id sid tid token lemma pos work_av4lzmkbbzda3hgvpstyfssllm 1 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 1 2 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 1 3 basis basis NN work_av4lzmkbbzda3hgvpstyfssllm 1 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 1 5 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 1 6 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 1 7 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 1 8 CoA coa NN work_av4lzmkbbzda3hgvpstyfssllm 1 9 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 1 10 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 1 11 Matthias Matthias NNP work_av4lzmkbbzda3hgvpstyfssllm 1 12 R. R. NNP work_av4lzmkbbzda3hgvpstyfssllm 1 13 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 1 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 1 15 … … NFP work_av4lzmkbbzda3hgvpstyfssllm 1 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 1 17 E. E. NNP work_av4lzmkbbzda3hgvpstyfssllm 1 18 Regula Regula NNP work_av4lzmkbbzda3hgvpstyfssllm 1 19 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 1 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 1 21 David David NNP work_av4lzmkbbzda3hgvpstyfssllm 1 22 Valle Valle NNP work_av4lzmkbbzda3hgvpstyfssllm 1 23 J J NNP work_av4lzmkbbzda3hgvpstyfssllm 1 24 Clin Clin NNP work_av4lzmkbbzda3hgvpstyfssllm 1 25 Invest Invest NNP work_av4lzmkbbzda3hgvpstyfssllm 1 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 2 1 2001;107(4):495 2001;107(4):495 NNP work_av4lzmkbbzda3hgvpstyfssllm 2 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 2 3 504 504 CD work_av4lzmkbbzda3hgvpstyfssllm 2 4 . . . work_av4lzmkbbzda3hgvpstyfssllm 2 5 https://doi.org/10.1172/JCI11948 https://doi.org/10.1172/jci11948 RB work_av4lzmkbbzda3hgvpstyfssllm 2 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 3 1 Isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 3 2 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 3 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 3 4 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 3 5 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 3 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 3 7 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 3 8 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 3 9 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 3 10 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 3 11 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 3 12 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 3 13 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 3 14 an an DT work_av4lzmkbbzda3hgvpstyfssllm 3 15 autosomal autosomal JJ work_av4lzmkbbzda3hgvpstyfssllm 3 16 recessive recessive JJ work_av4lzmkbbzda3hgvpstyfssllm 3 17 disorder disorder NN work_av4lzmkbbzda3hgvpstyfssllm 3 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 3 19 leucine leucine NN work_av4lzmkbbzda3hgvpstyfssllm 3 20 catabolism catabolism NN work_av4lzmkbbzda3hgvpstyfssllm 3 21 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 3 22 appears appear VBZ work_av4lzmkbbzda3hgvpstyfssllm 3 23 to to TO work_av4lzmkbbzda3hgvpstyfssllm 3 24 be be VB work_av4lzmkbbzda3hgvpstyfssllm 3 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 3 26 most most RBS work_av4lzmkbbzda3hgvpstyfssllm 3 27 frequent frequent JJ work_av4lzmkbbzda3hgvpstyfssllm 3 28 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 3 29 aciduria aciduria NN work_av4lzmkbbzda3hgvpstyfssllm 3 30 detected detect VBD work_av4lzmkbbzda3hgvpstyfssllm 3 31 in in IN work_av4lzmkbbzda3hgvpstyfssllm 3 32 tandem tandem NNP work_av4lzmkbbzda3hgvpstyfssllm 3 33 mass mass NNP work_av4lzmkbbzda3hgvpstyfssllm 3 34 spectrometry spectrometry NNP work_av4lzmkbbzda3hgvpstyfssllm 3 35 – – : work_av4lzmkbbzda3hgvpstyfssllm 3 36 based base VBN work_av4lzmkbbzda3hgvpstyfssllm 3 37 neonatal neonatal JJ work_av4lzmkbbzda3hgvpstyfssllm 3 38 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 3 39 programs program NNS work_av4lzmkbbzda3hgvpstyfssllm 3 40 . . . work_av4lzmkbbzda3hgvpstyfssllm 4 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 4 2 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 4 3 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 4 4 variable variable JJ work_av4lzmkbbzda3hgvpstyfssllm 4 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 4 6 ranging range VBG work_av4lzmkbbzda3hgvpstyfssllm 4 7 from from IN work_av4lzmkbbzda3hgvpstyfssllm 4 8 neonatal neonatal JJ work_av4lzmkbbzda3hgvpstyfssllm 4 9 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 4 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 4 11 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 4 12 neurological neurological JJ work_av4lzmkbbzda3hgvpstyfssllm 4 13 involvement involvement NN work_av4lzmkbbzda3hgvpstyfssllm 4 14 to to IN work_av4lzmkbbzda3hgvpstyfssllm 4 15 asymptomatic asymptomatic JJ work_av4lzmkbbzda3hgvpstyfssllm 4 16 adults adult NNS work_av4lzmkbbzda3hgvpstyfssllm 4 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 5 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 5 2 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 5 3 a a DT work_av4lzmkbbzda3hgvpstyfssllm 5 4 heteromeric heteromeric NN work_av4lzmkbbzda3hgvpstyfssllm 5 5 mitochondrial mitochondrial NN work_av4lzmkbbzda3hgvpstyfssllm 5 6 enzyme enzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 5 7 composed compose VBN work_av4lzmkbbzda3hgvpstyfssllm 5 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 5 9 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 5 10 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 5 11 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 5 12 α α CD work_av4lzmkbbzda3hgvpstyfssllm 5 13 subunits subunit NNS work_av4lzmkbbzda3hgvpstyfssllm 5 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 5 15 smaller small JJR work_av4lzmkbbzda3hgvpstyfssllm 5 16 β β NN work_av4lzmkbbzda3hgvpstyfssllm 5 17 subunits subunit NNS work_av4lzmkbbzda3hgvpstyfssllm 5 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 6 1 Here here RB work_av4lzmkbbzda3hgvpstyfssllm 6 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 6 3 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 6 4 report report VBP work_av4lzmkbbzda3hgvpstyfssllm 6 5 cloning clone VBG work_av4lzmkbbzda3hgvpstyfssllm 6 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 6 7 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 6 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 6 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 6 10 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 6 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 6 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 6 13 organization organization NN work_av4lzmkbbzda3hgvpstyfssllm 6 14 of of IN work_av4lzmkbbzda3hgvpstyfssllm 6 15 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 6 16 structural structural JJ work_av4lzmkbbzda3hgvpstyfssllm 6 17 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 6 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 7 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 7 2 show show VBP work_av4lzmkbbzda3hgvpstyfssllm 7 3 that that IN work_av4lzmkbbzda3hgvpstyfssllm 7 4 a a DT work_av4lzmkbbzda3hgvpstyfssllm 7 5 series series NN work_av4lzmkbbzda3hgvpstyfssllm 7 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 7 7 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 7 8 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 7 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 7 10 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 7 11 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 7 12 defines define VBZ work_av4lzmkbbzda3hgvpstyfssllm 7 13 two two CD work_av4lzmkbbzda3hgvpstyfssllm 7 14 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 7 15 groups group NNS work_av4lzmkbbzda3hgvpstyfssllm 7 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 7 17 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 7 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 7 19 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 7 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 7 21 resulting result VBG work_av4lzmkbbzda3hgvpstyfssllm 7 22 from from IN work_av4lzmkbbzda3hgvpstyfssllm 7 23 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 7 24 in in IN work_av4lzmkbbzda3hgvpstyfssllm 7 25 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 7 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 7 27 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 7 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 7 29 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 7 30 . . . work_av4lzmkbbzda3hgvpstyfssllm 8 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 8 2 identify identify VBP work_av4lzmkbbzda3hgvpstyfssllm 8 3 five five CD work_av4lzmkbbzda3hgvpstyfssllm 8 4 MCCA MCCA NNS work_av4lzmkbbzda3hgvpstyfssllm 8 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 8 6 nine nine CD work_av4lzmkbbzda3hgvpstyfssllm 8 7 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 8 8 mutant mutant NN work_av4lzmkbbzda3hgvpstyfssllm 8 9 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 8 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 8 11 show show VB work_av4lzmkbbzda3hgvpstyfssllm 8 12 that that IN work_av4lzmkbbzda3hgvpstyfssllm 8 13 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 8 14 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 8 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 8 16 each each DT work_av4lzmkbbzda3hgvpstyfssllm 8 17 result result NN work_av4lzmkbbzda3hgvpstyfssllm 8 18 in in IN work_av4lzmkbbzda3hgvpstyfssllm 8 19 loss loss NN work_av4lzmkbbzda3hgvpstyfssllm 8 20 of of IN work_av4lzmkbbzda3hgvpstyfssllm 8 21 function function NN work_av4lzmkbbzda3hgvpstyfssllm 8 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 9 1 Article Article NNP work_av4lzmkbbzda3hgvpstyfssllm 9 2 Find find VBP work_av4lzmkbbzda3hgvpstyfssllm 9 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 9 4 latest late JJS work_av4lzmkbbzda3hgvpstyfssllm 9 5 version version NN work_av4lzmkbbzda3hgvpstyfssllm 9 6 : : : work_av4lzmkbbzda3hgvpstyfssllm 9 7 https://jci.me/11948/pdf https://jci.me/11948/pdf ADD work_av4lzmkbbzda3hgvpstyfssllm 9 8 http://www.jci.org http://www.jci.org NNP work_av4lzmkbbzda3hgvpstyfssllm 9 9 http://www.jci.org/107/4?utm_campaign=cover-page&utm_medium=pdf&utm_source=content http://www.jci.org/107/4?utm_campaign=cover-page&utm_medium=pdf&utm_source=content UH work_av4lzmkbbzda3hgvpstyfssllm 9 10 https://doi.org/10.1172/JCI11948 https://doi.org/10.1172/jci11948 RB work_av4lzmkbbzda3hgvpstyfssllm 9 11 http://www.jci.org/tags/73?utm_campaign=cover-page&utm_medium=pdf&utm_source=content http://www.jci.org/tags/73?utm_campaign=cover-page&utm_medium=pdf&utm_source=content NNP work_av4lzmkbbzda3hgvpstyfssllm 9 12 https://jci.me/11948/pdf https://jci.me/11948/pdf NN work_av4lzmkbbzda3hgvpstyfssllm 9 13 https://jci.me/11948/pdf?utm_content=qrcode https://jci.me/11948/pdf?utm_content=qrcode NFP work_av4lzmkbbzda3hgvpstyfssllm 9 14 Introduction introduction NN work_av4lzmkbbzda3hgvpstyfssllm 9 15 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 9 16 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 9 17 EC EC NNP work_av4lzmkbbzda3hgvpstyfssllm 9 18 6.4.1.4 6.4.1.4 CD work_av4lzmkbbzda3hgvpstyfssllm 9 19 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 9 20 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 9 21 a a DT work_av4lzmkbbzda3hgvpstyfssllm 9 22 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 9 23 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 9 24 dependent dependent JJ work_av4lzmkbbzda3hgvpstyfssllm 9 25 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 9 26 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 9 27 catalyzes catalyze VBZ work_av4lzmkbbzda3hgvpstyfssllm 9 28 the the DT work_av4lzmkbbzda3hgvpstyfssllm 9 29 fourth fourth JJ work_av4lzmkbbzda3hgvpstyfssllm 9 30 step step NN work_av4lzmkbbzda3hgvpstyfssllm 9 31 in in IN work_av4lzmkbbzda3hgvpstyfssllm 9 32 the the DT work_av4lzmkbbzda3hgvpstyfssllm 9 33 leucine leucine NNP work_av4lzmkbbzda3hgvpstyfssllm 9 34 catabolic catabolic NNP work_av4lzmkbbzda3hgvpstyfssllm 9 35 path- path- NNP work_av4lzmkbbzda3hgvpstyfssllm 9 36 way way NN work_av4lzmkbbzda3hgvpstyfssllm 9 37 . . . work_av4lzmkbbzda3hgvpstyfssllm 10 1 Isolated isolated JJ work_av4lzmkbbzda3hgvpstyfssllm 10 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 10 3 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 10 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 10 5 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 10 6 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 10 7 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 10 8 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 10 9 also also RB work_av4lzmkbbzda3hgvpstyfssllm 10 10 known know VBN work_av4lzmkbbzda3hgvpstyfssllm 10 11 as as IN work_av4lzmkbbzda3hgvpstyfssllm 10 12 methylcrotonylglycinuria methylcrotonylglycinuria NNS work_av4lzmkbbzda3hgvpstyfssllm 10 13 [ [ -LRB- work_av4lzmkbbzda3hgvpstyfssllm 10 14 MIM MIM NNP work_av4lzmkbbzda3hgvpstyfssllm 10 15 210200 210200 CD work_av4lzmkbbzda3hgvpstyfssllm 10 16 ] ] -RRB- work_av4lzmkbbzda3hgvpstyfssllm 10 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 10 18 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 10 19 inherited inherit VBN work_av4lzmkbbzda3hgvpstyfssllm 10 20 as as IN work_av4lzmkbbzda3hgvpstyfssllm 10 21 an an DT work_av4lzmkbbzda3hgvpstyfssllm 10 22 autosomal autosomal JJ work_av4lzmkbbzda3hgvpstyfssllm 10 23 recessive recessive JJ work_av4lzmkbbzda3hgvpstyfssllm 10 24 trait trait NN work_av4lzmkbbzda3hgvpstyfssllm 10 25 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 10 26 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 10 27 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 10 28 . . . work_av4lzmkbbzda3hgvpstyfssllm 11 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 11 2 clinical clinical JJ work_av4lzmkbbzda3hgvpstyfssllm 11 3 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 11 4 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 11 5 highly highly RB work_av4lzmkbbzda3hgvpstyfssllm 11 6 variable variable JJ work_av4lzmkbbzda3hgvpstyfssllm 11 7 : : : work_av4lzmkbbzda3hgvpstyfssllm 11 8 some some DT work_av4lzmkbbzda3hgvpstyfssllm 11 9 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 11 10 present present JJ work_av4lzmkbbzda3hgvpstyfssllm 11 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 11 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 11 13 neonatal neonatal JJ work_av4lzmkbbzda3hgvpstyfssllm 11 14 period period NN work_av4lzmkbbzda3hgvpstyfssllm 11 15 with with IN work_av4lzmkbbzda3hgvpstyfssllm 11 16 seizures seizure NNS work_av4lzmkbbzda3hgvpstyfssllm 11 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 11 18 muscular muscular JJ work_av4lzmkbbzda3hgvpstyfssllm 11 19 hypoto- hypoto- NNP work_av4lzmkbbzda3hgvpstyfssllm 11 20 nia nia NNP work_av4lzmkbbzda3hgvpstyfssllm 11 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 11 22 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 11 23 , , , work_av4lzmkbbzda3hgvpstyfssllm 11 24 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 11 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 11 26 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 11 27 others other NNS work_av4lzmkbbzda3hgvpstyfssllm 11 28 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 11 29 asymptomatic asymptomatic JJ work_av4lzmkbbzda3hgvpstyfssllm 11 30 women woman NNS work_av4lzmkbbzda3hgvpstyfssllm 11 31 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 11 32 only only RB work_av4lzmkbbzda3hgvpstyfssllm 11 33 by by IN work_av4lzmkbbzda3hgvpstyfssllm 11 34 detection detection NN work_av4lzmkbbzda3hgvpstyfssllm 11 35 of of IN work_av4lzmkbbzda3hgvpstyfssllm 11 36 abnormal abnormal JJ work_av4lzmkbbzda3hgvpstyfssllm 11 37 metabolites metabolite NNS work_av4lzmkbbzda3hgvpstyfssllm 11 38 in in IN work_av4lzmkbbzda3hgvpstyfssllm 11 39 the the DT work_av4lzmkbbzda3hgvpstyfssllm 11 40 neona- neona- JJ work_av4lzmkbbzda3hgvpstyfssllm 11 41 tal tal NNP work_av4lzmkbbzda3hgvpstyfssllm 11 42 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 11 43 samples sample NNS work_av4lzmkbbzda3hgvpstyfssllm 11 44 of of IN work_av4lzmkbbzda3hgvpstyfssllm 11 45 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 11 46 healthy healthy JJ work_av4lzmkbbzda3hgvpstyfssllm 11 47 babies baby NNS work_av4lzmkbbzda3hgvpstyfssllm 11 48 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 11 49 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 11 50 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 11 51 . . . work_av4lzmkbbzda3hgvpstyfssllm 12 1 There there EX work_av4lzmkbbzda3hgvpstyfssllm 12 2 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 12 3 a a DT work_av4lzmkbbzda3hgvpstyfssllm 12 4 characteristic characteristic JJ work_av4lzmkbbzda3hgvpstyfssllm 12 5 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 12 6 aciduria aciduria NN work_av4lzmkbbzda3hgvpstyfssllm 12 7 with with IN work_av4lzmkbbzda3hgvpstyfssllm 12 8 massive massive JJ work_av4lzmkbbzda3hgvpstyfssllm 12 9 excretion excretion NN work_av4lzmkbbzda3hgvpstyfssllm 12 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 12 11 3-hydroxyisovaleric 3-hydroxyisovaleric CD work_av4lzmkbbzda3hgvpstyfssllm 12 12 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 12 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 12 14 3-methylcrotonylglycine 3-methylcrotonylglycine CD work_av4lzmkbbzda3hgvpstyfssllm 12 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 12 16 usually usually RB work_av4lzmkbbzda3hgvpstyfssllm 12 17 in in IN work_av4lzmkbbzda3hgvpstyfssllm 12 18 combination combination NN work_av4lzmkbbzda3hgvpstyfssllm 12 19 with with IN work_av4lzmkbbzda3hgvpstyfssllm 12 20 a a DT work_av4lzmkbbzda3hgvpstyfssllm 12 21 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 12 22 secondary secondary JJ work_av4lzmkbbzda3hgvpstyfssllm 12 23 carnitine carnitine NN work_av4lzmkbbzda3hgvpstyfssllm 12 24 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 12 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 13 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 13 2 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 13 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 13 4 extracts extract NNS work_av4lzmkbbzda3hgvpstyfssllm 13 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 13 6 cultured cultured JJ work_av4lzmkbbzda3hgvpstyfssllm 13 7 fibrob- fibrob- JJ work_av4lzmkbbzda3hgvpstyfssllm 13 8 lasts last NNS work_av4lzmkbbzda3hgvpstyfssllm 13 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 13 10 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 13 11 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 13 12 usually usually RB work_av4lzmkbbzda3hgvpstyfssllm 13 13 less less JJR work_av4lzmkbbzda3hgvpstyfssllm 13 14 than than IN work_av4lzmkbbzda3hgvpstyfssllm 13 15 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 13 16 % % NN work_av4lzmkbbzda3hgvpstyfssllm 13 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 13 18 control control NN work_av4lzmkbbzda3hgvpstyfssllm 13 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 14 1 No no DT work_av4lzmkbbzda3hgvpstyfssllm 14 2 correlation correlation NN work_av4lzmkbbzda3hgvpstyfssllm 14 3 between between IN work_av4lzmkbbzda3hgvpstyfssllm 14 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 14 5 level level NN work_av4lzmkbbzda3hgvpstyfssllm 14 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 14 7 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 14 8 enzyme enzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 14 9 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 14 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 14 11 clinical clinical JJ work_av4lzmkbbzda3hgvpstyfssllm 14 12 presentation presentation NN work_av4lzmkbbzda3hgvpstyfssllm 14 13 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 14 14 been be VBN work_av4lzmkbbzda3hgvpstyfssllm 14 15 observed observe VBN work_av4lzmkbbzda3hgvpstyfssllm 14 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 15 1 Tandem Tandem NNP work_av4lzmkbbzda3hgvpstyfssllm 15 2 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 15 3 spectrometry spectrometry NN work_av4lzmkbbzda3hgvpstyfssllm 15 4 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 15 5 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 15 6 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 15 7 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 15 8 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 15 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 15 10 recently recently RB work_av4lzmkbbzda3hgvpstyfssllm 15 11 intro- intro- NN work_av4lzmkbbzda3hgvpstyfssllm 15 12 duced duce VBN work_av4lzmkbbzda3hgvpstyfssllm 15 13 for for IN work_av4lzmkbbzda3hgvpstyfssllm 15 14 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 15 15 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 15 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 15 17 provides provide VBZ work_av4lzmkbbzda3hgvpstyfssllm 15 18 for for IN work_av4lzmkbbzda3hgvpstyfssllm 15 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 15 20 first first JJ work_av4lzmkbbzda3hgvpstyfssllm 15 21 time time NN work_av4lzmkbbzda3hgvpstyfssllm 15 22 to to IN work_av4lzmkbbzda3hgvpstyfssllm 15 23 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 15 24 knowledge knowledge NN work_av4lzmkbbzda3hgvpstyfssllm 15 25 a a DT work_av4lzmkbbzda3hgvpstyfssllm 15 26 way way NN work_av4lzmkbbzda3hgvpstyfssllm 15 27 to to TO work_av4lzmkbbzda3hgvpstyfssllm 15 28 detect detect VB work_av4lzmkbbzda3hgvpstyfssllm 15 29 a a DT work_av4lzmkbbzda3hgvpstyfssllm 15 30 large large JJ work_av4lzmkbbzda3hgvpstyfssllm 15 31 variety variety NN work_av4lzmkbbzda3hgvpstyfssllm 15 32 of of IN work_av4lzmkbbzda3hgvpstyfssllm 15 33 organ- organ- NNP work_av4lzmkbbzda3hgvpstyfssllm 15 34 ic ic NNP work_av4lzmkbbzda3hgvpstyfssllm 15 35 acidurias acidurias NNP work_av4lzmkbbzda3hgvpstyfssllm 15 36 including include VBG work_av4lzmkbbzda3hgvpstyfssllm 15 37 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 15 38 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 15 39 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 15 40 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 15 41 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 15 42 . . . work_av4lzmkbbzda3hgvpstyfssllm 16 1 Surprisingly surprisingly RB work_av4lzmkbbzda3hgvpstyfssllm 16 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 16 3 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 16 4 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 16 5 appears appear VBZ work_av4lzmkbbzda3hgvpstyfssllm 16 6 to to TO work_av4lzmkbbzda3hgvpstyfssllm 16 7 be be VB work_av4lzmkbbzda3hgvpstyfssllm 16 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 16 9 most most RBS work_av4lzmkbbzda3hgvpstyfssllm 16 10 frequent frequent JJ work_av4lzmkbbzda3hgvpstyfssllm 16 11 organ- organ- NN work_av4lzmkbbzda3hgvpstyfssllm 16 12 ic ic NNP work_av4lzmkbbzda3hgvpstyfssllm 16 13 aciduria aciduria NNP work_av4lzmkbbzda3hgvpstyfssllm 16 14 detected detect VBD work_av4lzmkbbzda3hgvpstyfssllm 16 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 16 16 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 16 17 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 16 18 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 16 19 screening screen VBG work_av4lzmkbbzda3hgvpstyfssllm 16 20 programs program NNS work_av4lzmkbbzda3hgvpstyfssllm 16 21 in in IN work_av4lzmkbbzda3hgvpstyfssllm 16 22 North North NNP work_av4lzmkbbzda3hgvpstyfssllm 16 23 America America NNP work_av4lzmkbbzda3hgvpstyfssllm 16 24 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 16 25 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 16 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 16 27 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 16 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 16 29 7 7 CD work_av4lzmkbbzda3hgvpstyfssllm 16 30 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 16 31 , , , work_av4lzmkbbzda3hgvpstyfssllm 16 32 Europe Europe NNP work_av4lzmkbbzda3hgvpstyfssllm 16 33 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 16 34 8) 8) CD work_av4lzmkbbzda3hgvpstyfssllm 16 35 , , , work_av4lzmkbbzda3hgvpstyfssllm 16 36 and and CC work_av4lzmkbbzda3hgvpstyfssllm 16 37 Australia Australia NNP work_av4lzmkbbzda3hgvpstyfssllm 16 38 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 16 39 9 9 CD work_av4lzmkbbzda3hgvpstyfssllm 16 40 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 16 41 , , , work_av4lzmkbbzda3hgvpstyfssllm 16 42 with with IN work_av4lzmkbbzda3hgvpstyfssllm 16 43 an an DT work_av4lzmkbbzda3hgvpstyfssllm 16 44 overall overall JJ work_av4lzmkbbzda3hgvpstyfssllm 16 45 frequency frequency NN work_av4lzmkbbzda3hgvpstyfssllm 16 46 of of IN work_av4lzmkbbzda3hgvpstyfssllm 16 47 approximately approximately RB work_av4lzmkbbzda3hgvpstyfssllm 16 48 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 16 49 in in IN work_av4lzmkbbzda3hgvpstyfssllm 16 50 50,000 50,000 CD work_av4lzmkbbzda3hgvpstyfssllm 16 51 . . . work_av4lzmkbbzda3hgvpstyfssllm 17 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 17 2 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 17 3 a a DT work_av4lzmkbbzda3hgvpstyfssllm 17 4 member member NN work_av4lzmkbbzda3hgvpstyfssllm 17 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 17 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 17 7 family family NN work_av4lzmkbbzda3hgvpstyfssllm 17 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 17 9 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 17 10 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 17 11 dependent dependent JJ work_av4lzmkbbzda3hgvpstyfssllm 17 12 carboxylases carboxylase NNS work_av4lzmkbbzda3hgvpstyfssllm 17 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 17 14 a a DT work_av4lzmkbbzda3hgvpstyfssllm 17 15 group group NN work_av4lzmkbbzda3hgvpstyfssllm 17 16 of of IN work_av4lzmkbbzda3hgvpstyfssllm 17 17 enzymes enzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 17 18 with with IN work_av4lzmkbbzda3hgvpstyfssllm 17 19 diverse diverse JJ work_av4lzmkbbzda3hgvpstyfssllm 17 20 meta- meta- JJ work_av4lzmkbbzda3hgvpstyfssllm 17 21 bolic bolic NN work_av4lzmkbbzda3hgvpstyfssllm 17 22 functions function NNS work_av4lzmkbbzda3hgvpstyfssllm 17 23 but but CC work_av4lzmkbbzda3hgvpstyfssllm 17 24 common common JJ work_av4lzmkbbzda3hgvpstyfssllm 17 25 structural structural JJ work_av4lzmkbbzda3hgvpstyfssllm 17 26 features feature NNS work_av4lzmkbbzda3hgvpstyfssllm 17 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 17 28 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 17 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 17 30 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 17 31 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 17 32 . . . work_av4lzmkbbzda3hgvpstyfssllm 18 1 Members member NNS work_av4lzmkbbzda3hgvpstyfssllm 18 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 18 3 this this DT work_av4lzmkbbzda3hgvpstyfssllm 18 4 family family NN work_av4lzmkbbzda3hgvpstyfssllm 18 5 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 18 6 three three CD work_av4lzmkbbzda3hgvpstyfssllm 18 7 structurally structurally RB work_av4lzmkbbzda3hgvpstyfssllm 18 8 con- con- NNP work_av4lzmkbbzda3hgvpstyfssllm 18 9 served serve VBD work_av4lzmkbbzda3hgvpstyfssllm 18 10 functional functional JJ work_av4lzmkbbzda3hgvpstyfssllm 18 11 domains domain NNS work_av4lzmkbbzda3hgvpstyfssllm 18 12 : : : work_av4lzmkbbzda3hgvpstyfssllm 18 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 14 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 18 15 carboxyl carboxyl NN work_av4lzmkbbzda3hgvpstyfssllm 18 16 carrier carrier NN work_av4lzmkbbzda3hgvpstyfssllm 18 17 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 18 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 18 19 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 18 20 carries carry VBZ work_av4lzmkbbzda3hgvpstyfssllm 18 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 22 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 18 23 prosthetic prosthetic JJ work_av4lzmkbbzda3hgvpstyfssllm 18 24 group group NN work_av4lzmkbbzda3hgvpstyfssllm 18 25 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 18 26 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 27 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 18 28 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 18 29 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 18 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 18 31 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 18 32 catalyzes catalyze VBZ work_av4lzmkbbzda3hgvpstyfssllm 18 33 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 34 car- car- NNP work_av4lzmkbbzda3hgvpstyfssllm 18 35 boxylation boxylation NNP work_av4lzmkbbzda3hgvpstyfssllm 18 36 of of IN work_av4lzmkbbzda3hgvpstyfssllm 18 37 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 18 38 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 18 39 and and CC work_av4lzmkbbzda3hgvpstyfssllm 18 40 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 41 carboxyltransferase carboxyltransferase NN work_av4lzmkbbzda3hgvpstyfssllm 18 42 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 18 43 , , , work_av4lzmkbbzda3hgvpstyfssllm 18 44 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 18 45 catalyzes catalyze VBZ work_av4lzmkbbzda3hgvpstyfssllm 18 46 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 47 transfer transfer NN work_av4lzmkbbzda3hgvpstyfssllm 18 48 of of IN work_av4lzmkbbzda3hgvpstyfssllm 18 49 a a DT work_av4lzmkbbzda3hgvpstyfssllm 18 50 carboxyl carboxyl NN work_av4lzmkbbzda3hgvpstyfssllm 18 51 group group NN work_av4lzmkbbzda3hgvpstyfssllm 18 52 from from IN work_av4lzmkbbzda3hgvpstyfssllm 18 53 carboxybiotin carboxybiotin NNP work_av4lzmkbbzda3hgvpstyfssllm 18 54 to to IN work_av4lzmkbbzda3hgvpstyfssllm 18 55 the the DT work_av4lzmkbbzda3hgvpstyfssllm 18 56 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 18 57 substrate substrate NN work_av4lzmkbbzda3hgvpstyfssllm 18 58 spe- spe- NNP work_av4lzmkbbzda3hgvpstyfssllm 18 59 cific cific NN work_av4lzmkbbzda3hgvpstyfssllm 18 60 for for IN work_av4lzmkbbzda3hgvpstyfssllm 18 61 each each DT work_av4lzmkbbzda3hgvpstyfssllm 18 62 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 18 63 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 18 64 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 18 65 , , , work_av4lzmkbbzda3hgvpstyfssllm 18 66 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 18 67 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 18 68 . . . work_av4lzmkbbzda3hgvpstyfssllm 19 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 19 2 addition addition NN work_av4lzmkbbzda3hgvpstyfssllm 19 3 to to IN work_av4lzmkbbzda3hgvpstyfssllm 19 4 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 19 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 19 6 there there EX work_av4lzmkbbzda3hgvpstyfssllm 19 7 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 19 8 three three CD work_av4lzmkbbzda3hgvpstyfssllm 19 9 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 19 10 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 19 11 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 19 12 dependent dependent JJ work_av4lzmkbbzda3hgvpstyfssllm 19 13 carboxylases carboxylase NNS work_av4lzmkbbzda3hgvpstyfssllm 19 14 in in IN work_av4lzmkbbzda3hgvpstyfssllm 19 15 humans human NNS work_av4lzmkbbzda3hgvpstyfssllm 19 16 : : : work_av4lzmkbbzda3hgvpstyfssllm 19 17 propionyl propionyl NN work_av4lzmkbbzda3hgvpstyfssllm 19 18 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 19 19 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 19 20 carboxylase carboxylase NNP work_av4lzmkbbzda3hgvpstyfssllm 19 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 19 22 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 19 23 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 19 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 19 25 pyruvate pyruvate VB work_av4lzmkbbzda3hgvpstyfssllm 19 26 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 19 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 19 28 PC PC NNP work_av4lzmkbbzda3hgvpstyfssllm 19 29 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 19 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 19 31 and and CC work_av4lzmkbbzda3hgvpstyfssllm 19 32 acetyl acetyl NNP work_av4lzmkbbzda3hgvpstyfssllm 19 33 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 19 34 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 19 35 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 19 36 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 19 37 ACC ACC NNP work_av4lzmkbbzda3hgvpstyfssllm 19 38 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 19 39 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 19 40 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 19 41 , , , work_av4lzmkbbzda3hgvpstyfssllm 19 42 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 19 43 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 19 44 . . . work_av4lzmkbbzda3hgvpstyfssllm 20 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 20 2 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 20 3 for for IN work_av4lzmkbbzda3hgvpstyfssllm 20 4 all all DT work_av4lzmkbbzda3hgvpstyfssllm 20 5 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 20 6 carboxylases carboxylase NNS work_av4lzmkbbzda3hgvpstyfssllm 20 7 except except IN work_av4lzmkbbzda3hgvpstyfssllm 20 8 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 20 9 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 20 10 been be VBN work_av4lzmkbbzda3hgvpstyfssllm 20 11 cloned clone VBN work_av4lzmkbbzda3hgvpstyfssllm 20 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 20 13 characterized characterize VBN work_av4lzmkbbzda3hgvpstyfssllm 20 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 20 15 13–15 13–15 NN work_av4lzmkbbzda3hgvpstyfssllm 20 16 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 20 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 21 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 21 2 carboxylates carboxylate VBZ work_av4lzmkbbzda3hgvpstyfssllm 21 3 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 21 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 21 5 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 21 6 at at IN work_av4lzmkbbzda3hgvpstyfssllm 21 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 21 8 4- 4- NNP work_av4lzmkbbzda3hgvpstyfssllm 21 9 carbon carbon NN work_av4lzmkbbzda3hgvpstyfssllm 21 10 to to TO work_av4lzmkbbzda3hgvpstyfssllm 21 11 form form VB work_av4lzmkbbzda3hgvpstyfssllm 21 12 3-methylglutaconyl 3-methylglutaconyl CD work_av4lzmkbbzda3hgvpstyfssllm 21 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 21 14 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 21 15 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 21 16 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 21 17 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 21 18 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 21 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 21 20 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 21 21 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 21 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 22 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 22 2 reaction reaction NN work_av4lzmkbbzda3hgvpstyfssllm 22 3 uses use VBZ work_av4lzmkbbzda3hgvpstyfssllm 22 4 ATP ATP NNP work_av4lzmkbbzda3hgvpstyfssllm 22 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 22 6 bicarbonate bicarbonate NN work_av4lzmkbbzda3hgvpstyfssllm 22 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 22 8 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 22 9 reversible reversible JJ work_av4lzmkbbzda3hgvpstyfssllm 22 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 23 1 Bovine Bovine NNP work_av4lzmkbbzda3hgvpstyfssllm 23 2 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 23 3 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 23 4 an an DT work_av4lzmkbbzda3hgvpstyfssllm 23 5 approximate approximate JJ work_av4lzmkbbzda3hgvpstyfssllm 23 6 size size NN work_av4lzmkbbzda3hgvpstyfssllm 23 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 23 8 835 835 CD work_av4lzmkbbzda3hgvpstyfssllm 23 9 kDa kDa NNS work_av4lzmkbbzda3hgvpstyfssllm 23 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 23 11 appears appear VBZ work_av4lzmkbbzda3hgvpstyfssllm 23 12 to to TO work_av4lzmkbbzda3hgvpstyfssllm 23 13 comprise comprise VB work_av4lzmkbbzda3hgvpstyfssllm 23 14 six six CD work_av4lzmkbbzda3hgvpstyfssllm 23 15 heterodimers heterodimer NNS work_av4lzmkbbzda3hgvpstyfssllm 23 16 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 23 17 αβ)6 αβ)6 NN work_av4lzmkbbzda3hgvpstyfssllm 23 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 23 19 16 16 CD work_av4lzmkbbzda3hgvpstyfssllm 23 20 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 23 21 . . . work_av4lzmkbbzda3hgvpstyfssllm 24 1 Like like IN work_av4lzmkbbzda3hgvpstyfssllm 24 2 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 24 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 24 4 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 24 5 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 24 6 a a DT work_av4lzmkbbzda3hgvpstyfssllm 24 7 larger large JJR work_av4lzmkbbzda3hgvpstyfssllm 24 8 α α CD work_av4lzmkbbzda3hgvpstyfssllm 24 9 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 24 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 24 11 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 24 12 covalently covalently RB work_av4lzmkbbzda3hgvpstyfssllm 24 13 binds bind VBZ work_av4lzmkbbzda3hgvpstyfssllm 24 14 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 24 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 24 16 and and CC work_av4lzmkbbzda3hgvpstyfssllm 24 17 a a DT work_av4lzmkbbzda3hgvpstyfssllm 24 18 smaller small JJR work_av4lzmkbbzda3hgvpstyfssllm 24 19 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 24 20 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 24 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 24 22 13 13 CD work_av4lzmkbbzda3hgvpstyfssllm 24 23 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 24 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 25 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 25 2 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 25 3 predominantly predominantly RB work_av4lzmkbbzda3hgvpstyfssllm 25 4 localized localize VBN work_av4lzmkbbzda3hgvpstyfssllm 25 5 to to IN work_av4lzmkbbzda3hgvpstyfssllm 25 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 25 7 inner inner JJ work_av4lzmkbbzda3hgvpstyfssllm 25 8 mem- mem- NNP work_av4lzmkbbzda3hgvpstyfssllm 25 9 brane brane NN work_av4lzmkbbzda3hgvpstyfssllm 25 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 25 11 mitochondria mitochondria NNP work_av4lzmkbbzda3hgvpstyfssllm 25 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 25 13 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 25 14 known know VBN work_av4lzmkbbzda3hgvpstyfssllm 25 15 to to TO work_av4lzmkbbzda3hgvpstyfssllm 25 16 be be VB work_av4lzmkbbzda3hgvpstyfssllm 25 17 highly highly RB work_av4lzmkbbzda3hgvpstyfssllm 25 18 expressed express VBN work_av4lzmkbbzda3hgvpstyfssllm 25 19 in in IN work_av4lzmkbbzda3hgvpstyfssllm 25 20 kidney kidney NN work_av4lzmkbbzda3hgvpstyfssllm 25 21 and and CC work_av4lzmkbbzda3hgvpstyfssllm 25 22 liver liver NN work_av4lzmkbbzda3hgvpstyfssllm 25 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 25 24 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 25 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 25 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 26 1 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 26 2 encoding encode VBG work_av4lzmkbbzda3hgvpstyfssllm 26 3 both both DT work_av4lzmkbbzda3hgvpstyfssllm 26 4 subunits subunit NNS work_av4lzmkbbzda3hgvpstyfssllm 26 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 26 6 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 26 7 recently recently RB work_av4lzmkbbzda3hgvpstyfssllm 26 8 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 26 9 been be VBN work_av4lzmkbbzda3hgvpstyfssllm 26 10 cloned clone VBN work_av4lzmkbbzda3hgvpstyfssllm 26 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 26 12 Ara- Ara- NNP work_av4lzmkbbzda3hgvpstyfssllm 26 13 bidopsis bidopsis NN work_av4lzmkbbzda3hgvpstyfssllm 26 14 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 26 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 26 16 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 26 17 plants plant NNS work_av4lzmkbbzda3hgvpstyfssllm 26 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 26 19 17 17 CD work_av4lzmkbbzda3hgvpstyfssllm 26 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 26 21 18 18 CD work_av4lzmkbbzda3hgvpstyfssllm 26 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 26 23 . . . work_av4lzmkbbzda3hgvpstyfssllm 27 1 Here here RB work_av4lzmkbbzda3hgvpstyfssllm 27 2 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 27 3 report report VBP work_av4lzmkbbzda3hgvpstyfssllm 27 4 cloning clone VBG work_av4lzmkbbzda3hgvpstyfssllm 27 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 27 6 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 27 7 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 27 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 27 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 27 10 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 27 