyobgtlpeh4rho7pywpi 43 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 43 12 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 43 13 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 43 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 43 15 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 43 16 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 43 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 43 18 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 43 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 43 20 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 43 21 a a NN work_arndyvdyobgtlpeh4rho7pywpi 43 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 43 23 b b NN work_arndyvdyobgtlpeh4rho7pywpi 43 24 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 43 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 43 26 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 43 27 . . . work_arndyvdyobgtlpeh4rho7pywpi 44 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 44 2 also also RB work_arndyvdyobgtlpeh4rho7pywpi 44 3 report report VBP work_arndyvdyobgtlpeh4rho7pywpi 44 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 44 5 for for IN work_arndyvdyobgtlpeh4rho7pywpi 44 6 both both DT work_arndyvdyobgtlpeh4rho7pywpi 44 7 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 44 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 44 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 44 10 identification identification NN work_arndyvdyobgtlpeh4rho7pywpi 44 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 44 12 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 44 13 leading lead VBG work_arndyvdyobgtlpeh4rho7pywpi 44 14 to to IN work_arndyvdyobgtlpeh4rho7pywpi 44 15 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 44 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 45 1 Finally finally RB work_arndyvdyobgtlpeh4rho7pywpi 45 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 45 3 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 45 4 use use VBP work_arndyvdyobgtlpeh4rho7pywpi 45 5 a a DT work_arndyvdyobgtlpeh4rho7pywpi 45 6 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 45 7 model model NN work_arndyvdyobgtlpeh4rho7pywpi 45 8 for for IN work_arndyvdyobgtlpeh4rho7pywpi 45 9 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 45 10 car- car- NNS work_arndyvdyobgtlpeh4rho7pywpi 45 11 rying rye VBG work_arndyvdyobgtlpeh4rho7pywpi 45 12 an an DT work_arndyvdyobgtlpeh4rho7pywpi 45 13 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 45 14 null null NN work_arndyvdyobgtlpeh4rho7pywpi 45 15 allele allele NNP work_arndyvdyobgtlpeh4rho7pywpi 45 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 45 17 to to TO work_arndyvdyobgtlpeh4rho7pywpi 45 18 demonstrate demonstrate VB work_arndyvdyobgtlpeh4rho7pywpi 45 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 45 20 in in IN work_arndyvdyobgtlpeh4rho7pywpi 45 21 vivo vivo NNP work_arndyvdyobgtlpeh4rho7pywpi 45 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 45 23 the the DT work_arndyvdyobgtlpeh4rho7pywpi 45 24 specific specific JJ work_arndyvdyobgtlpeh4rho7pywpi 45 25 involvement involvement NN work_arndyvdyobgtlpeh4rho7pywpi 45 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 45 27 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 45 28 in in IN work_arndyvdyobgtlpeh4rho7pywpi 45 29 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 45 30 catabolism catabolism NN work_arndyvdyobgtlpeh4rho7pywpi 45 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 46 1 Patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 46 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 46 3 Material material NN work_arndyvdyobgtlpeh4rho7pywpi 46 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 46 5 and and CC work_arndyvdyobgtlpeh4rho7pywpi 46 6 Methods Methods NNP work_arndyvdyobgtlpeh4rho7pywpi 46 7 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 46 8 Seven seven CD work_arndyvdyobgtlpeh4rho7pywpi 46 9 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 46 10 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 46 11 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 46 12 included include VBN work_arndyvdyobgtlpeh4rho7pywpi 46 13 in in IN work_arndyvdyobgtlpeh4rho7pywpi 46 14 this this DT work_arndyvdyobgtlpeh4rho7pywpi 46 15 study study NN work_arndyvdyobgtlpeh4rho7pywpi 46 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 47 1 All all DT work_arndyvdyobgtlpeh4rho7pywpi 47 2 eight eight CD work_arndyvdyobgtlpeh4rho7pywpi 47 3 probands proband NNS work_arndyvdyobgtlpeh4rho7pywpi 47 4 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 47 5 an an DT work_arndyvdyobgtlpeh4rho7pywpi 47 6 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 47 7 activity activity NN work_arndyvdyobgtlpeh4rho7pywpi 47 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 47 9 ! ! . work_arndyvdyobgtlpeh4rho7pywpi 47 10 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 47 11 % % NN work_arndyvdyobgtlpeh4rho7pywpi 47 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 47 13 that that DT work_arndyvdyobgtlpeh4rho7pywpi 47 14 in in IN work_arndyvdyobgtlpeh4rho7pywpi 47 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 47 16 controls control NNS work_arndyvdyobgtlpeh4rho7pywpi 47 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 47 18 in in IN work_arndyvdyobgtlpeh4rho7pywpi 47 19 extracts extract NNS work_arndyvdyobgtlpeh4rho7pywpi 47 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 47 21 lymphoblasts lymphoblast NNS work_arndyvdyobgtlpeh4rho7pywpi 47 22 or or CC work_arndyvdyobgtlpeh4rho7pywpi 47 23 cul- cul- RB work_arndyvdyobgtlpeh4rho7pywpi 47 24 tured ture VBN work_arndyvdyobgtlpeh4rho7pywpi 47 25 skin skin NN work_arndyvdyobgtlpeh4rho7pywpi 47 26 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 47 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 47 28 and and CC work_arndyvdyobgtlpeh4rho7pywpi 47 29 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 47 30 elevated elevated JJ work_arndyvdyobgtlpeh4rho7pywpi 47 31 urinary urinary NN work_arndyvdyobgtlpeh4rho7pywpi 47 32 ex- ex- XX work_arndyvdyobgtlpeh4rho7pywpi 47 33 cretion cretion NN work_arndyvdyobgtlpeh4rho7pywpi 47 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 47 35 the the DT work_arndyvdyobgtlpeh4rho7pywpi 47 36 diagnostic diagnostic JJ work_arndyvdyobgtlpeh4rho7pywpi 47 37 compounds compound NNS work_arndyvdyobgtlpeh4rho7pywpi 47 38 3-methylcroton- 3-methylcroton- NNP work_arndyvdyobgtlpeh4rho7pywpi 47 39 ylglycine ylglycine NN work_arndyvdyobgtlpeh4rho7pywpi 47 40 or or CC work_arndyvdyobgtlpeh4rho7pywpi 47 41 3-hydroxyisovaleric 3-hydroxyisovaleric CD work_arndyvdyobgtlpeh4rho7pywpi 47 42 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 47 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 48 1 Probands proband NNS work_arndyvdyobgtlpeh4rho7pywpi 48 2 15468 15468 CD work_arndyvdyobgtlpeh4rho7pywpi 48 3 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 48 4 Spain Spain NNP work_arndyvdyobgtlpeh4rho7pywpi 48 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 48 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 7 15469 15469 CD work_arndyvdyobgtlpeh4rho7pywpi 48 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 48 9 Argentina Argentina NNP work_arndyvdyobgtlpeh4rho7pywpi 48 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 48 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 48 13 15765 15765 CD work_arndyvdyobgtlpeh4rho7pywpi 48 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 48 15 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 48 16 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 48 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 48 18 presented present VBD work_arndyvdyobgtlpeh4rho7pywpi 48 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 20 at at IN work_arndyvdyobgtlpeh4rho7pywpi 48 21 ! ! . work_arndyvdyobgtlpeh4rho7pywpi 48 22 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 48 23 mo mo NN work_arndyvdyobgtlpeh4rho7pywpi 48 24 of of IN work_arndyvdyobgtlpeh4rho7pywpi 48 25 age age NN work_arndyvdyobgtlpeh4rho7pywpi 48 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 27 with with IN work_arndyvdyobgtlpeh4rho7pywpi 48 28 a a DT work_arndyvdyobgtlpeh4rho7pywpi 48 29 severe severe JJ work_arndyvdyobgtlpeh4rho7pywpi 48 30 episode episode NN work_arndyvdyobgtlpeh4rho7pywpi 48 31 of of IN work_arndyvdyobgtlpeh4rho7pywpi 48 32 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 48 33 decompensation decompensation NN work_arndyvdyobgtlpeh4rho7pywpi 48 34 with with IN work_arndyvdyobgtlpeh4rho7pywpi 48 35 hypoglycemia hypoglycemia NN work_arndyvdyobgtlpeh4rho7pywpi 48 36 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 37 hyper- hyper- NNP work_arndyvdyobgtlpeh4rho7pywpi 48 38 ammonemia ammonemia NNP work_arndyvdyobgtlpeh4rho7pywpi 48 39 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 40 hypocarnitinemia hypocarnitinemia NN work_arndyvdyobgtlpeh4rho7pywpi 48 41 , , , work_arndyvdyobgtlpeh4rho7pywpi 48 42 and and CC work_arndyvdyobgtlpeh4rho7pywpi 48 43 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 48 44 acidosis acidosis NN work_arndyvdyobgtlpeh4rho7pywpi 48 45 . . . work_arndyvdyobgtlpeh4rho7pywpi 49 1 Proband Proband NNP work_arndyvdyobgtlpeh4rho7pywpi 49 2 15766 15766 CD work_arndyvdyobgtlpeh4rho7pywpi 49 3 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 49 4 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 49 5 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 49 6 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 49 7 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 49 8 diagnosed diagnose VBN work_arndyvdyobgtlpeh4rho7pywpi 49 9 at at IN work_arndyvdyobgtlpeh4rho7pywpi 49 10 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 49 11 years year NNS work_arndyvdyobgtlpeh4rho7pywpi 49 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 49 13 age age NN work_arndyvdyobgtlpeh4rho7pywpi 49 14 . . . work_arndyvdyobgtlpeh4rho7pywpi 50 1 Probands proband NNS work_arndyvdyobgtlpeh4rho7pywpi 50 2 15626 15626 CD work_arndyvdyobgtlpeh4rho7pywpi 50 3 and and CC work_arndyvdyobgtlpeh4rho7pywpi 50 4 15628 15628 CD work_arndyvdyobgtlpeh4rho7pywpi 50 5 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 50 6 two two CD work_arndyvdyobgtlpeh4rho7pywpi 50 7 clinically clinically RB work_arndyvdyobgtlpeh4rho7pywpi 50 8 asymptomatic asymptomatic JJ work_arndyvdyobgtlpeh4rho7pywpi 50 9 female female JJ work_arndyvdyobgtlpeh4rho7pywpi 50 10 adults adult NNS work_arndyvdyobgtlpeh4rho7pywpi 50 11 belonging belong VBG work_arndyvdyobgtlpeh4rho7pywpi 50 12 to to IN work_arndyvdyobgtlpeh4rho7pywpi 50 13 the the DT work_arndyvdyobgtlpeh4rho7pywpi 50 14 Amish/ amish/ CD work_arndyvdyobgtlpeh4rho7pywpi 50 15 Mennonite Mennonite NNP work_arndyvdyobgtlpeh4rho7pywpi 50 16 population population NN work_arndyvdyobgtlpeh4rho7pywpi 50 17 who who WP work_arndyvdyobgtlpeh4rho7pywpi 50 18 came come VBD work_arndyvdyobgtlpeh4rho7pywpi 50 19 to to IN work_arndyvdyobgtlpeh4rho7pywpi 50 20 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 50 21 attention attention NN work_arndyvdyobgtlpeh4rho7pywpi 50 22 after after IN work_arndyvdyobgtlpeh4rho7pywpi 50 23 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 50 24 children child NNS work_arndyvdyobgtlpeh4rho7pywpi 50 25 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 50 26 suspected suspect VBN work_arndyvdyobgtlpeh4rho7pywpi 50 27 to to TO work_arndyvdyobgtlpeh4rho7pywpi 50 28 be be VB work_arndyvdyobgtlpeh4rho7pywpi 50 29 obligate obligate NN work_arndyvdyobgtlpeh4rho7pywpi 50 30 carriers carrier NNS work_arndyvdyobgtlpeh4rho7pywpi 50 31 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 50 32 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 50 33 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 50 34 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 50 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 51 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 51 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 51 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 52 1 Expressed express VBN work_arndyvdyobgtlpeh4rho7pywpi 52 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 52 3 Sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 52 4 Tags tag NNS work_arndyvdyobgtlpeh4rho7pywpi 52 5 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 52 6 ESTs ESTs NNP work_arndyvdyobgtlpeh4rho7pywpi 52 7 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 52 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 52 9 DNA DNA NNP work_arndyvdyobgtlpeh4rho7pywpi 52 10 Sequencing Sequencing NNP work_arndyvdyobgtlpeh4rho7pywpi 52 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 52 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 52 13 Chromosomal Chromosomal NNP work_arndyvdyobgtlpeh4rho7pywpi 52 14 Localization Localization NNP work_arndyvdyobgtlpeh4rho7pywpi 52 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 52 16 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 52 17 and and CC work_arndyvdyobgtlpeh4rho7pywpi 52 18 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 52 19 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 52 20 IMAGE IMAGE NNP work_arndyvdyobgtlpeh4rho7pywpi 52 21 ESTs est NNS work_arndyvdyobgtlpeh4rho7pywpi 52 22 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 52 23 obtained obtain VBN work_arndyvdyobgtlpeh4rho7pywpi 52 24 from from IN work_arndyvdyobgtlpeh4rho7pywpi 52 25 Incyte Incyte NNP work_arndyvdyobgtlpeh4rho7pywpi 52 26 Ge- Ge- NNP work_arndyvdyobgtlpeh4rho7pywpi 52 27 nomics nomic NNS work_arndyvdyobgtlpeh4rho7pywpi 52 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 53 1 Aspergillus aspergillus NN work_arndyvdyobgtlpeh4rho7pywpi 53 2 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 53 3 ESTs est NNS work_arndyvdyobgtlpeh4rho7pywpi 53 4 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 53 5 obtained obtain VBN work_arndyvdyobgtlpeh4rho7pywpi 53 6 from from IN work_arndyvdyobgtlpeh4rho7pywpi 53 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 53 8 Fungal Fungal NNP work_arndyvdyobgtlpeh4rho7pywpi 53 9 Genetics Genetics NNP work_arndyvdyobgtlpeh4rho7pywpi 53 10 Stock Stock NNP work_arndyvdyobgtlpeh4rho7pywpi 53 11 Centre Centre NNP work_arndyvdyobgtlpeh4rho7pywpi 53 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 54 1 DNA DNA NNP work_arndyvdyobgtlpeh4rho7pywpi 54 2 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 54 3 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 54 4 performed perform VBN work_arndyvdyobgtlpeh4rho7pywpi 54 5 with with IN work_arndyvdyobgtlpeh4rho7pywpi 54 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 54 7 dye dye NN work_arndyvdyobgtlpeh4rho7pywpi 54 8 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 54 9 terminator terminator NN work_arndyvdyobgtlpeh4rho7pywpi 54 10 cycle cycle NN work_arndyvdyobgtlpeh4rho7pywpi 54 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 54 12 sequencing sequence VBG work_arndyvdyobgtlpeh4rho7pywpi 54 13 kit kit NN work_arndyvdyobgtlpeh4rho7pywpi 54 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 54 15 PE PE NNP work_arndyvdyobgtlpeh4rho7pywpi 54 16 Biosystems Biosystems NNPS work_arndyvdyobgtlpeh4rho7pywpi 54 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 54 18 and and CC work_arndyvdyobgtlpeh4rho7pywpi 54 19 an an DT work_arndyvdyobgtlpeh4rho7pywpi 54 20 ABI abi NN work_arndyvdyobgtlpeh4rho7pywpi 54 21 PRISM prism NN work_arndyvdyobgtlpeh4rho7pywpi 54 22 377 377 CD work_arndyvdyobgtlpeh4rho7pywpi 54 23 automatic automatic JJ work_arndyvdyobgtlpeh4rho7pywpi 54 24 se- se- NN work_arndyvdyobgtlpeh4rho7pywpi 54 25 quencer quencer NN work_arndyvdyobgtlpeh4rho7pywpi 54 26 . . . work_arndyvdyobgtlpeh4rho7pywpi 55 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 55 2 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 55 3 and and CC work_arndyvdyobgtlpeh4rho7pywpi 55 4 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 55 5 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 55 6 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 55 7 mapped map VBN work_arndyvdyobgtlpeh4rho7pywpi 55 8 by by IN work_arndyvdyobgtlpeh4rho7pywpi 55 9 radiation radiation NN work_arndyvdyobgtlpeh4rho7pywpi 55 10 hybrid hybrid JJ work_arndyvdyobgtlpeh4rho7pywpi 55 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 55 12 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 55 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 55 14 mapping mapping NN work_arndyvdyobgtlpeh4rho7pywpi 55 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 55 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 55 17 Stanford Stanford NNP work_arndyvdyobgtlpeh4rho7pywpi 55 18 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 55 19 Genome Genome NNP work_arndyvdyobgtlpeh4rho7pywpi 55 20 Center Center NNP work_arndyvdyobgtlpeh4rho7pywpi 55 21 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 55 22 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 55 23 and and CC work_arndyvdyobgtlpeh4rho7pywpi 55 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 55 25 Genebridge Genebridge NNP work_arndyvdyobgtlpeh4rho7pywpi 55 26 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 55 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 55 28 Ra- ra- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 55 29 diation diation NN work_arndyvdyobgtlpeh4rho7pywpi 55 30 Hybrid Hybrid NNP work_arndyvdyobgtlpeh4rho7pywpi 55 31 Mapping Mapping NNP work_arndyvdyobgtlpeh4rho7pywpi 55 32 database database NN work_arndyvdyobgtlpeh4rho7pywpi 55 33 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 55 34 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 55 35 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 55 36 Gyapay Gyapay NNP work_arndyvdyobgtlpeh4rho7pywpi 55 37 et et FW work_arndyvdyobgtlpeh4rho7pywpi 55 38 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 55 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 56 1 1996 1996 CD work_arndyvdyobgtlpeh4rho7pywpi 56 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 56 3 Stewart Stewart NNP work_arndyvdyobgtlpeh4rho7pywpi 56 4 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 56 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 56 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 57 1 1997 1997 CD work_arndyvdyobgtlpeh4rho7pywpi 57 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 57 3 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 57 4 Research Research NNP work_arndyvdyobgtlpeh4rho7pywpi 57 5 Genetics Genetics NNP work_arndyvdyobgtlpeh4rho7pywpi 57 6 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 57 7 . . . work_arndyvdyobgtlpeh4rho7pywpi 58 1 Primers primer NNS work_arndyvdyobgtlpeh4rho7pywpi 58 2 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 58 3 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 58 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 58 5 table table NN work_arndyvdyobgtlpeh4rho7pywpi 58 6 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 58 7 . . . work_arndyvdyobgtlpeh4rho7pywpi 59 1 FISH FISH NNS work_arndyvdyobgtlpeh4rho7pywpi 59 2 Mapping Mapping NNP work_arndyvdyobgtlpeh4rho7pywpi 59 3 Metaphase Metaphase NNP work_arndyvdyobgtlpeh4rho7pywpi 59 4 chromosomes chromosome VBZ work_arndyvdyobgtlpeh4rho7pywpi 59 5 from from IN work_arndyvdyobgtlpeh4rho7pywpi 59 6 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 59 7 peripheral peripheral JJ work_arndyvdyobgtlpeh4rho7pywpi 59 8 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 59 9 lymphocytes lymphocyte NNS work_arndyvdyobgtlpeh4rho7pywpi 59 10 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 59 11 prepared prepare VBN work_arndyvdyobgtlpeh4rho7pywpi 59 12 as as IN work_arndyvdyobgtlpeh4rho7pywpi 59 13 described describe VBN work_arndyvdyobgtlpeh4rho7pywpi 59 14 elsewhere elsewhere RB work_arndyvdyobgtlpeh4rho7pywpi 59 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 59 16 Moorhead Moorhead NNP work_arndyvdyobgtlpeh4rho7pywpi 59 17 et et FW work_arndyvdyobgtlpeh4rho7pywpi 59 18 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 59 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 60 1 1960 1960 CD work_arndyvdyobgtlpeh4rho7pywpi 60 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 60 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 61 1 Slides slide NNS work_arndyvdyobgtlpeh4rho7pywpi 61 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 61 3 treated treat VBN work_arndyvdyobgtlpeh4rho7pywpi 61 4 with with IN work_arndyvdyobgtlpeh4rho7pywpi 61 5 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 61 6 # # $ work_arndyvdyobgtlpeh4rho7pywpi 61 7 SSC SSC NNP work_arndyvdyobgtlpeh4rho7pywpi 61 8 at at IN work_arndyvdyobgtlpeh4rho7pywpi 61 9 37 37 CD work_arndyvdyobgtlpeh4rho7pywpi 61 10 � � NNS work_arndyvdyobgtlpeh4rho7pywpi 61 11 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 61 12 for for IN work_arndyvdyobgtlpeh4rho7pywpi 61 13 30 30 CD work_arndyvdyobgtlpeh4rho7pywpi 61 14 min min NN work_arndyvdyobgtlpeh4rho7pywpi 61 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 61 16 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 61 17 dehydrated dehydrate VBN work_arndyvdyobgtlpeh4rho7pywpi 61 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 61 19 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 61 20 dena- dena- RB work_arndyvdyobgtlpeh4rho7pywpi 61 21 tured ture VBN work_arndyvdyobgtlpeh4rho7pywpi 61 22 for for IN work_arndyvdyobgtlpeh4rho7pywpi 61 23 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 61 24 min min NN work_arndyvdyobgtlpeh4rho7pywpi 61 25 at at IN work_arndyvdyobgtlpeh4rho7pywpi 61 26 70 70 CD work_arndyvdyobgtlpeh4rho7pywpi 61 27 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 61 28 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 61 29 in in IN work_arndyvdyobgtlpeh4rho7pywpi 61 30 70 70 CD work_arndyvdyobgtlpeh4rho7pywpi 61 31 % % NN work_arndyvdyobgtlpeh4rho7pywpi 61 32 formamide formamide NN work_arndyvdyobgtlpeh4rho7pywpi 61 33 , , , work_arndyvdyobgtlpeh4rho7pywpi 61 34 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 61 35 # # NNP work_arndyvdyobgtlpeh4rho7pywpi 61 36 SSC SSC NNP work_arndyvdyobgtlpeh4rho7pywpi 61 37 pH pH NNP work_arndyvdyobgtlpeh4rho7pywpi 61 38 7 7 CD work_arndyvdyobgtlpeh4rho7pywpi 61 39 , , , work_arndyvdyobgtlpeh4rho7pywpi 61 40 and and CC work_arndyvdyobgtlpeh4rho7pywpi 61 41 then then RB work_arndyvdyobgtlpeh4rho7pywpi 61 42 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 61 43 dehydrated dehydrate VBN work_arndyvdyobgtlpeh4rho7pywpi 61 44 again again RB work_arndyvdyobgtlpeh4rho7pywpi 61 45 . . . work_arndyvdyobgtlpeh4rho7pywpi 62 1 One one CD work_arndyvdyobgtlpeh4rho7pywpi 62 2 microgram microgram NN work_arndyvdyobgtlpeh4rho7pywpi 62 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 62 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 62 5 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 62 6 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 62 7 plasmid plasmid NN work_arndyvdyobgtlpeh4rho7pywpi 62 8 artificial artificial JJ work_arndyvdyobgtlpeh4rho7pywpi 62 9 chromosome chromosome NN work_arndyvdyobgtlpeh4rho7pywpi 62 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 62 11 PAC PAC NNP work_arndyvdyobgtlpeh4rho7pywpi 62 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 62 13 RPCIP-4 RPCIP-4 NNP work_arndyvdyobgtlpeh4rho7pywpi 62 14 615H13 615h13 CD work_arndyvdyobgtlpeh4rho7pywpi 62 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 62 16 Resource Resource NNP work_arndyvdyobgtlpeh4rho7pywpi 62 17 Center Center NNP work_arndyvdyobgtlpeh4rho7pywpi 62 18 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 62 19 Primary Primary NNP work_arndyvdyobgtlpeh4rho7pywpi 62 20 Da- Da- NNP work_arndyvdyobgtlpeh4rho7pywpi 62 21 tabase tabase JJ work_arndyvdyobgtlpeh4rho7pywpi 62 22 RZPD RZPD NNP work_arndyvdyobgtlpeh4rho7pywpi 62 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 62 24 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 62 25 labeled label VBN work_arndyvdyobgtlpeh4rho7pywpi 62 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 62 27 by by IN work_arndyvdyobgtlpeh4rho7pywpi 62 28 nick nick NN work_arndyvdyobgtlpeh4rho7pywpi 62 29 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 62 30 translation translation NN work_arndyvdyobgtlpeh4rho7pywpi 62 31 , , , work_arndyvdyobgtlpeh4rho7pywpi 62 32 with with IN work_arndyvdyobgtlpeh4rho7pywpi 62 33 SpectrumGreen SpectrumGreen NNP work_arndyvdyobgtlpeh4rho7pywpi 62 34 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 62 35 dUTP dutp NN work_arndyvdyobgtlpeh4rho7pywpi 62 36 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 62 37 Vysis vysis NN work_arndyvdyobgtlpeh4rho7pywpi 62 38 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 62 39 and and CC work_arndyvdyobgtlpeh4rho7pywpi 62 40 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 62 41 coprecipitated coprecipitate VBN work_arndyvdyobgtlpeh4rho7pywpi 62 42 with with IN work_arndyvdyobgtlpeh4rho7pywpi 62 43 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 62 44 mg mg CD work_arndyvdyobgtlpeh4rho7pywpi 62 45 of of IN work_arndyvdyobgtlpeh4rho7pywpi 62 46 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 62 47 Cot-1 Cot-1 NNP work_arndyvdyobgtlpeh4rho7pywpi 62 48 DNA DNA NNP work_arndyvdyobgtlpeh4rho7pywpi 62 49 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 62 50 Vysis Vysis NNP work_arndyvdyobgtlpeh4rho7pywpi 62 51 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 62 52 . . . work_arndyvdyobgtlpeh4rho7pywpi 63 1 DNA DNA NNP work_arndyvdyobgtlpeh4rho7pywpi 63 2 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 63 3 resuspended resuspend VBN work_arndyvdyobgtlpeh4rho7pywpi 63 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 63 5 50 50 CD work_arndyvdyobgtlpeh4rho7pywpi 63 6 % % NN work_arndyvdyobgtlpeh4rho7pywpi 63 7 formamide formamide NN work_arndyvdyobgtlpeh4rho7pywpi 63 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 63 9 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 63 10 # # NN work_arndyvdyobgtlpeh4rho7pywpi 63 11 SSC SSC NNP work_arndyvdyobgtlpeh4rho7pywpi 63 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 63 13 15 15 CD work_arndyvdyobgtlpeh4rho7pywpi 63 14 % % NN work_arndyvdyobgtlpeh4rho7pywpi 63 15 dextran dextran NN work_arndyvdyobgtlpeh4rho7pywpi 63 16 sulfate sulfate NN work_arndyvdyobgtlpeh4rho7pywpi 63 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 63 18 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 63 19 heat heat NN work_arndyvdyobgtlpeh4rho7pywpi 63 20 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 63 21 denatured denature VBN work_arndyvdyobgtlpeh4rho7pywpi 63 22 for for IN work_arndyvdyobgtlpeh4rho7pywpi 63 23 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 63 24 min min NN work_arndyvdyobgtlpeh4rho7pywpi 63 25 at at IN work_arndyvdyobgtlpeh4rho7pywpi 63 26 70 70 CD work_arndyvdyobgtlpeh4rho7pywpi 63 27 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 63 28 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 63 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 63 30 and and CC work_arndyvdyobgtlpeh4rho7pywpi 63 31 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 63 32 hybridized hybridize VBN work_arndyvdyobgtlpeh4rho7pywpi 63 33 to to IN work_arndyvdyobgtlpeh4rho7pywpi 63 34 slides slide NNS work_arndyvdyobgtlpeh4rho7pywpi 63 35 for for IN work_arndyvdyobgtlpeh4rho7pywpi 63 36 24 24 CD work_arndyvdyobgtlpeh4rho7pywpi 63 37 h h NN work_arndyvdyobgtlpeh4rho7pywpi 63 38 at at IN work_arndyvdyobgtlpeh4rho7pywpi 63 39 37 37 CD work_arndyvdyobgtlpeh4rho7pywpi 63 40 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 63 41 C. C. NNP work_arndyvdyobgtlpeh4rho7pywpi 64 1 Slides slide NNS work_arndyvdyobgtlpeh4rho7pywpi 64 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 64 3 336 336 CD work_arndyvdyobgtlpeh4rho7pywpi 64 4 Am am NN work_arndyvdyobgtlpeh4rho7pywpi 64 5 . . . work_arndyvdyobgtlpeh4rho7pywpi 65 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 65 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 65 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 66 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 66 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 67 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 67 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 67 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 67 4 washed wash VBD work_arndyvdyobgtlpeh4rho7pywpi 67 5 for for IN work_arndyvdyobgtlpeh4rho7pywpi 67 6 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 67 7 min min NN work_arndyvdyobgtlpeh4rho7pywpi 67 8 in in IN work_arndyvdyobgtlpeh4rho7pywpi 67 9 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 67 10 # # $ work_arndyvdyobgtlpeh4rho7pywpi 67 11 SSC SSC NNP work_arndyvdyobgtlpeh4rho7pywpi 67 12 at at IN work_arndyvdyobgtlpeh4rho7pywpi 67 13 60 60 CD work_arndyvdyobgtlpeh4rho7pywpi 67 14 � � NNS work_arndyvdyobgtlpeh4rho7pywpi 67 15 C. C. NNP work_arndyvdyobgtlpeh4rho7pywpi 68 1 Chromosomes chromosome NNS work_arndyvdyobgtlpeh4rho7pywpi 68 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 68 3 counterstained counterstaine VBN work_arndyvdyobgtlpeh4rho7pywpi 68 4 with with IN work_arndyvdyobgtlpeh4rho7pywpi 68 5 125 125 CD work_arndyvdyobgtlpeh4rho7pywpi 68 6 ng ng NNS work_arndyvdyobgtlpeh4rho7pywpi 68 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 68 8 DAPI dapi NN work_arndyvdyobgtlpeh4rho7pywpi 68 9 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 68 10 ml ml NN work_arndyvdyobgtlpeh4rho7pywpi 68 11 . . . work_arndyvdyobgtlpeh4rho7pywpi 69 1 Images image NNS work_arndyvdyobgtlpeh4rho7pywpi 69 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 69 3 visualized visualize VBN work_arndyvdyobgtlpeh4rho7pywpi 69 4 by by IN work_arndyvdyobgtlpeh4rho7pywpi 69 5 use use NN work_arndyvdyobgtlpeh4rho7pywpi 69 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 69 7 a a DT work_arndyvdyobgtlpeh4rho7pywpi 69 8 Nikon Nikon NNP work_arndyvdyobgtlpeh4rho7pywpi 69 9 Eclipse Eclipse NNP work_arndyvdyobgtlpeh4rho7pywpi 69 10 E400 E400 NNP work_arndyvdyobgtlpeh4rho7pywpi 69 11 fluo- fluo- NNP work_arndyvdyobgtlpeh4rho7pywpi 69 12 rescence rescence NN work_arndyvdyobgtlpeh4rho7pywpi 69 13 microscope microscope NN work_arndyvdyobgtlpeh4rho7pywpi 69 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 69 15 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 69 16 analyzed analyze VBN work_arndyvdyobgtlpeh4rho7pywpi 69 17 by by IN work_arndyvdyobgtlpeh4rho7pywpi 69 18 Smart- Smart- NNP work_arndyvdyobgtlpeh4rho7pywpi 69 19 Capture Capture NNP work_arndyvdyobgtlpeh4rho7pywpi 69 20 software software NN work_arndyvdyobgtlpeh4rho7pywpi 69 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 69 22 Vysis Vysis NNP work_arndyvdyobgtlpeh4rho7pywpi 69 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 69 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 70 1 Cell Cell NNP work_arndyvdyobgtlpeh4rho7pywpi 70 2 Culture Culture NNP work_arndyvdyobgtlpeh4rho7pywpi 70 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 70 4 Complementation Complementation NNP work_arndyvdyobgtlpeh4rho7pywpi 70 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 70 6 and and CC work_arndyvdyobgtlpeh4rho7pywpi 70 7 Biotin Biotin NNP work_arndyvdyobgtlpeh4rho7pywpi 70 8 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 70 9 Labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 70 10 Assays Assays NNPS work_arndyvdyobgtlpeh4rho7pywpi 70 11 Fibroblast Fibroblast NNP work_arndyvdyobgtlpeh4rho7pywpi 70 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 70 13 lymphoblast lymphoblast JJ work_arndyvdyobgtlpeh4rho7pywpi 70 14 cell cell NN work_arndyvdyobgtlpeh4rho7pywpi 70 15 lines line NNS work_arndyvdyobgtlpeh4rho7pywpi 70 16 obtained obtain VBN work_arndyvdyobgtlpeh4rho7pywpi 70 17 from from IN work_arndyvdyobgtlpeh4rho7pywpi 70 18 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 70 19 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 70 20 confirmed confirm VBN work_arndyvdyobgtlpeh4rho7pywpi 70 21 to to TO work_arndyvdyobgtlpeh4rho7pywpi 70 22 be be VB work_arndyvdyobgtlpeh4rho7pywpi 70 23 deficient deficient JJ work_arndyvdyobgtlpeh4rho7pywpi 70 24 in in IN work_arndyvdyobgtlpeh4rho7pywpi 70 25 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 70 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 70 27 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 70 28 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 70 29 assayed assay VBN work_arndyvdyobgtlpeh4rho7pywpi 70 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 70 31 extracts extract NNS work_arndyvdyobgtlpeh4rho7pywpi 70 32 by by IN work_arndyvdyobgtlpeh4rho7pywpi 70 33 measurement measurement NN work_arndyvdyobgtlpeh4rho7pywpi 70 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 70 35 the the DT work_arndyvdyobgtlpeh4rho7pywpi 70 36 incorpo- incorpo- NN work_arndyvdyobgtlpeh4rho7pywpi 70 37 ration ration NN work_arndyvdyobgtlpeh4rho7pywpi 70 38 of of IN work_arndyvdyobgtlpeh4rho7pywpi 70 39 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 70 40 14C]-HCO3 14c]-hco3 CD work_arndyvdyobgtlpeh4rho7pywpi 70 41 � � NNS work_arndyvdyobgtlpeh4rho7pywpi 70 42 into into IN work_arndyvdyobgtlpeh4rho7pywpi 70 43 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 70 44 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 70 45 precipitable precipitable JJ work_arndyvdyobgtlpeh4rho7pywpi 70 46 material material NN work_arndyvdyobgtlpeh4rho7pywpi 70 47 , , , work_arndyvdyobgtlpeh4rho7pywpi 70 48 as as IN work_arndyvdyobgtlpeh4rho7pywpi 70 49 described describe VBN work_arndyvdyobgtlpeh4rho7pywpi 70 50 elsewhere elsewhere RB work_arndyvdyobgtlpeh4rho7pywpi 70 51 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 70 52 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 70 53 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 70 54 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 70 55 . . . work_arndyvdyobgtlpeh4rho7pywpi 71 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 71 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 71 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 72 1 Cells cell NNS work_arndyvdyobgtlpeh4rho7pywpi 72 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 72 3 cul- cul- RB work_arndyvdyobgtlpeh4rho7pywpi 72 4 tured ture VBN work_arndyvdyobgtlpeh4rho7pywpi 72 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 72 6 according accord VBG work_arndyvdyobgtlpeh4rho7pywpi 72 7 to to IN work_arndyvdyobgtlpeh4rho7pywpi 72 8 standard standard JJ work_arndyvdyobgtlpeh4rho7pywpi 72 9 procedures procedure NNS work_arndyvdyobgtlpeh4rho7pywpi 72 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 72 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 72 12 minimal minimal JJ work_arndyvdyobgtlpeh4rho7pywpi 72 13 es- es- NN work_arndyvdyobgtlpeh4rho7pywpi 72 14 sential sential JJ work_arndyvdyobgtlpeh4rho7pywpi 72 15 medium medium NN work_arndyvdyobgtlpeh4rho7pywpi 72 16 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 72 17 MEM MEM NNP work_arndyvdyobgtlpeh4rho7pywpi 72 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 72 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 72 20 Life Life NNP work_arndyvdyobgtlpeh4rho7pywpi 72 21 Technologies Technologies NNP work_arndyvdyobgtlpeh4rho7pywpi 72 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 72 23 supplement- supplement- VBP work_arndyvdyobgtlpeh4rho7pywpi 72 24 ed ed NN work_arndyvdyobgtlpeh4rho7pywpi 72 25 with with IN work_arndyvdyobgtlpeh4rho7pywpi 72 26 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 72 27 % % NN work_arndyvdyobgtlpeh4rho7pywpi 72 28 glutamine glutamine NN work_arndyvdyobgtlpeh4rho7pywpi 72 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 72 30 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 72 31 % % NN work_arndyvdyobgtlpeh4rho7pywpi 72 32 fetal fetal JJ work_arndyvdyobgtlpeh4rho7pywpi 72 33 calf calf NN work_arndyvdyobgtlpeh4rho7pywpi 72 34 serum serum NN work_arndyvdyobgtlpeh4rho7pywpi 72 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 72 36 and and CC work_arndyvdyobgtlpeh4rho7pywpi 72 37 an- an- CC work_arndyvdyobgtlpeh4rho7pywpi 72 38 tibiotics tibiotic NNS work_arndyvdyobgtlpeh4rho7pywpi 72 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 73 1 For for IN work_arndyvdyobgtlpeh4rho7pywpi 73 2 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 73 3 experiments experiment NNS work_arndyvdyobgtlpeh4rho7pywpi 73 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 73 5 cells cell NNS work_arndyvdyobgtlpeh4rho7pywpi 73 6 from from IN work_arndyvdyobgtlpeh4rho7pywpi 73 7 two two CD work_arndyvdyobgtlpeh4rho7pywpi 73 8 different different JJ work_arndyvdyobgtlpeh4rho7pywpi 73 9 lines line NNS work_arndyvdyobgtlpeh4rho7pywpi 73 10 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 73 11 plated plate VBN work_arndyvdyobgtlpeh4rho7pywpi 73 12 together together RB work_arndyvdyobgtlpeh4rho7pywpi 73 13 at at IN work_arndyvdyobgtlpeh4rho7pywpi 73 14 an an DT work_arndyvdyobgtlpeh4rho7pywpi 73 15 equal equal JJ work_arndyvdyobgtlpeh4rho7pywpi 73 16 den- den- NN work_arndyvdyobgtlpeh4rho7pywpi 73 17 sity sity NN work_arndyvdyobgtlpeh4rho7pywpi 73 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 73 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 73 20 cell cell NN work_arndyvdyobgtlpeh4rho7pywpi 73 21 fusion fusion NN work_arndyvdyobgtlpeh4rho7pywpi 73 22 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 73 23 induced induce VBN work_arndyvdyobgtlpeh4rho7pywpi 73 24 in in IN work_arndyvdyobgtlpeh4rho7pywpi 73 25 MEM MEM NNP work_arndyvdyobgtlpeh4rho7pywpi 73 26 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 73 27 without without IN work_arndyvdyobgtlpeh4rho7pywpi 73 28 serum serum NN work_arndyvdyobgtlpeh4rho7pywpi 73 29 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 73 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 73 31 the the DT work_arndyvdyobgtlpeh4rho7pywpi 73 32 presence presence NN work_arndyvdyobgtlpeh4rho7pywpi 73 33 of of IN work_arndyvdyobgtlpeh4rho7pywpi 73 34 50 50 CD work_arndyvdyobgtlpeh4rho7pywpi 73 35 % % NN work_arndyvdyobgtlpeh4rho7pywpi 73 36 PEG PEG NNP work_arndyvdyobgtlpeh4rho7pywpi 73 37 4000 4000 CD work_arndyvdyobgtlpeh4rho7pywpi 73 38 for for IN work_arndyvdyobgtlpeh4rho7pywpi 73 39 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 73 40 min min NN work_arndyvdyobgtlpeh4rho7pywpi 73 41 . . . work_arndyvdyobgtlpeh4rho7pywpi 74 1 Cells cell NNS work_arndyvdyobgtlpeh4rho7pywpi 74 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 74 3 washed wash VBN work_arndyvdyobgtlpeh4rho7pywpi 74 4 to to TO work_arndyvdyobgtlpeh4rho7pywpi 74 5 remove remove VB work_arndyvdyobgtlpeh4rho7pywpi 74 6 residual residual JJ work_arndyvdyobgtlpeh4rho7pywpi 74 7 polyethylene polyethylene NN work_arndyvdyobgtlpeh4rho7pywpi 74 8 glycol glycol NNP work_arndyvdyobgtlpeh4rho7pywpi 74 9 4000 4000 CD work_arndyvdyobgtlpeh4rho7pywpi 74 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 74 11 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 74 12 cultured culture VBN work_arndyvdyobgtlpeh4rho7pywpi 74 13 for for IN work_arndyvdyobgtlpeh4rho7pywpi 74 14 a a DT work_arndyvdyobgtlpeh4rho7pywpi 74 15 further further JJ work_arndyvdyobgtlpeh4rho7pywpi 74 16 24 24 CD work_arndyvdyobgtlpeh4rho7pywpi 74 17 h h NN work_arndyvdyobgtlpeh4rho7pywpi 74 18 under under IN work_arndyvdyobgtlpeh4rho7pywpi 74 19 standard standard JJ work_arndyvdyobgtlpeh4rho7pywpi 74 20 condi- condi- NNP work_arndyvdyobgtlpeh4rho7pywpi 74 21 tions tion NNS work_arndyvdyobgtlpeh4rho7pywpi 74 22 . . . work_arndyvdyobgtlpeh4rho7pywpi 75 1 Then then RB work_arndyvdyobgtlpeh4rho7pywpi 75 2 the the DT work_arndyvdyobgtlpeh4rho7pywpi 75 3 cells cell NNS work_arndyvdyobgtlpeh4rho7pywpi 75 4 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 75 5 incubated incubate VBN work_arndyvdyobgtlpeh4rho7pywpi 75 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 75 7 MEM MEM NNP work_arndyvdyobgtlpeh4rho7pywpi 75 8 with with IN work_arndyvdyobgtlpeh4rho7pywpi 75 9 15 15 CD work_arndyvdyobgtlpeh4rho7pywpi 75 10 % % NN work_arndyvdyobgtlpeh4rho7pywpi 75 11 fetal fetal JJ work_arndyvdyobgtlpeh4rho7pywpi 75 12 calf calf NN work_arndyvdyobgtlpeh4rho7pywpi 75 13 serum serum NN work_arndyvdyobgtlpeh4rho7pywpi 75 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 75 15 0.1 0.1 CD work_arndyvdyobgtlpeh4rho7pywpi 75 16 mM mm NN work_arndyvdyobgtlpeh4rho7pywpi 75 17 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 75 18 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 75 19 - - SYM work_arndyvdyobgtlpeh4rho7pywpi 75 20 14C]-isovalerate 14c]-isovalerate CD work_arndyvdyobgtlpeh4rho7pywpi 75 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 75 22 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 75 23 mCi/ mCi/ NNP work_arndyvdyobgtlpeh4rho7pywpi 75 24 mmol mmol NN work_arndyvdyobgtlpeh4rho7pywpi 75 25 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 75 26 American American NNP work_arndyvdyobgtlpeh4rho7pywpi 75 27 Radiolabeled Radiolabeled NNP work_arndyvdyobgtlpeh4rho7pywpi 75 28 Chemicals Chemicals NNPS work_arndyvdyobgtlpeh4rho7pywpi 75 29 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 75 30 . . . work_arndyvdyobgtlpeh4rho7pywpi 76 1 Complemen- complemen- NN work_arndyvdyobgtlpeh4rho7pywpi 76 2 tation tation NN work_arndyvdyobgtlpeh4rho7pywpi 76 3 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 76 4 monitored monitor VBN work_arndyvdyobgtlpeh4rho7pywpi 76 5 by by IN work_arndyvdyobgtlpeh4rho7pywpi 76 6 measurement measurement NN work_arndyvdyobgtlpeh4rho7pywpi 76 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 76 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 76 9 incorpo- incorpo- NN work_arndyvdyobgtlpeh4rho7pywpi 76 10 ration ration NN work_arndyvdyobgtlpeh4rho7pywpi 76 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 76 12 labeled label VBN work_arndyvdyobgtlpeh4rho7pywpi 76 13 isovalerate isovalerate NN work_arndyvdyobgtlpeh4rho7pywpi 76 14 into into IN work_arndyvdyobgtlpeh4rho7pywpi 76 15 macromolecules macromolecule NNS work_arndyvdyobgtlpeh4rho7pywpi 76 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 77 1 Fibro- fibro- JJ work_arndyvdyobgtlpeh4rho7pywpi 77 2 blast blast NN work_arndyvdyobgtlpeh4rho7pywpi 77 3 cell cell NN work_arndyvdyobgtlpeh4rho7pywpi 77 4 lines line NNS work_arndyvdyobgtlpeh4rho7pywpi 77 5 deficient deficient JJ work_arndyvdyobgtlpeh4rho7pywpi 77 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 77 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 77 8 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 77 9 degradation degradation NN work_arndyvdyobgtlpeh4rho7pywpi 77 10 – – : work_arndyvdyobgtlpeh4rho7pywpi 77 11 pathway pathway NNP work_arndyvdyobgtlpeh4rho7pywpi 77 12 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 77 13 isovaleryl isovaleryl NNP work_arndyvdyobgtlpeh4rho7pywpi 77 14 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 77 15 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 77 16 dehydrogenase dehydrogenase NN work_arndyvdyobgtlpeh4rho7pywpi 77 17 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 77 18 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 77 19 as as IN work_arndyvdyobgtlpeh4rho7pywpi 77 20 positive positive JJ work_arndyvdyobgtlpeh4rho7pywpi 77 21 controls control NNS work_arndyvdyobgtlpeh4rho7pywpi 77 22 complementing complement VBG work_arndyvdyobgtlpeh4rho7pywpi 77 23 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 77 24 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 77 25 deficient deficient JJ work_arndyvdyobgtlpeh4rho7pywpi 77 26 cell cell NN work_arndyvdyobgtlpeh4rho7pywpi 77 27 lines line NNS work_arndyvdyobgtlpeh4rho7pywpi 77 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 78 1 All all DT work_arndyvdyobgtlpeh4rho7pywpi 78 2 assays assay NNS work_arndyvdyobgtlpeh4rho7pywpi 78 3 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 78 4 done do VBN work_arndyvdyobgtlpeh4rho7pywpi 78 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 78 6 triplicate triplicate NN work_arndyvdyobgtlpeh4rho7pywpi 78 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 78 8 with with IN work_arndyvdyobgtlpeh4rho7pywpi 78 9 stan- stan- NNP work_arndyvdyobgtlpeh4rho7pywpi 78 10 dard dard NNP work_arndyvdyobgtlpeh4rho7pywpi 78 11 deviations deviation NNS work_arndyvdyobgtlpeh4rho7pywpi 78 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 78 13 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 78 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 78 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 78 16 all all DT work_arndyvdyobgtlpeh4rho7pywpi 78 17 cases case NNS work_arndyvdyobgtlpeh4rho7pywpi 78 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 78 19 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 78 20 within within IN work_arndyvdyobgtlpeh4rho7pywpi 78 21 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 78 22 % % NN work_arndyvdyobgtlpeh4rho7pywpi 78 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 78 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 78 25 mean mean JJ work_arndyvdyobgtlpeh4rho7pywpi 78 26 value value NN work_arndyvdyobgtlpeh4rho7pywpi 78 27 . . . work_arndyvdyobgtlpeh4rho7pywpi 79 1 SDS SDS NNP work_arndyvdyobgtlpeh4rho7pywpi 79 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 79 3 PAGE page NN work_arndyvdyobgtlpeh4rho7pywpi 79 4 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 79 5 of of IN work_arndyvdyobgtlpeh4rho7pywpi 79 6 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 79 7 3H]-biotin 3h]-biotin NN work_arndyvdyobgtlpeh4rho7pywpi 79 8 labeled label VBN work_arndyvdyobgtlpeh4rho7pywpi 79 9 mitochondrial mitochondrial NN work_arndyvdyobgtlpeh4rho7pywpi 79 10 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 79 11 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 79 12 as as RB work_arndyvdyobgtlpeh4rho7pywpi 79 13 described describe VBN work_arndyvdyobgtlpeh4rho7pywpi 79 14 elsewhere elsewhere RB work_arndyvdyobgtlpeh4rho7pywpi 79 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 79 16 Lamhonwah Lamhonwah NNP work_arndyvdyobgtlpeh4rho7pywpi 79 17 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 79 18 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 79 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 80 1 1983 1983 CD work_arndyvdyobgtlpeh4rho7pywpi 80 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 80 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 81 1 Immunohistochemical Immunohistochemical NNP work_arndyvdyobgtlpeh4rho7pywpi 81 2 Localization Localization NNP work_arndyvdyobgtlpeh4rho7pywpi 81 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 81 4 hMCCb hMCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 81 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 81 6 Mitochondria Mitochondria NNP work_arndyvdyobgtlpeh4rho7pywpi 81 7 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 81 8 His -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 81 9 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 81 10 tagged tag VBN work_arndyvdyobgtlpeh4rho7pywpi 81 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 81 12 at at IN work_arndyvdyobgtlpeh4rho7pywpi 81 13 its -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 81 14 N N NNP work_arndyvdyobgtlpeh4rho7pywpi 81 15 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 81 16 terminus terminus NN work_arndyvdyobgtlpeh4rho7pywpi 81 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 81 18 hMCCb hmccb CD work_arndyvdyobgtlpeh4rho7pywpi 81 19 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 81 20 con- con- NNP work_arndyvdyobgtlpeh4rho7pywpi 81 21 taining taine VBG work_arndyvdyobgtlpeh4rho7pywpi 81 22 residues residue NNS work_arndyvdyobgtlpeh4rho7pywpi 81 23 33–563 33–563 NNP work_arndyvdyobgtlpeh4rho7pywpi 81 24 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 81 25 expressed express VBN work_arndyvdyobgtlpeh4rho7pywpi 81 26 in in IN work_arndyvdyobgtlpeh4rho7pywpi 81 27 BL21 BL21 NNP work_arndyvdyobgtlpeh4rho7pywpi 81 28 Escher- Escher- NNP work_arndyvdyobgtlpeh4rho7pywpi 81 29 ichia ichia NN work_arndyvdyobgtlpeh4rho7pywpi 81 30 coli coli NNS work_arndyvdyobgtlpeh4rho7pywpi 81 31 cells cell NNS work_arndyvdyobgtlpeh4rho7pywpi 81 32 and and CC work_arndyvdyobgtlpeh4rho7pywpi 81 33 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 81 34 purified purify VBN work_arndyvdyobgtlpeh4rho7pywpi 81 35 by by IN work_arndyvdyobgtlpeh4rho7pywpi 81 36 Ni2 Ni2 NNP work_arndyvdyobgtlpeh4rho7pywpi 81 37 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 81 38 affinity affinity NN work_arndyvdyobgtlpeh4rho7pywpi 81 39 chro- chro- NN work_arndyvdyobgtlpeh4rho7pywpi 81 40 matography matography NN work_arndyvdyobgtlpeh4rho7pywpi 81 41 . . . work_arndyvdyobgtlpeh4rho7pywpi 82 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 82 2 purified purified JJ work_arndyvdyobgtlpeh4rho7pywpi 82 3 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 82 4 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 82 5 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 82 6 to to TO work_arndyvdyobgtlpeh4rho7pywpi 82 7 raise raise VB work_arndyvdyobgtlpeh4rho7pywpi 82 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 82 9 mouse mouse NN work_arndyvdyobgtlpeh4rho7pywpi 82 10 polyclonal polyclonal JJ work_arndyvdyobgtlpeh4rho7pywpi 82 11 antiserum antiserum NN work_arndyvdyobgtlpeh4rho7pywpi 82 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 83 1 This this DT work_arndyvdyobgtlpeh4rho7pywpi 83 2 antiserum antiserum NN work_arndyvdyobgtlpeh4rho7pywpi 83 3 detects detect VBZ work_arndyvdyobgtlpeh4rho7pywpi 83 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 83 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 83 6 western western JJ work_arndyvdyobgtlpeh4rho7pywpi 83 7 blot blot NN work_arndyvdyobgtlpeh4rho7pywpi 83 8 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 83 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 83 10 a a DT work_arndyvdyobgtlpeh4rho7pywpi 83 11 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 83 12 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 83 13 with with IN work_arndyvdyobgtlpeh4rho7pywpi 83 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 83 15 expected expect VBN work_arndyvdyobgtlpeh4rho7pywpi 83 16 electrophoretic electrophoretic JJ work_arndyvdyobgtlpeh4rho7pywpi 83 17 mobility mobility NN work_arndyvdyobgtlpeh4rho7pywpi 83 18 for for IN work_arndyvdyobgtlpeh4rho7pywpi 83 19 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 83 20 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 83 21 . . . work_arndyvdyobgtlpeh4rho7pywpi 84 1 Cultured cultured JJ work_arndyvdyobgtlpeh4rho7pywpi 84 2 hu- hu- CD work_arndyvdyobgtlpeh4rho7pywpi 84 3 man man NN work_arndyvdyobgtlpeh4rho7pywpi 84 4 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 84 5 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 84 6 fixed fix VBN work_arndyvdyobgtlpeh4rho7pywpi 84 7 with with IN work_arndyvdyobgtlpeh4rho7pywpi 84 8 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 84 9 % % NN work_arndyvdyobgtlpeh4rho7pywpi 84 10 paraformaldehyde paraformaldehyde NN work_arndyvdyobgtlpeh4rho7pywpi 84 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 12 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 84 13 treated treat VBN work_arndyvdyobgtlpeh4rho7pywpi 84 14 with with IN work_arndyvdyobgtlpeh4rho7pywpi 84 15 0.5 0.5 CD work_arndyvdyobgtlpeh4rho7pywpi 84 16 % % NN work_arndyvdyobgtlpeh4rho7pywpi 84 17 Triton Triton NNP work_arndyvdyobgtlpeh4rho7pywpi 84 18 X-100 X-100 NNP work_arndyvdyobgtlpeh4rho7pywpi 84 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 84 20 in in IN work_arndyvdyobgtlpeh4rho7pywpi 84 21 PBS PBS NNP work_arndyvdyobgtlpeh4rho7pywpi 84 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 84 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 24 and and CC work_arndyvdyobgtlpeh4rho7pywpi 84 25 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 84 26 incubated incubate VBN work_arndyvdyobgtlpeh4rho7pywpi 84 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 28 for for IN work_arndyvdyobgtlpeh4rho7pywpi 84 29 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 84 30 h h NN work_arndyvdyobgtlpeh4rho7pywpi 84 31 at at IN work_arndyvdyobgtlpeh4rho7pywpi 84 32 37 37 CD work_arndyvdyobgtlpeh4rho7pywpi 84 33 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 84 34 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 84 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 36 with with IN work_arndyvdyobgtlpeh4rho7pywpi 84 37 mouse mouse NN work_arndyvdyobgtlpeh4rho7pywpi 84 38 anti anti NNP work_arndyvdyobgtlpeh4rho7pywpi 84 39 - - NNP work_arndyvdyobgtlpeh4rho7pywpi 84 40 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 84 41 an- an- CC work_arndyvdyobgtlpeh4rho7pywpi 84 42 tiserum tiserum NN work_arndyvdyobgtlpeh4rho7pywpi 84 43 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 84 44 diluted diluted JJ work_arndyvdyobgtlpeh4rho7pywpi 84 45 1:100 1:100 CD work_arndyvdyobgtlpeh4rho7pywpi 84 46 in in IN work_arndyvdyobgtlpeh4rho7pywpi 84 47 50 50 CD work_arndyvdyobgtlpeh4rho7pywpi 84 48 mM mM NNP work_arndyvdyobgtlpeh4rho7pywpi 84 49 Tris Tris NNP work_arndyvdyobgtlpeh4rho7pywpi 84 50 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 84 51 HCl HCl NNP work_arndyvdyobgtlpeh4rho7pywpi 84 52 pH pH NNP work_arndyvdyobgtlpeh4rho7pywpi 84 53 7.4 7.4 CD work_arndyvdyobgtlpeh4rho7pywpi 84 54 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 55 150 150 CD work_arndyvdyobgtlpeh4rho7pywpi 84 56 mM mm NN work_arndyvdyobgtlpeh4rho7pywpi 84 57 NaCl NaCl NNP work_arndyvdyobgtlpeh4rho7pywpi 84 58 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 59 0.2 0.2 CD work_arndyvdyobgtlpeh4rho7pywpi 84 60 % % NN work_arndyvdyobgtlpeh4rho7pywpi 84 61 Tween Tween NNP work_arndyvdyobgtlpeh4rho7pywpi 84 62 20 20 CD work_arndyvdyobgtlpeh4rho7pywpi 84 63 , , , work_arndyvdyobgtlpeh4rho7pywpi 84 64 and and CC work_arndyvdyobgtlpeh4rho7pywpi 84 65 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 84 66 % % NN work_arndyvdyobgtlpeh4rho7pywpi 84 67 bovine bovine NN work_arndyvdyobgtlpeh4rho7pywpi 84 68 serum serum NN work_arndyvdyobgtlpeh4rho7pywpi 84 69 al- al- JJ work_arndyvdyobgtlpeh4rho7pywpi 84 70 bumin bumin NN work_arndyvdyobgtlpeh4rho7pywpi 84 71 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 84 72 . . . work_arndyvdyobgtlpeh4rho7pywpi 85 1 Anti anti JJ work_arndyvdyobgtlpeh4rho7pywpi 85 2 - - NN work_arndyvdyobgtlpeh4rho7pywpi 85 3 mouse mouse JJ work_arndyvdyobgtlpeh4rho7pywpi 85 4 biotinylated biotinylate VBD work_arndyvdyobgtlpeh4rho7pywpi 85 5 secondary secondary JJ work_arndyvdyobgtlpeh4rho7pywpi 85 6 antibody antibody NN work_arndyvdyobgtlpeh4rho7pywpi 85 7 and and CC work_arndyvdyobgtlpeh4rho7pywpi 85 8 Alexa Alexa NNP work_arndyvdyobgtlpeh4rho7pywpi 85 9 488–conjugated 488–conjugated CD work_arndyvdyobgtlpeh4rho7pywpi 85 10 streptavidin streptavidin NNS work_arndyvdyobgtlpeh4rho7pywpi 85 11 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 85 12 from from IN work_arndyvdyobgtlpeh4rho7pywpi 85 13 DAKO DAKO NNP work_arndyvdyobgtlpeh4rho7pywpi 85 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 85 15 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 85 16 Probes Probes NNPS work_arndyvdyobgtlpeh4rho7pywpi 85 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 85 18 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 85 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 86 1 Immunostaining immunostaine VBG work_arndyvdyobgtlpeh4rho7pywpi 86 2 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 86 3 an- an- RB work_arndyvdyobgtlpeh4rho7pywpi 86 4 alyzed alyze VBN work_arndyvdyobgtlpeh4rho7pywpi 86 5 by by IN work_arndyvdyobgtlpeh4rho7pywpi 86 6 means mean NNS work_arndyvdyobgtlpeh4rho7pywpi 86 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 86 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 86 9 confocal confocal JJ work_arndyvdyobgtlpeh4rho7pywpi 86 10 imaging imaging NN work_arndyvdyobgtlpeh4rho7pywpi 86 11 system system NN work_arndyvdyobgtlpeh4rho7pywpi 86 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 87 1 Identification identification NN work_arndyvdyobgtlpeh4rho7pywpi 87 2 of of IN work_arndyvdyobgtlpeh4rho7pywpi 87 3 Mutations Mutations NNPS work_arndyvdyobgtlpeh4rho7pywpi 87 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 87 5 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 87 6 with with IN work_arndyvdyobgtlpeh4rho7pywpi 87 7 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 87 8 All all DT work_arndyvdyobgtlpeh4rho7pywpi 87 9 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 87 10 reported report VBN work_arndyvdyobgtlpeh4rho7pywpi 87 11 here here RB work_arndyvdyobgtlpeh4rho7pywpi 87 12 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 87 13 identified identify VBN work_arndyvdyobgtlpeh4rho7pywpi 87 14 at at IN work_arndyvdyobgtlpeh4rho7pywpi 87 15 both both CC work_arndyvdyobgtlpeh4rho7pywpi 87 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 87 17 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 87 18 level level NN work_arndyvdyobgtlpeh4rho7pywpi 87 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 87 20 the the DT work_arndyvdyobgtlpeh4rho7pywpi 87 21 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 87 22 level level NN work_arndyvdyobgtlpeh4rho7pywpi 87 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 88 1 To to TO work_arndyvdyobgtlpeh4rho7pywpi 88 2 identify identify VB work_arndyvdyobgtlpeh4rho7pywpi 88 3 mu- mu- JJ work_arndyvdyobgtlpeh4rho7pywpi 88 4 tations tation NNS work_arndyvdyobgtlpeh4rho7pywpi 88 5 at at IN work_arndyvdyobgtlpeh4rho7pywpi 88 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 88 7 mRNA mrna JJ work_arndyvdyobgtlpeh4rho7pywpi 88 8 level level NN work_arndyvdyobgtlpeh4rho7pywpi 88 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 88 10 reverse reverse JJ work_arndyvdyobgtlpeh4rho7pywpi 88 11 transcriptase transcriptase NN work_arndyvdyobgtlpeh4rho7pywpi 88 12 – – : work_arndyvdyobgtlpeh4rho7pywpi 88 13 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 88 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 88 15 RT RT NNP work_arndyvdyobgtlpeh4rho7pywpi 88 16 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 88 17 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 88 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 88 19 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 88 20 performed perform VBN work_arndyvdyobgtlpeh4rho7pywpi 88 21 with with IN work_arndyvdyobgtlpeh4rho7pywpi 88 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 88 23 Thermoscript Thermoscript NNP work_arndyvdyobgtlpeh4rho7pywpi 88 24 RT- RT- NNP work_arndyvdyobgtlpeh4rho7pywpi 88 25 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 88 26 System System NNP work_arndyvdyobgtlpeh4rho7pywpi 88 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 88 28 Life Life NNP work_arndyvdyobgtlpeh4rho7pywpi 88 29 Technologies Technologies NNPS work_arndyvdyobgtlpeh4rho7pywpi 88 30 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 88 31 , , , work_arndyvdyobgtlpeh4rho7pywpi 88 32 with with IN work_arndyvdyobgtlpeh4rho7pywpi 88 33 mRNA mRNA NNP work_arndyvdyobgtlpeh4rho7pywpi 88 34 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 88 35 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 88 36 mg mg NNP work_arndyvdyobgtlpeh4rho7pywpi 88 37 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 88 38 iso- iso- UH work_arndyvdyobgtlpeh4rho7pywpi 88 39 lated late VBN work_arndyvdyobgtlpeh4rho7pywpi 88 40 from from IN work_arndyvdyobgtlpeh4rho7pywpi 88 41 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 88 42 of of IN work_arndyvdyobgtlpeh4rho7pywpi 88 43 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 88 44 and and CC work_arndyvdyobgtlpeh4rho7pywpi 88 45 controls control NNS work_arndyvdyobgtlpeh4rho7pywpi 88 46 . . . work_arndyvdyobgtlpeh4rho7pywpi 89 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 89 2 entire entire JJ work_arndyvdyobgtlpeh4rho7pywpi 89 3 coding code VBG work_arndyvdyobgtlpeh4rho7pywpi 89 4 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 89 5 of of IN work_arndyvdyobgtlpeh4rho7pywpi 89 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 89 7 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 89 8 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 89 9 and and CC work_arndyvdyobgtlpeh4rho7pywpi 89 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 89 11 