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 27 12 confirmation confirmation NN work_av4lzmkbbzda3hgvpstyfssllm 27 13 of of IN work_av4lzmkbbzda3hgvpstyfssllm 27 14 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 27 15 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 27 16 by by IN work_av4lzmkbbzda3hgvpstyfssllm 27 17 biochemical biochemical JJ work_av4lzmkbbzda3hgvpstyfssllm 27 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 27 19 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 27 20 studies study NNS work_av4lzmkbbzda3hgvpstyfssllm 27 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 27 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 27 23 identification identification NN work_av4lzmkbbzda3hgvpstyfssllm 27 24 of of IN work_av4lzmkbbzda3hgvpstyfssllm 27 25 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 27 26 in in IN work_av4lzmkbbzda3hgvpstyfssllm 27 27 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 27 28 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 27 29 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 27 30 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 27 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 28 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 28 2 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 28 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 4 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 28 5 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 28 6 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 28 7 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 28 8 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 28 9 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 28 10 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 28 11 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 28 12 | | CD work_av4lzmkbbzda3hgvpstyfssllm 28 13 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 28 14 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 28 15 495 495 CD work_av4lzmkbbzda3hgvpstyfssllm 28 16 The the DT work_av4lzmkbbzda3hgvpstyfssllm 28 17 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 28 18 basis basis NN work_av4lzmkbbzda3hgvpstyfssllm 28 19 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 20 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 28 21 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 28 22 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 28 23 CoA coa NN work_av4lzmkbbzda3hgvpstyfssllm 28 24 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 28 25 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 28 26 Matthias Matthias NNP work_av4lzmkbbzda3hgvpstyfssllm 28 27 R. R. NNP work_av4lzmkbbzda3hgvpstyfssllm 28 28 Baumgartner,1,2 Baumgartner,1,2 NNP work_av4lzmkbbzda3hgvpstyfssllm 28 29 Shlomo Shlomo NNP work_av4lzmkbbzda3hgvpstyfssllm 28 30 Almashanu,1,3 Almashanu,1,3 NNP work_av4lzmkbbzda3hgvpstyfssllm 28 31 Terttu Terttu NNP work_av4lzmkbbzda3hgvpstyfssllm 28 32 Suormala,2 Suormala,2 NNP work_av4lzmkbbzda3hgvpstyfssllm 28 33 Cassandra Cassandra NNP work_av4lzmkbbzda3hgvpstyfssllm 28 34 Obie,1,3 obie,1,3 ADD work_av4lzmkbbzda3hgvpstyfssllm 28 35 Robert Robert NNP work_av4lzmkbbzda3hgvpstyfssllm 28 36 N. N. NNP work_av4lzmkbbzda3hgvpstyfssllm 28 37 Cole,4 Cole,4 NNP work_av4lzmkbbzda3hgvpstyfssllm 28 38 Seymour Seymour NNP work_av4lzmkbbzda3hgvpstyfssllm 28 39 Packman,5 Packman,5 NNP work_av4lzmkbbzda3hgvpstyfssllm 28 40 E. E. NNP work_av4lzmkbbzda3hgvpstyfssllm 28 41 Regula Regula NNP work_av4lzmkbbzda3hgvpstyfssllm 28 42 Baumgartner,2 Baumgartner,2 NNP work_av4lzmkbbzda3hgvpstyfssllm 28 43 and and CC work_av4lzmkbbzda3hgvpstyfssllm 28 44 David David NNP work_av4lzmkbbzda3hgvpstyfssllm 28 45 Valle1,3 valle1,3 CD work_av4lzmkbbzda3hgvpstyfssllm 28 46 1McKusick 1mckusick CD work_av4lzmkbbzda3hgvpstyfssllm 28 47 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 28 48 Nathans Nathans NNP work_av4lzmkbbzda3hgvpstyfssllm 28 49 Institute Institute NNP work_av4lzmkbbzda3hgvpstyfssllm 28 50 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 51 Genetic Genetic NNP work_av4lzmkbbzda3hgvpstyfssllm 28 52 Medicine Medicine NNP work_av4lzmkbbzda3hgvpstyfssllm 28 53 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 54 Johns Johns NNP work_av4lzmkbbzda3hgvpstyfssllm 28 55 Hopkins Hopkins NNP work_av4lzmkbbzda3hgvpstyfssllm 28 56 University University NNP work_av4lzmkbbzda3hgvpstyfssllm 28 57 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 58 Baltimore Baltimore NNP work_av4lzmkbbzda3hgvpstyfssllm 28 59 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 60 Maryland Maryland NNP work_av4lzmkbbzda3hgvpstyfssllm 28 61 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 62 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 28 63 2Metabolic 2Metabolic NNP work_av4lzmkbbzda3hgvpstyfssllm 28 64 Unit Unit NNP work_av4lzmkbbzda3hgvpstyfssllm 28 65 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 66 Children Children NNP work_av4lzmkbbzda3hgvpstyfssllm 28 67 ’s ’s POS work_av4lzmkbbzda3hgvpstyfssllm 28 68 Hospital Hospital NNP work_av4lzmkbbzda3hgvpstyfssllm 28 69 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 70 University University NNP work_av4lzmkbbzda3hgvpstyfssllm 28 71 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 72 Basel Basel NNP work_av4lzmkbbzda3hgvpstyfssllm 28 73 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 74 Basel Basel NNP work_av4lzmkbbzda3hgvpstyfssllm 28 75 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 76 Switzerland Switzerland NNP work_av4lzmkbbzda3hgvpstyfssllm 28 77 3Howard 3Howard NNP work_av4lzmkbbzda3hgvpstyfssllm 28 78 Hughes Hughes NNP work_av4lzmkbbzda3hgvpstyfssllm 28 79 Medical Medical NNP work_av4lzmkbbzda3hgvpstyfssllm 28 80 Institute Institute NNP work_av4lzmkbbzda3hgvpstyfssllm 28 81 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 82 and and CC work_av4lzmkbbzda3hgvpstyfssllm 28 83 4Department 4department NN work_av4lzmkbbzda3hgvpstyfssllm 28 84 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 85 Biological Biological NNP work_av4lzmkbbzda3hgvpstyfssllm 28 86 Chemistry Chemistry NNP work_av4lzmkbbzda3hgvpstyfssllm 28 87 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 88 Johns Johns NNP work_av4lzmkbbzda3hgvpstyfssllm 28 89 Hopkins Hopkins NNP work_av4lzmkbbzda3hgvpstyfssllm 28 90 University University NNP work_av4lzmkbbzda3hgvpstyfssllm 28 91 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 92 Baltimore Baltimore NNP work_av4lzmkbbzda3hgvpstyfssllm 28 93 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 94 Maryland Maryland NNP work_av4lzmkbbzda3hgvpstyfssllm 28 95 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 96 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 28 97 5Department 5department CD work_av4lzmkbbzda3hgvpstyfssllm 28 98 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 99 Pediatrics Pediatrics NNP work_av4lzmkbbzda3hgvpstyfssllm 28 100 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 101 University University NNP work_av4lzmkbbzda3hgvpstyfssllm 28 102 of of IN work_av4lzmkbbzda3hgvpstyfssllm 28 103 California California NNP work_av4lzmkbbzda3hgvpstyfssllm 28 104 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 105 San San NNP work_av4lzmkbbzda3hgvpstyfssllm 28 106 Francisco Francisco NNP work_av4lzmkbbzda3hgvpstyfssllm 28 107 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 108 California California NNP work_av4lzmkbbzda3hgvpstyfssllm 28 109 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 110 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 28 111 Address Address NNP work_av4lzmkbbzda3hgvpstyfssllm 28 112 correspondence correspondence NN work_av4lzmkbbzda3hgvpstyfssllm 28 113 to to IN work_av4lzmkbbzda3hgvpstyfssllm 28 114 : : : work_av4lzmkbbzda3hgvpstyfssllm 28 115 David David NNP work_av4lzmkbbzda3hgvpstyfssllm 28 116 Valle Valle NNP work_av4lzmkbbzda3hgvpstyfssllm 28 117 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 118 802 802 CD work_av4lzmkbbzda3hgvpstyfssllm 28 119 PCTB PCTB NNP work_av4lzmkbbzda3hgvpstyfssllm 28 120 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 121 Johns Johns NNP work_av4lzmkbbzda3hgvpstyfssllm 28 122 Hopkins Hopkins NNP work_av4lzmkbbzda3hgvpstyfssllm 28 123 University University NNP work_av4lzmkbbzda3hgvpstyfssllm 28 124 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 125 725 725 CD work_av4lzmkbbzda3hgvpstyfssllm 28 126 N. N. NNP work_av4lzmkbbzda3hgvpstyfssllm 28 127 Wolfe Wolfe NNP work_av4lzmkbbzda3hgvpstyfssllm 28 128 Street Street NNP work_av4lzmkbbzda3hgvpstyfssllm 28 129 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 130 Baltimore Baltimore NNP work_av4lzmkbbzda3hgvpstyfssllm 28 131 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 132 Maryland Maryland NNP work_av4lzmkbbzda3hgvpstyfssllm 28 133 21205 21205 CD work_av4lzmkbbzda3hgvpstyfssllm 28 134 , , , work_av4lzmkbbzda3hgvpstyfssllm 28 135 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 28 136 . . . work_av4lzmkbbzda3hgvpstyfssllm 29 1 Phone phone NN work_av4lzmkbbzda3hgvpstyfssllm 29 2 : : : work_av4lzmkbbzda3hgvpstyfssllm 29 3 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 29 4 410 410 CD work_av4lzmkbbzda3hgvpstyfssllm 29 5 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 29 6 955 955 CD work_av4lzmkbbzda3hgvpstyfssllm 29 7 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 29 8 4260 4260 CD work_av4lzmkbbzda3hgvpstyfssllm 29 9 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 29 10 Fax fax NN work_av4lzmkbbzda3hgvpstyfssllm 29 11 : : : work_av4lzmkbbzda3hgvpstyfssllm 29 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 29 13 410 410 CD work_av4lzmkbbzda3hgvpstyfssllm 29 14 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 29 15 955 955 CD work_av4lzmkbbzda3hgvpstyfssllm 29 16 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 29 17 7397 7397 CD work_av4lzmkbbzda3hgvpstyfssllm 29 18 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 29 19 E e NN work_av4lzmkbbzda3hgvpstyfssllm 29 20 - - NN work_av4lzmkbbzda3hgvpstyfssllm 29 21 mail mail NN work_av4lzmkbbzda3hgvpstyfssllm 29 22 : : : work_av4lzmkbbzda3hgvpstyfssllm 29 23 dvalle@jhmi.edu dvalle@jhmi.edu ADD work_av4lzmkbbzda3hgvpstyfssllm 29 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 30 1 Received receive VBN work_av4lzmkbbzda3hgvpstyfssllm 30 2 for for IN work_av4lzmkbbzda3hgvpstyfssllm 30 3 publication publication NN work_av4lzmkbbzda3hgvpstyfssllm 30 4 December December NNP work_av4lzmkbbzda3hgvpstyfssllm 30 5 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 30 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 30 7 2000 2000 CD work_av4lzmkbbzda3hgvpstyfssllm 30 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 30 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 30 10 accepted accept VBN work_av4lzmkbbzda3hgvpstyfssllm 30 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 30 12 revised revise VBN work_av4lzmkbbzda3hgvpstyfssllm 30 13 form form NN work_av4lzmkbbzda3hgvpstyfssllm 30 14 January January NNP work_av4lzmkbbzda3hgvpstyfssllm 30 15 7 7 CD work_av4lzmkbbzda3hgvpstyfssllm 30 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 30 17 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 30 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 31 1 Isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 31 2 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 31 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 31 4 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 31 5 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 31 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 31 7 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 31 8 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 31 9 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 31 10 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 31 11 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 31 12 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 31 13 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 31 14 an an DT work_av4lzmkbbzda3hgvpstyfssllm 31 15 autosomal autosomal JJ work_av4lzmkbbzda3hgvpstyfssllm 31 16 recessive recessive JJ work_av4lzmkbbzda3hgvpstyfssllm 31 17 disorder disorder NN work_av4lzmkbbzda3hgvpstyfssllm 31 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 31 19 leucine leucine NN work_av4lzmkbbzda3hgvpstyfssllm 31 20 catabolism catabolism NN work_av4lzmkbbzda3hgvpstyfssllm 31 21 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 31 22 appears appear VBZ work_av4lzmkbbzda3hgvpstyfssllm 31 23 to to TO work_av4lzmkbbzda3hgvpstyfssllm 31 24 be be VB work_av4lzmkbbzda3hgvpstyfssllm 31 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 31 26 most most RBS work_av4lzmkbbzda3hgvpstyfssllm 31 27 frequent frequent JJ work_av4lzmkbbzda3hgvpstyfssllm 31 28 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 31 29 aciduria aciduria NN work_av4lzmkbbzda3hgvpstyfssllm 31 30 detected detect VBD work_av4lzmkbbzda3hgvpstyfssllm 31 31 in in IN work_av4lzmkbbzda3hgvpstyfssllm 31 32 tandem tandem NNP work_av4lzmkbbzda3hgvpstyfssllm 31 33 mass mass NNP work_av4lzmkbbzda3hgvpstyfssllm 31 34 spectrometry spectrometry NNP work_av4lzmkbbzda3hgvpstyfssllm 31 35 – – : work_av4lzmkbbzda3hgvpstyfssllm 31 36 based base VBN work_av4lzmkbbzda3hgvpstyfssllm 31 37 neonatal neonatal JJ work_av4lzmkbbzda3hgvpstyfssllm 31 38 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 31 39 programs program NNS work_av4lzmkbbzda3hgvpstyfssllm 31 40 . . . work_av4lzmkbbzda3hgvpstyfssllm 32 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 32 2 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 32 3 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 32 4 variable variable JJ work_av4lzmkbbzda3hgvpstyfssllm 32 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 32 6 ranging range VBG work_av4lzmkbbzda3hgvpstyfssllm 32 7 from from IN work_av4lzmkbbzda3hgvpstyfssllm 32 8 neonatal neonatal JJ work_av4lzmkbbzda3hgvpstyfssllm 32 9 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 32 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 32 11 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 32 12 neurological neurological JJ work_av4lzmkbbzda3hgvpstyfssllm 32 13 involvement involvement NN work_av4lzmkbbzda3hgvpstyfssllm 32 14 to to IN work_av4lzmkbbzda3hgvpstyfssllm 32 15 asymptomatic asymptomatic JJ work_av4lzmkbbzda3hgvpstyfssllm 32 16 adults adult NNS work_av4lzmkbbzda3hgvpstyfssllm 32 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 33 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 33 2 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 33 3 a a DT work_av4lzmkbbzda3hgvpstyfssllm 33 4 heteromeric heteromeric NN work_av4lzmkbbzda3hgvpstyfssllm 33 5 mitochondrial mitochondrial NN work_av4lzmkbbzda3hgvpstyfssllm 33 6 enzyme enzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 33 7 composed compose VBN work_av4lzmkbbzda3hgvpstyfssllm 33 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 33 9 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 33 10 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 33 11 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 33 12 α α CD work_av4lzmkbbzda3hgvpstyfssllm 33 13 subunits subunit NNS work_av4lzmkbbzda3hgvpstyfssllm 33 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 33 15 smaller small JJR work_av4lzmkbbzda3hgvpstyfssllm 33 16 β β NN work_av4lzmkbbzda3hgvpstyfssllm 33 17 subunits subunit NNS work_av4lzmkbbzda3hgvpstyfssllm 33 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 34 1 Here here RB work_av4lzmkbbzda3hgvpstyfssllm 34 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 34 3 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 34 4 report report VBP work_av4lzmkbbzda3hgvpstyfssllm 34 5 cloning clone VBG work_av4lzmkbbzda3hgvpstyfssllm 34 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 34 7 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 34 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 34 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 34 10 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 34 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 34 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 34 13 organiza- organiza- JJ work_av4lzmkbbzda3hgvpstyfssllm 34 14 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 34 15 of of IN work_av4lzmkbbzda3hgvpstyfssllm 34 16 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 34 17 structural structural JJ work_av4lzmkbbzda3hgvpstyfssllm 34 18 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 34 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 35 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 35 2 show show VBP work_av4lzmkbbzda3hgvpstyfssllm 35 3 that that IN work_av4lzmkbbzda3hgvpstyfssllm 35 4 a a DT work_av4lzmkbbzda3hgvpstyfssllm 35 5 series series NN work_av4lzmkbbzda3hgvpstyfssllm 35 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 35 7 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 35 8 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 35 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 35 10 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 35 11 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 35 12 defines define VBZ work_av4lzmkbbzda3hgvpstyfssllm 35 13 two two CD work_av4lzmkbbzda3hgvpstyfssllm 35 14 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 35 15 groups group NNS work_av4lzmkbbzda3hgvpstyfssllm 35 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 35 17 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 35 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 35 19 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 35 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 35 21 resulting result VBG work_av4lzmkbbzda3hgvpstyfssllm 35 22 from from IN work_av4lzmkbbzda3hgvpstyfssllm 35 23 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 35 24 in in IN work_av4lzmkbbzda3hgvpstyfssllm 35 25 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 35 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 35 27 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 35 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 35 29 respective- respective- XX work_av4lzmkbbzda3hgvpstyfssllm 35 30 ly ly XX work_av4lzmkbbzda3hgvpstyfssllm 35 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 36 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 36 2 identify identify VBP work_av4lzmkbbzda3hgvpstyfssllm 36 3 five five CD work_av4lzmkbbzda3hgvpstyfssllm 36 4 MCCA MCCA NNS work_av4lzmkbbzda3hgvpstyfssllm 36 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 36 6 nine nine CD work_av4lzmkbbzda3hgvpstyfssllm 36 7 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 36 8 mutant mutant NN work_av4lzmkbbzda3hgvpstyfssllm 36 9 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 36 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 36 11 show show VB work_av4lzmkbbzda3hgvpstyfssllm 36 12 that that IN work_av4lzmkbbzda3hgvpstyfssllm 36 13 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 36 14 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 36 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 36 16 each each DT work_av4lzmkbbzda3hgvpstyfssllm 36 17 result result NN work_av4lzmkbbzda3hgvpstyfssllm 36 18 in in IN work_av4lzmkbbzda3hgvpstyfssllm 36 19 loss loss NN work_av4lzmkbbzda3hgvpstyfssllm 36 20 of of IN work_av4lzmkbbzda3hgvpstyfssllm 36 21 function function NN work_av4lzmkbbzda3hgvpstyfssllm 36 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 37 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 37 2 Clin Clin NNP work_av4lzmkbbzda3hgvpstyfssllm 37 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 38 1 Invest invest VB work_av4lzmkbbzda3hgvpstyfssllm 38 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 39 1 107:495–504 107:495–504 CD work_av4lzmkbbzda3hgvpstyfssllm 39 2 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 39 3 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 39 4 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 39 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 40 1 496 496 CD work_av4lzmkbbzda3hgvpstyfssllm 40 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 40 3 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 40 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 40 5 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 40 6 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 40 7 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 40 8 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 40 9 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 40 10 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 40 11 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 40 12 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 40 13 | | CD work_av4lzmkbbzda3hgvpstyfssllm 40 14 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 40 15 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 40 16 Methods Methods NNPS work_av4lzmkbbzda3hgvpstyfssllm 40 17 Patients Patients NNPS work_av4lzmkbbzda3hgvpstyfssllm 40 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 40 19 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 40 20 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 40 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 40 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 40 23 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 40 24 assay assay NNP work_av4lzmkbbzda3hgvpstyfssllm 40 25 This this DT work_av4lzmkbbzda3hgvpstyfssllm 40 26 study study NN work_av4lzmkbbzda3hgvpstyfssllm 40 27 includes include VBZ work_av4lzmkbbzda3hgvpstyfssllm 40 28 16 16 CD work_av4lzmkbbzda3hgvpstyfssllm 40 29 MCC mcc NN work_av4lzmkbbzda3hgvpstyfssllm 40 30 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 40 31 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 40 32 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 40 33 , , , work_av4lzmkbbzda3hgvpstyfssllm 40 34 all all DT work_av4lzmkbbzda3hgvpstyfssllm 40 35 of of IN work_av4lzmkbbzda3hgvpstyfssllm 40 36 whom whom WP work_av4lzmkbbzda3hgvpstyfssllm 40 37 had have VBD work_av4lzmkbbzda3hgvpstyfssllm 40 38 the the DT work_av4lzmkbbzda3hgvpstyfssllm 40 39 diagnostic diagnostic JJ work_av4lzmkbbzda3hgvpstyfssllm 40 40 pattern pattern NN work_av4lzmkbbzda3hgvpstyfssllm 40 41 of of IN work_av4lzmkbbzda3hgvpstyfssllm 40 42 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 40 43 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 40 44 excre- excre- NNP work_av4lzmkbbzda3hgvpstyfssllm 40 45 tion tion NNP work_av4lzmkbbzda3hgvpstyfssllm 40 46 and and CC work_av4lzmkbbzda3hgvpstyfssllm 40 47 less less JJR work_av4lzmkbbzda3hgvpstyfssllm 40 48 than than IN work_av4lzmkbbzda3hgvpstyfssllm 40 49 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 40 50 % % NN work_av4lzmkbbzda3hgvpstyfssllm 40 51 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 40 52 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 40 53 in in IN work_av4lzmkbbzda3hgvpstyfssllm 40 54 extracts extract NNS work_av4lzmkbbzda3hgvpstyfssllm 40 55 of of IN work_av4lzmkbbzda3hgvpstyfssllm 40 56 cul- cul- RB work_av4lzmkbbzda3hgvpstyfssllm 40 57 tured ture VBN work_av4lzmkbbzda3hgvpstyfssllm 40 58 skin skin NN work_av4lzmkbbzda3hgvpstyfssllm 40 59 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 40 60 . . . work_av4lzmkbbzda3hgvpstyfssllm 41 1 Clinical clinical JJ work_av4lzmkbbzda3hgvpstyfssllm 41 2 and and CC work_av4lzmkbbzda3hgvpstyfssllm 41 3 biochemical biochemical JJ work_av4lzmkbbzda3hgvpstyfssllm 41 4 data datum NNS work_av4lzmkbbzda3hgvpstyfssllm 41 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 41 6 ten ten CD work_av4lzmkbbzda3hgvpstyfssllm 41 7 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 41 8 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 41 9 been be VBN work_av4lzmkbbzda3hgvpstyfssllm 41 10 reported report VBN work_av4lzmkbbzda3hgvpstyfssllm 41 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 41 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 41 13 literature literature NN work_av4lzmkbbzda3hgvpstyfssllm 41 14 : : : work_av4lzmkbbzda3hgvpstyfssllm 41 15 001 001 CD work_av4lzmkbbzda3hgvpstyfssllm 41 16 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 17 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 41 18 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 20 002 002 CD work_av4lzmkbbzda3hgvpstyfssllm 41 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 22 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 41 23 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 25 003 003 NNP work_av4lzmkbbzda3hgvpstyfssllm 41 26 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 27 19 19 CD work_av4lzmkbbzda3hgvpstyfssllm 41 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 30 004 004 CD work_av4lzmkbbzda3hgvpstyfssllm 41 31 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 32 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 41 33 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 34 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 35 006 006 CD work_av4lzmkbbzda3hgvpstyfssllm 41 36 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 37 21 21 CD work_av4lzmkbbzda3hgvpstyfssllm 41 38 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 39 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 40 007 007 CD work_av4lzmkbbzda3hgvpstyfssllm 41 41 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 42 22 22 CD work_av4lzmkbbzda3hgvpstyfssllm 41 43 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 44 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 45 010 010 CD work_av4lzmkbbzda3hgvpstyfssllm 41 46 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 47 23 23 CD work_av4lzmkbbzda3hgvpstyfssllm 41 48 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 49 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 50 011 011 CD work_av4lzmkbbzda3hgvpstyfssllm 41 51 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 52 24 24 CD work_av4lzmkbbzda3hgvpstyfssllm 41 53 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 54 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 55 012 012 CD work_av4lzmkbbzda3hgvpstyfssllm 41 56 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 57 25 25 CD work_av4lzmkbbzda3hgvpstyfssllm 41 58 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 59 , , , work_av4lzmkbbzda3hgvpstyfssllm 41 60 and and CC work_av4lzmkbbzda3hgvpstyfssllm 41 61 016 016 CD work_av4lzmkbbzda3hgvpstyfssllm 41 62 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 41 63 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 41 64 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 41 65 . . . work_av4lzmkbbzda3hgvpstyfssllm 42 1 Fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 42 2 or or CC work_av4lzmkbbzda3hgvpstyfssllm 42 3 DNA dna NN work_av4lzmkbbzda3hgvpstyfssllm 42 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 42 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 42 6 remaining remain VBG work_av4lzmkbbzda3hgvpstyfssllm 42 7 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 42 8 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 42 9 referred refer VBN work_av4lzmkbbzda3hgvpstyfssllm 42 10 by by IN work_av4lzmkbbzda3hgvpstyfssllm 42 11 B.T. B.T. NNP work_av4lzmkbbzda3hgvpstyfssllm 43 1 Poll Poll NNP work_av4lzmkbbzda3hgvpstyfssllm 43 2 - - . work_av4lzmkbbzda3hgvpstyfssllm 43 3 The the DT work_av4lzmkbbzda3hgvpstyfssllm 43 4 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 43 5 patient patient JJ work_av4lzmkbbzda3hgvpstyfssllm 43 6 005 005 CD work_av4lzmkbbzda3hgvpstyfssllm 43 7 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 43 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 43 9 H.G. H.G. NNP work_av4lzmkbbzda3hgvpstyfssllm 44 1 Koch Koch NNP work_av4lzmkbbzda3hgvpstyfssllm 44 2 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 44 3 patient patient JJ work_av4lzmkbbzda3hgvpstyfssllm 44 4 008 008 CD work_av4lzmkbbzda3hgvpstyfssllm 44 5 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 44 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 44 7 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 44 8 Smeitink Smeitink NNP work_av4lzmkbbzda3hgvpstyfssllm 44 9 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 44 10 patient patient JJ work_av4lzmkbbzda3hgvpstyfssllm 44 11 009 009 CD work_av4lzmkbbzda3hgvpstyfssllm 44 12 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 44 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 44 14 U. U. NNP work_av4lzmkbbzda3hgvpstyfssllm 44 15 von von NNP work_av4lzmkbbzda3hgvpstyfssllm 44 16 Döbeln Döbeln NNP work_av4lzmkbbzda3hgvpstyfssllm 44 17 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 44 18 patient patient NNP work_av4lzmkbbzda3hgvpstyfssllm 44 19 013 013 CD work_av4lzmkbbzda3hgvpstyfssllm 44 20 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 44 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 44 22 R.D. R.D. NNP work_av4lzmkbbzda3hgvpstyfssllm 45 1 De De NNP work_av4lzmkbbzda3hgvpstyfssllm 45 2 Kre- Kre- NNP work_av4lzmkbbzda3hgvpstyfssllm 45 3 mer mer NNP work_av4lzmkbbzda3hgvpstyfssllm 45 4 Dodelson Dodelson NNP work_av4lzmkbbzda3hgvpstyfssllm 45 5 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 45 6 patient patient JJ work_av4lzmkbbzda3hgvpstyfssllm 45 7 014 014 CD work_av4lzmkbbzda3hgvpstyfssllm 45 8 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 45 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 45 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 45 11 D.H. D.H. NNP work_av4lzmkbbzda3hgvpstyfssllm 45 12 Morton Morton NNP work_av4lzmkbbzda3hgvpstyfssllm 45 13 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 45 14 patient patient JJ work_av4lzmkbbzda3hgvpstyfssllm 45 15 015 015 CD work_av4lzmkbbzda3hgvpstyfssllm 45 16 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 45 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 46 1 Skin skin NN work_av4lzmkbbzda3hgvpstyfssllm 46 2 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 46 3 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 46 4 cultured culture VBN work_av4lzmkbbzda3hgvpstyfssllm 46 5 in in IN work_av4lzmkbbzda3hgvpstyfssllm 46 6 Eagle Eagle NNP work_av4lzmkbbzda3hgvpstyfssllm 46 7 ’s ’s POS work_av4lzmkbbzda3hgvpstyfssllm 46 8 minimal minimal JJ work_av4lzmkbbzda3hgvpstyfssllm 46 9 essential essential JJ work_av4lzmkbbzda3hgvpstyfssllm 46 10 medium medium NN work_av4lzmkbbzda3hgvpstyfssllm 46 11 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 46 12 Life Life NNP work_av4lzmkbbzda3hgvpstyfssllm 46 13 Technologies Technologies NNPS work_av4lzmkbbzda3hgvpstyfssllm 46 14 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 46 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 46 16 Rockville Rockville NNP work_av4lzmkbbzda3hgvpstyfssllm 46 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 46 18 Maryland Maryland NNP work_av4lzmkbbzda3hgvpstyfssllm 46 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 46 20 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 46 21 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 46 22 supplemented supplement VBD work_av4lzmkbbzda3hgvpstyfssllm 46 23 with with IN work_av4lzmkbbzda3hgvpstyfssllm 46 24 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 46 25 mmol mmol NN work_av4lzmkbbzda3hgvpstyfssllm 46 26 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 46 27 l l NNP work_av4lzmkbbzda3hgvpstyfssllm 46 28 L L NNP work_av4lzmkbbzda3hgvpstyfssllm 46 29 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 46 30 gluta- gluta- NNP work_av4lzmkbbzda3hgvpstyfssllm 46 31 mine mine NN work_av4lzmkbbzda3hgvpstyfssllm 46 32 and and CC work_av4lzmkbbzda3hgvpstyfssllm 46 33 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 46 34 % % NN work_av4lzmkbbzda3hgvpstyfssllm 46 35 FCS FCS NNP work_av4lzmkbbzda3hgvpstyfssllm 46 36 . . . work_av4lzmkbbzda3hgvpstyfssllm 47 1 Complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 47 2 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 47 3 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 47 4 modified modify VBN work_av4lzmkbbzda3hgvpstyfssllm 47 5 from from IN work_av4lzmkbbzda3hgvpstyfssllm 47 6 that that DT work_av4lzmkbbzda3hgvpstyfssllm 47 7 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 47 8 by by IN work_av4lzmkbbzda3hgvpstyfssllm 47 9 Wolf Wolf NNP work_av4lzmkbbzda3hgvpstyfssllm 47 10 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 47 11 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 47 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 48 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 48 2 26 26 CD work_av4lzmkbbzda3hgvpstyfssllm 48 3 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 48 4 . . . work_av4lzmkbbzda3hgvpstyfssllm 49 1 Briefly briefly RB work_av4lzmkbbzda3hgvpstyfssllm 49 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 49 3 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 49 4 produced produce VBD work_av4lzmkbbzda3hgvpstyfssllm 49 5 heterokaryons heterokaryon NNS work_av4lzmkbbzda3hgvpstyfssllm 49 6 by by IN work_av4lzmkbbzda3hgvpstyfssllm 49 7 a a DT work_av4lzmkbbzda3hgvpstyfssllm 49 8 90- 90- NNP work_av4lzmkbbzda3hgvpstyfssllm 49 9 or or CC work_av4lzmkbbzda3hgvpstyfssllm 49 10 120-second 120-second CD work_av4lzmkbbzda3hgvpstyfssllm 49 11 treatment treatment NN work_av4lzmkbbzda3hgvpstyfssllm 49 12 with with IN work_av4lzmkbbzda3hgvpstyfssllm 49 13 40 40 CD work_av4lzmkbbzda3hgvpstyfssllm 49 14 % % NN work_av4lzmkbbzda3hgvpstyfssllm 49 15 PEG PEG NNP work_av4lzmkbbzda3hgvpstyfssllm 49 16 harvested harvest VBD work_av4lzmkbbzda3hgvpstyfssllm 49 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 49 18 cells cell NNS work_av4lzmkbbzda3hgvpstyfssllm 49 19 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 49 20 days day NNS work_av4lzmkbbzda3hgvpstyfssllm 49 21 later later RB work_av4lzmkbbzda3hgvpstyfssllm 49 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 49 23 measured measure VBN work_av4lzmkbbzda3hgvpstyfssllm 49 24 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 49 25 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 49 26 as as IN work_av4lzmkbbzda3hgvpstyfssllm 49 27 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 49 28 previously previously RB work_av4lzmkbbzda3hgvpstyfssllm 49 29 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 49 30 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 49 31 , , , work_av4lzmkbbzda3hgvpstyfssllm 49 32 27 27 CD work_av4lzmkbbzda3hgvpstyfssllm 49 33 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 49 34 . . . work_av4lzmkbbzda3hgvpstyfssllm 50 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 50 2 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 50 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 50 4 cultures culture NNS work_av4lzmkbbzda3hgvpstyfssllm 50 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 50 6 mixed mixed JJ work_av4lzmkbbzda3hgvpstyfssllm 50 7 but but CC work_av4lzmkbbzda3hgvpstyfssllm 50 8 unfused unfused JJ work_av4lzmkbbzda3hgvpstyfssllm 50 9 cells cell NNS work_av4lzmkbbzda3hgvpstyfssllm 50 10 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 50 11 subtracted subtract VBN work_av4lzmkbbzda3hgvpstyfssllm 50 12 as as IN work_av4lzmkbbzda3hgvpstyfssllm 50 13 blank blank JJ work_av4lzmkbbzda3hgvpstyfssllm 50 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 50 15 self self NN work_av4lzmkbbzda3hgvpstyfssllm 50 16 fusions fusion NNS work_av4lzmkbbzda3hgvpstyfssllm 50 17 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 50 18 included include VBN work_av4lzmkbbzda3hgvpstyfssllm 50 19 as as IN work_av4lzmkbbzda3hgvpstyfssllm 50 20 a a DT work_av4lzmkbbzda3hgvpstyfssllm 50 21 negative negative JJ work_av4lzmkbbzda3hgvpstyfssllm 50 22 control control NN work_av4lzmkbbzda3hgvpstyfssllm 50 23 . . . work_av4lzmkbbzda3hgvpstyfssllm 51 1 Expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 51 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 51 3 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 51 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 51 5 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 51 6 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 51 7 in in IN work_av4lzmkbbzda3hgvpstyfssllm 51 8 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 51 9 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 51 10 harvested harvest VBD work_av4lzmkbbzda3hgvpstyfssllm 51 11 cultured cultured JJ work_av4lzmkbbzda3hgvpstyfssllm 51 12 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 51 13 by by IN work_av4lzmkbbzda3hgvpstyfssllm 51 14 trypsinization trypsinization NN work_av4lzmkbbzda3hgvpstyfssllm 51 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 16 disrupted disrupt VBD work_av4lzmkbbzda3hgvpstyfssllm 51 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 51 18 washed wash VBN work_av4lzmkbbzda3hgvpstyfssllm 51 19 cells cell NNS work_av4lzmkbbzda3hgvpstyfssllm 51 20 by by IN work_av4lzmkbbzda3hgvpstyfssllm 51 21 homogenization homogenization NN work_av4lzmkbbzda3hgvpstyfssllm 51 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 23 har- har- NNP work_av4lzmkbbzda3hgvpstyfssllm 51 24 vested vest VBD work_av4lzmkbbzda3hgvpstyfssllm 51 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 51 26 mitochondria mitochondrion NNS work_av4lzmkbbzda3hgvpstyfssllm 51 27 by by IN work_av4lzmkbbzda3hgvpstyfssllm 51 28 differential differential NN work_av4lzmkbbzda3hgvpstyfssllm 51 29 centrifugation centrifugation NN work_av4lzmkbbzda3hgvpstyfssllm 51 30 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 51 31 28 28 CD work_av4lzmkbbzda3hgvpstyfssllm 51 32 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 51 33 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 34 suspended suspend VBD work_av4lzmkbbzda3hgvpstyfssllm 51 35 them -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 51 36 in in IN work_av4lzmkbbzda3hgvpstyfssllm 51 37 SDS SDS NNP work_av4lzmkbbzda3hgvpstyfssllm 51 38 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 51 39 buffer buffer NNP work_av4lzmkbbzda3hgvpstyfssllm 51 40 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 51 41 50 50 CD work_av4lzmkbbzda3hgvpstyfssllm 51 42 mM mM NNP work_av4lzmkbbzda3hgvpstyfssllm 51 43 Tris- Tris- VBN work_av4lzmkbbzda3hgvpstyfssllm 51 44 acetate acetate JJ work_av4lzmkbbzda3hgvpstyfssllm 51 45 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 46 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 51 47 % % NN work_av4lzmkbbzda3hgvpstyfssllm 51 48 SDS sds NN work_av4lzmkbbzda3hgvpstyfssllm 51 49 [ [ -LRB- work_av4lzmkbbzda3hgvpstyfssllm 51 50 wt wt NNP work_av4lzmkbbzda3hgvpstyfssllm 51 51 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 51 52 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 51 53 ] ] -RRB- work_av4lzmkbbzda3hgvpstyfssllm 51 54 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 55 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 51 56 mM mM NNP work_av4lzmkbbzda3hgvpstyfssllm 51 57 DTT DTT NNP work_av4lzmkbbzda3hgvpstyfssllm 51 58 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 59 0.02 0.02 CD work_av4lzmkbbzda3hgvpstyfssllm 51 60 % % NN work_av4lzmkbbzda3hgvpstyfssllm 51 61 [ [ -LRB- work_av4lzmkbbzda3hgvpstyfssllm 51 62 wt wt NNP work_av4lzmkbbzda3hgvpstyfssllm 51 63 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 51 64 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 51 65 ] ] -RRB- work_av4lzmkbbzda3hgvpstyfssllm 51 66 bromphenol bromphenol NN work_av4lzmkbbzda3hgvpstyfssllm 51 67 blue blue NNP work_av4lzmkbbzda3hgvpstyfssllm 51 68 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 51 69 , , , work_av4lzmkbbzda3hgvpstyfssllm 51 70 and and CC work_av4lzmkbbzda3hgvpstyfssllm 51 71 dissolved dissolve VBD work_av4lzmkbbzda3hgvpstyfssllm 51 72 the the DT work_av4lzmkbbzda3hgvpstyfssllm 51 73 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 51 74 by by IN work_av4lzmkbbzda3hgvpstyfssllm 51 75 boil- boil- NNP work_av4lzmkbbzda3hgvpstyfssllm 51 76 ing ing NNP work_av4lzmkbbzda3hgvpstyfssllm 51 77 for for IN work_av4lzmkbbzda3hgvpstyfssllm 51 78 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 51 79 minutes minute NNS work_av4lzmkbbzda3hgvpstyfssllm 51 80 . . . work_av4lzmkbbzda3hgvpstyfssllm 52 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 52 2 cellular cellular JJ work_av4lzmkbbzda3hgvpstyfssllm 52 3 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 52 4 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 52 5 separated separate VBN work_av4lzmkbbzda3hgvpstyfssllm 52 6 by by IN work_av4lzmkbbzda3hgvpstyfssllm 52 7 SDS SDS NNP work_av4lzmkbbzda3hgvpstyfssllm 52 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 52 9 PAGE PAGE NNP work_av4lzmkbbzda3hgvpstyfssllm 52 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 52 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 52 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 52 13 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 52 14 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 52 15 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 52 16 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 52 17 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 52 18 detected detect VBN work_av4lzmkbbzda3hgvpstyfssllm 52 19 with with IN work_av4lzmkbbzda3hgvpstyfssllm 52 20 an an DT work_av4lzmkbbzda3hgvpstyfssllm 52 21 avidin avidin NNP work_av4lzmkbbzda3hgvpstyfssllm 52 22 alkaline alkaline NNP work_av4lzmkbbzda3hgvpstyfssllm 52 23 phosphatase phosphatase NNP work_av4lzmkbbzda3hgvpstyfssllm 52 24 conjugate conjugate NNP work_av4lzmkbbzda3hgvpstyfssllm 52 25 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 52 26 avidin avidin NNP work_av4lzmkbbzda3hgvpstyfssllm 52 27 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 52 28 AP AP NNP work_av4lzmkbbzda3hgvpstyfssllm 52 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 52 30 1:8,000 1:8,000 CD work_av4lzmkbbzda3hgvpstyfssllm 52 31 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 52 32 Bio Bio NNP work_av4lzmkbbzda3hgvpstyfssllm 52 33 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 52 34 Rad Rad NNP work_av4lzmkbbzda3hgvpstyfssllm 52 35 Laboratories Laboratories NNP work_av4lzmkbbzda3hgvpstyfssllm 52 36 AG AG NNP work_av4lzmkbbzda3hgvpstyfssllm 52 37 , , , work_av4lzmkbbzda3hgvpstyfssllm 52 38 Glat- Glat- NNP work_av4lzmkbbzda3hgvpstyfssllm 52 39 tbrugg tbrugg VBD work_av4lzmkbbzda3hgvpstyfssllm 52 40 , , , work_av4lzmkbbzda3hgvpstyfssllm 52 41 Switzerland Switzerland NNP work_av4lzmkbbzda3hgvpstyfssllm 52 42 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 52 43 . . . work_av4lzmkbbzda3hgvpstyfssllm 53 1 Fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 53 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 53 3 an an DT work_av4lzmkbbzda3hgvpstyfssllm 53 4 unaffected unaffected JJ work_av4lzmkbbzda3hgvpstyfssllm 53 5 control control NN work_av4lzmkbbzda3hgvpstyfssllm 53 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 53 7 a a DT work_av4lzmkbbzda3hgvpstyfssllm 53 8 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 53 9 with with IN work_av4lzmkbbzda3hgvpstyfssllm 53 10 isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 53 11 PC pc NN work_av4lzmkbbzda3hgvpstyfssllm 53 12 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 53 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 53 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 53 15 a a DT work_av4lzmkbbzda3hgvpstyfssllm 53 16 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 53 17 with with IN work_av4lzmkbbzda3hgvpstyfssllm 53 18 isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 53 19 PCCα PCCα NNP work_av4lzmkbbzda3hgvpstyfssllm 53 20 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 53 21 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 53 22 used use VBN work_av4lzmkbbzda3hgvpstyfssllm 53 23 to to TO work_av4lzmkbbzda3hgvpstyfssllm 53 24 confirm confirm VB work_av4lzmkbbzda3hgvpstyfssllm 53 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 53 26 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 53 27 of of IN work_av4lzmkbbzda3hgvpstyfssllm 53 28 the the DT work_av4lzmkbbzda3hgvpstyfssllm 53 29 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 53 30 bands band NNS work_av4lzmkbbzda3hgvpstyfssllm 53 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 54 1 cDNA cDNA NNP work_av4lzmkbbzda3hgvpstyfssllm 54 2 cloning cloning NNP work_av4lzmkbbzda3hgvpstyfssllm 54 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 54 4 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 54 5 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 54 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 54 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 54 8 chromosome chromosome NN work_av4lzmkbbzda3hgvpstyfssllm 54 9 mapping mapping NN work_av4lzmkbbzda3hgvpstyfssllm 54 10 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 54 11 obtained obtain VBD work_av4lzmkbbzda3hgvpstyfssllm 54 12 two two CD work_av4lzmkbbzda3hgvpstyfssllm 54 13 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 54 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 54 15 AI317324 AI317324 NNP work_av4lzmkbbzda3hgvpstyfssllm 54 16 and and CC work_av4lzmkbbzda3hgvpstyfssllm 54 17 AI117072 AI117072 NNP work_av4lzmkbbzda3hgvpstyfssllm 54 18 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 54 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 54 20 two two CD work_av4lzmkbbzda3hgvpstyfssllm 54 21 human human NN work_av4lzmkbbzda3hgvpstyfssllm 54 22 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 54 23 AA134548 AA134548 NNP work_av4lzmkbbzda3hgvpstyfssllm 54 24 and and CC work_av4lzmkbbzda3hgvpstyfssllm 54 25 AA101775 AA101775 NFP work_av4lzmkbbzda3hgvpstyfssllm 54 26 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 54 27 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 54 28 EST EST NNP work_av4lzmkbbzda3hgvpstyfssllm 54 29 clones clone NNS work_av4lzmkbbzda3hgvpstyfssllm 54 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 54 31 and and CC work_av4lzmkbbzda3hgvpstyfssllm 54 32 one one CD work_av4lzmkbbzda3hgvpstyfssllm 54 33 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 54 34 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 54 35 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 54 36 AI564487 AI564487 NNP work_av4lzmkbbzda3hgvpstyfssllm 54 37 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 54 38 EST EST NNP work_av4lzmkbbzda3hgvpstyfssllm 54 39 clone clone VBD work_av4lzmkbbzda3hgvpstyfssllm 54 40 from from IN work_av4lzmkbbzda3hgvpstyfssllm 54 41 the the DT work_av4lzmkbbzda3hgvpstyfssllm 54 42 IMAGE image NN work_av4lzmkbbzda3hgvpstyfssllm 54 43 consortium consortium NN work_av4lzmkbbzda3hgvpstyfssllm 54 44 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 54 45 Genome Genome NNP work_av4lzmkbbzda3hgvpstyfssllm 54 46 Systems Systems NNPS work_av4lzmkbbzda3hgvpstyfssllm 54 47 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 54 48 , , , work_av4lzmkbbzda3hgvpstyfssllm 54 49 St. St. NNP work_av4lzmkbbzda3hgvpstyfssllm 54 50 Louis Louis NNP work_av4lzmkbbzda3hgvpstyfssllm 54 51 , , , work_av4lzmkbbzda3hgvpstyfssllm 54 52 Missouri Missouri NNP work_av4lzmkbbzda3hgvpstyfssllm 54 53 , , , work_av4lzmkbbzda3hgvpstyfssllm 54 54 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 54 55 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 54 56 and and CC work_av4lzmkbbzda3hgvpstyfssllm 54 57 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 54 58 both both DT work_av4lzmkbbzda3hgvpstyfssllm 54 59 strands strand NNS work_av4lzmkbbzda3hgvpstyfssllm 54 60 with with IN work_av4lzmkbbzda3hgvpstyfssllm 54 61 an an DT work_av4lzmkbbzda3hgvpstyfssllm 54 62 ABI ABI NNP work_av4lzmkbbzda3hgvpstyfssllm 54 63 377 377 CD work_av4lzmkbbzda3hgvpstyfssllm 54 64 automated automate VBN work_av4lzmkbbzda3hgvpstyfssllm 54 65 sequencer sequencer NN work_av4lzmkbbzda3hgvpstyfssllm 54 66 . . . work_av4lzmkbbzda3hgvpstyfssllm 55 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 55 2 design design VB work_av4lzmkbbzda3hgvpstyfssllm 55 3 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 55 4 corresponding correspond VBG work_av4lzmkbbzda3hgvpstyfssllm 55 5 to to IN work_av4lzmkbbzda3hgvpstyfssllm 55 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 55 7 5′ 5′ JJ work_av4lzmkbbzda3hgvpstyfssllm 55 8 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 55 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 55 10 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 55 11 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 55 12 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 55 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 55 14 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 55 15 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 55 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 55 17 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 55 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 55 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 55 20 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 55 21 EST EST NNP work_av4lzmkbbzda3hgvpstyfssllm 55 22 clone clone NN work_av4lzmkbbzda3hgvpstyfssllm 55 23 AA337013 aa337013 NN work_av4lzmkbbzda3hgvpstyfssllm 55 24 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 55 25 not not RB work_av4lzmkbbzda3hgvpstyfssllm 55 26 available available JJ work_av4lzmkbbzda3hgvpstyfssllm 55 27 commercially commercially RB work_av4lzmkbbzda3hgvpstyfssllm 55 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 55 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 56 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 56 2 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 56 3 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 56 4 DV4418 DV4418 NNP work_av4lzmkbbzda3hgvpstyfssllm 56 5 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 6 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 56 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 8 5′-GACGCAGCTGCCTCTG 5′-gacgcagctgcctctg CD work_av4lzmkbbzda3hgvpstyfssllm 56 9 TAC TAC NNP work_av4lzmkbbzda3hgvpstyfssllm 56 10 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 56 12 DV4417 DV4417 NFP work_av4lzmkbbzda3hgvpstyfssllm 56 13 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 14 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 56 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 16 5′-TGGCCGGGCTCCAGGGACATG 5′-tggccgggctccagggacatg LS work_av4lzmkbbzda3hgvpstyfssllm 56 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 19 complementary complementary JJ work_av4lzmkbbzda3hgvpstyfssllm 56 20 to to IN work_av4lzmkbbzda3hgvpstyfssllm 56 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 56 22 5′ 5′ JJ work_av4lzmkbbzda3hgvpstyfssllm 56 23 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 56 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 25 and and CC work_av4lzmkbbzda3hgvpstyfssllm 56 26 DV4446 DV4446 NNP work_av4lzmkbbzda3hgvpstyfssllm 56 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 28 antisense antisense NNP work_av4lzmkbbzda3hgvpstyfssllm 56 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 30 5′-AACTGCTCTTTATGAGACCCC 5′-aactgctctttatgagacccc CD work_av4lzmkbbzda3hgvpstyfssllm 56 31 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 32 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 33 complementary complementary JJ work_av4lzmkbbzda3hgvpstyfssllm 56 34 to to IN work_av4lzmkbbzda3hgvpstyfssllm 56 35 the the DT work_av4lzmkbbzda3hgvpstyfssllm 56 36 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 56 37 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 56 38 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 39 to to TO work_av4lzmkbbzda3hgvpstyfssllm 56 40 amplify amplify VB work_av4lzmkbbzda3hgvpstyfssllm 56 41 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 56 42 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 56 43 length length NN work_av4lzmkbbzda3hgvpstyfssllm 56 44 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 56 45 MCCA mcca NN work_av4lzmkbbzda3hgvpstyfssllm 56 46 from from IN work_av4lzmkbbzda3hgvpstyfssllm 56 47 a a DT work_av4lzmkbbzda3hgvpstyfssllm 56 48 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 56 49 retina retina NNP work_av4lzmkbbzda3hgvpstyfssllm 56 50 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 56 51 library library NNP work_av4lzmkbbzda3hgvpstyfssllm 56 52 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 53 29 29 CD work_av4lzmkbbzda3hgvpstyfssllm 56 54 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 55 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 56 56 and and CC work_av4lzmkbbzda3hgvpstyfssllm 56 57 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 56 58 DV4496 DV4496 . work_av4lzmkbbzda3hgvpstyfssllm 56 59 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 60 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 56 61 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 62 5′-AGGACCTGAGCTCAGCTTCC 5′-aggacctgagctcagcttcc CD work_av4lzmkbbzda3hgvpstyfssllm 56 63 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 64 and and CC work_av4lzmkbbzda3hgvpstyfssllm 56 65 DV4497 DV4497 NNP work_av4lzmkbbzda3hgvpstyfssllm 56 66 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 67 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 56 68 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 69 5′-TCGGTGCCCGCCGCCATG 5′-tcggtgcccgccgccatg CD work_av4lzmkbbzda3hgvpstyfssllm 56 70 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 71 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 72 complementary complementary JJ work_av4lzmkbbzda3hgvpstyfssllm 56 73 to to IN work_av4lzmkbbzda3hgvpstyfssllm 56 74 the the DT work_av4lzmkbbzda3hgvpstyfssllm 56 75 5′ 5′ JJ work_av4lzmkbbzda3hgvpstyfssllm 56 76 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 56 77 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 78 and and CC work_av4lzmkbbzda3hgvpstyfssllm 56 79 DV DV NNP work_av4lzmkbbzda3hgvpstyfssllm 56 80 4495 4495 CD work_av4lzmkbbzda3hgvpstyfssllm 56 81 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 82 antisense antisense NN work_av4lzmkbbzda3hgvpstyfssllm 56 83 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 84 5′-ACTG- 5′-actg- CD work_av4lzmkbbzda3hgvpstyfssllm 56 85 TAACAGCCTCATGTTCG TAACAGCCTCATGTTCG NNP work_av4lzmkbbzda3hgvpstyfssllm 56 86 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 87 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 88 complementary complementary JJ work_av4lzmkbbzda3hgvpstyfssllm 56 89 to to IN work_av4lzmkbbzda3hgvpstyfssllm 56 90 the the DT work_av4lzmkbbzda3hgvpstyfssllm 56 91 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 56 92 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 56 93 , , , work_av4lzmkbbzda3hgvpstyfssllm 56 94 to to TO work_av4lzmkbbzda3hgvpstyfssllm 56 95 amplify amplify VB work_av4lzmkbbzda3hgvpstyfssllm 56 96 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 56 97 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 56 98 length length NN work_av4lzmkbbzda3hgvpstyfssllm 56 99 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 56 100 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 56 101 from from IN work_av4lzmkbbzda3hgvpstyfssllm 56 102 the the DT work_av4lzmkbbzda3hgvpstyfssllm 56 103 same same JJ work_av4lzmkbbzda3hgvpstyfssllm 56 104 human human NNP work_av4lzmkbbzda3hgvpstyfssllm 56 105 retina retina NNP work_av4lzmkbbzda3hgvpstyfssllm 56 106 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 56 107 library library NNP work_av4lzmkbbzda3hgvpstyfssllm 56 108 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 56 109 29 29 CD work_av4lzmkbbzda3hgvpstyfssllm 56 110 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 56 111 . . . work_av4lzmkbbzda3hgvpstyfssllm 57 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 57 2 gel gel VBP work_av4lzmkbbzda3hgvpstyfssllm 57 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 57 4 purified purify VBD work_av4lzmkbbzda3hgvpstyfssllm 57 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 57 6 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 57 7 products product NNS work_av4lzmkbbzda3hgvpstyfssllm 57 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 57 9 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 57 10 them -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 57 11 directly directly RB work_av4lzmkbbzda3hgvpstyfssllm 57 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 58 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 58 2 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 58 3 alignments alignment NNS work_av4lzmkbbzda3hgvpstyfssllm 58 4 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 58 5 prepared prepare VBN work_av4lzmkbbzda3hgvpstyfssllm 58 6 with with IN work_av4lzmkbbzda3hgvpstyfssllm 58 7 MegAlign MegAlign NNP work_av4lzmkbbzda3hgvpstyfssllm 58 8 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 58 9 DNASTAR DNASTAR NNP work_av4lzmkbbzda3hgvpstyfssllm 58 10 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 58 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 58 12 Madison Madison NNP work_av4lzmkbbzda3hgvpstyfssllm 58 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 58 14 Wisconsin Wisconsin NNP work_av4lzmkbbzda3hgvpstyfssllm 58 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 58 16 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 58 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 58 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 59 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 59 2 mapped map VBD work_av4lzmkbbzda3hgvpstyfssllm 59 3 HsMCCA HsMCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 59 4 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 59 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 59 6 Genebridge Genebridge NNP work_av4lzmkbbzda3hgvpstyfssllm 59 7 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 59 8 radia- radia- NN work_av4lzmkbbzda3hgvpstyfssllm 59 9 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 59 10 hybrid hybrid JJ work_av4lzmkbbzda3hgvpstyfssllm 59 11 panel panel NN work_av4lzmkbbzda3hgvpstyfssllm 59 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 59 13 Research Research NNP work_av4lzmkbbzda3hgvpstyfssllm 59 14 Genetics Genetics NNP work_av4lzmkbbzda3hgvpstyfssllm 59 15 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 59 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 59 17 Huntsville Huntsville NNP work_av4lzmkbbzda3hgvpstyfssllm 59 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 59 19 Alabama Alabama NNP work_av4lzmkbbzda3hgvpstyfssllm 59 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 59 21 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 59 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 59 23 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 59 24 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 59 25 DV4621 DV4621 NNP work_av4lzmkbbzda3hgvpstyfssllm 59 26 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 59 27 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 59 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 59 29 5′- 5′- JJ work_av4lzmkbbzda3hgvpstyfssllm 59 30 TTTGTCGTCTCAGACTCGATG TTTGTCGTCTCAGACTCGATG NNP work_av4lzmkbbzda3hgvpstyfssllm 59 31 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 59 32 and and CC work_av4lzmkbbzda3hgvpstyfssllm 59 33 DV4740 DV4740 NNP work_av4lzmkbbzda3hgvpstyfssllm 59 34 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 59 35 antisense antisense NN work_av4lzmkbbzda3hgvpstyfssllm 59 36 , , , work_av4lzmkbbzda3hgvpstyfssllm 59 37 5′-AGTCAGAAAAATAAGGCCAACC 5′-agtcagaaaaataaggccaacc LS work_av4lzmkbbzda3hgvpstyfssllm 59 38 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 59 39 corresponding correspond VBG work_av4lzmkbbzda3hgvpstyfssllm 59 40 to to IN work_av4lzmkbbzda3hgvpstyfssllm 59 41 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 59 42 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 59 43 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 59 44 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 59 45 of of IN work_av4lzmkbbzda3hgvpstyfssllm 59 46 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 59 47 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 59 48 and and CC work_av4lzmkbbzda3hgvpstyfssllm 59 49 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 59 50 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 59 51 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 59 52 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 59 53 of of IN work_av4lzmkbbzda3hgvpstyfssllm 59 54 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 59 55 7 7 CD work_av4lzmkbbzda3hgvpstyfssllm 59 56 . . . work_av4lzmkbbzda3hgvpstyfssllm 60 1 Isolation isolation NN work_av4lzmkbbzda3hgvpstyfssllm 60 2 and and CC work_av4lzmkbbzda3hgvpstyfssllm 60 3 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 60 4 spectrometry spectrometry NN work_av4lzmkbbzda3hgvpstyfssllm 60 5 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 60 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 60 7 biotin- biotin- NNP work_av4lzmkbbzda3hgvpstyfssllm 60 8 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 60 9 proteins protein VBZ work_av4lzmkbbzda3hgvpstyfssllm 60 10 Enrichment Enrichment NNP work_av4lzmkbbzda3hgvpstyfssllm 60 11 for for IN work_av4lzmkbbzda3hgvpstyfssllm 60 12 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 60 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 60 14 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 60 15 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 60 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 61 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 61 2 homogenized homogenize VBD work_av4lzmkbbzda3hgvpstyfssllm 61 3 0.32 0.32 CD work_av4lzmkbbzda3hgvpstyfssllm 61 4 g g NN work_av4lzmkbbzda3hgvpstyfssllm 61 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 61 6 flash flash NNP work_av4lzmkbbzda3hgvpstyfssllm 61 7 frozen frozen NNP work_av4lzmkbbzda3hgvpstyfssllm 61 8 male male JJ work_av4lzmkbbzda3hgvpstyfssllm 61 9 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 61 10 kidney kidney NN work_av4lzmkbbzda3hgvpstyfssllm 61 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 61 12 1.5 1.5 CD work_av4lzmkbbzda3hgvpstyfssllm 61 13 ml ml NN work_av4lzmkbbzda3hgvpstyfssllm 61 14 buffer buffer NN work_av4lzmkbbzda3hgvpstyfssllm 61 15 A a DT work_av4lzmkbbzda3hgvpstyfssllm 61 16 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 61 17 100 100 CD work_av4lzmkbbzda3hgvpstyfssllm 61 18 mM mM NNP work_av4lzmkbbzda3hgvpstyfssllm 61 19 Tris Tris NNP work_av4lzmkbbzda3hgvpstyfssllm 61 20 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 61 21 HCl HCl NNP work_av4lzmkbbzda3hgvpstyfssllm 61 22 [ [ -LRB- work_av4lzmkbbzda3hgvpstyfssllm 61 23 pH pH NNP work_av4lzmkbbzda3hgvpstyfssllm 61 24 7.4 7.4 CD work_av4lzmkbbzda3hgvpstyfssllm 61 25 ] ] -RRB- work_av4lzmkbbzda3hgvpstyfssllm 61 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 61 27 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 61 28 mM mm NN work_av4lzmkbbzda3hgvpstyfssllm 61 29 DTT DTT NNP work_av4lzmkbbzda3hgvpstyfssllm 61 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 61 31 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 61 32 mM mM NNP work_av4lzmkbbzda3hgvpstyfssllm 61 33 EDTA EDTA NNP work_av4lzmkbbzda3hgvpstyfssllm 61 34 , , , work_av4lzmkbbzda3hgvpstyfssllm 61 35 0.1 0.1 CD work_av4lzmkbbzda3hgvpstyfssllm 61 36 % % NN work_av4lzmkbbzda3hgvpstyfssllm 61 37 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 61 38 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 61 39 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 61 40 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 61 41 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 61 42 Triton Triton NNP work_av4lzmkbbzda3hgvpstyfssllm 61 43 X-100 X-100 NNP work_av4lzmkbbzda3hgvpstyfssllm 61 44 , , , work_av4lzmkbbzda3hgvpstyfssllm 61 45 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 61 46 % % NN work_av4lzmkbbzda3hgvpstyfssllm 61 47 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 61 48 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 61 49 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 61 50 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 61 51 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 61 52 glycerol glycerol NN work_av4lzmkbbzda3hgvpstyfssllm 61 53 , , , work_av4lzmkbbzda3hgvpstyfssllm 61 54 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 61 55 µM µM NNP work_av4lzmkbbzda3hgvpstyfssllm 61 56 DMSF DMSF NNP work_av4lzmkbbzda3hgvpstyfssllm 61 57 , , , work_av4lzmkbbzda3hgvpstyfssllm 61 58 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 61 59 tablet tablet NN work_av4lzmkbbzda3hgvpstyfssllm 61 60 cocktail cocktail NN work_av4lzmkbbzda3hgvpstyfssllm 61 61 protease protease NN work_av4lzmkbbzda3hgvpstyfssllm 61 62 inhibitor inhibitor NN work_av4lzmkbbzda3hgvpstyfssllm 61 63 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 61 64 Boehringer Boehringer NNP work_av4lzmkbbzda3hgvpstyfssllm 61 65 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 61 66 Mannheim Mannheim NNP work_av4lzmkbbzda3hgvpstyfssllm 61 67 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 61 68 and and CC work_av4lzmkbbzda3hgvpstyfssllm 61 69 centrifuged centrifuge VBD work_av4lzmkbbzda3hgvpstyfssllm 61 70 the the DT work_av4lzmkbbzda3hgvpstyfssllm 61 71 homogenate homogenate NN work_av4lzmkbbzda3hgvpstyfssllm 61 72 at at IN work_av4lzmkbbzda3hgvpstyfssllm 61 73 20,000 20,000 CD work_av4lzmkbbzda3hgvpstyfssllm 61 74 g g NN work_av4lzmkbbzda3hgvpstyfssllm 61 75 for for IN work_av4lzmkbbzda3hgvpstyfssllm 61 76 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 61 77 minutes minute NNS work_av4lzmkbbzda3hgvpstyfssllm 61 78 at at IN work_av4lzmkbbzda3hgvpstyfssllm 61 79 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 61 80 ° ° NNS work_av4lzmkbbzda3hgvpstyfssllm 61 81 C C NNP work_av4lzmkbbzda3hgvpstyfssllm 61 82 . . . work_av4lzmkbbzda3hgvpstyfssllm 62 1 PEG PEG NNP work_av4lzmkbbzda3hgvpstyfssllm 62 2 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 62 3 added add VBN work_av4lzmkbbzda3hgvpstyfssllm 62 4 to to IN work_av4lzmkbbzda3hgvpstyfssllm 62 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 62 6 supernatant supernatant JJ work_av4lzmkbbzda3hgvpstyfssllm 62 7 to to IN work_av4lzmkbbzda3hgvpstyfssllm 62 8 a a DT work_av4lzmkbbzda3hgvpstyfssllm 62 9 final final JJ work_av4lzmkbbzda3hgvpstyfssllm 62 10 concentration concentration NN work_av4lzmkbbzda3hgvpstyfssllm 62 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 62 12 16 16 CD work_av4lzmkbbzda3hgvpstyfssllm 62 13 % % NN work_av4lzmkbbzda3hgvpstyfssllm 62 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 62 15 wt wt NNP work_av4lzmkbbzda3hgvpstyfssllm 62 16 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 62 17 vol vol NNP work_av4lzmkbbzda3hgvpstyfssllm 62 18 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 62 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 62 20 and and CC work_av4lzmkbbzda3hgvpstyfssllm 62 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 62 22 mixture mixture NN work_av4lzmkbbzda3hgvpstyfssllm 62 23 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 62 24 centrifuged centrifuge VBN work_av4lzmkbbzda3hgvpstyfssllm 62 25 at at IN work_av4lzmkbbzda3hgvpstyfssllm 62 26 20,000 20,000 CD work_av4lzmkbbzda3hgvpstyfssllm 62 27 g g NN work_av4lzmkbbzda3hgvpstyfssllm 62 28 for for IN work_av4lzmkbbzda3hgvpstyfssllm 62 29 30 30 CD work_av4lzmkbbzda3hgvpstyfssllm 62 30 minutes minute NNS work_av4lzmkbbzda3hgvpstyfssllm 62 31 at at IN work_av4lzmkbbzda3hgvpstyfssllm 62 32 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 62 33 ° ° NNS work_av4lzmkbbzda3hgvpstyfssllm 62 34 C C NNP work_av4lzmkbbzda3hgvpstyfssllm 62 35 . . . work_av4lzmkbbzda3hgvpstyfssllm 63 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 63 2 pellet pellet NN work_av4lzmkbbzda3hgvpstyfssllm 63 3 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 63 4 resus- resus- NN work_av4lzmkbbzda3hgvpstyfssllm 63 5 pended pende VBN work_av4lzmkbbzda3hgvpstyfssllm 63 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 63 7 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 63 8 ml ml NN work_av4lzmkbbzda3hgvpstyfssllm 63 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 63 10 buffer buffer NN work_av4lzmkbbzda3hgvpstyfssllm 63 11 A A NNP work_av4lzmkbbzda3hgvpstyfssllm 63 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 63 13 approximately approximately RB work_av4lzmkbbzda3hgvpstyfssllm 63 14 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 63 15 × × CD work_av4lzmkbbzda3hgvpstyfssllm 63 16 108 108 CD work_av4lzmkbbzda3hgvpstyfssllm 63 17 pre- pre- RB work_av4lzmkbbzda3hgvpstyfssllm 63 18 washed wash VBD work_av4lzmkbbzda3hgvpstyfssllm 63 19 M280 M280 NNP work_av4lzmkbbzda3hgvpstyfssllm 63 20 streptavidin streptavidin NNS work_av4lzmkbbzda3hgvpstyfssllm 63 21 Dynabeads Dynabeads NNP work_av4lzmkbbzda3hgvpstyfssllm 63 22 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 63 23 Dynal Dynal NNP work_av4lzmkbbzda3hgvpstyfssllm 63 24 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 63 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 63 26 Lake Lake NNP work_av4lzmkbbzda3hgvpstyfssllm 63 27 Success Success NNP work_av4lzmkbbzda3hgvpstyfssllm 63 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 63 29 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 63 30 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 63 31 , , , work_av4lzmkbbzda3hgvpstyfssllm 63 32 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 63 33 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 63 34 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 63 35 added add VBN work_av4lzmkbbzda3hgvpstyfssllm 63 36 , , , work_av4lzmkbbzda3hgvpstyfssllm 63 37 and and CC work_av4lzmkbbzda3hgvpstyfssllm 63 38 the the DT work_av4lzmkbbzda3hgvpstyfssllm 63 39 slur- slur- NN work_av4lzmkbbzda3hgvpstyfssllm 63 40 ry ry IN work_av4lzmkbbzda3hgvpstyfssllm 63 41 mixed mix VBN work_av4lzmkbbzda3hgvpstyfssllm 63 42 by by IN work_av4lzmkbbzda3hgvpstyfssllm 63 43 rotating rotate VBG work_av4lzmkbbzda3hgvpstyfssllm 63 44 for for IN work_av4lzmkbbzda3hgvpstyfssllm 63 45 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 63 46 hour hour NN work_av4lzmkbbzda3hgvpstyfssllm 63 47 at at IN work_av4lzmkbbzda3hgvpstyfssllm 63 48 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 63 49 ° ° NNS work_av4lzmkbbzda3hgvpstyfssllm 63 50 C C NNP work_av4lzmkbbzda3hgvpstyfssllm 63 51 . . . work_av4lzmkbbzda3hgvpstyfssllm 64 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 64 2 washed wash VBD work_av4lzmkbbzda3hgvpstyfssllm 64 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 64 4 beads beads NN work_av4lzmkbbzda3hgvpstyfssllm 64 5 five five CD work_av4lzmkbbzda3hgvpstyfssllm 64 6 times time NNS work_av4lzmkbbzda3hgvpstyfssllm 64 7 with with IN work_av4lzmkbbzda3hgvpstyfssllm 64 8 buffer buffer NN work_av4lzmkbbzda3hgvpstyfssllm 64 9 B B NNP work_av4lzmkbbzda3hgvpstyfssllm 64 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 64 11 0.25 0.25 CD work_av4lzmkbbzda3hgvpstyfssllm 64 12 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 64 13 KCl KCl NNS work_av4lzmkbbzda3hgvpstyfssllm 64 14 in in IN work_av4lzmkbbzda3hgvpstyfssllm 64 15 buffer buffer NNP work_av4lzmkbbzda3hgvpstyfssllm 64 16 A A NNP work_av4lzmkbbzda3hgvpstyfssllm 64 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 64 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 64 19 resuspended resuspend VBD work_av4lzmkbbzda3hgvpstyfssllm 64 20 them -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 64 21 in in IN work_av4lzmkbbzda3hgvpstyfssllm 64 22 200 200 CD work_av4lzmkbbzda3hgvpstyfssllm 64 23 µl µl IN work_av4lzmkbbzda3hgvpstyfssllm 64 24 of of IN work_av4lzmkbbzda3hgvpstyfssllm 64 25 XI XI NNP work_av4lzmkbbzda3hgvpstyfssllm 64 26 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 64 27 loading loading NN work_av4lzmkbbzda3hgvpstyfssllm 64 28 buffer buffer NNP work_av4lzmkbbzda3hgvpstyfssllm 64 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 64 30 boiled boil VBD work_av4lzmkbbzda3hgvpstyfssllm 64 31 for for IN work_av4lzmkbbzda3hgvpstyfssllm 64 32 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 64 33 minutes minute NNS work_av4lzmkbbzda3hgvpstyfssllm 64 34 , , , work_av4lzmkbbzda3hgvpstyfssllm 64 35 and and CC work_av4lzmkbbzda3hgvpstyfssllm 64 36 placed place VBD work_av4lzmkbbzda3hgvpstyfssllm 64 37 the the DT work_av4lzmkbbzda3hgvpstyfssllm 64 38 solution solution NN work_av4lzmkbbzda3hgvpstyfssllm 64 39 on on IN work_av4lzmkbbzda3hgvpstyfssllm 64 40 ice ice NN work_av4lzmkbbzda3hgvpstyfssllm 64 41 . . . work_av4lzmkbbzda3hgvpstyfssllm 65 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 65 2 loaded load VBD work_av4lzmkbbzda3hgvpstyfssllm 65 3 25 25 CD work_av4lzmkbbzda3hgvpstyfssllm 65 4 µl µl IN work_av4lzmkbbzda3hgvpstyfssllm 65 5 in in IN work_av4lzmkbbzda3hgvpstyfssllm 65 6 each each DT work_av4lzmkbbzda3hgvpstyfssllm 65 7 lane lane NN work_av4lzmkbbzda3hgvpstyfssllm 65 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 65 9 a a DT work_av4lzmkbbzda3hgvpstyfssllm 65 10 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 65 11 % % NN work_av4lzmkbbzda3hgvpstyfssllm 65 12 polyacry- polyacry- NN work_av4lzmkbbzda3hgvpstyfssllm 65 13 lamide lamide NNP work_av4lzmkbbzda3hgvpstyfssllm 65 14 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 65 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 65 16 stained stain VBD work_av4lzmkbbzda3hgvpstyfssllm 65 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 65 18 separated separated JJ work_av4lzmkbbzda3hgvpstyfssllm 65 19 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 65 20 with with IN work_av4lzmkbbzda3hgvpstyfssllm 65 21 Coomassie Coomassie NNP work_av4lzmkbbzda3hgvpstyfssllm 65 22 Brilliant Brilliant NNP work_av4lzmkbbzda3hgvpstyfssllm 65 23 blue blue NNP work_av4lzmkbbzda3hgvpstyfssllm 65 24 R250 r250 NN work_av4lzmkbbzda3hgvpstyfssllm 65 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 66 1 S S NNP work_av4lzmkbbzda3hgvpstyfssllm 66 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 66 3 carboxymethylation carboxymethylation NN work_av4lzmkbbzda3hgvpstyfssllm 66 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 66 5 proteolytic proteolytic JJ work_av4lzmkbbzda3hgvpstyfssllm 66 6 digestion digestion NN work_av4lzmkbbzda3hgvpstyfssllm 66 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 67 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 67 2 per- per- RB work_av4lzmkbbzda3hgvpstyfssllm 67 3 formed form VBD work_av4lzmkbbzda3hgvpstyfssllm 67 4 in in IN work_av4lzmkbbzda3hgvpstyfssllm 67 5 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 67 6 digestion digestion NN work_av4lzmkbbzda3hgvpstyfssllm 67 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 67 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 67 9 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 67 10 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 67 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 67 12 Coomassie Coomassie NNP work_av4lzmkbbzda3hgvpstyfssllm 67 13 blue blue NN work_av4lzmkbbzda3hgvpstyfssllm 67 14 – – : work_av4lzmkbbzda3hgvpstyfssllm 67 15 stained stain VBN work_av4lzmkbbzda3hgvpstyfssllm 67 16 SDS sds NN work_av4lzmkbbzda3hgvpstyfssllm 67 17 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 67 18 polyacrylamide polyacrylamide NN work_av4lzmkbbzda3hgvpstyfssllm 67 19 gels gel NNS work_av4lzmkbbzda3hgvpstyfssllm 67 20 according accord VBG work_av4lzmkbbzda3hgvpstyfssllm 67 21 to to IN work_av4lzmkbbzda3hgvpstyfssllm 67 22 Williams Williams NNP work_av4lzmkbbzda3hgvpstyfssllm 67 23 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 67 24 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 67 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 68 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 68 2 30 30 CD work_av4lzmkbbzda3hgvpstyfssllm 68 3 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 68 4 with with IN work_av4lzmkbbzda3hgvpstyfssllm 68 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 68 6 following follow VBG work_av4lzmkbbzda3hgvpstyfssllm 68 7 modifications modification NNS work_av4lzmkbbzda3hgvpstyfssllm 68 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 69 1 Cystines cystine NNS work_av4lzmkbbzda3hgvpstyfssllm 69 2 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 69 3 modified modify VBN work_av4lzmkbbzda3hgvpstyfssllm 69 4 by by IN work_av4lzmkbbzda3hgvpstyfssllm 69 5 car- car- NNP work_av4lzmkbbzda3hgvpstyfssllm 69 6 boxymethylation boxymethylation NN work_av4lzmkbbzda3hgvpstyfssllm 69 7 as as IN work_av4lzmkbbzda3hgvpstyfssllm 69 8 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 69 9 elsewhere elsewhere RB work_av4lzmkbbzda3hgvpstyfssllm 69 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 69 11 31 31 CD work_av4lzmkbbzda3hgvpstyfssllm 69 12 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 69 13 . . . work_av4lzmkbbzda3hgvpstyfssllm 70 1 After after IN work_av4lzmkbbzda3hgvpstyfssllm 70 2 rehydrating rehydrate VBG work_av4lzmkbbzda3hgvpstyfssllm 70 3 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 70 4 pieces piece NNS work_av4lzmkbbzda3hgvpstyfssllm 70 5 with with IN work_av4lzmkbbzda3hgvpstyfssllm 70 6 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 70 7 ng/µl ng/µl CD work_av4lzmkbbzda3hgvpstyfssllm 70 8 TPCK tpck NN work_av4lzmkbbzda3hgvpstyfssllm 70 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 70 10 treated treat VBN work_av4lzmkbbzda3hgvpstyfssllm 70 11 trypsin trypsin NN work_av4lzmkbbzda3hgvpstyfssllm 70 12 in in IN work_av4lzmkbbzda3hgvpstyfssllm 70 13 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 70 14 % % NN work_av4lzmkbbzda3hgvpstyfssllm 70 15 acetic acetic JJ work_av4lzmkbbzda3hgvpstyfssllm 70 16 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 70 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 70 18 excess excess JJ work_av4lzmkbbzda3hgvpstyfssllm 70 19 trypsin trypsin NN work_av4lzmkbbzda3hgvpstyfssllm 70 20 solution solution NN work_av4lzmkbbzda3hgvpstyfssllm 70 21 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 70 22 removed remove VBN work_av4lzmkbbzda3hgvpstyfssllm 70 23 and and CC work_av4lzmkbbzda3hgvpstyfssllm 70 24 the the DT work_av4lzmkbbzda3hgvpstyfssllm 70 25 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 70 26 piece piece NN work_av4lzmkbbzda3hgvpstyfssllm 70 27 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 70 28 covered cover VBN work_av4lzmkbbzda3hgvpstyfssllm 70 29 with with IN work_av4lzmkbbzda3hgvpstyfssllm 70 30 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 70 31 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 70 32 vol- vol- JJ work_av4lzmkbbzda3hgvpstyfssllm 70 33 umes ume NNS work_av4lzmkbbzda3hgvpstyfssllm 70 34 of of IN work_av4lzmkbbzda3hgvpstyfssllm 70 35 200 200 CD work_av4lzmkbbzda3hgvpstyfssllm 70 36 mM mM NNP work_av4lzmkbbzda3hgvpstyfssllm 70 37 NH4HCO3 NH4HCO3 . work_av4lzmkbbzda3hgvpstyfssllm 70 38 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 70 39 pH pH NNP work_av4lzmkbbzda3hgvpstyfssllm 70 40 8) 8) CD work_av4lzmkbbzda3hgvpstyfssllm 70 41 , , , work_av4lzmkbbzda3hgvpstyfssllm 70 42 at at IN work_av4lzmkbbzda3hgvpstyfssllm 70 43 37 37 CD work_av4lzmkbbzda3hgvpstyfssllm 70 44 ° ° , work_av4lzmkbbzda3hgvpstyfssllm 70 45 C C NNP work_av4lzmkbbzda3hgvpstyfssllm 70 46 for for IN work_av4lzmkbbzda3hgvpstyfssllm 70 47 48 48 CD work_av4lzmkbbzda3hgvpstyfssllm 70 48 hours hour NNS work_av4lzmkbbzda3hgvpstyfssllm 70 49 . . . work_av4lzmkbbzda3hgvpstyfssllm 71 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 71 2 resulting result VBG work_av4lzmkbbzda3hgvpstyfssllm 71 3 tryptic tryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 71 4 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 71 5 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 71 6 extracted extract VBN work_av4lzmkbbzda3hgvpstyfssllm 71 7 from from IN work_av4lzmkbbzda3hgvpstyfssllm 71 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 71 9 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 71 10 piece piece NN work_av4lzmkbbzda3hgvpstyfssllm 71 11 with with IN work_av4lzmkbbzda3hgvpstyfssllm 71 12 60 60 CD work_av4lzmkbbzda3hgvpstyfssllm 71 13 % % NN work_av4lzmkbbzda3hgvpstyfssllm 71 14 acetonitrile acetonitrile NN work_av4lzmkbbzda3hgvpstyfssllm 71 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 71 16 0.1 0.1 CD work_av4lzmkbbzda3hgvpstyfssllm 71 17 % % NN work_av4lzmkbbzda3hgvpstyfssllm 71 18 TFA tfa NN work_av4lzmkbbzda3hgvpstyfssllm 71 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 71 20 concentrated concentrate VBN work_av4lzmkbbzda3hgvpstyfssllm 71 21 by by IN work_av4lzmkbbzda3hgvpstyfssllm 71 22 drying dry VBG work_av4lzmkbbzda3hgvpstyfssllm 71 23 . . . work_av4lzmkbbzda3hgvpstyfssllm 72 1 Mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 72 2 spectrometry spectrometry NN work_av4lzmkbbzda3hgvpstyfssllm 72 3 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 72 4 . . . work_av4lzmkbbzda3hgvpstyfssllm 73 1 Tryptic tryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 73 2 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 73 3 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 73 4 resus- resus- NN work_av4lzmkbbzda3hgvpstyfssllm 73 5 pended pende VBN work_av4lzmkbbzda3hgvpstyfssllm 73 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 73 7 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 73 8 % % NN work_av4lzmkbbzda3hgvpstyfssllm 73 9 acetic acetic JJ work_av4lzmkbbzda3hgvpstyfssllm 73 10 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 73 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 73 12 loaded load VBD work_av4lzmkbbzda3hgvpstyfssllm 73 13 into into IN work_av4lzmkbbzda3hgvpstyfssllm 73 14 a a DT work_av4lzmkbbzda3hgvpstyfssllm 73 15 fused fuse VBN work_av4lzmkbbzda3hgvpstyfssllm 73 16 silica silica NN work_av4lzmkbbzda3hgvpstyfssllm 73 17 capillary capillary JJ work_av4lzmkbbzda3hgvpstyfssllm 73 18 column column NN work_av4lzmkbbzda3hgvpstyfssllm 73 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 73 20 75 75 CD work_av4lzmkbbzda3hgvpstyfssllm 73 21 µm µm NNP work_av4lzmkbbzda3hgvpstyfssllm 73 22 inner inner JJ work_av4lzmkbbzda3hgvpstyfssllm 73 23 diameter diameter NN work_av4lzmkbbzda3hgvpstyfssllm 73 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 73 25 packed pack VBD work_av4lzmkbbzda3hgvpstyfssllm 73 26 with with IN work_av4lzmkbbzda3hgvpstyfssllm 73 27 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 73 28 cm cm NNS work_av4lzmkbbzda3hgvpstyfssllm 73 29 of of IN work_av4lzmkbbzda3hgvpstyfssllm 73 30 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 73 31 µm µm NNP work_av4lzmkbbzda3hgvpstyfssllm 73 32 C18 C18 NNP work_av4lzmkbbzda3hgvpstyfssllm 73 33 reverse reverse JJ work_av4lzmkbbzda3hgvpstyfssllm 73 34 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 73 35 phase phase NN work_av4lzmkbbzda3hgvpstyfssllm 73 36 resin resin NN work_av4lzmkbbzda3hgvpstyfssllm 73 37 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 73 38 YMC YMC NNP work_av4lzmkbbzda3hgvpstyfssllm 73 39 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 73 40 , , , work_av4lzmkbbzda3hgvpstyfssllm 73 41 Atlanta Atlanta NNP work_av4lzmkbbzda3hgvpstyfssllm 73 42 , , , work_av4lzmkbbzda3hgvpstyfssllm 73 43 Georgia Georgia NNP work_av4lzmkbbzda3hgvpstyfssllm 73 44 , , , work_av4lzmkbbzda3hgvpstyfssllm 73 45 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 73 46 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 73 47 as as IN work_av4lzmkbbzda3hgvpstyfssllm 73 48 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 