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 89 12 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 89 13 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 89 14 amplified amplify VBN work_arndyvdyobgtlpeh4rho7pywpi 89 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 89 16 seven seven CD work_arndyvdyobgtlpeh4rho7pywpi 89 17 or or CC work_arndyvdyobgtlpeh4rho7pywpi 89 18 six six CD work_arndyvdyobgtlpeh4rho7pywpi 89 19 overlapping overlapping NN work_arndyvdyobgtlpeh4rho7pywpi 89 20 fragments fragment NNS work_arndyvdyobgtlpeh4rho7pywpi 89 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 89 22 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 89 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 89 24 and and CC work_arndyvdyobgtlpeh4rho7pywpi 89 25 subsequently subsequently RB work_arndyvdyobgtlpeh4rho7pywpi 89 26 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 89 27 sequenced sequence VBN work_arndyvdyobgtlpeh4rho7pywpi 89 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 90 1 For for IN work_arndyvdyobgtlpeh4rho7pywpi 90 2 ge- ge- CD work_arndyvdyobgtlpeh4rho7pywpi 90 3 nomic nomic JJ work_arndyvdyobgtlpeh4rho7pywpi 90 4 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 90 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 90 6 exons exon NNS work_arndyvdyobgtlpeh4rho7pywpi 90 7 and and CC work_arndyvdyobgtlpeh4rho7pywpi 90 8 flanking flank VBG work_arndyvdyobgtlpeh4rho7pywpi 90 9 intronic intronic JJ work_arndyvdyobgtlpeh4rho7pywpi 90 10 se- se- NN work_arndyvdyobgtlpeh4rho7pywpi 90 11 quences quence NNS work_arndyvdyobgtlpeh4rho7pywpi 90 12 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 90 13 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 90 14 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 90 15 amplified amplify VBN work_arndyvdyobgtlpeh4rho7pywpi 90 16 by by IN work_arndyvdyobgtlpeh4rho7pywpi 90 17 means mean NNS work_arndyvdyobgtlpeh4rho7pywpi 90 18 of of IN work_arndyvdyobgtlpeh4rho7pywpi 90 19 primers primer NNS work_arndyvdyobgtlpeh4rho7pywpi 90 20 de- de- RB work_arndyvdyobgtlpeh4rho7pywpi 90 21 signed sign VBD work_arndyvdyobgtlpeh4rho7pywpi 90 22 to to TO work_arndyvdyobgtlpeh4rho7pywpi 90 23 be be VB work_arndyvdyobgtlpeh4rho7pywpi 90 24 specific specific JJ work_arndyvdyobgtlpeh4rho7pywpi 90 25 to to IN work_arndyvdyobgtlpeh4rho7pywpi 90 26 the the DT work_arndyvdyobgtlpeh4rho7pywpi 90 27 intronic intronic JJ work_arndyvdyobgtlpeh4rho7pywpi 90 28 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 90 29 sequences sequence NNS work_arndyvdyobgtlpeh4rho7pywpi 90 30 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 90 31 table table NN work_arndyvdyobgtlpeh4rho7pywpi 90 32 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 90 33 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 90 34 . . . work_arndyvdyobgtlpeh4rho7pywpi 91 1 Both both DT work_arndyvdyobgtlpeh4rho7pywpi 91 2 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 91 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 91 4 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 91 5 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 91 6 amplified amplify VBN work_arndyvdyobgtlpeh4rho7pywpi 91 7 fragments fragment NNS work_arndyvdyobgtlpeh4rho7pywpi 91 8 and and CC work_arndyvdyobgtlpeh4rho7pywpi 91 9 SSCP sscp JJ work_arndyvdyobgtlpeh4rho7pywpi 91 10 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 91 11 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 91 12 essentially essentially RB work_arndyvdyobgtlpeh4rho7pywpi 91 13 as as IN work_arndyvdyobgtlpeh4rho7pywpi 91 14 described describe VBN work_arndyvdyobgtlpeh4rho7pywpi 91 15 else- else- NN work_arndyvdyobgtlpeh4rho7pywpi 91 16 where where WRB work_arndyvdyobgtlpeh4rho7pywpi 91 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 91 18 Beltrán Beltrán NNP work_arndyvdyobgtlpeh4rho7pywpi 91 19 Valero Valero NNP work_arndyvdyobgtlpeh4rho7pywpi 91 20 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 91 21 Bernabé Bernabé NNP work_arndyvdyobgtlpeh4rho7pywpi 91 22 et et FW work_arndyvdyobgtlpeh4rho7pywpi 91 23 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 91 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 92 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 92 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 92 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 93 1 To to TO work_arndyvdyobgtlpeh4rho7pywpi 93 2 rule rule VB work_arndyvdyobgtlpeh4rho7pywpi 93 3 out out RP work_arndyvdyobgtlpeh4rho7pywpi 93 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 93 5 possibility possibility NN work_arndyvdyobgtlpeh4rho7pywpi 93 6 that that IN work_arndyvdyobgtlpeh4rho7pywpi 93 7 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 93 8 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 93 9 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 93 10 frequent frequent JJ work_arndyvdyobgtlpeh4rho7pywpi 93 11 polymorphisms polymorphism NNS work_arndyvdyobgtlpeh4rho7pywpi 93 12 in in IN work_arndyvdyobgtlpeh4rho7pywpi 93 13 North north JJ work_arndyvdyobgtlpeh4rho7pywpi 93 14 American american JJ work_arndyvdyobgtlpeh4rho7pywpi 93 15 or or CC work_arndyvdyobgtlpeh4rho7pywpi 93 16 Spanish spanish JJ work_arndyvdyobgtlpeh4rho7pywpi 93 17 popula- popula- JJ work_arndyvdyobgtlpeh4rho7pywpi 93 18 tions tion NNS work_arndyvdyobgtlpeh4rho7pywpi 93 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 93 20 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 93 21 built build VBD work_arndyvdyobgtlpeh4rho7pywpi 93 22 a a DT work_arndyvdyobgtlpeh4rho7pywpi 93 23 control control NN work_arndyvdyobgtlpeh4rho7pywpi 93 24 sample sample NN work_arndyvdyobgtlpeh4rho7pywpi 93 25 including include VBG work_arndyvdyobgtlpeh4rho7pywpi 93 26 1100 1100 CD work_arndyvdyobgtlpeh4rho7pywpi 93 27 chro- chro- NN work_arndyvdyobgtlpeh4rho7pywpi 93 28 mosomes mosome NNS work_arndyvdyobgtlpeh4rho7pywpi 93 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 93 30 using use VBG work_arndyvdyobgtlpeh4rho7pywpi 93 31 anonymous anonymous JJ work_arndyvdyobgtlpeh4rho7pywpi 93 32 donors donor NNS work_arndyvdyobgtlpeh4rho7pywpi 93 33 from from IN work_arndyvdyobgtlpeh4rho7pywpi 93 34 Madrid Madrid NNP work_arndyvdyobgtlpeh4rho7pywpi 93 35 and and CC work_arndyvdyobgtlpeh4rho7pywpi 93 36 New New NNP work_arndyvdyobgtlpeh4rho7pywpi 93 37 York York NNP work_arndyvdyobgtlpeh4rho7pywpi 93 38 . . . work_arndyvdyobgtlpeh4rho7pywpi 94 1 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 94 2 Techniques technique NNS work_arndyvdyobgtlpeh4rho7pywpi 94 3 A a DT work_arndyvdyobgtlpeh4rho7pywpi 94 4 lEMBL4 lembl4 CD work_arndyvdyobgtlpeh4rho7pywpi 94 5 library library NN work_arndyvdyobgtlpeh4rho7pywpi 94 6 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 94 7 screened screen VBN work_arndyvdyobgtlpeh4rho7pywpi 94 8 with with IN work_arndyvdyobgtlpeh4rho7pywpi 94 9 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 94 10 EST est NN work_arndyvdyobgtlpeh4rho7pywpi 94 11 can- can- NN work_arndyvdyobgtlpeh4rho7pywpi 94 12 didates didate NNS work_arndyvdyobgtlpeh4rho7pywpi 94 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 94 14 Fungal Fungal NNP work_arndyvdyobgtlpeh4rho7pywpi 94 15 Genetics Genetics NNP work_arndyvdyobgtlpeh4rho7pywpi 94 16 Stock Stock NNP work_arndyvdyobgtlpeh4rho7pywpi 94 17 Center Center NNP work_arndyvdyobgtlpeh4rho7pywpi 94 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 94 19 for for IN work_arndyvdyobgtlpeh4rho7pywpi 94 20 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 94 21 encod- encod- RB work_arndyvdyobgtlpeh4rho7pywpi 94 22 ing e VBG work_arndyvdyobgtlpeh4rho7pywpi 94 23 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 94 24 or or CC work_arndyvdyobgtlpeh4rho7pywpi 94 25 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 94 26 . . . work_arndyvdyobgtlpeh4rho7pywpi 95 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 95 2 cloned clone VBN work_arndyvdyobgtlpeh4rho7pywpi 95 3 inserts insert NNS work_arndyvdyobgtlpeh4rho7pywpi 95 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 95 5 two two CD work_arndyvdyobgtlpeh4rho7pywpi 95 6 partially partially RB work_arndyvdyobgtlpeh4rho7pywpi 95 7 overlapping overlap VBG work_arndyvdyobgtlpeh4rho7pywpi 95 8 positive positive JJ work_arndyvdyobgtlpeh4rho7pywpi 95 9 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 95 10 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 95 11 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 95 12 to to TO work_arndyvdyobgtlpeh4rho7pywpi 95 13 reconstruct reconstruct VB work_arndyvdyobgtlpeh4rho7pywpi 95 14 a a DT work_arndyvdyobgtlpeh4rho7pywpi 95 15 14-kb 14-kb NNP work_arndyvdyobgtlpeh4rho7pywpi 95 16 region region NN work_arndyvdyobgtlpeh4rho7pywpi 95 17 containing contain VBG work_arndyvdyobgtlpeh4rho7pywpi 95 18 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 95 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 95 20 mccB mccb CD work_arndyvdyobgtlpeh4rho7pywpi 95 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 95 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 95 23 a a DT work_arndyvdyobgtlpeh4rho7pywpi 95 24 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 95 25 iso- iso- NN work_arndyvdyobgtlpeh4rho7pywpi 95 26 valeryl valeryl NN work_arndyvdyobgtlpeh4rho7pywpi 95 27 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 95 28 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 95 29 dehydrogenase dehydrogenase NN work_arndyvdyobgtlpeh4rho7pywpi 95 30 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 95 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 96 1 Intron Intron NNP work_arndyvdyobgtlpeh4rho7pywpi 96 2 positions position NNS work_arndyvdyobgtlpeh4rho7pywpi 96 3 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 96 4 determined determine VBN work_arndyvdyobgtlpeh4rho7pywpi 96 5 by by IN work_arndyvdyobgtlpeh4rho7pywpi 96 6 comparison comparison NN work_arndyvdyobgtlpeh4rho7pywpi 96 7 with with IN work_arndyvdyobgtlpeh4rho7pywpi 96 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 96 9 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 96 10 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 96 11 . . . work_arndyvdyobgtlpeh4rho7pywpi 97 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 97 2 linear linear JJ work_arndyvdyobgtlpeh4rho7pywpi 97 3 fragment fragment NN work_arndyvdyobgtlpeh4rho7pywpi 97 4 containing contain VBG work_arndyvdyobgtlpeh4rho7pywpi 97 5 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 97 6 flanking flanking NN work_arndyvdyobgtlpeh4rho7pywpi 97 7 sequences sequences NNPS work_arndyvdyobgtlpeh4rho7pywpi 97 8 upstream upstream NNP work_arndyvdyobgtlpeh4rho7pywpi 97 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 97 10 1.04 1.04 CD work_arndyvdyobgtlpeh4rho7pywpi 97 11 kb kb NNP work_arndyvdyobgtlpeh4rho7pywpi 97 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 97 13 and and CC work_arndyvdyobgtlpeh4rho7pywpi 97 14 downstream downstream NNP work_arndyvdyobgtlpeh4rho7pywpi 97 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 97 16 1.35 1.35 CD work_arndyvdyobgtlpeh4rho7pywpi 97 17 kb kb NN work_arndyvdyobgtlpeh4rho7pywpi 97 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 97 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 97 20 the the DT work_arndyvdyobgtlpeh4rho7pywpi 97 21 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 97 22 open open JJ work_arndyvdyobgtlpeh4rho7pywpi 97 23 reading reading NN work_arndyvdyobgtlpeh4rho7pywpi 97 24 frame frame NN work_arndyvdyobgtlpeh4rho7pywpi 97 25 in in IN work_arndyvdyobgtlpeh4rho7pywpi 97 26 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 97 27 the the DT work_arndyvdyobgtlpeh4rho7pywpi 97 28 complete complete JJ work_arndyvdyobgtlpeh4rho7pywpi 97 29 mccA mccA HYPH work_arndyvdyobgtlpeh4rho7pywpi 97 30 coding code VBG work_arndyvdyobgtlpeh4rho7pywpi 97 31 region region NN work_arndyvdyobgtlpeh4rho7pywpi 97 32 between between IN work_arndyvdyobgtlpeh4rho7pywpi 97 33 the the DT work_arndyvdyobgtlpeh4rho7pywpi 97 34 initiation initiation NN work_arndyvdyobgtlpeh4rho7pywpi 97 35 and and CC work_arndyvdyobgtlpeh4rho7pywpi 97 36 stop stop VB work_arndyvdyobgtlpeh4rho7pywpi 97 37 codons codon NNS work_arndyvdyobgtlpeh4rho7pywpi 97 38 had have VBD work_arndyvdyobgtlpeh4rho7pywpi 97 39 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 97 40 replaced replace VBN work_arndyvdyobgtlpeh4rho7pywpi 97 41 by by IN work_arndyvdyobgtlpeh4rho7pywpi 97 42 an an DT work_arndyvdyobgtlpeh4rho7pywpi 97 43 argB argB NNS work_arndyvdyobgtlpeh4rho7pywpi 97 44 � � . work_arndyvdyobgtlpeh4rho7pywpi 97 45 allele allele NNP work_arndyvdyobgtlpeh4rho7pywpi 97 46 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 97 47 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 97 48 to to TO work_arndyvdyobgtlpeh4rho7pywpi 97 49 trans- trans- XX work_arndyvdyobgtlpeh4rho7pywpi 97 50 form form VB work_arndyvdyobgtlpeh4rho7pywpi 97 51 an an DT work_arndyvdyobgtlpeh4rho7pywpi 97 52 arginine arginine NN work_arndyvdyobgtlpeh4rho7pywpi 97 53 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 97 54 requiring require VBG work_arndyvdyobgtlpeh4rho7pywpi 97 55 methG1 methG1 NNP work_arndyvdyobgtlpeh4rho7pywpi 97 56 argB2 argb2 ADD work_arndyvdyobgtlpeh4rho7pywpi 97 57 biA1 biA1 NNP work_arndyvdyobgtlpeh4rho7pywpi 97 58 strain strain VBP work_arndyvdyobgtlpeh4rho7pywpi 97 59 to to TO work_arndyvdyobgtlpeh4rho7pywpi 97 60 arginine arginine VB work_arndyvdyobgtlpeh4rho7pywpi 97 61 prototrophy prototrophy NN work_arndyvdyobgtlpeh4rho7pywpi 97 62 . . . work_arndyvdyobgtlpeh4rho7pywpi 98 1 Transformed transform VBN work_arndyvdyobgtlpeh4rho7pywpi 98 2 colonies colony NNS work_arndyvdyobgtlpeh4rho7pywpi 98 3 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 98 4 pu- pu- CD work_arndyvdyobgtlpeh4rho7pywpi 98 5 rified rifie VBN work_arndyvdyobgtlpeh4rho7pywpi 98 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 98 7 minimal minimal JJ work_arndyvdyobgtlpeh4rho7pywpi 98 8 medium medium NN work_arndyvdyobgtlpeh4rho7pywpi 98 9 lacking lack VBG work_arndyvdyobgtlpeh4rho7pywpi 98 10 arginine arginine NN work_arndyvdyobgtlpeh4rho7pywpi 98 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 98 12 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 98 13 an- an- RB work_arndyvdyobgtlpeh4rho7pywpi 98 14 alyzed alyze VBN work_arndyvdyobgtlpeh4rho7pywpi 98 15 by by IN work_arndyvdyobgtlpeh4rho7pywpi 98 16 Southern southern JJ work_arndyvdyobgtlpeh4rho7pywpi 98 17 blot blot NN work_arndyvdyobgtlpeh4rho7pywpi 98 18 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 98 19 using use VBG work_arndyvdyobgtlpeh4rho7pywpi 98 20 mccA- mccA- NNP work_arndyvdyobgtlpeh4rho7pywpi 98 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 98 22 argB- argB- NNP work_arndyvdyobgtlpeh4rho7pywpi 98 23 specific specific JJ work_arndyvdyobgtlpeh4rho7pywpi 98 24 probes probe NNS work_arndyvdyobgtlpeh4rho7pywpi 98 25 to to TO work_arndyvdyobgtlpeh4rho7pywpi 98 26 select select VB work_arndyvdyobgtlpeh4rho7pywpi 98 27 a a DT work_arndyvdyobgtlpeh4rho7pywpi 98 28 number number NN work_arndyvdyobgtlpeh4rho7pywpi 98 29 of of IN work_arndyvdyobgtlpeh4rho7pywpi 98 30 independent independent JJ work_arndyvdyobgtlpeh4rho7pywpi 98 31 transformants transformant NNS work_arndyvdyobgtlpeh4rho7pywpi 98 32 carrying carry VBG work_arndyvdyobgtlpeh4rho7pywpi 98 33 the the DT work_arndyvdyobgtlpeh4rho7pywpi 98 34 expected expected JJ work_arndyvdyobgtlpeh4rho7pywpi 98 35 replacement replacement NN work_arndyvdyobgtlpeh4rho7pywpi 98 36 of of IN work_arndyvdyobgtlpeh4rho7pywpi 98 37 the the DT work_arndyvdyobgtlpeh4rho7pywpi 98 38 resident resident JJ work_arndyvdyobgtlpeh4rho7pywpi 98 39 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 98 40 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 98 41 by by IN work_arndyvdyobgtlpeh4rho7pywpi 98 42 the the DT work_arndyvdyobgtlpeh4rho7pywpi 98 43 argB argB NNS work_arndyvdyobgtlpeh4rho7pywpi 98 44 � � . work_arndyvdyobgtlpeh4rho7pywpi 98 45 allele allele NNP work_arndyvdyobgtlpeh4rho7pywpi 98 46 . . . work_arndyvdyobgtlpeh4rho7pywpi 99 1 All all PDT work_arndyvdyobgtlpeh4rho7pywpi 99 2 these these DT work_arndyvdyobgtlpeh4rho7pywpi 99 3 DmccA DmccA NNP work_arndyvdyobgtlpeh4rho7pywpi 99 4 transformants transformant NNS work_arndyvdyobgtlpeh4rho7pywpi 99 5 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 99 6 phenotypically phenotypically RB work_arndyvdyobgtlpeh4rho7pywpi 99 7 indistinguishable indistinguishable JJ work_arndyvdyobgtlpeh4rho7pywpi 99 8 and and CC work_arndyvdyobgtlpeh4rho7pywpi 99 9 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 99 10 unable unable JJ work_arndyvdyobgtlpeh4rho7pywpi 99 11 to to TO work_arndyvdyobgtlpeh4rho7pywpi 99 12 grow grow VB work_arndyvdyobgtlpeh4rho7pywpi 99 13 on on IN work_arndyvdyobgtlpeh4rho7pywpi 99 14 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 99 15 . . . work_arndyvdyobgtlpeh4rho7pywpi 100 1 An an DT work_arndyvdyobgtlpeh4rho7pywpi 100 2 argB argB NNS work_arndyvdyobgtlpeh4rho7pywpi 100 3 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 100 4 trans- trans- JJ work_arndyvdyobgtlpeh4rho7pywpi 100 5 formant formant NN work_arndyvdyobgtlpeh4rho7pywpi 100 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 100 7 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 100 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 100 9 argB argB NNS work_arndyvdyobgtlpeh4rho7pywpi 100 10 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 100 11 allele allele NNP work_arndyvdyobgtlpeh4rho7pywpi 100 12 had have VBD work_arndyvdyobgtlpeh4rho7pywpi 100 13 replaced replace VBN work_arndyvdyobgtlpeh4rho7pywpi 100 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 100 15 res- res- NNS work_arndyvdyobgtlpeh4rho7pywpi 100 16 ident ident NNP work_arndyvdyobgtlpeh4rho7pywpi 100 17 mutant mutant NNP work_arndyvdyobgtlpeh4rho7pywpi 100 18 argB2 argB2 '' work_arndyvdyobgtlpeh4rho7pywpi 100 19 allele allele NNP work_arndyvdyobgtlpeh4rho7pywpi 100 20 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 100 21 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 100 22 as as IN work_arndyvdyobgtlpeh4rho7pywpi 100 23 an an DT work_arndyvdyobgtlpeh4rho7pywpi 100 24 isogenic isogenic JJ work_arndyvdyobgtlpeh4rho7pywpi 100 25 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 100 26 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 100 27 control control NN work_arndyvdyobgtlpeh4rho7pywpi 100 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 101 1 Growth growth NN work_arndyvdyobgtlpeh4rho7pywpi 101 2 tests test NNS work_arndyvdyobgtlpeh4rho7pywpi 101 3 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 101 4 performed perform VBN work_arndyvdyobgtlpeh4rho7pywpi 101 5 as as IN work_arndyvdyobgtlpeh4rho7pywpi 101 6 described describe VBN work_arndyvdyobgtlpeh4rho7pywpi 101 7 else- else- NN work_arndyvdyobgtlpeh4rho7pywpi 101 8 where where WRB work_arndyvdyobgtlpeh4rho7pywpi 101 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 101 10 Fernández Fernández NNP work_arndyvdyobgtlpeh4rho7pywpi 101 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 101 12 Cañón Cañón NNP work_arndyvdyobgtlpeh4rho7pywpi 101 13 and and CC work_arndyvdyobgtlpeh4rho7pywpi 101 14 Peñalva Peñalva NNP work_arndyvdyobgtlpeh4rho7pywpi 101 15 1995a 1995a CD work_arndyvdyobgtlpeh4rho7pywpi 101 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 101 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 101 18 with with IN work_arndyvdyobgtlpeh4rho7pywpi 101 19 each each DT work_arndyvdyobgtlpeh4rho7pywpi 101 20 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 101 21 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 101 22 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 101 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 101 24 at at IN work_arndyvdyobgtlpeh4rho7pywpi 101 25 30 30 CD work_arndyvdyobgtlpeh4rho7pywpi 101 26 mM mm NN work_arndyvdyobgtlpeh4rho7pywpi 101 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 101 28 as as IN work_arndyvdyobgtlpeh4rho7pywpi 101 29 sole sole JJ work_arndyvdyobgtlpeh4rho7pywpi 101 30 carbon carbon NN work_arndyvdyobgtlpeh4rho7pywpi 101 31 source source NN work_arndyvdyobgtlpeh4rho7pywpi 101 32 . . . work_arndyvdyobgtlpeh4rho7pywpi 102 1 Plates plate NNS work_arndyvdyobgtlpeh4rho7pywpi 102 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 102 3 incubated incubate VBN work_arndyvdyobgtlpeh4rho7pywpi 102 4 for for IN work_arndyvdyobgtlpeh4rho7pywpi 102 5 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 102 6 d d NN work_arndyvdyobgtlpeh4rho7pywpi 102 7 at at IN work_arndyvdyobgtlpeh4rho7pywpi 102 8 37 37 CD work_arndyvdyobgtlpeh4rho7pywpi 102 9 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 102 10 C. C. NNP work_arndyvdyobgtlpeh4rho7pywpi 103 1 Gallardo Gallardo NNP work_arndyvdyobgtlpeh4rho7pywpi 103 2 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 103 3 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 103 4 . . . work_arndyvdyobgtlpeh4rho7pywpi 104 1 : : : work_arndyvdyobgtlpeh4rho7pywpi 104 2 3-Methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 104 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 104 4 CoA coa NN work_arndyvdyobgtlpeh4rho7pywpi 104 5 Carboxylase Carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 104 6 Deficiency Deficiency NNP work_arndyvdyobgtlpeh4rho7pywpi 104 7 337 337 CD work_arndyvdyobgtlpeh4rho7pywpi 104 8 Results Results NNPS work_arndyvdyobgtlpeh4rho7pywpi 104 9 Identification Identification NNP work_arndyvdyobgtlpeh4rho7pywpi 104 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 104 11 Characterization Characterization NNP work_arndyvdyobgtlpeh4rho7pywpi 104 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 104 13 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 104 14 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 104 15 and and CC work_arndyvdyobgtlpeh4rho7pywpi 104 16 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 104 17 cDNAs cDNAs . work_arndyvdyobgtlpeh4rho7pywpi 104 18 The the DT work_arndyvdyobgtlpeh4rho7pywpi 104 19 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 104 20 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 104 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 104 22 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 104 23 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 104 24 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 104 25 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 104 26 number number NN work_arndyvdyobgtlpeh4rho7pywpi 104 27 AF310972 af310972 NN work_arndyvdyobgtlpeh4rho7pywpi 104 28 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 104 29 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 104 30 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 104 31 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 104 32 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 104 33 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 104 34 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 104 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 105 1 1a 1a LS work_arndyvdyobgtlpeh4rho7pywpi 105 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 105 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 105 4 en- en- XX work_arndyvdyobgtlpeh4rho7pywpi 105 5 coding code VBG work_arndyvdyobgtlpeh4rho7pywpi 105 6 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 105 7 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 105 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 105 9 hMCCa hMCCa NNP work_arndyvdyobgtlpeh4rho7pywpi 105 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 105 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 105 12 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 105 13 assembled assemble VBN work_arndyvdyobgtlpeh4rho7pywpi 105 14 by by IN work_arndyvdyobgtlpeh4rho7pywpi 105 15 a a DT work_arndyvdyobgtlpeh4rho7pywpi 105 16 combination combination NN work_arndyvdyobgtlpeh4rho7pywpi 105 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 105 18 dbEST dbest NN work_arndyvdyobgtlpeh4rho7pywpi 105 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 105 20 Expressed express VBN work_arndyvdyobgtlpeh4rho7pywpi 105 21 Sequence Sequence NNP work_arndyvdyobgtlpeh4rho7pywpi 105 22 Tags Tags NNP work_arndyvdyobgtlpeh4rho7pywpi 105 23 data- data- JJ work_arndyvdyobgtlpeh4rho7pywpi 105 24 base base NN work_arndyvdyobgtlpeh4rho7pywpi 105 25 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 105 26 searching searching JJ work_arndyvdyobgtlpeh4rho7pywpi 105 27 and and CC work_arndyvdyobgtlpeh4rho7pywpi 105 28 conventional conventional JJ work_arndyvdyobgtlpeh4rho7pywpi 105 29 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 105 30 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 105 31 of of IN work_arndyvdyobgtlpeh4rho7pywpi 105 32 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 105 33 libraries library NNS work_arndyvdyobgtlpeh4rho7pywpi 105 34 . . . work_arndyvdyobgtlpeh4rho7pywpi 106 1 TBLASTN TBLASTN NNP work_arndyvdyobgtlpeh4rho7pywpi 106 2 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 106 3 BLAST blast NN work_arndyvdyobgtlpeh4rho7pywpi 106 4 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 106 5 searches search NNS work_arndyvdyobgtlpeh4rho7pywpi 106 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 106 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 106 8 hu- hu- JJ work_arndyvdyobgtlpeh4rho7pywpi 106 9 man man NN work_arndyvdyobgtlpeh4rho7pywpi 106 10 dbEST dbest NN work_arndyvdyobgtlpeh4rho7pywpi 106 11 database database NN work_arndyvdyobgtlpeh4rho7pywpi 106 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 106 13 with with IN work_arndyvdyobgtlpeh4rho7pywpi 106 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 106 15 Arabidopsis Arabidopsis NNP work_arndyvdyobgtlpeh4rho7pywpi 106 16 thaliana thaliana NNS work_arndyvdyobgtlpeh4rho7pywpi 106 17 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 106 18 amino amino VBP work_arndyvdyobgtlpeh4rho7pywpi 106 19 acid acid JJ work_arndyvdyobgtlpeh4rho7pywpi 106 20 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 106 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 106 22 Song Song NNP work_arndyvdyobgtlpeh4rho7pywpi 106 23 et et FW work_arndyvdyobgtlpeh4rho7pywpi 106 24 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 106 25 . . . work_arndyvdyobgtlpeh4rho7pywpi 107 1 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 107 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 107 3 used use VBD work_arndyvdyobgtlpeh4rho7pywpi 107 4 as as IN work_arndyvdyobgtlpeh4rho7pywpi 107 5 a a DT work_arndyvdyobgtlpeh4rho7pywpi 107 6 probe probe NN work_arndyvdyobgtlpeh4rho7pywpi 107 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 107 8 identified identify VBN work_arndyvdyobgtlpeh4rho7pywpi 107 9 incomplete incomplete JJ work_arndyvdyobgtlpeh4rho7pywpi 107 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 107 11 at at IN work_arndyvdyobgtlpeh4rho7pywpi 107 12 the the DT work_arndyvdyobgtlpeh4rho7pywpi 107 13 N N NNP work_arndyvdyobgtlpeh4rho7pywpi 107 14 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 107 15 terminal terminal NN work_arndyvdyobgtlpeh4rho7pywpi 107 16 coding coding JJ work_arndyvdyobgtlpeh4rho7pywpi 107 17 region region NN work_arndyvdyobgtlpeh4rho7pywpi 107 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 107 19 uterus uterus NNP work_arndyvdyobgtlpeh4rho7pywpi 107 20 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 107 21 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 107 22 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 107 23 number number NN work_arndyvdyobgtlpeh4rho7pywpi 107 24 AA134548 AA134548 . work_arndyvdyobgtlpeh4rho7pywpi 107 25 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 107 26 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 107 27 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 107 28 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 107 29 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 107 30 1.24 1.24 CD work_arndyvdyobgtlpeh4rho7pywpi 107 31 kb kb NN work_arndyvdyobgtlpeh4rho7pywpi 107 32 , , , work_arndyvdyobgtlpeh4rho7pywpi 107 33 excluding exclude VBG work_arndyvdyobgtlpeh4rho7pywpi 107 34 polyA polyA NNP work_arndyvdyobgtlpeh4rho7pywpi 107 35 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 107 36 and and CC work_arndyvdyobgtlpeh4rho7pywpi 107 37 ad- ad- CC work_arndyvdyobgtlpeh4rho7pywpi 107 38 renal renal JJ work_arndyvdyobgtlpeh4rho7pywpi 107 39 carcinoma carcinoma NN work_arndyvdyobgtlpeh4rho7pywpi 107 40 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 107 41 AA605162 AA605162 NNP work_arndyvdyobgtlpeh4rho7pywpi 107 42 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 107 43 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 107 44 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 107 45 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 107 46 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 107 47 1.74 1.74 CD work_arndyvdyobgtlpeh4rho7pywpi 107 48 kb kb NN work_arndyvdyobgtlpeh4rho7pywpi 107 49 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 107 50 EST EST NNP work_arndyvdyobgtlpeh4rho7pywpi 107 51 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 107 52 . . . work_arndyvdyobgtlpeh4rho7pywpi 108 1 Sequencing sequence VBG work_arndyvdyobgtlpeh4rho7pywpi 108 2 of of IN work_arndyvdyobgtlpeh4rho7pywpi 108 3 these these DT work_arndyvdyobgtlpeh4rho7pywpi 108 4 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 108 5 revealed reveal VBD work_arndyvdyobgtlpeh4rho7pywpi 108 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 108 7 predicted predict VBN work_arndyvdyobgtlpeh4rho7pywpi 108 8 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 108 9 with with IN work_arndyvdyobgtlpeh4rho7pywpi 108 10 a a DT work_arndyvdyobgtlpeh4rho7pywpi 108 11 biotin biotin RB work_arndyvdyobgtlpeh4rho7pywpi 108 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 108 13 binding bind VBG work_arndyvdyobgtlpeh4rho7pywpi 108 14 site site NN work_arndyvdyobgtlpeh4rho7pywpi 108 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 108 16 León León NNP work_arndyvdyobgtlpeh4rho7pywpi 108 17 del del NNP work_arndyvdyobgtlpeh4rho7pywpi 108 18 Rı́o Rı́o NNP work_arndyvdyobgtlpeh4rho7pywpi 108 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 108 20 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 108 21 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 108 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 108 23 whose whose WP$ work_arndyvdyobgtlpeh4rho7pywpi 108 24 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 108 25 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 108 26 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 108 27 differed differ VBN work_arndyvdyobgtlpeh4rho7pywpi 108 28 from from IN work_arndyvdyobgtlpeh4rho7pywpi 108 29 those those DT work_arndyvdyobgtlpeh4rho7pywpi 108 30 of of IN work_arndyvdyobgtlpeh4rho7pywpi 108 31 PCCa PCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 108 32 and and CC work_arndyvdyobgtlpeh4rho7pywpi 108 33 other other JJ work_arndyvdyobgtlpeh4rho7pywpi 108 34 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 108 35 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 108 36 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 108 37 carbox- carbox- NN work_arndyvdyobgtlpeh4rho7pywpi 108 38 ylases ylase NNS work_arndyvdyobgtlpeh4rho7pywpi 108 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 109 1 It -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 109 2 therefore therefore RB work_arndyvdyobgtlpeh4rho7pywpi 109 3 fulfilled fulfil VBD work_arndyvdyobgtlpeh4rho7pywpi 109 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 109 5 criteria criterion NNS work_arndyvdyobgtlpeh4rho7pywpi 109 6 expected expect VBN work_arndyvdyobgtlpeh4rho7pywpi 109 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 109 8 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 109 9 . . . work_arndyvdyobgtlpeh4rho7pywpi 110 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 110 2 largest large JJS work_arndyvdyobgtlpeh4rho7pywpi 110 3 clone clone NN work_arndyvdyobgtlpeh4rho7pywpi 110 4 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 110 5 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 110 6 as as IN work_arndyvdyobgtlpeh4rho7pywpi 110 7 a a DT work_arndyvdyobgtlpeh4rho7pywpi 110 8 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 110 9 32P]-labeled 32p]-labeled CD work_arndyvdyobgtlpeh4rho7pywpi 110 10 probe probe NN work_arndyvdyobgtlpeh4rho7pywpi 110 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 110 12 a a DT work_arndyvdyobgtlpeh4rho7pywpi 110 13 hybridization hybridization NN work_arndyvdyobgtlpeh4rho7pywpi 110 14 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 110 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 110 16 a a DT work_arndyvdyobgtlpeh4rho7pywpi 110 17 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 110 18 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 110 19 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 110 20 library library NN work_arndyvdyobgtlpeh4rho7pywpi 110 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 110 22 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 110 23 failed fail VBD work_arndyvdyobgtlpeh4rho7pywpi 110 24 to to TO work_arndyvdyobgtlpeh4rho7pywpi 110 25 identify identify VB work_arndyvdyobgtlpeh4rho7pywpi 110 26 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 110 27 carrying carry VBG work_arndyvdyobgtlpeh4rho7pywpi 110 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 110 29 translation translation NN work_arndyvdyobgtlpeh4rho7pywpi 110 30 start start NN work_arndyvdyobgtlpeh4rho7pywpi 110 31 codon codon NNP work_arndyvdyobgtlpeh4rho7pywpi 110 32 but but CC work_arndyvdyobgtlpeh4rho7pywpi 110 33 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 110 34 yielded yield VBD work_arndyvdyobgtlpeh4rho7pywpi 110 35 sequences sequence NNS work_arndyvdyobgtlpeh4rho7pywpi 110 36 extending extend VBG work_arndyvdyobgtlpeh4rho7pywpi 110 37 farther far RBR work_arndyvdyobgtlpeh4rho7pywpi 110 38 upstream upstream RB work_arndyvdyobgtlpeh4rho7pywpi 110 39 of of IN work_arndyvdyobgtlpeh4rho7pywpi 110 40 codon codon NNP work_arndyvdyobgtlpeh4rho7pywpi 110 41 218 218 CD work_arndyvdyobgtlpeh4rho7pywpi 110 42 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 110 43 the the DT work_arndyvdyobgtlpeh4rho7pywpi 110 44 most most RBS work_arndyvdyobgtlpeh4rho7pywpi 110 45 N n JJ work_arndyvdyobgtlpeh4rho7pywpi 110 46 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 110 47 terminal terminal NN work_arndyvdyobgtlpeh4rho7pywpi 110 48 codon codon NN work_arndyvdyobgtlpeh4rho7pywpi 110 49 in in IN work_arndyvdyobgtlpeh4rho7pywpi 110 50 the the DT work_arndyvdyobgtlpeh4rho7pywpi 110 51 probe probe NN work_arndyvdyobgtlpeh4rho7pywpi 110 52 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 110 53 . . . work_arndyvdyobgtlpeh4rho7pywpi 111 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 111 2 further further JJ work_arndyvdyobgtlpeh4rho7pywpi 111 3 dbEST dbest NN work_arndyvdyobgtlpeh4rho7pywpi 111 4 search search NN work_arndyvdyobgtlpeh4rho7pywpi 111 5 with with IN work_arndyvdyobgtlpeh4rho7pywpi 111 6 these these DT work_arndyvdyobgtlpeh4rho7pywpi 111 7 sequences sequence NNS work_arndyvdyobgtlpeh4rho7pywpi 111 8 identified identify VBD work_arndyvdyobgtlpeh4rho7pywpi 111 9 a a DT work_arndyvdyobgtlpeh4rho7pywpi 111 10 muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 111 11 EST est NN work_arndyvdyobgtlpeh4rho7pywpi 111 12 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 111 13 AW410916 aw410916 ADD work_arndyvdyobgtlpeh4rho7pywpi 111 14 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 111 15 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 111 16 Over- Over- NNP work_arndyvdyobgtlpeh4rho7pywpi 111 17 view view NN work_arndyvdyobgtlpeh4rho7pywpi 111 18 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 111 19 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 111 20 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 111 21 provided provide VBD work_arndyvdyobgtlpeh4rho7pywpi 111 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 111 23 missing miss VBG work_arndyvdyobgtlpeh4rho7pywpi 111 24 5′ 5′ CD work_arndyvdyobgtlpeh4rho7pywpi 111 25 region region NN work_arndyvdyobgtlpeh4rho7pywpi 111 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 111 27 the the DT work_arndyvdyobgtlpeh4rho7pywpi 111 28 transcript transcript NN work_arndyvdyobgtlpeh4rho7pywpi 111 29 containing contain VBG work_arndyvdyobgtlpeh4rho7pywpi 111 30 the the DT work_arndyvdyobgtlpeh4rho7pywpi 111 31 initiator initiator NN work_arndyvdyobgtlpeh4rho7pywpi 111 32 methionine methionine NNP work_arndyvdyobgtlpeh4rho7pywpi 111 33 codon codon NNP work_arndyvdyobgtlpeh4rho7pywpi 111 34 , , , work_arndyvdyobgtlpeh4rho7pywpi 111 35 as as IN work_arndyvdyobgtlpeh4rho7pywpi 111 36 predicted predict VBD work_arndyvdyobgtlpeh4rho7pywpi 111 37 on on IN work_arndyvdyobgtlpeh4rho7pywpi 111 38 the the DT work_arndyvdyobgtlpeh4rho7pywpi 111 39 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 111 40 of of IN work_arndyvdyobgtlpeh4rho7pywpi 111 41 multiple multiple JJ work_arndyvdyobgtlpeh4rho7pywpi 111 42 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 111 43 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 111 44 alignment alignment NN work_arndyvdyobgtlpeh4rho7pywpi 111 45 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 111 46 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 111 47 not not RB work_arndyvdyobgtlpeh4rho7pywpi 111 48 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 111 49 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 111 50 with with IN work_arndyvdyobgtlpeh4rho7pywpi 111 51 Arabidopsis arabidopsis NN work_arndyvdyobgtlpeh4rho7pywpi 111 52 thaliana thaliana NNS work_arndyvdyobgtlpeh4rho7pywpi 111 53 and and CC work_arndyvdyobgtlpeh4rho7pywpi 111 54 Aspergillus aspergillus NN work_arndyvdyobgtlpeh4rho7pywpi 111 55 nidu- nidu- NN work_arndyvdyobgtlpeh4rho7pywpi 111 56 lans lan NNS work_arndyvdyobgtlpeh4rho7pywpi 111 57 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 111 58 see see VB work_arndyvdyobgtlpeh4rho7pywpi 111 59 below below IN work_arndyvdyobgtlpeh4rho7pywpi 111 60 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 111 61 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 111 62 polypeptides polypeptide NNS work_arndyvdyobgtlpeh4rho7pywpi 111 63 . . . work_arndyvdyobgtlpeh4rho7pywpi 112 1 hMCCa hmcca ADD work_arndyvdyobgtlpeh4rho7pywpi 112 2 contains contain VBZ work_arndyvdyobgtlpeh4rho7pywpi 112 3 725 725 CD work_arndyvdyobgtlpeh4rho7pywpi 112 4 residues residue NNS work_arndyvdyobgtlpeh4rho7pywpi 112 5 and and CC work_arndyvdyobgtlpeh4rho7pywpi 112 6 includes include VBZ work_arndyvdyobgtlpeh4rho7pywpi 112 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 112 8 tetra- tetra- NNP work_arndyvdyobgtlpeh4rho7pywpi 112 9 peptide peptide NN work_arndyvdyobgtlpeh4rho7pywpi 112 10 679-AMKM-682 679-amkm-682 CD work_arndyvdyobgtlpeh4rho7pywpi 112 11 matching match VBG work_arndyvdyobgtlpeh4rho7pywpi 112 12 the the DT work_arndyvdyobgtlpeh4rho7pywpi 112 13 consensus consensus NN work_arndyvdyobgtlpeh4rho7pywpi 112 14 bind- bind- NN work_arndyvdyobgtlpeh4rho7pywpi 112 15 ing e VBG work_arndyvdyobgtlpeh4rho7pywpi 112 16 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 112 17 for for IN work_arndyvdyobgtlpeh4rho7pywpi 112 18 the the DT work_arndyvdyobgtlpeh4rho7pywpi 112 19 essential essential JJ work_arndyvdyobgtlpeh4rho7pywpi 112 20 biotin biotin NNP work_arndyvdyobgtlpeh4rho7pywpi 112 21 cofactor cofactor NNP work_arndyvdyobgtlpeh4rho7pywpi 112 22 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 112 23 León León NNP work_arndyvdyobgtlpeh4rho7pywpi 112 24 del del NNP work_arndyvdyobgtlpeh4rho7pywpi 112 25 Rı́o Rı́o NNP work_arndyvdyobgtlpeh4rho7pywpi 112 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 112 27 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 112 28 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 112 29 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 112 30 , , , work_arndyvdyobgtlpeh4rho7pywpi 112 31 predicted predict VBD work_arndyvdyobgtlpeh4rho7pywpi 112 32 to to TO work_arndyvdyobgtlpeh4rho7pywpi 112 33 be be VB work_arndyvdyobgtlpeh4rho7pywpi 112 34 attached attach VBN work_arndyvdyobgtlpeh4rho7pywpi 112 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 112 36 via via IN work_arndyvdyobgtlpeh4rho7pywpi 112 37 an an DT work_arndyvdyobgtlpeh4rho7pywpi 112 38 amide amide JJ work_arndyvdyobgtlpeh4rho7pywpi 112 39 bond bond NN work_arndyvdyobgtlpeh4rho7pywpi 112 40 , , , work_arndyvdyobgtlpeh4rho7pywpi 112 41 to to IN work_arndyvdyobgtlpeh4rho7pywpi 112 42 the the DT work_arndyvdyobgtlpeh4rho7pywpi 112 43 e e NN work_arndyvdyobgtlpeh4rho7pywpi 112 44 - - NN work_arndyvdyobgtlpeh4rho7pywpi 112 45 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 112 46 group group NN work_arndyvdyobgtlpeh4rho7pywpi 112 47 of of IN work_arndyvdyobgtlpeh4rho7pywpi 112 48 Lys681 Lys681 NNP work_arndyvdyobgtlpeh4rho7pywpi 112 49 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 112 50 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 112 51 . . . work_arndyvdyobgtlpeh4rho7pywpi 113 1 1a 1a LS work_arndyvdyobgtlpeh4rho7pywpi 113 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 113 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 114 1 Residues Residues NNP work_arndyvdyobgtlpeh4rho7pywpi 114 2 50–502 50–502 NNP work_arndyvdyobgtlpeh4rho7pywpi 114 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 114 4 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 114 5 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 114 6 show show VBP work_arndyvdyobgtlpeh4rho7pywpi 114 7 48 48 CD work_arndyvdyobgtlpeh4rho7pywpi 114 8 % % NN work_arndyvdyobgtlpeh4rho7pywpi 114 9 identity identity NN work_arndyvdyobgtlpeh4rho7pywpi 114 10 to to IN work_arndyvdyobgtlpeh4rho7pywpi 114 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 114 12 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 114 13 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 114 14 carboxylating carboxylate VBG work_arndyvdyobgtlpeh4rho7pywpi 114 15 polypeptide polypeptide NN work_arndyvdyobgtlpeh4rho7pywpi 114 16 of of IN work_arndyvdyobgtlpeh4rho7pywpi 114 17 Escherichia Escherichia NNP work_arndyvdyobgtlpeh4rho7pywpi 114 18 coli coli NNS work_arndyvdyobgtlpeh4rho7pywpi 114 19 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 114 20 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 114 21 Waldrop Waldrop NNP work_arndyvdyobgtlpeh4rho7pywpi 114 22 et et FW work_arndyvdyobgtlpeh4rho7pywpi 114 23 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 114 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 115 1 1994 1994 LS work_arndyvdyobgtlpeh4rho7pywpi 115 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 115 3 and and CC work_arndyvdyobgtlpeh4rho7pywpi 115 4 include include VBP work_arndyvdyobgtlpeh4rho7pywpi 115 5 the the DT work_arndyvdyobgtlpeh4rho7pywpi 115 6 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 115 7 209-GGGGKGMR-216 209-ggggkgmr-216 CD work_arndyvdyobgtlpeh4rho7pywpi 115 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 115 9 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 115 10 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 115 11 strongly strongly RB work_arndyvdyobgtlpeh4rho7pywpi 115 12 conserved conserve VBN work_arndyvdyobgtlpeh4rho7pywpi 115 13 among among IN work_arndyvdyobgtlpeh4rho7pywpi 115 14 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 115 15 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 115 16 carboxylating carboxylate VBG work_arndyvdyobgtlpeh4rho7pywpi 115 17 enzymes enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 115 18 . . . work_arndyvdyobgtlpeh4rho7pywpi 116 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 116 2 crystal crystal NN work_arndyvdyobgtlpeh4rho7pywpi 116 3 struc- struc- XX work_arndyvdyobgtlpeh4rho7pywpi 116 4 ture ture NN work_arndyvdyobgtlpeh4rho7pywpi 116 5 of of IN work_arndyvdyobgtlpeh4rho7pywpi 116 6 bacterial bacterial JJ work_arndyvdyobgtlpeh4rho7pywpi 116 7 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 116 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 116 9 Thoden Thoden NNP work_arndyvdyobgtlpeh4rho7pywpi 116 10 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 116 11 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 116 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 117 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 117 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 117 3 revealed reveal VBD work_arndyvdyobgtlpeh4rho7pywpi 117 4 that that IN work_arndyvdyobgtlpeh4rho7pywpi 117 5 this this DT work_arndyvdyobgtlpeh4rho7pywpi 117 6 peptide peptide NN work_arndyvdyobgtlpeh4rho7pywpi 117 7 makes make VBZ work_arndyvdyobgtlpeh4rho7pywpi 117 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 117 9 major major JJ work_arndyvdyobgtlpeh4rho7pywpi 117 10 contribution contribution NN work_arndyvdyobgtlpeh4rho7pywpi 117 11 to to IN work_arndyvdyobgtlpeh4rho7pywpi 117 12 the the DT work_arndyvdyobgtlpeh4rho7pywpi 117 13 ATP- ATP- NNP work_arndyvdyobgtlpeh4rho7pywpi 117 14 binding bind VBG work_arndyvdyobgtlpeh4rho7pywpi 117 15 pocket pocket NN work_arndyvdyobgtlpeh4rho7pywpi 117 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 118 1 hMCCa hmcca ADD work_arndyvdyobgtlpeh4rho7pywpi 118 2 shows show VBZ work_arndyvdyobgtlpeh4rho7pywpi 118 3 ∼42 ∼42 NNP work_arndyvdyobgtlpeh4rho7pywpi 118 4 % % NN work_arndyvdyobgtlpeh4rho7pywpi 118 5 identity identity NN work_arndyvdyobgtlpeh4rho7pywpi 118 6 to to IN work_arndyvdyobgtlpeh4rho7pywpi 118 7 its -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 118 8 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 118 9 homologue homologue NNP work_arndyvdyobgtlpeh4rho7pywpi 118 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 118 11 see see VB work_arndyvdyobgtlpeh4rho7pywpi 118 12 below below RB work_arndyvdyobgtlpeh4rho7pywpi 118 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 118 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 118 15 ∼39 ∼39 NNP work_arndyvdyobgtlpeh4rho7pywpi 118 16 % % NN work_arndyvdyobgtlpeh4rho7pywpi 118 17 identity identity NN work_arndyvdyobgtlpeh4rho7pywpi 118 18 to to IN work_arndyvdyobgtlpeh4rho7pywpi 118 19 hPCCa hpcca ADD work_arndyvdyobgtlpeh4rho7pywpi 118 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 119 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 119 2 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 119 3 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 119 4 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 119 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 119 6 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 119 7 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 119 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 119 9 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 119 10 ini- ini- DT work_arndyvdyobgtlpeh4rho7pywpi 119 11 tially tially RB work_arndyvdyobgtlpeh4rho7pywpi 119 12 identified identify VBN work_arndyvdyobgtlpeh4rho7pywpi 119 13 by by IN work_arndyvdyobgtlpeh4rho7pywpi 119 14 a a DT work_arndyvdyobgtlpeh4rho7pywpi 119 15 search search NN work_arndyvdyobgtlpeh4rho7pywpi 119 16 of of IN work_arndyvdyobgtlpeh4rho7pywpi 119 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 119 18 dbEST dbest NN work_arndyvdyobgtlpeh4rho7pywpi 119 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 119 20 with with IN work_arndyvdyobgtlpeh4rho7pywpi 119 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 119 22 hu- hu- JJ work_arndyvdyobgtlpeh4rho7pywpi 119 23 man man NN work_arndyvdyobgtlpeh4rho7pywpi 119 24 PCCb PCCb NNPS work_arndyvdyobgtlpeh4rho7pywpi 119 25 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 119 26 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 119 27 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 119 28 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 119 29 as as IN work_arndyvdyobgtlpeh4rho7pywpi 119 30 a a DT work_arndyvdyobgtlpeh4rho7pywpi 119 31 probe probe NN work_arndyvdyobgtlpeh4rho7pywpi 119 32 . . . work_arndyvdyobgtlpeh4rho7pywpi 120 1 TBLASTN tblastn NN work_arndyvdyobgtlpeh4rho7pywpi 120 2 searches search NNS work_arndyvdyobgtlpeh4rho7pywpi 120 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 120 4 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 120 5 dbEST dbest NN work_arndyvdyobgtlpeh4rho7pywpi 120 6 identified identify VBD work_arndyvdyobgtlpeh4rho7pywpi 120 7 a a DT work_arndyvdyobgtlpeh4rho7pywpi 120 8 can- can- NN work_arndyvdyobgtlpeh4rho7pywpi 120 9 didate didate NN work_arndyvdyobgtlpeh4rho7pywpi 120 10 clone clone NN work_arndyvdyobgtlpeh4rho7pywpi 120 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 120 12 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 120 13 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 120 14 number number NN work_arndyvdyobgtlpeh4rho7pywpi 120 15 AA465612 aa465612 NN work_arndyvdyobgtlpeh4rho7pywpi 120 16 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 120 17 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 120 18 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 120 19 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 120 20 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 120 21 for for IN work_arndyvdyobgtlpeh4rho7pywpi 120 22 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 120 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 121 1 Although although IN work_arndyvdyobgtlpeh4rho7pywpi 121 2 this this DT work_arndyvdyobgtlpeh4rho7pywpi 121 3 clone clone NN work_arndyvdyobgtlpeh4rho7pywpi 121 4 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 121 5 not not RB work_arndyvdyobgtlpeh4rho7pywpi 121 6 currently currently RB work_arndyvdyobgtlpeh4rho7pywpi 121 7 available available JJ work_arndyvdyobgtlpeh4rho7pywpi 121 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 121 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 121 10 translation translation NN work_arndyvdyobgtlpeh4rho7pywpi 121 11 product product NN work_arndyvdyobgtlpeh4rho7pywpi 121 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 121 13 the the DT work_arndyvdyobgtlpeh4rho7pywpi 121 14 deposited deposit VBN work_arndyvdyobgtlpeh4rho7pywpi 121 15 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 121 16 identified identify VBD work_arndyvdyobgtlpeh4rho7pywpi 121 17 an an DT work_arndyvdyobgtlpeh4rho7pywpi 121 18 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 121 19 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 121 20 EST EST NNP work_arndyvdyobgtlpeh4rho7pywpi 121 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 121 22 for for IN work_arndyvdyobgtlpeh4rho7pywpi 121 23 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 121 24 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 121 25 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 121 26 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 121 27 number number NN work_arndyvdyobgtlpeh4rho7pywpi 121 28 n1c10 n1c10 IN work_arndyvdyobgtlpeh4rho7pywpi 121 29 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 121 30 Fungal Fungal NNP work_arndyvdyobgtlpeh4rho7pywpi 121 31 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 121 32 As- As- NNP work_arndyvdyobgtlpeh4rho7pywpi 121 33 pergillus pergillus JJ work_arndyvdyobgtlpeh4rho7pywpi 121 34 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 121 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 121 36 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 121 37 parasiticus parasiticus NN work_arndyvdyobgtlpeh4rho7pywpi 121 38 , , , work_arndyvdyobgtlpeh4rho7pywpi 121 39 and and CC work_arndyvdyobgtlpeh4rho7pywpi 121 40 Neuro- Neuro- NNP work_arndyvdyobgtlpeh4rho7pywpi 121 41 spora spora NN work_arndyvdyobgtlpeh4rho7pywpi 121 42 crassa crassa NN work_arndyvdyobgtlpeh4rho7pywpi 121 43 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 121 44 Cosmid Cosmid NNP work_arndyvdyobgtlpeh4rho7pywpi 121 45 and and CC work_arndyvdyobgtlpeh4rho7pywpi 121 46 cDNA cdna VB work_arndyvdyobgtlpeh4rho7pywpi 121 47 Sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 121 48 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 121 49 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 121 50 . . . work_arndyvdyobgtlpeh4rho7pywpi 122 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 122 2 a a DT work_arndyvdyobgtlpeh4rho7pywpi 122 3 third third JJ work_arndyvdyobgtlpeh4rho7pywpi 122 4 TBLASTN tblastn NN work_arndyvdyobgtlpeh4rho7pywpi 122 5 search search NN work_arndyvdyobgtlpeh4rho7pywpi 122 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 122 7 this this DT work_arndyvdyobgtlpeh4rho7pywpi 122 8 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 122 9 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 122 10 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 122 11 sequence sequence NNP work_arndyvdyobgtlpeh4rho7pywpi 122 12 iden- iden- NNP work_arndyvdyobgtlpeh4rho7pywpi 122 13 tified tifie VBN work_arndyvdyobgtlpeh4rho7pywpi 122 14 kidney kidney NN work_arndyvdyobgtlpeh4rho7pywpi 122 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 122 16 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 122 17 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 122 18 number number NN work_arndyvdyobgtlpeh4rho7pywpi 122 19 AI949422 ai949422 NN work_arndyvdyobgtlpeh4rho7pywpi 122 20 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 122 21 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 122 22 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 122 23 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 122 24 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 122 25 0.7 0.7 CD work_arndyvdyobgtlpeh4rho7pywpi 122 26 kb kb NN work_arndyvdyobgtlpeh4rho7pywpi 122 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 122 28 and and CC work_arndyvdyobgtlpeh4rho7pywpi 122 29 uterus uterus NNP work_arndyvdyobgtlpeh4rho7pywpi 122 30 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 122 31 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 122 32 ac- ac- IN work_arndyvdyobgtlpeh4rho7pywpi 122 33 cession cession NN work_arndyvdyobgtlpeh4rho7pywpi 122 34 number number NN work_arndyvdyobgtlpeh4rho7pywpi 122 35 AI367183 AI367183 . work_arndyvdyobgtlpeh4rho7pywpi 122 36 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 122 37 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 122 38 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 122 39 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 122 40 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 122 41 1.25 1.25 CD work_arndyvdyobgtlpeh4rho7pywpi 122 42 kb kb NN work_arndyvdyobgtlpeh4rho7pywpi 122 43 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 122 44 ESTs est NNS work_arndyvdyobgtlpeh4rho7pywpi 122 45 , , , work_arndyvdyobgtlpeh4rho7pywpi 122 46 the the DT work_arndyvdyobgtlpeh4rho7pywpi 122 47 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 122 48 of of IN work_arndyvdyobgtlpeh4rho7pywpi 122 49 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 122 50 , , , work_arndyvdyobgtlpeh4rho7pywpi 122 51 combined combine VBN work_arndyvdyobgtlpeh4rho7pywpi 122 52 with with IN work_arndyvdyobgtlpeh4rho7pywpi 122 53 RT- RT- NNP work_arndyvdyobgtlpeh4rho7pywpi 122 54 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 122 55 using use VBG work_arndyvdyobgtlpeh4rho7pywpi 122 56 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 122 57 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 122 58 mRNA mrna NN work_arndyvdyobgtlpeh4rho7pywpi 122 59 , , , work_arndyvdyobgtlpeh4rho7pywpi 122 60 served serve VBD work_arndyvdyobgtlpeh4rho7pywpi 122 61 to to TO work_arndyvdyobgtlpeh4rho7pywpi 122 62 assemble assemble VB work_arndyvdyobgtlpeh4rho7pywpi 122 63 a a DT work_arndyvdyobgtlpeh4rho7pywpi 122 64 full full JJ work_arndyvdyobgtlpeh4rho7pywpi 122 65 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 122 66 length length NN work_arndyvdyobgtlpeh4rho7pywpi 122 67 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 122 68 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 122 69 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 122 70 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 122 71 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 122 72 number number NN work_arndyvdyobgtlpeh4rho7pywpi 122 73 AF310971 af310971 NN work_arndyvdyobgtlpeh4rho7pywpi 122 74 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 122 75 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 122 76 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 122 77 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 122 78 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 122 79 . . . work_arndyvdyobgtlpeh4rho7pywpi 123 1 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 123 2 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 123 3 encodes encode VBZ work_arndyvdyobgtlpeh4rho7pywpi 123 4 a a DT work_arndyvdyobgtlpeh4rho7pywpi 123 5 563-residue 563-residue CD work_arndyvdyobgtlpeh4rho7pywpi 123 6 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 123 7 poly- poly- FW work_arndyvdyobgtlpeh4rho7pywpi 123 8 peptide peptide NN work_arndyvdyobgtlpeh4rho7pywpi 123 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 123 10 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 123 11 . . . work_arndyvdyobgtlpeh4rho7pywpi 124 1 1b 1b NNP work_arndyvdyobgtlpeh4rho7pywpi 124 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 124 3 showing show VBG work_arndyvdyobgtlpeh4rho7pywpi 124 4 59 59 CD work_arndyvdyobgtlpeh4rho7pywpi 124 5 % % NN work_arndyvdyobgtlpeh4rho7pywpi 124 6 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 124 7 identity identity NN work_arndyvdyobgtlpeh4rho7pywpi 124 8 to to IN work_arndyvdyobgtlpeh4rho7pywpi 124 9 its -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 124 10 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 124 11 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 124 12 orthologue orthologue NN work_arndyvdyobgtlpeh4rho7pywpi 124 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 124 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 124 15 mccB mccb CD work_arndyvdyobgtlpeh4rho7pywpi 124 16 product product NN work_arndyvdyobgtlpeh4rho7pywpi 124 17 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 124 18 see see VB work_arndyvdyobgtlpeh4rho7pywpi 124 19 below below RB work_arndyvdyobgtlpeh4rho7pywpi 124 20 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 124 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 124 22 29 29 CD work_arndyvdyobgtlpeh4rho7pywpi 124 23 % % NN work_arndyvdyobgtlpeh4rho7pywpi 124 24 identity identity NN work_arndyvdyobgtlpeh4rho7pywpi 124 25 to to IN work_arndyvdyobgtlpeh4rho7pywpi 124 26 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 124 27 PCCb PCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 124 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 125 1 During during IN work_arndyvdyobgtlpeh4rho7pywpi 125 2 the the DT work_arndyvdyobgtlpeh4rho7pywpi 125 3 course course NN work_arndyvdyobgtlpeh4rho7pywpi 125 4 of of IN work_arndyvdyobgtlpeh4rho7pywpi 125 5 this this DT work_arndyvdyobgtlpeh4rho7pywpi 125 6 work work NN work_arndyvdyobgtlpeh4rho7pywpi 125 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 125 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 125 9 Arabidopsis Arabidopsis NNP work_arndyvdyobgtlpeh4rho7pywpi 125 10 thaliana thaliana FW work_arndyvdyobgtlpeh4rho7pywpi 125 11 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 125 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 125 13 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 125 14 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 125 15 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 125 16 reported report VBN work_arndyvdyobgtlpeh4rho7pywpi 125 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 125 18 McKean mckean UH work_arndyvdyobgtlpeh4rho7pywpi 125 19 et et FW work_arndyvdyobgtlpeh4rho7pywpi 125 20 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 125 21 . . . work_arndyvdyobgtlpeh4rho7pywpi 126 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 126 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 126 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 127 1 Arabidopsis Arabidopsis NNP work_arndyvdyobgtlpeh4rho7pywpi 127 2 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 127 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 127 4 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 127 5 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 127 6 also also RB work_arndyvdyobgtlpeh4rho7pywpi 127 7 59 59 CD work_arndyvdyobgtlpeh4rho7pywpi 127 8 % % NN work_arndyvdyobgtlpeh4rho7pywpi 127 9 identical identical JJ work_arndyvdyobgtlpeh4rho7pywpi 127 10 to to IN work_arndyvdyobgtlpeh4rho7pywpi 127 11 hMCCb hmccb ADD work_arndyvdyobgtlpeh4rho7pywpi 127 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 127 13 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 127 14 con- con- NN work_arndyvdyobgtlpeh4rho7pywpi 127 15 firms firm VBZ work_arndyvdyobgtlpeh4rho7pywpi 127 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 127 17 correct correct JJ work_arndyvdyobgtlpeh4rho7pywpi 127 18 identification identification NN work_arndyvdyobgtlpeh4rho7pywpi 127 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 127 20 the the DT work_arndyvdyobgtlpeh4rho7pywpi 127 21 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 127 22 sequences sequence NNS work_arndyvdyobgtlpeh4rho7pywpi 127 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 128 1 Both both DT work_arndyvdyobgtlpeh4rho7pywpi 128 2 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 128 3 and and CC work_arndyvdyobgtlpeh4rho7pywpi 128 4 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 128 5 contain contain VBP work_arndyvdyobgtlpeh4rho7pywpi 128 6 putative putative JJ work_arndyvdyobgtlpeh4rho7pywpi 128 7 signal signal NN work_arndyvdyobgtlpeh4rho7pywpi 128 8 pep- pep- NN work_arndyvdyobgtlpeh4rho7pywpi 128 9 tides tide NNS work_arndyvdyobgtlpeh4rho7pywpi 128 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 128 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 128 12 agreement agreement NN work_arndyvdyobgtlpeh4rho7pywpi 128 13 with with IN work_arndyvdyobgtlpeh4rho7pywpi 128 14 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 128 15 predicted predict VBN work_arndyvdyobgtlpeh4rho7pywpi 128 16 mitochondrial mitochondrial NN work_arndyvdyobgtlpeh4rho7pywpi 128 17 localization localization NN work_arndyvdyobgtlpeh4rho7pywpi 128 18 . . . work_arndyvdyobgtlpeh4rho7pywpi 129 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 129 2 polyclonal polyclonal JJ work_arndyvdyobgtlpeh4rho7pywpi 129 3 antiserum antiserum NN work_arndyvdyobgtlpeh4rho7pywpi 129 4 raised raise VBN work_arndyvdyobgtlpeh4rho7pywpi 129 5 against against IN work_arndyvdyobgtlpeh4rho7pywpi 129 6 His- His- NNP work_arndyvdyobgtlpeh4rho7pywpi 129 7 tagged tag VBN work_arndyvdyobgtlpeh4rho7pywpi 129 8 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 129 9 purified purify VBN work_arndyvdyobgtlpeh4rho7pywpi 129 10 from from IN work_arndyvdyobgtlpeh4rho7pywpi 129 11 recombinant recombinant JJ work_arndyvdyobgtlpeh4rho7pywpi 129 12 bacteria bacteria NNS work_arndyvdyobgtlpeh4rho7pywpi 129 13 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 129 14 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 129 15 to to TO work_arndyvdyobgtlpeh4rho7pywpi 129 16 confirm confirm VB work_arndyvdyobgtlpeh4rho7pywpi 129 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 129 18 mitochondrial mitochondrial JJ work_arndyvdyobgtlpeh4rho7pywpi 129 19 localization localization NN work_arndyvdyobgtlpeh4rho7pywpi 129 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 129 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 129 22 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 129 23 in in IN work_arndyvdyobgtlpeh4rho7pywpi 129 24 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 129 25 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 129 26 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 129 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 129 28 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 129 29 . . . work_arndyvdyobgtlpeh4rho7pywpi 130 1 1d 1d NNP work_arndyvdyobgtlpeh4rho7pywpi 130 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 130 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 131 1 Structure structure NN work_arndyvdyobgtlpeh4rho7pywpi 131 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 131 3 Chromosomal Chromosomal NNP work_arndyvdyobgtlpeh4rho7pywpi 131 4 Localization Localization NNP work_arndyvdyobgtlpeh4rho7pywpi 131 5 of of IN work_arndyvdyobgtlpeh4rho7pywpi 131 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 131 7 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 131 8 and and CC work_arndyvdyobgtlpeh4rho7pywpi 131 9 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 131 10 Genes Genes NNP work_arndyvdyobgtlpeh4rho7pywpi 131 11 The the DT work_arndyvdyobgtlpeh4rho7pywpi 131 12 intron intron NN work_arndyvdyobgtlpeh4rho7pywpi 131 13 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 131 14 exon exon NNP work_arndyvdyobgtlpeh4rho7pywpi 131 15 organization organization NN work_arndyvdyobgtlpeh4rho7pywpi 131 16 of of IN work_arndyvdyobgtlpeh4rho7pywpi 131 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 131 18 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 131 19 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 131 20 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 131 21 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 131 22 obtained obtain VBN work_arndyvdyobgtlpeh4rho7pywpi 131 23 from from IN work_arndyvdyobgtlpeh4rho7pywpi 131 24 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 131 25 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 131 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 131 27 available available JJ work_arndyvdyobgtlpeh4rho7pywpi 131 28 from from IN work_arndyvdyobgtlpeh4rho7pywpi 131 29 the the DT work_arndyvdyobgtlpeh4rho7pywpi 131 30 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 131 31 Genome Genome NNP work_arndyvdyobgtlpeh4rho7pywpi 131 32 Project Project NNP work_arndyvdyobgtlpeh4rho7pywpi 131 33 , , , work_arndyvdyobgtlpeh4rho7pywpi 131 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 131 35 a a DT work_arndyvdyobgtlpeh4rho7pywpi 131 36 bacterial bacterial JJ work_arndyvdyobgtlpeh4rho7pywpi 131 37 artificial artificial JJ work_arndyvdyobgtlpeh4rho7pywpi 131 38 chro- chro- NN work_arndyvdyobgtlpeh4rho7pywpi 131 39 mosome mosome NN work_arndyvdyobgtlpeh4rho7pywpi 131 40 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 131 41 BAC BAC NNP work_arndyvdyobgtlpeh4rho7pywpi 131 42 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 131 43 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 131 44 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 131 45 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 131 46 number number NN work_arndyvdyobgtlpeh4rho7pywpi 131 47 AC026920 AC026920 . work_arndyvdyobgtlpeh4rho7pywpi 131 48 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 131 49 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 131 50 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 131 51 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 131 52 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 131 53 , , , work_arndyvdyobgtlpeh4rho7pywpi 131 54 and and CC work_arndyvdyobgtlpeh4rho7pywpi 131 55 from from IN work_arndyvdyobgtlpeh4rho7pywpi 131 56 our -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 131 57 sequencing sequence VBG work_arndyvdyobgtlpeh4rho7pywpi 131 58 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 131 59 for for IN work_arndyvdyobgtlpeh4rho7pywpi 131 60 a a DT work_arndyvdyobgtlpeh4rho7pywpi 131 61 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 131 62 PAC PAC NNP work_arndyvdyobgtlpeh4rho7pywpi 131 63 clone clone NN work_arndyvdyobgtlpeh4rho7pywpi 131 64 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 131 65 RZPD RZPD NNP work_arndyvdyobgtlpeh4rho7pywpi 131 66 RPCI-4 RPCI-4 NNP work_arndyvdyobgtlpeh4rho7pywpi 131 67 615H13 615h13 CD work_arndyvdyobgtlpeh4rho7pywpi 131 68 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 131 69 . . . work_arndyvdyobgtlpeh4rho7pywpi 132 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 132 2 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 132 3 MCCA mcca NN work_arndyvdyobgtlpeh4rho7pywpi 132 4 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 132 5 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 132 6 split split VBN work_arndyvdyobgtlpeh4rho7pywpi 132 7 into into IN work_arndyvdyobgtlpeh4rho7pywpi 132 8 19 19 CD work_arndyvdyobgtlpeh4rho7pywpi 132 9 exons exon NNS work_arndyvdyobgtlpeh4rho7pywpi 132 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 132 11 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 132 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 133 1 1c 1c NN work_arndyvdyobgtlpeh4rho7pywpi 133 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 133 3 table table NN work_arndyvdyobgtlpeh4rho7pywpi 133 4 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 133 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 133 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 134 1 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 134 2 mapping map VBG work_arndyvdyobgtlpeh4rho7pywpi 134 3 with with IN work_arndyvdyobgtlpeh4rho7pywpi 134 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 134 5 Stanford Stanford NNP work_arndyvdyobgtlpeh4rho7pywpi 134 6 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 134 7 and and CC work_arndyvdyobgtlpeh4rho7pywpi 134 8 Genebridge Genebridge NNP work_arndyvdyobgtlpeh4rho7pywpi 134 9 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 134 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 134 11 GB4 GB4 NNP work_arndyvdyobgtlpeh4rho7pywpi 134 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 134 13 panels panel NNS work_arndyvdyobgtlpeh4rho7pywpi 134 14 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 134 15 initially initially RB work_arndyvdyobgtlpeh4rho7pywpi 134 16 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 134 17 to to TO work_arndyvdyobgtlpeh4rho7pywpi 134 18 determine determine VB work_arndyvdyobgtlpeh4rho7pywpi 134 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 134 20 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 134 21 ’s ’s POS work_arndyvdyobgtlpeh4rho7pywpi 134 22 chromosomal chromosomal NN work_arndyvdyobgtlpeh4rho7pywpi 134 23 location location NN work_arndyvdyobgtlpeh4rho7pywpi 134 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 135 1 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 135 2 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 135 3 linked link VBN work_arndyvdyobgtlpeh4rho7pywpi 135 4 to to IN work_arndyvdyobgtlpeh4rho7pywpi 135 5 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 135 6 markers marker NNS work_arndyvdyobgtlpeh4rho7pywpi 135 7 mapping map VBG work_arndyvdyobgtlpeh4rho7pywpi 135 8 to to IN work_arndyvdyobgtlpeh4rho7pywpi 135 9 different different JJ work_arndyvdyobgtlpeh4rho7pywpi 135 10 chromosome chromosome NN work_arndyvdyobgtlpeh4rho7pywpi 135 11 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 135 12 locations location NNS work_arndyvdyobgtlpeh4rho7pywpi 135 13 in in IN work_arndyvdyobgtlpeh4rho7pywpi 135 14 either either CC work_arndyvdyobgtlpeh4rho7pywpi 135 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 135 16 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 135 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 135 18 3p11.2-p13 3p11.2-p13 CD work_arndyvdyobgtlpeh4rho7pywpi 135 19 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 135 20 or or CC work_arndyvdyobgtlpeh4rho7pywpi 135 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 135 22 GB4 GB4 NNP work_arndyvdyobgtlpeh4rho7pywpi 135 23 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 135 24 3q25 3q25 CD work_arndyvdyobgtlpeh4rho7pywpi 135 25 - - SYM work_arndyvdyobgtlpeh4rho7pywpi 135 26 27 27 CD work_arndyvdyobgtlpeh4rho7pywpi 135 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 135 28 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 135 29 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 135 30 . . . work_arndyvdyobgtlpeh4rho7pywpi 136 1 To to TO work_arndyvdyobgtlpeh4rho7pywpi 136 2 solve solve VB work_arndyvdyobgtlpeh4rho7pywpi 136 3 this this DT work_arndyvdyobgtlpeh4rho7pywpi 136 4 contradiction contradiction NN work_arndyvdyobgtlpeh4rho7pywpi 136 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 136 6 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 136 7 used use VBD work_arndyvdyobgtlpeh4rho7pywpi 136 8 FISH FISH NNS work_arndyvdyobgtlpeh4rho7pywpi 136 9 . . . work_arndyvdyobgtlpeh4rho7pywpi 137 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 137 2 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 137 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 137 4 125 125 CD work_arndyvdyobgtlpeh4rho7pywpi 137 5 individual individual JJ work_arndyvdyobgtlpeh4rho7pywpi 137 6 metaphases metaphase NNS work_arndyvdyobgtlpeh4rho7pywpi 137 7 from from IN work_arndyvdyobgtlpeh4rho7pywpi 137 8 two two CD work_arndyvdyobgtlpeh4rho7pywpi 137 9 independent independent JJ work_arndyvdyobgtlpeh4rho7pywpi 137 10 ex- ex- JJ work_arndyvdyobgtlpeh4rho7pywpi 137 11 periments periment NNS work_arndyvdyobgtlpeh4rho7pywpi 137 12 unambiguously unambiguously RB work_arndyvdyobgtlpeh4rho7pywpi 137 13 mapped map VBN work_arndyvdyobgtlpeh4rho7pywpi 137 14 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 137 15 to to IN work_arndyvdyobgtlpeh4rho7pywpi 137 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 137 17 telo- telo- XX work_arndyvdyobgtlpeh4rho7pywpi 137 18 meric meric JJ work_arndyvdyobgtlpeh4rho7pywpi 137 19 region region NN work_arndyvdyobgtlpeh4rho7pywpi 137 20 in in IN work_arndyvdyobgtlpeh4rho7pywpi 137 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 137 22 long long JJ work_arndyvdyobgtlpeh4rho7pywpi 137 23 arm arm NN work_arndyvdyobgtlpeh4rho7pywpi 137 24 of of IN work_arndyvdyobgtlpeh4rho7pywpi 137 25 chromosome chromosome NN work_arndyvdyobgtlpeh4rho7pywpi 137 26 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 137 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 137 28 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 137 29 . . . work_arndyvdyobgtlpeh4rho7pywpi 138 1 2 2 LS work_arndyvdyobgtlpeh4rho7pywpi 138 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 138 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 139 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 139 2 conclude conclude VBP work_arndyvdyobgtlpeh4rho7pywpi 139 3 that that IN work_arndyvdyobgtlpeh4rho7pywpi 139 4 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 139 5 maps map NNS work_arndyvdyobgtlpeh4rho7pywpi 139 6 to to IN work_arndyvdyobgtlpeh4rho7pywpi 139 7 3q25 3q25 CD work_arndyvdyobgtlpeh4rho7pywpi 139 8 - - SYM work_arndyvdyobgtlpeh4rho7pywpi 139 9 27 27 CD work_arndyvdyobgtlpeh4rho7pywpi 139 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 139 11 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 139 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 140 1 2A 2a LS work_arndyvdyobgtlpeh4rho7pywpi 140 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 140 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 141 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 141 2 used use VBD work_arndyvdyobgtlpeh4rho7pywpi 141 3 three three CD work_arndyvdyobgtlpeh4rho7pywpi 141 4 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 141 5 Genome Genome NNP work_arndyvdyobgtlpeh4rho7pywpi 141 6 Sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 141 7 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 141 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 141 9 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 141 10 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 141 11 numbers number NNS work_arndyvdyobgtlpeh4rho7pywpi 141 12 AC010279 AC010279 NNP work_arndyvdyobgtlpeh4rho7pywpi 141 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 141 14 AC026775 ac026775 UH work_arndyvdyobgtlpeh4rho7pywpi 141 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 141 16 and and CC work_arndyvdyobgtlpeh4rho7pywpi 141 17 AC025958 AC025958 NNP work_arndyvdyobgtlpeh4rho7pywpi 141 18 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 141 19 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 141 20 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 141 21 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 141 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 141 23 to to TO work_arndyvdyobgtlpeh4rho7pywpi 141 24 determine determine VB work_arndyvdyobgtlpeh4rho7pywpi 141 25 the the DT work_arndyvdyobgtlpeh4rho7pywpi 141 26 structure structure NN work_arndyvdyobgtlpeh4rho7pywpi 141 27 of of IN work_arndyvdyobgtlpeh4rho7pywpi 141 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 141 29 17-exon 17-exon CD work_arndyvdyobgtlpeh4rho7pywpi 141 30 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 141 31 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 141 32 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 141 33 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 141 34 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 141 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 142 1 1c 1c NN work_arndyvdyobgtlpeh4rho7pywpi 142 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 142 3 table table NN work_arndyvdyobgtlpeh4rho7pywpi 142 4 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 142 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 142 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 143 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 143 2 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 143 3 “ " `` work_arndyvdyobgtlpeh4rho7pywpi 143 4 AA465612 aa465612 FW work_arndyvdyobgtlpeh4rho7pywpi 143 5 ” " '' work_arndyvdyobgtlpeh4rho7pywpi 143 6 EST est NN work_arndyvdyobgtlpeh4rho7pywpi 143 7 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 143 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 143 9 in- in- NNP work_arndyvdyobgtlpeh4rho7pywpi 143 10 cluded clude VBD work_arndyvdyobgtlpeh4rho7pywpi 143 11 within within IN work_arndyvdyobgtlpeh4rho7pywpi 143 12 these these DT work_arndyvdyobgtlpeh4rho7pywpi 143 13 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 143 14 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 143 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 143 16 belongs belong VBZ work_arndyvdyobgtlpeh4rho7pywpi 143 17 to to IN work_arndyvdyobgtlpeh4rho7pywpi 143 18 a a DT work_arndyvdyobgtlpeh4rho7pywpi 143 19 UniGene UniGene NNP work_arndyvdyobgtlpeh4rho7pywpi 143 20 cluster cluster NN work_arndyvdyobgtlpeh4rho7pywpi 143 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 143 22 H. H. NNP work_arndyvdyobgtlpeh4rho7pywpi 143 23 167531 167531 CD work_arndyvdyobgtlpeh4rho7pywpi 143 24 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 143 25 STS sts NN work_arndyvdyobgtlpeh4rho7pywpi 143 26 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 143 27 number number NN work_arndyvdyobgtlpeh4rho7pywpi 143 28 SGC34463 SGC34463 NNP work_arndyvdyobgtlpeh4rho7pywpi 143 29 or or CC work_arndyvdyobgtlpeh4rho7pywpi 143 30 338 338 CD work_arndyvdyobgtlpeh4rho7pywpi 143 31 Am Am NNS work_arndyvdyobgtlpeh4rho7pywpi 143 32 . . . work_arndyvdyobgtlpeh4rho7pywpi 144 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 144 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 144 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 145 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 145 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 146 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 146 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 146 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 146 4 Figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 146 5 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 146 6 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 146 7 nucleotide nucleotide JJ work_arndyvdyobgtlpeh4rho7pywpi 146 8 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 146 9 and and CC work_arndyvdyobgtlpeh4rho7pywpi 146 10 intron intron NN work_arndyvdyobgtlpeh4rho7pywpi 146 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 146 12 exon exon NNP work_arndyvdyobgtlpeh4rho7pywpi 146 13 organization organization NN work_arndyvdyobgtlpeh4rho7pywpi 146 14 of of IN work_arndyvdyobgtlpeh4rho7pywpi 146 15 human human NNP work_arndyvdyobgtlpeh4rho7pywpi 146 16 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 146 17 and and CC work_arndyvdyobgtlpeh4rho7pywpi 146 18 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 146 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 147 1 A a NN work_arndyvdyobgtlpeh4rho7pywpi 147 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 147 3 B b NN work_arndyvdyobgtlpeh4rho7pywpi 147 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 147 5 Nucleotide nucleotide JJ work_arndyvdyobgtlpeh4rho7pywpi 147 6 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 147 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 147 8 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 147 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 147 10 A a NN work_arndyvdyobgtlpeh4rho7pywpi 147 11 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 147 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 147 13 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 147 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 147 15 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 147 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 147 17 cDNAs cdna NNS work_arndyvdyobgtlpeh4rho7pywpi 147 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 147 19 with with IN work_arndyvdyobgtlpeh4rho7pywpi 147 20 deduced deduce VBN work_arndyvdyobgtlpeh4rho7pywpi 147 21 translation translation NN work_arndyvdyobgtlpeh4rho7pywpi 147 22 sequences sequence NNS work_arndyvdyobgtlpeh4rho7pywpi 147 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 148 1 Red red JJ work_arndyvdyobgtlpeh4rho7pywpi 148 2 arrowheads arrowhead NNS work_arndyvdyobgtlpeh4rho7pywpi 148 3 indicate indicate VBP work_arndyvdyobgtlpeh4rho7pywpi 148 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 148 5 position position NN work_arndyvdyobgtlpeh4rho7pywpi 148 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 148 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 148 8 introns intron NNS work_arndyvdyobgtlpeh4rho7pywpi 148 9 . . . work_arndyvdyobgtlpeh4rho7pywpi 149 1 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 149 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 149 3 Intron Intron NNP work_arndyvdyobgtlpeh4rho7pywpi 149 4 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 149 5 exon exon NNP work_arndyvdyobgtlpeh4rho7pywpi 149 6 organization organization NN work_arndyvdyobgtlpeh4rho7pywpi 149 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 149 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 149 9 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 149 10 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 149 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 149 12 top top NNP work_arndyvdyobgtlpeh4rho7pywpi 149 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 149 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 149 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 149 16 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 149 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 149 18 bottom bottom NN work_arndyvdyobgtlpeh4rho7pywpi 149 19 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 149 20 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 149 21 . . . work_arndyvdyobgtlpeh4rho7pywpi 150 1 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 150 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 150 3 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 150 4 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 150 5 localizing localize VBG work_arndyvdyobgtlpeh4rho7pywpi 150 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 150 7 mitochondria mitochondria NNP work_arndyvdyobgtlpeh4rho7pywpi 150 8 . . . work_arndyvdyobgtlpeh4rho7pywpi 151 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 151 2 mouse mouse NN work_arndyvdyobgtlpeh4rho7pywpi 151 3 polyclonal polyclonal JJ work_arndyvdyobgtlpeh4rho7pywpi 151 4 antiserum antiserum NN work_arndyvdyobgtlpeh4rho7pywpi 151 5 raised raise VBD work_arndyvdyobgtlpeh4rho7pywpi 151 6 against against IN work_arndyvdyobgtlpeh4rho7pywpi 151 7 histidine histidine NN work_arndyvdyobgtlpeh4rho7pywpi 151 8 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 151 9 tagged tag VBN work_arndyvdyobgtlpeh4rho7pywpi 151 10 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 151 11 purified purify VBN work_arndyvdyobgtlpeh4rho7pywpi 151 12 from from IN work_arndyvdyobgtlpeh4rho7pywpi 151 13 bacteria bacteria NNS work_arndyvdyobgtlpeh4rho7pywpi 151 14 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 151 15 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 151 16 to to TO work_arndyvdyobgtlpeh4rho7pywpi 151 17 reveal reveal VB work_arndyvdyobgtlpeh4rho7pywpi 151 18 the the DT work_arndyvdyobgtlpeh4rho7pywpi 151 19 mitochondrial mitochondrial JJ work_arndyvdyobgtlpeh4rho7pywpi 151 20 localization localization NN work_arndyvdyobgtlpeh4rho7pywpi 151 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 151 22 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 151 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 151 24 in in IN work_arndyvdyobgtlpeh4rho7pywpi 151 25 immunohistochemical immunohistochemical JJ work_arndyvdyobgtlpeh4rho7pywpi 151 26 localization localization NN work_arndyvdyobgtlpeh4rho7pywpi 151 27 experiments experiment NNS work_arndyvdyobgtlpeh4rho7pywpi 151 28 with with IN work_arndyvdyobgtlpeh4rho7pywpi 151 29 cultured cultured JJ work_arndyvdyobgtlpeh4rho7pywpi 151 30 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 151 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 152 1 SHGC-34463 SHGC-34463 NNP work_arndyvdyobgtlpeh4rho7pywpi 152 2 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 152 3 GeneMap’99 GeneMap’99 NNP work_arndyvdyobgtlpeh4rho7pywpi 152 4 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 152 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 152 6 mapping map VBG work_arndyvdyobgtlpeh4rho7pywpi 152 7 either either CC work_arndyvdyobgtlpeh4rho7pywpi 152 8 to to IN work_arndyvdyobgtlpeh4rho7pywpi 152 9 5q12- 5q12- CD work_arndyvdyobgtlpeh4rho7pywpi 152 10 13.1 13.1 CD work_arndyvdyobgtlpeh4rho7pywpi 152 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 152 12 reference reference NN work_arndyvdyobgtlpeh4rho7pywpi 152 13 interval interval NN work_arndyvdyobgtlpeh4rho7pywpi 152 14 D5S637–D5S1977 D5S637–D5S1977 NNP work_arndyvdyobgtlpeh4rho7pywpi 152 15 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 152 16 in in IN work_arndyvdyobgtlpeh4rho7pywpi 152 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 152 18 GB4 GB4 NNP work_arndyvdyobgtlpeh4rho7pywpi 152 19 map map NN work_arndyvdyobgtlpeh4rho7pywpi 152 20 or or CC work_arndyvdyobgtlpeh4rho7pywpi 152 21 to to IN work_arndyvdyobgtlpeh4rho7pywpi 152 22 5q12 5q12 CD work_arndyvdyobgtlpeh4rho7pywpi 152 23 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 152 24 reference reference NN work_arndyvdyobgtlpeh4rho7pywpi 152 25 interval interval NN work_arndyvdyobgtlpeh4rho7pywpi 152 26 D5S647–D5S637 D5S647–D5S637 NNP work_arndyvdyobgtlpeh4rho7pywpi 152 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 152 28 in in IN work_arndyvdyobgtlpeh4rho7pywpi 152 29 the the DT work_arndyvdyobgtlpeh4rho7pywpi 152 30 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 152 31 map map NN work_arndyvdyobgtlpeh4rho7pywpi 152 32 . . . work_arndyvdyobgtlpeh4rho7pywpi 153 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 153 2 agreement agreement NN work_arndyvdyobgtlpeh4rho7pywpi 153 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 153 4 our -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 153 5 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 153 6 experiments experiment NNS work_arndyvdyobgtlpeh4rho7pywpi 153 7 using use VBG work_arndyvdyobgtlpeh4rho7pywpi 153 8 primers primer NNS work_arndyvdyobgtlpeh4rho7pywpi 153 9 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 153 10 generate generate VBP work_arndyvdyobgtlpeh4rho7pywpi 153 11 an an DT work_arndyvdyobgtlpeh4rho7pywpi 153 12 amplicon amplicon NN work_arndyvdyobgtlpeh4rho7pywpi 153 13 in in IN work_arndyvdyobgtlpeh4rho7pywpi 153 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 153 15 3′ 3′ CD work_arndyvdyobgtlpeh4rho7pywpi 153 16 UTR UTR NNP work_arndyvdyobgtlpeh4rho7pywpi 153 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 153 18 exon exon JJ work_arndyvdyobgtlpeh4rho7pywpi 153 19 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 153 20 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 153 21 table table NN work_arndyvdyobgtlpeh4rho7pywpi 153 22 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 153 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 153 24 consistently consistently RB work_arndyvdyobgtlpeh4rho7pywpi 153 25 linked link VBD work_arndyvdyobgtlpeh4rho7pywpi 153 26 the the DT work_arndyvdyobgtlpeh4rho7pywpi 153 27 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 153 28 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 153 29 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 153 30 to to IN work_arndyvdyobgtlpeh4rho7pywpi 153 31 markers marker NNS work_arndyvdyobgtlpeh4rho7pywpi 153 32 mapping mapping NN work_arndyvdyobgtlpeh4rho7pywpi 153 33 to to TO work_arndyvdyobgtlpeh4rho7pywpi 153 34 chromosome chromosome NN work_arndyvdyobgtlpeh4rho7pywpi 153 35 5q12-q13.2 5q12-q13.2 CD work_arndyvdyobgtlpeh4rho7pywpi 153 36 , , , work_arndyvdyobgtlpeh4rho7pywpi 153 37 in in IN work_arndyvdyobgtlpeh4rho7pywpi 153 38 both both CC work_arndyvdyobgtlpeh4rho7pywpi 153 39 the the DT work_arndyvdyobgtlpeh4rho7pywpi 153 40 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 153 41 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 153 42 and and CC work_arndyvdyobgtlpeh4rho7pywpi 153 43 the the DT work_arndyvdyobgtlpeh4rho7pywpi 153 44 GB4 GB4 NNP work_arndyvdyobgtlpeh4rho7pywpi 153 45 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 153 46 . . . work_arndyvdyobgtlpeh4rho7pywpi 154 1 Gallardo Gallardo NNP work_arndyvdyobgtlpeh4rho7pywpi 154 2 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 154 3 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 154 4 . . . work_arndyvdyobgtlpeh4rho7pywpi 155 1 : : : work_arndyvdyobgtlpeh4rho7pywpi 155 2 3-Methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 155 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 155 4 CoA coa NN work_arndyvdyobgtlpeh4rho7pywpi 155 5 Carboxylase Carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 155 6 Deficiency Deficiency NNP work_arndyvdyobgtlpeh4rho7pywpi 155 7 339 339 CD work_arndyvdyobgtlpeh4rho7pywpi 155 8 Table table NN work_arndyvdyobgtlpeh4rho7pywpi 155 9 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 155 10 Structure Structure NNP work_arndyvdyobgtlpeh4rho7pywpi 155 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 155 12 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 155 13 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 155 15 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 155 16 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 155 17 Exon Exon NNP work_arndyvdyobgtlpeh4rho7pywpi 155 18 Size Size NNP work_arndyvdyobgtlpeh4rho7pywpi 155 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 155 20 bp bp NNP work_arndyvdyobgtlpeh4rho7pywpi 155 21 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 155 22 3′ 3′ NNP work_arndyvdyobgtlpeh4rho7pywpi 155 23 Splice Splice NNP work_arndyvdyobgtlpeh4rho7pywpi 155 24 Exon Exon NNP work_arndyvdyobgtlpeh4rho7pywpi 155 25 5′ 5′ CD work_arndyvdyobgtlpeh4rho7pywpi 155 26 Splice Splice NNP work_arndyvdyobgtlpeh4rho7pywpi 155 27 Intron Intron NNP work_arndyvdyobgtlpeh4rho7pywpi 155 28 Size Size NNP work_arndyvdyobgtlpeh4rho7pywpi 155 29 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 155 30 bp bp NN work_arndyvdyobgtlpeh4rho7pywpi 155 31 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 155 32 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 33 : : : work_arndyvdyobgtlpeh4rho7pywpi 155 34 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 155 35 222 222 CD work_arndyvdyobgtlpeh4rho7pywpi 155 36 GCCCAAAGGTAG GCCCAAAGGTAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 37 ....... ....... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 38 CTG CTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 39 CCG CCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 40 CCG CCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 41 AG AG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 42 gtgggtggaggg gtgggtggaggg NN work_arndyvdyobgtlpeh4rho7pywpi 155 43 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 155 44 4,746 4,746 CD work_arndyvdyobgtlpeh4rho7pywpi 155 45 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 155 46 47 47 CD work_arndyvdyobgtlpeh4rho7pywpi 155 47 Tttatgttatag Tttatgttatag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 48 G g NN work_arndyvdyobgtlpeh4rho7pywpi 155 49 ACA ACA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 50 TGG TGG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 51 GTG GTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 52 ......... ......... . work_arndyvdyobgtlpeh4rho7pywpi 155 53 ACA ACA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 54 GCC GCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 55 ACA ACA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 56 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 57 gtactgacagac gtactgacagac VBD work_arndyvdyobgtlpeh4rho7pywpi 155 58 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 155 59 2,014 2,014 CD work_arndyvdyobgtlpeh4rho7pywpi 155 60 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 155 61 137 137 CD work_arndyvdyobgtlpeh4rho7pywpi 155 62 Tgttttaaacag Tgttttaaacag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 63 GA GA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 64 AGA AGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 65 AAC aac NN work_arndyvdyobgtlpeh4rho7pywpi 155 66 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 67 ...... ...... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 68 CAT CAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 69 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 70 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 71 ATG ATG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 72 gtatgtgttaaa gtatgtgttaaa NN work_arndyvdyobgtlpeh4rho7pywpi 155 73 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 155 74 11,867 11,867 CD work_arndyvdyobgtlpeh4rho7pywpi 155 75 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 155 76 96 96 CD work_arndyvdyobgtlpeh4rho7pywpi 155 77 Tttcttaaacag Tttcttaaacag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 78 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 79 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 80 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 81 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 82 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 83 TCT TCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 84 GCT GCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 85 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 86 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 87 gtgagggttgtg gtgagggttgtg VBD work_arndyvdyobgtlpeh4rho7pywpi 155 88 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 155 89 114,033 114,033 CD work_arndyvdyobgtlpeh4rho7pywpi 155 90 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 155 91 122 122 CD work_arndyvdyobgtlpeh4rho7pywpi 155 92 Tctcatttctag Tctcatttctag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 93 GCT GCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 94 ATC ATC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 95 CAT CAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 96 CCA CCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 97 ...... ...... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 98 GGT GGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 99 ATA ATA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 100 AAG AAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 101 AG AG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 102 gtatgagtttat gtatgagtttat NN work_arndyvdyobgtlpeh4rho7pywpi 155 103 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 155 104 1,008 1,008 CD work_arndyvdyobgtlpeh4rho7pywpi 155 105 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 155 106 148 148 CD work_arndyvdyobgtlpeh4rho7pywpi 155 107 Cccactctaaag cccactctaaag NN work_arndyvdyobgtlpeh4rho7pywpi 155 108 C c NN work_arndyvdyobgtlpeh4rho7pywpi 155 109 ACA ACA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 110 TCC tcc NN work_arndyvdyobgtlpeh4rho7pywpi 155 111 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 112 ....... ....... . work_arndyvdyobgtlpeh4rho7pywpi 155 113 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 114 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 115 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 116 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 117 gtaagattgtgc gtaagattgtgc VBP work_arndyvdyobgtlpeh4rho7pywpi 155 118 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 155 119 89 89 CD work_arndyvdyobgtlpeh4rho7pywpi 155 120 7 7 CD work_arndyvdyobgtlpeh4rho7pywpi 155 121 122 122 CD work_arndyvdyobgtlpeh4rho7pywpi 155 122 Tttctctcttag Tttctctcttag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 123 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 124 ATG atg NN work_arndyvdyobgtlpeh4rho7pywpi 155 125 AGG AGG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 126 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 127 ...... ...... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 128 GAC GAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 129 ACA ACA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 130 CCG CCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 131 AG AG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 132 gtgggttggcct gtgggttggcct NN work_arndyvdyobgtlpeh4rho7pywpi 155 133 7 7 CD work_arndyvdyobgtlpeh4rho7pywpi 155 134 15,793 15,793 CD work_arndyvdyobgtlpeh4rho7pywpi 155 135 8 8 CD work_arndyvdyobgtlpeh4rho7pywpi 155 136 112 112 CD work_arndyvdyobgtlpeh4rho7pywpi 155 137 Gcttttatatag Gcttttatatag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 138 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 139 CAT CAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 140 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 141 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 142 ... ... : work_arndyvdyobgtlpeh4rho7pywpi 155 143 GAG GAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 144 GCC GCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 145 CCA CCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 146 GCG GCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 147 gtaaggaccttg gtaaggaccttg NN work_arndyvdyobgtlpeh4rho7pywpi 155 148 8 8 CD work_arndyvdyobgtlpeh4rho7pywpi 155 149 5,000 5,000 CD work_arndyvdyobgtlpeh4rho7pywpi 155 150 9 9 CD work_arndyvdyobgtlpeh4rho7pywpi 155 151 82 82 CD work_arndyvdyobgtlpeh4rho7pywpi 155 152 Tttttttcatag Tttttttcatag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 153 CCT CCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 154 GGT ggt NN work_arndyvdyobgtlpeh4rho7pywpi 155 155 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 156 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 157 ....... ....... . work_arndyvdyobgtlpeh4rho7pywpi 155 158 GTT GTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 159 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 160 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 161 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 162 gtaggttaagat gtaggttaagat NNS work_arndyvdyobgtlpeh4rho7pywpi 155 163 9 9 CD work_arndyvdyobgtlpeh4rho7pywpi 155 164 16,509 16,509 CD work_arndyvdyobgtlpeh4rho7pywpi 155 165 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 155 166 128 128 CD work_arndyvdyobgtlpeh4rho7pywpi 155 167 Tttaccttttag Tttaccttttag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 168 GG GG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 169 ACT ACT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 170 GTG GTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 171 GAG GAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 172 ...... ...... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 173 TGG TGG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 174 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 175 CTT CTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 176 AGA aga DT work_arndyvdyobgtlpeh4rho7pywpi 155 177 gtgagaatattt gtgagaatattt NN work_arndyvdyobgtlpeh4rho7pywpi 155 178 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 155 179 3,662 3,662 CD work_arndyvdyobgtlpeh4rho7pywpi 155 180 11 11 CD work_arndyvdyobgtlpeh4rho7pywpi 155 181 184 184 CD work_arndyvdyobgtlpeh4rho7pywpi 155 182 Ttctattgccag Ttctattgccag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 183 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 184 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 185 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 186 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 187 ....... ....... . work_arndyvdyobgtlpeh4rho7pywpi 155 188 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 189 CGG CGG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 190 CAA CAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 191 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 192 gtaaagtgaaag gtaaagtgaaag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 193 11 11 CD work_arndyvdyobgtlpeh4rho7pywpi 155 194 2,431 2,431 CD work_arndyvdyobgtlpeh4rho7pywpi 155 195 12 12 CD work_arndyvdyobgtlpeh4rho7pywpi 155 196 110 110 CD work_arndyvdyobgtlpeh4rho7pywpi 155 197 Tttcaatttcag Tttcaatttcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 198 GA GA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 199 GAC GAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 200 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 201 GTT GTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 202 ...... ...... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 203 CGT CGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 204 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 205 TAC TAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 206 AAT AAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 207 gtgagtgatctg gtgagtgatctg VBP work_arndyvdyobgtlpeh4rho7pywpi 155 208 12 12 CD work_arndyvdyobgtlpeh4rho7pywpi 155 209 1,591 1,591 CD work_arndyvdyobgtlpeh4rho7pywpi 155 210 13 13 CD work_arndyvdyobgtlpeh4rho7pywpi 155 211 21 21 CD work_arndyvdyobgtlpeh4rho7pywpi 155 212 Ttctcttcctag Ttctcttcctag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 213 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 214 GTT GTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 215 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 216 CTG CTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 217 ....... ....... . work_arndyvdyobgtlpeh4rho7pywpi 155 218 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 219 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 220 CAT CAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 221 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 222 gtatggaaggct gtatggaaggct VBD work_arndyvdyobgtlpeh4rho7pywpi 155 223 13 13 CD work_arndyvdyobgtlpeh4rho7pywpi 155 224 13,054 13,054 CD work_arndyvdyobgtlpeh4rho7pywpi 155 225 14 14 CD work_arndyvdyobgtlpeh4rho7pywpi 155 226 87 87 CD work_arndyvdyobgtlpeh4rho7pywpi 155 227 Aattttttctag Aattttttctag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 228 AT AT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 229 CAA CAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 230 TTC TTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 231 TCT TCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 232 ........ ........ NFP work_arndyvdyobgtlpeh4rho7pywpi 155 233 GGT GGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 234 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 235 AAC AAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 236 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 155 237 gtaagtaatgtt gtaagtaatgtt NN work_arndyvdyobgtlpeh4rho7pywpi 155 238 14 14 CD work_arndyvdyobgtlpeh4rho7pywpi 155 239 111,299 111,299 CD work_arndyvdyobgtlpeh4rho7pywpi 155 240 15 15 CD work_arndyvdyobgtlpeh4rho7pywpi 155 241 50 50 CD work_arndyvdyobgtlpeh4rho7pywpi 155 242 Ttttccataaag Ttttccataaag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 243 AT AT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 244 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 245 GCC GCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 246 ATA ATA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 247 ...... ...... . work_arndyvdyobgtlpeh4rho7pywpi 155 248 TAT TAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 249 AGC AGC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 250 ATG ATG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 251 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 252 gtaagccttact gtaagccttact NN work_arndyvdyobgtlpeh4rho7pywpi 155 253 15 15 CD work_arndyvdyobgtlpeh4rho7pywpi 155 254 3,200 3,200 CD work_arndyvdyobgtlpeh4rho7pywpi 155 255 16 16 CD work_arndyvdyobgtlpeh4rho7pywpi 155 256 138 138 CD work_arndyvdyobgtlpeh4rho7pywpi 155 257 Catttttttcag Catttttttcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 258 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 259 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 260 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 261 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 262 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 263 CTA cta NN work_arndyvdyobgtlpeh4rho7pywpi 155 264 TTT ttt NN work_arndyvdyobgtlpeh4rho7pywpi 155 265 TCC tcc NN work_arndyvdyobgtlpeh4rho7pywpi 155 266 AAG aag NN work_arndyvdyobgtlpeh4rho7pywpi 155 267 gtaatgtctctt gtaatgtctctt NN work_arndyvdyobgtlpeh4rho7pywpi 155 268 16 16 CD work_arndyvdyobgtlpeh4rho7pywpi 155 269 2,179 2,179 CD work_arndyvdyobgtlpeh4rho7pywpi 155 270 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 155 271 108 108 CD work_arndyvdyobgtlpeh4rho7pywpi 155 272 Ttctgtttctag Ttctgtttctag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 273 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 274 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 275 AGT AGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 276 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 277 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 278 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 279 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 280 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 281 AAG AAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 282 gtaatcacatga gtaatcacatga NN work_arndyvdyobgtlpeh4rho7pywpi 155 283 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 155 284 2,792 2,792 CD work_arndyvdyobgtlpeh4rho7pywpi 155 285 18 18 CD work_arndyvdyobgtlpeh4rho7pywpi 155 286 72 72 CD work_arndyvdyobgtlpeh4rho7pywpi 155 287 Ctgaatctcaag Ctgaatctcaag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 288 GTG GTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 289 TTT TTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 290 GTC GTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 291 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 292 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 293 ATG ATG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 294 AAG AAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 295 ATG ATG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 296 GAG GAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 297 gtaaggaaatca gtaaggaaatca VBD work_arndyvdyobgtlpeh4rho7pywpi 155 298 18 18 CD work_arndyvdyobgtlpeh4rho7pywpi 155 299 1,699 1,699 CD work_arndyvdyobgtlpeh4rho7pywpi 155 300 19 19 CD work_arndyvdyobgtlpeh4rho7pywpi 155 301 347 347 CD work_arndyvdyobgtlpeh4rho7pywpi 155 302 Gtgtctctgcag Gtgtctctgcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 303 CAT CAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 304 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 305 ATA ATA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 306 AAG AAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 307 .... .... . work_arndyvdyobgtlpeh4rho7pywpi 155 308 TTTTTATTGGAAGCC TTTTTATTGGAAGCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 309 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 155 310 : : : work_arndyvdyobgtlpeh4rho7pywpi 155 311 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 155 312 237 237 CD work_arndyvdyobgtlpeh4rho7pywpi 155 313 GGGGCTGCAAGG GGGGCTGCAAGG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 314 ...... ...... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 315 GCC GCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 316 CTC CTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 317 TAC TAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 318 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 319 gtaggctgagcg gtaggctgagcg NN work_arndyvdyobgtlpeh4rho7pywpi 155 320 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 155 321 5,368 5,368 CD work_arndyvdyobgtlpeh4rho7pywpi 155 322 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 155 323 67 67 CD work_arndyvdyobgtlpeh4rho7pywpi 155 324 Tttctgttttag Tttctgttttag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 325 GAG GAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 326 AAC AAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 327 TAC TAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 328 ......... ......... . work_arndyvdyobgtlpeh4rho7pywpi 155 329 ATA ATA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 330 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 331 CTA CTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 332 G g NN work_arndyvdyobgtlpeh4rho7pywpi 155 333 gtaaacacagca gtaaacacagca NN work_arndyvdyobgtlpeh4rho7pywpi 155 334 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 155 335 3,285 3,285 CD work_arndyvdyobgtlpeh4rho7pywpi 155 336 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 155 337 85 85 CD work_arndyvdyobgtlpeh4rho7pywpi 155 338 Tttctatcatag tttctatcatag NN work_arndyvdyobgtlpeh4rho7pywpi 155 339 GA GA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 340 GGT GGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 341 GGT GGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 342 ......... ......... . work_arndyvdyobgtlpeh4rho7pywpi 155 343 ATA ATA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 344 GAC GAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 345 CCA CCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 346 GG GG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 347 gtgcgtacatag gtgcgtacatag NN work_arndyvdyobgtlpeh4rho7pywpi 155 348 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 155 349 3,290 3,290 CD work_arndyvdyobgtlpeh4rho7pywpi 155 350 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 155 351 102 102 CD work_arndyvdyobgtlpeh4rho7pywpi 155 352 Tcttcgctttag tcttcgctttag NN work_arndyvdyobgtlpeh4rho7pywpi 155 353 G g NN work_arndyvdyobgtlpeh4rho7pywpi 155 354 TCT TCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 355 CCA CCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 356 TTT ttt NN work_arndyvdyobgtlpeh4rho7pywpi 155 357 ...... ...... . work_arndyvdyobgtlpeh4rho7pywpi 155 358 AGA AGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 359 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 360 TCA TCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 361 GG GG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 362 gtgagtatttac gtgagtatttac NN work_arndyvdyobgtlpeh4rho7pywpi 155 363 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 155 364 2,746 2,746 CD work_arndyvdyobgtlpeh4rho7pywpi 155 365 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 155 366 128 128 CD work_arndyvdyobgtlpeh4rho7pywpi 155 367 Tctgcctttcag Tctgcctttcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 368 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 155 369 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 370 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 371 TGC TGC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 372 ....... ....... . work_arndyvdyobgtlpeh4rho7pywpi 155 373 ATC ATC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 374 TAC TAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 375 TTA TTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 376 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 377 gcaagtcaccag gcaagtcaccag NN work_arndyvdyobgtlpeh4rho7pywpi 155 378 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 155 379 1,720 1,720 CD work_arndyvdyobgtlpeh4rho7pywpi 155 380 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 155 381 113 113 CD work_arndyvdyobgtlpeh4rho7pywpi 155 382 Tcttgtcttcag Tcttgtcttcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 383 TT TT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 384 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 385 TCG TCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 386 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 387 .... .... . work_arndyvdyobgtlpeh4rho7pywpi 155 388 AAT AAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 389 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 390 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 391 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 392 gtaatttttcat gtaatttttcat VBZ work_arndyvdyobgtlpeh4rho7pywpi 155 393 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 155 394 22,183 22,183 CD work_arndyvdyobgtlpeh4rho7pywpi 155 395 7 7 CD work_arndyvdyobgtlpeh4rho7pywpi 155 396 114 114 CD work_arndyvdyobgtlpeh4rho7pywpi 155 397 Cttggattccag Cttggattccag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 398 ATC ATC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 399 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 400 GTG GTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 401 ....... ....... . work_arndyvdyobgtlpeh4rho7pywpi 155 402 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 403 CCC CCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 404 CCC CCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 405 TTG TTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 406 gtaagaacataa gtaagaacataa NN work_arndyvdyobgtlpeh4rho7pywpi 155 407 7 7 CD work_arndyvdyobgtlpeh4rho7pywpi 155 408 5,367 5,367 CD work_arndyvdyobgtlpeh4rho7pywpi 155 409 8 8 CD work_arndyvdyobgtlpeh4rho7pywpi 155 410 65 65 CD work_arndyvdyobgtlpeh4rho7pywpi 155 411 Tccttgttgtag tccttgttgtag JJ work_arndyvdyobgtlpeh4rho7pywpi 155 412 GTT GTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 413 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 414 GCG GCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 415 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 416 .... .... NFP work_arndyvdyobgtlpeh4rho7pywpi 155 417 CTT CTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 418 CAT CAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 419 TGC TGC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 420 AG AG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 421 gtgaaacagaaa gtgaaacagaaa NNP work_arndyvdyobgtlpeh4rho7pywpi 155 422 8 8 CD work_arndyvdyobgtlpeh4rho7pywpi 155 423 2,767 2,767 CD work_arndyvdyobgtlpeh4rho7pywpi 155 424 9 9 CD work_arndyvdyobgtlpeh4rho7pywpi 155 425 100 100 CD work_arndyvdyobgtlpeh4rho7pywpi 155 426 Cttattctgtag Cttattctgtag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 427 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 155 428 AAG aag NN work_arndyvdyobgtlpeh4rho7pywpi 155 429 TCT TCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 430 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 431 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 432 AAG aag VB work_arndyvdyobgtlpeh4rho7pywpi 155 433 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 434 TTG TTG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 435 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 436 gtgagtacgata gtgagtacgata NN work_arndyvdyobgtlpeh4rho7pywpi 155 437 9 9 CD work_arndyvdyobgtlpeh4rho7pywpi 155 438 108 108 CD work_arndyvdyobgtlpeh4rho7pywpi 155 439 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 155 440 96 96 CD work_arndyvdyobgtlpeh4rho7pywpi 155 441 Gtatttctgcag Gtatttctgcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 442 GTC GTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 443 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 444 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 445 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 446 ... ... : work_arndyvdyobgtlpeh4rho7pywpi 155 447 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 448 GTC GTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 449 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 450 GAG GAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 451 gtatgtgaaagt gtatgtgaaagt NN work_arndyvdyobgtlpeh4rho7pywpi 155 452 10 10 CD work_arndyvdyobgtlpeh4rho7pywpi 155 453 5,753 5,753 CD work_arndyvdyobgtlpeh4rho7pywpi 155 454 11 11 CD work_arndyvdyobgtlpeh4rho7pywpi 155 455 73 73 CD work_arndyvdyobgtlpeh4rho7pywpi 155 456 Ttttcctcttag Ttttcctcttag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 457 GTC GTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 458 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 459 GCT GCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 460 AGA AGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 461 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 462 TTA TTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 463 GTT GTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 464 ACA ACA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 465 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 466 gtataaaggtga gtataaaggtga NN work_arndyvdyobgtlpeh4rho7pywpi 155 467 11 11 CD work_arndyvdyobgtlpeh4rho7pywpi 155 468 2,743 2,743 CD work_arndyvdyobgtlpeh4rho7pywpi 155 469 12 12 CD work_arndyvdyobgtlpeh4rho7pywpi 155 470 77 77 CD work_arndyvdyobgtlpeh4rho7pywpi 155 471 Ctttcttttgag Ctttcttttgag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 472 GA GA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 473 TTT TTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 474 GCT GCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 475 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 476 .... .... . work_arndyvdyobgtlpeh4rho7pywpi 155 477 TCT TCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 478 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 479 AAA AAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 480 AAG AAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 481 gcaagtactgtt gcaagtactgtt NN work_arndyvdyobgtlpeh4rho7pywpi 155 482 12 12 CD work_arndyvdyobgtlpeh4rho7pywpi 155 483 2,320 2,320 CD work_arndyvdyobgtlpeh4rho7pywpi 155 484 13 13 CD work_arndyvdyobgtlpeh4rho7pywpi 155 485 67 67 CD work_arndyvdyobgtlpeh4rho7pywpi 155 486 Atttgcttatag Atttgcttatag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 487 GGT GGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 488 ACT ACT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 489 CAC CAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 490 TTT TTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 491 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 492 AAC AAC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 493 ATT ATT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 494 ACT ACT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 495 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 496 gtaagaaaatag gtaagaaaatag VBP work_arndyvdyobgtlpeh4rho7pywpi 155 497 13 13 CD work_arndyvdyobgtlpeh4rho7pywpi 155 498 2,818 2,818 CD work_arndyvdyobgtlpeh4rho7pywpi 155 499 14 14 CD work_arndyvdyobgtlpeh4rho7pywpi 155 500 157 157 CD work_arndyvdyobgtlpeh4rho7pywpi 155 501 Tctttctctcag tctttctctcag NN work_arndyvdyobgtlpeh4rho7pywpi 155 502 GA GA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 503 TTT TTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 504 ATG ATG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 