73 49 elsewhere elsewhere RB work_av4lzmkbbzda3hgvpstyfssllm 73 50 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 73 51 32 32 CD work_av4lzmkbbzda3hgvpstyfssllm 73 52 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 73 53 . . . work_av4lzmkbbzda3hgvpstyfssllm 74 1 A a DT work_av4lzmkbbzda3hgvpstyfssllm 74 2 30-minute 30-minute CD work_av4lzmkbbzda3hgvpstyfssllm 74 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 74 4 1.5–70 1.5–70 CD work_av4lzmkbbzda3hgvpstyfssllm 74 5 % % NN work_av4lzmkbbzda3hgvpstyfssllm 74 6 methanol methanol NN work_av4lzmkbbzda3hgvpstyfssllm 74 7 gradient gradient NN work_av4lzmkbbzda3hgvpstyfssllm 74 8 in in IN work_av4lzmkbbzda3hgvpstyfssllm 74 9 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 74 10 % % NN work_av4lzmkbbzda3hgvpstyfssllm 74 11 acetic acetic JJ work_av4lzmkbbzda3hgvpstyfssllm 74 12 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 74 13 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 74 14 applied apply VBN work_av4lzmkbbzda3hgvpstyfssllm 74 15 to to IN work_av4lzmkbbzda3hgvpstyfssllm 74 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 74 17 column column NN work_av4lzmkbbzda3hgvpstyfssllm 74 18 at at IN work_av4lzmkbbzda3hgvpstyfssllm 74 19 f f NNP work_av4lzmkbbzda3hgvpstyfssllm 74 20 low low JJ work_av4lzmkbbzda3hgvpstyfssllm 74 21 rates rate NNS work_av4lzmkbbzda3hgvpstyfssllm 74 22 of of IN work_av4lzmkbbzda3hgvpstyfssllm 74 23 250–300 250–300 CD work_av4lzmkbbzda3hgvpstyfssllm 74 24 nl nl NNP work_av4lzmkbbzda3hgvpstyfssllm 74 25 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 74 26 min min NNP work_av4lzmkbbzda3hgvpstyfssllm 74 27 . . . work_av4lzmkbbzda3hgvpstyfssllm 75 1 Eluting elute VBG work_av4lzmkbbzda3hgvpstyfssllm 75 2 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 75 3 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 75 4 electrosprayed electrospraye VBN work_av4lzmkbbzda3hgvpstyfssllm 75 5 directly directly RB work_av4lzmkbbzda3hgvpstyfssllm 75 6 into into IN work_av4lzmkbbzda3hgvpstyfssllm 75 7 a a DT work_av4lzmkbbzda3hgvpstyfssllm 75 8 Finnigan Finnigan NNP work_av4lzmkbbzda3hgvpstyfssllm 75 9 LCQ lcq NN work_av4lzmkbbzda3hgvpstyfssllm 75 10 atmospheric atmospheric JJ work_av4lzmkbbzda3hgvpstyfssllm 75 11 pressure pressure NN work_av4lzmkbbzda3hgvpstyfssllm 75 12 ionization ionization NN work_av4lzmkbbzda3hgvpstyfssllm 75 13 quadrupole quadrupole NNP work_av4lzmkbbzda3hgvpstyfssllm 75 14 ion ion NNP work_av4lzmkbbzda3hgvpstyfssllm 75 15 trap trap NN work_av4lzmkbbzda3hgvpstyfssllm 75 16 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 75 17 spectrometer spectrometer NN work_av4lzmkbbzda3hgvpstyfssllm 75 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 75 19 ThermoQuest ThermoQuest NNP work_av4lzmkbbzda3hgvpstyfssllm 75 20 Corp. Corp. NNP work_av4lzmkbbzda3hgvpstyfssllm 75 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 75 22 San San NNP work_av4lzmkbbzda3hgvpstyfssllm 75 23 Jose Jose NNP work_av4lzmkbbzda3hgvpstyfssllm 75 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 75 25 California California NNP work_av4lzmkbbzda3hgvpstyfssllm 75 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 75 27 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 75 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 75 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 76 1 Pos- Pos- NNP work_av4lzmkbbzda3hgvpstyfssllm 76 2 itive itive JJ work_av4lzmkbbzda3hgvpstyfssllm 76 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 76 4 ion ion NN work_av4lzmkbbzda3hgvpstyfssllm 76 5 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 76 6 spectra spectra NNP work_av4lzmkbbzda3hgvpstyfssllm 76 7 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 76 8 obtained obtain VBN work_av4lzmkbbzda3hgvpstyfssllm 76 9 at at IN work_av4lzmkbbzda3hgvpstyfssllm 76 10 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 76 11 XCal- XCal- NNP work_av4lzmkbbzda3hgvpstyfssllm 76 12 ibur ibur NN work_av4lzmkbbzda3hgvpstyfssllm 76 13 software software NN work_av4lzmkbbzda3hgvpstyfssllm 76 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 76 15 ThermoQuest ThermoQuest NNP work_av4lzmkbbzda3hgvpstyfssllm 76 16 Corp. Corp. NNP work_av4lzmkbbzda3hgvpstyfssllm 76 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 76 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 77 1 Peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 77 2 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 77 3 fragmented fragment VBN work_av4lzmkbbzda3hgvpstyfssllm 77 4 by by IN work_av4lzmkbbzda3hgvpstyfssllm 77 5 a a DT work_av4lzmkbbzda3hgvpstyfssllm 77 6 35 35 CD work_av4lzmkbbzda3hgvpstyfssllm 77 7 % % NN work_av4lzmkbbzda3hgvpstyfssllm 77 8 collision collision NN work_av4lzmkbbzda3hgvpstyfssllm 77 9 energy energy NN work_av4lzmkbbzda3hgvpstyfssllm 77 10 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 77 11 a a DT work_av4lzmkbbzda3hgvpstyfssllm 77 12 two- two- NN work_av4lzmkbbzda3hgvpstyfssllm 77 13 atomic atomic NNP work_av4lzmkbbzda3hgvpstyfssllm 77 14 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 77 15 mass mass JJ work_av4lzmkbbzda3hgvpstyfssllm 77 16 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 77 17 unit unit NN work_av4lzmkbbzda3hgvpstyfssllm 77 18 isolation isolation NN work_av4lzmkbbzda3hgvpstyfssllm 77 19 width width NN work_av4lzmkbbzda3hgvpstyfssllm 77 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 78 1 Fragmentation fragmentation NN work_av4lzmkbbzda3hgvpstyfssllm 78 2 data datum NNS work_av4lzmkbbzda3hgvpstyfssllm 78 3 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 78 4 screened screen VBN work_av4lzmkbbzda3hgvpstyfssllm 78 5 against against IN work_av4lzmkbbzda3hgvpstyfssllm 78 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 78 7 protein.nrdb protein.nrdb NNP work_av4lzmkbbzda3hgvpstyfssllm 78 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 78 9 Z Z NNP work_av4lzmkbbzda3hgvpstyfssllm 78 10 data- data- JJ work_av4lzmkbbzda3hgvpstyfssllm 78 11 base base NN work_av4lzmkbbzda3hgvpstyfssllm 78 12 from from IN work_av4lzmkbbzda3hgvpstyfssllm 78 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 78 14 Frederick Frederick NNP work_av4lzmkbbzda3hgvpstyfssllm 78 15 Biomedical Biomedical NNP work_av4lzmkbbzda3hgvpstyfssllm 78 16 Supercomputing Supercomputing NNP work_av4lzmkbbzda3hgvpstyfssllm 78 17 Center Center NNP work_av4lzmkbbzda3hgvpstyfssllm 78 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 78 19 ftp://ftp.ncifcrf.gov/pub/nonredun/ ftp://ftp.ncifcrf.gov/pub/nonredun/ NNP work_av4lzmkbbzda3hgvpstyfssllm 78 20 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 78 21 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 78 22 the the DT work_av4lzmkbbzda3hgvpstyfssllm 78 23 SEQUEST SEQUEST NNP work_av4lzmkbbzda3hgvpstyfssllm 78 24 Browser Browser NNP work_av4lzmkbbzda3hgvpstyfssllm 78 25 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 78 26 33 33 CD work_av4lzmkbbzda3hgvpstyfssllm 78 27 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 78 28 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 78 29 ThermoQuest ThermoQuest NNP work_av4lzmkbbzda3hgvpstyfssllm 78 30 Corp. Corp. NNP work_av4lzmkbbzda3hgvpstyfssllm 78 31 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 78 32 . . . work_av4lzmkbbzda3hgvpstyfssllm 79 1 Mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 79 2 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 79 3 by by IN work_av4lzmkbbzda3hgvpstyfssllm 79 4 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 79 5 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 79 6 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 79 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 79 8 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 79 9 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 79 10 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 79 11 extracted extract VBD work_av4lzmkbbzda3hgvpstyfssllm 79 12 RNA RNA NNP work_av4lzmkbbzda3hgvpstyfssllm 79 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 79 14 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 79 15 DNA dna NN work_av4lzmkbbzda3hgvpstyfssllm 79 16 from from IN work_av4lzmkbbzda3hgvpstyfssllm 79 17 cultured cultured JJ work_av4lzmkbbzda3hgvpstyfssllm 79 18 skin skin NN work_av4lzmkbbzda3hgvpstyfssllm 79 19 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 79 20 and/or and/or CC work_av4lzmkbbzda3hgvpstyfssllm 79 21 blood blood NN work_av4lzmkbbzda3hgvpstyfssllm 79 22 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 79 23 the the DT work_av4lzmkbbzda3hgvpstyfssllm 79 24 Puregene Puregene NNP work_av4lzmkbbzda3hgvpstyfssllm 79 25 RNA RNA NNP work_av4lzmkbbzda3hgvpstyfssllm 79 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 79 27 DNA dna NN work_av4lzmkbbzda3hgvpstyfssllm 79 28 isolation isolation NN work_av4lzmkbbzda3hgvpstyfssllm 79 29 kits kit NNS work_av4lzmkbbzda3hgvpstyfssllm 79 30 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 79 31 Gentra Gentra NNP work_av4lzmkbbzda3hgvpstyfssllm 79 32 Systems Systems NNP work_av4lzmkbbzda3hgvpstyfssllm 79 33 , , , work_av4lzmkbbzda3hgvpstyfssllm 79 34 Minneapolis Minneapolis NNP work_av4lzmkbbzda3hgvpstyfssllm 79 35 , , , work_av4lzmkbbzda3hgvpstyfssllm 79 36 Minnesota Minnesota NNP work_av4lzmkbbzda3hgvpstyfssllm 79 37 , , , work_av4lzmkbbzda3hgvpstyfssllm 79 38 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 79 39 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 79 40 and and CC work_av4lzmkbbzda3hgvpstyfssllm 79 41 performed perform VBD work_av4lzmkbbzda3hgvpstyfssllm 79 42 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 79 43 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 79 44 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 79 45 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 79 46 5–10 5–10 NNP work_av4lzmkbbzda3hgvpstyfssllm 79 47 µg µg IN work_av4lzmkbbzda3hgvpstyfssllm 79 48 fibroblast fibroblast NN work_av4lzmkbbzda3hgvpstyfssllm 79 49 RNA RNA NNP work_av4lzmkbbzda3hgvpstyfssllm 79 50 and and CC work_av4lzmkbbzda3hgvpstyfssllm 79 51 a a DT work_av4lzmkbbzda3hgvpstyfssllm 79 52 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 79 53 cycle cycle NN work_av4lzmkbbzda3hgvpstyfssllm 79 54 kit kit NN work_av4lzmkbbzda3hgvpstyfssllm 79 55 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 79 56 Invitrogen Invitrogen NNP work_av4lzmkbbzda3hgvpstyfssllm 79 57 Corp. Corp. NNP work_av4lzmkbbzda3hgvpstyfssllm 79 58 , , , work_av4lzmkbbzda3hgvpstyfssllm 79 59 Carlsbad Carlsbad NNP work_av4lzmkbbzda3hgvpstyfssllm 79 60 , , , work_av4lzmkbbzda3hgvpstyfssllm 79 61 California California NNP work_av4lzmkbbzda3hgvpstyfssllm 79 62 , , , work_av4lzmkbbzda3hgvpstyfssllm 79 63 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 79 64 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 79 65 following follow VBG work_av4lzmkbbzda3hgvpstyfssllm 79 66 the the DT work_av4lzmkbbzda3hgvpstyfssllm 79 67 manu- manu- NNP work_av4lzmkbbzda3hgvpstyfssllm 79 68 facturers facturers NNP work_av4lzmkbbzda3hgvpstyfssllm 79 69 ’ ’ POS work_av4lzmkbbzda3hgvpstyfssllm 79 70 recommendations recommendation NNS work_av4lzmkbbzda3hgvpstyfssllm 79 71 . . . work_av4lzmkbbzda3hgvpstyfssllm 80 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 80 2 generated generate VBD work_av4lzmkbbzda3hgvpstyfssllm 80 3 first first JJ work_av4lzmkbbzda3hgvpstyfssllm 80 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 80 5 strand strand NN work_av4lzmkbbzda3hgvpstyfssllm 80 6 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 80 7 with with IN work_av4lzmkbbzda3hgvpstyfssllm 80 8 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 80 9 DV4403 DV4403 NNP work_av4lzmkbbzda3hgvpstyfssllm 80 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 80 11 antisense antisense NNP work_av4lzmkbbzda3hgvpstyfssllm 80 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 80 13 5′-GACC- 5′-gacc- CD work_av4lzmkbbzda3hgvpstyfssllm 80 14 CAAATGCATGATTCTCC CAAATGCATGATTCTCC NNP work_av4lzmkbbzda3hgvpstyfssllm 80 15 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 80 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 80 17 complementary complementary JJ work_av4lzmkbbzda3hgvpstyfssllm 80 18 to to IN work_av4lzmkbbzda3hgvpstyfssllm 80 19 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 80 20 in in IN work_av4lzmkbbzda3hgvpstyfssllm 80 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 80 22 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 80 23 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 80 24 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 80 25 region region NN work_av4lzmkbbzda3hgvpstyfssllm 80 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 80 27 and and CC work_av4lzmkbbzda3hgvpstyfssllm 80 28 DV DV NNP work_av4lzmkbbzda3hgvpstyfssllm 80 29 4506 4506 CD work_av4lzmkbbzda3hgvpstyfssllm 80 30 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 80 31 antisense antisense NN work_av4lzmkbbzda3hgvpstyfssllm 80 32 , , , work_av4lzmkbbzda3hgvpstyfssllm 80 33 5′-GGTAGAAAAGTACAA 5′-ggtagaaaagtacaa CD work_av4lzmkbbzda3hgvpstyfssllm 80 34 TGCACAG TGCACAG NNP work_av4lzmkbbzda3hgvpstyfssllm 80 35 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 80 36 , , , work_av4lzmkbbzda3hgvpstyfssllm 80 37 complementary complementary JJ work_av4lzmkbbzda3hgvpstyfssllm 80 38 to to IN work_av4lzmkbbzda3hgvpstyfssllm 80 39 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 80 40 in in IN work_av4lzmkbbzda3hgvpstyfssllm 80 41 the the DT work_av4lzmkbbzda3hgvpstyfssllm 80 42 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 80 43 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 80 44 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 80 45 region region NN work_av4lzmkbbzda3hgvpstyfssllm 80 46 . . . work_av4lzmkbbzda3hgvpstyfssllm 81 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 81 2 then then RB work_av4lzmkbbzda3hgvpstyfssllm 81 3 ampli- ampli- VBP work_av4lzmkbbzda3hgvpstyfssllm 81 4 fied fie VBD work_av4lzmkbbzda3hgvpstyfssllm 81 5 first first JJ work_av4lzmkbbzda3hgvpstyfssllm 81 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 81 7 strand strand NN work_av4lzmkbbzda3hgvpstyfssllm 81 8 MCCA mcca NN work_av4lzmkbbzda3hgvpstyfssllm 81 9 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 81 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 81 11 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 81 12 DV4418 DV4418 NNP work_av4lzmkbbzda3hgvpstyfssllm 81 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 81 14 DV4446 dv4446 NN work_av4lzmkbbzda3hgvpstyfssllm 81 15 to to TO work_av4lzmkbbzda3hgvpstyfssllm 81 16 generate generate VB work_av4lzmkbbzda3hgvpstyfssllm 81 17 a a DT work_av4lzmkbbzda3hgvpstyfssllm 81 18 2,326-bp 2,326-bp CD work_av4lzmkbbzda3hgvpstyfssllm 81 19 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 81 20 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 81 21 – – : work_av4lzmkbbzda3hgvpstyfssllm 81 22 51 51 CD work_av4lzmkbbzda3hgvpstyfssllm 81 23 to to IN work_av4lzmkbbzda3hgvpstyfssllm 81 24 +2275 +2275 NNP work_av4lzmkbbzda3hgvpstyfssllm 81 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 81 26 where where WRB work_av4lzmkbbzda3hgvpstyfssllm 81 27 +1 +1 NNS work_av4lzmkbbzda3hgvpstyfssllm 81 28 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 81 29 the the DT work_av4lzmkbbzda3hgvpstyfssllm 81 30 A a NN work_av4lzmkbbzda3hgvpstyfssllm 81 31 of of IN work_av4lzmkbbzda3hgvpstyfssllm 81 32 the the DT work_av4lzmkbbzda3hgvpstyfssllm 81 33 initiation initiation NN work_av4lzmkbbzda3hgvpstyfssllm 81 34 methionine methionine NN work_av4lzmkbbzda3hgvpstyfssllm 81 35 codon codon NNP work_av4lzmkbbzda3hgvpstyfssllm 81 36 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 81 37 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 81 38 and and CC work_av4lzmkbbzda3hgvpstyfssllm 81 39 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 81 40 amplified amplify VBD work_av4lzmkbbzda3hgvpstyfssllm 81 41 first first JJ work_av4lzmkbbzda3hgvpstyfssllm 81 42 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 81 43 strand strand NNP work_av4lzmkbbzda3hgvpstyfssllm 81 44 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 81 45 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 81 46 with with IN work_av4lzmkbbzda3hgvpstyfssllm 81 47 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 81 48 DV4496 DV4496 . work_av4lzmkbbzda3hgvpstyfssllm 81 49 and and CC work_av4lzmkbbzda3hgvpstyfssllm 81 50 DV DV NNP work_av4lzmkbbzda3hgvpstyfssllm 81 51 4495 4495 CD work_av4lzmkbbzda3hgvpstyfssllm 81 52 to to TO work_av4lzmkbbzda3hgvpstyfssllm 81 53 generate generate VB work_av4lzmkbbzda3hgvpstyfssllm 81 54 a a DT work_av4lzmkbbzda3hgvpstyfssllm 81 55 1,923- 1,923- CD work_av4lzmkbbzda3hgvpstyfssllm 81 56 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 81 57 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 81 58 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 81 59 – – : work_av4lzmkbbzda3hgvpstyfssllm 81 60 99 99 CD work_av4lzmkbbzda3hgvpstyfssllm 81 61 to to IN work_av4lzmkbbzda3hgvpstyfssllm 81 62 +1824 +1824 '' work_av4lzmkbbzda3hgvpstyfssllm 81 63 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 81 64 . . . work_av4lzmkbbzda3hgvpstyfssllm 82 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 82 2 some some DT work_av4lzmkbbzda3hgvpstyfssllm 82 3 instances instance NNS work_av4lzmkbbzda3hgvpstyfssllm 82 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 82 5 when when WRB work_av4lzmkbbzda3hgvpstyfssllm 82 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 82 7 amount amount NN work_av4lzmkbbzda3hgvpstyfssllm 82 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 82 9 amplified amplified JJ work_av4lzmkbbzda3hgvpstyfssllm 82 10 product product NN work_av4lzmkbbzda3hgvpstyfssllm 82 11 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 82 12 inadequate inadequate JJ work_av4lzmkbbzda3hgvpstyfssllm 82 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 82 14 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 82 15 went go VBD work_av4lzmkbbzda3hgvpstyfssllm 82 16 through through IN work_av4lzmkbbzda3hgvpstyfssllm 82 17 a a DT work_av4lzmkbbzda3hgvpstyfssllm 82 18 second second JJ work_av4lzmkbbzda3hgvpstyfssllm 82 19 round round NN work_av4lzmkbbzda3hgvpstyfssllm 82 20 of of IN work_av4lzmkbbzda3hgvpstyfssllm 82 21 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 82 22 with with IN work_av4lzmkbbzda3hgvpstyfssllm 82 23 nested nested JJ work_av4lzmkbbzda3hgvpstyfssllm 82 24 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 82 25 DV4417 DV4417 NFP work_av4lzmkbbzda3hgvpstyfssllm 82 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 82 27 DV4497 DV4497 NNP work_av4lzmkbbzda3hgvpstyfssllm 82 28 . . . work_av4lzmkbbzda3hgvpstyfssllm 83 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 83 2 gel gel VBP work_av4lzmkbbzda3hgvpstyfssllm 83 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 83 4 purified purify VBD work_av4lzmkbbzda3hgvpstyfssllm 83 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 83 6 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 83 7 products product NNS work_av4lzmkbbzda3hgvpstyfssllm 83 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 83 9 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 83 10 them -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 83 11 directly directly RB work_av4lzmkbbzda3hgvpstyfssllm 83 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 84 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 84 2 confirm confirm VB work_av4lzmkbbzda3hgvpstyfssllm 84 3 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 84 4 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 84 5 in in IN work_av4lzmkbbzda3hgvpstyfssllm 84 6 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 84 7 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 84 8 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 84 9 products product NNS work_av4lzmkbbzda3hgvpstyfssllm 84 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 84 11 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 84 12 amplified amplify VBD work_av4lzmkbbzda3hgvpstyfssllm 84 13 a a DT work_av4lzmkbbzda3hgvpstyfssllm 84 14 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 84 15 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 84 16 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 84 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 84 18 corre- corre- NN work_av4lzmkbbzda3hgvpstyfssllm 84 19 sponding sponde VBG work_av4lzmkbbzda3hgvpstyfssllm 84 20 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 84 21 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 84 22 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 84 23 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 84 24 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 84 25 and and CC work_av4lzmkbbzda3hgvpstyfssllm 84 26 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 84 27 the the DT work_av4lzmkbbzda3hgvpstyfssllm 84 28 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 84 29 product product NN work_av4lzmkbbzda3hgvpstyfssllm 84 30 directly directly RB work_av4lzmkbbzda3hgvpstyfssllm 84 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 85 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 85 2 the the DT work_av4lzmkbbzda3hgvpstyfssllm 85 3 compound compound JJ work_av4lzmkbbzda3hgvpstyfssllm 85 4 heterozygous heterozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 85 5 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 85 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 85 7 whom whom WP work_av4lzmkbbzda3hgvpstyfssllm 85 8 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 85 9 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 85 10 only only RB work_av4lzmkbbzda3hgvpstyfssllm 85 11 one one CD work_av4lzmkbbzda3hgvpstyfssllm 85 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 85 13 two two CD work_av4lzmkbbzda3hgvpstyfssllm 85 14 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 85 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 85 16 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 85 17 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 85 18 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 85 19 products product NNS work_av4lzmkbbzda3hgvpstyfssllm 85 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 85 21 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 85 22 amplified amplify VBD work_av4lzmkbbzda3hgvpstyfssllm 85 23 and and CC work_av4lzmkbbzda3hgvpstyfssllm 85 24 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 85 25 all all DT work_av4lzmkbbzda3hgvpstyfssllm 85 26 exons exon NNS work_av4lzmkbbzda3hgvpstyfssllm 85 27 and and CC work_av4lzmkbbzda3hgvpstyfssllm 85 28 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 85 29 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 85 30 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 85 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 86 1 All all DT work_av4lzmkbbzda3hgvpstyfssllm 86 2 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 86 3 reactions reaction NNS work_av4lzmkbbzda3hgvpstyfssllm 86 4 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 86 5 50 50 CD work_av4lzmkbbzda3hgvpstyfssllm 86 6 µl µl IN work_av4lzmkbbzda3hgvpstyfssllm 86 7 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 86 8 contained contain VBN work_av4lzmkbbzda3hgvpstyfssllm 86 9 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 86 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 86 11 100 100 CD work_av4lzmkbbzda3hgvpstyfssllm 86 12 ng ng NNS work_av4lzmkbbzda3hgvpstyfssllm 86 13 each each DT work_av4lzmkbbzda3hgvpstyfssllm 86 14 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 86 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 86 16 1× 1× NNP work_av4lzmkbbzda3hgvpstyfssllm 86 17 standard standard JJ work_av4lzmkbbzda3hgvpstyfssllm 86 18 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 86 19 buffer buffer NN work_av4lzmkbbzda3hgvpstyfssllm 86 20 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 86 21 Life Life NNP work_av4lzmkbbzda3hgvpstyfssllm 86 22 Technologies Technologies NNPS work_av4lzmkbbzda3hgvpstyfssllm 86 23 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 86 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 86 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 86 26 dNTPs dNTPs NNP work_av4lzmkbbzda3hgvpstyfssllm 86 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 86 28 200 200 CD work_av4lzmkbbzda3hgvpstyfssllm 86 29 µM µM NNP work_av4lzmkbbzda3hgvpstyfssllm 86 30 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 86 31 , , , work_av4lzmkbbzda3hgvpstyfssllm 86 32 and and CC work_av4lzmkbbzda3hgvpstyfssllm 86 33 Taq Taq NNP work_av4lzmkbbzda3hgvpstyfssllm 86 34 polymerase polymerase NN work_av4lzmkbbzda3hgvpstyfssllm 86 35 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 86 36 2.5 2.5 CD work_av4lzmkbbzda3hgvpstyfssllm 86 37 U u NN work_av4lzmkbbzda3hgvpstyfssllm 86 38 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 86 39 Life Life NNP work_av4lzmkbbzda3hgvpstyfssllm 86 40 Tech- Tech- NNP work_av4lzmkbbzda3hgvpstyfssllm 86 41 nologies nologie NNS work_av4lzmkbbzda3hgvpstyfssllm 86 42 Inc. Inc. NNP work_av4lzmkbbzda3hgvpstyfssllm 86 43 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 86 44 . . . work_av4lzmkbbzda3hgvpstyfssllm 87 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 87 2 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 87 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 87 4 all all DT work_av4lzmkbbzda3hgvpstyfssllm 87 5 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 87 6 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 87 7 available available JJ work_av4lzmkbbzda3hgvpstyfssllm 87 8 upon upon IN work_av4lzmkbbzda3hgvpstyfssllm 87 9 request request NN work_av4lzmkbbzda3hgvpstyfssllm 87 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 88 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 88 2 survey survey VB work_av4lzmkbbzda3hgvpstyfssllm 88 3 a a DT work_av4lzmkbbzda3hgvpstyfssllm 88 4 control control NN work_av4lzmkbbzda3hgvpstyfssllm 88 5 population population NN work_av4lzmkbbzda3hgvpstyfssllm 88 6 for for IN work_av4lzmkbbzda3hgvpstyfssllm 88 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 88 8 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 88 9 mis- mis- NN work_av4lzmkbbzda3hgvpstyfssllm 88 10 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 88 11 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 88 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 88 13 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 88 14 amplified amplify VBD work_av4lzmkbbzda3hgvpstyfssllm 88 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 88 16 relevant relevant JJ work_av4lzmkbbzda3hgvpstyfssllm 88 17 exon exon NN work_av4lzmkbbzda3hgvpstyfssllm 88 18 from from IN work_av4lzmkbbzda3hgvpstyfssllm 88 19 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 88 20 DNA DNA NNP work_av4lzmkbbzda3hgvpstyfssllm 88 21 and and CC work_av4lzmkbbzda3hgvpstyfssllm 88 22 performed perform VBN work_av4lzmkbbzda3hgvpstyfssllm 88 23 allele allele NNP work_av4lzmkbbzda3hgvpstyfssllm 88 24 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 88 25 specific specific JJ work_av4lzmkbbzda3hgvpstyfssllm 88 26 oligonu- oligonu- NNP work_av4lzmkbbzda3hgvpstyfssllm 88 27 cleotide cleotide NN work_av4lzmkbbzda3hgvpstyfssllm 88 28 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 88 29 as as IN work_av4lzmkbbzda3hgvpstyfssllm 88 30 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 88 31 previously previously RB work_av4lzmkbbzda3hgvpstyfssllm 88 32 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 88 33 34 34 CD work_av4lzmkbbzda3hgvpstyfssllm 88 34 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 88 35 . . . work_av4lzmkbbzda3hgvpstyfssllm 89 1 Construction construction NN work_av4lzmkbbzda3hgvpstyfssllm 89 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 89 3 wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 89 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 89 5 type type NN work_av4lzmkbbzda3hgvpstyfssllm 89 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 89 7 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 89 8 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 89 9 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 89 10 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 89 11 B B NNP work_av4lzmkbbzda3hgvpstyfssllm 89 12 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 89 13 vectors vector VBZ work_av4lzmkbbzda3hgvpstyfssllm 89 14 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 89 15 TA TA NNP work_av4lzmkbbzda3hgvpstyfssllm 89 16 cloned clone VBD work_av4lzmkbbzda3hgvpstyfssllm 89 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 89 18 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 89 19 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 89 20 length length NN work_av4lzmkbbzda3hgvpstyfssllm 89 21 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 89 22 MCCA mcca NN work_av4lzmkbbzda3hgvpstyfssllm 89 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 89 24 – – : work_av4lzmkbbzda3hgvpstyfssllm 89 25 51 51 CD work_av4lzmkbbzda3hgvpstyfssllm 89 26 to to IN work_av4lzmkbbzda3hgvpstyfssllm 89 27 +2275 +2275 NNP work_av4lzmkbbzda3hgvpstyfssllm 89 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 89 29 and and CC work_av4lzmkbbzda3hgvpstyfssllm 89 30 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 89 31 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 89 32 – – : work_av4lzmkbbzda3hgvpstyfssllm 89 33 99 99 CD work_av4lzmkbbzda3hgvpstyfssllm 89 34 to to IN work_av4lzmkbbzda3hgvpstyfssllm 89 35 +1824 +1824 CD work_av4lzmkbbzda3hgvpstyfssllm 89 36 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 89 37 cDNAs cdnas ADD work_av4lzmkbbzda3hgvpstyfssllm 89 38 into into IN work_av4lzmkbbzda3hgvpstyfssllm 89 39 pCR pcr NN work_av4lzmkbbzda3hgvpstyfssllm 89 40 Blunt Blunt NNP work_av4lzmkbbzda3hgvpstyfssllm 89 41 II II NNP work_av4lzmkbbzda3hgvpstyfssllm 89 42 TOPO TOPO NNP work_av4lzmkbbzda3hgvpstyfssllm 89 43 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 89 44 Invitrogen Invitrogen NNP work_av4lzmkbbzda3hgvpstyfssllm 89 45 Corp. Corp. NNP work_av4lzmkbbzda3hgvpstyfssllm 89 46 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 89 47 . . . work_av4lzmkbbzda3hgvpstyfssllm 90 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 90 2 introduce introduce VB work_av4lzmkbbzda3hgvpstyfssllm 90 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 90 4 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 90 5 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 90 6 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 90 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 90 8 A289V A289V NNP work_av4lzmkbbzda3hgvpstyfssllm 90 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 90 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 90 11 L437P L437P NNP work_av4lzmkbbzda3hgvpstyfssllm 90 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 90 13 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 90 14 har- har- RB work_av4lzmkbbzda3hgvpstyfssllm 90 15 vested vest VBD work_av4lzmkbbzda3hgvpstyfssllm 90 16 an an DT work_av4lzmkbbzda3hgvpstyfssllm 90 17 896-bp 896-bp CD work_av4lzmkbbzda3hgvpstyfssllm 90 18 ACCI acci NN work_av4lzmkbbzda3hgvpstyfssllm 90 19 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 90 20 from from IN work_av4lzmkbbzda3hgvpstyfssllm 90 21 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 90 22 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 90 23 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 90 24 – – : work_av4lzmkbbzda3hgvpstyfssllm 90 25 ampli- ampli- NNP work_av4lzmkbbzda3hgvpstyfssllm 90 26 fied fie VBN work_av4lzmkbbzda3hgvpstyfssllm 90 27 patient patient JJ work_av4lzmkbbzda3hgvpstyfssllm 90 28 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 90 29 and and CC work_av4lzmkbbzda3hgvpstyfssllm 90 30 subcloned subclone VBD work_av4lzmkbbzda3hgvpstyfssllm 90 31 this this DT work_av4lzmkbbzda3hgvpstyfssllm 90 32 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 90 33 into into IN work_av4lzmkbbzda3hgvpstyfssllm 90 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 90 35 pMCCA pmcca JJ work_av4lzmkbbzda3hgvpstyfssllm 90 36 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 90 37 TOPO topo NN work_av4lzmkbbzda3hgvpstyfssllm 90 38 construct construct NN work_av4lzmkbbzda3hgvpstyfssllm 90 39 . . . work_av4lzmkbbzda3hgvpstyfssllm 91 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 91 2 then then RB work_av4lzmkbbzda3hgvpstyfssllm 91 3 transferred transfer VBD work_av4lzmkbbzda3hgvpstyfssllm 91 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 91 5 wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 91 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 91 7 type type NN work_av4lzmkbbzda3hgvpstyfssllm 91 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 91 9 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 91 10 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 91 11 constructs construct NNS work_av4lzmkbbzda3hgvpstyfssllm 91 12 into into IN work_av4lzmkbbzda3hgvpstyfssllm 91 13 a a DT work_av4lzmkbbzda3hgvpstyfssllm 91 14 mam- mam- JJ work_av4lzmkbbzda3hgvpstyfssllm 91 15 malian malian JJ work_av4lzmkbbzda3hgvpstyfssllm 91 16 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 91 17 vector vector NN work_av4lzmkbbzda3hgvpstyfssllm 91 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 91 19 pTracer pTracer NNP work_av4lzmkbbzda3hgvpstyfssllm 91 20 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 91 21 CMV2 CMV2 NNP work_av4lzmkbbzda3hgvpstyfssllm 91 22 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 91 23 Invitrogen- Invitrogen- NNP work_av4lzmkbbzda3hgvpstyfssllm 91 24 Corp. Corp. NNP work_av4lzmkbbzda3hgvpstyfssllm 91 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 91 26 at at IN work_av4lzmkbbzda3hgvpstyfssllm 91 27 the the DT work_av4lzmkbbzda3hgvpstyfssllm 91 28 EcoR EcoR NNS work_av4lzmkbbzda3hgvpstyfssllm 91 29 I -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 91 30 site site VBP work_av4lzmkbbzda3hgvpstyfssllm 91 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 92 1 This this DT work_av4lzmkbbzda3hgvpstyfssllm 92 2 vector vector NN work_av4lzmkbbzda3hgvpstyfssllm 92 3 contains contain VBZ work_av4lzmkbbzda3hgvpstyfssllm 92 4 a a DT work_av4lzmkbbzda3hgvpstyfssllm 92 5 green green JJ work_av4lzmkbbzda3hgvpstyfssllm 92 6 fluorescent fluorescent NN work_av4lzmkbbzda3hgvpstyfssllm 92 7 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 92 8 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 92 9 GFP GFP NNP work_av4lzmkbbzda3hgvpstyfssllm 92 10 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 92 11 gene gene NN work_av4lzmkbbzda3hgvpstyfssllm 92 12 fused fuse VBN work_av4lzmkbbzda3hgvpstyfssllm 92 13 to to IN work_av4lzmkbbzda3hgvpstyfssllm 92 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 92 15 Zeocin Zeocin NNP work_av4lzmkbbzda3hgvpstyfssllm 92 16 resistance resistance NN work_av4lzmkbbzda3hgvpstyfssllm 92 17 gene gene NN work_av4lzmkbbzda3hgvpstyfssllm 92 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 93 1 Similarly similarly RB work_av4lzmkbbzda3hgvpstyfssllm 93 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 93 3 to to TO work_av4lzmkbbzda3hgvpstyfssllm 93 4 introduce introduce VB work_av4lzmkbbzda3hgvpstyfssllm 93 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 93 6 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 93 7 mis- mis- NN work_av4lzmkbbzda3hgvpstyfssllm 93 8 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 93 9 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 93 10 E99Q E99Q NNP work_av4lzmkbbzda3hgvpstyfssllm 93 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 93 12 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 93 13 harvested harvest VBD work_av4lzmkbbzda3hgvpstyfssllm 93 14 a a DT work_av4lzmkbbzda3hgvpstyfssllm 93 15 193-bp 193-bp CD work_av4lzmkbbzda3hgvpstyfssllm 93 16 EcoN EcoN NNP work_av4lzmkbbzda3hgvpstyfssllm 93 17 I I NNP work_av4lzmkbbzda3hgvpstyfssllm 93 18 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 93 19 BstE BstE NNP work_av4lzmkbbzda3hgvpstyfssllm 93 20 II II NNP work_av4lzmkbbzda3hgvpstyfssllm 93 21 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 93 22 from from IN work_av4lzmkbbzda3hgvpstyfssllm 93 23 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 93 24 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 93 25 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 93 26 amplified amplify VBD work_av4lzmkbbzda3hgvpstyfssllm 93 27 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 93 28 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 93 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 93 30 subcloned subclone VBD work_av4lzmkbbzda3hgvpstyfssllm 93 31 this this DT work_av4lzmkbbzda3hgvpstyfssllm 93 32 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 93 33 into into IN work_av4lzmkbbzda3hgvpstyfssllm 93 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 93 35 pMCCB- pMCCB- NNP work_av4lzmkbbzda3hgvpstyfssllm 93 36 TOPO topo NN work_av4lzmkbbzda3hgvpstyfssllm 93 37 construct construct NN work_av4lzmkbbzda3hgvpstyfssllm 93 38 and and CC work_av4lzmkbbzda3hgvpstyfssllm 93 39 then then RB work_av4lzmkbbzda3hgvpstyfssllm 93 40 transferred transfer VBD work_av4lzmkbbzda3hgvpstyfssllm 93 41 the the DT work_av4lzmkbbzda3hgvpstyfssllm 93 42 wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 93 43 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 93 44 type type NN work_av4lzmkbbzda3hgvpstyfssllm 93 45 and and CC work_av4lzmkbbzda3hgvpstyfssllm 93 46 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 93 47 constructs construct NNS work_av4lzmkbbzda3hgvpstyfssllm 93 48 into into IN work_av4lzmkbbzda3hgvpstyfssllm 93 49 pTracer pTracer NNP work_av4lzmkbbzda3hgvpstyfssllm 93 50 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 93 51 CMV2 CMV2 NNP work_av4lzmkbbzda3hgvpstyfssllm 93 52 . . . work_av4lzmkbbzda3hgvpstyfssllm 94 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 94 2 intro- intro- VB work_av4lzmkbbzda3hgvpstyfssllm 94 3 duce duce VB work_av4lzmkbbzda3hgvpstyfssllm 94 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 94 5 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 94 6 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 94 7 mutations mutation VBZ work_av4lzmkbbzda3hgvpstyfssllm 94 8 S173L s173l CD work_av4lzmkbbzda3hgvpstyfssllm 94 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 94 10 V339 V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 94 11 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 94 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 94 13 R155C R155C NNP work_av4lzmkbbzda3hgvpstyfssllm 94 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 94 15 P310R P310R NNP work_av4lzmkbbzda3hgvpstyfssllm 94 16 and and CC work_av4lzmkbbzda3hgvpstyfssllm 94 17 R193C R193C NNP work_av4lzmkbbzda3hgvpstyfssllm 94 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 94 19 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 94 20 harvested harvest VBD work_av4lzmkbbzda3hgvpstyfssllm 94 21 a a DT work_av4lzmkbbzda3hgvpstyfssllm 94 22 965-bp 965-bp CD work_av4lzmkbbzda3hgvpstyfssllm 94 23 BstE BstE NNP work_av4lzmkbbzda3hgvpstyfssllm 94 24 II II NNP work_av4lzmkbbzda3hgvpstyfssllm 94 25 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 94 26 Sfi Sfi NNP work_av4lzmkbbzda3hgvpstyfssllm 94 27 I -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 94 28 fragment fragment VBP work_av4lzmkbbzda3hgvpstyfssllm 94 29 from from IN work_av4lzmkbbzda3hgvpstyfssllm 94 30 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 94 31 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 94 32 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 94 33 – – : work_av4lzmkbbzda3hgvpstyfssllm 94 34 amplified amplified JJ work_av4lzmkbbzda3hgvpstyfssllm 94 35 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 94 36 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 94 37 and and CC work_av4lzmkbbzda3hgvpstyfssllm 94 38 subcloned subclone VBD work_av4lzmkbbzda3hgvpstyfssllm 94 39 this this DT work_av4lzmkbbzda3hgvpstyfssllm 94 40 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 94 41 directly directly RB work_av4lzmkbbzda3hgvpstyfssllm 94 42 into into IN work_av4lzmkbbzda3hgvpstyfssllm 94 43 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 94 44 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 94 45 pTracer pTracer NNP work_av4lzmkbbzda3hgvpstyfssllm 94 46 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 94 47 CMV2 CMV2 NNP work_av4lzmkbbzda3hgvpstyfssllm 94 48 . . . work_av4lzmkbbzda3hgvpstyfssllm 95 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 95 2 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 95 3 all all DT work_av4lzmkbbzda3hgvpstyfssllm 95 4 constructs construct NNS work_av4lzmkbbzda3hgvpstyfssllm 95 5 in in IN work_av4lzmkbbzda3hgvpstyfssllm 95 6 both both DT work_av4lzmkbbzda3hgvpstyfssllm 95 7 directions direction NNS work_av4lzmkbbzda3hgvpstyfssllm 95 8 to to TO work_av4lzmkbbzda3hgvpstyfssllm 95 9 validate validate VB work_av4lzmkbbzda3hgvpstyfssllm 95 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 95 11 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 95 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 96 1 Transfections transfection NNS work_av4lzmkbbzda3hgvpstyfssllm 96 2 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 96 3 transformed transform VBD work_av4lzmkbbzda3hgvpstyfssllm 96 4 primary primary JJ work_av4lzmkbbzda3hgvpstyfssllm 96 5 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 96 6 from from IN work_av4lzmkbbzda3hgvpstyfssllm 96 7 proband proband NN work_av4lzmkbbzda3hgvpstyfssllm 96 8 010 010 CD work_av4lzmkbbzda3hgvpstyfssllm 