505 GTT GTT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 506 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 507 AGA AGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 508 GCG GCG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 509 TAT TAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 510 AG AG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 511 gtaggtgtcatg gtaggtgtcatg NNS work_arndyvdyobgtlpeh4rho7pywpi 155 512 14 14 CD work_arndyvdyobgtlpeh4rho7pywpi 155 513 815 815 CD work_arndyvdyobgtlpeh4rho7pywpi 155 514 15 15 CD work_arndyvdyobgtlpeh4rho7pywpi 155 515 115 115 CD work_arndyvdyobgtlpeh4rho7pywpi 155 516 Ttcttcccccag Ttcttcccccag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 517 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 155 518 CCA cca VB work_arndyvdyobgtlpeh4rho7pywpi 155 519 AGA aga JJ work_arndyvdyobgtlpeh4rho7pywpi 155 520 TTT ttt NN work_arndyvdyobgtlpeh4rho7pywpi 155 521 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 522 GAA GAA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 523 GGA GGA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 524 AAG AAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 525 CAG CAG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 526 gtcggtgtcgtt gtcggtgtcgtt NN work_arndyvdyobgtlpeh4rho7pywpi 155 527 15 15 CD work_arndyvdyobgtlpeh4rho7pywpi 155 528 2,485 2,485 CD work_arndyvdyobgtlpeh4rho7pywpi 155 529 16 16 CD work_arndyvdyobgtlpeh4rho7pywpi 155 530 86 86 CD work_arndyvdyobgtlpeh4rho7pywpi 155 531 Cttttcctttag Cttttcctttag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 532 TTC TTC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 533 TCC TCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 534 AGT AGT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 535 GCT GCT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 536 .... .... . work_arndyvdyobgtlpeh4rho7pywpi 155 537 TCC TCC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 538 AGC AGC NNP work_arndyvdyobgtlpeh4rho7pywpi 155 539 GCA GCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 540 AG AG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 541 gtgggggccaga gtgggggccaga NNS work_arndyvdyobgtlpeh4rho7pywpi 155 542 16 16 CD work_arndyvdyobgtlpeh4rho7pywpi 155 543 3,987 3,987 CD work_arndyvdyobgtlpeh4rho7pywpi 155 544 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 155 545 475 475 CD work_arndyvdyobgtlpeh4rho7pywpi 155 546 Ttcttttgtcag Ttcttttgtcag NNP work_arndyvdyobgtlpeh4rho7pywpi 155 547 G G NNP work_arndyvdyobgtlpeh4rho7pywpi 155 548 GTA GTA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 549 TGG TGG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 550 GAT GAT NNP work_arndyvdyobgtlpeh4rho7pywpi 155 551 ..... ..... . work_arndyvdyobgtlpeh4rho7pywpi 155 552 ATTTTCACTGAAATG ATTTTCACTGAAATG NNP work_arndyvdyobgtlpeh4rho7pywpi 155 553 Transcription Transcription NNP work_arndyvdyobgtlpeh4rho7pywpi 155 554 Pattern Pattern NNP work_arndyvdyobgtlpeh4rho7pywpi 155 555 of of IN work_arndyvdyobgtlpeh4rho7pywpi 155 556 the the DT work_arndyvdyobgtlpeh4rho7pywpi 155 557 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 155 558 and and CC work_arndyvdyobgtlpeh4rho7pywpi 155 559 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 155 560 Genes Genes NNPS work_arndyvdyobgtlpeh4rho7pywpi 155 561 : : : work_arndyvdyobgtlpeh4rho7pywpi 155 562 Agreement agreement NN work_arndyvdyobgtlpeh4rho7pywpi 155 563 with with IN work_arndyvdyobgtlpeh4rho7pywpi 155 564 the the DT work_arndyvdyobgtlpeh4rho7pywpi 155 565 Predicted Predicted NNP work_arndyvdyobgtlpeh4rho7pywpi 155 566 Physiological Physiological NNP work_arndyvdyobgtlpeh4rho7pywpi 155 567 Role Role NNP work_arndyvdyobgtlpeh4rho7pywpi 155 568 Unlike unlike IN work_arndyvdyobgtlpeh4rho7pywpi 155 569 most most JJS work_arndyvdyobgtlpeh4rho7pywpi 155 570 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 155 571 acids acid NNS work_arndyvdyobgtlpeh4rho7pywpi 155 572 absorbed absorb VBN work_arndyvdyobgtlpeh4rho7pywpi 155 573 across across IN work_arndyvdyobgtlpeh4rho7pywpi 155 574 the the DT work_arndyvdyobgtlpeh4rho7pywpi 155 575 intestine intestine NN work_arndyvdyobgtlpeh4rho7pywpi 155 576 , , , work_arndyvdyobgtlpeh4rho7pywpi 155 577 the the DT work_arndyvdyobgtlpeh4rho7pywpi 155 578 branched branch VBN work_arndyvdyobgtlpeh4rho7pywpi 155 579 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 155 580 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 155 581 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 155 582 acids acid NNS work_arndyvdyobgtlpeh4rho7pywpi 155 583 leucine leucine NNP work_arndyvdyobgtlpeh4rho7pywpi 155 584 , , , work_arndyvdyobgtlpeh4rho7pywpi 155 585 valine valine NN work_arndyvdyobgtlpeh4rho7pywpi 155 586 , , , work_arndyvdyobgtlpeh4rho7pywpi 155 587 and and CC work_arndyvdyobgtlpeh4rho7pywpi 155 588 iso- iso- RB work_arndyvdyobgtlpeh4rho7pywpi 155 589 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 155 590 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 155 591 not not RB work_arndyvdyobgtlpeh4rho7pywpi 155 592 taken take VBN work_arndyvdyobgtlpeh4rho7pywpi 155 593 up up RP work_arndyvdyobgtlpeh4rho7pywpi 155 594 to to IN work_arndyvdyobgtlpeh4rho7pywpi 155 595 any any DT work_arndyvdyobgtlpeh4rho7pywpi 155 596 great great JJ work_arndyvdyobgtlpeh4rho7pywpi 155 597 extent extent NN work_arndyvdyobgtlpeh4rho7pywpi 155 598 by by IN work_arndyvdyobgtlpeh4rho7pywpi 155 599 the the DT work_arndyvdyobgtlpeh4rho7pywpi 155 600 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 155 601 , , , work_arndyvdyobgtlpeh4rho7pywpi 155 602 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 155 603 leads lead VBZ work_arndyvdyobgtlpeh4rho7pywpi 155 604 to to IN work_arndyvdyobgtlpeh4rho7pywpi 155 605 a a DT work_arndyvdyobgtlpeh4rho7pywpi 155 606 large large JJ work_arndyvdyobgtlpeh4rho7pywpi 155 607 increment increment NN work_arndyvdyobgtlpeh4rho7pywpi 155 608 in in IN work_arndyvdyobgtlpeh4rho7pywpi 155 609 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 155 610 arterial arterial JJ work_arndyvdyobgtlpeh4rho7pywpi 155 611 con- con- NN work_arndyvdyobgtlpeh4rho7pywpi 155 612 centration centration NN work_arndyvdyobgtlpeh4rho7pywpi 155 613 after after IN work_arndyvdyobgtlpeh4rho7pywpi 155 614 a a DT work_arndyvdyobgtlpeh4rho7pywpi 155 615 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 155 616 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 155 617 rich rich JJ work_arndyvdyobgtlpeh4rho7pywpi 155 618 meal meal NN work_arndyvdyobgtlpeh4rho7pywpi 155 619 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 155 620 Wahren Wahren NNP work_arndyvdyobgtlpeh4rho7pywpi 155 621 et et FW work_arndyvdyobgtlpeh4rho7pywpi 155 622 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 155 623 . . . work_arndyvdyobgtlpeh4rho7pywpi 156 1 1976 1976 CD work_arndyvdyobgtlpeh4rho7pywpi 156 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 156 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 157 1 Muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 157 2 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 157 3 the the DT work_arndyvdyobgtlpeh4rho7pywpi 157 4 primary primary JJ work_arndyvdyobgtlpeh4rho7pywpi 157 5 site site NN work_arndyvdyobgtlpeh4rho7pywpi 157 6 for for IN work_arndyvdyobgtlpeh4rho7pywpi 157 7 branched branched NN work_arndyvdyobgtlpeh4rho7pywpi 157 8 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 157 9 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 157 10 – – : work_arndyvdyobgtlpeh4rho7pywpi 157 11 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 157 12 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 157 13 transamination transamination NNP work_arndyvdyobgtlpeh4rho7pywpi 157 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 157 15 Goldberg Goldberg NNP work_arndyvdyobgtlpeh4rho7pywpi 157 16 and and CC work_arndyvdyobgtlpeh4rho7pywpi 157 17 Chang Chang NNP work_arndyvdyobgtlpeh4rho7pywpi 157 18 1978 1978 CD work_arndyvdyobgtlpeh4rho7pywpi 157 19 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 157 20 Chuang Chuang NNP work_arndyvdyobgtlpeh4rho7pywpi 157 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 157 22 Shih Shih NNP work_arndyvdyobgtlpeh4rho7pywpi 157 23 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 157 24 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 157 25 . . . work_arndyvdyobgtlpeh4rho7pywpi 158 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 158 2 resulting result VBG work_arndyvdyobgtlpeh4rho7pywpi 158 3 branched branch VBN work_arndyvdyobgtlpeh4rho7pywpi 158 4 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 158 5 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 158 6 ketoacids ketoacid NNS work_arndyvdyobgtlpeh4rho7pywpi 158 7 can can MD work_arndyvdyobgtlpeh4rho7pywpi 158 8 be be VB work_arndyvdyobgtlpeh4rho7pywpi 158 9 either either CC work_arndyvdyobgtlpeh4rho7pywpi 158 10 further further RB work_arndyvdyobgtlpeh4rho7pywpi 158 11 metabolized metabolize VBN work_arndyvdyobgtlpeh4rho7pywpi 158 12 there there RB work_arndyvdyobgtlpeh4rho7pywpi 158 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 158 14 Gold- Gold- NNP work_arndyvdyobgtlpeh4rho7pywpi 158 15 berg berg NNP work_arndyvdyobgtlpeh4rho7pywpi 158 16 and and CC work_arndyvdyobgtlpeh4rho7pywpi 158 17 Chang Chang NNP work_arndyvdyobgtlpeh4rho7pywpi 158 18 1978 1978 CD work_arndyvdyobgtlpeh4rho7pywpi 158 19 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 158 20 or or CC work_arndyvdyobgtlpeh4rho7pywpi 158 21 transported transport VBN work_arndyvdyobgtlpeh4rho7pywpi 158 22 to to IN work_arndyvdyobgtlpeh4rho7pywpi 158 23 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 158 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 158 25 kidney kidney NN work_arndyvdyobgtlpeh4rho7pywpi 158 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 158 27 and and CC work_arndyvdyobgtlpeh4rho7pywpi 158 28 heart heart NN work_arndyvdyobgtlpeh4rho7pywpi 158 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 158 30 where where WRB work_arndyvdyobgtlpeh4rho7pywpi 158 31 they -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 158 32 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 158 33 oxidized oxidize VBN work_arndyvdyobgtlpeh4rho7pywpi 158 34 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 158 35 Chuang Chuang NNP work_arndyvdyobgtlpeh4rho7pywpi 158 36 and and CC work_arndyvdyobgtlpeh4rho7pywpi 158 37 Shih Shih NNP work_arndyvdyobgtlpeh4rho7pywpi 158 38 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 158 39 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 158 40 . . . work_arndyvdyobgtlpeh4rho7pywpi 159 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 159 2 the the DT work_arndyvdyobgtlpeh4rho7pywpi 159 3 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 159 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 159 5 a a DT work_arndyvdyobgtlpeh4rho7pywpi 159 6 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 159 7 isocaproic isocaproic JJ work_arndyvdyobgtlpeh4rho7pywpi 159 8 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 159 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 159 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 159 11 product product NN work_arndyvdyobgtlpeh4rho7pywpi 159 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 159 13 leucine leucine JJ work_arndyvdyobgtlpeh4rho7pywpi 159 14 transamination transamination NN work_arndyvdyobgtlpeh4rho7pywpi 159 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 159 16 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 159 17 further far RBR work_arndyvdyobgtlpeh4rho7pywpi 159 18 metabolized metabolize VBN work_arndyvdyobgtlpeh4rho7pywpi 159 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 159 20 via via IN work_arndyvdyobgtlpeh4rho7pywpi 159 21 3- 3- JJ work_arndyvdyobgtlpeh4rho7pywpi 159 22 methycrotonyl methycrotonyl NN work_arndyvdyobgtlpeh4rho7pywpi 159 23 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 159 24 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 159 25 and and CC work_arndyvdyobgtlpeh4rho7pywpi 159 26 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 159 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 159 28 to to IN work_arndyvdyobgtlpeh4rho7pywpi 159 29 acetyl acetyl NNP work_arndyvdyobgtlpeh4rho7pywpi 159 30 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 159 31 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 159 32 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 159 33 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 159 34 . . . work_arndyvdyobgtlpeh4rho7pywpi 160 1 3a 3a LS work_arndyvdyobgtlpeh4rho7pywpi 160 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 160 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 160 4 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 160 5 can can MD work_arndyvdyobgtlpeh4rho7pywpi 160 6 serve serve VB work_arndyvdyobgtlpeh4rho7pywpi 160 7 as as IN work_arndyvdyobgtlpeh4rho7pywpi 160 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 160 9 precursor precursor NN work_arndyvdyobgtlpeh4rho7pywpi 160 10 for for IN work_arndyvdyobgtlpeh4rho7pywpi 160 11 ketone ketone JJ work_arndyvdyobgtlpeh4rho7pywpi 160 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 160 13 body body NN work_arndyvdyobgtlpeh4rho7pywpi 160 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 160 15 is- is- XX work_arndyvdyobgtlpeh4rho7pywpi 160 16 oprenoid oprenoid JJ work_arndyvdyobgtlpeh4rho7pywpi 160 17 biosynthesis biosynthesis NN work_arndyvdyobgtlpeh4rho7pywpi 160 18 . . . work_arndyvdyobgtlpeh4rho7pywpi 161 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 161 2 the the DT work_arndyvdyobgtlpeh4rho7pywpi 161 3 muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 161 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 161 5 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 161 6 can can MD work_arndyvdyobgtlpeh4rho7pywpi 161 7 be be VB work_arndyvdyobgtlpeh4rho7pywpi 161 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 161 9 source source NN work_arndyvdyobgtlpeh4rho7pywpi 161 10 of of IN work_arndyvdyobgtlpeh4rho7pywpi 161 11 energy energy NN work_arndyvdyobgtlpeh4rho7pywpi 161 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 161 13 via via IN work_arndyvdyobgtlpeh4rho7pywpi 161 14 full full JJ work_arndyvdyobgtlpeh4rho7pywpi 161 15 oxidation oxidation NN work_arndyvdyobgtlpeh4rho7pywpi 161 16 to to IN work_arndyvdyobgtlpeh4rho7pywpi 161 17 CO2 CO2 NNP work_arndyvdyobgtlpeh4rho7pywpi 161 18 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 161 19 Goldberg Goldberg NNP work_arndyvdyobgtlpeh4rho7pywpi 161 20 and and CC work_arndyvdyobgtlpeh4rho7pywpi 161 21 Chang Chang NNP work_arndyvdyobgtlpeh4rho7pywpi 161 22 1978 1978 CD work_arndyvdyobgtlpeh4rho7pywpi 161 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 161 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 162 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 162 2 agreement agreement NN work_arndyvdyobgtlpeh4rho7pywpi 162 3 with with IN work_arndyvdyobgtlpeh4rho7pywpi 162 4 both both CC work_arndyvdyobgtlpeh4rho7pywpi 162 5 the the DT work_arndyvdyobgtlpeh4rho7pywpi 162 6 predicted predict VBN work_arndyvdyobgtlpeh4rho7pywpi 162 7 involvement involvement NN work_arndyvdyobgtlpeh4rho7pywpi 162 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 162 9 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 162 10 in in IN work_arndyvdyobgtlpeh4rho7pywpi 162 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 162 12 oxidation oxidation NN work_arndyvdyobgtlpeh4rho7pywpi 162 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 162 14 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 162 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 162 16 these these DT work_arndyvdyobgtlpeh4rho7pywpi 162 17 tissues tissue NNS work_arndyvdyobgtlpeh4rho7pywpi 162 18 and and CC work_arndyvdyobgtlpeh4rho7pywpi 162 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 162 20 heteromeric heteromeric NN work_arndyvdyobgtlpeh4rho7pywpi 162 21 nature nature NN work_arndyvdyobgtlpeh4rho7pywpi 162 22 of of IN work_arndyvdyobgtlpeh4rho7pywpi 162 23 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 162 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 162 25 northern northern JJ work_arndyvdyobgtlpeh4rho7pywpi 162 26 blot blot NN work_arndyvdyobgtlpeh4rho7pywpi 162 27 hybridization hybridization NN work_arndyvdyobgtlpeh4rho7pywpi 162 28 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 162 29 that that IN work_arndyvdyobgtlpeh4rho7pywpi 162 30 the the DT work_arndyvdyobgtlpeh4rho7pywpi 162 31 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 162 32 and and CC work_arndyvdyobgtlpeh4rho7pywpi 162 33 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 162 34 transcripts transcript NNS work_arndyvdyobgtlpeh4rho7pywpi 162 35 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 162 36 coordinately coordinately RB work_arndyvdyobgtlpeh4rho7pywpi 162 37 expressed express VBN work_arndyvdyobgtlpeh4rho7pywpi 162 38 at at IN work_arndyvdyobgtlpeh4rho7pywpi 162 39 high high JJ work_arndyvdyobgtlpeh4rho7pywpi 162 40 levels level NNS work_arndyvdyobgtlpeh4rho7pywpi 162 41 in in IN work_arndyvdyobgtlpeh4rho7pywpi 162 42 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 162 43 , , , work_arndyvdyobgtlpeh4rho7pywpi 162 44 kidney kidney NN work_arndyvdyobgtlpeh4rho7pywpi 162 45 , , , work_arndyvdyobgtlpeh4rho7pywpi 162 46 heart heart NN work_arndyvdyobgtlpeh4rho7pywpi 162 47 , , , work_arndyvdyobgtlpeh4rho7pywpi 162 48 and and CC work_arndyvdyobgtlpeh4rho7pywpi 162 49 skeletal skeletal JJ work_arndyvdyobgtlpeh4rho7pywpi 162 50 muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 162 51 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 162 52 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 162 53 . . . work_arndyvdyobgtlpeh4rho7pywpi 163 1 3b 3b LS work_arndyvdyobgtlpeh4rho7pywpi 163 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 163 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 164 1 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 164 2 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 164 3 transcribed transcribe VBN work_arndyvdyobgtlpeh4rho7pywpi 164 4 as as IN work_arndyvdyobgtlpeh4rho7pywpi 164 5 a a DT work_arndyvdyobgtlpeh4rho7pywpi 164 6 single single JJ work_arndyvdyobgtlpeh4rho7pywpi 164 7 2.6-kb 2.6-kb CD work_arndyvdyobgtlpeh4rho7pywpi 164 8 message message NN work_arndyvdyobgtlpeh4rho7pywpi 164 9 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 164 10 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 164 11 gives give VBZ work_arndyvdyobgtlpeh4rho7pywpi 164 12 rise rise NN work_arndyvdyobgtlpeh4rho7pywpi 164 13 to to IN work_arndyvdyobgtlpeh4rho7pywpi 164 14 a a DT work_arndyvdyobgtlpeh4rho7pywpi 164 15 minor minor JJ work_arndyvdyobgtlpeh4rho7pywpi 164 16 2.4-kb 2.4-kb CD work_arndyvdyobgtlpeh4rho7pywpi 164 17 transcript transcript NN work_arndyvdyobgtlpeh4rho7pywpi 164 18 and and CC work_arndyvdyobgtlpeh4rho7pywpi 164 19 a a DT work_arndyvdyobgtlpeh4rho7pywpi 164 20 major major JJ work_arndyvdyobgtlpeh4rho7pywpi 164 21 4-kb 4-kb CD work_arndyvdyobgtlpeh4rho7pywpi 164 22 tran- tran- NN work_arndyvdyobgtlpeh4rho7pywpi 164 23 script script NN work_arndyvdyobgtlpeh4rho7pywpi 164 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 165 1 This this DT work_arndyvdyobgtlpeh4rho7pywpi 165 2 long long JJ work_arndyvdyobgtlpeh4rho7pywpi 165 3 transcript transcript NN work_arndyvdyobgtlpeh4rho7pywpi 165 4 almost almost RB work_arndyvdyobgtlpeh4rho7pywpi 165 5 certainly certainly RB work_arndyvdyobgtlpeh4rho7pywpi 165 6 results result VBZ work_arndyvdyobgtlpeh4rho7pywpi 165 7 from from IN work_arndyvdyobgtlpeh4rho7pywpi 165 8 further further JJ work_arndyvdyobgtlpeh4rho7pywpi 165 9 downstream downstream JJ work_arndyvdyobgtlpeh4rho7pywpi 165 10 polyadenylation polyadenylation NN work_arndyvdyobgtlpeh4rho7pywpi 165 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 165 12 exon exon NNP work_arndyvdyobgtlpeh4rho7pywpi 165 13 17 17 CD work_arndyvdyobgtlpeh4rho7pywpi 165 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 165 15 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 165 16 would would MD work_arndyvdyobgtlpeh4rho7pywpi 165 17 lead lead VB work_arndyvdyobgtlpeh4rho7pywpi 165 18 to to IN work_arndyvdyobgtlpeh4rho7pywpi 165 19 a a DT work_arndyvdyobgtlpeh4rho7pywpi 165 20 long long JJ work_arndyvdyobgtlpeh4rho7pywpi 165 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 165 22 ∼1.5 ∼1.5 NNP work_arndyvdyobgtlpeh4rho7pywpi 165 23 kb kb NNP work_arndyvdyobgtlpeh4rho7pywpi 165 24 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 165 25 3′ 3′ CD work_arndyvdyobgtlpeh4rho7pywpi 165 26 UTR UTR NNP work_arndyvdyobgtlpeh4rho7pywpi 165 27 . . . work_arndyvdyobgtlpeh4rho7pywpi 166 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 166 2 presence presence NN work_arndyvdyobgtlpeh4rho7pywpi 166 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 166 4 this this DT work_arndyvdyobgtlpeh4rho7pywpi 166 5 long long JJ work_arndyvdyobgtlpeh4rho7pywpi 166 6 3′ 3′ CD work_arndyvdyobgtlpeh4rho7pywpi 166 7 UTR UTR NNP work_arndyvdyobgtlpeh4rho7pywpi 166 8 within within IN work_arndyvdyobgtlpeh4rho7pywpi 166 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 166 10 human human NN work_arndyvdyobgtlpeh4rho7pywpi 166 11 transcriptome transcriptome NN work_arndyvdyobgtlpeh4rho7pywpi 166 12 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 166 13 confirmed confirm VBN work_arndyvdyobgtlpeh4rho7pywpi 166 14 by by IN work_arndyvdyobgtlpeh4rho7pywpi 166 15 both both DT work_arndyvdyobgtlpeh4rho7pywpi 166 16 RT RT NNP work_arndyvdyobgtlpeh4rho7pywpi 166 17 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 166 18 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 166 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 166 20 table table NN work_arndyvdyobgtlpeh4rho7pywpi 166 21 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 166 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 166 23 and and CC work_arndyvdyobgtlpeh4rho7pywpi 166 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 166 25 identifi- identifi- NN work_arndyvdyobgtlpeh4rho7pywpi 166 26 340 340 CD work_arndyvdyobgtlpeh4rho7pywpi 166 27 Am am NN work_arndyvdyobgtlpeh4rho7pywpi 166 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 167 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 167 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 167 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 168 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 168 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 169 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 169 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 169 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 169 4 Figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 169 5 2 2 CD work_arndyvdyobgtlpeh4rho7pywpi 169 6 Chromosomal chromosomal JJ work_arndyvdyobgtlpeh4rho7pywpi 169 7 localization localization NN work_arndyvdyobgtlpeh4rho7pywpi 169 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 169 9 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 169 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 169 11 A a NN work_arndyvdyobgtlpeh4rho7pywpi 169 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 169 13 and and CC work_arndyvdyobgtlpeh4rho7pywpi 169 14 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 169 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 169 16 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 169 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 169 18 . . . work_arndyvdyobgtlpeh4rho7pywpi 170 1 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 170 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 170 3 mapping mapping NN work_arndyvdyobgtlpeh4rho7pywpi 170 4 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 170 5 with with IN work_arndyvdyobgtlpeh4rho7pywpi 170 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 170 7 GB4 GB4 NNP work_arndyvdyobgtlpeh4rho7pywpi 170 8 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 170 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 170 10 for for IN work_arndyvdyobgtlpeh4rho7pywpi 170 11 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 170 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 170 13 and and CC work_arndyvdyobgtlpeh4rho7pywpi 170 14 with with IN work_arndyvdyobgtlpeh4rho7pywpi 170 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 170 16 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 170 17 and and CC work_arndyvdyobgtlpeh4rho7pywpi 170 18 GB4 GB4 NNP work_arndyvdyobgtlpeh4rho7pywpi 170 19 panels panel NNS work_arndyvdyobgtlpeh4rho7pywpi 170 20 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 170 21 for for IN work_arndyvdyobgtlpeh4rho7pywpi 170 22 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 170 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 170 24 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 170 25 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 170 26 . . . work_arndyvdyobgtlpeh4rho7pywpi 171 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 171 2 nearly nearly RB work_arndyvdyobgtlpeh4rho7pywpi 171 3 telomeric telomeric JJ work_arndyvdyobgtlpeh4rho7pywpi 171 4 chromosomal chromosomal JJ work_arndyvdyobgtlpeh4rho7pywpi 171 5 localization localization NN work_arndyvdyobgtlpeh4rho7pywpi 171 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 171 7 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 171 8 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 171 9 confirmed confirm VBN work_arndyvdyobgtlpeh4rho7pywpi 171 10 by by IN work_arndyvdyobgtlpeh4rho7pywpi 171 11 FISH FISH NNS work_arndyvdyobgtlpeh4rho7pywpi 171 12 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 171 13 see see VB work_arndyvdyobgtlpeh4rho7pywpi 171 14 insets inset NNS work_arndyvdyobgtlpeh4rho7pywpi 171 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 171 16 individual individual JJ work_arndyvdyobgtlpeh4rho7pywpi 171 17 chromosomes chromosome NNS work_arndyvdyobgtlpeh4rho7pywpi 171 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 171 19 in in IN work_arndyvdyobgtlpeh4rho7pywpi 171 20 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 171 21 A a NN work_arndyvdyobgtlpeh4rho7pywpi 171 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 171 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 172 1 cation cation NN work_arndyvdyobgtlpeh4rho7pywpi 172 2 of of IN work_arndyvdyobgtlpeh4rho7pywpi 172 3 EST EST NNP work_arndyvdyobgtlpeh4rho7pywpi 172 4 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 172 5 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 172 6 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 172 7 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 172 8 numbers number NNS work_arndyvdyobgtlpeh4rho7pywpi 172 9 AW439494 aw439494 NN work_arndyvdyobgtlpeh4rho7pywpi 172 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 172 11 AI869038 ai869038 NN work_arndyvdyobgtlpeh4rho7pywpi 172 12 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 172 13 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 172 14 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 172 15 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 172 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 172 17 con- con- NN work_arndyvdyobgtlpeh4rho7pywpi 172 18 taining taine VBG work_arndyvdyobgtlpeh4rho7pywpi 172 19 this this DT work_arndyvdyobgtlpeh4rho7pywpi 172 20 region region NN work_arndyvdyobgtlpeh4rho7pywpi 172 21 . . . work_arndyvdyobgtlpeh4rho7pywpi 173 1 Mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 173 2 in in IN work_arndyvdyobgtlpeh4rho7pywpi 173 3 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 173 4 or or CC work_arndyvdyobgtlpeh4rho7pywpi 173 5 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 173 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 173 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 173 8 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 173 9 with with IN work_arndyvdyobgtlpeh4rho7pywpi 173 10 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 173 11 To to TO work_arndyvdyobgtlpeh4rho7pywpi 173 12 confirm confirm VB work_arndyvdyobgtlpeh4rho7pywpi 173 13 the the DT work_arndyvdyobgtlpeh4rho7pywpi 173 14 involvement involvement NN work_arndyvdyobgtlpeh4rho7pywpi 173 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 173 16 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 173 17 and and CC work_arndyvdyobgtlpeh4rho7pywpi 173 18 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 173 19 in in IN work_arndyvdyobgtlpeh4rho7pywpi 173 20 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 173 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 173 22 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 173 23 screened screen VBD work_arndyvdyobgtlpeh4rho7pywpi 173 24 for for IN work_arndyvdyobgtlpeh4rho7pywpi 173 25 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 173 26 in in IN work_arndyvdyobgtlpeh4rho7pywpi 173 27 the the DT work_arndyvdyobgtlpeh4rho7pywpi 173 28 cloned clone VBN work_arndyvdyobgtlpeh4rho7pywpi 173 29 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 173 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 173 31 seven seven CD work_arndyvdyobgtlpeh4rho7pywpi 173 32 probands proband NNS work_arndyvdyobgtlpeh4rho7pywpi 173 33 . . . work_arndyvdyobgtlpeh4rho7pywpi 174 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 174 2 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 174 3 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 174 4 one one CD work_arndyvdyobgtlpeh4rho7pywpi 174 5 from from IN work_arndyvdyobgtlpeh4rho7pywpi 174 6 Argentina Argentina NNP work_arndyvdyobgtlpeh4rho7pywpi 174 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 174 8 one one CD work_arndyvdyobgtlpeh4rho7pywpi 174 9 from from IN work_arndyvdyobgtlpeh4rho7pywpi 174 10 Spain Spain NNP work_arndyvdyobgtlpeh4rho7pywpi 174 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 174 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 174 13 five five CD work_arndyvdyobgtlpeh4rho7pywpi 174 14 from from IN work_arndyvdyobgtlpeh4rho7pywpi 174 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 174 16 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 174 17 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 174 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 174 19 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 174 20 un- un- RB work_arndyvdyobgtlpeh4rho7pywpi 174 21 related related JJ work_arndyvdyobgtlpeh4rho7pywpi 174 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 174 23 although although IN work_arndyvdyobgtlpeh4rho7pywpi 174 24 two two CD work_arndyvdyobgtlpeh4rho7pywpi 174 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 174 26 them -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 174 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 174 28 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 174 29 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 174 30 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 174 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 175 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 175 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 175 3 be- be- XX work_arndyvdyobgtlpeh4rho7pywpi 175 4 long long RB work_arndyvdyobgtlpeh4rho7pywpi 175 5 to to IN work_arndyvdyobgtlpeh4rho7pywpi 175 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 175 7 Amish amish JJ work_arndyvdyobgtlpeh4rho7pywpi 175 8 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 175 9 Mennonite Mennonite NNP work_arndyvdyobgtlpeh4rho7pywpi 175 10 population population NN work_arndyvdyobgtlpeh4rho7pywpi 175 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 175 12 Lancaster Lancaster NNP work_arndyvdyobgtlpeh4rho7pywpi 175 13 County County NNP work_arndyvdyobgtlpeh4rho7pywpi 175 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 175 15 Pennsylvania Pennsylvania NNP work_arndyvdyobgtlpeh4rho7pywpi 175 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 176 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 176 2 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 176 3 either either CC work_arndyvdyobgtlpeh4rho7pywpi 176 4 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 176 5 el- el- NNP work_arndyvdyobgtlpeh4rho7pywpi 176 6 evated evated JJ work_arndyvdyobgtlpeh4rho7pywpi 176 7 excretion excretion NN work_arndyvdyobgtlpeh4rho7pywpi 176 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 176 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 176 10 diagnostic diagnostic JJ work_arndyvdyobgtlpeh4rho7pywpi 176 11 compounds compound NNS work_arndyvdyobgtlpeh4rho7pywpi 176 12 3-meth- 3-meth- NNP work_arndyvdyobgtlpeh4rho7pywpi 176 13 ylcrotonylglycine ylcrotonylglycine CD work_arndyvdyobgtlpeh4rho7pywpi 176 14 or or CC work_arndyvdyobgtlpeh4rho7pywpi 176 15 3-hydroxyisovaleric 3-hydroxyisovaleric CD work_arndyvdyobgtlpeh4rho7pywpi 176 16 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 176 17 or or CC work_arndyvdyobgtlpeh4rho7pywpi 176 18 came come VBD work_arndyvdyobgtlpeh4rho7pywpi 176 19 to to IN work_arndyvdyobgtlpeh4rho7pywpi 176 20 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 176 21 attention attention NN work_arndyvdyobgtlpeh4rho7pywpi 176 22 because because IN work_arndyvdyobgtlpeh4rho7pywpi 176 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 176 24 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 176 25 abnormally abnormally RB work_arndyvdyobgtlpeh4rho7pywpi 176 26 increased increase VBN work_arndyvdyobgtlpeh4rho7pywpi 176 27 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 176 28 levels level NNS work_arndyvdyobgtlpeh4rho7pywpi 176 29 of of IN work_arndyvdyobgtlpeh4rho7pywpi 176 30 C5-OH c5-oh ADD work_arndyvdyobgtlpeh4rho7pywpi 176 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 177 1 All all DT work_arndyvdyobgtlpeh4rho7pywpi 177 2 of of IN work_arndyvdyobgtlpeh4rho7pywpi 177 3 them -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 177 4 had have VBD work_arndyvdyobgtlpeh4rho7pywpi 177 5 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 177 6 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 177 7 to to TO work_arndyvdyobgtlpeh4rho7pywpi 177 8 be be VB work_arndyvdyobgtlpeh4rho7pywpi 177 9 deficient deficient JJ work_arndyvdyobgtlpeh4rho7pywpi 177 10 for for IN work_arndyvdyobgtlpeh4rho7pywpi 177 11 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 177 12 but but CC work_arndyvdyobgtlpeh4rho7pywpi 177 13 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 177 14 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 177 15 for for IN work_arndyvdyobgtlpeh4rho7pywpi 177 16 at at RB work_arndyvdyobgtlpeh4rho7pywpi 177 17 least least RBS work_arndyvdyobgtlpeh4rho7pywpi 177 18 one one CD work_arndyvdyobgtlpeh4rho7pywpi 177 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 177 20 the the DT work_arndyvdyobgtlpeh4rho7pywpi 177 21 other other JJ work_arndyvdyobgtlpeh4rho7pywpi 177 22 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 177 23 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 177 24 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 177 25 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 177 26 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 177 27 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 177 28 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 177 29 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 177 30 . . . work_arndyvdyobgtlpeh4rho7pywpi 178 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 178 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 178 3 and and CC work_arndyvdyobgtlpeh4rho7pywpi 178 4 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 178 5 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 178 6 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 178 7 3H]-biotin 3h]-biotin NN work_arndyvdyobgtlpeh4rho7pywpi 178 8 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 178 9 of of IN work_arndyvdyobgtlpeh4rho7pywpi 178 10 PC pc NN work_arndyvdyobgtlpeh4rho7pywpi 178 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 178 12 PCCa PCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 178 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 178 14 see see VB work_arndyvdyobgtlpeh4rho7pywpi 178 15 below below RB work_arndyvdyobgtlpeh4rho7pywpi 178 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 178 17 . . . work_arndyvdyobgtlpeh4rho7pywpi 179 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 179 2 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 179 3 rule rule VBP work_arndyvdyobgtlpeh4rho7pywpi 179 4 out out RP work_arndyvdyobgtlpeh4rho7pywpi 179 5 a a DT work_arndyvdyobgtlpeh4rho7pywpi 179 6 multiple- multiple- NN work_arndyvdyobgtlpeh4rho7pywpi 179 7 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 179 8 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 179 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 179 10 i.e. i.e. FW work_arndyvdyobgtlpeh4rho7pywpi 179 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 179 12 a a DT work_arndyvdyobgtlpeh4rho7pywpi 179 13 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 179 14 of of IN work_arndyvdyobgtlpeh4rho7pywpi 179 15 all all DT work_arndyvdyobgtlpeh4rho7pywpi 179 16 four four CD work_arndyvdyobgtlpeh4rho7pywpi 179 17 bi- bi- JJ work_arndyvdyobgtlpeh4rho7pywpi 179 18 otin otin NN work_arndyvdyobgtlpeh4rho7pywpi 179 19 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 179 20 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 179 21 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 179 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 179 23 resulting result VBG work_arndyvdyobgtlpeh4rho7pywpi 179 24 from from IN work_arndyvdyobgtlpeh4rho7pywpi 179 25 defects defect NNS work_arndyvdyobgtlpeh4rho7pywpi 179 26 ei- ei- XX work_arndyvdyobgtlpeh4rho7pywpi 179 27 ther ther NNP work_arndyvdyobgtlpeh4rho7pywpi 179 28 in in IN work_arndyvdyobgtlpeh4rho7pywpi 179 29 the the DT work_arndyvdyobgtlpeh4rho7pywpi 179 30 insertion insertion NN work_arndyvdyobgtlpeh4rho7pywpi 179 31 of of IN work_arndyvdyobgtlpeh4rho7pywpi 179 32 the the DT work_arndyvdyobgtlpeh4rho7pywpi 179 33 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 179 34 cofactor cofactor NN work_arndyvdyobgtlpeh4rho7pywpi 179 35 into into IN work_arndyvdyobgtlpeh4rho7pywpi 179 36 the the DT work_arndyvdyobgtlpeh4rho7pywpi 179 37 apoenzymes apoenzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 179 38 or or CC work_arndyvdyobgtlpeh4rho7pywpi 179 39 in in IN work_arndyvdyobgtlpeh4rho7pywpi 179 40 the the DT work_arndyvdyobgtlpeh4rho7pywpi 179 41 recycling recycling NN work_arndyvdyobgtlpeh4rho7pywpi 179 42 of of IN work_arndyvdyobgtlpeh4rho7pywpi 179 43 the the DT work_arndyvdyobgtlpeh4rho7pywpi 179 44 cofactor cofactor NN work_arndyvdyobgtlpeh4rho7pywpi 179 45 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 179 46 Wolf Wolf NNP work_arndyvdyobgtlpeh4rho7pywpi 179 47 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 179 48 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 179 49 . . . work_arndyvdyobgtlpeh4rho7pywpi 180 1 Polyethylene Polyethylene NNP work_arndyvdyobgtlpeh4rho7pywpi 180 2 glycol glycol NNP work_arndyvdyobgtlpeh4rho7pywpi 180 3 – – : work_arndyvdyobgtlpeh4rho7pywpi 180 4 mediated mediate VBN work_arndyvdyobgtlpeh4rho7pywpi 180 5 heterokaryosis heterokaryosis NN work_arndyvdyobgtlpeh4rho7pywpi 180 6 between between IN work_arndyvdyobgtlpeh4rho7pywpi 180 7 fibroblast fibroblast JJ work_arndyvdyobgtlpeh4rho7pywpi 180 8 cell cell NN work_arndyvdyobgtlpeh4rho7pywpi 180 9 lines line NNS work_arndyvdyobgtlpeh4rho7pywpi 180 10 from from IN work_arndyvdyobgtlpeh4rho7pywpi 180 11 five five CD work_arndyvdyobgtlpeh4rho7pywpi 180 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 180 13 these these DT work_arndyvdyobgtlpeh4rho7pywpi 180 14 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 180 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 180 16 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 180 17 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 180 18 not not RB work_arndyvdyobgtlpeh4rho7pywpi 180 19 available available JJ work_arndyvdyobgtlpeh4rho7pywpi 180 20 for for IN work_arndyvdyobgtlpeh4rho7pywpi 180 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 180 22 remaining remain VBG work_arndyvdyobgtlpeh4rho7pywpi 180 23 two two CD work_arndyvdyobgtlpeh4rho7pywpi 180 24 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 180 25 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 180 26 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 180 27 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 180 28 to to TO work_arndyvdyobgtlpeh4rho7pywpi 180 29 classify classify VB work_arndyvdyobgtlpeh4rho7pywpi 180 30 them -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 180 31 into into IN work_arndyvdyobgtlpeh4rho7pywpi 180 32 two two CD work_arndyvdyobgtlpeh4rho7pywpi 180 33 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 180 34 groups group NNS work_arndyvdyobgtlpeh4rho7pywpi 180 35 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 180 36 table table NN work_arndyvdyobgtlpeh4rho7pywpi 180 37 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 180 38 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 180 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 181 1 By by IN work_arndyvdyobgtlpeh4rho7pywpi 181 2 analogy analogy NN work_arndyvdyobgtlpeh4rho7pywpi 181 3 to to IN work_arndyvdyobgtlpeh4rho7pywpi 181 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 181 5 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 181 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 181 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 181 8 dicistronic dicistronic JJ work_arndyvdyobgtlpeh4rho7pywpi 181 9 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 181 10 PCC PCC NNP work_arndyvdyobgtlpeh4rho7pywpi 181 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 181 12 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 181 13 et et FW work_arndyvdyobgtlpeh4rho7pywpi 181 14 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 181 15 . . . work_arndyvdyobgtlpeh4rho7pywpi 182 1 1977 1977 CD work_arndyvdyobgtlpeh4rho7pywpi 182 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 182 3 Ugarte Ugarte NNP work_arndyvdyobgtlpeh4rho7pywpi 182 4 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 182 5 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 182 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 183 1 1999 1999 CD work_arndyvdyobgtlpeh4rho7pywpi 183 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 183 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 183 4 each each DT work_arndyvdyobgtlpeh4rho7pywpi 183 5 of of IN work_arndyvdyobgtlpeh4rho7pywpi 183 6 these these DT work_arndyvdyobgtlpeh4rho7pywpi 183 7 two two CD work_arndyvdyobgtlpeh4rho7pywpi 183 8 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 183 9 groups group NNS work_arndyvdyobgtlpeh4rho7pywpi 183 10 would would MD work_arndyvdyobgtlpeh4rho7pywpi 183 11 be be VB work_arndyvdyobgtlpeh4rho7pywpi 183 12 defined define VBN work_arndyvdyobgtlpeh4rho7pywpi 183 13 by by IN work_arndyvdyobgtlpeh4rho7pywpi 183 14 recessive recessive JJ work_arndyvdyobgtlpeh4rho7pywpi 183 15 loss loss NN work_arndyvdyobgtlpeh4rho7pywpi 183 16 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 183 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 183 18 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 183 19 function function NN work_arndyvdyobgtlpeh4rho7pywpi 183 20 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 183 21 in in IN work_arndyvdyobgtlpeh4rho7pywpi 183 22 one one CD work_arndyvdyobgtlpeh4rho7pywpi 183 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 183 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 183 25 two two CD work_arndyvdyobgtlpeh4rho7pywpi 183 26 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 183 27 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 183 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 183 29 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 183 30 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 183 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 184 1 Fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 184 2 from from IN work_arndyvdyobgtlpeh4rho7pywpi 184 3 the the DT work_arndyvdyobgtlpeh4rho7pywpi 184 4 Argentine argentine JJ work_arndyvdyobgtlpeh4rho7pywpi 184 5 patient patient NN work_arndyvdyobgtlpeh4rho7pywpi 184 6 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 184 7 arbitrarily arbitrarily RB work_arndyvdyobgtlpeh4rho7pywpi 184 8 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 184 9 as as IN work_arndyvdyobgtlpeh4rho7pywpi 184 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 184 11 reference reference NN work_arndyvdyobgtlpeh4rho7pywpi 184 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 185 1 Two two CD work_arndyvdyobgtlpeh4rho7pywpi 185 2 complementing complement VBG work_arndyvdyobgtlpeh4rho7pywpi 185 3 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 185 4 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 185 5 included include VBN work_arndyvdyobgtlpeh4rho7pywpi 185 6 within within IN work_arndyvdyobgtlpeh4rho7pywpi 185 7 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 185 8 group group NN work_arndyvdyobgtlpeh4rho7pywpi 185 9 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 185 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 185 11 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 185 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 185 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 185 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 185 15 two two CD work_arndyvdyobgtlpeh4rho7pywpi 185 16 non- non- NN work_arndyvdyobgtlpeh4rho7pywpi 185 17 complementing complementing NN work_arndyvdyobgtlpeh4rho7pywpi 185 18 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 185 19 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 185 20 included include VBN work_arndyvdyobgtlpeh4rho7pywpi 185 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 185 22 along along IN work_arndyvdyobgtlpeh4rho7pywpi 185 23 with with IN work_arndyvdyobgtlpeh4rho7pywpi 185 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 185 25 reference reference NN work_arndyvdyobgtlpeh4rho7pywpi 185 26 patient patient NN work_arndyvdyobgtlpeh4rho7pywpi 185 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 185 28 within within IN work_arndyvdyobgtlpeh4rho7pywpi 185 29 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 185 30 group group NN work_arndyvdyobgtlpeh4rho7pywpi 185 31 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 185 32 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 185 33 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 185 34 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 185 35 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 185 36 table table NN work_arndyvdyobgtlpeh4rho7pywpi 185 37 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 185 38 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 185 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 186 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 186 2 addition addition NN work_arndyvdyobgtlpeh4rho7pywpi 186 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 186 4 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 186 5 used use VBD work_arndyvdyobgtlpeh4rho7pywpi 186 6 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 186 7 3H]-biotin 3h]-biotin NN work_arndyvdyobgtlpeh4rho7pywpi 186 8 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 186 9 of of IN work_arndyvdyobgtlpeh4rho7pywpi 186 10 mitochondrial mitochondrial NN work_arndyvdyobgtlpeh4rho7pywpi 186 11 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 186 12 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 186 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 186 14 followed follow VBN work_arndyvdyobgtlpeh4rho7pywpi 186 15 by by IN work_arndyvdyobgtlpeh4rho7pywpi 186 16 SDS- SDS- NNP work_arndyvdyobgtlpeh4rho7pywpi 186 17 PAGE PAGE NNP work_arndyvdyobgtlpeh4rho7pywpi 186 18 and and CC work_arndyvdyobgtlpeh4rho7pywpi 186 19 autoradiography autoradiography NN work_arndyvdyobgtlpeh4rho7pywpi 186 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 186 21 to to TO work_arndyvdyobgtlpeh4rho7pywpi 186 22 resolve resolve VB work_arndyvdyobgtlpeh4rho7pywpi 186 23 PC pc NN work_arndyvdyobgtlpeh4rho7pywpi 186 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 186 25 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 186 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 186 27 and and CC work_arndyvdyobgtlpeh4rho7pywpi 186 28 PCCa PCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 186 29 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 186 30 Lamhonvah Lamhonvah NNP work_arndyvdyobgtlpeh4rho7pywpi 186 31 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 186 32 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 186 33 . . . work_arndyvdyobgtlpeh4rho7pywpi 187 1 1983 1983 CD work_arndyvdyobgtlpeh4rho7pywpi 187 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 187 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 188 1 Fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 188 2 of of IN work_arndyvdyobgtlpeh4rho7pywpi 188 3 all all DT work_arndyvdyobgtlpeh4rho7pywpi 188 4 of of IN work_arndyvdyobgtlpeh4rho7pywpi 188 5 these these DT work_arndyvdyobgtlpeh4rho7pywpi 188 6 five five CD work_arndyvdyobgtlpeh4rho7pywpi 188 7 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 188 8 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 188 9 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 188 10 PC pc NN work_arndyvdyobgtlpeh4rho7pywpi 188 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 188 12 PCCa PCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 188 13 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 188 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 188 15 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 188 16 not not RB work_arndyvdyobgtlpeh4rho7pywpi 188 17 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 188 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 188 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 189 1 However however RB work_arndyvdyobgtlpeh4rho7pywpi 189 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 189 3 whereas whereas IN work_arndyvdyobgtlpeh4rho7pywpi 189 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 189 5 three three CD work_arndyvdyobgtlpeh4rho7pywpi 189 6 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 189 7 pa- pa- NN work_arndyvdyobgtlpeh4rho7pywpi 189 8 tients tient NNS work_arndyvdyobgtlpeh4rho7pywpi 189 9 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 189 10 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 189 11 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 189 12 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 189 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 189 14 one one CD work_arndyvdyobgtlpeh4rho7pywpi 189 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 189 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 189 17 two two CD work_arndyvdyobgtlpeh4rho7pywpi 189 18 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 189 19 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 189 20 did do VBD work_arndyvdyobgtlpeh4rho7pywpi 189 21 not not RB work_arndyvdyobgtlpeh4rho7pywpi 189 22 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 189 23 fig fig VB work_arndyvdyobgtlpeh4rho7pywpi 189 24 . . . work_arndyvdyobgtlpeh4rho7pywpi 190 1 4 4 LS work_arndyvdyobgtlpeh4rho7pywpi 190 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 190 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 190 4 strongly strongly RB work_arndyvdyobgtlpeh4rho7pywpi 190 5 indicating indicate VBG work_arndyvdyobgtlpeh4rho7pywpi 190 6 that that IN work_arndyvdyobgtlpeh4rho7pywpi 190 7 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 190 8 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 190 9 defined define VBN work_arndyvdyobgtlpeh4rho7pywpi 190 10 by by IN work_arndyvdyobgtlpeh4rho7pywpi 190 11 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 190 12 in in IN work_arndyvdyobgtlpeh4rho7pywpi 190 13 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 190 14 . . . work_arndyvdyobgtlpeh4rho7pywpi 191 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 191 2 detected detect VBD work_arndyvdyobgtlpeh4rho7pywpi 191 3 two two CD work_arndyvdyobgtlpeh4rho7pywpi 191 4 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 191 5 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 191 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 191 7 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 191 8 in in IN work_arndyvdyobgtlpeh4rho7pywpi 191 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 191 10 two two CD work_arndyvdyobgtlpeh4rho7pywpi 191 11 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 191 12 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 191 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 191 14 fig fig VB work_arndyvdyobgtlpeh4rho7pywpi 191 15 . . . work_arndyvdyobgtlpeh4rho7pywpi 192 1 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 192 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 192 3 table table NN work_arndyvdyobgtlpeh4rho7pywpi 192 4 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 192 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 192 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 193 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 193 2 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 193 3 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 193 4 absent absent JJ work_arndyvdyobgtlpeh4rho7pywpi 193 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 193 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 193 7 sample sample NN work_arndyvdyobgtlpeh4rho7pywpi 193 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 193 9 100 100 CD work_arndyvdyobgtlpeh4rho7pywpi 193 10 control control NN work_arndyvdyobgtlpeh4rho7pywpi 193 11 chromosomes chromosome NNS work_arndyvdyobgtlpeh4rho7pywpi 193 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 194 1 M325R M325R NNP work_arndyvdyobgtlpeh4rho7pywpi 194 2 involves involve VBZ work_arndyvdyobgtlpeh4rho7pywpi 194 3 a a DT work_arndyvdyobgtlpeh4rho7pywpi 194 4 nonconservative nonconservative JJ work_arndyvdyobgtlpeh4rho7pywpi 194 5 substitution substitution NN work_arndyvdyobgtlpeh4rho7pywpi 194 6 leading lead VBG work_arndyvdyobgtlpeh4rho7pywpi 194 7 Gallardo Gallardo NNP work_arndyvdyobgtlpeh4rho7pywpi 194 8 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 194 9 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 194 10 . . . work_arndyvdyobgtlpeh4rho7pywpi 195 1 : : : work_arndyvdyobgtlpeh4rho7pywpi 195 2 3-Methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 195 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 195 4 CoA coa NN work_arndyvdyobgtlpeh4rho7pywpi 195 5 Carboxylase Carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 195 6 Deficiency Deficiency NNP work_arndyvdyobgtlpeh4rho7pywpi 195 7 341 341 CD work_arndyvdyobgtlpeh4rho7pywpi 195 8 Figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 195 9 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 195 10 A a DT work_arndyvdyobgtlpeh4rho7pywpi 195 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 195 12 Leucine Leucine NNP work_arndyvdyobgtlpeh4rho7pywpi 195 13 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 195 14 degradation degradation NN work_arndyvdyobgtlpeh4rho7pywpi 195 15 pathway pathway NN work_arndyvdyobgtlpeh4rho7pywpi 195 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 196 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 196 2 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 196 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 196 4 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 196 5 leads lead VBZ work_arndyvdyobgtlpeh4rho7pywpi 196 6 to to IN work_arndyvdyobgtlpeh4rho7pywpi 196 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 196 8 accumulation accumulation NN work_arndyvdyobgtlpeh4rho7pywpi 196 9 of of IN work_arndyvdyobgtlpeh4rho7pywpi 196 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 196 11 upstream upstream NNP work_arndyvdyobgtlpeh4rho7pywpi 196 12 compounds compound NNS work_arndyvdyobgtlpeh4rho7pywpi 196 13 isovaleryl isovaleryl NNP work_arndyvdyobgtlpeh4rho7pywpi 196 14 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 196 15 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 196 16 and and CC work_arndyvdyobgtlpeh4rho7pywpi 196 17 methylcrotonyl methylcrotonyl NNP work_arndyvdyobgtlpeh4rho7pywpi 196 18 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 196 19 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 196 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 196 21 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 196 22 lead lead VBP work_arndyvdyobgtlpeh4rho7pywpi 196 23 to to IN work_arndyvdyobgtlpeh4rho7pywpi 196 24 3-hydroxyisovaleric 3-hydroxyisovaleric CD work_arndyvdyobgtlpeh4rho7pywpi 196 25 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 196 26 3-HIVA 3-HIVA NNP work_arndyvdyobgtlpeh4rho7pywpi 196 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 196 28 and and CC work_arndyvdyobgtlpeh4rho7pywpi 196 29 3-methylcrotonylglycine 3-methylcrotonylglycine CD work_arndyvdyobgtlpeh4rho7pywpi 196 30 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 196 31 3-MC 3-mc CD work_arndyvdyobgtlpeh4rho7pywpi 196 32 - - : work_arndyvdyobgtlpeh4rho7pywpi 196 33 Gly gly NN work_arndyvdyobgtlpeh4rho7pywpi 196 34 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 196 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 196 36 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 196 37 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 196 38 biochemical biochemical JJ work_arndyvdyobgtlpeh4rho7pywpi 196 39 land- land- NN work_arndyvdyobgtlpeh4rho7pywpi 196 40 marks mark NNS work_arndyvdyobgtlpeh4rho7pywpi 196 41 of of IN work_arndyvdyobgtlpeh4rho7pywpi 196 42 the the DT work_arndyvdyobgtlpeh4rho7pywpi 196 43 isolated isolated JJ work_arndyvdyobgtlpeh4rho7pywpi 196 44 , , , work_arndyvdyobgtlpeh4rho7pywpi 196 45 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 196 46 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 196 47 insensitive insensitive JJ work_arndyvdyobgtlpeh4rho7pywpi 196 48 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 196 49 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 196 50 . . . work_arndyvdyobgtlpeh4rho7pywpi 197 1 B b UH work_arndyvdyobgtlpeh4rho7pywpi 197 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 197 3 Multitissue Multitissue NNP work_arndyvdyobgtlpeh4rho7pywpi 197 4 northern northern JJ work_arndyvdyobgtlpeh4rho7pywpi 197 5 blot blot NN work_arndyvdyobgtlpeh4rho7pywpi 197 6 hybridization hybridization NN work_arndyvdyobgtlpeh4rho7pywpi 197 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 197 8 showing show VBG work_arndyvdyobgtlpeh4rho7pywpi 197 9 coordinated coordinated JJ work_arndyvdyobgtlpeh4rho7pywpi 197 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 197 11 high high JJ work_arndyvdyobgtlpeh4rho7pywpi 197 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 197 13 level level NN work_arndyvdyobgtlpeh4rho7pywpi 197 14 expression expression NN work_arndyvdyobgtlpeh4rho7pywpi 197 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 197 16 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 197 17 and and CC work_arndyvdyobgtlpeh4rho7pywpi 197 18 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 197 19 in in IN work_arndyvdyobgtlpeh4rho7pywpi 197 20 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 197 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 197 22 kidney kidney NN work_arndyvdyobgtlpeh4rho7pywpi 197 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 197 24 heart heart NN work_arndyvdyobgtlpeh4rho7pywpi 197 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 197 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 197 27 skeletal skeletal JJ work_arndyvdyobgtlpeh4rho7pywpi 197 28 muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 197 29 . . . work_arndyvdyobgtlpeh4rho7pywpi 198 1 b b LS work_arndyvdyobgtlpeh4rho7pywpi 198 2 - - : work_arndyvdyobgtlpeh4rho7pywpi 198 3 Actin Actin NNP work_arndyvdyobgtlpeh4rho7pywpi 198 4 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 198 5 used use VBN work_arndyvdyobgtlpeh4rho7pywpi 198 6 as as IN work_arndyvdyobgtlpeh4rho7pywpi 198 7 a a DT work_arndyvdyobgtlpeh4rho7pywpi 198 8 loading loading NN work_arndyvdyobgtlpeh4rho7pywpi 198 9 control control NN work_arndyvdyobgtlpeh4rho7pywpi 198 10 . . . work_arndyvdyobgtlpeh4rho7pywpi 199 1 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 199 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 199 3 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 199 4 probes probe NNS work_arndyvdyobgtlpeh4rho7pywpi 199 5 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 199 6 ESTs ESTs NNP work_arndyvdyobgtlpeh4rho7pywpi 199 7 “ " `` work_arndyvdyobgtlpeh4rho7pywpi 199 8 AA605162 aa605162 NN work_arndyvdyobgtlpeh4rho7pywpi 199 9 ” " '' work_arndyvdyobgtlpeh4rho7pywpi 199 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 199 11 “ " `` work_arndyvdyobgtlpeh4rho7pywpi 199 12 AI949422 ai949422 FW work_arndyvdyobgtlpeh4rho7pywpi 199 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 199 14 ” " '' work_arndyvdyobgtlpeh4rho7pywpi 199 15 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 199 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 200 1 B b NN work_arndyvdyobgtlpeh4rho7pywpi 200 2 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 3 brain brain NN work_arndyvdyobgtlpeh4rho7pywpi 200 4 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 5 H h NN work_arndyvdyobgtlpeh4rho7pywpi 200 6 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 7 heart heart NN work_arndyvdyobgtlpeh4rho7pywpi 200 8 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 9 SM SM NNP work_arndyvdyobgtlpeh4rho7pywpi 200 10 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 11 skeletal skeletal JJ work_arndyvdyobgtlpeh4rho7pywpi 200 12 muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 200 13 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 14 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 200 15 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 16 colon colon NN work_arndyvdyobgtlpeh4rho7pywpi 200 17 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 18 T T NNP work_arndyvdyobgtlpeh4rho7pywpi 200 19 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 20 thymus thymus NN work_arndyvdyobgtlpeh4rho7pywpi 200 21 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 22 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 200 23 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 24 spleen spleen NN work_arndyvdyobgtlpeh4rho7pywpi 200 25 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 26 K K NNP work_arndyvdyobgtlpeh4rho7pywpi 200 27 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 28 kidney kidney NN work_arndyvdyobgtlpeh4rho7pywpi 200 29 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 30 Li Li NNP work_arndyvdyobgtlpeh4rho7pywpi 200 31 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 32 liver liver NN work_arndyvdyobgtlpeh4rho7pywpi 200 33 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 34 Si Si NNP work_arndyvdyobgtlpeh4rho7pywpi 200 35 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 36 small small JJ work_arndyvdyobgtlpeh4rho7pywpi 200 37 intestine intestine NN work_arndyvdyobgtlpeh4rho7pywpi 200 38 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 39 P p NN work_arndyvdyobgtlpeh4rho7pywpi 200 40 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 41 placenta placenta NN work_arndyvdyobgtlpeh4rho7pywpi 200 42 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 43 Lu Lu NNP work_arndyvdyobgtlpeh4rho7pywpi 200 44 p p NNP work_arndyvdyobgtlpeh4rho7pywpi 200 45 lung lung NN work_arndyvdyobgtlpeh4rho7pywpi 200 46 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 200 47 PBL PBL NNP work_arndyvdyobgtlpeh4rho7pywpi 200 48 p p NN work_arndyvdyobgtlpeh4rho7pywpi 200 49 peripheral peripheral JJ work_arndyvdyobgtlpeh4rho7pywpi 200 50 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 200 51 lymphocytes lymphocyte NNS work_arndyvdyobgtlpeh4rho7pywpi 200 52 . . . work_arndyvdyobgtlpeh4rho7pywpi 201 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 201 2 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 201 3 multiple multiple JJ work_arndyvdyobgtlpeh4rho7pywpi 201 4 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 201 5 tissue tissue NN work_arndyvdyobgtlpeh4rho7pywpi 201 6 northern northern JJ work_arndyvdyobgtlpeh4rho7pywpi 201 7 filter filter NN work_arndyvdyobgtlpeh4rho7pywpi 201 8 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 201 9 purchased purchase VBN work_arndyvdyobgtlpeh4rho7pywpi 201 10 from from IN work_arndyvdyobgtlpeh4rho7pywpi 201 11 Clontech Clontech NNP work_arndyvdyobgtlpeh4rho7pywpi 201 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 202 1 to to TO work_arndyvdyobgtlpeh4rho7pywpi 202 2 absence absence VB work_arndyvdyobgtlpeh4rho7pywpi 202 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 202 4 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 202 5 3H]-biotin 3h]-biotin NN work_arndyvdyobgtlpeh4rho7pywpi 202 6 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 202 7 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 202 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 202 9 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 202 10 . . . work_arndyvdyobgtlpeh4rho7pywpi 203 1 4 4 LS work_arndyvdyobgtlpeh4rho7pywpi 203 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 203 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 203 4 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 203 5 would would MD work_arndyvdyobgtlpeh4rho7pywpi 203 6 indicate indicate VB work_arndyvdyobgtlpeh4rho7pywpi 203 7 that that IN work_arndyvdyobgtlpeh4rho7pywpi 203 8 it -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 203 9 affects affect VBZ work_arndyvdyobgtlpeh4rho7pywpi 203 10 either either CC work_arndyvdyobgtlpeh4rho7pywpi 203 11 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 203 12 stability stability NN work_arndyvdyobgtlpeh4rho7pywpi 203 13 or or CC work_arndyvdyobgtlpeh4rho7pywpi 203 14 biotinylation biotinylation NN work_arndyvdyobgtlpeh4rho7pywpi 203 15 . . . work_arndyvdyobgtlpeh4rho7pywpi 204 1 R385S R385S NNP work_arndyvdyobgtlpeh4rho7pywpi 204 2 involves involve VBZ work_arndyvdyobgtlpeh4rho7pywpi 204 3 a a DT work_arndyvdyobgtlpeh4rho7pywpi 204 4 substitution substitution NN work_arndyvdyobgtlpeh4rho7pywpi 204 5 of of IN work_arndyvdyobgtlpeh4rho7pywpi 204 6 an an DT work_arndyvdyobgtlpeh4rho7pywpi 204 7 ar- ar- NN work_arndyvdyobgtlpeh4rho7pywpi 204 8 ginine ginine NN work_arndyvdyobgtlpeh4rho7pywpi 204 9 residue residue NN work_arndyvdyobgtlpeh4rho7pywpi 204 10 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 204 11 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 204 12 strictly strictly RB work_arndyvdyobgtlpeh4rho7pywpi 204 13 conserved conserve VBN work_arndyvdyobgtlpeh4rho7pywpi 204 14 among among IN work_arndyvdyobgtlpeh4rho7pywpi 204 15 humans human NNS work_arndyvdyobgtlpeh4rho7pywpi 204 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 204 17 plants plant NNS work_arndyvdyobgtlpeh4rho7pywpi 204 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 204 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 204 20 fungi fungus NNS work_arndyvdyobgtlpeh4rho7pywpi 204 21 . . . work_arndyvdyobgtlpeh4rho7pywpi 205 1 Human human JJ work_arndyvdyobgtlpeh4rho7pywpi 205 2 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 205 3 Arg385 Arg385 -LRB- work_arndyvdyobgtlpeh4rho7pywpi 205 4 corresponds correspond VBZ work_arndyvdyobgtlpeh4rho7pywpi 205 5 to to IN work_arndyvdyobgtlpeh4rho7pywpi 205 6 Arg338 arg338 CD work_arndyvdyobgtlpeh4rho7pywpi 205 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 205 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 205 9 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 205 10 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 205 11 carboxylating carboxylate VBG work_arndyvdyobgtlpeh4rho7pywpi 205 12 component component NN work_arndyvdyobgtlpeh4rho7pywpi 205 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 205 14 E. E. NNP work_arndyvdyobgtlpeh4rho7pywpi 205 15 coli coli NNP work_arndyvdyobgtlpeh4rho7pywpi 205 16 ACC ACC NNP work_arndyvdyobgtlpeh4rho7pywpi 205 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 205 18 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 205 19 appears appear VBZ work_arndyvdyobgtlpeh4rho7pywpi 205 20 to to TO work_arndyvdyobgtlpeh4rho7pywpi 205 21 form form VB work_arndyvdyobgtlpeh4rho7pywpi 205 22 part part NN work_arndyvdyobgtlpeh4rho7pywpi 205 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 205 24 a a DT work_arndyvdyobgtlpeh4rho7pywpi 205 25 positively positively RB work_arndyvdyobgtlpeh4rho7pywpi 205 26 charged charge VBN work_arndyvdyobgtlpeh4rho7pywpi 205 27 pocket pocket NN work_arndyvdyobgtlpeh4rho7pywpi 205 28 for for IN work_arndyvdyobgtlpeh4rho7pywpi 205 29 bicarbonate bicarbonate JJ work_arndyvdyobgtlpeh4rho7pywpi 205 30 binding binding NN work_arndyvdyobgtlpeh4rho7pywpi 205 31 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 205 32 Thoden Thoden NNP work_arndyvdyobgtlpeh4rho7pywpi 205 33 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 205 34 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 205 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 206 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 206 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 206 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 207 1 This this DT work_arndyvdyobgtlpeh4rho7pywpi 207 2 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 207 3 could could MD work_arndyvdyobgtlpeh4rho7pywpi 207 4 lead lead VB work_arndyvdyobgtlpeh4rho7pywpi 207 5 to to IN work_arndyvdyobgtlpeh4rho7pywpi 207 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 207 7 kinetic kinetic JJ work_arndyvdyobgtlpeh4rho7pywpi 207 8 defect defect NN work_arndyvdyobgtlpeh4rho7pywpi 207 9 with- with- NN work_arndyvdyobgtlpeh4rho7pywpi 207 10 out out RP work_arndyvdyobgtlpeh4rho7pywpi 207 11 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 207 12 destabilization destabilization NN work_arndyvdyobgtlpeh4rho7pywpi 207 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 207 14 as as IN work_arndyvdyobgtlpeh4rho7pywpi 207 15 indicated indicate VBN work_arndyvdyobgtlpeh4rho7pywpi 207 16 by by IN work_arndyvdyobgtlpeh4rho7pywpi 207 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 207 18 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 207 19 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 207 20 3H]-biotin 3h]-biotin NN work_arndyvdyobgtlpeh4rho7pywpi 207 21 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 207 22 of of IN work_arndyvdyobgtlpeh4rho7pywpi 207 23 mutant mutant JJ work_arndyvdyobgtlpeh4rho7pywpi 207 24 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 207 25 in in IN work_arndyvdyobgtlpeh4rho7pywpi 207 26 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 207 27 of of IN work_arndyvdyobgtlpeh4rho7pywpi 207 28 our -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 207 29 patient patient NN work_arndyvdyobgtlpeh4rho7pywpi 207 30 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 207 31 table table NN work_arndyvdyobgtlpeh4rho7pywpi 207 32 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 207 33 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 207 34 . . . work_arndyvdyobgtlpeh4rho7pywpi 208 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 208 2 addition addition NN work_arndyvdyobgtlpeh4rho7pywpi 208 3 to to IN work_arndyvdyobgtlpeh4rho7pywpi 208 4 these these DT work_arndyvdyobgtlpeh4rho7pywpi 208 5 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 208 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 208 7 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 208 8 detected detect VBD work_arndyvdyobgtlpeh4rho7pywpi 208 9 two two CD work_arndyvdyobgtlpeh4rho7pywpi 208 10 frequent frequent JJ work_arndyvdyobgtlpeh4rho7pywpi 208 11 polymorphisms polymorphism NNS work_arndyvdyobgtlpeh4rho7pywpi 208 12 in in IN work_arndyvdyobgtlpeh4rho7pywpi 208 13 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 208 14 — — : work_arndyvdyobgtlpeh4rho7pywpi 208 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 208 16 synonymous synonymous JJ work_arndyvdyobgtlpeh4rho7pywpi 208 17 point point NN work_arndyvdyobgtlpeh4rho7pywpi 208 18 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 208 19 c.396TrC c.396TrC NNP work_arndyvdyobgtlpeh4rho7pywpi 208 20 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 208 21 L132L L132L NNP work_arndyvdyobgtlpeh4rho7pywpi 208 22 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 208 23 and and CC work_arndyvdyobgtlpeh4rho7pywpi 208 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 208 25 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 208 26 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 208 27 c.1391ArC c.1391ArC NNP work_arndyvdyobgtlpeh4rho7pywpi 208 28 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 208 29 H464P H464P NNP work_arndyvdyobgtlpeh4rho7pywpi 208 30 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 208 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 209 1 Proline proline NN work_arndyvdyobgtlpeh4rho7pywpi 209 2 rather rather RB work_arndyvdyobgtlpeh4rho7pywpi 209 3 than than IN work_arndyvdyobgtlpeh4rho7pywpi 209 4 histidine histidine NNP work_arndyvdyobgtlpeh4rho7pywpi 209 5 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 209 6 present present JJ work_arndyvdyobgtlpeh4rho7pywpi 209 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 209 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 209 9 corresponding corresponding JJ work_arndyvdyobgtlpeh4rho7pywpi 209 10 position position NN work_arndyvdyobgtlpeh4rho7pywpi 209 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 209 12 Arabidopsis arabidopsis NN work_arndyvdyobgtlpeh4rho7pywpi 209 13 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 209 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 209 15 Song Song NNP work_arndyvdyobgtlpeh4rho7pywpi 209 16 et et FW work_arndyvdyobgtlpeh4rho7pywpi 209 17 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 209 18 . . . work_arndyvdyobgtlpeh4rho7pywpi 210 1 1994 1994 LS work_arndyvdyobgtlpeh4rho7pywpi 210 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 210 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 211 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 211 2 detected detect VBD work_arndyvdyobgtlpeh4rho7pywpi 211 3 three three CD work_arndyvdyobgtlpeh4rho7pywpi 211 4 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 211 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 211 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 211 7 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 211 8 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 211 9 in in IN work_arndyvdyobgtlpeh4rho7pywpi 211 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 211 11 three three CD work_arndyvdyobgtlpeh4rho7pywpi 211 12 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 211 13 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 211 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 211 15 fig fig VB work_arndyvdyobgtlpeh4rho7pywpi 211 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 212 1 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 212 2 and and CC work_arndyvdyobgtlpeh4rho7pywpi 212 3 table table NN work_arndyvdyobgtlpeh4rho7pywpi 212 4 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 212 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 212 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 213 1 An an DT work_arndyvdyobgtlpeh4rho7pywpi 213 2 additional additional JJ work_arndyvdyobgtlpeh4rho7pywpi 213 3 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 213 4 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 213 5 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 213 6 found find VBN work_arndyvdyobgtlpeh4rho7pywpi 213 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 213 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 213 9 two two CD work_arndyvdyobgtlpeh4rho7pywpi 213 10 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 213 11 who who WP work_arndyvdyobgtlpeh4rho7pywpi 213 12 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 213 13 not not RB work_arndyvdyobgtlpeh4rho7pywpi 213 14 included include VBN work_arndyvdyobgtlpeh4rho7pywpi 213 15 in in IN work_arndyvdyobgtlpeh4rho7pywpi 213 16 complementation complementation NN work_arndyvdyobgtlpeh4rho7pywpi 213 17 studies study NNS work_arndyvdyobgtlpeh4rho7pywpi 213 18 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 213 19 table table NN work_arndyvdyobgtlpeh4rho7pywpi 213 20 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 213 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 213 22 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 213 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 214 1 5 5 LS work_arndyvdyobgtlpeh4rho7pywpi 214 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 214 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 215 1 No no DT work_arndyvdyobgtlpeh4rho7pywpi 215 2 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 215 3 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 215 4 detected detect VBN work_arndyvdyobgtlpeh4rho7pywpi 215 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 215 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 215 7 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 215 8 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 215 9 of of IN work_arndyvdyobgtlpeh4rho7pywpi 215 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 215 11 latter latter JJ work_arndyvdyobgtlpeh4rho7pywpi 215 12 two two CD work_arndyvdyobgtlpeh4rho7pywpi 215 13 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 215 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 215 15 who who WP work_arndyvdyobgtlpeh4rho7pywpi 215 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 215 17 like like IN work_arndyvdyobgtlpeh4rho7pywpi 215 18 the the DT work_arndyvdyobgtlpeh4rho7pywpi 215 19 three three CD work_arndyvdyobgtlpeh4rho7pywpi 215 20 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 215 21 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 215 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 215 23 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 215 24 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 215 25 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 215 26 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 215 27 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 215 28 table table NN work_arndyvdyobgtlpeh4rho7pywpi 215 29 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 215 30 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 215 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 216 1 Two two CD work_arndyvdyobgtlpeh4rho7pywpi 216 2 of of IN work_arndyvdyobgtlpeh4rho7pywpi 216 3 these these DT work_arndyvdyobgtlpeh4rho7pywpi 216 4 four four CD work_arndyvdyobgtlpeh4rho7pywpi 216 5 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 216 6 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 216 7 almost almost RB work_arndyvdyobgtlpeh4rho7pywpi 216 8 certainly certainly RB work_arndyvdyobgtlpeh4rho7pywpi 216 9 repre- repre- XX work_arndyvdyobgtlpeh4rho7pywpi 216 10 sent send VBD work_arndyvdyobgtlpeh4rho7pywpi 216 11 null null JJ work_arndyvdyobgtlpeh4rho7pywpi 216 12 alleles allele NNS work_arndyvdyobgtlpeh4rho7pywpi 216 13 : : : work_arndyvdyobgtlpeh4rho7pywpi 216 14 D172fs D172fs NNP work_arndyvdyobgtlpeh4rho7pywpi 216 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 216 16 c.516insT c.516inst NN work_arndyvdyobgtlpeh4rho7pywpi 216 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 216 18 truncates truncate VBZ work_arndyvdyobgtlpeh4rho7pywpi 216 19 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 216 20 after after IN work_arndyvdyobgtlpeh4rho7pywpi 216 21 residue residue NN work_arndyvdyobgtlpeh4rho7pywpi 216 22 172 172 CD work_arndyvdyobgtlpeh4rho7pywpi 216 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 216 24 and and CC work_arndyvdyobgtlpeh4rho7pywpi 216 25 IVS3 IVS3 NNP work_arndyvdyobgtlpeh4rho7pywpi 216 26 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 216 27 5GrT 5grt CD work_arndyvdyobgtlpeh4rho7pywpi 216 28 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 216 29 a a DT work_arndyvdyobgtlpeh4rho7pywpi 216 30 splicing splicing NN work_arndyvdyobgtlpeh4rho7pywpi 216 31 mu- mu- JJ work_arndyvdyobgtlpeh4rho7pywpi 216 32 tation tation NN work_arndyvdyobgtlpeh4rho7pywpi 216 33 leading lead VBG work_arndyvdyobgtlpeh4rho7pywpi 216 34 to to IN work_arndyvdyobgtlpeh4rho7pywpi 216 35 skipping skipping NN work_arndyvdyobgtlpeh4rho7pywpi 216 36 of of IN work_arndyvdyobgtlpeh4rho7pywpi 216 37 exon exon NNP work_arndyvdyobgtlpeh4rho7pywpi 216 38 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 216 39 , , , work_arndyvdyobgtlpeh4rho7pywpi 216 40 frameshift frameshift NN work_arndyvdyobgtlpeh4rho7pywpi 216 41 , , , work_arndyvdyobgtlpeh4rho7pywpi 216 42 and and CC work_arndyvdyobgtlpeh4rho7pywpi 216 43 early early JJ work_arndyvdyobgtlpeh4rho7pywpi 216 44 truncation truncation NN work_arndyvdyobgtlpeh4rho7pywpi 216 45 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 216 46 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 216 47 . . . work_arndyvdyobgtlpeh4rho7pywpi 217 1 5 5 LS work_arndyvdyobgtlpeh4rho7pywpi 217 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 217 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 218 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 218 2 remaining remain VBG work_arndyvdyobgtlpeh4rho7pywpi 218 3 two two CD work_arndyvdyobgtlpeh4rho7pywpi 218 4 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 218 5 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 218 6 C167R C167R NNP work_arndyvdyobgtlpeh4rho7pywpi 218 7 and and CC work_arndyvdyobgtlpeh4rho7pywpi 218 8 A218 A218 NNP work_arndyvdyobgtlpeh4rho7pywpi 218 9 T T NNP work_arndyvdyobgtlpeh4rho7pywpi 218 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 218 11 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 218 12 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 218 13 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 218 14 involving involve VBG work_arndyvdyobgtlpeh4rho7pywpi 218 15 nonconservative nonconservative JJ work_arndyvdyobgtlpeh4rho7pywpi 218 16 substitutions substitution NNS work_arndyvdyobgtlpeh4rho7pywpi 218 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 218 18 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 218 19 residues residue NNS work_arndyvdyobgtlpeh4rho7pywpi 218 20 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 218 21 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 218 22 strictly strictly RB work_arndyvdyobgtlpeh4rho7pywpi 218 23 conserved conserve VBN work_arndyvdyobgtlpeh4rho7pywpi 218 24 among among IN work_arndyvdyobgtlpeh4rho7pywpi 218 25 humans human NNS work_arndyvdyobgtlpeh4rho7pywpi 218 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 218 27 fungi fungi NN work_arndyvdyobgtlpeh4rho7pywpi 218 28 , , , work_arndyvdyobgtlpeh4rho7pywpi 218 29 and and CC work_arndyvdyobgtlpeh4rho7pywpi 218 30 plants plant NNS work_arndyvdyobgtlpeh4rho7pywpi 218 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 219 1 Both both DT work_arndyvdyobgtlpeh4rho7pywpi 219 2 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 219 3 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 219 4 absent absent JJ work_arndyvdyobgtlpeh4rho7pywpi 219 5 from from IN work_arndyvdyobgtlpeh4rho7pywpi 219 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 219 7 sample sample NN work_arndyvdyobgtlpeh4rho7pywpi 219 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 219 9 100 100 CD work_arndyvdyobgtlpeh4rho7pywpi 219 10 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 219 11 chromosomes chromosome NNS work_arndyvdyobgtlpeh4rho7pywpi 219 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 220 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 220 2 Vivo Vivo NNP work_arndyvdyobgtlpeh4rho7pywpi 220 3 Involvement Involvement NNP work_arndyvdyobgtlpeh4rho7pywpi 220 4 of of IN work_arndyvdyobgtlpeh4rho7pywpi 220 5 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 220 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 220 7 Leucine Leucine NNP work_arndyvdyobgtlpeh4rho7pywpi 220 8 Catabolism Catabolism NNP work_arndyvdyobgtlpeh4rho7pywpi 220 9 The the DT work_arndyvdyobgtlpeh4rho7pywpi 220 10 haploid haploid NN work_arndyvdyobgtlpeh4rho7pywpi 220 11 fungus fungus NN work_arndyvdyobgtlpeh4rho7pywpi 220 12 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 220 13 nidulans nidulans NNPS work_arndyvdyobgtlpeh4rho7pywpi 220 14 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 220 15 able able JJ work_arndyvdyobgtlpeh4rho7pywpi 220 16 to to TO work_arndyvdyobgtlpeh4rho7pywpi 220 17 grow grow VB work_arndyvdyobgtlpeh4rho7pywpi 220 18 on on IN work_arndyvdyobgtlpeh4rho7pywpi 220 19 a a DT work_arndyvdyobgtlpeh4rho7pywpi 220 20 number number NN work_arndyvdyobgtlpeh4rho7pywpi 220 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 220 22 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 220 23 acids acid NNS work_arndyvdyobgtlpeh4rho7pywpi 220 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 220 25 as as IN work_arndyvdyobgtlpeh4rho7pywpi 220 26 the the DT work_arndyvdyobgtlpeh4rho7pywpi 220 27 sole sole JJ work_arndyvdyobgtlpeh4rho7pywpi 220 28 carbon carbon NN work_arndyvdyobgtlpeh4rho7pywpi 220 29 source source NN work_arndyvdyobgtlpeh4rho7pywpi 220 30 , , , work_arndyvdyobgtlpeh4rho7pywpi 220 31 using use VBG work_arndyvdyobgtlpeh4rho7pywpi 220 32 catabolic catabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 220 33 pathways pathway NNS work_arndyvdyobgtlpeh4rho7pywpi 220 34 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 220 35 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 220 36 very very RB work_arndyvdyobgtlpeh4rho7pywpi 220 37 similar similar JJ work_arndyvdyobgtlpeh4rho7pywpi 220 38 to to IN work_arndyvdyobgtlpeh4rho7pywpi 220 39 those those DT work_arndyvdyobgtlpeh4rho7pywpi 220 40 found find VBN work_arndyvdyobgtlpeh4rho7pywpi 220 41 in in IN work_arndyvdyobgtlpeh4rho7pywpi 220 42 humans human NNS work_arndyvdyobgtlpeh4rho7pywpi 220 43 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 220 44 Fernández Fernández NNP work_arndyvdyobgtlpeh4rho7pywpi 220 45 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 220 46 Cañón Cañón NNP work_arndyvdyobgtlpeh4rho7pywpi 220 47 and and CC work_arndyvdyobgtlpeh4rho7pywpi 220 48 Peñal- Peñal- NNP work_arndyvdyobgtlpeh4rho7pywpi 220 49 va va NNP work_arndyvdyobgtlpeh4rho7pywpi 220 50 1995a 1995a NNS work_arndyvdyobgtlpeh4rho7pywpi 220 51 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 220 52 . . . work_arndyvdyobgtlpeh4rho7pywpi 221 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 221 2 previous previous JJ work_arndyvdyobgtlpeh4rho7pywpi 221 3 studies study NNS work_arndyvdyobgtlpeh4rho7pywpi 221 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 221 5 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 221 6 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 221 7 exploited exploit VBN work_arndyvdyobgtlpeh4rho7pywpi 221 8 this this DT work_arndyvdyobgtlpeh4rho7pywpi 221 9 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 221 10 versatility versatility NN work_arndyvdyobgtlpeh4rho7pywpi 221 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 221 12 the the DT work_arndyvdyobgtlpeh4rho7pywpi 221 13 relatively relatively RB work_arndyvdyobgtlpeh4rho7pywpi 221 14 facile facile JJ work_arndyvdyobgtlpeh4rho7pywpi 221 15 genetic genetic JJ work_arndyvdyobgtlpeh4rho7pywpi 221 16 ma- ma- JJ work_arndyvdyobgtlpeh4rho7pywpi 221 17 nipulation nipulation NN work_arndyvdyobgtlpeh4rho7pywpi 221 18 of of IN work_arndyvdyobgtlpeh4rho7pywpi 221 19 this this DT work_arndyvdyobgtlpeh4rho7pywpi 221 20 lower low JJR work_arndyvdyobgtlpeh4rho7pywpi 221 21 eukaryote eukaryote NN work_arndyvdyobgtlpeh4rho7pywpi 221 22 in in IN work_arndyvdyobgtlpeh4rho7pywpi 221 23 order order NN work_arndyvdyobgtlpeh4rho7pywpi 221 24 to to TO work_arndyvdyobgtlpeh4rho7pywpi 221 25 charac- charac- VB work_arndyvdyobgtlpeh4rho7pywpi 221 26 terize terize VB work_arndyvdyobgtlpeh4rho7pywpi 221 27 the the DT work_arndyvdyobgtlpeh4rho7pywpi 221 28 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 221 29 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 221 30 of of IN work_arndyvdyobgtlpeh4rho7pywpi 221 31 phenylalanine phenylalanine NNP work_arndyvdyobgtlpeh4rho7pywpi 221 32 metabolism metabolism NNP work_arndyvdyobgtlpeh4rho7pywpi 221 33 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 221 34 Fernández Fernández NNP work_arndyvdyobgtlpeh4rho7pywpi 221 35 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 221 36 Cañón Cañón NNP work_arndyvdyobgtlpeh4rho7pywpi 221 37 and and CC work_arndyvdyobgtlpeh4rho7pywpi 221 38 Peñalva Peñalva NNP work_arndyvdyobgtlpeh4rho7pywpi 221 39 1995a 1995a NNS work_arndyvdyobgtlpeh4rho7pywpi 221 40 , , , work_arndyvdyobgtlpeh4rho7pywpi 221 41 1995b 1995b CD work_arndyvdyobgtlpeh4rho7pywpi 221 42 , , , work_arndyvdyobgtlpeh4rho7pywpi 221 43 1996 1996 CD work_arndyvdyobgtlpeh4rho7pywpi 221 44 , , , work_arndyvdyobgtlpeh4rho7pywpi 221 45 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 221 46 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 221 47 . . . work_arndyvdyobgtlpeh4rho7pywpi 222 1 Aspergillus aspergillus NN work_arndyvdyobgtlpeh4rho7pywpi 222 2 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 222 3 grows grow VBZ work_arndyvdyobgtlpeh4rho7pywpi 222 4 on on IN work_arndyvdyobgtlpeh4rho7pywpi 222 5 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 222 6 and and CC work_arndyvdyobgtlpeh4rho7pywpi 222 7 iso- iso- VB work_arndyvdyobgtlpeh4rho7pywpi 222 8 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 222 9 — — : work_arndyvdyobgtlpeh4rho7pywpi 222 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 222 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 222 12 to to IN work_arndyvdyobgtlpeh4rho7pywpi 222 13 a a DT work_arndyvdyobgtlpeh4rho7pywpi 222 14 lesser less JJR work_arndyvdyobgtlpeh4rho7pywpi 222 15 extent extent NN work_arndyvdyobgtlpeh4rho7pywpi 222 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 222 17 on on IN work_arndyvdyobgtlpeh4rho7pywpi 222 18 valine valine NN work_arndyvdyobgtlpeh4rho7pywpi 222 19 — — : work_arndyvdyobgtlpeh4rho7pywpi 222 20 as as IN work_arndyvdyobgtlpeh4rho7pywpi 222 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 222 22 sole sole JJ work_arndyvdyobgtlpeh4rho7pywpi 222 23 carbon carbon NN work_arndyvdyobgtlpeh4rho7pywpi 222 24 source source NN work_arndyvdyobgtlpeh4rho7pywpi 222 25 . . . work_arndyvdyobgtlpeh4rho7pywpi 223 1 dbEST dbEST NNP work_arndyvdyobgtlpeh4rho7pywpi 223 2 searches search NNS work_arndyvdyobgtlpeh4rho7pywpi 223 3 allowed allow VBD work_arndyvdyobgtlpeh4rho7pywpi 223 4 us -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 223 5 to to TO work_arndyvdyobgtlpeh4rho7pywpi 223 6 identify identify VB work_arndyvdyobgtlpeh4rho7pywpi 223 7 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 223 8 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 223 9 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 223 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 223 11 mccB mccb CD work_arndyvdyobgtlpeh4rho7pywpi 223 12 cDNAs cdna NNS work_arndyvdyobgtlpeh4rho7pywpi 223 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 223 14 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 223 15 en- en- RB work_arndyvdyobgtlpeh4rho7pywpi 223 16 code code NN work_arndyvdyobgtlpeh4rho7pywpi 223 17 fungal fungal NN work_arndyvdyobgtlpeh4rho7pywpi 223 18 MCCa MCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 223 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 223 20 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 223 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 223 22 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 223 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 224 1 Their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 224 2 ge- ge- VBN work_arndyvdyobgtlpeh4rho7pywpi 224 3 nomic nomic JJ work_arndyvdyobgtlpeh4rho7pywpi 224 4 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 224 5 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 224 6 that that IN work_arndyvdyobgtlpeh4rho7pywpi 224 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 224 8 together together RB work_arndyvdyobgtlpeh4rho7pywpi 224 9 with with IN work_arndyvdyobgtlpeh4rho7pywpi 224 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 224 11 342 342 CD work_arndyvdyobgtlpeh4rho7pywpi 224 12 Am Am NNP work_arndyvdyobgtlpeh4rho7pywpi 224 13 . . . work_arndyvdyobgtlpeh4rho7pywpi 225 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 225 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 225 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 226 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 226 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 227 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 227 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 227 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 227 4 Figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 227 5 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 227 6 Results result NNS work_arndyvdyobgtlpeh4rho7pywpi 227 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 227 8 in in IN work_arndyvdyobgtlpeh4rho7pywpi 227 9 vivo vivo NNP work_arndyvdyobgtlpeh4rho7pywpi 227 10 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 227 11 3H]-biotin 3h]-biotin NN work_arndyvdyobgtlpeh4rho7pywpi 227 12 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 227 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 227 14 mitochondrial mitochondrial NN work_arndyvdyobgtlpeh4rho7pywpi 227 15 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 227 16 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 227 17 containing contain VBG work_arndyvdyobgtlpeh4rho7pywpi 227 18 polypeptides polypeptide NNS work_arndyvdyobgtlpeh4rho7pywpi 227 19 PC pc NN work_arndyvdyobgtlpeh4rho7pywpi 227 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 227 21 PCCa PCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 227 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 227 23 and and CC work_arndyvdyobgtlpeh4rho7pywpi 227 24 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 227 25 . . . work_arndyvdyobgtlpeh4rho7pywpi 228 1 Cultured cultured JJ work_arndyvdyobgtlpeh4rho7pywpi 228 2 fi- fi- JJ work_arndyvdyobgtlpeh4rho7pywpi 228 3 broblasts broblast NNS work_arndyvdyobgtlpeh4rho7pywpi 228 4 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 228 5 relevant relevant JJ work_arndyvdyobgtlpeh4rho7pywpi 228 6 genotypes genotype NNS work_arndyvdyobgtlpeh4rho7pywpi 228 7 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 228 8 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 228 9 at at IN work_arndyvdyobgtlpeh4rho7pywpi 228 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 228 11 top top NN work_arndyvdyobgtlpeh4rho7pywpi 228 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 228 13 each each DT work_arndyvdyobgtlpeh4rho7pywpi 228 14 lane lane NN work_arndyvdyobgtlpeh4rho7pywpi 228 15 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 228 16 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 228 17 incubated incubate VBN work_arndyvdyobgtlpeh4rho7pywpi 228 18 in in IN work_arndyvdyobgtlpeh4rho7pywpi 228 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 228 20 presence presence NN work_arndyvdyobgtlpeh4rho7pywpi 228 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 228 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 228 23 labeled label VBN work_arndyvdyobgtlpeh4rho7pywpi 228 24 vitamin vitamin NN work_arndyvdyobgtlpeh4rho7pywpi 228 25 and and CC work_arndyvdyobgtlpeh4rho7pywpi 228 26 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 228 27 lysed lyse VBN work_arndyvdyobgtlpeh4rho7pywpi 228 28 , , , work_arndyvdyobgtlpeh4rho7pywpi 228 29 and and CC work_arndyvdyobgtlpeh4rho7pywpi 228 30 the the DT work_arndyvdyobgtlpeh4rho7pywpi 228 31 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 228 32 extracts extract NNS work_arndyvdyobgtlpeh4rho7pywpi 228 33 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 228 34 loaded load VBN work_arndyvdyobgtlpeh4rho7pywpi 228 35 onto onto IN work_arndyvdyobgtlpeh4rho7pywpi 228 36 a a DT work_arndyvdyobgtlpeh4rho7pywpi 228 37 7.5 7.5 CD work_arndyvdyobgtlpeh4rho7pywpi 228 38 % % NN work_arndyvdyobgtlpeh4rho7pywpi 228 39 SDS sds NN work_arndyvdyobgtlpeh4rho7pywpi 228 40 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 228 41 polyacrylamide polyacrylamide NNP work_arndyvdyobgtlpeh4rho7pywpi 228 42 gel gel NN work_arndyvdyobgtlpeh4rho7pywpi 228 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 229 1 Labeled label VBN work_arndyvdyobgtlpeh4rho7pywpi 229 2 proteins protein NNS work_arndyvdyobgtlpeh4rho7pywpi 229 3 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 229 4 revealed reveal VBN work_arndyvdyobgtlpeh4rho7pywpi 229 5 by by IN work_arndyvdyobgtlpeh4rho7pywpi 229 6 fluorography fluorography NN work_arndyvdyobgtlpeh4rho7pywpi 229 7 . . . work_arndyvdyobgtlpeh4rho7pywpi 230 1 Table table NN work_arndyvdyobgtlpeh4rho7pywpi 230 2 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 230 3 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 230 4 and and CC work_arndyvdyobgtlpeh4rho7pywpi 230 5 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 230 6 Mutations Mutations NNPS work_arndyvdyobgtlpeh4rho7pywpi 230 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 230 8 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 230 9 with with IN work_arndyvdyobgtlpeh4rho7pywpi 230 10 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 230 11 PATIENT PATIENT NNP work_arndyvdyobgtlpeh4rho7pywpi 230 12 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 230 13 ORIGIN ORIGIN NNP work_arndyvdyobgtlpeh4rho7pywpi 230 14 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 230 15 GROUP GROUP NNP work_arndyvdyobgtlpeh4rho7pywpi 230 16 a a DT work_arndyvdyobgtlpeh4rho7pywpi 230 17 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 230 18 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 230 19 3H]-BIOTIN 3h]-biotin CD work_arndyvdyobgtlpeh4rho7pywpi 230 20 LABELING labeling NN work_arndyvdyobgtlpeh4rho7pywpi 230 21 ? ? . work_arndyvdyobgtlpeh4rho7pywpi 231 1 MUTATION mutation NN work_arndyvdyobgtlpeh4rho7pywpi 231 2 IN in IN work_arndyvdyobgtlpeh4rho7pywpi 231 3 b b NN work_arndyvdyobgtlpeh4rho7pywpi 231 4 NUCLEOTIDE NUCLEOTIDE NNP work_arndyvdyobgtlpeh4rho7pywpi 231 5 CHANGE CHANGE NNS work_arndyvdyobgtlpeh4rho7pywpi 231 6 c c NN work_arndyvdyobgtlpeh4rho7pywpi 231 7 PREDICTED predict VBD work_arndyvdyobgtlpeh4rho7pywpi 231 8 CONSEQUENCE(S)MCCA CONSEQUENCE(S)MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 231 9 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 10 15468 15468 CD work_arndyvdyobgtlpeh4rho7pywpi 231 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 12 Spain Spain NNP work_arndyvdyobgtlpeh4rho7pywpi 231 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 14 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 15 Yes Yes NNP work_arndyvdyobgtlpeh4rho7pywpi 231 16 C167R C167R NNP work_arndyvdyobgtlpeh4rho7pywpi 231 17 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 18 c. c. NN work_arndyvdyobgtlpeh4rho7pywpi 231 19 499TrC 499trc CD work_arndyvdyobgtlpeh4rho7pywpi 231 20 Cys167Arg cys167arg NN work_arndyvdyobgtlpeh4rho7pywpi 231 21 substitution substitution NN work_arndyvdyobgtlpeh4rho7pywpi 231 22 in in IN work_arndyvdyobgtlpeh4rho7pywpi 231 23 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 231 24 15469 15469 CD work_arndyvdyobgtlpeh4rho7pywpi 231 25 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 26 Argentina Argentina NNP work_arndyvdyobgtlpeh4rho7pywpi 231 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 28 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 29 Yes Yes NNP work_arndyvdyobgtlpeh4rho7pywpi 231 30 A218 A218 NNP work_arndyvdyobgtlpeh4rho7pywpi 231 31 T T NNP work_arndyvdyobgtlpeh4rho7pywpi 231 32 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 33 c. c. NN work_arndyvdyobgtlpeh4rho7pywpi 231 34 652GrA 652gra CD work_arndyvdyobgtlpeh4rho7pywpi 231 35 Ala218Thr Ala218Thr NNP work_arndyvdyobgtlpeh4rho7pywpi 231 36 substitution substitution NN work_arndyvdyobgtlpeh4rho7pywpi 231 37 in in IN work_arndyvdyobgtlpeh4rho7pywpi 231 38 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 231 39 15626 15626 CD work_arndyvdyobgtlpeh4rho7pywpi 231 40 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 41 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 231 42 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 231 43 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 44 … … NFP work_arndyvdyobgtlpeh4rho7pywpi 231 45 Yes yes UH work_arndyvdyobgtlpeh4rho7pywpi 231 46 D172fs D172fs NNP work_arndyvdyobgtlpeh4rho7pywpi 231 47 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 48 c. c. NNP work_arndyvdyobgtlpeh4rho7pywpi 231 49 517insT 517insT NNP work_arndyvdyobgtlpeh4rho7pywpi 231 50 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 231 51 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 231 52 frameshifted frameshifte VBN work_arndyvdyobgtlpeh4rho7pywpi 231 53 after after IN work_arndyvdyobgtlpeh4rho7pywpi 231 54 residue residue JJ work_arndyvdyobgtlpeh4rho7pywpi 231 55 172 172 CD work_arndyvdyobgtlpeh4rho7pywpi 231 56 15628 15628 CD work_arndyvdyobgtlpeh4rho7pywpi 231 57 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 58 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 231 59 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 231 60 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 61 … … NFP work_arndyvdyobgtlpeh4rho7pywpi 231 62 Yes yes UH work_arndyvdyobgtlpeh4rho7pywpi 231 63 D172fs D172fs NNP work_arndyvdyobgtlpeh4rho7pywpi 231 64 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 65 c. c. NNP work_arndyvdyobgtlpeh4rho7pywpi 231 66 517insT 517insT NNP work_arndyvdyobgtlpeh4rho7pywpi 231 67 MCCb MCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 231 68 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 231 69 frameshifted frameshifte VBN work_arndyvdyobgtlpeh4rho7pywpi 231 70 after after IN work_arndyvdyobgtlpeh4rho7pywpi 231 71 residue residue NNP work_arndyvdyobgtlpeh4rho7pywpi 231 72 172 172 CD work_arndyvdyobgtlpeh4rho7pywpi 231 73 15767 15767 CD work_arndyvdyobgtlpeh4rho7pywpi 231 74 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 75 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 231 76 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 231 77 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 78 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 79 Yes yes UH work_arndyvdyobgtlpeh4rho7pywpi 231 80 IVS3 IVS3 NNP work_arndyvdyobgtlpeh4rho7pywpi 231 81 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 231 82 5rT 5rt CD work_arndyvdyobgtlpeh4rho7pywpi 231 83 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 84 c. c. NNP work_arndyvdyobgtlpeh4rho7pywpi 231 85 281 281 CD work_arndyvdyobgtlpeh4rho7pywpi 231 86 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 231 87 5GrT 5grt CD work_arndyvdyobgtlpeh4rho7pywpi 231 88 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 231 89 exon exon VBZ work_arndyvdyobgtlpeh4rho7pywpi 231 90 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 231 91 skipping skipping NN work_arndyvdyobgtlpeh4rho7pywpi 231 92 , , , work_arndyvdyobgtlpeh4rho7pywpi 231 93 frameshift frameshift NN work_arndyvdyobgtlpeh4rho7pywpi 231 94 after after IN work_arndyvdyobgtlpeh4rho7pywpi 231 95 residue residue NN work_arndyvdyobgtlpeh4rho7pywpi 231 96 66 66 CD work_arndyvdyobgtlpeh4rho7pywpi 231 97 15765 15765 CD work_arndyvdyobgtlpeh4rho7pywpi 231 98 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 99 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 231 100 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 231 101 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 102 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 231 103 No no DT work_arndyvdyobgtlpeh4rho7pywpi 231 104 M325R M325R NNP work_arndyvdyobgtlpeh4rho7pywpi 231 105 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 231 106 c.974TrG c.974trg NN work_arndyvdyobgtlpeh4rho7pywpi 231 107 Met325Arg met325arg NN work_arndyvdyobgtlpeh4rho7pywpi 231 108 substitution substitution NN work_arndyvdyobgtlpeh4rho7pywpi 231 109 in in IN work_arndyvdyobgtlpeh4rho7pywpi 231 110 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 231 111 15766 15766 CD work_arndyvdyobgtlpeh4rho7pywpi 231 112 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 113 United United NNP work_arndyvdyobgtlpeh4rho7pywpi 231 114 States States NNP work_arndyvdyobgtlpeh4rho7pywpi 231 115 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 116 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 231 117 Yes yes UH work_arndyvdyobgtlpeh4rho7pywpi 231 118 R385S r385s NN work_arndyvdyobgtlpeh4rho7pywpi 231 119 MCCA mcca NN work_arndyvdyobgtlpeh4rho7pywpi 231 120 c.1155ArC c.1155arc NN work_arndyvdyobgtlpeh4rho7pywpi 231 121 Arg385Ser arg385ser NN work_arndyvdyobgtlpeh4rho7pywpi 231 122 substitution substitution NN work_arndyvdyobgtlpeh4rho7pywpi 231 123 in in IN work_arndyvdyobgtlpeh4rho7pywpi 231 124 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 231 125 a a DT work_arndyvdyobgtlpeh4rho7pywpi 231 126 An an DT work_arndyvdyobgtlpeh4rho7pywpi 231 127 ellipsis ellipsis NN work_arndyvdyobgtlpeh4rho7pywpi 231 128 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 231 129 … … NFP work_arndyvdyobgtlpeh4rho7pywpi 231 130 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 231 131 denotes denote VBZ work_arndyvdyobgtlpeh4rho7pywpi 231 132 that that IN work_arndyvdyobgtlpeh4rho7pywpi 231 133 the the DT work_arndyvdyobgtlpeh4rho7pywpi 231 134 individual individual NN work_arndyvdyobgtlpeh4rho7pywpi 231 135 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 231 136 not not RB work_arndyvdyobgtlpeh4rho7pywpi 231 137 classified classify VBN work_arndyvdyobgtlpeh4rho7pywpi 231 138 . . . work_arndyvdyobgtlpeh4rho7pywpi 232 1 b b LS work_arndyvdyobgtlpeh4rho7pywpi 232 2 Found find VBN work_arndyvdyobgtlpeh4rho7pywpi 232 3 in in IN work_arndyvdyobgtlpeh4rho7pywpi 232 4 apparent apparent JJ work_arndyvdyobgtlpeh4rho7pywpi 232 5 homozygosis homozygosis NN work_arndyvdyobgtlpeh4rho7pywpi 232 6 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 232 7 or or CC work_arndyvdyobgtlpeh4rho7pywpi 232 8 in in IN work_arndyvdyobgtlpeh4rho7pywpi 232 9 a a DT work_arndyvdyobgtlpeh4rho7pywpi 232 10 hemizygosis hemizygosis NN work_arndyvdyobgtlpeh4rho7pywpi 232 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 232 12 like like JJ work_arndyvdyobgtlpeh4rho7pywpi 232 13 situation situation NN work_arndyvdyobgtlpeh4rho7pywpi 232 14 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 232 15 see see VB work_arndyvdyobgtlpeh4rho7pywpi 232 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 232 17 text text NN work_arndyvdyobgtlpeh4rho7pywpi 232 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 232 19 . . . work_arndyvdyobgtlpeh4rho7pywpi 233 1 Missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 233 2 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 233 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 233 4 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 233 5 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 233 6 underlined underline VBN work_arndyvdyobgtlpeh4rho7pywpi 233 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 233 8 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 233 9 absent absent JJ work_arndyvdyobgtlpeh4rho7pywpi 233 10 from from IN work_arndyvdyobgtlpeh4rho7pywpi 233 11 100 100 CD work_arndyvdyobgtlpeh4rho7pywpi 233 12 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 233 13 chromosomes chromosome NNS work_arndyvdyobgtlpeh4rho7pywpi 233 14 . . . work_arndyvdyobgtlpeh4rho7pywpi 234 1 c c LS work_arndyvdyobgtlpeh4rho7pywpi 234 2 Nucleotide Nucleotide NNP work_arndyvdyobgtlpeh4rho7pywpi 234 3 numbering numbering NN work_arndyvdyobgtlpeh4rho7pywpi 234 4 referred refer VBD work_arndyvdyobgtlpeh4rho7pywpi 234 5 to to IN work_arndyvdyobgtlpeh4rho7pywpi 234 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 234 7 A a NN work_arndyvdyobgtlpeh4rho7pywpi 234 8 in in IN work_arndyvdyobgtlpeh4rho7pywpi 234 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 234 10 initiation initiation NN work_arndyvdyobgtlpeh4rho7pywpi 234 11 ATG ATG NNP work_arndyvdyobgtlpeh4rho7pywpi 234 12 codons codon NNS work_arndyvdyobgtlpeh4rho7pywpi 234 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 234 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 234 15 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 234 16 sequences sequences NNPS work_arndyvdyobgtlpeh4rho7pywpi 234 17 in in IN work_arndyvdyobgtlpeh4rho7pywpi 234 18 figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 234 19 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 234 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 234 21 isovaleryl isovaleryl NNP work_arndyvdyobgtlpeh4rho7pywpi 234 22 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 234 23 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 234 24 dehydrogenase dehydrogenase NN work_arndyvdyobgtlpeh4rho7pywpi 234 25 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 234 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 234 27 these these DT work_arndyvdyobgtlpeh4rho7pywpi 234 28 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 234 29 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 234 30 closely closely RB work_arndyvdyobgtlpeh4rho7pywpi 234 31 linked link VBN work_arndyvdyobgtlpeh4rho7pywpi 234 32 within within IN work_arndyvdyobgtlpeh4rho7pywpi 234 33 a a DT work_arndyvdyobgtlpeh4rho7pywpi 234 34 14-kb 14-kb NNP work_arndyvdyobgtlpeh4rho7pywpi 234 35 region region NN work_arndyvdyobgtlpeh4rho7pywpi 234 36 , , , work_arndyvdyobgtlpeh4rho7pywpi 234 37 in in IN work_arndyvdyobgtlpeh4rho7pywpi 234 38 a a DT work_arndyvdyobgtlpeh4rho7pywpi 234 39 likely likely JJ work_arndyvdyobgtlpeh4rho7pywpi 234 40 leucine- leucine- JJ work_arndyvdyobgtlpeh4rho7pywpi 234 41 degradation degradation NN work_arndyvdyobgtlpeh4rho7pywpi 234 42 cluster cluster NN work_arndyvdyobgtlpeh4rho7pywpi 234 43 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 234 44 J.M.R. J.M.R. NNP work_arndyvdyobgtlpeh4rho7pywpi 235 1 and and CC work_arndyvdyobgtlpeh4rho7pywpi 235 2 M.A.P M.A.P NNP work_arndyvdyobgtlpeh4rho7pywpi 235 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 235 4 unpublished unpublished JJ work_arndyvdyobgtlpeh4rho7pywpi 235 5 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 235 6 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 235 7 . . . work_arndyvdyobgtlpeh4rho7pywpi 236 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 236 2 constructed construct VBD work_arndyvdyobgtlpeh4rho7pywpi 236 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 236 4 by by IN work_arndyvdyobgtlpeh4rho7pywpi 236 5 homologous homologous JJ work_arndyvdyobgtlpeh4rho7pywpi 236 6 recombination recombination NN work_arndyvdyobgtlpeh4rho7pywpi 236 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 236 8 a a DT work_arndyvdyobgtlpeh4rho7pywpi 236 9 null null NN work_arndyvdyobgtlpeh4rho7pywpi 236 10 DmccA DmccA NNP work_arndyvdyobgtlpeh4rho7pywpi 236 11 strain strain NN work_arndyvdyobgtlpeh4rho7pywpi 236 12 . . . work_arndyvdyobgtlpeh4rho7pywpi 237 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 237 2 contrast contrast NN work_arndyvdyobgtlpeh4rho7pywpi 237 3 to to IN work_arndyvdyobgtlpeh4rho7pywpi 237 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 237 5 parental parental JJ work_arndyvdyobgtlpeh4rho7pywpi 237 6 strain strain NN work_arndyvdyobgtlpeh4rho7pywpi 237 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 237 8 this this DT work_arndyvdyobgtlpeh4rho7pywpi 237 9 DmccA DmccA NNP work_arndyvdyobgtlpeh4rho7pywpi 237 10 strain strain NN work_arndyvdyobgtlpeh4rho7pywpi 237 11 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 237 12 unable unable JJ work_arndyvdyobgtlpeh4rho7pywpi 237 13 to to TO work_arndyvdyobgtlpeh4rho7pywpi 237 14 utilize utilize VB work_arndyvdyobgtlpeh4rho7pywpi 237 15 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 237 16 but but CC work_arndyvdyobgtlpeh4rho7pywpi 237 17 grows grow VBZ work_arndyvdyobgtlpeh4rho7pywpi 237 18 normally normally RB work_arndyvdyobgtlpeh4rho7pywpi 237 19 on on IN work_arndyvdyobgtlpeh4rho7pywpi 237 20 threonine threonine NN work_arndyvdyobgtlpeh4rho7pywpi 237 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 237 22 isoleucine isoleucine NN work_arndyvdyobgtlpeh4rho7pywpi 237 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 237 24 or or CC work_arndyvdyobgtlpeh4rho7pywpi 237 25 valine valine NN work_arndyvdyobgtlpeh4rho7pywpi 237 26 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 237 27 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 237 28 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 237 29 catabolized catabolize VBN work_arndyvdyobgtlpeh4rho7pywpi 237 30 via via IN work_arndyvdyobgtlpeh4rho7pywpi 237 31 propionyl propionyl NN work_arndyvdyobgtlpeh4rho7pywpi 237 32 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 237 33 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 237 34 and and CC work_arndyvdyobgtlpeh4rho7pywpi 237 35 PCC PCC NNP work_arndyvdyobgtlpeh4rho7pywpi 237 36 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 237 37 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 237 38 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 237 39 . . . work_arndyvdyobgtlpeh4rho7pywpi 238 1 6 6 LS work_arndyvdyobgtlpeh4rho7pywpi 238 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 238 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 239 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 239 2 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 239 3 establish establish VBP work_arndyvdyobgtlpeh4rho7pywpi 239 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 239 5 vivo vivo NNP work_arndyvdyobgtlpeh4rho7pywpi 239 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 239 7 specific specific JJ work_arndyvdyobgtlpeh4rho7pywpi 239 8 involvement involvement NN work_arndyvdyobgtlpeh4rho7pywpi 239 9 of of IN work_arndyvdyobgtlpeh4rho7pywpi 239 10 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 239 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 239 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 239 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 239 14 by by IN work_arndyvdyobgtlpeh4rho7pywpi 239 15 extension extension NN work_arndyvdyobgtlpeh4rho7pywpi 239 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 239 17 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 239 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 239 19 in in IN work_arndyvdyobgtlpeh4rho7pywpi 239 20 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 239 21 catabolism catabolism NN work_arndyvdyobgtlpeh4rho7pywpi 239 22 . . . work_arndyvdyobgtlpeh4rho7pywpi 240 1 Discussion discussion NN work_arndyvdyobgtlpeh4rho7pywpi 240 2 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 240 3 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 240 4 characterized characterize VBN work_arndyvdyobgtlpeh4rho7pywpi 240 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 240 6 at at IN work_arndyvdyobgtlpeh4rho7pywpi 240 7 both both CC work_arndyvdyobgtlpeh4rho7pywpi 240 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 240 9 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 240 10 level level NN work_arndyvdyobgtlpeh4rho7pywpi 240 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 240 12 the the DT work_arndyvdyobgtlpeh4rho7pywpi 240 13 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 240 14 level level NN work_arndyvdyobgtlpeh4rho7pywpi 240 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 240 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 240 17 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 240 18 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 240 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 240 20 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 240 21 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 240 22 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 240 23 the the DT work_arndyvdyobgtlpeh4rho7pywpi 240 24 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 240 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 240 26 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 240 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 240 28 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 240 29 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 240 30 an an DT work_arndyvdyobgtlpeh4rho7pywpi 240 31 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 240 32 of of IN work_arndyvdyobgtlpeh4rho7pywpi 240 33 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 240 34 catabolism catabolism NN work_arndyvdyobgtlpeh4rho7pywpi 240 35 and and CC work_arndyvdyobgtlpeh4rho7pywpi 240 36 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 240 37 , , , work_arndyvdyobgtlpeh4rho7pywpi 240 38 when when WRB work_arndyvdyobgtlpeh4rho7pywpi 240 39 deficient deficient JJ work_arndyvdyobgtlpeh4rho7pywpi 240 40 , , , work_arndyvdyobgtlpeh4rho7pywpi 240 41 leads lead VBZ work_arndyvdyobgtlpeh4rho7pywpi 240 42 to to IN work_arndyvdyobgtlpeh4rho7pywpi 240 43 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 240 44 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 240 45 and and CC work_arndyvdyobgtlpeh4rho7pywpi 240 46 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 240 47 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 240 48 detected detect VBN work_arndyvdyobgtlpeh4rho7pywpi 240 49 six six CD work_arndyvdyobgtlpeh4rho7pywpi 240 50 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 240 51 or or CC work_arndyvdyobgtlpeh4rho7pywpi 240 52 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 240 53 mu- mu- NNP work_arndyvdyobgtlpeh4rho7pywpi 240 54 tations tation NNS work_arndyvdyobgtlpeh4rho7pywpi 240 55 in in IN work_arndyvdyobgtlpeh4rho7pywpi 240 56 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 240 57 diagnosed diagnose VBN work_arndyvdyobgtlpeh4rho7pywpi 240 58 with with IN work_arndyvdyobgtlpeh4rho7pywpi 240 59 the the DT work_arndyvdyobgtlpeh4rho7pywpi 240 60 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 240 61 . . . work_arndyvdyobgtlpeh4rho7pywpi 241 1 All all PDT work_arndyvdyobgtlpeh4rho7pywpi 241 2 these these DT work_arndyvdyobgtlpeh4rho7pywpi 241 3 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 241 4 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 241 5 most most RBS work_arndyvdyobgtlpeh4rho7pywpi 241 6 likely likely JJ work_arndyvdyobgtlpeh4rho7pywpi 241 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 241 8 homozygosis homozygosis NN work_arndyvdyobgtlpeh4rho7pywpi 241 9 . . . work_arndyvdyobgtlpeh4rho7pywpi 242 1 However however RB work_arndyvdyobgtlpeh4rho7pywpi 242 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 242 3 since since IN work_arndyvdyobgtlpeh4rho7pywpi 242 4 no no DT work_arndyvdyobgtlpeh4rho7pywpi 242 5 relatives relative NNS work_arndyvdyobgtlpeh4rho7pywpi 242 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 242 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 242 8 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 242 9 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 242 10 available available JJ work_arndyvdyobgtlpeh4rho7pywpi 242 11 for for IN work_arndyvdyobgtlpeh4rho7pywpi 242 12 seg- seg- NNP work_arndyvdyobgtlpeh4rho7pywpi 242 13 regation regation NN work_arndyvdyobgtlpeh4rho7pywpi 242 14 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 242 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 242 16 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 242 17 can can MD work_arndyvdyobgtlpeh4rho7pywpi 242 18 not not RB work_arndyvdyobgtlpeh4rho7pywpi 242 19 formally formally RB work_arndyvdyobgtlpeh4rho7pywpi 242 20 rule rule VB work_arndyvdyobgtlpeh4rho7pywpi 242 21 out out RP work_arndyvdyobgtlpeh4rho7pywpi 242 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 242 23 pos- pos- JJ work_arndyvdyobgtlpeh4rho7pywpi 242 24 sibility sibility NN work_arndyvdyobgtlpeh4rho7pywpi 242 25 that that