96 9 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 96 10 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 96 11 for for IN work_av4lzmkbbzda3hgvpstyfssllm 96 12 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 96 13 Q421fs(+1 Q421fs(+1 NNP work_av4lzmkbbzda3hgvpstyfssllm 96 14 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 96 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 96 16 from from IN work_av4lzmkbbzda3hgvpstyfssllm 96 17 proband proband NNP work_av4lzmkbbzda3hgvpstyfssllm 96 18 001 001 CD work_av4lzmkbbzda3hgvpstyfssllm 96 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 96 20 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 96 21 for for IN work_av4lzmkbbzda3hgvpstyfssllm 96 22 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 96 23 S173L s173l CD work_av4lzmkbbzda3hgvpstyfssllm 96 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 96 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 96 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 96 27 from from IN work_av4lzmkbbzda3hgvpstyfssllm 96 28 a a DT work_av4lzmkbbzda3hgvpstyfssllm 96 29 con- con- NN work_av4lzmkbbzda3hgvpstyfssllm 96 30 trol trol NN work_av4lzmkbbzda3hgvpstyfssllm 96 31 as as IN work_av4lzmkbbzda3hgvpstyfssllm 96 32 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 96 33 previously previously RB work_av4lzmkbbzda3hgvpstyfssllm 96 34 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 96 35 34 34 CD work_av4lzmkbbzda3hgvpstyfssllm 96 36 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 96 37 . . . work_av4lzmkbbzda3hgvpstyfssllm 97 1 For for IN work_av4lzmkbbzda3hgvpstyfssllm 97 2 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 97 3 stud- stud- NNP work_av4lzmkbbzda3hgvpstyfssllm 97 4 ies ies NNP work_av4lzmkbbzda3hgvpstyfssllm 97 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 97 6 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 97 7 electroporated electroporate VBD work_av4lzmkbbzda3hgvpstyfssllm 97 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 97 9 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 97 10 constructs construct NNS work_av4lzmkbbzda3hgvpstyfssllm 97 11 into into IN work_av4lzmkbbzda3hgvpstyfssllm 97 12 transformed transform VBN work_av4lzmkbbzda3hgvpstyfssllm 97 13 cells cell NNS work_av4lzmkbbzda3hgvpstyfssllm 97 14 as as IN work_av4lzmkbbzda3hgvpstyfssllm 97 15 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 97 16 elsewhere elsewhere RB work_av4lzmkbbzda3hgvpstyfssllm 97 17 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 97 18 34 34 CD work_av4lzmkbbzda3hgvpstyfssllm 97 19 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 97 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 98 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 98 2 har- har- RB work_av4lzmkbbzda3hgvpstyfssllm 98 3 vested vest VBD work_av4lzmkbbzda3hgvpstyfssllm 98 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 98 5 cells cell NNS work_av4lzmkbbzda3hgvpstyfssllm 98 6 after after IN work_av4lzmkbbzda3hgvpstyfssllm 98 7 72 72 CD work_av4lzmkbbzda3hgvpstyfssllm 98 8 hours hour NNS work_av4lzmkbbzda3hgvpstyfssllm 98 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 98 10 measured measure VBN work_av4lzmkbbzda3hgvpstyfssllm 98 11 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 98 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 98 13 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 98 14 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 98 15 radioisotopically radioisotopically RB work_av4lzmkbbzda3hgvpstyfssllm 98 16 as as IN work_av4lzmkbbzda3hgvpstyfssllm 98 17 described describe VBN work_av4lzmkbbzda3hgvpstyfssllm 98 18 previously previously RB work_av4lzmkbbzda3hgvpstyfssllm 98 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 98 20 27 27 CD work_av4lzmkbbzda3hgvpstyfssllm 98 21 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 98 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 99 1 Our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 99 2 standard standard JJ work_av4lzmkbbzda3hgvpstyfssllm 99 3 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 99 4 assay assay NN work_av4lzmkbbzda3hgvpstyfssllm 99 5 enables enable VBZ work_av4lzmkbbzda3hgvpstyfssllm 99 6 us -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 99 7 to to TO work_av4lzmkbbzda3hgvpstyfssllm 99 8 reliably reliably RB work_av4lzmkbbzda3hgvpstyfssllm 99 9 detect detect VB work_av4lzmkbbzda3hgvpstyfssllm 99 10 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 99 11 as as RB work_av4lzmkbbzda3hgvpstyfssllm 99 12 low low JJ work_av4lzmkbbzda3hgvpstyfssllm 99 13 as as IN work_av4lzmkbbzda3hgvpstyfssllm 99 14 5–10 5–10 NNP work_av4lzmkbbzda3hgvpstyfssllm 99 15 pmol pmol NNP work_av4lzmkbbzda3hgvpstyfssllm 99 16 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 99 17 min min NNP work_av4lzmkbbzda3hgvpstyfssllm 99 18 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 99 19 mg mg NNP work_av4lzmkbbzda3hgvpstyfssllm 99 20 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 99 21 . . . work_av4lzmkbbzda3hgvpstyfssllm 100 1 All all PDT work_av4lzmkbbzda3hgvpstyfssllm 100 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 100 3 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 100 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 100 5 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 100 6 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 100 7 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 100 8 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 100 9 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 100 10 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 100 11 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 100 12 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 100 13 | | CD work_av4lzmkbbzda3hgvpstyfssllm 100 14 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 100 15 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 100 16 497 497 CD work_av4lzmkbbzda3hgvpstyfssllm 100 17 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 100 18 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 100 19 The the DT work_av4lzmkbbzda3hgvpstyfssllm 100 20 MCC mcc NN work_av4lzmkbbzda3hgvpstyfssllm 100 21 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 100 22 catalyzed catalyzed JJ work_av4lzmkbbzda3hgvpstyfssllm 100 23 reaction reaction NN work_av4lzmkbbzda3hgvpstyfssllm 100 24 and and CC work_av4lzmkbbzda3hgvpstyfssllm 100 25 its -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 100 26 position position NN work_av4lzmkbbzda3hgvpstyfssllm 100 27 in in IN work_av4lzmkbbzda3hgvpstyfssllm 100 28 the the DT work_av4lzmkbbzda3hgvpstyfssllm 100 29 leucine leucine NN work_av4lzmkbbzda3hgvpstyfssllm 100 30 catabol- catabol- NN work_av4lzmkbbzda3hgvpstyfssllm 100 31 ic ic NNP work_av4lzmkbbzda3hgvpstyfssllm 100 32 pathway pathway NNP work_av4lzmkbbzda3hgvpstyfssllm 100 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 101 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 101 2 dashed dash VBN work_av4lzmkbbzda3hgvpstyfssllm 101 3 arrow arrow NN work_av4lzmkbbzda3hgvpstyfssllm 101 4 indicates indicate VBZ work_av4lzmkbbzda3hgvpstyfssllm 101 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 101 6 metabolites metabolite NNS work_av4lzmkbbzda3hgvpstyfssllm 101 7 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 101 8 accu- accu- NN work_av4lzmkbbzda3hgvpstyfssllm 101 9 mulate mulate NN work_av4lzmkbbzda3hgvpstyfssllm 101 10 due due IN work_av4lzmkbbzda3hgvpstyfssllm 101 11 to to IN work_av4lzmkbbzda3hgvpstyfssllm 101 12 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 101 13 of of IN work_av4lzmkbbzda3hgvpstyfssllm 101 14 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 101 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 102 1 498 498 CD work_av4lzmkbbzda3hgvpstyfssllm 102 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 102 3 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 102 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 102 5 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 102 6 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 102 7 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 102 8 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 102 9 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 102 10 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 102 11 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 102 12 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 102 13 | | CD work_av4lzmkbbzda3hgvpstyfssllm 102 14 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 102 15 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 102 16 transfections transfection NNS work_av4lzmkbbzda3hgvpstyfssllm 102 17 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 102 18 in in IN work_av4lzmkbbzda3hgvpstyfssllm 102 19 duplicates duplicate NNS work_av4lzmkbbzda3hgvpstyfssllm 102 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 103 1 Transformed transform VBN work_av4lzmkbbzda3hgvpstyfssllm 103 2 fibrob- fibrob- NN work_av4lzmkbbzda3hgvpstyfssllm 103 3 lasts last VBZ work_av4lzmkbbzda3hgvpstyfssllm 103 4 from from IN work_av4lzmkbbzda3hgvpstyfssllm 103 5 an an DT work_av4lzmkbbzda3hgvpstyfssllm 103 6 unaffected unaffected JJ work_av4lzmkbbzda3hgvpstyfssllm 103 7 individual individual NN work_av4lzmkbbzda3hgvpstyfssllm 103 8 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 103 9 used use VBN work_av4lzmkbbzda3hgvpstyfssllm 103 10 as as IN work_av4lzmkbbzda3hgvpstyfssllm 103 11 con- con- NNP work_av4lzmkbbzda3hgvpstyfssllm 103 12 trol trol NN work_av4lzmkbbzda3hgvpstyfssllm 103 13 . . . work_av4lzmkbbzda3hgvpstyfssllm 104 1 Transfection transfection NN work_av4lzmkbbzda3hgvpstyfssllm 104 2 efficiency efficiency NN work_av4lzmkbbzda3hgvpstyfssllm 104 3 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 104 4 assessed assess VBN work_av4lzmkbbzda3hgvpstyfssllm 104 5 by by IN work_av4lzmkbbzda3hgvpstyfssllm 104 6 coexpress- coexpress- NN work_av4lzmkbbzda3hgvpstyfssllm 104 7 ing ing NNP work_av4lzmkbbzda3hgvpstyfssllm 104 8 GFP GFP NNP work_av4lzmkbbzda3hgvpstyfssllm 104 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 104 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 104 11 same same JJ work_av4lzmkbbzda3hgvpstyfssllm 104 12 construct construct NN work_av4lzmkbbzda3hgvpstyfssllm 104 13 . . . work_av4lzmkbbzda3hgvpstyfssllm 105 1 Results result NNS work_av4lzmkbbzda3hgvpstyfssllm 105 2 Genetic genetic JJ work_av4lzmkbbzda3hgvpstyfssllm 105 3 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 105 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 105 5 assignment assignment NN work_av4lzmkbbzda3hgvpstyfssllm 105 6 to to IN work_av4lzmkbbzda3hgvpstyfssllm 105 7 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 105 8 or or CC work_av4lzmkbbzda3hgvpstyfssllm 105 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 105 10 As as IN work_av4lzmkbbzda3hgvpstyfssllm 105 11 an an DT work_av4lzmkbbzda3hgvpstyfssllm 105 12 initial initial JJ work_av4lzmkbbzda3hgvpstyfssllm 105 13 step step NN work_av4lzmkbbzda3hgvpstyfssllm 105 14 in in IN work_av4lzmkbbzda3hgvpstyfssllm 105 15 defining define VBG work_av4lzmkbbzda3hgvpstyfssllm 105 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 105 17 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 105 18 basis basis NN work_av4lzmkbbzda3hgvpstyfssllm 105 19 of of IN work_av4lzmkbbzda3hgvpstyfssllm 105 20 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 105 21 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 105 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 105 23 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 105 24 performed perform VBD work_av4lzmkbbzda3hgvpstyfssllm 105 25 biochemical biochemical JJ work_av4lzmkbbzda3hgvpstyfssllm 105 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 105 27 somatic somatic JJ work_av4lzmkbbzda3hgvpstyfssllm 105 28 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 105 29 genetic genetic JJ work_av4lzmkbbzda3hgvpstyfssllm 105 30 studies study NNS work_av4lzmkbbzda3hgvpstyfssllm 105 31 with with IN work_av4lzmkbbzda3hgvpstyfssllm 105 32 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 105 33 from from IN work_av4lzmkbbzda3hgvpstyfssllm 105 34 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 105 35 MCC mcc NN work_av4lzmkbbzda3hgvpstyfssllm 105 36 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 105 37 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 105 38 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 105 39 . . . work_av4lzmkbbzda3hgvpstyfssllm 106 1 Using use VBG work_av4lzmkbbzda3hgvpstyfssllm 106 2 restoration restoration NN work_av4lzmkbbzda3hgvpstyfssllm 106 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 106 4 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 106 5 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 106 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 106 7 PEG peg NN work_av4lzmkbbzda3hgvpstyfssllm 106 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 106 9 induced induce VBN work_av4lzmkbbzda3hgvpstyfssllm 106 10 heterokaryons heterokaryon NNS work_av4lzmkbbzda3hgvpstyfssllm 106 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 106 12 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 106 13 as as IN work_av4lzmkbbzda3hgvpstyfssllm 106 14 an an DT work_av4lzmkbbzda3hgvpstyfssllm 106 15 end end NN work_av4lzmkbbzda3hgvpstyfssllm 106 16 point point NN work_av4lzmkbbzda3hgvpstyfssllm 106 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 106 18 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 106 19 defined define VBD work_av4lzmkbbzda3hgvpstyfssllm 106 20 two two CD work_av4lzmkbbzda3hgvpstyfssllm 106 21 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 106 22 groups group NNS work_av4lzmkbbzda3hgvpstyfssllm 106 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 106 24 CGs CGs NNP work_av4lzmkbbzda3hgvpstyfssllm 106 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 106 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 106 27 one one CD work_av4lzmkbbzda3hgvpstyfssllm 106 28 comprising comprise VBG work_av4lzmkbbzda3hgvpstyfssllm 106 29 eight eight CD work_av4lzmkbbzda3hgvpstyfssllm 106 30 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 106 31 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 106 32 MCC- MCC- NNP work_av4lzmkbbzda3hgvpstyfssllm 106 33 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 106 34 , , , work_av4lzmkbbzda3hgvpstyfssllm 106 35 001 001 CD work_av4lzmkbbzda3hgvpstyfssllm 106 36 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 106 37 008 008 CD work_av4lzmkbbzda3hgvpstyfssllm 106 38 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 106 39 and and CC work_av4lzmkbbzda3hgvpstyfssllm 106 40 the the DT work_av4lzmkbbzda3hgvpstyfssllm 106 41 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 106 42 , , , work_av4lzmkbbzda3hgvpstyfssllm 106 43 six six CD work_av4lzmkbbzda3hgvpstyfssllm 106 44 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 106 45 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 106 46 MCC- MCC- NNP work_av4lzmkbbzda3hgvpstyfssllm 106 47 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 106 48 , , , work_av4lzmkbbzda3hgvpstyfssllm 106 49 009 009 CD work_av4lzmkbbzda3hgvpstyfssllm 106 50 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 106 51 014 014 CD work_av4lzmkbbzda3hgvpstyfssllm 106 52 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 106 53 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 106 54 data datum NNS work_av4lzmkbbzda3hgvpstyfssllm 106 55 available available JJ work_av4lzmkbbzda3hgvpstyfssllm 106 56 upon upon IN work_av4lzmkbbzda3hgvpstyfssllm 106 57 request request NN work_av4lzmkbbzda3hgvpstyfssllm 106 58 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 106 59 . . . work_av4lzmkbbzda3hgvpstyfssllm 107 1 Given give VBN work_av4lzmkbbzda3hgvpstyfssllm 107 2 that that IN work_av4lzmkbbzda3hgvpstyfssllm 107 3 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 107 4 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 107 5 composed compose VBN work_av4lzmkbbzda3hgvpstyfssllm 107 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 107 7 αβ αβ NNP work_av4lzmkbbzda3hgvpstyfssllm 107 8 heteromers heteromer NNS work_av4lzmkbbzda3hgvpstyfssllm 107 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 107 10 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 107 11 antici- antici- VBP work_av4lzmkbbzda3hgvpstyfssllm 107 12 pated pat VBD work_av4lzmkbbzda3hgvpstyfssllm 107 13 that that IN work_av4lzmkbbzda3hgvpstyfssllm 107 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 107 15 two two CD work_av4lzmkbbzda3hgvpstyfssllm 107 16 CGs cg NNS work_av4lzmkbbzda3hgvpstyfssllm 107 17 likely likely RB work_av4lzmkbbzda3hgvpstyfssllm 107 18 corresponded correspond VBD work_av4lzmkbbzda3hgvpstyfssllm 107 19 to to IN work_av4lzmkbbzda3hgvpstyfssllm 107 20 muta- muta- JJ work_av4lzmkbbzda3hgvpstyfssllm 107 21 tions tion NNS work_av4lzmkbbzda3hgvpstyfssllm 107 22 in in IN work_av4lzmkbbzda3hgvpstyfssllm 107 23 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 107 24 encoding encode VBG work_av4lzmkbbzda3hgvpstyfssllm 107 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 107 26 α α NN work_av4lzmkbbzda3hgvpstyfssllm 107 27 and and CC work_av4lzmkbbzda3hgvpstyfssllm 107 28 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 107 29 subunits subunit NNS work_av4lzmkbbzda3hgvpstyfssllm 107 30 of of IN work_av4lzmkbbzda3hgvpstyfssllm 107 31 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 107 32 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 107 33 encoded encode VBN work_av4lzmkbbzda3hgvpstyfssllm 107 34 by by IN work_av4lzmkbbzda3hgvpstyfssllm 107 35 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 107 36 and and CC work_av4lzmkbbzda3hgvpstyfssllm 107 37 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 107 38 , , , work_av4lzmkbbzda3hgvpstyfssllm 107 39 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 107 40 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 107 41 . . . work_av4lzmkbbzda3hgvpstyfssllm 108 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 108 2 investigate investigate VB work_av4lzmkbbzda3hgvpstyfssllm 108 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 108 4 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 108 5 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 108 6 at at IN work_av4lzmkbbzda3hgvpstyfssllm 108 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 108 8 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 108 9 level level NN work_av4lzmkbbzda3hgvpstyfssllm 108 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 108 11 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 108 12 examined examine VBD work_av4lzmkbbzda3hgvpstyfssllm 108 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 108 14 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 108 15 of of IN work_av4lzmkbbzda3hgvpstyfssllm 108 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 108 17 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 108 18 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 108 19 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 108 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 108 21 covalently covalently RB work_av4lzmkbbzda3hgvpstyfssllm 108 22 bound bind VBN work_av4lzmkbbzda3hgvpstyfssllm 108 23 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 108 24 as as IN work_av4lzmkbbzda3hgvpstyfssllm 108 25 a a DT work_av4lzmkbbzda3hgvpstyfssllm 108 26 tag tag NN work_av4lzmkbbzda3hgvpstyfssllm 108 27 in in IN work_av4lzmkbbzda3hgvpstyfssllm 108 28 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 108 29 of of IN work_av4lzmkbbzda3hgvpstyfssllm 108 30 five five CD work_av4lzmkbbzda3hgvpstyfssllm 108 31 of of IN work_av4lzmkbbzda3hgvpstyfssllm 108 32 six six CD work_av4lzmkbbzda3hgvpstyfssllm 108 33 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 108 34 and and CC work_av4lzmkbbzda3hgvpstyfssllm 108 35 in in IN work_av4lzmkbbzda3hgvpstyfssllm 108 36 all all DT work_av4lzmkbbzda3hgvpstyfssllm 108 37 of of IN work_av4lzmkbbzda3hgvpstyfssllm 108 38 the the DT work_av4lzmkbbzda3hgvpstyfssllm 108 39 eight eight CD work_av4lzmkbbzda3hgvpstyfssllm 108 40 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 108 41 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 108 42 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 108 43 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 108 44 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 108 45 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 108 46 . . . work_av4lzmkbbzda3hgvpstyfssllm 109 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 109 2 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 109 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 109 4 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 109 5 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 109 6 not not RB work_av4lzmkbbzda3hgvpstyfssllm 109 7 detected detect VBN work_av4lzmkbbzda3hgvpstyfssllm 109 8 in in IN work_av4lzmkbbzda3hgvpstyfssllm 109 9 four four CD work_av4lzmkbbzda3hgvpstyfssllm 109 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 109 11 five five CD work_av4lzmkbbzda3hgvpstyfssllm 109 12 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 109 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 109 14 whereas whereas IN work_av4lzmkbbzda3hgvpstyfssllm 109 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 109 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 109 17 remaining remain VBG work_av4lzmkbbzda3hgvpstyfssllm 109 18 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 109 19 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 109 20 line line NN work_av4lzmkbbzda3hgvpstyfssllm 109 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 109 22 proband proband NNP work_av4lzmkbbzda3hgvpstyfssllm 109 23 011 011 CD work_av4lzmkbbzda3hgvpstyfssllm 109 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 109 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 109 26 the the DT work_av4lzmkbbzda3hgvpstyfssllm 109 27 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 109 28 band band NN work_av4lzmkbbzda3hgvpstyfssllm 109 29 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 109 30 at at IN work_av4lzmkbbzda3hgvpstyfssllm 109 31 least least JJS work_av4lzmkbbzda3hgvpstyfssllm 109 32 as as RB work_av4lzmkbbzda3hgvpstyfssllm 109 33 intense intense JJ work_av4lzmkbbzda3hgvpstyfssllm 109 34 as as IN work_av4lzmkbbzda3hgvpstyfssllm 109 35 in in IN work_av4lzmkbbzda3hgvpstyfssllm 109 36 controls control NNS work_av4lzmkbbzda3hgvpstyfssllm 109 37 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 109 38 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 109 39 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 109 40 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 109 41 . . . work_av4lzmkbbzda3hgvpstyfssllm 110 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 110 2 all all PDT work_av4lzmkbbzda3hgvpstyfssllm 110 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 110 4 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 110 5 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 110 6 extracts extract VBZ work_av4lzmkbbzda3hgvpstyfssllm 110 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 110 8 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 110 9 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 110 10 reduced reduce VBN work_av4lzmkbbzda3hgvpstyfssllm 110 11 but but CC work_av4lzmkbbzda3hgvpstyfssllm 110 12 present present JJ work_av4lzmkbbzda3hgvpstyfssllm 110 13 . . . work_av4lzmkbbzda3hgvpstyfssllm 111 1 These these DT work_av4lzmkbbzda3hgvpstyfssllm 111 2 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 111 3 suggested suggest VBD work_av4lzmkbbzda3hgvpstyfssllm 111 4 that that IN work_av4lzmkbbzda3hgvpstyfssllm 111 5 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 111 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 111 7 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 111 8 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 111 9 caused cause VBN work_av4lzmkbbzda3hgvpstyfssllm 111 10 by by IN work_av4lzmkbbzda3hgvpstyfssllm 111 11 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 111 12 in in IN work_av4lzmkbbzda3hgvpstyfssllm 111 13 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 111 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 111 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 111 16 by by IN work_av4lzmkbbzda3hgvpstyfssllm 111 17 exclusion exclusion NN work_av4lzmkbbzda3hgvpstyfssllm 111 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 111 19 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 111 20 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 111 21 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 111 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 111 23 by by IN work_av4lzmkbbzda3hgvpstyfssllm 111 24 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 111 25 in in IN work_av4lzmkbbzda3hgvpstyfssllm 111 26 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 111 27 . . . work_av4lzmkbbzda3hgvpstyfssllm 112 1 Identification identification NN work_av4lzmkbbzda3hgvpstyfssllm 112 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 112 3 mammalian mammalian JJ work_av4lzmkbbzda3hgvpstyfssllm 112 4 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 112 5 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 112 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 112 7 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 112 8 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 112 9 Database database NN work_av4lzmkbbzda3hgvpstyfssllm 112 10 search search NN work_av4lzmkbbzda3hgvpstyfssllm 112 11 . . . work_av4lzmkbbzda3hgvpstyfssllm 113 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 113 2 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 113 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 113 4 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 113 5 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 113 6 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 113 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 113 8 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 113 9 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 113 10 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 113 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 113 12 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 113 13 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 113 14 17 17 CD work_av4lzmkbbzda3hgvpstyfssllm 113 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 113 16 18 18 CD work_av4lzmkbbzda3hgvpstyfssllm 113 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 113 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 113 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 113 20 TBLASTN tblastn NN work_av4lzmkbbzda3hgvpstyfssllm 113 21 algorithm algorithm NN work_av4lzmkbbzda3hgvpstyfssllm 113 22 to to TO work_av4lzmkbbzda3hgvpstyfssllm 113 23 probe probe VB work_av4lzmkbbzda3hgvpstyfssllm 113 24 the the DT work_av4lzmkbbzda3hgvpstyfssllm 113 25 public public JJ work_av4lzmkbbzda3hgvpstyfssllm 113 26 EST EST NNP work_av4lzmkbbzda3hgvpstyfssllm 113 27 data- data- JJ work_av4lzmkbbzda3hgvpstyfssllm 113 28 bases basis NNS work_av4lzmkbbzda3hgvpstyfssllm 113 29 to to TO work_av4lzmkbbzda3hgvpstyfssllm 113 30 identify identify VB work_av4lzmkbbzda3hgvpstyfssllm 113 31 murine murine NNP work_av4lzmkbbzda3hgvpstyfssllm 113 32 and and CC work_av4lzmkbbzda3hgvpstyfssllm 113 33 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 113 34 cDNAs cdnas JJ work_av4lzmkbbzda3hgvpstyfssllm 113 35 encoding encode VBG work_av4lzmkbbzda3hgvpstyfssllm 113 36 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 113 37 MCCAs MCCAs NNPS work_av4lzmkbbzda3hgvpstyfssllm 113 38 and and CC work_av4lzmkbbzda3hgvpstyfssllm 113 39 MCCBs MCCBs NNPS work_av4lzmkbbzda3hgvpstyfssllm 113 40 . . . work_av4lzmkbbzda3hgvpstyfssllm 114 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 114 2 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 114 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 114 4 murine murine NN work_av4lzmkbbzda3hgvpstyfssllm 114 5 candidates candidate NNS work_av4lzmkbbzda3hgvpstyfssllm 114 6 to to TO work_av4lzmkbbzda3hgvpstyfssllm 114 7 assemble assemble VB work_av4lzmkbbzda3hgvpstyfssllm 114 8 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 114 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 114 10 length length NN work_av4lzmkbbzda3hgvpstyfssllm 114 11 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 114 12 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 114 13 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 114 14 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 114 15 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 114 16 GenBank GenBank NNP work_av4lzmkbbzda3hgvpstyfssllm 114 17 accession accession NN work_av4lzmkbbzda3hgvpstyfssllm 114 18 number number NN work_av4lzmkbbzda3hgvpstyfssllm 114 19 : : : work_av4lzmkbbzda3hgvpstyfssllm 114 20 MmMC- MmMC- NNP work_av4lzmkbbzda3hgvpstyfssllm 114 21 CA CA NNP work_av4lzmkbbzda3hgvpstyfssllm 114 22 : : : work_av4lzmkbbzda3hgvpstyfssllm 114 23 AF310338 AF310338 NNP work_av4lzmkbbzda3hgvpstyfssllm 114 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 114 25 and and CC work_av4lzmkbbzda3hgvpstyfssllm 114 26 the the DT work_av4lzmkbbzda3hgvpstyfssllm 114 27 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 114 28 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 114 29 ESTs est NNS work_av4lzmkbbzda3hgvpstyfssllm 114 30 to to TO work_av4lzmkbbzda3hgvpstyfssllm 114 31 design design VB work_av4lzmkbbzda3hgvpstyfssllm 114 32 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 114 33 corresponding correspond VBG work_av4lzmkbbzda3hgvpstyfssllm 114 34 to to IN work_av4lzmkbbzda3hgvpstyfssllm 114 35 the the DT work_av4lzmkbbzda3hgvpstyfssllm 114 36 predicted predict VBN work_av4lzmkbbzda3hgvpstyfssllm 114 37 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 114 38 and and CC work_av4lzmkbbzda3hgvpstyfssllm 114 39 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 114 40 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 114 41 of of IN work_av4lzmkbbzda3hgvpstyfssllm 114 42 the the DT work_av4lzmkbbzda3hgvpstyfssllm 114 43 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 114 44 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 114 45 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 114 46 and and CC work_av4lzmkbbzda3hgvpstyfssllm 114 47 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 114 48 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 114 49 . . . work_av4lzmkbbzda3hgvpstyfssllm 115 1 Using use VBG work_av4lzmkbbzda3hgvpstyfssllm 115 2 these these DT work_av4lzmkbbzda3hgvpstyfssllm 115 3 primer primer JJ work_av4lzmkbbzda3hgvpstyfssllm 115 4 pairs pair NNS work_av4lzmkbbzda3hgvpstyfssllm 115 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 115 6 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 115 7 amplified amplify VBD work_av4lzmkbbzda3hgvpstyfssllm 115 8 a a DT work_av4lzmkbbzda3hgvpstyfssllm 115 9 sin- sin- JJ work_av4lzmkbbzda3hgvpstyfssllm 115 10 gle gle JJ work_av4lzmkbbzda3hgvpstyfssllm 115 11 fragment fragment NN work_av4lzmkbbzda3hgvpstyfssllm 115 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 115 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 115 14 predicted predict VBN work_av4lzmkbbzda3hgvpstyfssllm 115 15 size size NN work_av4lzmkbbzda3hgvpstyfssllm 115 16 for for IN work_av4lzmkbbzda3hgvpstyfssllm 115 17 both both DT work_av4lzmkbbzda3hgvpstyfssllm 115 18 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 115 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 115 20 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 115 21 from from IN work_av4lzmkbbzda3hgvpstyfssllm 115 22 a a DT work_av4lzmkbbzda3hgvpstyfssllm 115 23 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 115 24 retina retina NNP work_av4lzmkbbzda3hgvpstyfssllm 115 25 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 115 26 library library NNP work_av4lzmkbbzda3hgvpstyfssllm 115 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 115 28 29 29 CD work_av4lzmkbbzda3hgvpstyfssllm 115 29 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 115 30 . . . work_av4lzmkbbzda3hgvpstyfssllm 116 1 Gen- Gen- NNP work_av4lzmkbbzda3hgvpstyfssllm 116 2 Bank Bank NNP work_av4lzmkbbzda3hgvpstyfssllm 116 3 accession accession NN work_av4lzmkbbzda3hgvpstyfssllm 116 4 numbers number NNS work_av4lzmkbbzda3hgvpstyfssllm 116 5 : : : work_av4lzmkbbzda3hgvpstyfssllm 116 6 HsMCCA HsMCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 116 7 : : : work_av4lzmkbbzda3hgvpstyfssllm 116 8 AF310339 af310339 ADD work_av4lzmkbbzda3hgvpstyfssllm 116 9 . . . work_av4lzmkbbzda3hgvpstyfssllm 117 1 HsM- HsM- `` work_av4lzmkbbzda3hgvpstyfssllm 117 2 CCB CCB NNP work_av4lzmkbbzda3hgvpstyfssllm 117 3 : : : work_av4lzmkbbzda3hgvpstyfssllm 117 4 AF301000 AF301000 NNP work_av4lzmkbbzda3hgvpstyfssllm 117 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 118 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 118 2 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 118 3 additional additional JJ work_av4lzmkbbzda3hgvpstyfssllm 118 4 ESTs est NNS work_av4lzmkbbzda3hgvpstyfssllm 118 5 to to TO work_av4lzmkbbzda3hgvpstyfssllm 118 6 extend extend VB work_av4lzmkbbzda3hgvpstyfssllm 118 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 118 8 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 118 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 118 10 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 118 11 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 118 12 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 118 13 . . . work_av4lzmkbbzda3hgvpstyfssllm 119 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 119 2 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 119 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 119 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 119 5 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 119 6 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 119 7 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 119 8 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 119 9 57 57 CD work_av4lzmkbbzda3hgvpstyfssllm 119 10 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 119 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 119 12 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 119 13 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 119 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 119 15 a a DT work_av4lzmkbbzda3hgvpstyfssllm 119 16 2,175-bp 2,175-bp CD work_av4lzmkbbzda3hgvpstyfssllm 119 17 ORF ORF NNP work_av4lzmkbbzda3hgvpstyfssllm 119 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 119 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 119 20 222 222 CD work_av4lzmkbbzda3hgvpstyfssllm 119 21 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 119 22 of of IN work_av4lzmkbbzda3hgvpstyfssllm 119 23 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 119 24 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 119 25 extending extend VBG work_av4lzmkbbzda3hgvpstyfssllm 119 26 to to IN work_av4lzmkbbzda3hgvpstyfssllm 119 27 a a DT work_av4lzmkbbzda3hgvpstyfssllm 119 28 polyadenylation polyadenylation NN work_av4lzmkbbzda3hgvpstyfssllm 119 29 signal signal NN work_av4lzmkbbzda3hgvpstyfssllm 119 30 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 119 31 AAUAAA AAUAAA NNP work_av4lzmkbbzda3hgvpstyfssllm 119 32 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 119 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 120 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 120 2 murine murine NN work_av4lzmkbbzda3hgvpstyfssllm 120 3 can- can- NN work_av4lzmkbbzda3hgvpstyfssllm 120 4 didate didate NN work_av4lzmkbbzda3hgvpstyfssllm 120 5 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 120 6 cDNA cDNA NNP work_av4lzmkbbzda3hgvpstyfssllm 120 7 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 120 8 42 42 CD work_av4lzmkbbzda3hgvpstyfssllm 120 9 bp bp NNS work_av4lzmkbbzda3hgvpstyfssllm 120 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 120 11 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 120 12 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 120 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 120 14 a a DT work_av4lzmkbbzda3hgvpstyfssllm 120 15 2,151-bp 2,151-bp CD work_av4lzmkbbzda3hgvpstyfssllm 120 16 ORF ORF NNP work_av4lzmkbbzda3hgvpstyfssllm 120 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 120 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 120 19 190 190 CD work_av4lzmkbbzda3hgvpstyfssllm 120 20 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 120 21 of of IN work_av4lzmkbbzda3hgvpstyfssllm 120 22 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 120 23 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 120 24 extending extend VBG work_av4lzmkbbzda3hgvpstyfssllm 120 25 to to IN work_av4lzmkbbzda3hgvpstyfssllm 120 26 a a DT work_av4lzmkbbzda3hgvpstyfssllm 120 27 probable probable JJ work_av4lzmkbbzda3hgvpstyfssllm 120 28 polyadenylation polyadenylation NN work_av4lzmkbbzda3hgvpstyfssllm 120 29 signal signal NN work_av4lzmkbbzda3hgvpstyfssllm 120 30 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 120 31 AUAAA AUAAA NNP work_av4lzmkbbzda3hgvpstyfssllm 120 32 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 120 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 121 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 121 2 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 121 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 121 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 121 5 amplified amplified JJ work_av4lzmkbbzda3hgvpstyfssllm 121 6 human human NNP work_av4lzmkbbzda3hgvpstyfssllm 121 7 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 121 8 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 121 9 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 121 10 99 99 CD work_av4lzmkbbzda3hgvpstyfssllm 121 11 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 121 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 121 13 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 121 14 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 121 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 121 16 a a DT work_av4lzmkbbzda3hgvpstyfssllm 121 17 1,689-bp 1,689-bp JJ work_av4lzmkbbzda3hgvpstyfssllm 121 18 ORF ORF NNP work_av4lzmkbbzda3hgvpstyfssllm 121 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 121 20 and and CC work_av4lzmkbbzda3hgvpstyfssllm 121 21 540 540 CD work_av4lzmkbbzda3hgvpstyfssllm 121 22 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 121 23 of of IN work_av4lzmkbbzda3hgvpstyfssllm 121 24 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 121 25 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 121 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 122 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 122 2 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 122 3 cDNAs cdna VBZ work_av4lzmkbbzda3hgvpstyfssllm 122 4 predict predict VBP work_av4lzmkbbzda3hgvpstyfssllm 122 5 a a DT work_av4lzmkbbzda3hgvpstyfssllm 122 6 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 122 7 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 122 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 122 9 725 725 CD work_av4lzmkbbzda3hgvpstyfssllm 122 10 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 122 11 acids acid NNS work_av4lzmkbbzda3hgvpstyfssllm 122 12 with with IN work_av4lzmkbbzda3hgvpstyfssllm 122 13 a a DT work_av4lzmkbbzda3hgvpstyfssllm 122 14 calculated calculated JJ work_av4lzmkbbzda3hgvpstyfssllm 122 15 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 122 16 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 122 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 122 18 80 80 CD work_av4lzmkbbzda3hgvpstyfssllm 122 19 kDa kDa NNS work_av4lzmkbbzda3hgvpstyfssllm 122 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 122 21 a a DT work_av4lzmkbbzda3hgvpstyfssllm 122 22 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 122 23 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 122 24 of of IN work_av4lzmkbbzda3hgvpstyfssllm 122 25 717 717 CD work_av4lzmkbbzda3hgvpstyfssllm 122 26 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 122 27 acids acid NNS work_av4lzmkbbzda3hgvpstyfssllm 122 28 with with IN work_av4lzmkbbzda3hgvpstyfssllm 122 29 a a DT work_av4lzmkbbzda3hgvpstyfssllm 122 30 calcu- calcu- NN work_av4lzmkbbzda3hgvpstyfssllm 122 31 lated late VBN work_av4lzmkbbzda3hgvpstyfssllm 122 32 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 122 33 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 122 34 of of IN work_av4lzmkbbzda3hgvpstyfssllm 122 35 79 79 CD work_av4lzmkbbzda3hgvpstyfssllm 122 36 kDa kDa NNS work_av4lzmkbbzda3hgvpstyfssllm 122 37 , , , work_av4lzmkbbzda3hgvpstyfssllm 122 38 and and CC work_av4lzmkbbzda3hgvpstyfssllm 122 39 a a DT work_av4lzmkbbzda3hgvpstyfssllm 122 40 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 122 41 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 122 42 of of IN work_av4lzmkbbzda3hgvpstyfssllm 122 43 563 563 CD work_av4lzmkbbzda3hgvpstyfssllm 122 44 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 122 45 acids acid NNS work_av4lzmkbbzda3hgvpstyfssllm 122 46 with with IN work_av4lzmkbbzda3hgvpstyfssllm 122 47 a a DT work_av4lzmkbbzda3hgvpstyfssllm 122 48 calculated calculated JJ work_av4lzmkbbzda3hgvpstyfssllm 122 49 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 122 50 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 122 51 of of IN