IN work_arndyvdyobgtlpeh4rho7pywpi 242 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 242 27 among among IN work_arndyvdyobgtlpeh4rho7pywpi 242 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 242 29 probands proband NNS work_arndyvdyobgtlpeh4rho7pywpi 242 30 , , , work_arndyvdyobgtlpeh4rho7pywpi 242 31 there there EX work_arndyvdyobgtlpeh4rho7pywpi 242 32 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 242 33 compound compound NN work_arndyvdyobgtlpeh4rho7pywpi 242 34 heterozygotes heterozygote NNS work_arndyvdyobgtlpeh4rho7pywpi 242 35 carrying carry VBG work_arndyvdyobgtlpeh4rho7pywpi 242 36 a a DT work_arndyvdyobgtlpeh4rho7pywpi 242 37 partial partial JJ work_arndyvdyobgtlpeh4rho7pywpi 242 38 or or CC work_arndyvdyobgtlpeh4rho7pywpi 242 39 complete complete JJ work_arndyvdyobgtlpeh4rho7pywpi 242 40 deletion deletion NN work_arndyvdyobgtlpeh4rho7pywpi 242 41 of of IN work_arndyvdyobgtlpeh4rho7pywpi 242 42 either either CC work_arndyvdyobgtlpeh4rho7pywpi 242 43 the the DT work_arndyvdyobgtlpeh4rho7pywpi 242 44 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 242 45 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 242 46 or or CC work_arndyvdyobgtlpeh4rho7pywpi 242 47 the the DT work_arndyvdyobgtlpeh4rho7pywpi 242 48 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 242 49 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 242 50 . . . work_arndyvdyobgtlpeh4rho7pywpi 243 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 243 2 six six CD work_arndyvdyobgtlpeh4rho7pywpi 243 3 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 243 4 reported report VBN work_arndyvdyobgtlpeh4rho7pywpi 243 5 here here RB work_arndyvdyobgtlpeh4rho7pywpi 243 6 fulfill fulfill VB work_arndyvdyobgtlpeh4rho7pywpi 243 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 8 criteria criterion NNS work_arndyvdyobgtlpeh4rho7pywpi 243 9 for for IN work_arndyvdyobgtlpeh4rho7pywpi 243 10 pathogenic pathogenic JJ work_arndyvdyobgtlpeh4rho7pywpi 243 11 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 243 12 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 13 Cotton Cotton NNP work_arndyvdyobgtlpeh4rho7pywpi 243 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 243 15 Horaitis Horaitis NNP work_arndyvdyobgtlpeh4rho7pywpi 243 16 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 243 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 18 : : : work_arndyvdyobgtlpeh4rho7pywpi 243 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 20 i i NN work_arndyvdyobgtlpeh4rho7pywpi 243 21 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 22 each each DT work_arndyvdyobgtlpeh4rho7pywpi 243 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 24 these these DT work_arndyvdyobgtlpeh4rho7pywpi 243 25 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 243 26 was be VBD work_arndyvdyobgtlpeh4rho7pywpi 243 27 detected detect VBN work_arndyvdyobgtlpeh4rho7pywpi 243 28 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 29 a a DT work_arndyvdyobgtlpeh4rho7pywpi 243 30 particular particular JJ work_arndyvdyobgtlpeh4rho7pywpi 243 31 proband proband NN work_arndyvdyobgtlpeh4rho7pywpi 243 32 after after IN work_arndyvdyobgtlpeh4rho7pywpi 243 33 direct direct JJ work_arndyvdyobgtlpeh4rho7pywpi 243 34 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 243 35 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 36 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 37 complete complete JJ work_arndyvdyobgtlpeh4rho7pywpi 243 38 coding coding NN work_arndyvdyobgtlpeh4rho7pywpi 243 39 region region NN work_arndyvdyobgtlpeh4rho7pywpi 243 40 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 41 either either DT work_arndyvdyobgtlpeh4rho7pywpi 243 42 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 243 43 or or CC work_arndyvdyobgtlpeh4rho7pywpi 243 44 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 243 45 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 46 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 47 ii ii NNP work_arndyvdyobgtlpeh4rho7pywpi 243 48 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 49 they -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 243 50 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 243 51 con- con- NN work_arndyvdyobgtlpeh4rho7pywpi 243 52 firmed firm VBN work_arndyvdyobgtlpeh4rho7pywpi 243 53 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 54 two two CD work_arndyvdyobgtlpeh4rho7pywpi 243 55 independent independent JJ work_arndyvdyobgtlpeh4rho7pywpi 243 56 RT RT NNP work_arndyvdyobgtlpeh4rho7pywpi 243 57 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 243 58 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 243 59 experiments experiment NNS work_arndyvdyobgtlpeh4rho7pywpi 243 60 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 61 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 62 iii iii NNP work_arndyvdyobgtlpeh4rho7pywpi 243 63 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 64 they -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 243 65 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 243 66 confirmed confirm VBN work_arndyvdyobgtlpeh4rho7pywpi 243 67 by by IN work_arndyvdyobgtlpeh4rho7pywpi 243 68 direct direct JJ work_arndyvdyobgtlpeh4rho7pywpi 243 69 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 243 70 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 71 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 243 72 DNA dna NN work_arndyvdyobgtlpeh4rho7pywpi 243 73 ; ; , work_arndyvdyobgtlpeh4rho7pywpi 243 74 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 75 iv iv LS work_arndyvdyobgtlpeh4rho7pywpi 243 76 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 77 they -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 243 78 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 243 79 confirmed confirm VBN work_arndyvdyobgtlpeh4rho7pywpi 243 80 by by IN work_arndyvdyobgtlpeh4rho7pywpi 243 81 RFLP RFLP NNP work_arndyvdyobgtlpeh4rho7pywpi 243 82 or or CC work_arndyvdyobgtlpeh4rho7pywpi 243 83 SSCP SSCP NNPS work_arndyvdyobgtlpeh4rho7pywpi 243 84 anal- anal- JJ work_arndyvdyobgtlpeh4rho7pywpi 243 85 ysis ysis NN work_arndyvdyobgtlpeh4rho7pywpi 243 86 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 87 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 88 corresponding correspond VBG work_arndyvdyobgtlpeh4rho7pywpi 243 89 amplified amplified JJ work_arndyvdyobgtlpeh4rho7pywpi 243 90 exons exon NNS work_arndyvdyobgtlpeh4rho7pywpi 243 91 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 92 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 93 v v LS work_arndyvdyobgtlpeh4rho7pywpi 243 94 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 95 all all DT work_arndyvdyobgtlpeh4rho7pywpi 243 96 six six CD work_arndyvdyobgtlpeh4rho7pywpi 243 97 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 243 98 absent absent JJ work_arndyvdyobgtlpeh4rho7pywpi 243 99 from from IN work_arndyvdyobgtlpeh4rho7pywpi 243 100 a a DT work_arndyvdyobgtlpeh4rho7pywpi 243 101 sample sample NN work_arndyvdyobgtlpeh4rho7pywpi 243 102 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 103 100 100 CD work_arndyvdyobgtlpeh4rho7pywpi 243 104 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 243 105 chromo- chromo- NN work_arndyvdyobgtlpeh4rho7pywpi 243 106 somes some NNS work_arndyvdyobgtlpeh4rho7pywpi 243 107 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 108 and and CC work_arndyvdyobgtlpeh4rho7pywpi 243 109 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 110 vi vi NNP work_arndyvdyobgtlpeh4rho7pywpi 243 111 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 112 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 113 M325R M325R NNP work_arndyvdyobgtlpeh4rho7pywpi 243 114 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 243 115 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 243 116 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 243 117 leads lead VBZ work_arndyvdyobgtlpeh4rho7pywpi 243 118 to to IN work_arndyvdyobgtlpeh4rho7pywpi 243 119 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 243 120 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 121 biotinylated biotinylated JJ work_arndyvdyobgtlpeh4rho7pywpi 243 122 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 243 123 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 124 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 243 125 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 243 126 a a DT work_arndyvdyobgtlpeh4rho7pywpi 243 127 for- for- NN work_arndyvdyobgtlpeh4rho7pywpi 243 128 mal mal JJ work_arndyvdyobgtlpeh4rho7pywpi 243 129 proof proof NN work_arndyvdyobgtlpeh4rho7pywpi 243 130 that that IN work_arndyvdyobgtlpeh4rho7pywpi 243 131 this this DT work_arndyvdyobgtlpeh4rho7pywpi 243 132 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 243 133 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 243 134 pathogenic pathogenic JJ work_arndyvdyobgtlpeh4rho7pywpi 243 135 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 136 since since IN work_arndyvdyobgtlpeh4rho7pywpi 243 137 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 138 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 243 139 cofactor cofactor NN work_arndyvdyobgtlpeh4rho7pywpi 243 140 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 243 141 essential essential JJ work_arndyvdyobgtlpeh4rho7pywpi 243 142 for for IN work_arndyvdyobgtlpeh4rho7pywpi 243 143 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 243 144 function function NN work_arndyvdyobgtlpeh4rho7pywpi 243 145 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 146 see see VB work_arndyvdyobgtlpeh4rho7pywpi 243 147 Wolf Wolf NNP work_arndyvdyobgtlpeh4rho7pywpi 243 148 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 243 149 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 150 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 151 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 152 vii vii NN work_arndyvdyobgtlpeh4rho7pywpi 243 153 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 154 Arg385 arg385 ADD work_arndyvdyobgtlpeh4rho7pywpi 243 155 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 156 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 157 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 243 158 residue residue NN work_arndyvdyobgtlpeh4rho7pywpi 243 159 affected affect VBN work_arndyvdyobgtlpeh4rho7pywpi 243 160 by by IN work_arndyvdyobgtlpeh4rho7pywpi 243 161 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 162 second second JJ work_arndyvdyobgtlpeh4rho7pywpi 243 163 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 243 164 missense missense NN work_arndyvdyobgtlpeh4rho7pywpi 243 165 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 243 166 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 167 R385S R385S NNP work_arndyvdyobgtlpeh4rho7pywpi 243 168 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 169 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 170 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 243 171 predicted predict VBN work_arndyvdyobgtlpeh4rho7pywpi 243 172 to to TO work_arndyvdyobgtlpeh4rho7pywpi 243 173 be be VB work_arndyvdyobgtlpeh4rho7pywpi 243 174 involved involve VBN work_arndyvdyobgtlpeh4rho7pywpi 243 175 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 176 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 177 binding binding NN work_arndyvdyobgtlpeh4rho7pywpi 243 178 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 179 one one CD work_arndyvdyobgtlpeh4rho7pywpi 243 180 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 181 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 182 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 243 183 substrates substrate NNS work_arndyvdyobgtlpeh4rho7pywpi 243 184 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 185 see see VB work_arndyvdyobgtlpeh4rho7pywpi 243 186 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 187 Results Results NNP work_arndyvdyobgtlpeh4rho7pywpi 243 188 section section NN work_arndyvdyobgtlpeh4rho7pywpi 243 189 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 190 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 191 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 192 viii viii UH work_arndyvdyobgtlpeh4rho7pywpi 243 193 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 194 D172fs D172fs NNP work_arndyvdyobgtlpeh4rho7pywpi 243 195 and and CC work_arndyvdyobgtlpeh4rho7pywpi 243 196 IVS3 IVS3 NNP work_arndyvdyobgtlpeh4rho7pywpi 243 197 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 243 198 5GrT 5grt CD work_arndyvdyobgtlpeh4rho7pywpi 243 199 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 200 two two CD work_arndyvdyobgtlpeh4rho7pywpi 243 201 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 202 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 203 four four CD work_arndyvdyobgtlpeh4rho7pywpi 243 204 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 243 205 found find VBN work_arndyvdyobgtlpeh4rho7pywpi 243 206 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 207 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 243 208 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 209 homozygosis homozygosis NN work_arndyvdyobgtlpeh4rho7pywpi 243 210 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 211 or or CC work_arndyvdyobgtlpeh4rho7pywpi 243 212 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 213 a a DT work_arndyvdyobgtlpeh4rho7pywpi 243 214 hemizygosis hemizygosis NN work_arndyvdyobgtlpeh4rho7pywpi 243 215 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 243 216 like like JJ work_arndyvdyobgtlpeh4rho7pywpi 243 217 situ- situ- JJ work_arndyvdyobgtlpeh4rho7pywpi 243 218 ation ation NN work_arndyvdyobgtlpeh4rho7pywpi 243 219 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 220 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 221 result result VBP work_arndyvdyobgtlpeh4rho7pywpi 243 222 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 223 early early JJ work_arndyvdyobgtlpeh4rho7pywpi 243 224 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 243 225 truncation truncation NN work_arndyvdyobgtlpeh4rho7pywpi 243 226 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 227 table table NN work_arndyvdyobgtlpeh4rho7pywpi 243 228 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 243 229 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 230 and and CC work_arndyvdyobgtlpeh4rho7pywpi 243 231 almost almost RB work_arndyvdyobgtlpeh4rho7pywpi 243 232 certainly certainly RB work_arndyvdyobgtlpeh4rho7pywpi 243 233 lead lead VBP work_arndyvdyobgtlpeh4rho7pywpi 243 234 to to IN work_arndyvdyobgtlpeh4rho7pywpi 243 235 null null NN work_arndyvdyobgtlpeh4rho7pywpi 243 236 alleles allele NNS work_arndyvdyobgtlpeh4rho7pywpi 243 237 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 243 238 and and CC work_arndyvdyobgtlpeh4rho7pywpi 243 239 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 240 ix ix IN work_arndyvdyobgtlpeh4rho7pywpi 243 241 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 242 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 243 other other JJ work_arndyvdyobgtlpeh4rho7pywpi 243 244 two two CD work_arndyvdyobgtlpeh4rho7pywpi 243 245 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 243 246 found find VBN work_arndyvdyobgtlpeh4rho7pywpi 243 247 in in IN work_arndyvdyobgtlpeh4rho7pywpi 243 248 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 243 249 involve involve VBP work_arndyvdyobgtlpeh4rho7pywpi 243 250 nonconservative nonconservative JJ work_arndyvdyobgtlpeh4rho7pywpi 243 251 substitutions substitution NNS work_arndyvdyobgtlpeh4rho7pywpi 243 252 of of IN work_arndyvdyobgtlpeh4rho7pywpi 243 253 residues residue NNS work_arndyvdyobgtlpeh4rho7pywpi 243 254 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 243 255 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 243 256 strictly strictly RB work_arndyvdyobgtlpeh4rho7pywpi 243 257 conserved conserve VBN work_arndyvdyobgtlpeh4rho7pywpi 243 258 among among IN work_arndyvdyobgtlpeh4rho7pywpi 243 259 the the DT work_arndyvdyobgtlpeh4rho7pywpi 243 260 three three CD work_arndyvdyobgtlpeh4rho7pywpi 243 261 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 243 262 sequences sequence NNS work_arndyvdyobgtlpeh4rho7pywpi 243 263 available available JJ work_arndyvdyobgtlpeh4rho7pywpi 243 264 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 243 265 i.e. i.e. FW work_arndyvdyobgtlpeh4rho7pywpi 243 266 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 267 hu- hu- XX work_arndyvdyobgtlpeh4rho7pywpi 243 268 man man NN work_arndyvdyobgtlpeh4rho7pywpi 243 269 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 270 Arabidopsis Arabidopsis NNP work_arndyvdyobgtlpeh4rho7pywpi 243 271 , , , work_arndyvdyobgtlpeh4rho7pywpi 243 272 and and CC work_arndyvdyobgtlpeh4rho7pywpi 243 273 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 243 274 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 243 275 . . . work_arndyvdyobgtlpeh4rho7pywpi 244 1 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 244 2 therefore therefore RB work_arndyvdyobgtlpeh4rho7pywpi 244 3 con- con- VBP work_arndyvdyobgtlpeh4rho7pywpi 244 4 clude clude VBP work_arndyvdyobgtlpeh4rho7pywpi 244 5 that that IN work_arndyvdyobgtlpeh4rho7pywpi 244 6 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 244 7 results result VBZ work_arndyvdyobgtlpeh4rho7pywpi 244 8 from from IN work_arndyvdyobgtlpeh4rho7pywpi 244 9 loss loss NN work_arndyvdyobgtlpeh4rho7pywpi 244 10 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 244 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 244 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 244 13 function function NN work_arndyvdyobgtlpeh4rho7pywpi 244 14 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 244 15 Gallardo Gallardo NNP work_arndyvdyobgtlpeh4rho7pywpi 244 16 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 244 17 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 244 18 . . . work_arndyvdyobgtlpeh4rho7pywpi 245 1 : : : work_arndyvdyobgtlpeh4rho7pywpi 245 2 3-Methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 245 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 245 4 CoA coa NN work_arndyvdyobgtlpeh4rho7pywpi 245 5 Carboxylase Carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 245 6 Deficiency Deficiency NNP work_arndyvdyobgtlpeh4rho7pywpi 245 7 343 343 CD work_arndyvdyobgtlpeh4rho7pywpi 245 8 Figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 245 9 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 245 10 Mutations Mutations NNPS work_arndyvdyobgtlpeh4rho7pywpi 245 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 245 12 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 245 13 and and CC work_arndyvdyobgtlpeh4rho7pywpi 245 14 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 245 15 . . . work_arndyvdyobgtlpeh4rho7pywpi 246 1 A a DT work_arndyvdyobgtlpeh4rho7pywpi 246 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 246 3 Mutations Mutations NNPS work_arndyvdyobgtlpeh4rho7pywpi 246 4 in in IN work_arndyvdyobgtlpeh4rho7pywpi 246 5 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 246 6 : : : work_arndyvdyobgtlpeh4rho7pywpi 246 7 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 246 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 246 9 direct direct JJ work_arndyvdyobgtlpeh4rho7pywpi 246 10 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 246 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 246 12 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 246 13 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 246 14 amplified amplify VBN work_arndyvdyobgtlpeh4rho7pywpi 246 15 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 246 16 DNA dna NN work_arndyvdyobgtlpeh4rho7pywpi 246 17 from from IN work_arndyvdyobgtlpeh4rho7pywpi 246 18 controls control NNS work_arndyvdyobgtlpeh4rho7pywpi 246 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 246 20 from from IN work_arndyvdyobgtlpeh4rho7pywpi 246 21 CGB CGB NNP work_arndyvdyobgtlpeh4rho7pywpi 246 22 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 246 23 who who WP work_arndyvdyobgtlpeh4rho7pywpi 246 24 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 246 25 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 246 26 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 246 27 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 246 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 247 1 Arrows arrow NNS work_arndyvdyobgtlpeh4rho7pywpi 247 2 indicate indicate VBP work_arndyvdyobgtlpeh4rho7pywpi 247 3 the the DT work_arndyvdyobgtlpeh4rho7pywpi 247 4 mutated mutate VBN work_arndyvdyobgtlpeh4rho7pywpi 247 5 positions position NNS work_arndyvdyobgtlpeh4rho7pywpi 247 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 248 1 B b NN work_arndyvdyobgtlpeh4rho7pywpi 248 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 248 3 Results result NNS work_arndyvdyobgtlpeh4rho7pywpi 248 4 of of IN work_arndyvdyobgtlpeh4rho7pywpi 248 5 direct direct JJ work_arndyvdyobgtlpeh4rho7pywpi 248 6 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 248 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 248 8 PCR- PCR- NNP work_arndyvdyobgtlpeh4rho7pywpi 248 9 amplified amplify VBN work_arndyvdyobgtlpeh4rho7pywpi 248 10 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 248 11 DNA dna NN work_arndyvdyobgtlpeh4rho7pywpi 248 12 from from IN work_arndyvdyobgtlpeh4rho7pywpi 248 13 controls control NNS work_arndyvdyobgtlpeh4rho7pywpi 248 14 and and CC work_arndyvdyobgtlpeh4rho7pywpi 248 15 from from IN work_arndyvdyobgtlpeh4rho7pywpi 248 16 CGA CGA NNP work_arndyvdyobgtlpeh4rho7pywpi 248 17 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 248 18 who who WP work_arndyvdyobgtlpeh4rho7pywpi 248 19 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 248 20 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 248 21 . . . work_arndyvdyobgtlpeh4rho7pywpi 249 1 Arrows arrow NNS work_arndyvdyobgtlpeh4rho7pywpi 249 2 indicate indicate VBP work_arndyvdyobgtlpeh4rho7pywpi 249 3 the the DT work_arndyvdyobgtlpeh4rho7pywpi 249 4 mutated mutate VBN work_arndyvdyobgtlpeh4rho7pywpi 249 5 positions position NNS work_arndyvdyobgtlpeh4rho7pywpi 249 6 . . . work_arndyvdyobgtlpeh4rho7pywpi 250 1 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 250 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 250 3 IVS3 IVS3 NNP work_arndyvdyobgtlpeh4rho7pywpi 250 4 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 250 5 5GrT 5grt CD work_arndyvdyobgtlpeh4rho7pywpi 250 6 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 250 7 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 250 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 250 9 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 250 10 results result VBZ work_arndyvdyobgtlpeh4rho7pywpi 250 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 250 12 skipping skipping NN work_arndyvdyobgtlpeh4rho7pywpi 250 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 250 14 exon exon NNP work_arndyvdyobgtlpeh4rho7pywpi 250 15 3 3 CD work_arndyvdyobgtlpeh4rho7pywpi 250 16 . . . work_arndyvdyobgtlpeh4rho7pywpi 251 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 251 2 gel gel NN work_arndyvdyobgtlpeh4rho7pywpi 251 3 shows show VBZ work_arndyvdyobgtlpeh4rho7pywpi 251 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 251 5 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 251 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 251 7 agarose agarose NN work_arndyvdyobgtlpeh4rho7pywpi 251 8 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 251 9 gel gel NN work_arndyvdyobgtlpeh4rho7pywpi 251 10 electrophoresis electrophoresis NN work_arndyvdyobgtlpeh4rho7pywpi 251 11 and and CC work_arndyvdyobgtlpeh4rho7pywpi 251 12 direct direct JJ work_arndyvdyobgtlpeh4rho7pywpi 251 13 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 251 14 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 251 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 251 16 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 251 17 cDNA cDNA NNP work_arndyvdyobgtlpeh4rho7pywpi 251 18 from from IN work_arndyvdyobgtlpeh4rho7pywpi 251 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 251 20 region region NN work_arndyvdyobgtlpeh4rho7pywpi 251 21 surrounding surround VBG work_arndyvdyobgtlpeh4rho7pywpi 251 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 251 23 exon2 exon2 NN work_arndyvdyobgtlpeh4rho7pywpi 251 24 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 251 25 exon3 exon3 NN work_arndyvdyobgtlpeh4rho7pywpi 251 26 junction junction NN work_arndyvdyobgtlpeh4rho7pywpi 251 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 251 28 amplified amplify VBN work_arndyvdyobgtlpeh4rho7pywpi 251 29 by by IN work_arndyvdyobgtlpeh4rho7pywpi 251 30 RT RT NNP work_arndyvdyobgtlpeh4rho7pywpi 251 31 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 251 32 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 251 33 with with IN work_arndyvdyobgtlpeh4rho7pywpi 251 34 fibroblast fibroblast NN work_arndyvdyobgtlpeh4rho7pywpi 251 35 mRNA mrna NN work_arndyvdyobgtlpeh4rho7pywpi 251 36 as as IN work_arndyvdyobgtlpeh4rho7pywpi 251 37 template template NN work_arndyvdyobgtlpeh4rho7pywpi 251 38 , , , work_arndyvdyobgtlpeh4rho7pywpi 251 39 from from IN work_arndyvdyobgtlpeh4rho7pywpi 251 40 a a DT work_arndyvdyobgtlpeh4rho7pywpi 251 41 control control NN work_arndyvdyobgtlpeh4rho7pywpi 251 42 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 251 43 lane lane NNP work_arndyvdyobgtlpeh4rho7pywpi 251 44 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 251 45 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 251 46 and and CC work_arndyvdyobgtlpeh4rho7pywpi 251 47 from from IN work_arndyvdyobgtlpeh4rho7pywpi 251 48 the the DT work_arndyvdyobgtlpeh4rho7pywpi 251 49 patient patient NN work_arndyvdyobgtlpeh4rho7pywpi 251 50 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 251 51 lane lane NNP work_arndyvdyobgtlpeh4rho7pywpi 251 52 P P NNP work_arndyvdyobgtlpeh4rho7pywpi 251 53 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 251 54 carrying carry VBG work_arndyvdyobgtlpeh4rho7pywpi 251 55 this this DT work_arndyvdyobgtlpeh4rho7pywpi 251 56 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 251 57 . . . work_arndyvdyobgtlpeh4rho7pywpi 252 1 Lane Lane NNP work_arndyvdyobgtlpeh4rho7pywpi 252 2 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 252 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 252 4 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 252 5 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 252 6 wieght wieght NN work_arndyvdyobgtlpeh4rho7pywpi 252 7 marker marker NN work_arndyvdyobgtlpeh4rho7pywpi 252 8 . . . work_arndyvdyobgtlpeh4rho7pywpi 253 1 in in IN work_arndyvdyobgtlpeh4rho7pywpi 253 2 either either DT work_arndyvdyobgtlpeh4rho7pywpi 253 3 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 253 4 or or CC work_arndyvdyobgtlpeh4rho7pywpi 253 5 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 253 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 253 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 253 8 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 253 9 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 253 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 253 11 a a NN work_arndyvdyobgtlpeh4rho7pywpi 253 12 and and CC work_arndyvdyobgtlpeh4rho7pywpi 253 13 b b NN work_arndyvdyobgtlpeh4rho7pywpi 253 14 subunits subunit NNS work_arndyvdyobgtlpeh4rho7pywpi 253 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 253 16 respectively respectively RB work_arndyvdyobgtlpeh4rho7pywpi 253 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 253 18 of of IN work_arndyvdyobgtlpeh4rho7pywpi 253 19 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 253 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 254 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 254 2 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 254 3 M325R M325R NNP work_arndyvdyobgtlpeh4rho7pywpi 254 4 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 254 5 leading lead VBG work_arndyvdyobgtlpeh4rho7pywpi 254 6 to to IN work_arndyvdyobgtlpeh4rho7pywpi 254 7 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 254 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 254 9 biotinylated biotinylated JJ work_arndyvdyobgtlpeh4rho7pywpi 254 10 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 254 11 deserves deserve VBZ work_arndyvdyobgtlpeh4rho7pywpi 254 12 particular particular JJ work_arndyvdyobgtlpeh4rho7pywpi 254 13 attention attention NN work_arndyvdyobgtlpeh4rho7pywpi 254 14 . . . work_arndyvdyobgtlpeh4rho7pywpi 255 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 255 2 hu- hu- DT work_arndyvdyobgtlpeh4rho7pywpi 255 3 man man NN work_arndyvdyobgtlpeh4rho7pywpi 255 4 PCCa PCCa NNPS work_arndyvdyobgtlpeh4rho7pywpi 255 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 255 6 a a DT work_arndyvdyobgtlpeh4rho7pywpi 255 7 polypeptide polypeptide NN work_arndyvdyobgtlpeh4rho7pywpi 255 8 comprising comprise VBG work_arndyvdyobgtlpeh4rho7pywpi 255 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 255 10 carboxyl carboxyl NN work_arndyvdyobgtlpeh4rho7pywpi 255 11 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 255 12 ter- ter- NNP work_arndyvdyobgtlpeh4rho7pywpi 255 13 minal minal JJ work_arndyvdyobgtlpeh4rho7pywpi 255 14 67 67 CD work_arndyvdyobgtlpeh4rho7pywpi 255 15 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 255 16 acids acid NNS work_arndyvdyobgtlpeh4rho7pywpi 255 17 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 255 18 include include VBP work_arndyvdyobgtlpeh4rho7pywpi 255 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 255 20 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 255 21 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 255 22 attachment attachment NN work_arndyvdyobgtlpeh4rho7pywpi 255 23 sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 255 24 Ala Ala NNP work_arndyvdyobgtlpeh4rho7pywpi 255 25 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 255 26 Met Met NNP work_arndyvdyobgtlpeh4rho7pywpi 255 27 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 255 28 Lys Lys NNP work_arndyvdyobgtlpeh4rho7pywpi 255 29 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 255 30 Met Met NNP work_arndyvdyobgtlpeh4rho7pywpi 255 31 functions function NNS work_arndyvdyobgtlpeh4rho7pywpi 255 32 as as IN work_arndyvdyobgtlpeh4rho7pywpi 255 33 an an DT work_arndyvdyobgtlpeh4rho7pywpi 255 34 independent independent JJ work_arndyvdyobgtlpeh4rho7pywpi 255 35 domain domain NN work_arndyvdyobgtlpeh4rho7pywpi 255 36 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 255 37 can can MD work_arndyvdyobgtlpeh4rho7pywpi 255 38 be be VB work_arndyvdyobgtlpeh4rho7pywpi 255 39 biotinylated biotinylate VBN work_arndyvdyobgtlpeh4rho7pywpi 255 40 in in IN work_arndyvdyobgtlpeh4rho7pywpi 255 41 E. E. NNP work_arndyvdyobgtlpeh4rho7pywpi 255 42 coli coli NNS work_arndyvdyobgtlpeh4rho7pywpi 255 43 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 255 44 León León NNP work_arndyvdyobgtlpeh4rho7pywpi 255 45 del del NNP work_arndyvdyobgtlpeh4rho7pywpi 255 46 Rı́o Rı́o NNP work_arndyvdyobgtlpeh4rho7pywpi 255 47 and and CC work_arndyvdyobgtlpeh4rho7pywpi 255 48 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 255 49 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 255 50 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 255 51 . . . work_arndyvdyobgtlpeh4rho7pywpi 256 1 Met325 Met325 NNS work_arndyvdyobgtlpeh4rho7pywpi 256 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 256 3 affected affect VBN work_arndyvdyobgtlpeh4rho7pywpi 256 4 by by IN work_arndyvdyobgtlpeh4rho7pywpi 256 5 this this DT work_arndyvdyobgtlpeh4rho7pywpi 256 6 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 256 7 mu- mu- NN work_arndyvdyobgtlpeh4rho7pywpi 256 8 tation tation NN work_arndyvdyobgtlpeh4rho7pywpi 256 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 256 10 lies lie VBZ work_arndyvdyobgtlpeh4rho7pywpi 256 11 considerably considerably RB work_arndyvdyobgtlpeh4rho7pywpi 256 12 upstream upstream RB work_arndyvdyobgtlpeh4rho7pywpi 256 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 256 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 256 15 corresponding corresponding JJ work_arndyvdyobgtlpeh4rho7pywpi 256 16 region region NN work_arndyvdyobgtlpeh4rho7pywpi 256 17 in in IN work_arndyvdyobgtlpeh4rho7pywpi 256 18 hMCCa hMCCa NNP work_arndyvdyobgtlpeh4rho7pywpi 256 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 256 20 see see UH work_arndyvdyobgtlpeh4rho7pywpi 256 21 fig fig NN work_arndyvdyobgtlpeh4rho7pywpi 256 22 . . . work_arndyvdyobgtlpeh4rho7pywpi 257 1 1 1 LS work_arndyvdyobgtlpeh4rho7pywpi 257 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 257 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 257 4 and and CC work_arndyvdyobgtlpeh4rho7pywpi 257 5 therefore therefore RB work_arndyvdyobgtlpeh4rho7pywpi 257 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 257 7 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 257 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 257 9 biotinylated biotinylate VBN work_arndyvdyobgtlpeh4rho7pywpi 257 10 mutant mutant JJ work_arndyvdyobgtlpeh4rho7pywpi 257 11 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 257 12 almost almost RB work_arndyvdyobgtlpeh4rho7pywpi 257 13 certainly certainly RB work_arndyvdyobgtlpeh4rho7pywpi 257 14 reflects reflect VBZ work_arndyvdyobgtlpeh4rho7pywpi 257 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 257 16 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 257 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 257 18 the the DT work_arndyvdyobgtlpeh4rho7pywpi 257 19 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 257 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 257 21 rather rather RB work_arndyvdyobgtlpeh4rho7pywpi 257 22 than than IN work_arndyvdyobgtlpeh4rho7pywpi 257 23 an an DT work_arndyvdyobgtlpeh4rho7pywpi 257 24 impairment impairment NN work_arndyvdyobgtlpeh4rho7pywpi 257 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 257 26 biotinylation biotinylation NN work_arndyvdyobgtlpeh4rho7pywpi 257 27 . . . work_arndyvdyobgtlpeh4rho7pywpi 258 1 With with IN work_arndyvdyobgtlpeh4rho7pywpi 258 2 regard regard NN work_arndyvdyobgtlpeh4rho7pywpi 258 3 to to IN work_arndyvdyobgtlpeh4rho7pywpi 258 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 258 5 efficiency efficiency NN work_arndyvdyobgtlpeh4rho7pywpi 258 6 of of IN work_arndyvdyobgtlpeh4rho7pywpi 258 7 RT- RT- NNP work_arndyvdyobgtlpeh4rho7pywpi 258 8 PCR PCR NNP work_arndyvdyobgtlpeh4rho7pywpi 258 9 amplification amplification NN work_arndyvdyobgtlpeh4rho7pywpi 258 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 258 11 we -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 258 12 noticed notice VBD work_arndyvdyobgtlpeh4rho7pywpi 258 13 no no DT work_arndyvdyobgtlpeh4rho7pywpi 258 14 differences difference NNS work_arndyvdyobgtlpeh4rho7pywpi 258 15 between between IN work_arndyvdyobgtlpeh4rho7pywpi 258 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 258 17 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 258 18 transcript transcript NN work_arndyvdyobgtlpeh4rho7pywpi 258 19 from from IN work_arndyvdyobgtlpeh4rho7pywpi 258 20 M325R M325R NNP work_arndyvdyobgtlpeh4rho7pywpi 258 21 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 258 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 258 23 that that IN work_arndyvdyobgtlpeh4rho7pywpi 258 24 from from IN work_arndyvdyobgtlpeh4rho7pywpi 258 25 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 258 26 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 258 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 258 28 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 258 29 would would MD work_arndyvdyobgtlpeh4rho7pywpi 258 30 suggest suggest VB work_arndyvdyobgtlpeh4rho7pywpi 258 31 both both DT work_arndyvdyobgtlpeh4rho7pywpi 258 32 that that IN work_arndyvdyobgtlpeh4rho7pywpi 258 33 this this DT work_arndyvdyobgtlpeh4rho7pywpi 258 34 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 258 35 does do VBZ work_arndyvdyobgtlpeh4rho7pywpi 258 36 not not RB work_arndyvdyobgtlpeh4rho7pywpi 258 37 result result VB work_arndyvdyobgtlpeh4rho7pywpi 258 38 in in IN work_arndyvdyobgtlpeh4rho7pywpi 258 39 mRNA mRNA NNP work_arndyvdyobgtlpeh4rho7pywpi 258 40 destabilization destabilization NN work_arndyvdyobgtlpeh4rho7pywpi 258 41 and and CC work_arndyvdyobgtlpeh4rho7pywpi 258 42 that that IN work_arndyvdyobgtlpeh4rho7pywpi 258 43 the the DT work_arndyvdyobgtlpeh4rho7pywpi 258 44 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 258 45 of of IN work_arndyvdyobgtlpeh4rho7pywpi 258 46 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 258 47 labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 258 48 possibly possibly RB work_arndyvdyobgtlpeh4rho7pywpi 258 49 results result VBZ work_arndyvdyobgtlpeh4rho7pywpi 258 50 from from IN work_arndyvdyobgtlpeh4rho7pywpi 258 51 decreased decreased JJ work_arndyvdyobgtlpeh4rho7pywpi 258 52 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 258 53 stability stability NN work_arndyvdyobgtlpeh4rho7pywpi 258 54 . . . work_arndyvdyobgtlpeh4rho7pywpi 259 1 Only only RB work_arndyvdyobgtlpeh4rho7pywpi 259 2 two two CD work_arndyvdyobgtlpeh4rho7pywpi 259 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 259 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 259 5 probands proband NNS work_arndyvdyobgtlpeh4rho7pywpi 259 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 259 7 the the DT work_arndyvdyobgtlpeh4rho7pywpi 259 8 present present JJ work_arndyvdyobgtlpeh4rho7pywpi 259 9 study study NN work_arndyvdyobgtlpeh4rho7pywpi 259 10 carry carry VBP work_arndyvdyobgtlpeh4rho7pywpi 259 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 259 12 same same JJ work_arndyvdyobgtlpeh4rho7pywpi 259 13 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 259 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 259 15 D172fs D172fs NNP work_arndyvdyobgtlpeh4rho7pywpi 259 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 259 17 . . . work_arndyvdyobgtlpeh4rho7pywpi 260 1 These these DT work_arndyvdyobgtlpeh4rho7pywpi 260 2 individuals individual NNS work_arndyvdyobgtlpeh4rho7pywpi 260 3 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 260 4 fe- fe- CD work_arndyvdyobgtlpeh4rho7pywpi 260 5 male male JJ work_arndyvdyobgtlpeh4rho7pywpi 260 6 adults adult NNS work_arndyvdyobgtlpeh4rho7pywpi 260 7 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 260 8 to to TO work_arndyvdyobgtlpeh4rho7pywpi 260 9 be be VB work_arndyvdyobgtlpeh4rho7pywpi 260 10 deficient deficient JJ work_arndyvdyobgtlpeh4rho7pywpi 260 11 for for IN work_arndyvdyobgtlpeh4rho7pywpi 260 12 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 260 13 but but CC work_arndyvdyobgtlpeh4rho7pywpi 260 14 clinically clinically RB work_arndyvdyobgtlpeh4rho7pywpi 260 15 asymptomatic asymptomatic JJ work_arndyvdyobgtlpeh4rho7pywpi 260 16 at at IN work_arndyvdyobgtlpeh4rho7pywpi 260 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 260 18 moment moment NN work_arndyvdyobgtlpeh4rho7pywpi 260 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 260 20 diagnosis diagnosis NN work_arndyvdyobgtlpeh4rho7pywpi 260 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 260 22 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 260 23 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 260 24 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 260 25 . . . work_arndyvdyobgtlpeh4rho7pywpi 261 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 261 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 261 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 262 1 They -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 262 2 belong belong VBP work_arndyvdyobgtlpeh4rho7pywpi 262 3 to to IN work_arndyvdyobgtlpeh4rho7pywpi 262 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 262 5 Amish Amish NNP work_arndyvdyobgtlpeh4rho7pywpi 262 6 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 262 7 Mennonite Mennonite NNP work_arndyvdyobgtlpeh4rho7pywpi 262 8 pop- pop- NNS work_arndyvdyobgtlpeh4rho7pywpi 262 9 ulation ulation NN work_arndyvdyobgtlpeh4rho7pywpi 262 10 and and CC work_arndyvdyobgtlpeh4rho7pywpi 262 11 came come VBD work_arndyvdyobgtlpeh4rho7pywpi 262 12 to to IN work_arndyvdyobgtlpeh4rho7pywpi 262 13 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 262 14 attention attention NN work_arndyvdyobgtlpeh4rho7pywpi 262 15 because because IN work_arndyvdyobgtlpeh4rho7pywpi 262 16 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 262 17 chil- chil- NN work_arndyvdyobgtlpeh4rho7pywpi 262 18 344 344 CD work_arndyvdyobgtlpeh4rho7pywpi 262 19 Am Am NNP work_arndyvdyobgtlpeh4rho7pywpi 262 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 263 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 263 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 263 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 264 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 264 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 265 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 265 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 265 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 265 4 Figure figure NN work_arndyvdyobgtlpeh4rho7pywpi 265 5 6 6 CD work_arndyvdyobgtlpeh4rho7pywpi 265 6 Knockout Knockout NNPS work_arndyvdyobgtlpeh4rho7pywpi 265 7 of of IN work_arndyvdyobgtlpeh4rho7pywpi 265 8 the the DT work_arndyvdyobgtlpeh4rho7pywpi 265 9 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 265 10 for for IN work_arndyvdyobgtlpeh4rho7pywpi 265 11 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 265 12 in in IN work_arndyvdyobgtlpeh4rho7pywpi 265 13 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 265 14 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 265 15 . . . work_arndyvdyobgtlpeh4rho7pywpi 266 1 An an DT work_arndyvdyobgtlpeh4rho7pywpi 266 2 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 266 3 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 266 4 DmccA DmccA NNP work_arndyvdyobgtlpeh4rho7pywpi 266 5 strain strain NN work_arndyvdyobgtlpeh4rho7pywpi 266 6 carrying carry VBG work_arndyvdyobgtlpeh4rho7pywpi 266 7 a a DT work_arndyvdyobgtlpeh4rho7pywpi 266 8 complete complete JJ work_arndyvdyobgtlpeh4rho7pywpi 266 9 deletion deletion NN work_arndyvdyobgtlpeh4rho7pywpi 266 10 of of IN work_arndyvdyobgtlpeh4rho7pywpi 266 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 266 12 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 266 13 encoding encode VBG work_arndyvdyobgtlpeh4rho7pywpi 266 14 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 266 15 MCCa MCCa NNS work_arndyvdyobgtlpeh4rho7pywpi 266 16 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 266 17 unable unable JJ work_arndyvdyobgtlpeh4rho7pywpi 266 18 to to TO work_arndyvdyobgtlpeh4rho7pywpi 266 19 utilize utilize VB work_arndyvdyobgtlpeh4rho7pywpi 266 20 leucine leucine NN work_arndyvdyobgtlpeh4rho7pywpi 266 21 as as IN work_arndyvdyobgtlpeh4rho7pywpi 266 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 266 23 sole sole JJ work_arndyvdyobgtlpeh4rho7pywpi 266 24 carbon carbon NN work_arndyvdyobgtlpeh4rho7pywpi 266 25 source source NN work_arndyvdyobgtlpeh4rho7pywpi 266 26 but but CC work_arndyvdyobgtlpeh4rho7pywpi 266 27 grows grow VBZ work_arndyvdyobgtlpeh4rho7pywpi 266 28 on on IN work_arndyvdyobgtlpeh4rho7pywpi 266 29 other other JJ work_arndyvdyobgtlpeh4rho7pywpi 266 30 branched branched JJ work_arndyvdyobgtlpeh4rho7pywpi 266 31 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 266 32 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 266 33 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 266 34 acids acid NNS work_arndyvdyobgtlpeh4rho7pywpi 266 35 . . . work_arndyvdyobgtlpeh4rho7pywpi 267 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 267 2 parental parental JJ work_arndyvdyobgtlpeh4rho7pywpi 267 3 strain strain NN work_arndyvdyobgtlpeh4rho7pywpi 267 4 and and CC work_arndyvdyobgtlpeh4rho7pywpi 267 5 three three CD work_arndyvdyobgtlpeh4rho7pywpi 267 6 independent independent JJ work_arndyvdyobgtlpeh4rho7pywpi 267 7 transformants transformant NNS work_arndyvdyobgtlpeh4rho7pywpi 267 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 267 9 denoted denote VBN work_arndyvdyobgtlpeh4rho7pywpi 267 10 “ " `` work_arndyvdyobgtlpeh4rho7pywpi 267 11 # # $ work_arndyvdyobgtlpeh4rho7pywpi 267 12 1”–“#3 1”–“#3 CD work_arndyvdyobgtlpeh4rho7pywpi 267 13 ” " '' work_arndyvdyobgtlpeh4rho7pywpi 267 14 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 267 15 deleted delete VBN work_arndyvdyobgtlpeh4rho7pywpi 267 16 for for IN work_arndyvdyobgtlpeh4rho7pywpi 267 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 267 18 mccA mccA NNS work_arndyvdyobgtlpeh4rho7pywpi 267 19 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 267 20 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 267 21 grown grow VBN work_arndyvdyobgtlpeh4rho7pywpi 267 22 on on IN work_arndyvdyobgtlpeh4rho7pywpi 267 23 synthetic synthetic JJ work_arndyvdyobgtlpeh4rho7pywpi 267 24 minimal minimal JJ work_arndyvdyobgtlpeh4rho7pywpi 267 25 medium medium NN work_arndyvdyobgtlpeh4rho7pywpi 267 26 with with IN work_arndyvdyobgtlpeh4rho7pywpi 267 27 ammonium ammonium NN work_arndyvdyobgtlpeh4rho7pywpi 267 28 chloride chloride NN work_arndyvdyobgtlpeh4rho7pywpi 267 29 as as IN work_arndyvdyobgtlpeh4rho7pywpi 267 30 the the DT work_arndyvdyobgtlpeh4rho7pywpi 267 31 nitrogen nitrogen NN work_arndyvdyobgtlpeh4rho7pywpi 267 32 source source NN work_arndyvdyobgtlpeh4rho7pywpi 267 33 and and CC work_arndyvdyobgtlpeh4rho7pywpi 267 34 with with IN work_arndyvdyobgtlpeh4rho7pywpi 267 35 30 30 CD work_arndyvdyobgtlpeh4rho7pywpi 267 36 mM mm NN work_arndyvdyobgtlpeh4rho7pywpi 267 37 of of IN work_arndyvdyobgtlpeh4rho7pywpi 267 38 the the DT work_arndyvdyobgtlpeh4rho7pywpi 267 39 indicated indicate VBN work_arndyvdyobgtlpeh4rho7pywpi 267 40 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 267 41 acids acid NNS work_arndyvdyobgtlpeh4rho7pywpi 267 42 as as IN work_arndyvdyobgtlpeh4rho7pywpi 267 43 the the DT work_arndyvdyobgtlpeh4rho7pywpi 267 44 sole sole JJ work_arndyvdyobgtlpeh4rho7pywpi 267 45 carbon carbon NN work_arndyvdyobgtlpeh4rho7pywpi 267 46 source source NN work_arndyvdyobgtlpeh4rho7pywpi 267 47 . . . work_arndyvdyobgtlpeh4rho7pywpi 268 1 Plates plate NNS work_arndyvdyobgtlpeh4rho7pywpi 268 2 were be VBD work_arndyvdyobgtlpeh4rho7pywpi 268 3 incubated incubate VBN work_arndyvdyobgtlpeh4rho7pywpi 268 4 for for IN work_arndyvdyobgtlpeh4rho7pywpi 268 5 5 5 CD work_arndyvdyobgtlpeh4rho7pywpi 268 6 d d NN work_arndyvdyobgtlpeh4rho7pywpi 268 7 at at IN work_arndyvdyobgtlpeh4rho7pywpi 268 8 37 37 CD work_arndyvdyobgtlpeh4rho7pywpi 268 9 � � NNP work_arndyvdyobgtlpeh4rho7pywpi 268 10 C. C. NNP work_arndyvdyobgtlpeh4rho7pywpi 269 1 Fungi Fungi NNP work_arndyvdyobgtlpeh4rho7pywpi 269 2 can can MD work_arndyvdyobgtlpeh4rho7pywpi 269 3 synthesize synthesize VB work_arndyvdyobgtlpeh4rho7pywpi 269 4 carbohydrates carbohydrate NNS work_arndyvdyobgtlpeh4rho7pywpi 269 5 from from IN work_arndyvdyobgtlpeh4rho7pywpi 269 6 acetyl acetyl NN work_arndyvdyobgtlpeh4rho7pywpi 269 7 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 269 8 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 269 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 269 10 via via IN work_arndyvdyobgtlpeh4rho7pywpi 269 11 the the DT work_arndyvdyobgtlpeh4rho7pywpi 269 12 glyoxylate glyoxylate JJ work_arndyvdyobgtlpeh4rho7pywpi 269 13 cycle cycle NN work_arndyvdyobgtlpeh4rho7pywpi 269 14 — — : work_arndyvdyobgtlpeh4rho7pywpi 269 15 thereby thereby RB work_arndyvdyobgtlpeh4rho7pywpi 269 16 bypassing bypass VBG work_arndyvdyobgtlpeh4rho7pywpi 269 17 the the DT work_arndyvdyobgtlpeh4rho7pywpi 269 18 Krebs Krebs NNP work_arndyvdyobgtlpeh4rho7pywpi 269 19 cycle cycle NN work_arndyvdyobgtlpeh4rho7pywpi 269 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 269 21 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 269 22 leads lead VBZ work_arndyvdyobgtlpeh4rho7pywpi 269 23 to to TO work_arndyvdyobgtlpeh4rho7pywpi 269 24 complete complete VB work_arndyvdyobgtlpeh4rho7pywpi 269 25 oxidation oxidation NN work_arndyvdyobgtlpeh4rho7pywpi 269 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 269 27 acetyl acetyl NN work_arndyvdyobgtlpeh4rho7pywpi 269 28 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 269 29 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 269 30 to to IN work_arndyvdyobgtlpeh4rho7pywpi 269 31 CO2 CO2 NNP work_arndyvdyobgtlpeh4rho7pywpi 269 32 and and CC work_arndyvdyobgtlpeh4rho7pywpi 269 33 water water NN work_arndyvdyobgtlpeh4rho7pywpi 269 34 . . . work_arndyvdyobgtlpeh4rho7pywpi 270 1 dren dren NNP work_arndyvdyobgtlpeh4rho7pywpi 270 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 270 3 later later RB work_arndyvdyobgtlpeh4rho7pywpi 270 4 shown show VBN work_arndyvdyobgtlpeh4rho7pywpi 270 5 to to TO work_arndyvdyobgtlpeh4rho7pywpi 270 6 be be VB work_arndyvdyobgtlpeh4rho7pywpi 270 7 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 270 8 obligate obligate NN work_arndyvdyobgtlpeh4rho7pywpi 270 9 carriers carrier NNS work_arndyvdyobgtlpeh4rho7pywpi 270 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 270 11 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 270 12 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 270 13 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 270 14 . . . work_arndyvdyobgtlpeh4rho7pywpi 271 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 271 2 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 271 3 present present JJ work_arndyvdyobgtlpeh4rho7pywpi 271 4 study study NN work_arndyvdyobgtlpeh4rho7pywpi 271 5 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 271 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 271 7 showed show VBD work_arndyvdyobgtlpeh4rho7pywpi 271 8 increased increase VBN work_arndyvdyobgtlpeh4rho7pywpi 271 9 quantities quantity NNS work_arndyvdyobgtlpeh4rho7pywpi 271 10 of of IN work_arndyvdyobgtlpeh4rho7pywpi 271 11 5C 5c NN work_arndyvdyobgtlpeh4rho7pywpi 271 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 271 13 OH oh NN work_arndyvdyobgtlpeh4rho7pywpi 271 14 in in IN work_arndyvdyobgtlpeh4rho7pywpi 271 15 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 271 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 271 17 possibly possibly RB work_arndyvdyobgtlpeh4rho7pywpi 271 18 as as IN work_arndyvdyobgtlpeh4rho7pywpi 271 19 a a DT work_arndyvdyobgtlpeh4rho7pywpi 271 20 result result NN work_arndyvdyobgtlpeh4rho7pywpi 271 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 271 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 271 23 accu- accu- NN work_arndyvdyobgtlpeh4rho7pywpi 271 24 mulation mulation NN work_arndyvdyobgtlpeh4rho7pywpi 271 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 271 26 maternal maternal JJ work_arndyvdyobgtlpeh4rho7pywpi 271 27 5C 5c NN work_arndyvdyobgtlpeh4rho7pywpi 271 28 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 271 29 OH oh NN work_arndyvdyobgtlpeh4rho7pywpi 271 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 271 31 the the DT work_arndyvdyobgtlpeh4rho7pywpi 271 32 red red JJ work_arndyvdyobgtlpeh4rho7pywpi 271 33 cells cell NNS work_arndyvdyobgtlpeh4rho7pywpi 271 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 271 35 these these DT work_arndyvdyobgtlpeh4rho7pywpi 271 36 children child NNS work_arndyvdyobgtlpeh4rho7pywpi 271 37 during during IN work_arndyvdyobgtlpeh4rho7pywpi 271 38 pregnancy pregnancy NN work_arndyvdyobgtlpeh4rho7pywpi 271 39 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 271 40 Ranieri Ranieri NNP work_arndyvdyobgtlpeh4rho7pywpi 271 41 et et FW work_arndyvdyobgtlpeh4rho7pywpi 271 42 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 271 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 272 1 2000b 2000b LS work_arndyvdyobgtlpeh4rho7pywpi 272 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 272 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 273 1 The the DT work_arndyvdyobgtlpeh4rho7pywpi 273 2 absence absence NN work_arndyvdyobgtlpeh4rho7pywpi 273 3 of of IN work_arndyvdyobgtlpeh4rho7pywpi 273 4 symptoms symptom NNS work_arndyvdyobgtlpeh4rho7pywpi 273 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 273 6 these these DT work_arndyvdyobgtlpeh4rho7pywpi 273 7 Mennonite Mennonite NNP work_arndyvdyobgtlpeh4rho7pywpi 273 8 female female JJ work_arndyvdyobgtlpeh4rho7pywpi 273 9 adults adult NNS work_arndyvdyobgtlpeh4rho7pywpi 273 10 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 273 11 an an DT work_arndyvdyobgtlpeh4rho7pywpi 273 12 extreme extreme JJ work_arndyvdyobgtlpeh4rho7pywpi 273 13 example example NN work_arndyvdyobgtlpeh4rho7pywpi 273 14 of of IN work_arndyvdyobgtlpeh4rho7pywpi 273 15 the the DT work_arndyvdyobgtlpeh4rho7pywpi 273 16 variable variable JJ work_arndyvdyobgtlpeh4rho7pywpi 273 17 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 273 18 phenotype phenotype NN work_arndyvdyobgtlpeh4rho7pywpi 273 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 273 20 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 273 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 273 22 Sweetman Sweetman NNP work_arndyvdyobgtlpeh4rho7pywpi 273 23 and and CC work_arndyvdyobgtlpeh4rho7pywpi 273 24 Williams Williams NNP work_arndyvdyobgtlpeh4rho7pywpi 273 25 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 273 26 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 273 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 273 28 in in IN work_arndyvdyobgtlpeh4rho7pywpi 273 29 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 273 30 the the DT work_arndyvdyobgtlpeh4rho7pywpi 273 31 symptoms symptom NNS work_arndyvdyobgtlpeh4rho7pywpi 273 32 range range VBP work_arndyvdyobgtlpeh4rho7pywpi 273 33 from from IN work_arndyvdyobgtlpeh4rho7pywpi 273 34 mild mild JJ work_arndyvdyobgtlpeh4rho7pywpi 273 35 muscular muscular JJ work_arndyvdyobgtlpeh4rho7pywpi 273 36 weakness weakness NN work_arndyvdyobgtlpeh4rho7pywpi 273 37 to to IN work_arndyvdyobgtlpeh4rho7pywpi 273 38 severe severe JJ work_arndyvdyobgtlpeh4rho7pywpi 273 39 episodes episode NNS work_arndyvdyobgtlpeh4rho7pywpi 273 40 of of IN work_arndyvdyobgtlpeh4rho7pywpi 273 41 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 273 42 decompensation decompensation NN work_arndyvdyobgtlpeh4rho7pywpi 273 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 274 1 It -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 274 2 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 274 3 noteworthy noteworthy JJ work_arndyvdyobgtlpeh4rho7pywpi 274 4 that that IN work_arndyvdyobgtlpeh4rho7pywpi 274 5 these these DT work_arndyvdyobgtlpeh4rho7pywpi 274 6 two two CD work_arndyvdyobgtlpeh4rho7pywpi 274 7 clinically clinically RB work_arndyvdyobgtlpeh4rho7pywpi 274 8 asymptomatic asymptomatic JJ work_arndyvdyobgtlpeh4rho7pywpi 274 9 female female JJ work_arndyvdyobgtlpeh4rho7pywpi 274 10 adults adult NNS work_arndyvdyobgtlpeh4rho7pywpi 274 11 carry carry VBP work_arndyvdyobgtlpeh4rho7pywpi 274 12 an an DT work_arndyvdyobgtlpeh4rho7pywpi 274 13 MCCb MCCb NNS work_arndyvdyobgtlpeh4rho7pywpi 274 14 null null NN work_arndyvdyobgtlpeh4rho7pywpi 274 15 mutation mutation NN work_arndyvdyobgtlpeh4rho7pywpi 274 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 274 17 apparently apparently RB work_arndyvdyobgtlpeh4rho7pywpi 274 18 in in IN work_arndyvdyobgtlpeh4rho7pywpi 274 19 homozy- homozy- NNP work_arndyvdyobgtlpeh4rho7pywpi 274 20 gosis gosis NN work_arndyvdyobgtlpeh4rho7pywpi 274 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 274 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 274 23 show show VBP work_arndyvdyobgtlpeh4rho7pywpi 274 24 highly highly RB work_arndyvdyobgtlpeh4rho7pywpi 274 25 elevated elevated JJ work_arndyvdyobgtlpeh4rho7pywpi 274 26 levels level NNS work_arndyvdyobgtlpeh4rho7pywpi 274 27 of of IN work_arndyvdyobgtlpeh4rho7pywpi 274 28 5C 5c NN work_arndyvdyobgtlpeh4rho7pywpi 274 29 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 274 30 OH oh NN work_arndyvdyobgtlpeh4rho7pywpi 274 31 and and CC work_arndyvdyobgtlpeh4rho7pywpi 274 32 3-methylcrotonylglycine 3-methylcrotonylglycine CD work_arndyvdyobgtlpeh4rho7pywpi 274 33 , , , work_arndyvdyobgtlpeh4rho7pywpi 274 34 in in IN work_arndyvdyobgtlpeh4rho7pywpi 274 35 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 274 36 and and CC work_arndyvdyobgtlpeh4rho7pywpi 274 37 urine urine NN work_arndyvdyobgtlpeh4rho7pywpi 274 38 , , , work_arndyvdyobgtlpeh4rho7pywpi 274 39 respec- respec- VBG work_arndyvdyobgtlpeh4rho7pywpi 274 40 tively tively RB work_arndyvdyobgtlpeh4rho7pywpi 274 41 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 274 42 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 274 43 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 274 44 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 274 45 . . . work_arndyvdyobgtlpeh4rho7pywpi 275 1 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 275 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 275 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 275 4 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 275 5 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 275 6 consistent consistent JJ work_arndyvdyobgtlpeh4rho7pywpi 275 7 with with IN work_arndyvdyobgtlpeh4rho7pywpi 275 8 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 275 9 genotype genotype NN work_arndyvdyobgtlpeh4rho7pywpi 275 10 . . . work_arndyvdyobgtlpeh4rho7pywpi 276 1 This this DT work_arndyvdyobgtlpeh4rho7pywpi 276 2 shows show VBZ work_arndyvdyobgtlpeh4rho7pywpi 276 3 the the DT work_arndyvdyobgtlpeh4rho7pywpi 276 4 significant significant JJ work_arndyvdyobgtlpeh4rho7pywpi 276 5 influence influence NN work_arndyvdyobgtlpeh4rho7pywpi 276 6 that that WDT work_arndyvdyobgtlpeh4rho7pywpi 276 7 en- en- XX work_arndyvdyobgtlpeh4rho7pywpi 276 8 vironmental vironmental JJ work_arndyvdyobgtlpeh4rho7pywpi 276 9 factors factor NNS work_arndyvdyobgtlpeh4rho7pywpi 276 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 276 11 such such JJ work_arndyvdyobgtlpeh4rho7pywpi 276 12 as as IN work_arndyvdyobgtlpeh4rho7pywpi 276 13 minor minor JJ work_arndyvdyobgtlpeh4rho7pywpi 276 14 intercurrent intercurrent NN work_arndyvdyobgtlpeh4rho7pywpi 276 15 infec- infec- NN work_arndyvdyobgtlpeh4rho7pywpi 276 16 tions tion NNS work_arndyvdyobgtlpeh4rho7pywpi 276 17 or or CC work_arndyvdyobgtlpeh4rho7pywpi 276 18 adoption adoption NN work_arndyvdyobgtlpeh4rho7pywpi 276 19 of of IN work_arndyvdyobgtlpeh4rho7pywpi 276 20 a a DT work_arndyvdyobgtlpeh4rho7pywpi 276 21 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 276 22 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 276 23 rich rich JJ work_arndyvdyobgtlpeh4rho7pywpi 276 24 diet diet NN work_arndyvdyobgtlpeh4rho7pywpi 276 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 276 26 which which WDT work_arndyvdyobgtlpeh4rho7pywpi 276 27 fre- fre- VBD work_arndyvdyobgtlpeh4rho7pywpi 276 28 quently quently RB work_arndyvdyobgtlpeh4rho7pywpi 276 29 trigger trigger VBP work_arndyvdyobgtlpeh4rho7pywpi 276 30 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 276 31 crises crisis NNS work_arndyvdyobgtlpeh4rho7pywpi 276 32 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 276 33 and/or and/or CC work_arndyvdyobgtlpeh4rho7pywpi 276 34 genetic genetic JJ work_arndyvdyobgtlpeh4rho7pywpi 276 35 makeup makeup NN work_arndyvdyobgtlpeh4rho7pywpi 276 36 may may MD work_arndyvdyobgtlpeh4rho7pywpi 276 37 have have VB work_arndyvdyobgtlpeh4rho7pywpi 276 38 in in IN work_arndyvdyobgtlpeh4rho7pywpi 276 39 the the DT work_arndyvdyobgtlpeh4rho7pywpi 276 40 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 276 41 outcome outcome NN work_arndyvdyobgtlpeh4rho7pywpi 276 42 of of IN work_arndyvdyobgtlpeh4rho7pywpi 276 43 this this DT work_arndyvdyobgtlpeh4rho7pywpi 276 44 potentially potentially RB work_arndyvdyobgtlpeh4rho7pywpi 276 45 severe severe JJ work_arndyvdyobgtlpeh4rho7pywpi 276 46 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 276 47 . . . work_arndyvdyobgtlpeh4rho7pywpi 277 1 Therefore therefore RB work_arndyvdyobgtlpeh4rho7pywpi 277 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 277 3 in in IN work_arndyvdyobgtlpeh4rho7pywpi 277 4 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 277 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 277 6 as as IN work_arndyvdyobgtlpeh4rho7pywpi 277 7 in