work_av4lzmkbbzda3hgvpstyfssllm 122 52 61 61 CD work_av4lzmkbbzda3hgvpstyfssllm 122 53 kDa kDa NNS work_av4lzmkbbzda3hgvpstyfssllm 122 54 . . . work_av4lzmkbbzda3hgvpstyfssllm 123 1 Human human JJ work_av4lzmkbbzda3hgvpstyfssllm 123 2 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 123 3 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 123 4 84 84 CD work_av4lzmkbbzda3hgvpstyfssllm 123 5 % % NN work_av4lzmkbbzda3hgvpstyfssllm 123 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 123 7 45 45 CD work_av4lzmkbbzda3hgvpstyfssllm 123 8 % % NN work_av4lzmkbbzda3hgvpstyfssllm 123 9 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 123 10 to to IN work_av4lzmkbbzda3hgvpstyfssllm 123 11 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 123 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 123 13 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 123 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 123 15 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 123 16 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 123 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 123 18 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 123 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 123 20 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 123 21 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 123 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 123 23 . . . work_av4lzmkbbzda3hgvpstyfssllm 124 1 Human human JJ work_av4lzmkbbzda3hgvpstyfssllm 124 2 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 124 3 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 124 4 60 60 CD work_av4lzmkbbzda3hgvpstyfssllm 124 5 % % NN work_av4lzmkbbzda3hgvpstyfssllm 124 6 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 124 7 to to IN work_av4lzmkbbzda3hgvpstyfssllm 124 8 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 124 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 124 10 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 124 11 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 124 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 124 13 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 124 14 3b 3b NN work_av4lzmkbbzda3hgvpstyfssllm 124 15 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 124 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 125 1 Similar similar JJ work_av4lzmkbbzda3hgvpstyfssllm 125 2 to to IN work_av4lzmkbbzda3hgvpstyfssllm 125 3 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 125 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 125 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 125 6 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 125 7 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 125 8 contains contain VBZ work_av4lzmkbbzda3hgvpstyfssllm 125 9 an an DT work_av4lzmkbbzda3hgvpstyfssllm 125 10 NH2-terminal nh2-terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 125 11 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 125 12 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 125 13 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 125 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 125 15 a a DT work_av4lzmkbbzda3hgvpstyfssllm 125 16 COOH cooh NN work_av4lzmkbbzda3hgvpstyfssllm 125 17 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 125 18 terminal terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 125 19 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 125 20 carrier carrier NN work_av4lzmkbbzda3hgvpstyfssllm 125 21 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 125 22 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 125 23 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 125 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 125 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 126 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 126 2 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 126 3 carrier carrier NN work_av4lzmkbbzda3hgvpstyfssllm 126 4 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 126 5 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 126 6 centered center VBN work_av4lzmkbbzda3hgvpstyfssllm 126 7 on on IN work_av4lzmkbbzda3hgvpstyfssllm 126 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 126 9 motif motif NN work_av4lzmkbbzda3hgvpstyfssllm 126 10 AMKM AMKM NNS work_av4lzmkbbzda3hgvpstyfssllm 126 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 126 12 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 126 13 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 126 14 found find VBN work_av4lzmkbbzda3hgvpstyfssllm 126 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 126 16 most most RBS work_av4lzmkbbzda3hgvpstyfssllm 126 17 biotinylated biotinylate VBN work_av4lzmkbbzda3hgvpstyfssllm 126 18 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 126 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 126 20 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 126 21 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 126 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 126 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 126 24 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 126 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 126 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 127 1 Biotin Biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 127 2 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 127 3 covalently covalently RB work_av4lzmkbbzda3hgvpstyfssllm 127 4 attached attach VBN work_av4lzmkbbzda3hgvpstyfssllm 127 5 to to IN work_av4lzmkbbzda3hgvpstyfssllm 127 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 127 7 ε ε NN work_av4lzmkbbzda3hgvpstyfssllm 127 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 127 9 amino amino NN work_av4lzmkbbzda3hgvpstyfssllm 127 10 group group NN work_av4lzmkbbzda3hgvpstyfssllm 127 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 127 12 lysine lysine NNP work_av4lzmkbbzda3hgvpstyfssllm 127 13 681 681 CD work_av4lzmkbbzda3hgvpstyfssllm 127 14 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 127 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 127 16 ε ε NNP work_av4lzmkbbzda3hgvpstyfssllm 127 17 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 127 18 biotinyl biotinyl NN work_av4lzmkbbzda3hgvpstyfssllm 127 19 lysine lysine NNP work_av4lzmkbbzda3hgvpstyfssllm 127 20 amide amide NNP work_av4lzmkbbzda3hgvpstyfssllm 127 21 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 127 22 termed term VBN work_av4lzmkbbzda3hgvpstyfssllm 127 23 biocytin biocytin NN work_av4lzmkbbzda3hgvpstyfssllm 127 24 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 127 25 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 127 26 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 127 27 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 127 28 . . . work_av4lzmkbbzda3hgvpstyfssllm 128 1 As as IN work_av4lzmkbbzda3hgvpstyfssllm 128 2 with with IN work_av4lzmkbbzda3hgvpstyfssllm 128 3 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 128 4 biotin- biotin- JJ work_av4lzmkbbzda3hgvpstyfssllm 128 5 dependent dependent JJ work_av4lzmkbbzda3hgvpstyfssllm 128 6 carboxylases carboxylase NNS work_av4lzmkbbzda3hgvpstyfssllm 128 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 128 8 there there EX work_av4lzmkbbzda3hgvpstyfssllm 128 9 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 128 10 a a DT work_av4lzmkbbzda3hgvpstyfssllm 128 11 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 128 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 128 13 A)PM A)PM NNS work_av4lzmkbbzda3hgvpstyfssllm 128 14 motif motif NN work_av4lzmkbbzda3hgvpstyfssllm 128 15 29 29 CD work_av4lzmkbbzda3hgvpstyfssllm 128 16 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 128 17 NH2-terminal nh2-terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 128 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 128 19 a a DT work_av4lzmkbbzda3hgvpstyfssllm 128 20 hydrophobic hydrophobic JJ work_av4lzmkbbzda3hgvpstyfssllm 128 21 residue residue NN work_av4lzmkbbzda3hgvpstyfssllm 128 22 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 128 23 F714 F714 NNP work_av4lzmkbbzda3hgvpstyfssllm 128 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 128 25 33 33 CD work_av4lzmkbbzda3hgvpstyfssllm 128 26 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 128 27 31 31 CD work_av4lzmkbbzda3hgvpstyfssllm 128 28 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 128 29 COOH COOH NNP work_av4lzmkbbzda3hgvpstyfssllm 128 30 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 128 31 terminal terminal NN work_av4lzmkbbzda3hgvpstyfssllm 128 32 of of IN work_av4lzmkbbzda3hgvpstyfssllm 128 33 bio- bio- FW work_av4lzmkbbzda3hgvpstyfssllm 128 34 cytin cytin NNP work_av4lzmkbbzda3hgvpstyfssllm 128 35 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 128 36 35 35 CD work_av4lzmkbbzda3hgvpstyfssllm 128 37 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 128 38 . . . work_av4lzmkbbzda3hgvpstyfssllm 129 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 129 2 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 129 3 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 129 4 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 129 5 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 129 6 located locate VBN work_av4lzmkbbzda3hgvpstyfssllm 129 7 in in IN work_av4lzmkbbzda3hgvpstyfssllm 129 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 129 9 NH2-terminal nh2-terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 129 10 two two CD work_av4lzmkbbzda3hgvpstyfssllm 129 11 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 129 12 thirds third NNS work_av4lzmkbbzda3hgvpstyfssllm 129 13 of of IN work_av4lzmkbbzda3hgvpstyfssllm 129 14 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 129 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 129 16 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 129 17 linked link VBN work_av4lzmkbbzda3hgvpstyfssllm 129 18 to to IN work_av4lzmkbbzda3hgvpstyfssllm 129 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 129 20 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 129 21 carrier carrier NN work_av4lzmkbbzda3hgvpstyfssllm 129 22 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 129 23 by by IN work_av4lzmkbbzda3hgvpstyfssllm 129 24 a a DT work_av4lzmkbbzda3hgvpstyfssllm 129 25 less less RBR work_av4lzmkbbzda3hgvpstyfssllm 129 26 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 129 27 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 129 28 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 129 29 only only RB work_av4lzmkbbzda3hgvpstyfssllm 129 30 25 25 CD work_av4lzmkbbzda3hgvpstyfssllm 129 31 % % NN work_av4lzmkbbzda3hgvpstyfssllm 129 32 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 129 33 to to IN work_av4lzmkbbzda3hgvpstyfssllm 129 34 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 129 35 thaliana thaliana NNP work_av4lzmkbbzda3hgvpstyfssllm 129 36 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 129 37 427 427 CD work_av4lzmkbbzda3hgvpstyfssllm 129 38 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 129 39 664 664 CD work_av4lzmkbbzda3hgvpstyfssllm 129 40 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 129 41 “ " `` work_av4lzmkbbzda3hgvpstyfssllm 129 42 hinge hinge NN work_av4lzmkbbzda3hgvpstyfssllm 129 43 ” " '' work_av4lzmkbbzda3hgvpstyfssllm 129 44 region region NN work_av4lzmkbbzda3hgvpstyfssllm 129 45 of of IN work_av4lzmkbbzda3hgvpstyfssllm 129 46 residues residues NNP work_av4lzmkbbzda3hgvpstyfssllm 129 47 441 441 CD work_av4lzmkbbzda3hgvpstyfssllm 129 48 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 129 49 650 650 CD work_av4lzmkbbzda3hgvpstyfssllm 129 50 . . . work_av4lzmkbbzda3hgvpstyfssllm 130 1 Additionally additionally RB work_av4lzmkbbzda3hgvpstyfssllm 130 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 130 3 there there EX work_av4lzmkbbzda3hgvpstyfssllm 130 4 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 130 5 per- per- RB work_av4lzmkbbzda3hgvpstyfssllm 130 6 fect fect JJ work_av4lzmkbbzda3hgvpstyfssllm 130 7 conservation conservation NN work_av4lzmkbbzda3hgvpstyfssllm 130 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 130 9 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 130 10 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 130 11 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 130 12 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 130 13 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 130 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 130 15 asterisks asterisk VBZ work_av4lzmkbbzda3hgvpstyfssllm 130 16 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 130 17 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 130 18 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 130 19 highly highly RB work_av4lzmkbbzda3hgvpstyfssllm 130 20 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 130 21 among among IN work_av4lzmkbbzda3hgvpstyfssllm 130 22 all all DT work_av4lzmkbbzda3hgvpstyfssllm 130 23 biotin biotin RB work_av4lzmkbbzda3hgvpstyfssllm 130 24 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 130 25 dependent dependent JJ work_av4lzmkbbzda3hgvpstyfssllm 130 26 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 130 27 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 130 28 Expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 130 29 of of IN work_av4lzmkbbzda3hgvpstyfssllm 130 30 the the DT work_av4lzmkbbzda3hgvpstyfssllm 130 31 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 130 32 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 130 33 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 130 34 MCCα MCCα NNPS work_av4lzmkbbzda3hgvpstyfssllm 130 35 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 130 36 in in IN work_av4lzmkbbzda3hgvpstyfssllm 130 37 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 130 38 . . . work_av4lzmkbbzda3hgvpstyfssllm 131 1 Proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 131 2 in in IN work_av4lzmkbbzda3hgvpstyfssllm 131 3 mitochondrial mitochondrial NN work_av4lzmkbbzda3hgvpstyfssllm 131 4 enriched enrich VBN work_av4lzmkbbzda3hgvpstyfssllm 131 5 fractions fraction NNS work_av4lzmkbbzda3hgvpstyfssllm 131 6 from from IN work_av4lzmkbbzda3hgvpstyfssllm 131 7 cultured cultured JJ work_av4lzmkbbzda3hgvpstyfssllm 131 8 fibrob- fibrob- JJ work_av4lzmkbbzda3hgvpstyfssllm 131 9 lasts last NNS work_av4lzmkbbzda3hgvpstyfssllm 131 10 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 131 11 separated separate VBN work_av4lzmkbbzda3hgvpstyfssllm 131 12 by by IN work_av4lzmkbbzda3hgvpstyfssllm 131 13 SDS SDS NNP work_av4lzmkbbzda3hgvpstyfssllm 131 14 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 131 15 PAGE PAGE NNP work_av4lzmkbbzda3hgvpstyfssllm 131 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 131 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 131 18 the the DT work_av4lzmkbbzda3hgvpstyfssllm 131 19 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 131 20 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 131 21 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 131 22 sub- sub- JJ work_av4lzmkbbzda3hgvpstyfssllm 131 23 units unit NNS work_av4lzmkbbzda3hgvpstyfssllm 131 24 of of IN work_av4lzmkbbzda3hgvpstyfssllm 131 25 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 131 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 131 27 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 131 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 131 29 and and CC work_av4lzmkbbzda3hgvpstyfssllm 131 30 PC PC NNP work_av4lzmkbbzda3hgvpstyfssllm 131 31 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 131 32 detected detect VBN work_av4lzmkbbzda3hgvpstyfssllm 131 33 with with IN work_av4lzmkbbzda3hgvpstyfssllm 131 34 an an DT work_av4lzmkbbzda3hgvpstyfssllm 131 35 avidin avidin NNP work_av4lzmkbbzda3hgvpstyfssllm 131 36 alkaline alkaline NN work_av4lzmkbbzda3hgvpstyfssllm 131 37 phosphatase phosphatase NN work_av4lzmkbbzda3hgvpstyfssllm 131 38 conjugate conjugate NN work_av4lzmkbbzda3hgvpstyfssllm 131 39 . . . work_av4lzmkbbzda3hgvpstyfssllm 132 1 Most most RBS work_av4lzmkbbzda3hgvpstyfssllm 132 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 132 3 but but CC work_av4lzmkbbzda3hgvpstyfssllm 132 4 not not RB work_av4lzmkbbzda3hgvpstyfssllm 132 5 all all DT work_av4lzmkbbzda3hgvpstyfssllm 132 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 132 7 CG2-probands cg2-proband VBZ work_av4lzmkbbzda3hgvpstyfssllm 132 8 lack lack VBP work_av4lzmkbbzda3hgvpstyfssllm 132 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 132 10 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 132 11 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 132 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 132 13 while while IN work_av4lzmkbbzda3hgvpstyfssllm 132 14 it -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 132 15 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 132 16 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 132 17 in in IN work_av4lzmkbbzda3hgvpstyfssllm 132 18 all all DT work_av4lzmkbbzda3hgvpstyfssllm 132 19 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 132 20 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 132 21 . . . work_av4lzmkbbzda3hgvpstyfssllm 133 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 133 2 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 133 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 133 4 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 133 5 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 133 6 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 133 7 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 133 8 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 133 9 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 133 10 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 133 11 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 133 12 | | CD work_av4lzmkbbzda3hgvpstyfssllm 133 13 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 133 14 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 133 15 499 499 CD work_av4lzmkbbzda3hgvpstyfssllm 133 16 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 133 17 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 133 18 Sequence Sequence NNP work_av4lzmkbbzda3hgvpstyfssllm 133 19 alignment alignment NN work_av4lzmkbbzda3hgvpstyfssllm 133 20 of of IN work_av4lzmkbbzda3hgvpstyfssllm 133 21 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 133 22 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 133 23 and and CC work_av4lzmkbbzda3hgvpstyfssllm 133 24 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 133 25 with with IN work_av4lzmkbbzda3hgvpstyfssllm 133 26 orthologs ortholog NNS work_av4lzmkbbzda3hgvpstyfssllm 133 27 from from IN work_av4lzmkbbzda3hgvpstyfssllm 133 28 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 133 29 and and CC work_av4lzmkbbzda3hgvpstyfssllm 133 30 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 133 31 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 133 32 . . . work_av4lzmkbbzda3hgvpstyfssllm 134 1 Amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 134 2 acids acid NNS work_av4lzmkbbzda3hgvpstyfssllm 134 3 identical identical JJ work_av4lzmkbbzda3hgvpstyfssllm 134 4 to to IN work_av4lzmkbbzda3hgvpstyfssllm 134 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 134 6 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 134 7 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 134 8 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 134 9 highlighted highlight VBN work_av4lzmkbbzda3hgvpstyfssllm 134 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 135 1 Missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 135 2 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 135 3 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 135 4 in in IN work_av4lzmkbbzda3hgvpstyfssllm 135 5 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 135 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 135 7 defi- defi- JJ work_av4lzmkbbzda3hgvpstyfssllm 135 8 cient cient NN work_av4lzmkbbzda3hgvpstyfssllm 135 9 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 135 10 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 135 11 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 135 12 above above IN work_av4lzmkbbzda3hgvpstyfssllm 135 13 with with IN work_av4lzmkbbzda3hgvpstyfssllm 135 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 135 15 substituted substitute VBN work_av4lzmkbbzda3hgvpstyfssllm 135 16 amino amino NN work_av4lzmkbbzda3hgvpstyfssllm 135 17 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 135 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 136 1 Potential potential JJ work_av4lzmkbbzda3hgvpstyfssllm 136 2 cleavage cleavage NN work_av4lzmkbbzda3hgvpstyfssllm 136 3 sites site NNS work_av4lzmkbbzda3hgvpstyfssllm 136 4 for for IN work_av4lzmkbbzda3hgvpstyfssllm 136 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 136 6 NH2-terminal nh2-terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 136 7 mitochondrial mitochondrial NN work_av4lzmkbbzda3hgvpstyfssllm 136 8 leader leader NN work_av4lzmkbbzda3hgvpstyfssllm 136 9 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 136 10 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 136 11 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 136 12 by by IN work_av4lzmkbbzda3hgvpstyfssllm 136 13 vertical vertical JJ work_av4lzmkbbzda3hgvpstyfssllm 136 14 arrowheads arrowhead NNS work_av4lzmkbbzda3hgvpstyfssllm 136 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 137 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 137 2 a a LS work_av4lzmkbbzda3hgvpstyfssllm 137 3 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 137 4 Sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 137 5 align- align- NN work_av4lzmkbbzda3hgvpstyfssllm 137 6 ment ment JJ work_av4lzmkbbzda3hgvpstyfssllm 137 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 137 8 human human NN work_av4lzmkbbzda3hgvpstyfssllm 137 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 137 10 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 137 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 137 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 137 13 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 137 14 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 137 15 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 137 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 138 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 138 2 predicted predict VBN work_av4lzmkbbzda3hgvpstyfssllm 138 3 ATP- ATP- NNP work_av4lzmkbbzda3hgvpstyfssllm 138 4 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 138 5 site site NN work_av4lzmkbbzda3hgvpstyfssllm 138 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 138 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 138 8 NH2-terminal NH2-terminal NNP work_av4lzmkbbzda3hgvpstyfssllm 138 9 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 138 10 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 138 11 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 138 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 138 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 138 14 predicted predict VBN work_av4lzmkbbzda3hgvpstyfssllm 138 15 COOH COOH NNP work_av4lzmkbbzda3hgvpstyfssllm 138 16 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 138 17 terminal terminal NN work_av4lzmkbbzda3hgvpstyfssllm 138 18 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 138 19 carboxyl carboxyl NN work_av4lzmkbbzda3hgvpstyfssllm 138 20 carrier carrier NN work_av4lzmkbbzda3hgvpstyfssllm 138 21 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 138 22 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 138 23 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 138 24 by by IN work_av4lzmkbbzda3hgvpstyfssllm 138 25 solid solid JJ work_av4lzmkbbzda3hgvpstyfssllm 138 26 and and CC work_av4lzmkbbzda3hgvpstyfssllm 138 27 dashed dashed JJ work_av4lzmkbbzda3hgvpstyfssllm 138 28 over- over- NN work_av4lzmkbbzda3hgvpstyfssllm 138 29 lines line NNS work_av4lzmkbbzda3hgvpstyfssllm 138 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 138 31 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 138 32 . . . work_av4lzmkbbzda3hgvpstyfssllm 139 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 139 2 arrow arrow NN work_av4lzmkbbzda3hgvpstyfssllm 139 3 indi- indi- NN work_av4lzmkbbzda3hgvpstyfssllm 139 4 cates cat VBZ work_av4lzmkbbzda3hgvpstyfssllm 139 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 139 6 lysine lysine JJ work_av4lzmkbbzda3hgvpstyfssllm 139 7 residue residue NN work_av4lzmkbbzda3hgvpstyfssllm 139 8 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 139 9 links link VBZ work_av4lzmkbbzda3hgvpstyfssllm 139 10 covalently covalently RB work_av4lzmkbbzda3hgvpstyfssllm 139 11 to to IN work_av4lzmkbbzda3hgvpstyfssllm 139 12 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 139 13 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 139 14 biocytin biocytin NN work_av4lzmkbbzda3hgvpstyfssllm 139 15 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 139 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 140 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 140 2 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 140 3 marked mark VBN work_av4lzmkbbzda3hgvpstyfssllm 140 4 with with IN work_av4lzmkbbzda3hgvpstyfssllm 140 5 an an DT work_av4lzmkbbzda3hgvpstyfssllm 140 6 asterisk asterisk NN work_av4lzmkbbzda3hgvpstyfssllm 140 7 within within IN work_av4lzmkbbzda3hgvpstyfssllm 140 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 140 9 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 140 10 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 140 11 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 140 12 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 140 13 thought think VBN work_av4lzmkbbzda3hgvpstyfssllm 140 14 to to TO work_av4lzmkbbzda3hgvpstyfssllm 140 15 play play VB work_av4lzmkbbzda3hgvpstyfssllm 140 16 an an DT work_av4lzmkbbzda3hgvpstyfssllm 140 17 important important JJ work_av4lzmkbbzda3hgvpstyfssllm 140 18 role role NN work_av4lzmkbbzda3hgvpstyfssllm 140 19 in in IN work_av4lzmkbbzda3hgvpstyfssllm 140 20 catalysis catalysis NN work_av4lzmkbbzda3hgvpstyfssllm 140 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 140 22 36 36 CD work_av4lzmkbbzda3hgvpstyfssllm 140 23 , , , work_av4lzmkbbzda3hgvpstyfssllm 140 24 37 37 CD work_av4lzmkbbzda3hgvpstyfssllm 140 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 140 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 141 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 141 2 b b LS work_av4lzmkbbzda3hgvpstyfssllm 141 3 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 141 4 Sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 141 5 alignment alignment NN work_av4lzmkbbzda3hgvpstyfssllm 141 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 141 7 human human NN work_av4lzmkbbzda3hgvpstyfssllm 141 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 141 9 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 141 10 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 141 11 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 141 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 142 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 142 2 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 142 3 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 142 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 142 5 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 142 6 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 142 7 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 142 8 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 142 9 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 142 10 by by IN work_av4lzmkbbzda3hgvpstyfssllm 142 11 a a DT work_av4lzmkbbzda3hgvpstyfssllm 142 12 solid solid JJ work_av4lzmkbbzda3hgvpstyfssllm 142 13 over over IN work_av4lzmkbbzda3hgvpstyfssllm 142 14 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 142 15 line line NN work_av4lzmkbbzda3hgvpstyfssllm 142 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 143 1 500 500 CD work_av4lzmkbbzda3hgvpstyfssllm 143 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 143 3 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 143 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 143 5 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 143 6 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 143 7 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 143 8 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 143 9 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 143 10 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 143 11 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 143 12 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 143 13 | | CD work_av4lzmkbbzda3hgvpstyfssllm 143 14 Number Number NNP work_av4lzmkbbzda3hgvpstyfssllm 143 15 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 143 16 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 143 17 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 143 18 Coomassie Coomassie NNP work_av4lzmkbbzda3hgvpstyfssllm 143 19 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 143 20 stained stain VBN work_av4lzmkbbzda3hgvpstyfssllm 143 21 SDS SDS NNP work_av4lzmkbbzda3hgvpstyfssllm 143 22 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 143 23 PAGE PAGE NNP work_av4lzmkbbzda3hgvpstyfssllm 143 24 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 143 25 of of IN work_av4lzmkbbzda3hgvpstyfssllm 143 26 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 143 27 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 143 28 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 143 29 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 143 30 puri- puri- NN work_av4lzmkbbzda3hgvpstyfssllm 143 31 fied fie VBD work_av4lzmkbbzda3hgvpstyfssllm 143 32 from from IN work_av4lzmkbbzda3hgvpstyfssllm 143 33 a a DT work_av4lzmkbbzda3hgvpstyfssllm 143 34 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 143 35 kidney kidney NN work_av4lzmkbbzda3hgvpstyfssllm 143 36 extract extract NN work_av4lzmkbbzda3hgvpstyfssllm 143 37 with with IN work_av4lzmkbbzda3hgvpstyfssllm 143 38 streptavidin streptavidin NNP work_av4lzmkbbzda3hgvpstyfssllm 143 39 Dynabeads Dynabeads NNP work_av4lzmkbbzda3hgvpstyfssllm 143 40 . . . work_av4lzmkbbzda3hgvpstyfssllm 144 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 144 2 excised excise VBD work_av4lzmkbbzda3hgvpstyfssllm 144 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 144 4 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 144 5 from from IN work_av4lzmkbbzda3hgvpstyfssllm 144 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 144 7 gel gel NN work_av4lzmkbbzda3hgvpstyfssllm 144 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 144 9 digested digest VBN work_av4lzmkbbzda3hgvpstyfssllm 144 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 144 11 trypsin trypsin NNP work_av4lzmkbbzda3hgvpstyfssllm 144 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 144 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 144 14 analyzed analyze VBD work_av4lzmkbbzda3hgvpstyfssllm 144 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 144 16 tryptic tryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 144 17 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 144 18 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 144 19 MALDI MALDI NNP work_av4lzmkbbzda3hgvpstyfssllm 144 20 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 144 21 TOF TOF NNP work_av4lzmkbbzda3hgvpstyfssllm 144 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 144 23 liquid liquid JJ work_av4lzmkbbzda3hgvpstyfssllm 144 24 chromatography chromatography NN work_av4lzmkbbzda3hgvpstyfssllm 144 25 coupled couple VBN work_av4lzmkbbzda3hgvpstyfssllm 144 26 to to IN work_av4lzmkbbzda3hgvpstyfssllm 144 27 ESI ESI NNP work_av4lzmkbbzda3hgvpstyfssllm 144 28 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 144 29 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 144 30 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 144 31 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 144 32 . . . work_av4lzmkbbzda3hgvpstyfssllm 145 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 145 2 analyzed analyze VBD work_av4lzmkbbzda3hgvpstyfssllm 145 3 all all PDT work_av4lzmkbbzda3hgvpstyfssllm 145 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 145 5 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 145 6 bands band NNS work_av4lzmkbbzda3hgvpstyfssllm 145 7 includ- includ- NNP work_av4lzmkbbzda3hgvpstyfssllm 145 8 ing e VBG work_av4lzmkbbzda3hgvpstyfssllm 145 9 those those DT work_av4lzmkbbzda3hgvpstyfssllm 145 10 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 145 11 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 145 12 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 145 13 as as IN work_av4lzmkbbzda3hgvpstyfssllm 145 14 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 145 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 145 16 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 145 17 . . NNP work_av4lzmkbbzda3hgvpstyfssllm 145 18 carboxylases carboxylase NNS work_av4lzmkbbzda3hgvpstyfssllm 145 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 145 20 thought think VBD work_av4lzmkbbzda3hgvpstyfssllm 145 21 to to TO work_av4lzmkbbzda3hgvpstyfssllm 145 22 play play VB work_av4lzmkbbzda3hgvpstyfssllm 145 23 a a DT work_av4lzmkbbzda3hgvpstyfssllm 145 24 role role NN work_av4lzmkbbzda3hgvpstyfssllm 145 25 in in IN work_av4lzmkbbzda3hgvpstyfssllm 145 26 catalysis catalysis NN work_av4lzmkbbzda3hgvpstyfssllm 145 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 145 28 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 145 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 145 30 36 36 CD work_av4lzmkbbzda3hgvpstyfssllm 145 31 , , , work_av4lzmkbbzda3hgvpstyfssllm 145 32 37 37 CD work_av4lzmkbbzda3hgvpstyfssllm 145 33 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 145 34 . . . work_av4lzmkbbzda3hgvpstyfssllm 146 1 Consistent consistent JJ work_av4lzmkbbzda3hgvpstyfssllm 146 2 with with IN work_av4lzmkbbzda3hgvpstyfssllm 146 3 this this DT work_av4lzmkbbzda3hgvpstyfssllm 146 4 prediction prediction NN work_av4lzmkbbzda3hgvpstyfssllm 146 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 146 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 146 7 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 146 8 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 146 9 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 146 10 contains contain VBZ work_av4lzmkbbzda3hgvpstyfssllm 146 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 146 12 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 146 13 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 146 14 GGGGKGMRIV GGGGKGMRIV NNP work_av4lzmkbbzda3hgvpstyfssllm 146 15 at at IN work_av4lzmkbbzda3hgvpstyfssllm 146 16 positions position NNS work_av4lzmkbbzda3hgvpstyfssllm 146 17 209 209 CD work_av4lzmkbbzda3hgvpstyfssllm 146 18 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 146 19 218 218 CD work_av4lzmkbbzda3hgvpstyfssllm 146 20 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 146 21 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 146 22 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 146 23 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 146 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 146 25 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 146 26 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 146 27 part part NN work_av4lzmkbbzda3hgvpstyfssllm 146 28 of of IN work_av4lzmkbbzda3hgvpstyfssllm 146 29 the the DT work_av4lzmkbbzda3hgvpstyfssllm 146 30 ATP ATP NNP work_av4lzmkbbzda3hgvpstyfssllm 146 31 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 146 32 pocket pocket NN work_av4lzmkbbzda3hgvpstyfssllm 146 33 in in IN work_av4lzmkbbzda3hgvpstyfssllm 146 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 146 35 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 146 36 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 146 37 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 146 38 of of IN work_av4lzmkbbzda3hgvpstyfssllm 146 39 Escherichia Escherichia NNP work_av4lzmkbbzda3hgvpstyfssllm 146 40 coli coli NNS work_av4lzmkbbzda3hgvpstyfssllm 146 41 ACC ACC NNP work_av4lzmkbbzda3hgvpstyfssllm 146 42 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 146 43 37 37 CD work_av4lzmkbbzda3hgvpstyfssllm 146 44 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 146 45 and and CC work_av4lzmkbbzda3hgvpstyfssllm 146 46 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 146 47 similar similar JJ work_av4lzmkbbzda3hgvpstyfssllm 146 48 to to IN work_av4lzmkbbzda3hgvpstyfssllm 146 49 a a DT work_av4lzmkbbzda3hgvpstyfssllm 146 50 consensus consensus NN work_av4lzmkbbzda3hgvpstyfssllm 146 51 P p NN work_av4lzmkbbzda3hgvpstyfssllm 146 52 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 146 53 loop loop NNP work_av4lzmkbbzda3hgvpstyfssllm 146 54 ATP atp NN work_av4lzmkbbzda3hgvpstyfssllm 146 55 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 146 56 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 146 57 site site NN work_av4lzmkbbzda3hgvpstyfssllm 146 58 [ [ -LRB- work_av4lzmkbbzda3hgvpstyfssllm 146 59 G′XGK(TS G′XGK(TS NNP work_av4lzmkbbzda3hgvpstyfssllm 146 60 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 146 61 ] ] -RRB- work_av4lzmkbbzda3hgvpstyfssllm 146 62 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 146 63 38 38 CD work_av4lzmkbbzda3hgvpstyfssllm 146 64 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 146 65 . . . work_av4lzmkbbzda3hgvpstyfssllm 147 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 147 2 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 147 3 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 147 4 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 147 5 a a DT work_av4lzmkbbzda3hgvpstyfssllm 147 6 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 147 7 CoA coa NN work_av4lzmkbbzda3hgvpstyfssllm 147 8 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 147 9 motif motif NN work_av4lzmkbbzda3hgvpstyfssllm 147 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 147 11 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 147 12 3b 3b NN work_av4lzmkbbzda3hgvpstyfssllm 147 13 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 147 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 147 15 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 147 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 147 17 39 39 CD work_av4lzmkbbzda3hgvpstyfssllm 147 18 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 147 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 148 1 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 148 2 and and CC work_av4lzmkbbzda3hgvpstyfssllm 148 3 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 148 4 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 148 5 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 148 6 NH2-terminal NH2-terminal NNP work_av4lzmkbbzda3hgvpstyfssllm 148 7 mito- mito- NNP work_av4lzmkbbzda3hgvpstyfssllm 148 8 chondrial chondrial NNP work_av4lzmkbbzda3hgvpstyfssllm 148 9 targeting target VBG work_av4lzmkbbzda3hgvpstyfssllm 148 10 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 148 11 with with IN work_av4lzmkbbzda3hgvpstyfssllm 148 12 multiple multiple JJ work_av4lzmkbbzda3hgvpstyfssllm 148 13 arginine arginine NN work_av4lzmkbbzda3hgvpstyfssllm 148 14 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 148 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 148 16 a a DT work_av4lzmkbbzda3hgvpstyfssllm 148 17 paucity paucity NN work_av4lzmkbbzda3hgvpstyfssllm 148 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 148 19 acidic acidic JJ work_av4lzmkbbzda3hgvpstyfssllm 148 20 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 148 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 148 22 40 40 CD work_av4lzmkbbzda3hgvpstyfssllm 148 23 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 148 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 149 1 Possible possible JJ work_av4lzmkbbzda3hgvpstyfssllm 149 2 cleavage cleavage NN work_av4lzmkbbzda3hgvpstyfssllm 149 3 sites site NNS work_av4lzmkbbzda3hgvpstyfssllm 149 4 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 149 5 indicated indicate VBN work_av4lzmkbbzda3hgvpstyfssllm 149 6 by by IN work_av4lzmkbbzda3hgvpstyfssllm 149 7 vertical vertical JJ work_av4lzmkbbzda3hgvpstyfssllm 149 8 arrowheads arrowhead NNS work_av4lzmkbbzda3hgvpstyfssllm 149 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 149 10 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 149 11 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 149 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 150 1 Because because IN work_av4lzmkbbzda3hgvpstyfssllm 150 2 the the DT work_av4lzmkbbzda3hgvpstyfssllm 150 3 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 150 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 150 5 mitochondrial mitochondrial NN work_av4lzmkbbzda3hgvpstyfssllm 150 6 lead- lead- NNP work_av4lzmkbbzda3hgvpstyfssllm 150 7 ers ers NNP work_av4lzmkbbzda3hgvpstyfssllm 150 8 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 150 9 not not RB work_av4lzmkbbzda3hgvpstyfssllm 150 10 highly highly RB work_av4lzmkbbzda3hgvpstyfssllm 150 11 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 150 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 150 13 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 150 14 favor favor VBP work_av4lzmkbbzda3hgvpstyfssllm 