in IN work_arndyvdyobgtlpeh4rho7pywpi 277 8 other other JJ work_arndyvdyobgtlpeh4rho7pywpi 277 9 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 277 10 monogenic monogenic JJ work_arndyvdyobgtlpeh4rho7pywpi 277 11 traits trait NNS work_arndyvdyobgtlpeh4rho7pywpi 277 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 277 13 the the DT work_arndyvdyobgtlpeh4rho7pywpi 277 14 enzyme enzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 277 15 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 277 16 structural structural JJ work_arndyvdyobgtlpeh4rho7pywpi 277 17 gene(s gene(s NNP work_arndyvdyobgtlpeh4rho7pywpi 277 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 277 19 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 277 20 the the DT work_arndyvdyobgtlpeh4rho7pywpi 277 21 major major JJ work_arndyvdyobgtlpeh4rho7pywpi 277 22 determinant determinant NN work_arndyvdyobgtlpeh4rho7pywpi 277 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 277 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 277 25 biochemical biochemical JJ work_arndyvdyobgtlpeh4rho7pywpi 277 26 phenotype phenotype NN work_arndyvdyobgtlpeh4rho7pywpi 277 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 277 28 but but CC work_arndyvdyobgtlpeh4rho7pywpi 277 29 the the DT work_arndyvdyobgtlpeh4rho7pywpi 277 30 associated associated NNP work_arndyvdyobgtlpeh4rho7pywpi 277 31 clinical clinical JJ work_arndyvdyobgtlpeh4rho7pywpi 277 32 features feature NNS work_arndyvdyobgtlpeh4rho7pywpi 277 33 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 277 34 complex complex JJ work_arndyvdyobgtlpeh4rho7pywpi 277 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 277 36 somehow somehow RB work_arndyvdyobgtlpeh4rho7pywpi 277 37 resembling resemble VBG work_arndyvdyobgtlpeh4rho7pywpi 277 38 the the DT work_arndyvdyobgtlpeh4rho7pywpi 277 39 so so RB work_arndyvdyobgtlpeh4rho7pywpi 277 40 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 277 41 called call VBN work_arndyvdyobgtlpeh4rho7pywpi 277 42 complex complex JJ work_arndyvdyobgtlpeh4rho7pywpi 277 43 traits trait NNS work_arndyvdyobgtlpeh4rho7pywpi 277 44 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 277 45 Scriver Scriver NNP work_arndyvdyobgtlpeh4rho7pywpi 277 46 and and CC work_arndyvdyobgtlpeh4rho7pywpi 277 47 Wa- Wa- NNP work_arndyvdyobgtlpeh4rho7pywpi 277 48 ters ter NNS work_arndyvdyobgtlpeh4rho7pywpi 277 49 1999 1999 CD work_arndyvdyobgtlpeh4rho7pywpi 277 50 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 277 51 . . . work_arndyvdyobgtlpeh4rho7pywpi 278 1 Although although IN work_arndyvdyobgtlpeh4rho7pywpi 278 2 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 278 3 previously previously RB work_arndyvdyobgtlpeh4rho7pywpi 278 4 had have VBD work_arndyvdyobgtlpeh4rho7pywpi 278 5 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 278 6 thought think VBN work_arndyvdyobgtlpeh4rho7pywpi 278 7 to to TO work_arndyvdyobgtlpeh4rho7pywpi 278 8 be be VB work_arndyvdyobgtlpeh4rho7pywpi 278 9 a a DT work_arndyvdyobgtlpeh4rho7pywpi 278 10 rare rare JJ work_arndyvdyobgtlpeh4rho7pywpi 278 11 inborn inborn NN work_arndyvdyobgtlpeh4rho7pywpi 278 12 error error NN work_arndyvdyobgtlpeh4rho7pywpi 278 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 278 14 metabolism metabolism NN work_arndyvdyobgtlpeh4rho7pywpi 278 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 278 16 the the DT work_arndyvdyobgtlpeh4rho7pywpi 278 17 introduction introduction NN work_arndyvdyobgtlpeh4rho7pywpi 278 18 of of IN work_arndyvdyobgtlpeh4rho7pywpi 278 19 massive massive JJ work_arndyvdyobgtlpeh4rho7pywpi 278 20 neonatal neonatal JJ work_arndyvdyobgtlpeh4rho7pywpi 278 21 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 278 22 by by IN work_arndyvdyobgtlpeh4rho7pywpi 278 23 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 278 24 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 278 25 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 278 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 278 27 urine urine NN work_arndyvdyobgtlpeh4rho7pywpi 278 28 or or CC work_arndyvdyobgtlpeh4rho7pywpi 278 29 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 278 30 spots spot NNS work_arndyvdyobgtlpeh4rho7pywpi 278 31 in in IN work_arndyvdyobgtlpeh4rho7pywpi 278 32 neonates neonate NNS work_arndyvdyobgtlpeh4rho7pywpi 278 33 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 278 34 revealed reveal VBN work_arndyvdyobgtlpeh4rho7pywpi 278 35 that that IN work_arndyvdyobgtlpeh4rho7pywpi 278 36 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 278 37 is be VBZ work_arndyvdyobgtlpeh4rho7pywpi 278 38 unexpect- unexpect- JJ work_arndyvdyobgtlpeh4rho7pywpi 278 39 edly edly RB work_arndyvdyobgtlpeh4rho7pywpi 278 40 frequent frequent JJ work_arndyvdyobgtlpeh4rho7pywpi 278 41 , , , work_arndyvdyobgtlpeh4rho7pywpi 278 42 with with IN work_arndyvdyobgtlpeh4rho7pywpi 278 43 an an DT work_arndyvdyobgtlpeh4rho7pywpi 278 44 incidence incidence NN work_arndyvdyobgtlpeh4rho7pywpi 278 45 , , , work_arndyvdyobgtlpeh4rho7pywpi 278 46 for for IN work_arndyvdyobgtlpeh4rho7pywpi 278 47 example example NN work_arndyvdyobgtlpeh4rho7pywpi 278 48 , , , work_arndyvdyobgtlpeh4rho7pywpi 278 49 of of IN work_arndyvdyobgtlpeh4rho7pywpi 278 50 ∼1/ ∼1/ CD work_arndyvdyobgtlpeh4rho7pywpi 278 51 27,000 27,000 CD work_arndyvdyobgtlpeh4rho7pywpi 278 52 in in IN work_arndyvdyobgtlpeh4rho7pywpi 278 53 South South NNP work_arndyvdyobgtlpeh4rho7pywpi 278 54 Australia Australia NNP work_arndyvdyobgtlpeh4rho7pywpi 278 55 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 278 56 Ranieri Ranieri NNP work_arndyvdyobgtlpeh4rho7pywpi 278 57 et et FW work_arndyvdyobgtlpeh4rho7pywpi 278 58 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 278 59 . . . work_arndyvdyobgtlpeh4rho7pywpi 279 1 2000a 2000a LS work_arndyvdyobgtlpeh4rho7pywpi 279 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 279 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 279 4 ∼1/ ∼1/ NNP work_arndyvdyobgtlpeh4rho7pywpi 279 5 52,000 52,000 CD work_arndyvdyobgtlpeh4rho7pywpi 279 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 279 7 North North NNP work_arndyvdyobgtlpeh4rho7pywpi 279 8 Carolina Carolina NNP work_arndyvdyobgtlpeh4rho7pywpi 279 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 279 10 Smith Smith NNP work_arndyvdyobgtlpeh4rho7pywpi 279 11 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 279 12 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 279 13 . . . work_arndyvdyobgtlpeh4rho7pywpi 280 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 280 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 280 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 280 4 ∼1/ ∼1/ NNP work_arndyvdyobgtlpeh4rho7pywpi 280 5 110,000 110,000 CD work_arndyvdyobgtlpeh4rho7pywpi 280 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 280 7 New New NNP work_arndyvdyobgtlpeh4rho7pywpi 280 8 South South NNP work_arndyvdyobgtlpeh4rho7pywpi 280 9 Wales Wales NNP work_arndyvdyobgtlpeh4rho7pywpi 280 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 280 11 Wilcken Wilcken NNP work_arndyvdyobgtlpeh4rho7pywpi 280 12 et et FW work_arndyvdyobgtlpeh4rho7pywpi 280 13 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 280 14 . . . work_arndyvdyobgtlpeh4rho7pywpi 281 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 281 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 281 3 , , , work_arndyvdyobgtlpeh4rho7pywpi 281 4 and and CC work_arndyvdyobgtlpeh4rho7pywpi 281 5 ∼1/30,000 ∼1/30,000 NNP work_arndyvdyobgtlpeh4rho7pywpi 281 6 in in IN work_arndyvdyobgtlpeh4rho7pywpi 281 7 Bavaria Bavaria NNP work_arndyvdyobgtlpeh4rho7pywpi 281 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 281 9 where where WRB work_arndyvdyobgtlpeh4rho7pywpi 281 10 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 281 11 appears appear VBZ work_arndyvdyobgtlpeh4rho7pywpi 281 12 to to TO work_arndyvdyobgtlpeh4rho7pywpi 281 13 be be VB work_arndyvdyobgtlpeh4rho7pywpi 281 14 the the DT work_arndyvdyobgtlpeh4rho7pywpi 281 15 most most RBS work_arndyvdyobgtlpeh4rho7pywpi 281 16 frequent frequent JJ work_arndyvdyobgtlpeh4rho7pywpi 281 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 281 18 the the DT work_arndyvdyobgtlpeh4rho7pywpi 281 19 organic organic JJ work_arndyvdyobgtlpeh4rho7pywpi 281 20 acidurias acidurias NNP work_arndyvdyobgtlpeh4rho7pywpi 281 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 281 22 Roscher Roscher NNP work_arndyvdyobgtlpeh4rho7pywpi 281 23 et et FW work_arndyvdyobgtlpeh4rho7pywpi 281 24 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 281 25 . . . work_arndyvdyobgtlpeh4rho7pywpi 282 1 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 282 2 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 282 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 283 1 Our -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 283 2 work work NN work_arndyvdyobgtlpeh4rho7pywpi 283 3 provides provide VBZ work_arndyvdyobgtlpeh4rho7pywpi 283 4 the the DT work_arndyvdyobgtlpeh4rho7pywpi 283 5 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 283 6 tools tool NNS work_arndyvdyobgtlpeh4rho7pywpi 283 7 to to TO work_arndyvdyobgtlpeh4rho7pywpi 283 8 an- an- CC work_arndyvdyobgtlpeh4rho7pywpi 283 9 alyze alyze VB work_arndyvdyobgtlpeh4rho7pywpi 283 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 283 11 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 283 12 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 283 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 283 14 this this DT work_arndyvdyobgtlpeh4rho7pywpi 283 15 emergent emergent JJ work_arndyvdyobgtlpeh4rho7pywpi 283 16 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 283 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 283 18 paves pave VBZ work_arndyvdyobgtlpeh4rho7pywpi 283 19 the the DT work_arndyvdyobgtlpeh4rho7pywpi 283 20 way way NN work_arndyvdyobgtlpeh4rho7pywpi 283 21 for for IN work_arndyvdyobgtlpeh4rho7pywpi 283 22 future future JJ work_arndyvdyobgtlpeh4rho7pywpi 283 23 studies study NNS work_arndyvdyobgtlpeh4rho7pywpi 283 24 on on IN work_arndyvdyobgtlpeh4rho7pywpi 283 25 phenotype phenotype NN work_arndyvdyobgtlpeh4rho7pywpi 283 26 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 283 27 genotype genotype NN work_arndyvdyobgtlpeh4rho7pywpi 283 28 cor- cor- NN work_arndyvdyobgtlpeh4rho7pywpi 283 29 relations relation NNS work_arndyvdyobgtlpeh4rho7pywpi 283 30 , , , work_arndyvdyobgtlpeh4rho7pywpi 283 31 and and CC work_arndyvdyobgtlpeh4rho7pywpi 283 32 should should MD work_arndyvdyobgtlpeh4rho7pywpi 283 33 facilitate facilitate VB work_arndyvdyobgtlpeh4rho7pywpi 283 34 the the DT work_arndyvdyobgtlpeh4rho7pywpi 283 35 detection detection NN work_arndyvdyobgtlpeh4rho7pywpi 283 36 of of IN work_arndyvdyobgtlpeh4rho7pywpi 283 37 hetero- hetero- JJ work_arndyvdyobgtlpeh4rho7pywpi 283 38 zygote zygote NN work_arndyvdyobgtlpeh4rho7pywpi 283 39 carriers carrier NNS work_arndyvdyobgtlpeh4rho7pywpi 283 40 and and CC work_arndyvdyobgtlpeh4rho7pywpi 283 41 false false JJ work_arndyvdyobgtlpeh4rho7pywpi 283 42 positives positive NNS work_arndyvdyobgtlpeh4rho7pywpi 283 43 of of IN work_arndyvdyobgtlpeh4rho7pywpi 283 44 neonatal neonatal NN work_arndyvdyobgtlpeh4rho7pywpi 283 45 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 283 46 . . . work_arndyvdyobgtlpeh4rho7pywpi 284 1 Finally finally RB work_arndyvdyobgtlpeh4rho7pywpi 284 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 284 3 this this DT work_arndyvdyobgtlpeh4rho7pywpi 284 4 work work NN work_arndyvdyobgtlpeh4rho7pywpi 284 5 completes complete VBZ work_arndyvdyobgtlpeh4rho7pywpi 284 6 the the DT work_arndyvdyobgtlpeh4rho7pywpi 284 7 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 284 8 of of IN work_arndyvdyobgtlpeh4rho7pywpi 284 9 all all DT work_arndyvdyobgtlpeh4rho7pywpi 284 10 four four CD work_arndyvdyobgtlpeh4rho7pywpi 284 11 biotin biotin NN work_arndyvdyobgtlpeh4rho7pywpi 284 12 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 284 13 dependent dependent JJ work_arndyvdyobgtlpeh4rho7pywpi 284 14 carboxylases carboxylase NNS work_arndyvdyobgtlpeh4rho7pywpi 284 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 284 16 human human NNP work_arndyvdyobgtlpeh4rho7pywpi 284 17 inter- inter- NNP work_arndyvdyobgtlpeh4rho7pywpi 284 18 mediary mediary NNP work_arndyvdyobgtlpeh4rho7pywpi 284 19 metabolism metabolism NNP work_arndyvdyobgtlpeh4rho7pywpi 284 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 285 1 Note note NN work_arndyvdyobgtlpeh4rho7pywpi 285 2 added add VBN work_arndyvdyobgtlpeh4rho7pywpi 285 3 in in IN work_arndyvdyobgtlpeh4rho7pywpi 285 4 proof.—We proof.—We NNP work_arndyvdyobgtlpeh4rho7pywpi 285 5 have have VBP work_arndyvdyobgtlpeh4rho7pywpi 285 6 recently recently RB work_arndyvdyobgtlpeh4rho7pywpi 285 7 learned learn VBN work_arndyvdyobgtlpeh4rho7pywpi 285 8 that that IN work_arndyvdyobgtlpeh4rho7pywpi 285 9 the the DT work_arndyvdyobgtlpeh4rho7pywpi 285 10 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 285 11 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 285 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 285 13 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 285 14 has have VBZ work_arndyvdyobgtlpeh4rho7pywpi 285 15 also also RB work_arndyvdyobgtlpeh4rho7pywpi 285 16 been be VBN work_arndyvdyobgtlpeh4rho7pywpi 285 17 identified identify VBN work_arndyvdyobgtlpeh4rho7pywpi 285 18 by by IN work_arndyvdyobgtlpeh4rho7pywpi 285 19 Baumgartner Baumgartner NNP work_arndyvdyobgtlpeh4rho7pywpi 285 20 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 285 21 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 285 22 . . . work_arndyvdyobgtlpeh4rho7pywpi 286 1 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 286 2 in in IN work_arndyvdyobgtlpeh4rho7pywpi 286 3 press press NN work_arndyvdyobgtlpeh4rho7pywpi 286 4 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 286 5 . . . work_arndyvdyobgtlpeh4rho7pywpi 287 1 Acknowledgments acknowledgment NNS work_arndyvdyobgtlpeh4rho7pywpi 287 2 We -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 287 3 thank thank VBP work_arndyvdyobgtlpeh4rho7pywpi 287 4 Herbert Herbert NNP work_arndyvdyobgtlpeh4rho7pywpi 287 5 N. N. NNP work_arndyvdyobgtlpeh4rho7pywpi 287 6 Arst Arst NNP work_arndyvdyobgtlpeh4rho7pywpi 287 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 287 8 for for IN work_arndyvdyobgtlpeh4rho7pywpi 287 9 critical critical JJ work_arndyvdyobgtlpeh4rho7pywpi 287 10 reading reading NN work_arndyvdyobgtlpeh4rho7pywpi 287 11 of of IN work_arndyvdyobgtlpeh4rho7pywpi 287 12 the the DT work_arndyvdyobgtlpeh4rho7pywpi 287 13 man- man- JJ work_arndyvdyobgtlpeh4rho7pywpi 287 14 uscript uscript NN work_arndyvdyobgtlpeh4rho7pywpi 287 15 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 287 16 R. R. NNP work_arndyvdyobgtlpeh4rho7pywpi 287 17 Navarrete Navarrete NNP work_arndyvdyobgtlpeh4rho7pywpi 287 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 287 19 E. E. NNP work_arndyvdyobgtlpeh4rho7pywpi 287 20 Reoyo Reoyo NNP work_arndyvdyobgtlpeh4rho7pywpi 287 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 287 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 287 23 staff staff NN work_arndyvdyobgtlpeh4rho7pywpi 287 24 in in IN work_arndyvdyobgtlpeh4rho7pywpi 287 25 the the DT work_arndyvdyobgtlpeh4rho7pywpi 287 26 sequencing sequencing NN work_arndyvdyobgtlpeh4rho7pywpi 287 27 Gallardo Gallardo NNP work_arndyvdyobgtlpeh4rho7pywpi 287 28 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 287 29 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 287 30 . . . work_arndyvdyobgtlpeh4rho7pywpi 288 1 : : : work_arndyvdyobgtlpeh4rho7pywpi 288 2 3-Methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 288 3 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 288 4 CoA coa NN work_arndyvdyobgtlpeh4rho7pywpi 288 5 Carboxylase Carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 288 6 Deficiency Deficiency NNP work_arndyvdyobgtlpeh4rho7pywpi 288 7 345 345 CD work_arndyvdyobgtlpeh4rho7pywpi 288 8 facility facility NN work_arndyvdyobgtlpeh4rho7pywpi 288 9 at at IN work_arndyvdyobgtlpeh4rho7pywpi 288 10 the the DT work_arndyvdyobgtlpeh4rho7pywpi 288 11 Centro Centro NNP work_arndyvdyobgtlpeh4rho7pywpi 288 12 de de IN work_arndyvdyobgtlpeh4rho7pywpi 288 13 Investigaciones Investigaciones NNP work_arndyvdyobgtlpeh4rho7pywpi 288 14 Biologı́cas Biologı́cas NNP work_arndyvdyobgtlpeh4rho7pywpi 288 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 288 16 for for IN work_arndyvdyobgtlpeh4rho7pywpi 288 17 tech- tech- JJ work_arndyvdyobgtlpeh4rho7pywpi 288 18 nical nical JJ work_arndyvdyobgtlpeh4rho7pywpi 288 19 assistance assistance NN work_arndyvdyobgtlpeh4rho7pywpi 288 20 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 288 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 288 22 Fundación Fundación NNP work_arndyvdyobgtlpeh4rho7pywpi 288 23 Ramón Ramón NNP work_arndyvdyobgtlpeh4rho7pywpi 288 24 Areces Areces NNPS work_arndyvdyobgtlpeh4rho7pywpi 288 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 288 26 for for IN work_arndyvdyobgtlpeh4rho7pywpi 288 27 an an DT work_arndyvdyobgtlpeh4rho7pywpi 288 28 insti- insti- FW work_arndyvdyobgtlpeh4rho7pywpi 288 29 tutional tutional JJ work_arndyvdyobgtlpeh4rho7pywpi 288 30 grant grant NN work_arndyvdyobgtlpeh4rho7pywpi 288 31 to to IN work_arndyvdyobgtlpeh4rho7pywpi 288 32 the the DT work_arndyvdyobgtlpeh4rho7pywpi 288 33 Centro Centro NNP work_arndyvdyobgtlpeh4rho7pywpi 288 34 de de IN work_arndyvdyobgtlpeh4rho7pywpi 288 35 Biologı́a Biologı́a NNP work_arndyvdyobgtlpeh4rho7pywpi 288 36 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 288 37 CSIC- CSIC- NNP work_arndyvdyobgtlpeh4rho7pywpi 288 38 UAM UAM NNP work_arndyvdyobgtlpeh4rho7pywpi 288 39 ; ; : work_arndyvdyobgtlpeh4rho7pywpi 288 40 and and CC work_arndyvdyobgtlpeh4rho7pywpi 288 41 the the DT work_arndyvdyobgtlpeh4rho7pywpi 288 42 Dirección Dirección NNP work_arndyvdyobgtlpeh4rho7pywpi 288 43 General General NNP work_arndyvdyobgtlpeh4rho7pywpi 288 44 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 288 45 Investigacion Investigacion NNP work_arndyvdyobgtlpeh4rho7pywpi 288 46 Cientifica Cientifica NNP work_arndyvdyobgtlpeh4rho7pywpi 288 47 y y NNP work_arndyvdyobgtlpeh4rho7pywpi 288 48 Técnica Técnica NNP work_arndyvdyobgtlpeh4rho7pywpi 288 49 , , , work_arndyvdyobgtlpeh4rho7pywpi 288 50 for for IN work_arndyvdyobgtlpeh4rho7pywpi 288 51 support support NN work_arndyvdyobgtlpeh4rho7pywpi 288 52 through through IN work_arndyvdyobgtlpeh4rho7pywpi 288 53 grant grant NNP work_arndyvdyobgtlpeh4rho7pywpi 288 54 2FD97 2FD97 NNP work_arndyvdyobgtlpeh4rho7pywpi 288 55 - - SYM work_arndyvdyobgtlpeh4rho7pywpi 288 56 1292 1292 CD work_arndyvdyobgtlpeh4rho7pywpi 288 57 . . . work_arndyvdyobgtlpeh4rho7pywpi 289 1 Electronic electronic JJ work_arndyvdyobgtlpeh4rho7pywpi 289 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 289 3 Database Database NNP work_arndyvdyobgtlpeh4rho7pywpi 289 4 Information Information NNP work_arndyvdyobgtlpeh4rho7pywpi 289 5 Accession Accession NNP work_arndyvdyobgtlpeh4rho7pywpi 289 6 numbers number NNS work_arndyvdyobgtlpeh4rho7pywpi 289 7 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 8 URLs url NNS work_arndyvdyobgtlpeh4rho7pywpi 289 9 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 10 data datum NNS work_arndyvdyobgtlpeh4rho7pywpi 289 11 in in IN work_arndyvdyobgtlpeh4rho7pywpi 289 12 this this DT work_arndyvdyobgtlpeh4rho7pywpi 289 13 article article NN work_arndyvdyobgtlpeh4rho7pywpi 289 14 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 289 15 as as IN work_arndyvdyobgtlpeh4rho7pywpi 289 16 follows follow VBZ work_arndyvdyobgtlpeh4rho7pywpi 289 17 : : : work_arndyvdyobgtlpeh4rho7pywpi 289 18 BLAST blast NN work_arndyvdyobgtlpeh4rho7pywpi 289 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 20 http://www.ncbi.nlm.nih.gov/BLAST/ http://www.ncbi.nlm.nih.gov/BLAST/ NNP work_arndyvdyobgtlpeh4rho7pywpi 289 21 Expressed express VBD work_arndyvdyobgtlpeh4rho7pywpi 289 22 Sequence Sequence NNP work_arndyvdyobgtlpeh4rho7pywpi 289 23 Tags Tags NNP work_arndyvdyobgtlpeh4rho7pywpi 289 24 database database NN work_arndyvdyobgtlpeh4rho7pywpi 289 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 26 http://www.ncbi.nlm.nih http://www.ncbi.nlm.nih ADD work_arndyvdyobgtlpeh4rho7pywpi 289 27 .gov .gov . work_arndyvdyobgtlpeh4rho7pywpi 289 28 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 29 dbEST dbest NN work_arndyvdyobgtlpeh4rho7pywpi 289 30 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 31 index.html index.html NNP work_arndyvdyobgtlpeh4rho7pywpi 289 32 Fungal Fungal NNP work_arndyvdyobgtlpeh4rho7pywpi 289 33 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 34 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 289 35 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 289 36 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 37 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 289 38 parasiticus parasiticus NN work_arndyvdyobgtlpeh4rho7pywpi 289 39 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 40 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 41 Neu- Neu- NNP work_arndyvdyobgtlpeh4rho7pywpi 289 42 rospora rospora NNP work_arndyvdyobgtlpeh4rho7pywpi 289 43 crassa crassa NNP work_arndyvdyobgtlpeh4rho7pywpi 289 44 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 45 Cosmid Cosmid NNP work_arndyvdyobgtlpeh4rho7pywpi 289 46 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 47 cDNA cdna VB work_arndyvdyobgtlpeh4rho7pywpi 289 48 Sequencing Sequencing NNP work_arndyvdyobgtlpeh4rho7pywpi 289 49 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 50 http://www http://www ADD work_arndyvdyobgtlpeh4rho7pywpi 289 51 .genome.ou.edu .genome.ou.edu . work_arndyvdyobgtlpeh4rho7pywpi 289 52 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 53 fungal.html fungal.html NNS work_arndyvdyobgtlpeh4rho7pywpi 289 54 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 55 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 56 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 289 57 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 289 58 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 59 ac- ac- RB work_arndyvdyobgtlpeh4rho7pywpi 289 60 cession cession NN work_arndyvdyobgtlpeh4rho7pywpi 289 61 number number NN work_arndyvdyobgtlpeh4rho7pywpi 289 62 n1c10 n1c10 XX work_arndyvdyobgtlpeh4rho7pywpi 289 63 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 64 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 65 Fungal Fungal NNP work_arndyvdyobgtlpeh4rho7pywpi 289 66 Genetics Genetics NNP work_arndyvdyobgtlpeh4rho7pywpi 289 67 Stock Stock NNP work_arndyvdyobgtlpeh4rho7pywpi 289 68 Center Center NNP work_arndyvdyobgtlpeh4rho7pywpi 289 69 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 70 http://www.fgsc.net/ http://www.fgsc.net/ NNP work_arndyvdyobgtlpeh4rho7pywpi 289 71 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 72 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 73 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 289 74 EST EST NNP work_arndyvdyobgtlpeh4rho7pywpi 289 75 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 289 76 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 77 GenBank GenBank NNP work_arndyvdyobgtlpeh4rho7pywpi 289 78 Overview Overview NNP work_arndyvdyobgtlpeh4rho7pywpi 289 79 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 80 http://www.ncbi.nlm.nih.gov/Genbank/ http://www.ncbi.nlm.nih.gov/Genbank/ NNP work_arndyvdyobgtlpeh4rho7pywpi 289 81 GenbankOverview.html GenbankOverview.html NNP work_arndyvdyobgtlpeh4rho7pywpi 289 82 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 83 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 84 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 85 MCCA mcca NN work_arndyvdyobgtlpeh4rho7pywpi 289 86 ESTs est NNS work_arndyvdyobgtlpeh4rho7pywpi 289 87 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 88 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 89 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 90 numbers number NNS work_arndyvdyobgtlpeh4rho7pywpi 289 91 AA134548 AA134548 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 92 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 93 AA605162 AA605162 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 94 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 95 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 96 AW410916 AW410916 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 97 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 98 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 99 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 100 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 289 101 ESTs ESTs NNP work_arndyvdyobgtlpeh4rho7pywpi 289 102 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 103 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 104 numbers number NNS work_arndyvdyobgtlpeh4rho7pywpi 289 105 AA465612 AA465612 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 106 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 107 AI949422 AI949422 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 108 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 109 AI367183 AI367183 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 110 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 111 AW439494 AW439494 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 112 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 113 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 114 AI869038 AI869038 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 115 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 116 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 117 full full JJ work_arndyvdyobgtlpeh4rho7pywpi 289 118 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 289 119 length length NN work_arndyvdyobgtlpeh4rho7pywpi 289 120 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 121 MCCA mcca NN work_arndyvdyobgtlpeh4rho7pywpi 289 122 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 289 123 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 124 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 125 number number NN work_arndyvdyobgtlpeh4rho7pywpi 289 126 AF310972 af310972 NN work_arndyvdyobgtlpeh4rho7pywpi 289 127 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 128 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 129 full full JJ work_arndyvdyobgtlpeh4rho7pywpi 289 130 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 289 131 length length NN work_arndyvdyobgtlpeh4rho7pywpi 289 132 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 289 133 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 289 134 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 135 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 136 number number NN work_arndyvdyobgtlpeh4rho7pywpi 289 137 AF310971 af310971 NN work_arndyvdyobgtlpeh4rho7pywpi 289 138 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 139 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 140 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 141 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 289 142 BAC BAC NNP work_arndyvdyobgtlpeh4rho7pywpi 289 143 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 144 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 145 number number NN work_arndyvdyobgtlpeh4rho7pywpi 289 146 AC026920 AC026920 . work_arndyvdyobgtlpeh4rho7pywpi 289 147 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 148 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 149 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 150 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 151 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 289 152 BACs bac NNS work_arndyvdyobgtlpeh4rho7pywpi 289 153 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 154 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 155 numbers number NNS work_arndyvdyobgtlpeh4rho7pywpi 289 156 AC010279 AC010279 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 157 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 158 AC026775 ac026775 UH work_arndyvdyobgtlpeh4rho7pywpi 289 159 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 160 and and CC work_arndyvdyobgtlpeh4rho7pywpi 289 161 AC025958 AC025958 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 162 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 163 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 164 GeneMap’99 GeneMap’99 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 165 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 166 http://www.ncbi.nlm.nih.gov/genemap99/ http://www.ncbi.nlm.nih.gov/genemap99/ NNP work_arndyvdyobgtlpeh4rho7pywpi 289 167 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 168 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 169 overview overview NN work_arndyvdyobgtlpeh4rho7pywpi 289 170 of of IN work_arndyvdyobgtlpeh4rho7pywpi 289 171 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 172 chromosome chromosome NN work_arndyvdyobgtlpeh4rho7pywpi 289 173 maps map NNS work_arndyvdyobgtlpeh4rho7pywpi 289 174 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 175 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 176 Unigene Unigene NNP work_arndyvdyobgtlpeh4rho7pywpi 289 177 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 289 178 cluster cluster NN work_arndyvdyobgtlpeh4rho7pywpi 289 179 H. H. NNP work_arndyvdyobgtlpeh4rho7pywpi 289 180 167531 167531 CD work_arndyvdyobgtlpeh4rho7pywpi 289 181 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 182 STS sts JJ work_arndyvdyobgtlpeh4rho7pywpi 289 183 accession accession NN work_arndyvdyobgtlpeh4rho7pywpi 289 184 number number NN work_arndyvdyobgtlpeh4rho7pywpi 289 185 SGC34463 SGC34463 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 186 or or CC work_arndyvdyobgtlpeh4rho7pywpi 289 187 SHGC-34463 SHGC-34463 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 188 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 189 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 190 Incyte Incyte NNP work_arndyvdyobgtlpeh4rho7pywpi 289 191 Genomics Genomics NNP work_arndyvdyobgtlpeh4rho7pywpi 289 192 http://www.incyte.com/ http://www.incyte.com/ NN work_arndyvdyobgtlpeh4rho7pywpi 289 193 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 194 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 195 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 196 EST est NN work_arndyvdyobgtlpeh4rho7pywpi 289 197 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 289 198 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 199 Online Online NNP work_arndyvdyobgtlpeh4rho7pywpi 289 200 Mendelian Mendelian NNP work_arndyvdyobgtlpeh4rho7pywpi 289 201 Inheritance Inheritance NNP work_arndyvdyobgtlpeh4rho7pywpi 289 202 in in IN work_arndyvdyobgtlpeh4rho7pywpi 289 203 Man Man NNP work_arndyvdyobgtlpeh4rho7pywpi 289 204 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 205 OMIM OMIM NNP work_arndyvdyobgtlpeh4rho7pywpi 289 206 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 207 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 208 http://www http://www ADD work_arndyvdyobgtlpeh4rho7pywpi 289 209 .ncbi.nlm.nih.gov .ncbi.nlm.nih.gov . work_arndyvdyobgtlpeh4rho7pywpi 289 210 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 211 Omim/ Omim/ NNP work_arndyvdyobgtlpeh4rho7pywpi 289 212 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 213 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 214 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 289 215 [ [ -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 216 MIM MIM NNP work_arndyvdyobgtlpeh4rho7pywpi 289 217 210200 210200 CD work_arndyvdyobgtlpeh4rho7pywpi 289 218 ] ] -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 219 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 220 Radiation Radiation NNP work_arndyvdyobgtlpeh4rho7pywpi 289 221 Hybrid Hybrid NNP work_arndyvdyobgtlpeh4rho7pywpi 289 222 Mapping Mapping NNP work_arndyvdyobgtlpeh4rho7pywpi 289 223 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 224 http://carbon.wi.mit.edu:8000/ http://carbon.wi.mit.edu:8000/ NNP work_arndyvdyobgtlpeh4rho7pywpi 289 225 cgi cgi NN work_arndyvdyobgtlpeh4rho7pywpi 289 226 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 289 227 bin bin NNP work_arndyvdyobgtlpeh4rho7pywpi 289 228 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 229 contig contig NNP work_arndyvdyobgtlpeh4rho7pywpi 289 230 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 231 rhmapper.pl rhmapper.pl NNP work_arndyvdyobgtlpeh4rho7pywpi 289 232 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 233 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 234 Genebridge Genebridge NNP work_arndyvdyobgtlpeh4rho7pywpi 289 235 4 4 CD work_arndyvdyobgtlpeh4rho7pywpi 289 236 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 289 237 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 238 Resource Resource NNP work_arndyvdyobgtlpeh4rho7pywpi 289 239 Center Center NNP work_arndyvdyobgtlpeh4rho7pywpi 289 240 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 241 Primary Primary NNP work_arndyvdyobgtlpeh4rho7pywpi 289 242 Database Database NNP work_arndyvdyobgtlpeh4rho7pywpi 289 243 RZPD RZPD NNP work_arndyvdyobgtlpeh4rho7pywpi 289 244 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 245 http://www.rzpd http://www.rzpd NNP work_arndyvdyobgtlpeh4rho7pywpi 289 246 .de/ .de/ . work_arndyvdyobgtlpeh4rho7pywpi 289 247 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 248 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 249 human human NNP work_arndyvdyobgtlpeh4rho7pywpi 289 250 PAC PAC NNP work_arndyvdyobgtlpeh4rho7pywpi 289 251 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 289 252 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 253 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 254 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 255 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 289 256 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 257 RPCI-4 RPCI-4 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 258 615H13 615h13 CD work_arndyvdyobgtlpeh4rho7pywpi 289 259 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 260 Stanford Stanford NNP work_arndyvdyobgtlpeh4rho7pywpi 289 261 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 289 262 Genome Genome NNP work_arndyvdyobgtlpeh4rho7pywpi 289 263 Center Center NNP work_arndyvdyobgtlpeh4rho7pywpi 289 264 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 265 http://shgc-www.stanford http://shgc-www.stanford NNP work_arndyvdyobgtlpeh4rho7pywpi 289 266 .edu .edu . work_arndyvdyobgtlpeh4rho7pywpi 289 267 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 268 RH RH NNP work_arndyvdyobgtlpeh4rho7pywpi 289 269 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 289 270 index.html index.html NNP work_arndyvdyobgtlpeh4rho7pywpi 289 271 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 289 272 for for IN work_arndyvdyobgtlpeh4rho7pywpi 289 273 G3 G3 NNP work_arndyvdyobgtlpeh4rho7pywpi 289 274 panel panel NN work_arndyvdyobgtlpeh4rho7pywpi 289 275 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 289 276 References References NNPS work_arndyvdyobgtlpeh4rho7pywpi 289 277 Baumgartner Baumgartner NNP work_arndyvdyobgtlpeh4rho7pywpi 289 278 MR MR NNP work_arndyvdyobgtlpeh4rho7pywpi 289 279 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 280 Almashanu Almashanu NNP work_arndyvdyobgtlpeh4rho7pywpi 289 281 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 289 282 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 283 Suormala Suormala NNP work_arndyvdyobgtlpeh4rho7pywpi 289 284 T T NNP work_arndyvdyobgtlpeh4rho7pywpi 289 285 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 286 Obie Obie NNP work_arndyvdyobgtlpeh4rho7pywpi 289 287 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 289 288 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 289 Cole Cole NNP work_arndyvdyobgtlpeh4rho7pywpi 289 290 RN RN NNP work_arndyvdyobgtlpeh4rho7pywpi 289 291 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 292 Morton Morton NNP work_arndyvdyobgtlpeh4rho7pywpi 289 293 DH DH NNP work_arndyvdyobgtlpeh4rho7pywpi 289 294 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 295 Packman Packman NNP work_arndyvdyobgtlpeh4rho7pywpi 289 296 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 289 297 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 298 Baumgartner Baumgartner NNP work_arndyvdyobgtlpeh4rho7pywpi 289 299 ER ER NNP work_arndyvdyobgtlpeh4rho7pywpi 289 300 , , , work_arndyvdyobgtlpeh4rho7pywpi 289 301 Valle Valle NNP work_arndyvdyobgtlpeh4rho7pywpi 289 302 D. D. NNP work_arndyvdyobgtlpeh4rho7pywpi 289 303 The the DT work_arndyvdyobgtlpeh4rho7pywpi 289 304 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 289 305 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 289 306 of of IN work_arndyvdyobgtlpeh4rho7pywpi 289 307 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 289 308 3-methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 289 309 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 289 310 car- car- POS work_arndyvdyobgtlpeh4rho7pywpi 289 311 boxylase boxylase NN work_arndyvdyobgtlpeh4rho7pywpi 289 312 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 289 313 . . . work_arndyvdyobgtlpeh4rho7pywpi 290 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 290 2 Clin Clin NNP work_arndyvdyobgtlpeh4rho7pywpi 290 3 Invest Invest NNP work_arndyvdyobgtlpeh4rho7pywpi 290 4 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 290 5 in in IN work_arndyvdyobgtlpeh4rho7pywpi 290 6 press press NN work_arndyvdyobgtlpeh4rho7pywpi 290 7 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 290 8 Beltrán Beltrán NNP work_arndyvdyobgtlpeh4rho7pywpi 290 9 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 290 10 Valero Valero NNP work_arndyvdyobgtlpeh4rho7pywpi 290 11 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 290 12 Bernabé Bernabé NNP work_arndyvdyobgtlpeh4rho7pywpi 290 13 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 290 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 15 Granadino Granadino NNP work_arndyvdyobgtlpeh4rho7pywpi 290 16 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 290 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 18 Chiarelli Chiarelli NNP work_arndyvdyobgtlpeh4rho7pywpi 290 19 I I NNP work_arndyvdyobgtlpeh4rho7pywpi 290 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 21 Porfirio Porfirio NNP work_arndyvdyobgtlpeh4rho7pywpi 290 22 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 290 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 24 Mayatepek Mayatepek NNP work_arndyvdyobgtlpeh4rho7pywpi 290 25 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 290 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 27 Aquaron Aquaron NNP work_arndyvdyobgtlpeh4rho7pywpi 290 28 R R NNP work_arndyvdyobgtlpeh4rho7pywpi 290 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 30 Moore Moore NNP work_arndyvdyobgtlpeh4rho7pywpi 290 31 MM MM NNP work_arndyvdyobgtlpeh4rho7pywpi 290 32 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 33 Festen Festen NNP work_arndyvdyobgtlpeh4rho7pywpi 290 34 JJ JJ NNP work_arndyvdyobgtlpeh4rho7pywpi 290 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 36 San- San- NNP work_arndyvdyobgtlpeh4rho7pywpi 290 37 martı́ martı́ NNP work_arndyvdyobgtlpeh4rho7pywpi 290 38 R R NNP work_arndyvdyobgtlpeh4rho7pywpi 290 39 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 40 Peñalva Peñalva NNP work_arndyvdyobgtlpeh4rho7pywpi 290 41 MA MA NNP work_arndyvdyobgtlpeh4rho7pywpi 290 42 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 43 Rodrı́guez Rodrı́guez NNP work_arndyvdyobgtlpeh4rho7pywpi 290 44 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 290 45 Córdoba Córdoba NNP work_arndyvdyobgtlpeh4rho7pywpi 290 46 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 290 47 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 290 48 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 290 49 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 290 50 Mu- mu- JJ work_arndyvdyobgtlpeh4rho7pywpi 290 51 tation tation NN work_arndyvdyobgtlpeh4rho7pywpi 290 52 and and CC work_arndyvdyobgtlpeh4rho7pywpi 290 53 polymorphism polymorphism NN work_arndyvdyobgtlpeh4rho7pywpi 290 54 analysis analysis NN work_arndyvdyobgtlpeh4rho7pywpi 290 55 of of IN work_arndyvdyobgtlpeh4rho7pywpi 290 56 the the DT work_arndyvdyobgtlpeh4rho7pywpi 290 57 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 290 58 homogen- homogen- NN work_arndyvdyobgtlpeh4rho7pywpi 290 59 tisate tisate NNP work_arndyvdyobgtlpeh4rho7pywpi 290 60 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 290 61 , , , work_arndyvdyobgtlpeh4rho7pywpi 290 62 2- 2- LS work_arndyvdyobgtlpeh4rho7pywpi 290 63 dioxygenase dioxygenase NN work_arndyvdyobgtlpeh4rho7pywpi 290 64 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 290 65 in in IN work_arndyvdyobgtlpeh4rho7pywpi 290 66 alkaptonuria alkaptonuria NN work_arndyvdyobgtlpeh4rho7pywpi 290 67 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 290 68 . . . work_arndyvdyobgtlpeh4rho7pywpi 291 1 Am be VBP work_arndyvdyobgtlpeh4rho7pywpi 291 2 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 291 3 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 291 4 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 291 5 62:776–784 62:776–784 NNP work_arndyvdyobgtlpeh4rho7pywpi 291 6 Chuang Chuang NNP work_arndyvdyobgtlpeh4rho7pywpi 291 7 DT DT NNP work_arndyvdyobgtlpeh4rho7pywpi 291 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 291 9 Shih Shih NNP work_arndyvdyobgtlpeh4rho7pywpi 291 10 VE VE NNP work_arndyvdyobgtlpeh4rho7pywpi 291 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 291 12 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 291 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 291 14 Disorders Disorders NNPS work_arndyvdyobgtlpeh4rho7pywpi 291 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 291 16 branched branch VBN work_arndyvdyobgtlpeh4rho7pywpi 291 17 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 291 18 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 291 19 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 291 20 and and CC work_arndyvdyobgtlpeh4rho7pywpi 291 21 ketoacid ketoacid NNP work_arndyvdyobgtlpeh4rho7pywpi 291 22 metabolism metabolism NN work_arndyvdyobgtlpeh4rho7pywpi 291 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 292 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 292 2 : : : work_arndyvdyobgtlpeh4rho7pywpi 292 3 Scriver Scriver NNP work_arndyvdyobgtlpeh4rho7pywpi 292 4 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 292 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 292 6 Beaudet Beaudet NNP work_arndyvdyobgtlpeh4rho7pywpi 292 7 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 292 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 292 9 Sly Sly NNP work_arndyvdyobgtlpeh4rho7pywpi 292 10 W W NNP work_arndyvdyobgtlpeh4rho7pywpi 292 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 292 12 Valle Valle NNP work_arndyvdyobgtlpeh4rho7pywpi 292 13 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 292 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 292 15 eds eds NNP work_arndyvdyobgtlpeh4rho7pywpi 292 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 292 17 The the DT work_arndyvdyobgtlpeh4rho7pywpi 292 18 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 292 19 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 292 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 292 21 inherited inherit VBN work_arndyvdyobgtlpeh4rho7pywpi 292 22 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 292 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 292 24 7th 7th JJ work_arndyvdyobgtlpeh4rho7pywpi 292 25 ed ed NNP work_arndyvdyobgtlpeh4rho7pywpi 292 26 . . . work_arndyvdyobgtlpeh4rho7pywpi 293 1 McGraw McGraw NNP work_arndyvdyobgtlpeh4rho7pywpi 293 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 293 3 Hill Hill NNP work_arndyvdyobgtlpeh4rho7pywpi 293 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 293 5 New New NNP work_arndyvdyobgtlpeh4rho7pywpi 293 6 York York NNP work_arndyvdyobgtlpeh4rho7pywpi 293 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 293 8 pp pp NNP work_arndyvdyobgtlpeh4rho7pywpi 293 9 1239–1276 1239–1276 CD work_arndyvdyobgtlpeh4rho7pywpi 293 10 Cotton Cotton NNP work_arndyvdyobgtlpeh4rho7pywpi 293 11 RGH RGH NNP work_arndyvdyobgtlpeh4rho7pywpi 293 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 293 13 Horaitis Horaitis NNP work_arndyvdyobgtlpeh4rho7pywpi 293 14 O o NN work_arndyvdyobgtlpeh4rho7pywpi 293 15 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 293 16 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 293 17 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 293 18 Quality quality NN work_arndyvdyobgtlpeh4rho7pywpi 293 19 control control NN work_arndyvdyobgtlpeh4rho7pywpi 293 20 in in IN work_arndyvdyobgtlpeh4rho7pywpi 293 21 the the DT work_arndyvdyobgtlpeh4rho7pywpi 293 22 dis- dis- NN work_arndyvdyobgtlpeh4rho7pywpi 293 23 covery covery NN work_arndyvdyobgtlpeh4rho7pywpi 293 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 293 25 reporting reporting NN work_arndyvdyobgtlpeh4rho7pywpi 293 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 293 27 recording recording NN work_arndyvdyobgtlpeh4rho7pywpi 293 28 of of IN work_arndyvdyobgtlpeh4rho7pywpi 293 29 genomic genomic JJ work_arndyvdyobgtlpeh4rho7pywpi 293 30 variation variation NN work_arndyvdyobgtlpeh4rho7pywpi 293 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 294 1 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 294 2 Mutat Mutat NNP work_arndyvdyobgtlpeh4rho7pywpi 294 3 15:16–21 15:16–21 NNP work_arndyvdyobgtlpeh4rho7pywpi 294 4 Fernández Fernández NNP work_arndyvdyobgtlpeh4rho7pywpi 294 5 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 294 6 Cañón Cañón NNP work_arndyvdyobgtlpeh4rho7pywpi 294 7 JM JM NNP work_arndyvdyobgtlpeh4rho7pywpi 294 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 294 9 Granadino Granadino NNP work_arndyvdyobgtlpeh4rho7pywpi 294 10 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 294 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 294 12 Beltrán Beltrán NNP work_arndyvdyobgtlpeh4rho7pywpi 294 13 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 294 14 Valero Valero NNP work_arndyvdyobgtlpeh4rho7pywpi 294 15 de de NNP work_arndyvdyobgtlpeh4rho7pywpi 294 16 Ber- Ber- NNP work_arndyvdyobgtlpeh4rho7pywpi 294 17 nabé nabé NNP work_arndyvdyobgtlpeh4rho7pywpi 294 18 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 294 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 294 20 Renedo Renedo NNP work_arndyvdyobgtlpeh4rho7pywpi 294 21 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 294 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 294 23 Fernández Fernández NNP work_arndyvdyobgtlpeh4rho7pywpi 294 24 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 294 25 Ruiz Ruiz NNP work_arndyvdyobgtlpeh4rho7pywpi 294 26 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 294 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 294 28 Peñalva Peñalva NNP work_arndyvdyobgtlpeh4rho7pywpi 294 29 MA MA NNP work_arndyvdyobgtlpeh4rho7pywpi 294 30 , , , work_arndyvdyobgtlpeh4rho7pywpi 294 31 Ro- ro- UH work_arndyvdyobgtlpeh4rho7pywpi 294 32 drı́guez drı́guez NN work_arndyvdyobgtlpeh4rho7pywpi 294 33 de de FW work_arndyvdyobgtlpeh4rho7pywpi 294 34 Córdoba Córdoba NNP work_arndyvdyobgtlpeh4rho7pywpi 294 35 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 294 36 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 294 37 1996 1996 CD work_arndyvdyobgtlpeh4rho7pywpi 294 38 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 294 39 The the DT work_arndyvdyobgtlpeh4rho7pywpi 294 40 molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 294 41 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 294 42 of of IN work_arndyvdyobgtlpeh4rho7pywpi 294 43 alkap- alkap- NNP work_arndyvdyobgtlpeh4rho7pywpi 294 44 tonuria tonuria NNP work_arndyvdyobgtlpeh4rho7pywpi 294 45 . . . work_arndyvdyobgtlpeh4rho7pywpi 295 1 Nat Nat NNP work_arndyvdyobgtlpeh4rho7pywpi 295 2 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 295 3 14:19–24 14:19–24 CD work_arndyvdyobgtlpeh4rho7pywpi 295 4 Fernández Fernández NNP work_arndyvdyobgtlpeh4rho7pywpi 295 5 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 295 6 Cañón Cañón NNP work_arndyvdyobgtlpeh4rho7pywpi 295 7 JM JM NNP work_arndyvdyobgtlpeh4rho7pywpi 295 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 295 9 Peñalva Peñalva NNP work_arndyvdyobgtlpeh4rho7pywpi 295 10 MA MA NNP work_arndyvdyobgtlpeh4rho7pywpi 295 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 295 12 1995a 1995a CD work_arndyvdyobgtlpeh4rho7pywpi 295 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 295 14 Fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 295 15 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 295 16 model model NN work_arndyvdyobgtlpeh4rho7pywpi 295 17 for for IN work_arndyvdyobgtlpeh4rho7pywpi 295 18 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 295 19 type type NN work_arndyvdyobgtlpeh4rho7pywpi 295 20 I -PRON- PRP work_arndyvdyobgtlpeh4rho7pywpi 295 21 hereditary hereditary JJ work_arndyvdyobgtlpeh4rho7pywpi 295 22 tyrosinemia tyrosinemia NN work_arndyvdyobgtlpeh4rho7pywpi 295 23 . . . work_arndyvdyobgtlpeh4rho7pywpi 296 1 Proc Proc NNP work_arndyvdyobgtlpeh4rho7pywpi 296 2 Natl Natl NNP work_arndyvdyobgtlpeh4rho7pywpi 296 3 Acad Acad NNP work_arndyvdyobgtlpeh4rho7pywpi 296 4 Sci Sci NNP work_arndyvdyobgtlpeh4rho7pywpi 296 5 USA USA NNP work_arndyvdyobgtlpeh4rho7pywpi 296 6 92:9132–9136 92:9132–9136 CD work_arndyvdyobgtlpeh4rho7pywpi 296 7 — — : work_arndyvdyobgtlpeh4rho7pywpi 296 8 — — : work_arndyvdyobgtlpeh4rho7pywpi 296 9 — — : work_arndyvdyobgtlpeh4rho7pywpi 296 10 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 296 11 1995b 1995b LS work_arndyvdyobgtlpeh4rho7pywpi 296 12 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 296 13 Molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 296 14 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 296 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 296 16 a a DT work_arndyvdyobgtlpeh4rho7pywpi 296 17 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 296 18 encod- encod- XX work_arndyvdyobgtlpeh4rho7pywpi 296 19 ing e VBG work_arndyvdyobgtlpeh4rho7pywpi 296 20 a a DT work_arndyvdyobgtlpeh4rho7pywpi 296 21 homogentisate homogentisate NN work_arndyvdyobgtlpeh4rho7pywpi 296 22 dioxygenase dioxygenase NN work_arndyvdyobgtlpeh4rho7pywpi 296 23 from from IN work_arndyvdyobgtlpeh4rho7pywpi 296 24 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 296 25 nidulans nidulan NNS work_arndyvdyobgtlpeh4rho7pywpi 296 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 296 27 identification identification NN work_arndyvdyobgtlpeh4rho7pywpi 296 28 of of IN work_arndyvdyobgtlpeh4rho7pywpi 296 29 its -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 296 30 human human NN work_arndyvdyobgtlpeh4rho7pywpi 296 31 and and CC work_arndyvdyobgtlpeh4rho7pywpi 296 32 plant plant NN work_arndyvdyobgtlpeh4rho7pywpi 296 33 homologues homologue NNS work_arndyvdyobgtlpeh4rho7pywpi 296 34 . . . work_arndyvdyobgtlpeh4rho7pywpi 297 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 297 2 Biol Biol NNP work_arndyvdyobgtlpeh4rho7pywpi 297 3 Chem Chem NNP work_arndyvdyobgtlpeh4rho7pywpi 297 4 270:21199–21205 270:21199–21205 NNP work_arndyvdyobgtlpeh4rho7pywpi 297 5 — — : work_arndyvdyobgtlpeh4rho7pywpi 297 6 — — : work_arndyvdyobgtlpeh4rho7pywpi 297 7 — — : work_arndyvdyobgtlpeh4rho7pywpi 297 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 297 9 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 297 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 297 11 Characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 297 12 of of IN work_arndyvdyobgtlpeh4rho7pywpi 297 13 a a DT work_arndyvdyobgtlpeh4rho7pywpi 297 14 fungal fungal JJ work_arndyvdyobgtlpeh4rho7pywpi 297 15 maleylacetoace- maleylacetoace- NNP work_arndyvdyobgtlpeh4rho7pywpi 297 16 tate tate NNP work_arndyvdyobgtlpeh4rho7pywpi 297 17 isomerase isomerase NNP work_arndyvdyobgtlpeh4rho7pywpi 297 18 gene gene NN work_arndyvdyobgtlpeh4rho7pywpi 297 19 and and CC work_arndyvdyobgtlpeh4rho7pywpi 297 20 identification identification NN work_arndyvdyobgtlpeh4rho7pywpi 297 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 297 22 its -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 297 23 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 297 24 homo- homo- JJ work_arndyvdyobgtlpeh4rho7pywpi 297 25 logue logue NN work_arndyvdyobgtlpeh4rho7pywpi 297 26 . . . work_arndyvdyobgtlpeh4rho7pywpi 298 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 298 2 Biol Biol NNP work_arndyvdyobgtlpeh4rho7pywpi 298 3 Chem Chem NNP work_arndyvdyobgtlpeh4rho7pywpi 298 4 273:329–337 273:329–337 CD work_arndyvdyobgtlpeh4rho7pywpi 298 5 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 298 6 KM KM NNP work_arndyvdyobgtlpeh4rho7pywpi 298 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 298 8 Bennet Bennet NNP work_arndyvdyobgtlpeh4rho7pywpi 298 9 MJ MJ NNP work_arndyvdyobgtlpeh4rho7pywpi 298 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 298 11 Naylor Naylor NNP work_arndyvdyobgtlpeh4rho7pywpi 298 12 EW EW NNP work_arndyvdyobgtlpeh4rho7pywpi 298 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 298 14 Morton Morton NNP work_arndyvdyobgtlpeh4rho7pywpi 298 15 DH DH NNP work_arndyvdyobgtlpeh4rho7pywpi 298 16 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 298 17 1998 1998 CD work_arndyvdyobgtlpeh4rho7pywpi 298 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 298 19 3- 3- NNP work_arndyvdyobgtlpeh4rho7pywpi 298 20 Methylcrotonyl Methylcrotonyl NNP work_arndyvdyobgtlpeh4rho7pywpi 298 21 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 298 22 coenzyme coenzyme VBZ work_arndyvdyobgtlpeh4rho7pywpi 298 23 A a DT work_arndyvdyobgtlpeh4rho7pywpi 298 24 carboxylase carboxylase JJ work_arndyvdyobgtlpeh4rho7pywpi 298 25 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 298 26 in in IN work_arndyvdyobgtlpeh4rho7pywpi 298 27 Amish Amish NNP work_arndyvdyobgtlpeh4rho7pywpi 298 28 / / SYM work_arndyvdyobgtlpeh4rho7pywpi 298 29 Mennonite Mennonite NNP work_arndyvdyobgtlpeh4rho7pywpi 298 30 adults adult NNS work_arndyvdyobgtlpeh4rho7pywpi 298 31 identified identify VBN work_arndyvdyobgtlpeh4rho7pywpi 298 32 by by IN work_arndyvdyobgtlpeh4rho7pywpi 298 33 detection detection NN work_arndyvdyobgtlpeh4rho7pywpi 298 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 298 35 increased increase VBN work_arndyvdyobgtlpeh4rho7pywpi 298 36 acylcarnitines acylcarnitine NNS work_arndyvdyobgtlpeh4rho7pywpi 298 37 in in IN work_arndyvdyobgtlpeh4rho7pywpi 298 38 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 298 39 spots spot NNS work_arndyvdyobgtlpeh4rho7pywpi 298 40 of of IN work_arndyvdyobgtlpeh4rho7pywpi 298 41 their -PRON- PRP$ work_arndyvdyobgtlpeh4rho7pywpi 298 42 children child NNS work_arndyvdyobgtlpeh4rho7pywpi 298 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 299 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 299 2 Pediatr Pediatr NNP work_arndyvdyobgtlpeh4rho7pywpi 299 3 132 132 CD work_arndyvdyobgtlpeh4rho7pywpi 299 4 : : : work_arndyvdyobgtlpeh4rho7pywpi 299 5 519–523 519–523 CD work_arndyvdyobgtlpeh4rho7pywpi 299 6 Gibson Gibson NNP work_arndyvdyobgtlpeh4rho7pywpi 299 7 KM KM NNP work_arndyvdyobgtlpeh4rho7pywpi 299 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 299 9 Ugarte Ugarte NNP work_arndyvdyobgtlpeh4rho7pywpi 299 10 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 299 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 299 12 Fukao Fukao NNP work_arndyvdyobgtlpeh4rho7pywpi 299 13 T T NNP work_arndyvdyobgtlpeh4rho7pywpi 299 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 299 15 Mitchell Mitchell NNP work_arndyvdyobgtlpeh4rho7pywpi 299 16 GA GA NNP work_arndyvdyobgtlpeh4rho7pywpi 299 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 299 18 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 299 19 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 299 20 Molec- Molec- NNP work_arndyvdyobgtlpeh4rho7pywpi 299 21 ular ular JJ work_arndyvdyobgtlpeh4rho7pywpi 299 22 and and CC work_arndyvdyobgtlpeh4rho7pywpi 299 23 enzymatic enzymatic JJ work_arndyvdyobgtlpeh4rho7pywpi 299 24 methods method NNS work_arndyvdyobgtlpeh4rho7pywpi 299 25 for for IN work_arndyvdyobgtlpeh4rho7pywpi 299 26 detection detection NN work_arndyvdyobgtlpeh4rho7pywpi 299 27 of of IN work_arndyvdyobgtlpeh4rho7pywpi 299 28 genetic genetic JJ work_arndyvdyobgtlpeh4rho7pywpi 299 29 defects defect NNS work_arndyvdyobgtlpeh4rho7pywpi 299 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 299 31 distal distal JJ work_arndyvdyobgtlpeh4rho7pywpi 299 32 pathways pathway NNS work_arndyvdyobgtlpeh4rho7pywpi 299 33 of of IN work_arndyvdyobgtlpeh4rho7pywpi 299 34 branched branched JJ work_arndyvdyobgtlpeh4rho7pywpi 299 35 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 299 36 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 299 37 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 299 38 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 299 39 metabo- metabo- NNP work_arndyvdyobgtlpeh4rho7pywpi 299 40 lism lism NNP work_arndyvdyobgtlpeh4rho7pywpi 299 41 . . . work_arndyvdyobgtlpeh4rho7pywpi 300 1 Methods Methods NNP work_arndyvdyobgtlpeh4rho7pywpi 300 2 Enzymol Enzymol NNP work_arndyvdyobgtlpeh4rho7pywpi 300 3 324:432–453 324:432–453 CD work_arndyvdyobgtlpeh4rho7pywpi 300 4 Goldberg Goldberg NNP work_arndyvdyobgtlpeh4rho7pywpi 300 5 AL AL NNP work_arndyvdyobgtlpeh4rho7pywpi 300 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 300 7 Chang Chang NNP work_arndyvdyobgtlpeh4rho7pywpi 300 8 TW TW NNP work_arndyvdyobgtlpeh4rho7pywpi 300 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 300 10 1978 1978 CD work_arndyvdyobgtlpeh4rho7pywpi 300 11 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 300 12 Regulation regulation NN work_arndyvdyobgtlpeh4rho7pywpi 300 13 and and CC work_arndyvdyobgtlpeh4rho7pywpi 300 14 significance significance NN work_arndyvdyobgtlpeh4rho7pywpi 300 15 of of IN work_arndyvdyobgtlpeh4rho7pywpi 300 16 amino amino JJ work_arndyvdyobgtlpeh4rho7pywpi 300 17 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 300 18 metabolism metabolism NN work_arndyvdyobgtlpeh4rho7pywpi 300 19 in in IN work_arndyvdyobgtlpeh4rho7pywpi 300 20 skeletal skeletal JJ work_arndyvdyobgtlpeh4rho7pywpi 300 21 muscle muscle NN work_arndyvdyobgtlpeh4rho7pywpi 300 22 . . . work_arndyvdyobgtlpeh4rho7pywpi 301 1 Fed Fed NNP work_arndyvdyobgtlpeh4rho7pywpi 301 2 Proc Proc NNP work_arndyvdyobgtlpeh4rho7pywpi 301 3 37 37 CD work_arndyvdyobgtlpeh4rho7pywpi 301 4 : : : work_arndyvdyobgtlpeh4rho7pywpi 301 5 2301–2307 2301–2307 CD work_arndyvdyobgtlpeh4rho7pywpi 301 6 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 301 7 RA RA NNP work_arndyvdyobgtlpeh4rho7pywpi 301 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 301 9 Lam Lam NNP work_arndyvdyobgtlpeh4rho7pywpi 301 10 KF KF NNP work_arndyvdyobgtlpeh4rho7pywpi 301 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 301 12 Scully scully RB work_arndyvdyobgtlpeh4rho7pywpi 301 13 KJ KJ NNP work_arndyvdyobgtlpeh4rho7pywpi 301 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 301 15 Hia Hia NNP work_arndyvdyobgtlpeh4rho7pywpi 301 16 Y Y NNP work_arndyvdyobgtlpeh4rho7pywpi 301 17 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 301 18 1977 1977 CD work_arndyvdyobgtlpeh4rho7pywpi 301 19 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 301 20 Genetic genetic JJ work_arndyvdyobgtlpeh4rho7pywpi 301 21 com- com- NN work_arndyvdyobgtlpeh4rho7pywpi 301 22 plementation plementation NN work_arndyvdyobgtlpeh4rho7pywpi 301 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 301 24 propionyl propionyl NN work_arndyvdyobgtlpeh4rho7pywpi 301 25 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 301 26 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 301 27 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 301 28 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 301 29 in in IN work_arndyvdyobgtlpeh4rho7pywpi 301 30 cultured cultured JJ work_arndyvdyobgtlpeh4rho7pywpi 301 31 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 301 32 fibroblasts fibroblast NNS work_arndyvdyobgtlpeh4rho7pywpi 301 33 . . . work_arndyvdyobgtlpeh4rho7pywpi 