150 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 150 16 more more RBR work_av4lzmkbbzda3hgvpstyfssllm 150 17 COOH- cooh- JJ work_av4lzmkbbzda3hgvpstyfssllm 150 18 terminal terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 150 19 cleavage cleavage NN work_av4lzmkbbzda3hgvpstyfssllm 150 20 site site NN work_av4lzmkbbzda3hgvpstyfssllm 150 21 in in IN work_av4lzmkbbzda3hgvpstyfssllm 150 22 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 150 23 just just RB work_av4lzmkbbzda3hgvpstyfssllm 150 24 before before IN work_av4lzmkbbzda3hgvpstyfssllm 150 25 a a DT work_av4lzmkbbzda3hgvpstyfssllm 150 26 highly highly RB work_av4lzmkbbzda3hgvpstyfssllm 150 27 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 150 28 region region NN work_av4lzmkbbzda3hgvpstyfssllm 150 29 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 150 30 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 150 31 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 150 32 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 150 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 151 1 Isolation isolation NN work_av4lzmkbbzda3hgvpstyfssllm 151 2 and and CC work_av4lzmkbbzda3hgvpstyfssllm 151 3 mass mass NN work_av4lzmkbbzda3hgvpstyfssllm 151 4 spectrometry spectrometry NN work_av4lzmkbbzda3hgvpstyfssllm 151 5 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 151 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 151 7 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 151 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 151 9 contain- contain- NN work_av4lzmkbbzda3hgvpstyfssllm 151 10 ing ing NNP work_av4lzmkbbzda3hgvpstyfssllm 151 11 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 151 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 152 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 152 2 also also RB work_av4lzmkbbzda3hgvpstyfssllm 152 3 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 152 4 a a DT work_av4lzmkbbzda3hgvpstyfssllm 152 5 biochemical biochemical JJ work_av4lzmkbbzda3hgvpstyfssllm 152 6 strategy strategy NN work_av4lzmkbbzda3hgvpstyfssllm 152 7 to to TO work_av4lzmkbbzda3hgvpstyfssllm 152 8 identify identify VB work_av4lzmkbbzda3hgvpstyfssllm 152 9 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 152 10 and and CC work_av4lzmkbbzda3hgvpstyfssllm 152 11 β β NN work_av4lzmkbbzda3hgvpstyfssllm 152 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 153 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 153 2 enriched enrich VBD work_av4lzmkbbzda3hgvpstyfssllm 153 3 biotin biotin RB work_av4lzmkbbzda3hgvpstyfssllm 153 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 153 5 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 153 6 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 153 7 in in IN work_av4lzmkbbzda3hgvpstyfssllm 153 8 a a DT work_av4lzmkbbzda3hgvpstyfssllm 153 9 mouse mouse NN work_av4lzmkbbzda3hgvpstyfssllm 153 10 kidney kidney NN work_av4lzmkbbzda3hgvpstyfssllm 153 11 extract extract NN work_av4lzmkbbzda3hgvpstyfssllm 153 12 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 153 13 streptavidin streptavidin NNP work_av4lzmkbbzda3hgvpstyfssllm 153 14 Dynabeads Dynabeads NNPS work_av4lzmkbbzda3hgvpstyfssllm 153 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 153 16 separated separate VBD work_av4lzmkbbzda3hgvpstyfssllm 153 17 these these DT work_av4lzmkbbzda3hgvpstyfssllm 153 18 by by IN work_av4lzmkbbzda3hgvpstyfssllm 153 19 SDS SDS NNP work_av4lzmkbbzda3hgvpstyfssllm 153 20 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 153 21 PAGE PAGE NNP work_av4lzmkbbzda3hgvpstyfssllm 153 22 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 153 23 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 153 24 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 153 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 153 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 154 1 Using use VBG work_av4lzmkbbzda3hgvpstyfssllm 154 2 MALDI MALDI NNP work_av4lzmkbbzda3hgvpstyfssllm 154 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 154 4 TOF TOF NNP work_av4lzmkbbzda3hgvpstyfssllm 154 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 154 6 electrospray electrospray NNP work_av4lzmkbbzda3hgvpstyfssllm 154 7 ionization ionization NN work_av4lzmkbbzda3hgvpstyfssllm 154 8 mass mass NNP work_av4lzmkbbzda3hgvpstyfssllm 154 9 spectrometry spectrometry NN work_av4lzmkbbzda3hgvpstyfssllm 154 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 154 11 ESI ESI NNP work_av4lzmkbbzda3hgvpstyfssllm 154 12 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 154 13 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 154 14 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 154 15 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 154 16 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 154 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 154 18 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 154 19 analyzed analyze VBD work_av4lzmkbbzda3hgvpstyfssllm 154 20 tryptic tryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 154 21 fragments fragment NNS work_av4lzmkbbzda3hgvpstyfssllm 154 22 of of IN work_av4lzmkbbzda3hgvpstyfssllm 154 23 these these DT work_av4lzmkbbzda3hgvpstyfssllm 154 24 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 154 25 to to TO work_av4lzmkbbzda3hgvpstyfssllm 154 26 confirm confirm VB work_av4lzmkbbzda3hgvpstyfssllm 154 27 the the DT work_av4lzmkbbzda3hgvpstyfssllm 154 28 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 154 29 expected expect VBN work_av4lzmkbbzda3hgvpstyfssllm 154 30 on on IN work_av4lzmkbbzda3hgvpstyfssllm 154 31 the the DT work_av4lzmkbbzda3hgvpstyfssllm 154 32 basis basis NN work_av4lzmkbbzda3hgvpstyfssllm 154 33 of of IN work_av4lzmkbbzda3hgvpstyfssllm 154 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 154 35 size size NN work_av4lzmkbbzda3hgvpstyfssllm 154 36 of of IN work_av4lzmkbbzda3hgvpstyfssllm 154 37 ACC ACC NNP work_av4lzmkbbzda3hgvpstyfssllm 154 38 , , , work_av4lzmkbbzda3hgvpstyfssllm 154 39 PC PC NNP work_av4lzmkbbzda3hgvpstyfssllm 154 40 , , , work_av4lzmkbbzda3hgvpstyfssllm 154 41 and and CC work_av4lzmkbbzda3hgvpstyfssllm 154 42 PCCβ PCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 154 43 . . . work_av4lzmkbbzda3hgvpstyfssllm 155 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 155 2 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 155 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 155 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 155 5 expected expect VBN work_av4lzmkbbzda3hgvpstyfssllm 155 6 PCCα PCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 155 7 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 155 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 155 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 155 10 addition addition NN work_av4lzmkbbzda3hgvpstyfssllm 155 11 to to IN work_av4lzmkbbzda3hgvpstyfssllm 155 12 fragments fragment NNS work_av4lzmkbbzda3hgvpstyfssllm 155 13 derived derive VBN work_av4lzmkbbzda3hgvpstyfssllm 155 14 from from IN work_av4lzmkbbzda3hgvpstyfssllm 155 15 PCCα PCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 155 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 155 17 unique unique JJ work_av4lzmkbbzda3hgvpstyfssllm 155 18 fragments fragment NNS work_av4lzmkbbzda3hgvpstyfssllm 155 19 corresponding correspond VBG work_av4lzmkbbzda3hgvpstyfssllm 155 20 to to IN work_av4lzmkbbzda3hgvpstyfssllm 155 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 155 22 conceptual conceptual JJ work_av4lzmkbbzda3hgvpstyfssllm 155 23 transla- transla- NN work_av4lzmkbbzda3hgvpstyfssllm 155 24 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 155 25 of of IN work_av4lzmkbbzda3hgvpstyfssllm 155 26 the the DT work_av4lzmkbbzda3hgvpstyfssllm 155 27 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 155 28 murine murine NN work_av4lzmkbbzda3hgvpstyfssllm 155 29 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 155 30 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 155 31 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 155 32 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 155 33 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 155 34 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 155 35 . . . work_av4lzmkbbzda3hgvpstyfssllm 156 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 156 2 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 156 3 35 35 CD work_av4lzmkbbzda3hgvpstyfssllm 156 4 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 156 5 with with IN work_av4lzmkbbzda3hgvpstyfssllm 156 6 100 100 CD work_av4lzmkbbzda3hgvpstyfssllm 156 7 % % NN work_av4lzmkbbzda3hgvpstyfssllm 156 8 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 156 9 to to IN work_av4lzmkbbzda3hgvpstyfssllm 156 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 156 11 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 156 12 murine murine NN work_av4lzmkbbzda3hgvpstyfssllm 156 13 MCCα MCCα NNPS work_av4lzmkbbzda3hgvpstyfssllm 156 14 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 156 15 covering cover VBG work_av4lzmkbbzda3hgvpstyfssllm 156 16 571 571 CD work_av4lzmkbbzda3hgvpstyfssllm 156 17 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 156 18 acids acid NNS work_av4lzmkbbzda3hgvpstyfssllm 156 19 or or CC work_av4lzmkbbzda3hgvpstyfssllm 156 20 80 80 CD work_av4lzmkbbzda3hgvpstyfssllm 156 21 % % NN work_av4lzmkbbzda3hgvpstyfssllm 156 22 of of IN work_av4lzmkbbzda3hgvpstyfssllm 156 23 the the DT work_av4lzmkbbzda3hgvpstyfssllm 156 24 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 156 25 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 156 26 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 156 27 length length NN work_av4lzmkbbzda3hgvpstyfssllm 156 28 murine murine NN work_av4lzmkbbzda3hgvpstyfssllm 156 29 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 156 30 . . . work_av4lzmkbbzda3hgvpstyfssllm 157 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 157 2 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 157 3 comigrating comigrate VBG work_av4lzmkbbzda3hgvpstyfssllm 157 4 with with IN work_av4lzmkbbzda3hgvpstyfssllm 157 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 157 6 66-kDa 66-kda CD work_av4lzmkbbzda3hgvpstyfssllm 157 7 marker marker NN work_av4lzmkbbzda3hgvpstyfssllm 157 8 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 157 9 Fig- Fig- NNP work_av4lzmkbbzda3hgvpstyfssllm 157 10 ure ure NNP work_av4lzmkbbzda3hgvpstyfssllm 157 11 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 157 12 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 157 13 contained contain VBD work_av4lzmkbbzda3hgvpstyfssllm 157 14 tryptic tryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 157 15 fragments fragment NNS work_av4lzmkbbzda3hgvpstyfssllm 157 16 with with IN work_av4lzmkbbzda3hgvpstyfssllm 157 17 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 157 18 cor- cor- RB work_av4lzmkbbzda3hgvpstyfssllm 157 19 responding respond VBG work_av4lzmkbbzda3hgvpstyfssllm 157 20 to to IN work_av4lzmkbbzda3hgvpstyfssllm 157 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 157 22 conceptual conceptual JJ work_av4lzmkbbzda3hgvpstyfssllm 157 23 translation translation NN work_av4lzmkbbzda3hgvpstyfssllm 157 24 of of IN work_av4lzmkbbzda3hgvpstyfssllm 157 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 157 26 puta- puta- NNP work_av4lzmkbbzda3hgvpstyfssllm 157 27 tive tive NNP work_av4lzmkbbzda3hgvpstyfssllm 157 28 human human NNP work_av4lzmkbbzda3hgvpstyfssllm 157 29 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 157 30 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 157 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 158 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 158 2 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 158 3 25 25 CD work_av4lzmkbbzda3hgvpstyfssllm 158 4 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 158 5 with with IN work_av4lzmkbbzda3hgvpstyfssllm 158 6 100 100 CD work_av4lzmkbbzda3hgvpstyfssllm 158 7 % % NN work_av4lzmkbbzda3hgvpstyfssllm 158 8 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 158 9 to to IN work_av4lzmkbbzda3hgvpstyfssllm 158 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 158 11 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 158 12 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 158 13 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 158 14 sub- sub- DT work_av4lzmkbbzda3hgvpstyfssllm 158 15 unit unit NN work_av4lzmkbbzda3hgvpstyfssllm 158 16 covering cover VBG work_av4lzmkbbzda3hgvpstyfssllm 158 17 414 414 CD work_av4lzmkbbzda3hgvpstyfssllm 158 18 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 158 19 acids acid NNS work_av4lzmkbbzda3hgvpstyfssllm 158 20 or or CC work_av4lzmkbbzda3hgvpstyfssllm 158 21 74 74 CD work_av4lzmkbbzda3hgvpstyfssllm 158 22 % % NN work_av4lzmkbbzda3hgvpstyfssllm 158 23 of of IN work_av4lzmkbbzda3hgvpstyfssllm 158 24 the the DT work_av4lzmkbbzda3hgvpstyfssllm 158 25 putative putative JJ work_av4lzmkbbzda3hgvpstyfssllm 158 26 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 158 27 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 158 28 length length NN work_av4lzmkbbzda3hgvpstyfssllm 158 29 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 158 30 . . . work_av4lzmkbbzda3hgvpstyfssllm 159 1 These these DT work_av4lzmkbbzda3hgvpstyfssllm 159 2 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 159 3 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 159 4 strongly strongly RB work_av4lzmkbbzda3hgvpstyfssllm 159 5 supported support VBD work_av4lzmkbbzda3hgvpstyfssllm 159 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 159 7 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 159 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 159 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 159 10 mammalian mammalian JJ work_av4lzmkbbzda3hgvpstyfssllm 159 11 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 159 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 159 13 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 159 14 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 159 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 160 1 Organization organization NN work_av4lzmkbbzda3hgvpstyfssllm 160 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 160 3 human human NNP work_av4lzmkbbzda3hgvpstyfssllm 160 4 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 160 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 160 6 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 160 7 structural structural JJ work_av4lzmkbbzda3hgvpstyfssllm 160 8 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 160 9 During during IN work_av4lzmkbbzda3hgvpstyfssllm 160 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 160 11 course course NN work_av4lzmkbbzda3hgvpstyfssllm 160 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 160 13 determining determine VBG work_av4lzmkbbzda3hgvpstyfssllm 160 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 160 15 structural structural JJ work_av4lzmkbbzda3hgvpstyfssllm 160 16 organization organization NN work_av4lzmkbbzda3hgvpstyfssllm 160 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 160 18 these these DT work_av4lzmkbbzda3hgvpstyfssllm 160 19 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 160 20 by by IN work_av4lzmkbbzda3hgvpstyfssllm 160 21 long long JJ work_av4lzmkbbzda3hgvpstyfssllm 160 22 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 160 23 range range NN work_av4lzmkbbzda3hgvpstyfssllm 160 24 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 160 25 and and CC work_av4lzmkbbzda3hgvpstyfssllm 160 26 direct direct JJ work_av4lzmkbbzda3hgvpstyfssllm 160 27 sequencing sequencing NN work_av4lzmkbbzda3hgvpstyfssllm 160 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 160 29 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 160 30 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 160 31 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 160 32 correspon- correspon- NN work_av4lzmkbbzda3hgvpstyfssllm 160 33 ding de VBG work_av4lzmkbbzda3hgvpstyfssllm 160 34 to to IN work_av4lzmkbbzda3hgvpstyfssllm 160 35 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 160 36 and and CC work_av4lzmkbbzda3hgvpstyfssllm 160 37 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 160 38 in in IN work_av4lzmkbbzda3hgvpstyfssllm 160 39 the the DT work_av4lzmkbbzda3hgvpstyfssllm 160 40 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 160 41 high high JJ work_av4lzmkbbzda3hgvpstyfssllm 160 42 through- through- NN work_av4lzmkbbzda3hgvpstyfssllm 160 43 out out RP work_av4lzmkbbzda3hgvpstyfssllm 160 44 genome genome JJ work_av4lzmkbbzda3hgvpstyfssllm 160 45 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 160 46 database database NN work_av4lzmkbbzda3hgvpstyfssllm 160 47 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 160 48 GenBank GenBank NNP work_av4lzmkbbzda3hgvpstyfssllm 160 49 accession accession NN work_av4lzmkbbzda3hgvpstyfssllm 160 50 numbers number NNS work_av4lzmkbbzda3hgvpstyfssllm 160 51 AC026920 ac026920 NN work_av4lzmkbbzda3hgvpstyfssllm 160 52 and and CC work_av4lzmkbbzda3hgvpstyfssllm 160 53 AC026775 ac026775 NN work_av4lzmkbbzda3hgvpstyfssllm 160 54 , , , work_av4lzmkbbzda3hgvpstyfssllm 160 55 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 160 56 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 160 57 . . . work_av4lzmkbbzda3hgvpstyfssllm 161 1 These these DT work_av4lzmkbbzda3hgvpstyfssllm 161 2 clones clone NNS work_av4lzmkbbzda3hgvpstyfssllm 161 3 contain contain VBP work_av4lzmkbbzda3hgvpstyfssllm 161 4 exons exon NNS work_av4lzmkbbzda3hgvpstyfssllm 161 5 encoding encode VBG work_av4lzmkbbzda3hgvpstyfssllm 161 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 161 7 complete complete JJ work_av4lzmkbbzda3hgvpstyfssllm 161 8 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 161 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 161 10 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 161 11 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 161 12 and and CC work_av4lzmkbbzda3hgvpstyfssllm 161 13 provide provide VB work_av4lzmkbbzda3hgvpstyfssllm 161 14 all all DT work_av4lzmkbbzda3hgvpstyfssllm 161 15 exon exon JJ work_av4lzmkbbzda3hgvpstyfssllm 161 16 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 161 17 intron intron NN work_av4lzmkbbzda3hgvpstyfssllm 161 18 boundaries boundary NNS work_av4lzmkbbzda3hgvpstyfssllm 161 19 including include VBG work_av4lzmkbbzda3hgvpstyfssllm 161 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 161 21 flanking flanking JJ work_av4lzmkbbzda3hgvpstyfssllm 161 22 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 161 23 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 161 24 with with IN work_av4lzmkbbzda3hgvpstyfssllm 161 25 one one CD work_av4lzmkbbzda3hgvpstyfssllm 161 26 exception exception NN work_av4lzmkbbzda3hgvpstyfssllm 161 27 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 161 28 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 161 29 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 161 30 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 161 31 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 161 32 of of IN work_av4lzmkbbzda3hgvpstyfssllm 161 33 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 161 34 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 161 35 8) 8) CD work_av4lzmkbbzda3hgvpstyfssllm 161 36 . . . work_av4lzmkbbzda3hgvpstyfssllm 162 1 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 162 2 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 162 3 19 19 CD work_av4lzmkbbzda3hgvpstyfssllm 162 4 exons exon NNS work_av4lzmkbbzda3hgvpstyfssllm 162 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 162 6 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 162 7 17 17 CD work_av4lzmkbbzda3hgvpstyfssllm 162 8 exons exon NNS work_av4lzmkbbzda3hgvpstyfssllm 162 9 . . . work_av4lzmkbbzda3hgvpstyfssllm 163 1 Given give VBN work_av4lzmkbbzda3hgvpstyfssllm 163 2 that that IN work_av4lzmkbbzda3hgvpstyfssllm 163 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 163 4 draft draft NN work_av4lzmkbbzda3hgvpstyfssllm 163 5 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 163 6 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 163 7 gaps gap NNS work_av4lzmkbbzda3hgvpstyfssllm 163 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 163 9 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 163 10 information information NN work_av4lzmkbbzda3hgvpstyfssllm 163 11 on on IN work_av4lzmkbbzda3hgvpstyfssllm 163 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 163 13 size size NN work_av4lzmkbbzda3hgvpstyfssllm 163 14 of of IN work_av4lzmkbbzda3hgvpstyfssllm 163 15 some some DT work_av4lzmkbbzda3hgvpstyfssllm 163 16 introns intron NNS work_av4lzmkbbzda3hgvpstyfssllm 163 17 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 163 18 incomplete incomplete JJ work_av4lzmkbbzda3hgvpstyfssllm 163 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 164 1 Because because IN work_av4lzmkbbzda3hgvpstyfssllm 164 2 the the DT work_av4lzmkbbzda3hgvpstyfssllm 164 3 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 164 4 gene gene NN work_av4lzmkbbzda3hgvpstyfssllm 164 5 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 164 6 not not RB work_av4lzmkbbzda3hgvpstyfssllm 164 7 mapped map VBN work_av4lzmkbbzda3hgvpstyfssllm 164 8 in in IN work_av4lzmkbbzda3hgvpstyfssllm 164 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 164 10 Uni- Uni- NNP work_av4lzmkbbzda3hgvpstyfssllm 164 11 Gene Gene NNP work_av4lzmkbbzda3hgvpstyfssllm 164 12 database database NN work_av4lzmkbbzda3hgvpstyfssllm 164 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 164 14 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 164 15 searched search VBD work_av4lzmkbbzda3hgvpstyfssllm 164 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 164 17 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 164 18 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 164 19 in in IN work_av4lzmkbbzda3hgvpstyfssllm 164 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 164 21 BAC BAC NNP work_av4lzmkbbzda3hgvpstyfssllm 164 22 clone clone NN work_av4lzmkbbzda3hgvpstyfssllm 164 23 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 164 24 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 164 25 for for IN work_av4lzmkbbzda3hgvpstyfssllm 164 26 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 164 27 mapped map VBN work_av4lzmkbbzda3hgvpstyfssllm 164 28 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 164 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 165 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 165 2 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 165 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 165 4 UniGene UniGene NNP work_av4lzmkbbzda3hgvpstyfssllm 165 5 cluster cluster NN work_av4lzmkbbzda3hgvpstyfssllm 165 6 Hs.10887 Hs.10887 NNS work_av4lzmkbbzda3hgvpstyfssllm 165 7 represented represent VBN work_av4lzmkbbzda3hgvpstyfssllm 165 8 by by IN work_av4lzmkbbzda3hgvpstyfssllm 165 9 several several JJ work_av4lzmkbbzda3hgvpstyfssllm 165 10 ESTs est NNS work_av4lzmkbbzda3hgvpstyfssllm 165 11 present present JJ work_av4lzmkbbzda3hgvpstyfssllm 165 12 in in IN work_av4lzmkbbzda3hgvpstyfssllm 165 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 165 14 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 165 15 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 165 16 clone clone NN work_av4lzmkbbzda3hgvpstyfssllm 165 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 165 18 localized localize VBD work_av4lzmkbbzda3hgvpstyfssllm 165 19 to to IN work_av4lzmkbbzda3hgvpstyfssllm 165 20 3q25-q27 3q25-q27 NNS work_av4lzmkbbzda3hgvpstyfssllm 165 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 165 22 D3S1553- D3S1553- NNP work_av4lzmkbbzda3hgvpstyfssllm 165 23 D3S1580 D3S1580 NNPS work_av4lzmkbbzda3hgvpstyfssllm 165 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 165 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 166 1 To to TO work_av4lzmkbbzda3hgvpstyfssllm 166 2 confirm confirm VB work_av4lzmkbbzda3hgvpstyfssllm 166 3 this this DT work_av4lzmkbbzda3hgvpstyfssllm 166 4 localization localization NN work_av4lzmkbbzda3hgvpstyfssllm 166 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 166 6 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 166 7 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 166 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 166 9 Genebridge Genebridge NNP work_av4lzmkbbzda3hgvpstyfssllm 166 10 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 166 11 radiation radiation NN work_av4lzmkbbzda3hgvpstyfssllm 166 12 hybrid hybrid JJ work_av4lzmkbbzda3hgvpstyfssllm 166 13 panel panel NN work_av4lzmkbbzda3hgvpstyfssllm 166 14 to to TO work_av4lzmkbbzda3hgvpstyfssllm 166 15 regionally regionally RB work_av4lzmkbbzda3hgvpstyfssllm 166 16 localize localize VB work_av4lzmkbbzda3hgvpstyfssllm 166 17 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 166 18 3.56 3.56 CD work_av4lzmkbbzda3hgvpstyfssllm 166 19 cR cR NNP work_av4lzmkbbzda3hgvpstyfssllm 166 20 from from IN work_av4lzmkbbzda3hgvpstyfssllm 166 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 166 22 WI-6365 WI-6365 NNP work_av4lzmkbbzda3hgvpstyfssllm 166 23 marker marker NN work_av4lzmkbbzda3hgvpstyfssllm 166 24 cor- cor- IN work_av4lzmkbbzda3hgvpstyfssllm 166 25 responding respond VBG work_av4lzmkbbzda3hgvpstyfssllm 166 26 to to IN work_av4lzmkbbzda3hgvpstyfssllm 166 27 the the DT work_av4lzmkbbzda3hgvpstyfssllm 166 28 same same JJ work_av4lzmkbbzda3hgvpstyfssllm 166 29 region region NN work_av4lzmkbbzda3hgvpstyfssllm 166 30 on on IN work_av4lzmkbbzda3hgvpstyfssllm 166 31 chromosome chromosome NN work_av4lzmkbbzda3hgvpstyfssllm 166 32 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 166 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 167 1 Similarly similarly RB work_av4lzmkbbzda3hgvpstyfssllm 167 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 167 3 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 167 4 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 167 5 UniGene UniGene NNP work_av4lzmkbbzda3hgvpstyfssllm 167 6 cluster cluster NN work_av4lzmkbbzda3hgvpstyfssllm 167 7 Hs.167531 hs.167531 NN work_av4lzmkbbzda3hgvpstyfssllm 167 8 representing represent VBG work_av4lzmkbbzda3hgvpstyfssllm 167 9 several several JJ work_av4lzmkbbzda3hgvpstyfssllm 167 10 EST EST NNP work_av4lzmkbbzda3hgvpstyfssllm 167 11 clones clone NNS work_av4lzmkbbzda3hgvpstyfssllm 167 12 covering cover VBG work_av4lzmkbbzda3hgvpstyfssllm 167 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 167 14 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 167 15 end end NN work_av4lzmkbbzda3hgvpstyfssllm 167 16 of of IN work_av4lzmkbbzda3hgvpstyfssllm 167 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 167 18 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 167 19 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 167 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 168 1 This this DT work_av4lzmkbbzda3hgvpstyfssllm 168 2 cluster cluster NN work_av4lzmkbbzda3hgvpstyfssllm 168 3 maps map VBZ work_av4lzmkbbzda3hgvpstyfssllm 168 4 to to TO work_av4lzmkbbzda3hgvpstyfssllm 168 5 chromosome chromosome VB work_av4lzmkbbzda3hgvpstyfssllm 168 6 5q12-q13.1 5q12-q13.1 CD work_av4lzmkbbzda3hgvpstyfssllm 168 7 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 168 8 D5S637-D5S1977 D5S637-D5S1977 NNP work_av4lzmkbbzda3hgvpstyfssllm 168 9 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 168 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 169 1 Patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 169 2 with with IN work_av4lzmkbbzda3hgvpstyfssllm 169 3 isolated isolated JJ work_av4lzmkbbzda3hgvpstyfssllm 169 4 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 169 5 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 169 6 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 169 7 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 169 8 in in IN work_av4lzmkbbzda3hgvpstyfssllm 169 9 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 169 10 or or CC work_av4lzmkbbzda3hgvpstyfssllm 169 11 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 169 12 To to TO work_av4lzmkbbzda3hgvpstyfssllm 169 13 confirm confirm VB work_av4lzmkbbzda3hgvpstyfssllm 169 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 169 15 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 169 16 of of IN work_av4lzmkbbzda3hgvpstyfssllm 169 17 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 169 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 169 19 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 169 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 169 21 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 169 22 sur- sur- VBP work_av4lzmkbbzda3hgvpstyfssllm 169 23 veyed veye VBD work_av4lzmkbbzda3hgvpstyfssllm 169 24 these these DT work_av4lzmkbbzda3hgvpstyfssllm 169 25 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 169 26 for for IN work_av4lzmkbbzda3hgvpstyfssllm 169 27 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 169 28 in in IN work_av4lzmkbbzda3hgvpstyfssllm 169 29 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 169 30 collection collection NN work_av4lzmkbbzda3hgvpstyfssllm 169 31 of of IN work_av4lzmkbbzda3hgvpstyfssllm 169 32 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 169 33 unrelated unrelated JJ work_av4lzmkbbzda3hgvpstyfssllm 169 34 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 169 35 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 169 36 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 169 37 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 169 38 . . . work_av4lzmkbbzda3hgvpstyfssllm 170 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 170 2 grouped group VBD work_av4lzmkbbzda3hgvpstyfssllm 170 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 170 4 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 170 5 according accord VBG work_av4lzmkbbzda3hgvpstyfssllm 170 6 to to IN work_av4lzmkbbzda3hgvpstyfssllm 170 7 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 170 8 CGs cg NNS work_av4lzmkbbzda3hgvpstyfssllm 170 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 170 10 used use VBN work_av4lzmkbbzda3hgvpstyfssllm 170 11 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 170 12 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 170 13 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 170 14 to to TO work_av4lzmkbbzda3hgvpstyfssllm 170 15 amplify amplify VB work_av4lzmkbbzda3hgvpstyfssllm 170 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 170 17 corresponding corresponding JJ work_av4lzmkbbzda3hgvpstyfssllm 170 18 mRNA mrna NN work_av4lzmkbbzda3hgvpstyfssllm 170 19 from from IN work_av4lzmkbbzda3hgvpstyfssllm 170 20 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 170 21 cultured cultured JJ work_av4lzmkbbzda3hgvpstyfssllm 170 22 skin skin NN work_av4lzmkbbzda3hgvpstyfssllm 170 23 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 170 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 171 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 171 2 sequenced sequence VBD work_av4lzmkbbzda3hgvpstyfssllm 171 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 171 4 entire entire JJ work_av4lzmkbbzda3hgvpstyfssllm 171 5 ORF ORF NNP work_av4lzmkbbzda3hgvpstyfssllm 171 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 171 7 each each DT work_av4lzmkbbzda3hgvpstyfssllm 171 8 proband proband NN work_av4lzmkbbzda3hgvpstyfssllm 171 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 171 10 confirmed confirm VBD work_av4lzmkbbzda3hgvpstyfssllm 171 11 all all DT work_av4lzmkbbzda3hgvpstyfssllm 171 12 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 171 13 by by IN work_av4lzmkbbzda3hgvpstyfssllm 171 14 direct direct JJ work_av4lzmkbbzda3hgvpstyfssllm 171 15 sequencing sequencing NN work_av4lzmkbbzda3hgvpstyfssllm 171 16 of of IN work_av4lzmkbbzda3hgvpstyfssllm 171 17 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 171 18 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 171 19 amplified amplify VBN work_av4lzmkbbzda3hgvpstyfssllm 171 20 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 171 21 DNA DNA NNP work_av4lzmkbbzda3hgvpstyfssllm 171 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 172 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 172 2 two two CD work_av4lzmkbbzda3hgvpstyfssllm 172 3 additional additional JJ work_av4lzmkbbzda3hgvpstyfssllm 172 4 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 172 5 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 172 6 015 015 CD work_av4lzmkbbzda3hgvpstyfssllm 172 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 172 8 016 016 CD work_av4lzmkbbzda3hgvpstyfssllm 172 9 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 172 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 172 11 ref ref NN work_av4lzmkbbzda3hgvpstyfssllm 172 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 173 1 4 4 LS work_av4lzmkbbzda3hgvpstyfssllm 173 2 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 173 3 from from IN work_av4lzmkbbzda3hgvpstyfssllm 173 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 173 5 Amish amish JJ work_av4lzmkbbzda3hgvpstyfssllm 173 6 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 173 7 Mennonite Mennonite NNP work_av4lzmkbbzda3hgvpstyfssllm 173 8 population population NN work_av4lzmkbbzda3hgvpstyfssllm 173 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 173 10 Lancaster Lancaster NNP work_av4lzmkbbzda3hgvpstyfssllm 173 11 County County NNP work_av4lzmkbbzda3hgvpstyfssllm 173 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 173 13 Pennsylvania Pennsylvania NNP work_av4lzmkbbzda3hgvpstyfssllm 173 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 173 15 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 173 16 searched search VBD work_av4lzmkbbzda3hgvpstyfssllm 173 17 for for IN work_av4lzmkbbzda3hgvpstyfssllm 173 18 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 173 19 by by IN work_av4lzmkbbzda3hgvpstyfssllm 173 20 direct direct JJ work_av4lzmkbbzda3hgvpstyfssllm 173 21 sequencing sequencing NN work_av4lzmkbbzda3hgvpstyfssllm 173 22 of of IN work_av4lzmkbbzda3hgvpstyfssllm 173 23 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 173 24 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 173 25 amplified amplify VBN work_av4lzmkbbzda3hgvpstyfssllm 173 26 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 173 27 DNA DNA NNP work_av4lzmkbbzda3hgvpstyfssllm 173 28 . . . work_av4lzmkbbzda3hgvpstyfssllm 174 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 174 2 iden- iden- VBP work_av4lzmkbbzda3hgvpstyfssllm 174 3 tified tifie VBD work_av4lzmkbbzda3hgvpstyfssllm 174 4 five five CD work_av4lzmkbbzda3hgvpstyfssllm 174 5 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 174 6 mutant mutant NN work_av4lzmkbbzda3hgvpstyfssllm 174 7 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 174 8 in in IN work_av4lzmkbbzda3hgvpstyfssllm 174 9 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 174 10 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 174 11 lines line NNS work_av4lzmkbbzda3hgvpstyfssllm 174 12 accounting account VBG work_av4lzmkbbzda3hgvpstyfssllm 174 13 for for IN work_av4lzmkbbzda3hgvpstyfssllm 174 14 ten ten CD work_av4lzmkbbzda3hgvpstyfssllm 174 15 of of IN work_av4lzmkbbzda3hgvpstyfssllm 174 16 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 174 17 possible possible JJ work_av4lzmkbbzda3hgvpstyfssllm 174 18 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 174 19 MCCA mcca NN work_av4lzmkbbzda3hgvpstyfssllm 174 20 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 174 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 174 22 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 174 23 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 174 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 174 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 175 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 175 2 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 175 3 include include VBP work_av4lzmkbbzda3hgvpstyfssllm 175 4 three three CD work_av4lzmkbbzda3hgvpstyfssllm 175 5 uncomplicated uncomplicated JJ work_av4lzmkbbzda3hgvpstyfssllm 175 6 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 175 7 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 175 8 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 175 9 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 175 10 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 175 11 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 175 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 175 13 one one CD work_av4lzmkbbzda3hgvpstyfssllm 175 14 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 175 15 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 175 16 that that IN work_av4lzmkbbzda3hgvpstyfssllm 175 17 alters alter NNS work_av4lzmkbbzda3hgvpstyfssllm 175 18 splicing splice VBG work_av4lzmkbbzda3hgvpstyfssllm 175 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 175 20 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 175 21 5a 5a NNP work_av4lzmkbbzda3hgvpstyfssllm 175 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 175 23 , , , work_av4lzmkbbzda3hgvpstyfssllm 175 24 and and CC work_av4lzmkbbzda3hgvpstyfssllm 175 25 one one CD work_av4lzmkbbzda3hgvpstyfssllm 175 26 1-bp 1-bp CD work_av4lzmkbbzda3hgvpstyfssllm 175 27 insertion insertion NN work_av4lzmkbbzda3hgvpstyfssllm 175 28 . . . work_av4lzmkbbzda3hgvpstyfssllm 176 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 176 2 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 176 3 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 176 4 lines line NNS work_av4lzmkbbzda3hgvpstyfssllm 176 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 176 6 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 176 7 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 176 8 nine nine CD work_av4lzmkbbzda3hgvpstyfssllm 176 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 176 10 mutant mutant NNP work_av4lzmkbbzda3hgvpstyfssllm 176 11 alle- alle- NNP work_av4lzmkbbzda3hgvpstyfssllm 176 12 les les NNP work_av4lzmkbbzda3hgvpstyfssllm 176 13 accounting account VBG work_av4lzmkbbzda3hgvpstyfssllm 176 14 for for IN work_av4lzmkbbzda3hgvpstyfssllm 176 15 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 176 16 of of IN work_av4lzmkbbzda3hgvpstyfssllm 176 17 16 16 CD work_av4lzmkbbzda3hgvpstyfssllm 176 18 possible possible JJ work_av4lzmkbbzda3hgvpstyfssllm 176 19 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 176 20 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 176 21 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 176 22 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 176 23 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 176 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 176 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 177 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 177 2 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 177 3 include include VBP work_av4lzmkbbzda3hgvpstyfssllm 177 4 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 177 5 uncomplicated uncomplicated JJ work_av4lzmkbbzda3hgvpstyfssllm 177 6 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 177 7 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 177 8 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 177 9 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 177 10 3b 3b NNP work_av4lzmkbbzda3hgvpstyfssllm 177 11 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 177 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 177 13 one one CD work_av4lzmkbbzda3hgvpstyfssllm 177 14 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 177 15 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 177 16 that that IN work_av4lzmkbbzda3hgvpstyfssllm 177 17 alters alter NNS work_av4lzmkbbzda3hgvpstyfssllm 177 18 splicing splice VBG work_av4lzmkbbzda3hgvpstyfssllm 177 19 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 177 20 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 177 21 5b 5b NN work_av4lzmkbbzda3hgvpstyfssllm 177 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 177 23 , , , work_av4lzmkbbzda3hgvpstyfssllm 177 24 one one CD work_av4lzmkbbzda3hgvpstyfssllm 177 25 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 177 26 site site NN work_av4lzmkbbzda3hgvpstyfssllm 177 27 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 177 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 177 29 and and CC work_av4lzmkbbzda3hgvpstyfssllm 177 30 one one CD work_av4lzmkbbzda3hgvpstyfssllm 177 31 1-bp 1-bp CD work_av4lzmkbbzda3hgvpstyfssllm 177 32 insertion insertion NN work_av4lzmkbbzda3hgvpstyfssllm 177 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 178 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 178 2 spite spite NN work_av4lzmkbbzda3hgvpstyfssllm 178 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 178 4 sequencing sequence VBG work_av4lzmkbbzda3hgvpstyfssllm 178 5 all all DT work_av4lzmkbbzda3hgvpstyfssllm 178 6 exons exon NNS work_av4lzmkbbzda3hgvpstyfssllm 178 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 178 8 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 178 9 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 178 10 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 178 11 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 178 12 with with IN work_av4lzmkbbzda3hgvpstyfssllm 178 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 178 14 exception exception NN work_av4lzmkbbzda3hgvpstyfssllm 178 15 of of IN work_av4lzmkbbzda3hgvpstyfssllm 178 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 178 17 