302 1 Am be VBP work_arndyvdyobgtlpeh4rho7pywpi 302 2 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 302 3 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 302 4 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 302 5 29:378–388 29:378–388 NNP work_arndyvdyobgtlpeh4rho7pywpi 302 6 Gyapay Gyapay NNP work_arndyvdyobgtlpeh4rho7pywpi 302 7 G g NN work_arndyvdyobgtlpeh4rho7pywpi 302 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 9 Schmitt Schmitt NNP work_arndyvdyobgtlpeh4rho7pywpi 302 10 K K NNP work_arndyvdyobgtlpeh4rho7pywpi 302 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 12 Fizames Fizames NNP work_arndyvdyobgtlpeh4rho7pywpi 302 13 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 302 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 15 Jones Jones NNP work_arndyvdyobgtlpeh4rho7pywpi 302 16 H H NNP work_arndyvdyobgtlpeh4rho7pywpi 302 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 18 Vega Vega NNP work_arndyvdyobgtlpeh4rho7pywpi 302 19 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 302 20 Czarny Czarny NNP work_arndyvdyobgtlpeh4rho7pywpi 302 21 N N NNP work_arndyvdyobgtlpeh4rho7pywpi 302 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 23 Spillett Spillett NNP work_arndyvdyobgtlpeh4rho7pywpi 302 24 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 302 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 26 Muselet Muselet NNP work_arndyvdyobgtlpeh4rho7pywpi 302 27 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 302 28 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 29 Prud’Homme Prud’Homme NNP work_arndyvdyobgtlpeh4rho7pywpi 302 30 JF JF NNP work_arndyvdyobgtlpeh4rho7pywpi 302 31 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 32 Dib Dib NNP work_arndyvdyobgtlpeh4rho7pywpi 302 33 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 302 34 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 35 Auffray Auffray NNP work_arndyvdyobgtlpeh4rho7pywpi 302 36 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 302 37 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 38 Morissette Morissette NNP work_arndyvdyobgtlpeh4rho7pywpi 302 39 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 302 40 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 41 Weissenbach Weissenbach NNP work_arndyvdyobgtlpeh4rho7pywpi 302 42 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 302 43 , , , work_arndyvdyobgtlpeh4rho7pywpi 302 44 Goodfellow Goodfellow NNP work_arndyvdyobgtlpeh4rho7pywpi 302 45 PN PN NNP work_arndyvdyobgtlpeh4rho7pywpi 302 46 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 302 47 1996 1996 CD work_arndyvdyobgtlpeh4rho7pywpi 302 48 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 302 49 A a DT work_arndyvdyobgtlpeh4rho7pywpi 302 50 ra- ra- JJ work_arndyvdyobgtlpeh4rho7pywpi 302 51 diation diation NN work_arndyvdyobgtlpeh4rho7pywpi 302 52 hybrid hybrid JJ work_arndyvdyobgtlpeh4rho7pywpi 302 53 map map NN work_arndyvdyobgtlpeh4rho7pywpi 302 54 of of IN work_arndyvdyobgtlpeh4rho7pywpi 302 55 the the DT work_arndyvdyobgtlpeh4rho7pywpi 302 56 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 302 57 genome genome NN work_arndyvdyobgtlpeh4rho7pywpi 302 58 . . . work_arndyvdyobgtlpeh4rho7pywpi 303 1 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 303 2 Mol Mol NNP work_arndyvdyobgtlpeh4rho7pywpi 303 3 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 303 4 5:339–346 5:339–346 CD work_arndyvdyobgtlpeh4rho7pywpi 303 5 Lamhonwah Lamhonwah NNP work_arndyvdyobgtlpeh4rho7pywpi 303 6 AM am NN work_arndyvdyobgtlpeh4rho7pywpi 303 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 303 8 Barankiewicz Barankiewicz NNP work_arndyvdyobgtlpeh4rho7pywpi 303 9 TJ TJ NNP work_arndyvdyobgtlpeh4rho7pywpi 303 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 303 11 Willard Willard NNP work_arndyvdyobgtlpeh4rho7pywpi 303 12 HF HF NNP work_arndyvdyobgtlpeh4rho7pywpi 303 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 303 14 Mahuran Mahuran NNP work_arndyvdyobgtlpeh4rho7pywpi 303 15 DJ DJ NNP work_arndyvdyobgtlpeh4rho7pywpi 303 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 303 17 Quan Quan NNP work_arndyvdyobgtlpeh4rho7pywpi 303 18 F F NNP work_arndyvdyobgtlpeh4rho7pywpi 303 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 303 20 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 303 21 RA RA NNP work_arndyvdyobgtlpeh4rho7pywpi 303 22 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 303 23 1986 1986 CD work_arndyvdyobgtlpeh4rho7pywpi 303 24 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 303 25 Isolation isolation NN work_arndyvdyobgtlpeh4rho7pywpi 303 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 303 27 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 303 28 clones clone NNS work_arndyvdyobgtlpeh4rho7pywpi 303 29 coding code VBG work_arndyvdyobgtlpeh4rho7pywpi 303 30 for for IN work_arndyvdyobgtlpeh4rho7pywpi 303 31 the the DT work_arndyvdyobgtlpeh4rho7pywpi 303 32 alpha alpha NN work_arndyvdyobgtlpeh4rho7pywpi 303 33 and and CC work_arndyvdyobgtlpeh4rho7pywpi 303 34 beta beta NN work_arndyvdyobgtlpeh4rho7pywpi 303 35 chains chain NNS work_arndyvdyobgtlpeh4rho7pywpi 303 36 of of IN work_arndyvdyobgtlpeh4rho7pywpi 303 37 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 303 38 propionyl propionyl NN work_arndyvdyobgtlpeh4rho7pywpi 303 39 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 303 40 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 303 41 car- car- NNP work_arndyvdyobgtlpeh4rho7pywpi 303 42 boxylase boxylase NN work_arndyvdyobgtlpeh4rho7pywpi 303 43 : : : work_arndyvdyobgtlpeh4rho7pywpi 303 44 chromosomal chromosomal JJ work_arndyvdyobgtlpeh4rho7pywpi 303 45 assignments assignment NNS work_arndyvdyobgtlpeh4rho7pywpi 303 46 and and CC work_arndyvdyobgtlpeh4rho7pywpi 303 47 DNA dna NN work_arndyvdyobgtlpeh4rho7pywpi 303 48 polymor- polymor- NN work_arndyvdyobgtlpeh4rho7pywpi 303 49 phisms phism NNS work_arndyvdyobgtlpeh4rho7pywpi 303 50 associated associate VBN work_arndyvdyobgtlpeh4rho7pywpi 303 51 with with IN work_arndyvdyobgtlpeh4rho7pywpi 303 52 PCCA PCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 303 53 and and CC work_arndyvdyobgtlpeh4rho7pywpi 303 54 PCCB PCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 303 55 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 303 56 . . . work_arndyvdyobgtlpeh4rho7pywpi 304 1 Proc Proc NNP work_arndyvdyobgtlpeh4rho7pywpi 304 2 Natl Natl NNP work_arndyvdyobgtlpeh4rho7pywpi 304 3 Acad Acad NNP work_arndyvdyobgtlpeh4rho7pywpi 304 4 Sci Sci NNP work_arndyvdyobgtlpeh4rho7pywpi 304 5 USA USA NNP work_arndyvdyobgtlpeh4rho7pywpi 304 6 83:4864–4868 83:4864–4868 CD work_arndyvdyobgtlpeh4rho7pywpi 304 7 Lamhonwah Lamhonwah NNP work_arndyvdyobgtlpeh4rho7pywpi 304 8 AM AM NNP work_arndyvdyobgtlpeh4rho7pywpi 304 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 304 10 Lam Lam NNP work_arndyvdyobgtlpeh4rho7pywpi 304 11 KF KF NNP work_arndyvdyobgtlpeh4rho7pywpi 304 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 304 13 Tsui Tsui NNP work_arndyvdyobgtlpeh4rho7pywpi 304 14 F F NNP work_arndyvdyobgtlpeh4rho7pywpi 304 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 304 16 Robinson Robinson NNP work_arndyvdyobgtlpeh4rho7pywpi 304 17 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 304 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 304 19 Saunders Saunders NNP work_arndyvdyobgtlpeh4rho7pywpi 304 20 ME ME NNP work_arndyvdyobgtlpeh4rho7pywpi 304 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 304 22 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 304 23 RA RA NNP work_arndyvdyobgtlpeh4rho7pywpi 304 24 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 304 25 1983 1983 CD work_arndyvdyobgtlpeh4rho7pywpi 304 26 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 304 27 Assignment assignment NN work_arndyvdyobgtlpeh4rho7pywpi 304 28 of of IN work_arndyvdyobgtlpeh4rho7pywpi 304 29 the the DT work_arndyvdyobgtlpeh4rho7pywpi 304 30 a a NN work_arndyvdyobgtlpeh4rho7pywpi 304 31 and and CC work_arndyvdyobgtlpeh4rho7pywpi 304 32 b b NN work_arndyvdyobgtlpeh4rho7pywpi 304 33 chains chain NNS work_arndyvdyobgtlpeh4rho7pywpi 304 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 304 35 hu- hu- JJ work_arndyvdyobgtlpeh4rho7pywpi 304 36 man man NN work_arndyvdyobgtlpeh4rho7pywpi 304 37 propionyl propionyl NNP work_arndyvdyobgtlpeh4rho7pywpi 304 38 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 304 39 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 304 40 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 304 41 to to IN work_arndyvdyobgtlpeh4rho7pywpi 304 42 genetic genetic JJ work_arndyvdyobgtlpeh4rho7pywpi 304 43 complementa- complementa- JJ work_arndyvdyobgtlpeh4rho7pywpi 304 44 tion tion NN work_arndyvdyobgtlpeh4rho7pywpi 304 45 groups group NNS work_arndyvdyobgtlpeh4rho7pywpi 304 46 . . . work_arndyvdyobgtlpeh4rho7pywpi 305 1 Am be VBP work_arndyvdyobgtlpeh4rho7pywpi 305 2 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 305 3 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 305 4 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 305 5 35:889–899 35:889–899 ADD work_arndyvdyobgtlpeh4rho7pywpi 305 6 Lau lau NN work_arndyvdyobgtlpeh4rho7pywpi 305 7 EP EP NNP work_arndyvdyobgtlpeh4rho7pywpi 305 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 305 9 Cochran Cochran NNP work_arndyvdyobgtlpeh4rho7pywpi 305 10 BC BC NNP work_arndyvdyobgtlpeh4rho7pywpi 305 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 305 12 Fall Fall NNP work_arndyvdyobgtlpeh4rho7pywpi 305 13 RR rr NN work_arndyvdyobgtlpeh4rho7pywpi 305 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 305 15 1980 1980 CD work_arndyvdyobgtlpeh4rho7pywpi 305 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 305 17 Isolation isolation NN work_arndyvdyobgtlpeh4rho7pywpi 305 18 of of IN work_arndyvdyobgtlpeh4rho7pywpi 305 19 3-methyl- 3-methyl- NNP work_arndyvdyobgtlpeh4rho7pywpi 305 20 crotonyl crotonyl NN work_arndyvdyobgtlpeh4rho7pywpi 305 21 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 305 22 coenzyme coenzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 305 23 A a DT work_arndyvdyobgtlpeh4rho7pywpi 305 24 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 305 25 from from IN work_arndyvdyobgtlpeh4rho7pywpi 305 26 bovine bovine JJ work_arndyvdyobgtlpeh4rho7pywpi 305 27 kidney kidney NN work_arndyvdyobgtlpeh4rho7pywpi 305 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 306 1 Arch Arch NNP work_arndyvdyobgtlpeh4rho7pywpi 306 2 Biochem Biochem NNP work_arndyvdyobgtlpeh4rho7pywpi 306 3 Biophys Biophys NNP work_arndyvdyobgtlpeh4rho7pywpi 306 4 205:352–359 205:352–359 CD work_arndyvdyobgtlpeh4rho7pywpi 306 5 León León NNP work_arndyvdyobgtlpeh4rho7pywpi 306 6 del del NNP work_arndyvdyobgtlpeh4rho7pywpi 306 7 Rı́o Rı́o NNP work_arndyvdyobgtlpeh4rho7pywpi 306 8 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 306 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 306 10 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 306 11 RA RA NNP work_arndyvdyobgtlpeh4rho7pywpi 306 12 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 306 13 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 306 14 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 306 15 Sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 306 16 requirements requirement NNS work_arndyvdyobgtlpeh4rho7pywpi 306 17 for for IN work_arndyvdyobgtlpeh4rho7pywpi 306 18 the the DT work_arndyvdyobgtlpeh4rho7pywpi 306 19 biotinylation biotinylation NN work_arndyvdyobgtlpeh4rho7pywpi 306 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 306 21 carboxyl carboxyl NN work_arndyvdyobgtlpeh4rho7pywpi 306 22 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 306 23 terminal terminal JJ work_arndyvdyobgtlpeh4rho7pywpi 306 24 fragments fragment NNS work_arndyvdyobgtlpeh4rho7pywpi 306 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 306 26 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 306 27 propionyl propionyl NN work_arndyvdyobgtlpeh4rho7pywpi 306 28 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 306 29 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 306 30 carboxylase carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 306 31 alpha alpha NN work_arndyvdyobgtlpeh4rho7pywpi 306 32 subunit subunit NNP work_arndyvdyobgtlpeh4rho7pywpi 306 33 expressed express VBD work_arndyvdyobgtlpeh4rho7pywpi 306 34 in in IN work_arndyvdyobgtlpeh4rho7pywpi 306 35 Es- Es- NNP work_arndyvdyobgtlpeh4rho7pywpi 306 36 cherichia cherichia NNP work_arndyvdyobgtlpeh4rho7pywpi 306 37 coli coli NNS work_arndyvdyobgtlpeh4rho7pywpi 306 38 . . . work_arndyvdyobgtlpeh4rho7pywpi 307 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 307 2 Biol Biol NNP work_arndyvdyobgtlpeh4rho7pywpi 307 3 Chem Chem NNP work_arndyvdyobgtlpeh4rho7pywpi 307 4 269:22964–22968 269:22964–22968 NNP work_arndyvdyobgtlpeh4rho7pywpi 307 5 McKean McKean NNP work_arndyvdyobgtlpeh4rho7pywpi 307 6 AL AL NNP work_arndyvdyobgtlpeh4rho7pywpi 307 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 307 8 Ke Ke NNP work_arndyvdyobgtlpeh4rho7pywpi 307 9 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 307 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 307 11 Song Song NNP work_arndyvdyobgtlpeh4rho7pywpi 307 12 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 307 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 307 14 Che Che NNP work_arndyvdyobgtlpeh4rho7pywpi 307 15 P P NNP work_arndyvdyobgtlpeh4rho7pywpi 307 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 307 17 Achenbach Achenbach NNP work_arndyvdyobgtlpeh4rho7pywpi 307 18 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 307 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 307 20 Nikolau Nikolau NNP work_arndyvdyobgtlpeh4rho7pywpi 307 21 BJ BJ NNP work_arndyvdyobgtlpeh4rho7pywpi 307 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 307 23 Wurtele Wurtele NNP work_arndyvdyobgtlpeh4rho7pywpi 307 24 ES ES NNP work_arndyvdyobgtlpeh4rho7pywpi 307 25 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 307 26 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 307 27 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 307 28 Molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 307 29 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 307 30 of of IN work_arndyvdyobgtlpeh4rho7pywpi 307 31 the the DT work_arndyvdyobgtlpeh4rho7pywpi 307 32 non- non- NNP work_arndyvdyobgtlpeh4rho7pywpi 307 33 biotin biotin NNP work_arndyvdyobgtlpeh4rho7pywpi 307 34 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 307 35 containing contain VBG work_arndyvdyobgtlpeh4rho7pywpi 307 36 subunit subunit NN work_arndyvdyobgtlpeh4rho7pywpi 307 37 of of IN work_arndyvdyobgtlpeh4rho7pywpi 307 38 3-methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 307 39 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 307 40 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 307 41 carbox- carbox- NNP work_arndyvdyobgtlpeh4rho7pywpi 307 42 ylase ylase NNP work_arndyvdyobgtlpeh4rho7pywpi 307 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 308 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 308 2 Biol Biol NNP work_arndyvdyobgtlpeh4rho7pywpi 308 3 Chem Chem NNP work_arndyvdyobgtlpeh4rho7pywpi 308 4 275:5582–5590 275:5582–5590 CD work_arndyvdyobgtlpeh4rho7pywpi 308 5 346 346 CD work_arndyvdyobgtlpeh4rho7pywpi 308 6 Am am NN work_arndyvdyobgtlpeh4rho7pywpi 308 7 . . . work_arndyvdyobgtlpeh4rho7pywpi 309 1 J. J. NNP work_arndyvdyobgtlpeh4rho7pywpi 309 2 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 309 3 . . . work_arndyvdyobgtlpeh4rho7pywpi 310 1 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 310 2 . . . work_arndyvdyobgtlpeh4rho7pywpi 311 1 68:334–346 68:334–346 CD work_arndyvdyobgtlpeh4rho7pywpi 311 2 , , , work_arndyvdyobgtlpeh4rho7pywpi 311 3 2001 2001 CD work_arndyvdyobgtlpeh4rho7pywpi 311 4 Moorhead Moorhead NNP work_arndyvdyobgtlpeh4rho7pywpi 311 5 PS PS NNP work_arndyvdyobgtlpeh4rho7pywpi 311 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 311 7 Nowell Nowell NNP work_arndyvdyobgtlpeh4rho7pywpi 311 8 PC PC NNP work_arndyvdyobgtlpeh4rho7pywpi 311 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 311 10 Mellman Mellman NNP work_arndyvdyobgtlpeh4rho7pywpi 311 11 WJ WJ NNP work_arndyvdyobgtlpeh4rho7pywpi 311 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 311 13 Battips Battips NNP work_arndyvdyobgtlpeh4rho7pywpi 311 14 DM DM NNP work_arndyvdyobgtlpeh4rho7pywpi 311 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 311 16 Hun- Hun- NNP work_arndyvdyobgtlpeh4rho7pywpi 311 17 gerford gerford NN work_arndyvdyobgtlpeh4rho7pywpi 311 18 DA DA NNP work_arndyvdyobgtlpeh4rho7pywpi 311 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 311 20 1960 1960 CD work_arndyvdyobgtlpeh4rho7pywpi 311 21 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 311 22 Chromosome chromosome NN work_arndyvdyobgtlpeh4rho7pywpi 311 23 preparation preparation NN work_arndyvdyobgtlpeh4rho7pywpi 311 24 of of IN work_arndyvdyobgtlpeh4rho7pywpi 311 25 leukocytes leukocyte NNS work_arndyvdyobgtlpeh4rho7pywpi 311 26 cultured cultured JJ work_arndyvdyobgtlpeh4rho7pywpi 311 27 from from IN work_arndyvdyobgtlpeh4rho7pywpi 311 28 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 311 29 peripheral peripheral JJ work_arndyvdyobgtlpeh4rho7pywpi 311 30 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 311 31 . . . work_arndyvdyobgtlpeh4rho7pywpi 312 1 Exp Exp NNP work_arndyvdyobgtlpeh4rho7pywpi 312 2 Cell Cell NNP work_arndyvdyobgtlpeh4rho7pywpi 312 3 Res Res NNP work_arndyvdyobgtlpeh4rho7pywpi 312 4 20 20 CD work_arndyvdyobgtlpeh4rho7pywpi 312 5 : : : work_arndyvdyobgtlpeh4rho7pywpi 312 6 613–616 613–616 CD work_arndyvdyobgtlpeh4rho7pywpi 312 7 Naylor Naylor NNP work_arndyvdyobgtlpeh4rho7pywpi 312 8 EW EW NNP work_arndyvdyobgtlpeh4rho7pywpi 312 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 312 10 Chace Chace NNP work_arndyvdyobgtlpeh4rho7pywpi 312 11 DH DH NNP work_arndyvdyobgtlpeh4rho7pywpi 312 12 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 312 13 1999 1999 CD work_arndyvdyobgtlpeh4rho7pywpi 312 14 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 312 15 Automated automate VBN work_arndyvdyobgtlpeh4rho7pywpi 312 16 tandem tandem NN work_arndyvdyobgtlpeh4rho7pywpi 312 17 mass mass JJ work_arndyvdyobgtlpeh4rho7pywpi 312 18 spec- spec- NN work_arndyvdyobgtlpeh4rho7pywpi 312 19 trometry trometry NN work_arndyvdyobgtlpeh4rho7pywpi 312 20 for for IN work_arndyvdyobgtlpeh4rho7pywpi 312 21 mass mass JJ work_arndyvdyobgtlpeh4rho7pywpi 312 22 newborn newborn JJ work_arndyvdyobgtlpeh4rho7pywpi 312 23 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 312 24 for for IN work_arndyvdyobgtlpeh4rho7pywpi 312 25 disorders disorder NNS work_arndyvdyobgtlpeh4rho7pywpi 312 26 in in IN work_arndyvdyobgtlpeh4rho7pywpi 312 27 fatty fatty NN work_arndyvdyobgtlpeh4rho7pywpi 312 28 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 312 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 312 30 organic organic JJ work_arndyvdyobgtlpeh4rho7pywpi 312 31 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 312 32 , , , work_arndyvdyobgtlpeh4rho7pywpi 312 33 and and CC work_arndyvdyobgtlpeh4rho7pywpi 312 34 amino amino NN work_arndyvdyobgtlpeh4rho7pywpi 312 35 acid acid NN work_arndyvdyobgtlpeh4rho7pywpi 312 36 metabolism metabolism NN work_arndyvdyobgtlpeh4rho7pywpi 312 37 . . . work_arndyvdyobgtlpeh4rho7pywpi 313 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 313 2 Child Child NNP work_arndyvdyobgtlpeh4rho7pywpi 313 3 Neu- Neu- NNP work_arndyvdyobgtlpeh4rho7pywpi 313 4 rol rol VB work_arndyvdyobgtlpeh4rho7pywpi 313 5 14 14 CD work_arndyvdyobgtlpeh4rho7pywpi 313 6 Suppl Suppl NNP work_arndyvdyobgtlpeh4rho7pywpi 313 7 1 1 CD work_arndyvdyobgtlpeh4rho7pywpi 313 8 : : : work_arndyvdyobgtlpeh4rho7pywpi 313 9 S4–S8 S4–S8 NNP work_arndyvdyobgtlpeh4rho7pywpi 313 10 Ranieri Ranieri NNP work_arndyvdyobgtlpeh4rho7pywpi 313 11 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 313 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 313 13 Gerace Gerace NNP work_arndyvdyobgtlpeh4rho7pywpi 313 14 R R NNP work_arndyvdyobgtlpeh4rho7pywpi 313 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 313 16 Barlett Barlett NNP work_arndyvdyobgtlpeh4rho7pywpi 313 17 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 313 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 313 19 Barnard Barnard NNP work_arndyvdyobgtlpeh4rho7pywpi 313 20 K K NNP work_arndyvdyobgtlpeh4rho7pywpi 313 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 313 22 Fletcher Fletcher NNP work_arndyvdyobgtlpeh4rho7pywpi 313 23 JM JM NNP work_arndyvdyobgtlpeh4rho7pywpi 313 24 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 313 25 2000a 2000a LS work_arndyvdyobgtlpeh4rho7pywpi 313 26 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 313 27 The the DT work_arndyvdyobgtlpeh4rho7pywpi 313 28 introduction introduction NN work_arndyvdyobgtlpeh4rho7pywpi 313 29 of of IN work_arndyvdyobgtlpeh4rho7pywpi 313 30 tandem tandem NNP work_arndyvdyobgtlpeh4rho7pywpi 313 31 mass mass NNP work_arndyvdyobgtlpeh4rho7pywpi 313 32 spectrometry spectrometry NNP work_arndyvdyobgtlpeh4rho7pywpi 313 33 into into IN work_arndyvdyobgtlpeh4rho7pywpi 313 34 the the DT work_arndyvdyobgtlpeh4rho7pywpi 313 35 South south JJ work_arndyvdyobgtlpeh4rho7pywpi 313 36 Australian australian JJ work_arndyvdyobgtlpeh4rho7pywpi 313 37 neonatal neonatal JJ work_arndyvdyobgtlpeh4rho7pywpi 313 38 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 313 39 program program NN work_arndyvdyobgtlpeh4rho7pywpi 313 40 : : : work_arndyvdyobgtlpeh4rho7pywpi 313 41 benefits benefit NNS work_arndyvdyobgtlpeh4rho7pywpi 313 42 and and CC work_arndyvdyobgtlpeh4rho7pywpi 313 43 costs cost NNS work_arndyvdyobgtlpeh4rho7pywpi 313 44 . . . work_arndyvdyobgtlpeh4rho7pywpi 314 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 314 2 Inherit Inherit NNP work_arndyvdyobgtlpeh4rho7pywpi 314 3 Metab Metab NNP work_arndyvdyobgtlpeh4rho7pywpi 314 4 Dis Dis NNP work_arndyvdyobgtlpeh4rho7pywpi 314 5 23 23 CD work_arndyvdyobgtlpeh4rho7pywpi 314 6 Suppl Suppl NNP work_arndyvdyobgtlpeh4rho7pywpi 314 7 1:006 1:006 CD work_arndyvdyobgtlpeh4rho7pywpi 314 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 314 9 poster poster NN work_arndyvdyobgtlpeh4rho7pywpi 314 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 314 11 Ranieri Ranieri NNP work_arndyvdyobgtlpeh4rho7pywpi 314 12 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 314 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 314 14 Gerace Gerace NNP work_arndyvdyobgtlpeh4rho7pywpi 314 15 R R NNP work_arndyvdyobgtlpeh4rho7pywpi 314 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 314 17 Metz Metz NNP work_arndyvdyobgtlpeh4rho7pywpi 314 18 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 314 19 , , , work_arndyvdyobgtlpeh4rho7pywpi 314 20 Harrison Harrison NNP work_arndyvdyobgtlpeh4rho7pywpi 314 21 JR JR NNP work_arndyvdyobgtlpeh4rho7pywpi 314 22 , , , work_arndyvdyobgtlpeh4rho7pywpi 314 23 Nelson Nelson NNP work_arndyvdyobgtlpeh4rho7pywpi 314 24 PV PV NNP work_arndyvdyobgtlpeh4rho7pywpi 314 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 314 26 Fietz Fietz NNP work_arndyvdyobgtlpeh4rho7pywpi 314 27 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 314 28 , , , work_arndyvdyobgtlpeh4rho7pywpi 314 29 Fletcher Fletcher NNP work_arndyvdyobgtlpeh4rho7pywpi 314 30 JM JM NNP work_arndyvdyobgtlpeh4rho7pywpi 314 31 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 314 32 2000b 2000b CD work_arndyvdyobgtlpeh4rho7pywpi 314 33 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 314 34 Localisation localisation NN work_arndyvdyobgtlpeh4rho7pywpi 314 35 of of IN work_arndyvdyobgtlpeh4rho7pywpi 314 36 the the DT work_arndyvdyobgtlpeh4rho7pywpi 314 37 3-hydroxyval- 3-hydroxyval- NNS work_arndyvdyobgtlpeh4rho7pywpi 314 38 erylcarnitine erylcarnitine RB work_arndyvdyobgtlpeh4rho7pywpi 314 39 within within IN work_arndyvdyobgtlpeh4rho7pywpi 314 40 the the DT work_arndyvdyobgtlpeh4rho7pywpi 314 41 cellular cellular JJ work_arndyvdyobgtlpeh4rho7pywpi 314 42 fraction fraction NN work_arndyvdyobgtlpeh4rho7pywpi 314 43 of of IN work_arndyvdyobgtlpeh4rho7pywpi 314 44 blood blood NN work_arndyvdyobgtlpeh4rho7pywpi 314 45 in in IN work_arndyvdyobgtlpeh4rho7pywpi 314 46 a a DT work_arndyvdyobgtlpeh4rho7pywpi 314 47 case case NN work_arndyvdyobgtlpeh4rho7pywpi 314 48 of of IN work_arndyvdyobgtlpeh4rho7pywpi 314 49 3-methylcrotonyl 3-methylcrotonyl CD work_arndyvdyobgtlpeh4rho7pywpi 314 50 coenzyme coenzyme NNS work_arndyvdyobgtlpeh4rho7pywpi 314 51 A a DT work_arndyvdyobgtlpeh4rho7pywpi 314 52 carboxylase carboxylase JJ work_arndyvdyobgtlpeh4rho7pywpi 314 53 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 314 54 . . . work_arndyvdyobgtlpeh4rho7pywpi 315 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 315 2 Inherit Inherit NNP work_arndyvdyobgtlpeh4rho7pywpi 315 3 Metab Metab NNP work_arndyvdyobgtlpeh4rho7pywpi 315 4 Dis Dis NNP work_arndyvdyobgtlpeh4rho7pywpi 315 5 23 23 CD work_arndyvdyobgtlpeh4rho7pywpi 315 6 Suppl Suppl NNP work_arndyvdyobgtlpeh4rho7pywpi 315 7 1:177 1:177 CD work_arndyvdyobgtlpeh4rho7pywpi 315 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 315 9 oral oral JJ work_arndyvdyobgtlpeh4rho7pywpi 315 10 presentation presentation NN work_arndyvdyobgtlpeh4rho7pywpi 315 11 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 315 12 Roscher Roscher NNP work_arndyvdyobgtlpeh4rho7pywpi 315 13 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 315 14 , , , work_arndyvdyobgtlpeh4rho7pywpi 315 15 Liebl Liebl NNP work_arndyvdyobgtlpeh4rho7pywpi 315 16 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 315 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 315 18 Fingerhut Fingerhut NNP work_arndyvdyobgtlpeh4rho7pywpi 315 19 R R NNP work_arndyvdyobgtlpeh4rho7pywpi 315 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 315 21 Olgemöller Olgemöller NFP work_arndyvdyobgtlpeh4rho7pywpi 315 22 B b NN work_arndyvdyobgtlpeh4rho7pywpi 315 23 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 315 24 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 315 25 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 315 26 Pro- pro- NN work_arndyvdyobgtlpeh4rho7pywpi 315 27 spective spective JJ work_arndyvdyobgtlpeh4rho7pywpi 315 28 study study NN work_arndyvdyobgtlpeh4rho7pywpi 315 29 of of IN work_arndyvdyobgtlpeh4rho7pywpi 315 30 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 315 31 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 315 32 MS MS NNP work_arndyvdyobgtlpeh4rho7pywpi 315 33 newborn newborn JJ work_arndyvdyobgtlpeh4rho7pywpi 315 34 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 315 35 in in IN work_arndyvdyobgtlpeh4rho7pywpi 315 36 Bavaria Bavaria NNP work_arndyvdyobgtlpeh4rho7pywpi 315 37 , , , work_arndyvdyobgtlpeh4rho7pywpi 315 38 Ger- Ger- NNP work_arndyvdyobgtlpeh4rho7pywpi 315 39 many many JJ work_arndyvdyobgtlpeh4rho7pywpi 315 40 : : : work_arndyvdyobgtlpeh4rho7pywpi 315 41 interim interim JJ work_arndyvdyobgtlpeh4rho7pywpi 315 42 results result NNS work_arndyvdyobgtlpeh4rho7pywpi 315 43 . . . work_arndyvdyobgtlpeh4rho7pywpi 316 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 316 2 Inherit Inherit NNP work_arndyvdyobgtlpeh4rho7pywpi 316 3 Metab Metab NNP work_arndyvdyobgtlpeh4rho7pywpi 316 4 Dis Dis NNP work_arndyvdyobgtlpeh4rho7pywpi 316 5 23 23 CD work_arndyvdyobgtlpeh4rho7pywpi 316 6 Suppl Suppl NNP work_arndyvdyobgtlpeh4rho7pywpi 316 7 1:008 1:008 CD work_arndyvdyobgtlpeh4rho7pywpi 316 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 316 9 poster poster NN work_arndyvdyobgtlpeh4rho7pywpi 316 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 316 11 Scriver Scriver NNP work_arndyvdyobgtlpeh4rho7pywpi 316 12 CR CR NNP work_arndyvdyobgtlpeh4rho7pywpi 316 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 316 14 Waters Waters NNP work_arndyvdyobgtlpeh4rho7pywpi 316 15 PJ PJ NNP work_arndyvdyobgtlpeh4rho7pywpi 316 16 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 316 17 1999 1999 CD work_arndyvdyobgtlpeh4rho7pywpi 316 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 316 19 Monogenic monogenic JJ work_arndyvdyobgtlpeh4rho7pywpi 316 20 traits trait NNS work_arndyvdyobgtlpeh4rho7pywpi 316 21 are be VBP work_arndyvdyobgtlpeh4rho7pywpi 316 22 not not RB work_arndyvdyobgtlpeh4rho7pywpi 316 23 simple simple JJ work_arndyvdyobgtlpeh4rho7pywpi 316 24 : : : work_arndyvdyobgtlpeh4rho7pywpi 316 25 lessons lesson NNS work_arndyvdyobgtlpeh4rho7pywpi 316 26 from from IN work_arndyvdyobgtlpeh4rho7pywpi 316 27 phenylketonuria phenylketonuria NNP work_arndyvdyobgtlpeh4rho7pywpi 316 28 . . . work_arndyvdyobgtlpeh4rho7pywpi 317 1 Trends Trends NNPS work_arndyvdyobgtlpeh4rho7pywpi 317 2 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 317 3 15:267–272 15:267–272 CD work_arndyvdyobgtlpeh4rho7pywpi 317 4 Smith Smith NNP work_arndyvdyobgtlpeh4rho7pywpi 317 5 WE WE NNP work_arndyvdyobgtlpeh4rho7pywpi 317 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 317 7 Muenzer Muenzer NNP work_arndyvdyobgtlpeh4rho7pywpi 317 8 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 317 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 317 10 Frazier Frazier NNP work_arndyvdyobgtlpeh4rho7pywpi 317 11 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 317 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 317 13 Millington Millington NNP work_arndyvdyobgtlpeh4rho7pywpi 317 14 DS DS NNP work_arndyvdyobgtlpeh4rho7pywpi 317 15 Kishnani Kishnani NNP work_arndyvdyobgtlpeh4rho7pywpi 317 16 PS PS NNP work_arndyvdyobgtlpeh4rho7pywpi 317 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 317 18 McDonald McDonald NNP work_arndyvdyobgtlpeh4rho7pywpi 317 19 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 317 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 317 21 Koeberl Koeberl NNP work_arndyvdyobgtlpeh4rho7pywpi 317 22 DD DD NNP work_arndyvdyobgtlpeh4rho7pywpi 317 23 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 317 24 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 317 25 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 317 26 Evaluation Evaluation NNP work_arndyvdyobgtlpeh4rho7pywpi 317 27 of of IN work_arndyvdyobgtlpeh4rho7pywpi 317 28 elevated elevated JJ work_arndyvdyobgtlpeh4rho7pywpi 317 29 hydroxyisovalerylcarnitine hydroxyisovalerylcarnitine NN work_arndyvdyobgtlpeh4rho7pywpi 317 30 in in IN work_arndyvdyobgtlpeh4rho7pywpi 317 31 the the DT work_arndyvdyobgtlpeh4rho7pywpi 317 32 newborn newborn JJ work_arndyvdyobgtlpeh4rho7pywpi 317 33 screen screen NN work_arndyvdyobgtlpeh4rho7pywpi 317 34 by by IN work_arndyvdyobgtlpeh4rho7pywpi 317 35 tandem tandem NNP work_arndyvdyobgtlpeh4rho7pywpi 317 36 mass mass NNP work_arndyvdyobgtlpeh4rho7pywpi 317 37 spectrometry spectrometry NNP work_arndyvdyobgtlpeh4rho7pywpi 317 38 . . . work_arndyvdyobgtlpeh4rho7pywpi 318 1 Am be VBP work_arndyvdyobgtlpeh4rho7pywpi 318 2 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 318 3 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 318 4 Genet Genet NNP work_arndyvdyobgtlpeh4rho7pywpi 318 5 67 67 CD work_arndyvdyobgtlpeh4rho7pywpi 318 6 Suppl Suppl NNP work_arndyvdyobgtlpeh4rho7pywpi 318 7 2:292 2:292 CD work_arndyvdyobgtlpeh4rho7pywpi 318 8 Song Song NNP work_arndyvdyobgtlpeh4rho7pywpi 318 9 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 318 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 318 11 Wurtele Wurtele NNP work_arndyvdyobgtlpeh4rho7pywpi 318 12 ES ES NNP work_arndyvdyobgtlpeh4rho7pywpi 318 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 318 14 Nikolau Nikolau NNP work_arndyvdyobgtlpeh4rho7pywpi 318 15 BJ BJ NNP work_arndyvdyobgtlpeh4rho7pywpi 318 16 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 318 17 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 318 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 318 19 Molecular molecular JJ work_arndyvdyobgtlpeh4rho7pywpi 318 20 cloning cloning NN work_arndyvdyobgtlpeh4rho7pywpi 318 21 and and CC work_arndyvdyobgtlpeh4rho7pywpi 318 22 characterization characterization NN work_arndyvdyobgtlpeh4rho7pywpi 318 23 of of IN work_arndyvdyobgtlpeh4rho7pywpi 318 24 the the DT work_arndyvdyobgtlpeh4rho7pywpi 318 25 cDNA cdna NN work_arndyvdyobgtlpeh4rho7pywpi 318 26 coding code VBG work_arndyvdyobgtlpeh4rho7pywpi 318 27 for for IN work_arndyvdyobgtlpeh4rho7pywpi 318 28 the the DT work_arndyvdyobgtlpeh4rho7pywpi 318 29 biotin biotin NNP work_arndyvdyobgtlpeh4rho7pywpi 318 30 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 318 31 con- con- NN work_arndyvdyobgtlpeh4rho7pywpi 318 32 taining taining NN work_arndyvdyobgtlpeh4rho7pywpi 318 33 subunit subunit NN work_arndyvdyobgtlpeh4rho7pywpi 318 34 of of IN work_arndyvdyobgtlpeh4rho7pywpi 318 35 3-methylcrotonoyl 3-methylcrotonoyl CD work_arndyvdyobgtlpeh4rho7pywpi 318 36 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 318 37 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 318 38 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 318 39 : : : work_arndyvdyobgtlpeh4rho7pywpi 318 40 identification identification NN work_arndyvdyobgtlpeh4rho7pywpi 318 41 of of IN work_arndyvdyobgtlpeh4rho7pywpi 318 42 the the DT work_arndyvdyobgtlpeh4rho7pywpi 318 43 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 318 44 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 318 45 and and CC work_arndyvdyobgtlpeh4rho7pywpi 318 46 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 318 47 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 318 48 carrier carrier NN work_arndyvdyobgtlpeh4rho7pywpi 318 49 domains domain NNS work_arndyvdyobgtlpeh4rho7pywpi 318 50 . . . work_arndyvdyobgtlpeh4rho7pywpi 319 1 Proc Proc NNP work_arndyvdyobgtlpeh4rho7pywpi 319 2 Natl Natl NNP work_arndyvdyobgtlpeh4rho7pywpi 319 3 Acad Acad NNP work_arndyvdyobgtlpeh4rho7pywpi 319 4 Sci Sci NNP work_arndyvdyobgtlpeh4rho7pywpi 319 5 USA USA NNP work_arndyvdyobgtlpeh4rho7pywpi 319 6 91:5779–5783 91:5779–5783 NNP work_arndyvdyobgtlpeh4rho7pywpi 319 7 Stewart Stewart NNP work_arndyvdyobgtlpeh4rho7pywpi 319 8 EA EA NNP work_arndyvdyobgtlpeh4rho7pywpi 319 9 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 10 McKusick McKusick NNP work_arndyvdyobgtlpeh4rho7pywpi 319 11 KB KB NNP work_arndyvdyobgtlpeh4rho7pywpi 319 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 13 Aggarwal Aggarwal NNP work_arndyvdyobgtlpeh4rho7pywpi 319 14 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 319 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 16 Bajorek Bajorek NNP work_arndyvdyobgtlpeh4rho7pywpi 319 17 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 319 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 19 Brady Brady NNP work_arndyvdyobgtlpeh4rho7pywpi 319 20 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 319 21 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 22 Chu Chu NNP work_arndyvdyobgtlpeh4rho7pywpi 319 23 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 319 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 25 Fang Fang NNP work_arndyvdyobgtlpeh4rho7pywpi 319 26 N N NNP work_arndyvdyobgtlpeh4rho7pywpi 319 27 , , , work_arndyvdyobgtlpeh4rho7pywpi 319 28 et et NNP work_arndyvdyobgtlpeh4rho7pywpi 319 29 al al NNP work_arndyvdyobgtlpeh4rho7pywpi 319 30 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 319 31 1997 1997 CD work_arndyvdyobgtlpeh4rho7pywpi 319 32 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 319 33 An an DT work_arndyvdyobgtlpeh4rho7pywpi 319 34 STS STS NNP work_arndyvdyobgtlpeh4rho7pywpi 319 35 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 319 36 based base VBN work_arndyvdyobgtlpeh4rho7pywpi 319 37 radiation radiation NN work_arndyvdyobgtlpeh4rho7pywpi 319 38 hybrid hybrid JJ work_arndyvdyobgtlpeh4rho7pywpi 319 39 map map NN work_arndyvdyobgtlpeh4rho7pywpi 319 40 of of IN work_arndyvdyobgtlpeh4rho7pywpi 319 41 the the DT work_arndyvdyobgtlpeh4rho7pywpi 319 42 human human JJ work_arndyvdyobgtlpeh4rho7pywpi 319 43 genome genome NN work_arndyvdyobgtlpeh4rho7pywpi 319 44 . . . work_arndyvdyobgtlpeh4rho7pywpi 320 1 Genome Genome NNP work_arndyvdyobgtlpeh4rho7pywpi 320 2 Res Res NNP work_arndyvdyobgtlpeh4rho7pywpi 320 3 7:422–433 7:422–433 NNP work_arndyvdyobgtlpeh4rho7pywpi 320 4 Sweetman Sweetman NNP work_arndyvdyobgtlpeh4rho7pywpi 320 5 L L NNP work_arndyvdyobgtlpeh4rho7pywpi 320 6 , , , work_arndyvdyobgtlpeh4rho7pywpi 320 7 Williams Williams NNP work_arndyvdyobgtlpeh4rho7pywpi 320 8 JC JC NNP work_arndyvdyobgtlpeh4rho7pywpi 320 9 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 320 10 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 320 11 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 320 12 Branched branch VBN work_arndyvdyobgtlpeh4rho7pywpi 320 13 chain chain NN work_arndyvdyobgtlpeh4rho7pywpi 320 14 organic organic NNP work_arndyvdyobgtlpeh4rho7pywpi 320 15 ac- ac- IN work_arndyvdyobgtlpeh4rho7pywpi 320 16 idurias idurias NNP work_arndyvdyobgtlpeh4rho7pywpi 320 17 . . . work_arndyvdyobgtlpeh4rho7pywpi 321 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 321 2 : : : work_arndyvdyobgtlpeh4rho7pywpi 321 3 Scriver Scriver NNP work_arndyvdyobgtlpeh4rho7pywpi 321 4 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 321 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 321 6 Beaudet Beaudet NNP work_arndyvdyobgtlpeh4rho7pywpi 321 7 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 321 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 321 9 Sly Sly NNP work_arndyvdyobgtlpeh4rho7pywpi 321 10 W W NNP work_arndyvdyobgtlpeh4rho7pywpi 321 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 321 12 Valle Valle NNP work_arndyvdyobgtlpeh4rho7pywpi 321 13 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 321 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 321 15 eds eds NNP work_arndyvdyobgtlpeh4rho7pywpi 321 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 321 17 The the DT work_arndyvdyobgtlpeh4rho7pywpi 321 18 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 321 19 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 321 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 321 21 inherited inherit VBN work_arndyvdyobgtlpeh4rho7pywpi 321 22 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 321 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 321 24 7th 7th JJ work_arndyvdyobgtlpeh4rho7pywpi 321 25 ed ed NNP work_arndyvdyobgtlpeh4rho7pywpi 321 26 . . . work_arndyvdyobgtlpeh4rho7pywpi 322 1 McGraw McGraw NNP work_arndyvdyobgtlpeh4rho7pywpi 322 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 322 3 Hill Hill NNP work_arndyvdyobgtlpeh4rho7pywpi 322 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 322 5 New New NNP work_arndyvdyobgtlpeh4rho7pywpi 322 6 York York NNP work_arndyvdyobgtlpeh4rho7pywpi 322 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 322 8 pp pp NNP work_arndyvdyobgtlpeh4rho7pywpi 322 9 1387–1422 1387–1422 CD work_arndyvdyobgtlpeh4rho7pywpi 322 10 Thoden thoden NN work_arndyvdyobgtlpeh4rho7pywpi 322 11 JB JB NNP work_arndyvdyobgtlpeh4rho7pywpi 322 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 322 13 Blanchard Blanchard NNP work_arndyvdyobgtlpeh4rho7pywpi 322 14 CZ CZ NNP work_arndyvdyobgtlpeh4rho7pywpi 322 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 322 16 Holden Holden NNP work_arndyvdyobgtlpeh4rho7pywpi 322 17 HM HM NNP work_arndyvdyobgtlpeh4rho7pywpi 322 18 , , , work_arndyvdyobgtlpeh4rho7pywpi 322 19 Waldrop Waldrop NNP work_arndyvdyobgtlpeh4rho7pywpi 322 20 GL GL NNP work_arndyvdyobgtlpeh4rho7pywpi 322 21 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 322 22 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 322 23 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 322 24 Movement Movement NNP work_arndyvdyobgtlpeh4rho7pywpi 322 25 of of IN work_arndyvdyobgtlpeh4rho7pywpi 322 26 the the DT work_arndyvdyobgtlpeh4rho7pywpi 322 27 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 322 28 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 322 29 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 322 30 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 322 31 domain domain NN work_arndyvdyobgtlpeh4rho7pywpi 322 32 as as IN work_arndyvdyobgtlpeh4rho7pywpi 322 33 a a DT work_arndyvdyobgtlpeh4rho7pywpi 322 34 result result NN work_arndyvdyobgtlpeh4rho7pywpi 322 35 of of IN work_arndyvdyobgtlpeh4rho7pywpi 322 36 ATP atp NN work_arndyvdyobgtlpeh4rho7pywpi 322 37 binding binding NN work_arndyvdyobgtlpeh4rho7pywpi 322 38 . . . work_arndyvdyobgtlpeh4rho7pywpi 323 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 323 2 Biol Biol NNP work_arndyvdyobgtlpeh4rho7pywpi 323 3 Chem Chem NNP work_arndyvdyobgtlpeh4rho7pywpi 323 4 275:16183–16190 275:16183–16190 NNP work_arndyvdyobgtlpeh4rho7pywpi 323 5 Ugarte Ugarte NNP work_arndyvdyobgtlpeh4rho7pywpi 323 6 M M NNP work_arndyvdyobgtlpeh4rho7pywpi 323 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 8 Pérez Pérez NNP work_arndyvdyobgtlpeh4rho7pywpi 323 9 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 323 10 Cerdá Cerdá NNP work_arndyvdyobgtlpeh4rho7pywpi 323 11 C c NN work_arndyvdyobgtlpeh4rho7pywpi 323 12 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 13 Rodrı́guez Rodrı́guez NNP work_arndyvdyobgtlpeh4rho7pywpi 323 14 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 323 15 Pombo Pombo NNP work_arndyvdyobgtlpeh4rho7pywpi 323 16 P P NNP work_arndyvdyobgtlpeh4rho7pywpi 323 17 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 18 Desviat Desviat NNP work_arndyvdyobgtlpeh4rho7pywpi 323 19 LR LR NNP work_arndyvdyobgtlpeh4rho7pywpi 323 20 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 21 Pérez Pérez NFP work_arndyvdyobgtlpeh4rho7pywpi 323 22 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 323 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 24 Richard Richard NNP work_arndyvdyobgtlpeh4rho7pywpi 323 25 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 323 26 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 27 Muro Muro NNP work_arndyvdyobgtlpeh4rho7pywpi 323 28 S S NNP work_arndyvdyobgtlpeh4rho7pywpi 323 29 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 30 Campeau Campeau NNP work_arndyvdyobgtlpeh4rho7pywpi 323 31 E E NNP work_arndyvdyobgtlpeh4rho7pywpi 323 32 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 33 Ohura Ohura NNP work_arndyvdyobgtlpeh4rho7pywpi 323 34 T T NNP work_arndyvdyobgtlpeh4rho7pywpi 323 35 , , , work_arndyvdyobgtlpeh4rho7pywpi 323 36 Gravel Gravel NNP work_arndyvdyobgtlpeh4rho7pywpi 323 37 RA RA NNP work_arndyvdyobgtlpeh4rho7pywpi 323 38 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 323 39 1999 1999 CD work_arndyvdyobgtlpeh4rho7pywpi 323 40 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 323 41 Overview overview NN work_arndyvdyobgtlpeh4rho7pywpi 323 42 of of IN work_arndyvdyobgtlpeh4rho7pywpi 323 43 mutations mutation NNS work_arndyvdyobgtlpeh4rho7pywpi 323 44 in in IN work_arndyvdyobgtlpeh4rho7pywpi 323 45 the the DT work_arndyvdyobgtlpeh4rho7pywpi 323 46 PCCA PCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 323 47 and and CC work_arndyvdyobgtlpeh4rho7pywpi 323 48 PCCB PCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 323 49 genes gene NNS work_arndyvdyobgtlpeh4rho7pywpi 323 50 causing cause VBG work_arndyvdyobgtlpeh4rho7pywpi 323 51 propionic propionic JJ work_arndyvdyobgtlpeh4rho7pywpi 323 52 acidemia acidemia NN work_arndyvdyobgtlpeh4rho7pywpi 323 53 . . . work_arndyvdyobgtlpeh4rho7pywpi 324 1 Hum Hum NNP work_arndyvdyobgtlpeh4rho7pywpi 324 2 Mutat Mutat NNP work_arndyvdyobgtlpeh4rho7pywpi 324 3 14:275–282 14:275–282 CD work_arndyvdyobgtlpeh4rho7pywpi 324 4 van van NNP work_arndyvdyobgtlpeh4rho7pywpi 324 5 Hove Hove NNP work_arndyvdyobgtlpeh4rho7pywpi 324 6 JL JL NNP work_arndyvdyobgtlpeh4rho7pywpi 324 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 324 8 Rutledge Rutledge NNP work_arndyvdyobgtlpeh4rho7pywpi 324 9 SL SL NNP work_arndyvdyobgtlpeh4rho7pywpi 324 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 324 11 Nada Nada NNP work_arndyvdyobgtlpeh4rho7pywpi 324 12 MA MA NNP work_arndyvdyobgtlpeh4rho7pywpi 324 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 324 14 Kahler Kahler NNP work_arndyvdyobgtlpeh4rho7pywpi 324 15 SG SG NNP work_arndyvdyobgtlpeh4rho7pywpi 324 16 , , , work_arndyvdyobgtlpeh4rho7pywpi 324 17 Millington Millington NNP work_arndyvdyobgtlpeh4rho7pywpi 324 18 DS DS NNP work_arndyvdyobgtlpeh4rho7pywpi 324 19 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 324 20 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 324 21 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 324 22 3-Hydroxyisovalerylcarnitine 3-hydroxyisovalerylcarnitine CD work_arndyvdyobgtlpeh4rho7pywpi 324 23 in in IN work_arndyvdyobgtlpeh4rho7pywpi 324 24 3-methylcro- 3-methylcro- NNP work_arndyvdyobgtlpeh4rho7pywpi 324 25 tonyl tonyl NN work_arndyvdyobgtlpeh4rho7pywpi 324 26 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 324 27 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 324 28 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 324 29 deficiency deficiency NN work_arndyvdyobgtlpeh4rho7pywpi 324 30 . . . work_arndyvdyobgtlpeh4rho7pywpi 325 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 325 2 Inherit Inherit NNP work_arndyvdyobgtlpeh4rho7pywpi 325 3 Metab Metab NNP work_arndyvdyobgtlpeh4rho7pywpi 325 4 Dis Dis NNP work_arndyvdyobgtlpeh4rho7pywpi 325 5 18 18 CD work_arndyvdyobgtlpeh4rho7pywpi 325 6 : : : work_arndyvdyobgtlpeh4rho7pywpi 325 7 592–601 592–601 CD work_arndyvdyobgtlpeh4rho7pywpi 325 8 Wahren wahren IN work_arndyvdyobgtlpeh4rho7pywpi 325 9 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 325 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 325 11 Felig Felig NNP work_arndyvdyobgtlpeh4rho7pywpi 325 12 P P NNP work_arndyvdyobgtlpeh4rho7pywpi 325 13 , , , work_arndyvdyobgtlpeh4rho7pywpi 325 14 Hagenfeldt Hagenfeldt NNP work_arndyvdyobgtlpeh4rho7pywpi 325 15 L L NNP work_arndyvdyobgtlpeh4rho7pywpi 325 16 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 325 17 1976 1976 CD work_arndyvdyobgtlpeh4rho7pywpi 325 18 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 325 19 Effect effect NN work_arndyvdyobgtlpeh4rho7pywpi 325 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 325 21 protein protein NN work_arndyvdyobgtlpeh4rho7pywpi 325 22 in- in- JJ work_arndyvdyobgtlpeh4rho7pywpi 325 23 gestion gestion NN work_arndyvdyobgtlpeh4rho7pywpi 325 24 on on IN work_arndyvdyobgtlpeh4rho7pywpi 325 25 splanchic splanchic JJ work_arndyvdyobgtlpeh4rho7pywpi 325 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 325 27 leg leg NN work_arndyvdyobgtlpeh4rho7pywpi 325 28 metabolism metabolism NN work_arndyvdyobgtlpeh4rho7pywpi 325 29 in in IN work_arndyvdyobgtlpeh4rho7pywpi 325 30 normal normal JJ work_arndyvdyobgtlpeh4rho7pywpi 325 31 man man NN work_arndyvdyobgtlpeh4rho7pywpi 325 32 and and CC work_arndyvdyobgtlpeh4rho7pywpi 325 33 in in IN work_arndyvdyobgtlpeh4rho7pywpi 325 34 patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 325 35 with with IN work_arndyvdyobgtlpeh4rho7pywpi 325 36 diabetes diabetes NN work_arndyvdyobgtlpeh4rho7pywpi 325 37 mellitus mellitus NN work_arndyvdyobgtlpeh4rho7pywpi 325 38 . . . work_arndyvdyobgtlpeh4rho7pywpi 326 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 326 2 Clin Clin NNP work_arndyvdyobgtlpeh4rho7pywpi 326 3 Invest Invest NNP work_arndyvdyobgtlpeh4rho7pywpi 326 4 57:987–999 57:987–999 NNP work_arndyvdyobgtlpeh4rho7pywpi 326 5 Waldrop Waldrop NNP work_arndyvdyobgtlpeh4rho7pywpi 326 6 GL GL NNP work_arndyvdyobgtlpeh4rho7pywpi 326 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 326 8 Rayment Rayment NNP work_arndyvdyobgtlpeh4rho7pywpi 326 9 I I NNP work_arndyvdyobgtlpeh4rho7pywpi 326 10 , , , work_arndyvdyobgtlpeh4rho7pywpi 326 11 Holden Holden NNP work_arndyvdyobgtlpeh4rho7pywpi 326 12 HM HM NNP work_arndyvdyobgtlpeh4rho7pywpi 326 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 326 14 1994 1994 CD work_arndyvdyobgtlpeh4rho7pywpi 326 15 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 326 16 Three three CD work_arndyvdyobgtlpeh4rho7pywpi 326 17 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 326 18 dimen- dimen- NN work_arndyvdyobgtlpeh4rho7pywpi 326 19 sional sional JJ work_arndyvdyobgtlpeh4rho7pywpi 326 20 structure structure NN work_arndyvdyobgtlpeh4rho7pywpi 326 21 of of IN work_arndyvdyobgtlpeh4rho7pywpi 326 22 the the DT work_arndyvdyobgtlpeh4rho7pywpi 326 23 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 326 24 carboxylase carboxylase NN work_arndyvdyobgtlpeh4rho7pywpi 326 25 subunit subunit NN work_arndyvdyobgtlpeh4rho7pywpi 326 26 of of IN work_arndyvdyobgtlpeh4rho7pywpi 326 27 acetyl- acetyl- JJ work_arndyvdyobgtlpeh4rho7pywpi 326 28 CoA CoA NNP work_arndyvdyobgtlpeh4rho7pywpi 326 29 carboxylase carboxylase NNP work_arndyvdyobgtlpeh4rho7pywpi 326 30 . . . work_arndyvdyobgtlpeh4rho7pywpi 327 1 Biochemistry Biochemistry NNP work_arndyvdyobgtlpeh4rho7pywpi 327 2 33:10249–10256 33:10249–10256 NNP work_arndyvdyobgtlpeh4rho7pywpi 327 3 Wilcken Wilcken NNP work_arndyvdyobgtlpeh4rho7pywpi 327 4 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 327 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 327 6 Wiley Wiley NNP work_arndyvdyobgtlpeh4rho7pywpi 327 7 V V NNP work_arndyvdyobgtlpeh4rho7pywpi 327 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 327 9 Carpenter Carpenter NNP work_arndyvdyobgtlpeh4rho7pywpi 327 10 K K NNP work_arndyvdyobgtlpeh4rho7pywpi 327 11 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 327 12 2000 2000 CD work_arndyvdyobgtlpeh4rho7pywpi 327 13 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 327 14 Two two CD work_arndyvdyobgtlpeh4rho7pywpi 327 15 years year NNS work_arndyvdyobgtlpeh4rho7pywpi 327 16 of of IN work_arndyvdyobgtlpeh4rho7pywpi 327 17 routine routine JJ work_arndyvdyobgtlpeh4rho7pywpi 327 18 newborn newborn JJ work_arndyvdyobgtlpeh4rho7pywpi 327 19 screening screening NN work_arndyvdyobgtlpeh4rho7pywpi 327 20 by by IN work_arndyvdyobgtlpeh4rho7pywpi 327 21 tandem tandem NNP work_arndyvdyobgtlpeh4rho7pywpi 327 22 mass mass NNP work_arndyvdyobgtlpeh4rho7pywpi 327 23 spectrometry spectrometry NNP work_arndyvdyobgtlpeh4rho7pywpi 327 24 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 327 25 MSMS MSMS NNP work_arndyvdyobgtlpeh4rho7pywpi 327 26 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 327 27 in in IN work_arndyvdyobgtlpeh4rho7pywpi 327 28 New New NNP work_arndyvdyobgtlpeh4rho7pywpi 327 29 South South NNP work_arndyvdyobgtlpeh4rho7pywpi 327 30 Wales Wales NNP work_arndyvdyobgtlpeh4rho7pywpi 327 31 , , , work_arndyvdyobgtlpeh4rho7pywpi 327 32 Australia Australia NNP work_arndyvdyobgtlpeh4rho7pywpi 327 33 . . . work_arndyvdyobgtlpeh4rho7pywpi 328 1 J J NNP work_arndyvdyobgtlpeh4rho7pywpi 328 2 Inherit Inherit NNP work_arndyvdyobgtlpeh4rho7pywpi 328 3 Metab Metab NNP work_arndyvdyobgtlpeh4rho7pywpi 328 4 Dis Dis NNP work_arndyvdyobgtlpeh4rho7pywpi 328 5 23 23 CD work_arndyvdyobgtlpeh4rho7pywpi 328 6 Suppl Suppl NNP work_arndyvdyobgtlpeh4rho7pywpi 328 7 1:007 1:007 CD work_arndyvdyobgtlpeh4rho7pywpi 328 8 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 328 9 poster poster NN work_arndyvdyobgtlpeh4rho7pywpi 328 10 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 328 11 Wolf Wolf NNP work_arndyvdyobgtlpeh4rho7pywpi 328 12 B B NNP work_arndyvdyobgtlpeh4rho7pywpi 328 13 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 328 14 1995 1995 CD work_arndyvdyobgtlpeh4rho7pywpi 328 15 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 328 16 Disorders disorder NNS work_arndyvdyobgtlpeh4rho7pywpi 328 17 of of IN work_arndyvdyobgtlpeh4rho7pywpi 328 18 biotin biotin JJ work_arndyvdyobgtlpeh4rho7pywpi 328 19 metabolism metabolism NN work_arndyvdyobgtlpeh4rho7pywpi 328 20 . . . work_arndyvdyobgtlpeh4rho7pywpi 329 1 In in IN work_arndyvdyobgtlpeh4rho7pywpi 329 2 : : : work_arndyvdyobgtlpeh4rho7pywpi 329 3 Scriver Scriver NNP work_arndyvdyobgtlpeh4rho7pywpi 329 4 C C NNP work_arndyvdyobgtlpeh4rho7pywpi 329 5 , , , work_arndyvdyobgtlpeh4rho7pywpi 329 6 Beaudet Beaudet NNP work_arndyvdyobgtlpeh4rho7pywpi 329 7 A A NNP work_arndyvdyobgtlpeh4rho7pywpi 329 8 , , , work_arndyvdyobgtlpeh4rho7pywpi 329 9 Sly Sly NNP work_arndyvdyobgtlpeh4rho7pywpi 329 10 W W NNP work_arndyvdyobgtlpeh4rho7pywpi 329 11 , , , work_arndyvdyobgtlpeh4rho7pywpi 329 12 Valle Valle NNP work_arndyvdyobgtlpeh4rho7pywpi 329 13 D D NNP work_arndyvdyobgtlpeh4rho7pywpi 329 14 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 329 15 eds eds NNP work_arndyvdyobgtlpeh4rho7pywpi 329 16 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 329 17 The the DT work_arndyvdyobgtlpeh4rho7pywpi 329 18 metabolic metabolic JJ work_arndyvdyobgtlpeh4rho7pywpi 329 19 basis basis NN work_arndyvdyobgtlpeh4rho7pywpi 329 20 of of IN work_arndyvdyobgtlpeh4rho7pywpi 329 21 in- in- JJ work_arndyvdyobgtlpeh4rho7pywpi 329 22 herited herite VBN work_arndyvdyobgtlpeh4rho7pywpi 329 23 disease disease NN work_arndyvdyobgtlpeh4rho7pywpi 329 24 , , , work_arndyvdyobgtlpeh4rho7pywpi 329 25 7th 7th JJ work_arndyvdyobgtlpeh4rho7pywpi 329 26 ed ed NNP work_arndyvdyobgtlpeh4rho7pywpi 329 27 . . . work_arndyvdyobgtlpeh4rho7pywpi 330 1 McGraw McGraw NNP work_arndyvdyobgtlpeh4rho7pywpi 330 2 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 330 3 Hill Hill NNP work_arndyvdyobgtlpeh4rho7pywpi 330 4 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 5 New New NNP work_arndyvdyobgtlpeh4rho7pywpi 330 6 York York NNP work_arndyvdyobgtlpeh4rho7pywpi 330 7 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 8 pp pp XX work_arndyvdyobgtlpeh4rho7pywpi 330 9 3151–3177 3151–3177 CD work_arndyvdyobgtlpeh4rho7pywpi 330 10 The the DT work_arndyvdyobgtlpeh4rho7pywpi 330 11 Molecular Molecular NNP work_arndyvdyobgtlpeh4rho7pywpi 330 12 Basis Basis NNP work_arndyvdyobgtlpeh4rho7pywpi 330 13 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 14 3-Methylcrotonylglycinuria 3-methylcrotonylglycinuria CD work_arndyvdyobgtlpeh4rho7pywpi 330 15 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 16 a a DT work_arndyvdyobgtlpeh4rho7pywpi 330 17 Disorder Disorder NNP work_arndyvdyobgtlpeh4rho7pywpi 330 18 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 19 Leucine Leucine NNP work_arndyvdyobgtlpeh4rho7pywpi 330 20 Catabolism Catabolism NNP work_arndyvdyobgtlpeh4rho7pywpi 330 21 Introduction Introduction NNP work_arndyvdyobgtlpeh4rho7pywpi 330 22 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 23 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 24 Material material NN work_arndyvdyobgtlpeh4rho7pywpi 330 25 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 26 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 27 Methods Methods NNP work_arndyvdyobgtlpeh4rho7pywpi 330 28 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 29 Expressed express VBN work_arndyvdyobgtlpeh4rho7pywpi 330 30 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 330 31 Sequence sequence NN work_arndyvdyobgtlpeh4rho7pywpi 330 32 Tags tag NNS work_arndyvdyobgtlpeh4rho7pywpi 330 33 ( ( -LRB- work_arndyvdyobgtlpeh4rho7pywpi 330 34 ESTs ESTs NNP work_arndyvdyobgtlpeh4rho7pywpi 330 35 ) ) -RRB- work_arndyvdyobgtlpeh4rho7pywpi 330 36 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 37 DNA DNA NNP work_arndyvdyobgtlpeh4rho7pywpi 330 38 Sequencing Sequencing NNP work_arndyvdyobgtlpeh4rho7pywpi 330 39 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 40 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 41 Chromosomal Chromosomal NNP work_arndyvdyobgtlpeh4rho7pywpi 330 42 Localization Localization NNP work_arndyvdyobgtlpeh4rho7pywpi 330 43 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 44 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 330 45 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 46 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 330 47 FISH FISH NNP work_arndyvdyobgtlpeh4rho7pywpi 330 48 Mapping Mapping NNP work_arndyvdyobgtlpeh4rho7pywpi 330 49 Cell Cell NNP work_arndyvdyobgtlpeh4rho7pywpi 330 50 Culture Culture NNP work_arndyvdyobgtlpeh4rho7pywpi 330 51 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 52 Complementation Complementation NNP work_arndyvdyobgtlpeh4rho7pywpi 330 53 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 54 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 55 Biotin Biotin NNP work_arndyvdyobgtlpeh4rho7pywpi 330 56 - - HYPH work_arndyvdyobgtlpeh4rho7pywpi 330 57 Labeling labeling NN work_arndyvdyobgtlpeh4rho7pywpi 330 58 Assays Assays NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 59 Immunohistochemical Immunohistochemical NNP work_arndyvdyobgtlpeh4rho7pywpi 330 60 Localization Localization NNP work_arndyvdyobgtlpeh4rho7pywpi 330 61 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 62 hMCCb hMCCb NNP work_arndyvdyobgtlpeh4rho7pywpi 330 63 in in IN work_arndyvdyobgtlpeh4rho7pywpi 330 64 Mitochondria Mitochondria NNP work_arndyvdyobgtlpeh4rho7pywpi 330 65 Identification Identification NNP work_arndyvdyobgtlpeh4rho7pywpi 330 66 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 67 Mutations Mutations NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 68 in in IN work_arndyvdyobgtlpeh4rho7pywpi 330 69 Patients Patients NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 70 with with IN work_arndyvdyobgtlpeh4rho7pywpi 330 71 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 330 72 Aspergillus Aspergillus NNP work_arndyvdyobgtlpeh4rho7pywpi 330 73 Techniques Techniques NNP work_arndyvdyobgtlpeh4rho7pywpi 330 74 Results Results NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 75 Identification Identification NNP work_arndyvdyobgtlpeh4rho7pywpi 330 76 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 77 Characterization Characterization NNP work_arndyvdyobgtlpeh4rho7pywpi 330 78 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 79 Human Human NNP work_arndyvdyobgtlpeh4rho7pywpi 330 80 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 330 81 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 82 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 330 83 cDNAs cDNAs NNP work_arndyvdyobgtlpeh4rho7pywpi 330 84 Structure Structure NNP work_arndyvdyobgtlpeh4rho7pywpi 330 85 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 86 Chromosomal Chromosomal NNP work_arndyvdyobgtlpeh4rho7pywpi 330 87 Localization Localization NNP work_arndyvdyobgtlpeh4rho7pywpi 330 88 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 89 the the DT work_arndyvdyobgtlpeh4rho7pywpi 330 90 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 330 91 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 92 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 330 93 Genes Genes NNP work_arndyvdyobgtlpeh4rho7pywpi 330 94 Transcription Transcription NNP work_arndyvdyobgtlpeh4rho7pywpi 330 95 Pattern Pattern NNP work_arndyvdyobgtlpeh4rho7pywpi 330 96 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 97 the the DT work_arndyvdyobgtlpeh4rho7pywpi 330 98 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 330 99 and and CC work_arndyvdyobgtlpeh4rho7pywpi 330 100 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 330 101 Genes Genes NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 102 : : : work_arndyvdyobgtlpeh4rho7pywpi 330 103 Agreement agreement NN work_arndyvdyobgtlpeh4rho7pywpi 330 104 with with IN work_arndyvdyobgtlpeh4rho7pywpi 330 105 the the DT work_arndyvdyobgtlpeh4rho7pywpi 330 106 Predicted Predicted NNP work_arndyvdyobgtlpeh4rho7pywpi 330 107 Physiological Physiological NNP work_arndyvdyobgtlpeh4rho7pywpi 330 108 Role Role NNP work_arndyvdyobgtlpeh4rho7pywpi 330 109 Mutations Mutations NNPS work_arndyvdyobgtlpeh4rho7pywpi 330 110 in in IN work_arndyvdyobgtlpeh4rho7pywpi 330 111 MCCA MCCA NNP work_arndyvdyobgtlpeh4rho7pywpi 330 112 or or CC work_arndyvdyobgtlpeh4rho7pywpi 330 113 MCCB MCCB NNP work_arndyvdyobgtlpeh4rho7pywpi 330 114 , , , work_arndyvdyobgtlpeh4rho7pywpi 330 115 in in IN work_arndyvdyobgtlpeh4rho7pywpi 330 116 Patients patient NNS work_arndyvdyobgtlpeh4rho7pywpi 330 117 with with IN work_arndyvdyobgtlpeh4rho7pywpi 330 118 MCG MCG NNP work_arndyvdyobgtlpeh4rho7pywpi 330 119 In in IN work_arndyvdyobgtlpeh4rho7pywpi 330 120 Vivo Vivo NNP work_arndyvdyobgtlpeh4rho7pywpi 330 121 Involvement Involvement NNP work_arndyvdyobgtlpeh4rho7pywpi 330 122 of of IN work_arndyvdyobgtlpeh4rho7pywpi 330 123 MCC MCC NNP work_arndyvdyobgtlpeh4rho7pywpi 330 124 in in IN work_arndyvdyobgtlpeh4rho7pywpi 330 125 Leucine Leucine NNP work_arndyvdyobgtlpeh4rho7pywpi 330 126 Catabolism Catabolism NNP work_arndyvdyobgtlpeh4rho7pywpi 330 127 Discussion Discussion NNP work_arndyvdyobgtlpeh4rho7pywpi 330 128 References References NNPS