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 178 18 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 178 19 a a DT work_av4lzmkbbzda3hgvpstyfssllm 178 20 low low JJ work_av4lzmkbbzda3hgvpstyfssllm 178 21 frequency frequency NN work_av4lzmkbbzda3hgvpstyfssllm 178 22 in in IN work_av4lzmkbbzda3hgvpstyfssllm 178 23 this this DT work_av4lzmkbbzda3hgvpstyfssllm 178 24 population population NN work_av4lzmkbbzda3hgvpstyfssllm 178 25 . . . work_av4lzmkbbzda3hgvpstyfssllm 179 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 179 2 did do VBD work_av4lzmkbbzda3hgvpstyfssllm 179 3 not not RB work_av4lzmkbbzda3hgvpstyfssllm 179 4 screen screen VB work_av4lzmkbbzda3hgvpstyfssllm 179 5 for for IN work_av4lzmkbbzda3hgvpstyfssllm 179 6 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 179 7 for for IN work_av4lzmkbbzda3hgvpstyfssllm 179 8 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 179 9 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 179 10 did do VBD work_av4lzmkbbzda3hgvpstyfssllm 179 11 not not RB work_av4lzmkbbzda3hgvpstyfssllm 179 12 have have VB work_av4lzmkbbzda3hgvpstyfssllm 179 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 179 14 appropriate appropriate JJ work_av4lzmkbbzda3hgvpstyfssllm 179 15 control control NN work_av4lzmkbbzda3hgvpstyfssllm 179 16 population population NN work_av4lzmkbbzda3hgvpstyfssllm 179 17 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 179 18 Vietnamese Vietnamese NNP work_av4lzmkbbzda3hgvpstyfssllm 179 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 179 20 MCCB- MCCB- NNP work_av4lzmkbbzda3hgvpstyfssllm 179 21 R155Q R155Q NNP work_av4lzmkbbzda3hgvpstyfssllm 179 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 179 23 -P310R -p310r WP work_av4lzmkbbzda3hgvpstyfssllm 179 24 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 179 25 Turkish Turkish NNP work_av4lzmkbbzda3hgvpstyfssllm 179 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 179 27 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 179 28 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 179 29 S173L S173L NNP work_av4lzmkbbzda3hgvpstyfssllm 179 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 179 31 -V339 -V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 179 32 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 179 33 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 179 34 . . . work_av4lzmkbbzda3hgvpstyfssllm 180 1 Discussion Discussion NNP work_av4lzmkbbzda3hgvpstyfssllm 180 2 Using use VBG work_av4lzmkbbzda3hgvpstyfssllm 180 3 a a DT work_av4lzmkbbzda3hgvpstyfssllm 180 4 combination combination NN work_av4lzmkbbzda3hgvpstyfssllm 180 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 180 6 homology homology NN work_av4lzmkbbzda3hgvpstyfssllm 180 7 probing probing NN work_av4lzmkbbzda3hgvpstyfssllm 180 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 180 9 mass mass JJ work_av4lzmkbbzda3hgvpstyfssllm 180 10 spectrometry spectrometry NN work_av4lzmkbbzda3hgvpstyfssllm 180 11 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 180 12 cloned clone VBD work_av4lzmkbbzda3hgvpstyfssllm 180 13 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 180 14 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 180 15 and and CC work_av4lzmkbbzda3hgvpstyfssllm 180 16 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 180 17 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 180 18 length length NN work_av4lzmkbbzda3hgvpstyfssllm 180 19 cDNAs cdna NNS work_av4lzmkbbzda3hgvpstyfssllm 180 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 181 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 181 2 conceptual conceptual JJ work_av4lzmkbbzda3hgvpstyfssllm 181 3 translation translation NN work_av4lzmkbbzda3hgvpstyfssllm 181 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 181 5 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 181 6 shows show VBZ work_av4lzmkbbzda3hgvpstyfssllm 181 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 181 8 expected expect VBN work_av4lzmkbbzda3hgvpstyfssllm 181 9 NH2-terminal nh2-terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 181 10 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 181 11 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 181 12 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 181 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 181 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 181 15 COOH COOH NNP work_av4lzmkbbzda3hgvpstyfssllm 181 16 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 181 17 terminal terminal NN work_av4lzmkbbzda3hgvpstyfssllm 181 18 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 181 19 carboxyl carboxyl NN work_av4lzmkbbzda3hgvpstyfssllm 181 20 carrier carrier NN work_av4lzmkbbzda3hgvpstyfssllm 181 21 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 181 22 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 181 23 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 181 24 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 181 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 181 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 181 27 separated separate VBN work_av4lzmkbbzda3hgvpstyfssllm 181 28 by by IN work_av4lzmkbbzda3hgvpstyfssllm 181 29 a a DT work_av4lzmkbbzda3hgvpstyfssllm 181 30 less less RBR work_av4lzmkbbzda3hgvpstyfssllm 181 31 conserved conserved JJ work_av4lzmkbbzda3hgvpstyfssllm 181 32 “ " `` work_av4lzmkbbzda3hgvpstyfssllm 181 33 hinge hinge NN work_av4lzmkbbzda3hgvpstyfssllm 181 34 ” " '' work_av4lzmkbbzda3hgvpstyfssllm 181 35 region region NN work_av4lzmkbbzda3hgvpstyfssllm 181 36 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 181 37 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 181 38 , , , work_av4lzmkbbzda3hgvpstyfssllm 181 39 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 181 40 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 181 41 . . . work_av4lzmkbbzda3hgvpstyfssllm 182 1 Presumably presumably RB work_av4lzmkbbzda3hgvpstyfssllm 182 2 because because IN work_av4lzmkbbzda3hgvpstyfssllm 182 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 182 4 differ- differ- JJ work_av4lzmkbbzda3hgvpstyfssllm 182 5 ences ence NNS work_av4lzmkbbzda3hgvpstyfssllm 182 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 182 7 substrate substrate JJ work_av4lzmkbbzda3hgvpstyfssllm 182 8 specificities specificity NNS work_av4lzmkbbzda3hgvpstyfssllm 182 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 182 10 carboxyltransferase carboxyltransferase NN work_av4lzmkbbzda3hgvpstyfssllm 182 11 domains domain NNS work_av4lzmkbbzda3hgvpstyfssllm 182 12 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 182 13 less less RBR work_av4lzmkbbzda3hgvpstyfssllm 182 14 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 182 15 among among IN work_av4lzmkbbzda3hgvpstyfssllm 182 16 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 182 17 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 182 18 dependent dependent JJ work_av4lzmkbbzda3hgvpstyfssllm 182 19 carboxylases carboxylase NNS work_av4lzmkbbzda3hgvpstyfssllm 182 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 183 1 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 183 2 catalyzes catalyze VBZ work_av4lzmkbbzda3hgvpstyfssllm 183 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 183 4 carboxylation carboxylation NN work_av4lzmkbbzda3hgvpstyfssllm 183 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 183 6 methylcrotonyl methylcrotonyl NNP work_av4lzmkbbzda3hgvpstyfssllm 183 7 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 183 8 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 183 9 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 183 10 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 183 11 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 183 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 184 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 184 2 acceptor acceptor NN work_av4lzmkbbzda3hgvpstyfssllm 184 3 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 184 4 site site NN work_av4lzmkbbzda3hgvpstyfssllm 184 5 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 184 6 thought think VBN work_av4lzmkbbzda3hgvpstyfssllm 184 7 to to TO work_av4lzmkbbzda3hgvpstyfssllm 184 8 be be VB work_av4lzmkbbzda3hgvpstyfssllm 184 9 on on IN work_av4lzmkbbzda3hgvpstyfssllm 184 10 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 184 11 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 184 12 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 184 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 184 14 39 39 CD work_av4lzmkbbzda3hgvpstyfssllm 184 15 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 184 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 185 1 Consistent consistent JJ work_av4lzmkbbzda3hgvpstyfssllm 185 2 with with IN work_av4lzmkbbzda3hgvpstyfssllm 185 3 this this DT work_av4lzmkbbzda3hgvpstyfssllm 185 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 185 5 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 185 6 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 185 7 shares share VBZ work_av4lzmkbbzda3hgvpstyfssllm 185 8 high high JJ work_av4lzmkbbzda3hgvpstyfssllm 185 9 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 185 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 185 11 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 185 12 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 185 13 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 185 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 185 15 60 60 CD work_av4lzmkbbzda3hgvpstyfssllm 185 16 % % NN work_av4lzmkbbzda3hgvpstyfssllm 185 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 185 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 185 19 only only RB work_av4lzmkbbzda3hgvpstyfssllm 185 20 28 28 CD work_av4lzmkbbzda3hgvpstyfssllm 185 21 % % NN work_av4lzmkbbzda3hgvpstyfssllm 185 22 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 185 23 with with IN work_av4lzmkbbzda3hgvpstyfssllm 185 24 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 185 25 PCCβ PCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 185 26 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 185 27 13 13 CD work_av4lzmkbbzda3hgvpstyfssllm 185 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 185 29 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 185 30 supports support VBZ work_av4lzmkbbzda3hgvpstyfssllm 185 31 the the DT work_av4lzmkbbzda3hgvpstyfssllm 185 32 role role NN work_av4lzmkbbzda3hgvpstyfssllm 185 33 of of IN work_av4lzmkbbzda3hgvpstyfssllm 185 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 185 35 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 185 36 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 185 37 in in IN work_av4lzmkbbzda3hgvpstyfssllm 185 38 determin- determin- JJ work_av4lzmkbbzda3hgvpstyfssllm 185 39 ing ing JJ work_av4lzmkbbzda3hgvpstyfssllm 185 40 substrate substrate JJ work_av4lzmkbbzda3hgvpstyfssllm 185 41 specificity specificity NN work_av4lzmkbbzda3hgvpstyfssllm 185 42 of of IN work_av4lzmkbbzda3hgvpstyfssllm 185 43 these these DT work_av4lzmkbbzda3hgvpstyfssllm 185 44 enzymes enzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 185 45 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 185 46 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 185 47 3b 3b NN work_av4lzmkbbzda3hgvpstyfssllm 185 48 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 185 49 . . . work_av4lzmkbbzda3hgvpstyfssllm 186 1 Our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 186 2 series series NN work_av4lzmkbbzda3hgvpstyfssllm 186 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 186 4 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 186 5 MCCA- MCCA- NNP work_av4lzmkbbzda3hgvpstyfssllm 186 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 186 7 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 186 8 MCCB mccb NN work_av4lzmkbbzda3hgvpstyfssllm 186 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 186 10 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 186 11 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 186 12 flanking flank VBG work_av4lzmkbbzda3hgvpstyfssllm 186 13 intronic intronic JJ work_av4lzmkbbzda3hgvpstyfssllm 186 14 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 186 15 of of IN work_av4lzmkbbzda3hgvpstyfssllm 186 16 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 186 17 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 186 18 8) 8) CD work_av4lzmkbbzda3hgvpstyfssllm 186 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 186 20 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 186 21 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 186 22 not not RB work_av4lzmkbbzda3hgvpstyfssllm 186 23 able able JJ work_av4lzmkbbzda3hgvpstyfssllm 186 24 to to TO work_av4lzmkbbzda3hgvpstyfssllm 186 25 identify identify VB work_av4lzmkbbzda3hgvpstyfssllm 186 26 a a DT work_av4lzmkbbzda3hgvpstyfssllm 186 27 second second JJ work_av4lzmkbbzda3hgvpstyfssllm 186 28 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 186 29 in in IN work_av4lzmkbbzda3hgvpstyfssllm 186 30 two two CD work_av4lzmkbbzda3hgvpstyfssllm 186 31 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 186 32 and and CC work_av4lzmkbbzda3hgvpstyfssllm 186 33 four four CD work_av4lzmkbbzda3hgvpstyfssllm 186 34 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 186 35 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 186 36 . . . work_av4lzmkbbzda3hgvpstyfssllm 187 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 187 2 five five CD work_av4lzmkbbzda3hgvpstyfssllm 187 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 187 4 these these DT work_av4lzmkbbzda3hgvpstyfssllm 187 5 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 187 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 187 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 187 8 one one CD work_av4lzmkbbzda3hgvpstyfssllm 187 9 allele allele NNP work_av4lzmkbbzda3hgvpstyfssllm 187 10 identi- identi- NN work_av4lzmkbbzda3hgvpstyfssllm 187 11 fied fie VBN work_av4lzmkbbzda3hgvpstyfssllm 187 12 appeared appear VBD work_av4lzmkbbzda3hgvpstyfssllm 187 13 to to TO work_av4lzmkbbzda3hgvpstyfssllm 187 14 be be VB work_av4lzmkbbzda3hgvpstyfssllm 187 15 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 187 16 in in IN work_av4lzmkbbzda3hgvpstyfssllm 187 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 187 18 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 187 19 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 187 20 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 187 21 product product NN work_av4lzmkbbzda3hgvpstyfssllm 187 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 187 23 but but CC work_av4lzmkbbzda3hgvpstyfssllm 187 24 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 187 25 clearly clearly RB work_av4lzmkbbzda3hgvpstyfssllm 187 26 heterozygous heterozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 187 27 in in IN work_av4lzmkbbzda3hgvpstyfssllm 187 28 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 187 29 DNA dna NN work_av4lzmkbbzda3hgvpstyfssllm 187 30 , , , work_av4lzmkbbzda3hgvpstyfssllm 187 31 sug- sug- XX work_av4lzmkbbzda3hgvpstyfssllm 187 32 gesting geste VBG work_av4lzmkbbzda3hgvpstyfssllm 187 33 that that IN work_av4lzmkbbzda3hgvpstyfssllm 187 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 187 35 steady steady JJ work_av4lzmkbbzda3hgvpstyfssllm 187 36 level level NN work_av4lzmkbbzda3hgvpstyfssllm 187 37 of of IN work_av4lzmkbbzda3hgvpstyfssllm 187 38 mRNA mRNA NNS work_av4lzmkbbzda3hgvpstyfssllm 187 39 from from IN work_av4lzmkbbzda3hgvpstyfssllm 187 40 the the DT work_av4lzmkbbzda3hgvpstyfssllm 187 41 second second JJ work_av4lzmkbbzda3hgvpstyfssllm 187 42 allele allele NNP work_av4lzmkbbzda3hgvpstyfssllm 187 43 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 187 44 not not RB work_av4lzmkbbzda3hgvpstyfssllm 187 45 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 187 46 as as IN work_av4lzmkbbzda3hgvpstyfssllm 187 47 would would MD work_av4lzmkbbzda3hgvpstyfssllm 187 48 be be VB work_av4lzmkbbzda3hgvpstyfssllm 187 49 the the DT work_av4lzmkbbzda3hgvpstyfssllm 187 50 case case NN work_av4lzmkbbzda3hgvpstyfssllm 187 51 for for IN work_av4lzmkbbzda3hgvpstyfssllm 187 52 a a DT work_av4lzmkbbzda3hgvpstyfssllm 187 53 promoter promoter NN work_av4lzmkbbzda3hgvpstyfssllm 187 54 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 187 55 or or CC work_av4lzmkbbzda3hgvpstyfssllm 187 56 an an DT work_av4lzmkbbzda3hgvpstyfssllm 187 57 intra- intra- JJ work_av4lzmkbbzda3hgvpstyfssllm 187 58 genic genic JJ work_av4lzmkbbzda3hgvpstyfssllm 187 59 deletion deletion NN work_av4lzmkbbzda3hgvpstyfssllm 187 60 or or CC work_av4lzmkbbzda3hgvpstyfssllm 187 61 insertion insertion NN work_av4lzmkbbzda3hgvpstyfssllm 187 62 missed miss VBN work_av4lzmkbbzda3hgvpstyfssllm 187 63 by by IN work_av4lzmkbbzda3hgvpstyfssllm 187 64 genomic genomic JJ work_av4lzmkbbzda3hgvpstyfssllm 187 65 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 187 66 . . . work_av4lzmkbbzda3hgvpstyfssllm 188 1 These these DT work_av4lzmkbbzda3hgvpstyfssllm 188 2 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 188 3 strong- strong- VBP work_av4lzmkbbzda3hgvpstyfssllm 188 4 ly ly XX work_av4lzmkbbzda3hgvpstyfssllm 188 5 support support NN work_av4lzmkbbzda3hgvpstyfssllm 188 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 188 7 identification identification NN work_av4lzmkbbzda3hgvpstyfssllm 188 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 188 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 188 10 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 188 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 188 12 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 188 13 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 188 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 188 15 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 188 16 assignment assignment NN work_av4lzmkbbzda3hgvpstyfssllm 188 17 to to IN work_av4lzmkbbzda3hgvpstyfssllm 188 18 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 188 19 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 188 20 in in IN work_av4lzmkbbzda3hgvpstyfssllm 188 21 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 188 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 188 23 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 188 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 188 25 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 188 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 189 1 Expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 189 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 189 3 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 189 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 189 5 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 189 6 alleles allele VBZ work_av4lzmkbbzda3hgvpstyfssllm 189 7 As as IN work_av4lzmkbbzda3hgvpstyfssllm 189 8 a a DT work_av4lzmkbbzda3hgvpstyfssllm 189 9 final final JJ work_av4lzmkbbzda3hgvpstyfssllm 189 10 test test NN work_av4lzmkbbzda3hgvpstyfssllm 189 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 189 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 189 13 identity identity NN work_av4lzmkbbzda3hgvpstyfssllm 189 14 of of IN work_av4lzmkbbzda3hgvpstyfssllm 189 15 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 189 16 candidate candidate NN work_av4lzmkbbzda3hgvpstyfssllm 189 17 human human NN work_av4lzmkbbzda3hgvpstyfssllm 189 18 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 189 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 189 20 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 189 21 cDNAs cDNAs NNP work_av4lzmkbbzda3hgvpstyfssllm 189 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 189 23 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 189 24 subcloned subclone VBD work_av4lzmkbbzda3hgvpstyfssllm 189 25 them -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 189 26 into into IN work_av4lzmkbbzda3hgvpstyfssllm 189 27 a a DT work_av4lzmkbbzda3hgvpstyfssllm 189 28 mammalian mammalian JJ work_av4lzmkbbzda3hgvpstyfssllm 189 29 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 189 30 vector vector NN work_av4lzmkbbzda3hgvpstyfssllm 189 31 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 189 32 pTracer pTracer NNP work_av4lzmkbbzda3hgvpstyfssllm 189 33 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 189 34 CMV2 CMV2 NNP work_av4lzmkbbzda3hgvpstyfssllm 189 35 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 189 36 , , , work_av4lzmkbbzda3hgvpstyfssllm 189 37 electroporated electroporate VBD work_av4lzmkbbzda3hgvpstyfssllm 189 38 the the DT work_av4lzmkbbzda3hgvpstyfssllm 189 39 recombinant recombinant JJ work_av4lzmkbbzda3hgvpstyfssllm 189 40 constructs construct NNS work_av4lzmkbbzda3hgvpstyfssllm 189 41 into into IN work_av4lzmkbbzda3hgvpstyfssllm 189 42 a a DT work_av4lzmkbbzda3hgvpstyfssllm 189 43 SV40 SV40 NNP work_av4lzmkbbzda3hgvpstyfssllm 189 44 T T NNP work_av4lzmkbbzda3hgvpstyfssllm 189 45 transformed transform VBN work_av4lzmkbbzda3hgvpstyfssllm 189 46 reference reference NN work_av4lzmkbbzda3hgvpstyfssllm 189 47 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 189 48 or or CC work_av4lzmkbbzda3hgvpstyfssllm 189 49 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 189 50 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 189 51 line line NN work_av4lzmkbbzda3hgvpstyfssllm 189 52 , , , work_av4lzmkbbzda3hgvpstyfssllm 189 53 and and CC work_av4lzmkbbzda3hgvpstyfssllm 189 54 measured measure VBN work_av4lzmkbbzda3hgvpstyfssllm 189 55 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 189 56 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 189 57 72 72 CD work_av4lzmkbbzda3hgvpstyfssllm 189 58 hours hour NNS work_av4lzmkbbzda3hgvpstyfssllm 189 59 later later RB work_av4lzmkbbzda3hgvpstyfssllm 189 60 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 189 61 27 27 CD work_av4lzmkbbzda3hgvpstyfssllm 189 62 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 189 63 . . . work_av4lzmkbbzda3hgvpstyfssllm 190 1 As as IN work_av4lzmkbbzda3hgvpstyfssllm 190 2 a a DT work_av4lzmkbbzda3hgvpstyfssllm 190 3 ref- ref- JJ work_av4lzmkbbzda3hgvpstyfssllm 190 4 erence erence NN work_av4lzmkbbzda3hgvpstyfssllm 190 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 190 6 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 190 7 also also RB work_av4lzmkbbzda3hgvpstyfssllm 190 8 measured measure VBD work_av4lzmkbbzda3hgvpstyfssllm 190 9 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 190 10 activ- activ- JJ work_av4lzmkbbzda3hgvpstyfssllm 190 11 ity ity NN work_av4lzmkbbzda3hgvpstyfssllm 190 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 190 13 27 27 CD work_av4lzmkbbzda3hgvpstyfssllm 190 14 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 190 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 191 1 Wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 191 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 191 3 type type NN work_av4lzmkbbzda3hgvpstyfssllm 191 4 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 191 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 191 6 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 191 7 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 191 8 restored restore VBD work_av4lzmkbbzda3hgvpstyfssllm 191 9 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 191 10 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 191 11 to to IN work_av4lzmkbbzda3hgvpstyfssllm 191 12 43 43 CD work_av4lzmkbbzda3hgvpstyfssllm 191 13 % % NN work_av4lzmkbbzda3hgvpstyfssllm 191 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 191 15 53 53 CD work_av4lzmkbbzda3hgvpstyfssllm 191 16 % % NN work_av4lzmkbbzda3hgvpstyfssllm 191 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 191 18 untransfected untransfected JJ work_av4lzmkbbzda3hgvpstyfssllm 191 19 control control NN work_av4lzmkbbzda3hgvpstyfssllm 191 20 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 191 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 191 22 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 191 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 191 24 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 191 25 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 191 26 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 191 27 . . . work_av4lzmkbbzda3hgvpstyfssllm 192 1 Transfection transfection NN work_av4lzmkbbzda3hgvpstyfssllm 192 2 efficiency efficiency NN work_av4lzmkbbzda3hgvpstyfssllm 192 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 192 4 assessed assess VBN work_av4lzmkbbzda3hgvpstyfssllm 192 5 by by IN work_av4lzmkbbzda3hgvpstyfssllm 192 6 scoring score VBG work_av4lzmkbbzda3hgvpstyfssllm 192 7 a a DT work_av4lzmkbbzda3hgvpstyfssllm 192 8 subset subset NN work_av4lzmkbbzda3hgvpstyfssllm 192 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 192 10 cells cell NNS work_av4lzmkbbzda3hgvpstyfssllm 192 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 192 12 each each DT work_av4lzmkbbzda3hgvpstyfssllm 192 13 transfection transfection NN work_av4lzmkbbzda3hgvpstyfssllm 192 14 for for IN work_av4lzmkbbzda3hgvpstyfssllm 192 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 192 16 presence presence NN work_av4lzmkbbzda3hgvpstyfssllm 192 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 192 18 the the DT work_av4lzmkbbzda3hgvpstyfssllm 192 19 coexpressed coexpresse VBN work_av4lzmkbbzda3hgvpstyfssllm 192 20 GFP GFP NNP work_av4lzmkbbzda3hgvpstyfssllm 192 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 192 22 ranged range VBD work_av4lzmkbbzda3hgvpstyfssllm 192 23 from from IN work_av4lzmkbbzda3hgvpstyfssllm 192 24 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 192 25 to to TO work_av4lzmkbbzda3hgvpstyfssllm 192 26 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 192 27 % % NN work_av4lzmkbbzda3hgvpstyfssllm 192 28 in in IN work_av4lzmkbbzda3hgvpstyfssllm 192 29 these these DT work_av4lzmkbbzda3hgvpstyfssllm 192 30 experiments experiment NNS work_av4lzmkbbzda3hgvpstyfssllm 192 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 193 1 Similarly similarly RB work_av4lzmkbbzda3hgvpstyfssllm 193 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 193 3 to to TO work_av4lzmkbbzda3hgvpstyfssllm 193 4 test test VB work_av4lzmkbbzda3hgvpstyfssllm 193 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 193 6 functional functional JJ work_av4lzmkbbzda3hgvpstyfssllm 193 7 consequences consequence NNS work_av4lzmkbbzda3hgvpstyfssllm 193 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 193 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 193 10 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 193 11 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 193 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 193 13 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 193 14 expressed express VBD work_av4lzmkbbzda3hgvpstyfssllm 193 15 three three CD work_av4lzmkbbzda3hgvpstyfssllm 193 16 MCCA MCCA NNS work_av4lzmkbbzda3hgvpstyfssllm 193 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 193 18 six six CD work_av4lzmkbbzda3hgvpstyfssllm 193 19 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 193 20 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 193 21 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 193 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 194 1 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 194 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 194 3 R193C R193C NNP work_av4lzmkbbzda3hgvpstyfssllm 194 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 194 5 -V339 -V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 194 6 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 194 7 had have VBD work_av4lzmkbbzda3hgvpstyfssllm 194 8 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 194 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 194 10 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 194 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 194 12 7 7 CD work_av4lzmkbbzda3hgvpstyfssllm 194 13 pmol pmol NN work_av4lzmkbbzda3hgvpstyfssllm 194 14 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 194 15 min min NNP work_av4lzmkbbzda3hgvpstyfssllm 194 16 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 194 17 mg mg NNP work_av4lzmkbbzda3hgvpstyfssllm 194 18 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 194 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 194 20 respectively respectively RB work_av4lzmkbbzda3hgvpstyfssllm 194 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 194 22 or or CC work_av4lzmkbbzda3hgvpstyfssllm 194 23 about about RB work_av4lzmkbbzda3hgvpstyfssllm 194 24 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 194 25 % % NN work_av4lzmkbbzda3hgvpstyfssllm 194 26 of of IN work_av4lzmkbbzda3hgvpstyfssllm 194 27 the the DT work_av4lzmkbbzda3hgvpstyfssllm 194 28 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 194 29 produced produce VBN work_av4lzmkbbzda3hgvpstyfssllm 194 30 by by IN work_av4lzmkbbzda3hgvpstyfssllm 194 31 the the DT work_av4lzmkbbzda3hgvpstyfssllm 194 32 wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 194 33 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 194 34 type type NN work_av4lzmkbbzda3hgvpstyfssllm 194 35 allele allele NNS work_av4lzmkbbzda3hgvpstyfssllm 194 36 , , , work_av4lzmkbbzda3hgvpstyfssllm 194 37 whereas whereas IN work_av4lzmkbbzda3hgvpstyfssllm 194 38 the the DT work_av4lzmkbbzda3hgvpstyfssllm 194 39 remaining remain VBG work_av4lzmkbbzda3hgvpstyfssllm 194 40 four four CD work_av4lzmkbbzda3hgvpstyfssllm 194 41 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 194 42 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 194 43 and and CC work_av4lzmkbbzda3hgvpstyfssllm 194 44 the the DT work_av4lzmkbbzda3hgvpstyfssllm 194 45 three three CD work_av4lzmkbbzda3hgvpstyfssllm 194 46 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 194 47 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 194 48 produced produce VBD work_av4lzmkbbzda3hgvpstyfssllm 194 49 no no DT work_av4lzmkbbzda3hgvpstyfssllm 194 50 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 194 51 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 194 52 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 194 53 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 194 54 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 194 55 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 194 56 . . . work_av4lzmkbbzda3hgvpstyfssllm 195 1 These these DT work_av4lzmkbbzda3hgvpstyfssllm 195 2 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 195 3 confirm confirm VBP work_av4lzmkbbzda3hgvpstyfssllm 195 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 195 5 deleterious deleterious JJ work_av4lzmkbbzda3hgvpstyfssllm 195 6 func- func- JJ work_av4lzmkbbzda3hgvpstyfssllm 195 7 tional tional JJ work_av4lzmkbbzda3hgvpstyfssllm 195 8 consequences consequence NNS work_av4lzmkbbzda3hgvpstyfssllm 195 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 195 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 195 11 tested test VBN work_av4lzmkbbzda3hgvpstyfssllm 195 12 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 195 13 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 195 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 196 1 Population population NN work_av4lzmkbbzda3hgvpstyfssllm 196 2 frequency frequency NN work_av4lzmkbbzda3hgvpstyfssllm 196 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 196 4 selected select VBN work_av4lzmkbbzda3hgvpstyfssllm 196 5 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 196 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 196 7 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 196 8 alleles allele VBZ work_av4lzmkbbzda3hgvpstyfssllm 196 9 Additionally additionally RB work_av4lzmkbbzda3hgvpstyfssllm 196 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 196 11 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 196 12 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 196 13 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 196 14 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 196 15 specific specific JJ work_av4lzmkbbzda3hgvpstyfssllm 196 16 oligonucleotide oligonucleotide JJ work_av4lzmkbbzda3hgvpstyfssllm 196 17 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 196 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 196 19 34 34 CD work_av4lzmkbbzda3hgvpstyfssllm 196 20 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 196 21 to to TO work_av4lzmkbbzda3hgvpstyfssllm 196 22 survey survey VB work_av4lzmkbbzda3hgvpstyfssllm 196 23 a a DT work_av4lzmkbbzda3hgvpstyfssllm 196 24 North north JJ work_av4lzmkbbzda3hgvpstyfssllm 196 25 American american JJ work_av4lzmkbbzda3hgvpstyfssllm 196 26 control control NN work_av4lzmkbbzda3hgvpstyfssllm 196 27 popu- popu- NNP work_av4lzmkbbzda3hgvpstyfssllm 196 28 lation lation NN work_av4lzmkbbzda3hgvpstyfssllm 196 29 of of IN work_av4lzmkbbzda3hgvpstyfssllm 196 30 66 66 CD work_av4lzmkbbzda3hgvpstyfssllm 196 31 individuals individual NNS work_av4lzmkbbzda3hgvpstyfssllm 196 32 for for IN work_av4lzmkbbzda3hgvpstyfssllm 196 33 three three CD work_av4lzmkbbzda3hgvpstyfssllm 196 34 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 196 35 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 196 36 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 196 37 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 196 38 , , , work_av4lzmkbbzda3hgvpstyfssllm 196 39 A289V A289V NNP work_av4lzmkbbzda3hgvpstyfssllm 196 40 , , , work_av4lzmkbbzda3hgvpstyfssllm 196 41 and and CC work_av4lzmkbbzda3hgvpstyfssllm 196 42 L437P L437P NNP work_av4lzmkbbzda3hgvpstyfssllm 196 43 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 196 44 and and CC work_av4lzmkbbzda3hgvpstyfssllm 196 45 two two CD work_av4lzmkbbzda3hgvpstyfssllm 196 46 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 196 47 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 196 48 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 196 49 E99Q E99Q NNP work_av4lzmkbbzda3hgvpstyfssllm 196 50 and and CC work_av4lzmkbbzda3hgvpstyfssllm 196 51 R193C r193c SYM work_av4lzmkbbzda3hgvpstyfssllm 196 52 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 196 53 . . . work_av4lzmkbbzda3hgvpstyfssllm 197 1 Aside aside RB work_av4lzmkbbzda3hgvpstyfssllm 197 2 from from IN work_av4lzmkbbzda3hgvpstyfssllm 197 3 one one CD work_av4lzmkbbzda3hgvpstyfssllm 197 4 individual individual NN work_av4lzmkbbzda3hgvpstyfssllm 197 5 heterozygous heterozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 197 6 for for IN work_av4lzmkbbzda3hgvpstyfssllm 197 7 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 197 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 197 9 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 197 10 did do VBD work_av4lzmkbbzda3hgvpstyfssllm 197 11 not not RB work_av4lzmkbbzda3hgvpstyfssllm 197 12 identify identify VB work_av4lzmkbbzda3hgvpstyfssllm 197 13 any any DT work_av4lzmkbbzda3hgvpstyfssllm 197 14 of of IN work_av4lzmkbbzda3hgvpstyfssllm 197 15 these these DT work_av4lzmkbbzda3hgvpstyfssllm 197 16 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 197 17 in in IN work_av4lzmkbbzda3hgvpstyfssllm 197 18 this this DT work_av4lzmkbbzda3hgvpstyfssllm 197 19 collection collection NN work_av4lzmkbbzda3hgvpstyfssllm 197 20 of of IN work_av4lzmkbbzda3hgvpstyfssllm 197 21 132 132 CD work_av4lzmkbbzda3hgvpstyfssllm 197 22 control control NN work_av4lzmkbbzda3hgvpstyfssllm 197 23 chromosomes chromosome NNS work_av4lzmkbbzda3hgvpstyfssllm 197 24 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 197 25 data datum NNS work_av4lzmkbbzda3hgvpstyfssllm 197 26 not not RB work_av4lzmkbbzda3hgvpstyfssllm 197 27 shown show VBN work_av4lzmkbbzda3hgvpstyfssllm 197 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 197 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 198 1 These these DT work_av4lzmkbbzda3hgvpstyfssllm 198 2 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 198 3 indicate indicate VBP work_av4lzmkbbzda3hgvpstyfssllm 198 4 that that IN work_av4lzmkbbzda3hgvpstyfssllm 198 5 each each DT work_av4lzmkbbzda3hgvpstyfssllm 198 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 198 7 these these DT work_av4lzmkbbzda3hgvpstyfssllm 198 8 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 198 9 The the DT work_av4lzmkbbzda3hgvpstyfssllm 198 10 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 198 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 198 12 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 198 13 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 198 14 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 198 15 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 198 16 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 198 17 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 198 18 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 198 19 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 198 20 | | CD work_av4lzmkbbzda3hgvpstyfssllm 198 21 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 198 22 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 198 23 501 501 CD work_av4lzmkbbzda3hgvpstyfssllm 198 24 Figure figure NN work_av4lzmkbbzda3hgvpstyfssllm 198 25 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 198 26 MCCA MCCA NNS work_av4lzmkbbzda3hgvpstyfssllm 198 27 and and CC work_av4lzmkbbzda3hgvpstyfssllm 198 28 B b NN work_av4lzmkbbzda3hgvpstyfssllm 198 29 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 198 30 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 198 31 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 198 32 alter alter VBP work_av4lzmkbbzda3hgvpstyfssllm 198 33 splicing splicing NN work_av4lzmkbbzda3hgvpstyfssllm 198 34 . . . work_av4lzmkbbzda3hgvpstyfssllm 199 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 199 2 a a LS work_av4lzmkbbzda3hgvpstyfssllm 199 3 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 199 4 MCCA mcca NN work_av4lzmkbbzda3hgvpstyfssllm 199 5 D532H. d532h. NN work_av4lzmkbbzda3hgvpstyfssllm 200 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 200 2 1594G→C 1594g→c CD work_av4lzmkbbzda3hgvpstyfssllm 200 3 trans- trans- JJ work_av4lzmkbbzda3hgvpstyfssllm 200 4 version version NN work_av4lzmkbbzda3hgvpstyfssllm 200 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 200 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 200 7 last last JJ work_av4lzmkbbzda3hgvpstyfssllm 200 8 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 200 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 200 10 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 200 11 13 13 CD work_av4lzmkbbzda3hgvpstyfssllm 200 12 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 200 13 in in IN work_av4lzmkbbzda3hgvpstyfssllm 200 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 200 15 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 200 16 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 200 17 D532H. D532H. . work_av4lzmkbbzda3hgvpstyfssllm 201 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 201 2 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 201 3 base base NN work_av4lzmkbbzda3hgvpstyfssllm 201 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 201 5 an an DT work_av4lzmkbbzda3hgvpstyfssllm 201 6 exon exon NN work_av4lzmkbbzda3hgvpstyfssllm 201 7 also also RB work_av4lzmkbbzda3hgvpstyfssllm 201 8 contributes contribute VBZ work_av4lzmkbbzda3hgvpstyfssllm 201 9 to to TO work_av4lzmkbbzda3hgvpstyfssllm 201 10 donor donor NN work_av4lzmkbbzda3hgvpstyfssllm 201 11 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 201 12 site site NN work_av4lzmkbbzda3hgvpstyfssllm 201 13 recognition recognition NN work_av4lzmkbbzda3hgvpstyfssllm 201 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 201 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 201 16 as as IN work_av4lzmkbbzda3hgvpstyfssllm 201 17 shown show VBN work_av4lzmkbbzda3hgvpstyfssllm 201 18 in in IN work_av4lzmkbbzda3hgvpstyfssllm 201 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 201 20 lower low JJR work_av4lzmkbbzda3hgvpstyfssllm 201 21 panel panel NN work_av4lzmkbbzda3hgvpstyfssllm 201 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 201 23 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 201 24 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 201 25 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 201 26 of of IN work_av4lzmkbbzda3hgvpstyfssllm 201 27 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 201 28 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 201 29 in in IN work_av4lzmkbbzda3hgvpstyfssllm 201 30 this this DT work_av4lzmkbbzda3hgvpstyfssllm 201 31 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 201 32 with with IN work_av4lzmkbbzda3hgvpstyfssllm 201 33 primers primer NNS work_av4lzmkbbzda3hgvpstyfssllm 201 34 corresponding correspond VBG work_av4lzmkbbzda3hgvpstyfssllm 201 35 to to IN work_av4lzmkbbzda3hgvpstyfssllm 201 36 the the DT work_av4lzmkbbzda3hgvpstyfssllm 201 37 5′ 5′ CD work_av4lzmkbbzda3hgvpstyfssllm 201 38 and and CC work_av4lzmkbbzda3hgvpstyfssllm 201 39 3′ 3′ CD work_av4lzmkbbzda3hgvpstyfssllm 201 40 UTR UTR NNP work_av4lzmkbbzda3hgvpstyfssllm 201 41 resulted result VBD work_av4lzmkbbzda3hgvpstyfssllm 201 42 in in IN work_av4lzmkbbzda3hgvpstyfssllm 201 43 a a DT work_av4lzmkbbzda3hgvpstyfssllm 201 44 product product NN work_av4lzmkbbzda3hgvpstyfssllm 201 45 smaller small JJR work_av4lzmkbbzda3hgvpstyfssllm 201 46 than than IN work_av4lzmkbbzda3hgvpstyfssllm 201 47 in in IN work_av4lzmkbbzda3hgvpstyfssllm 201 48 wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 201 49 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 201 50 type type NN work_av4lzmkbbzda3hgvpstyfssllm 201 51 . . . work_av4lzmkbbzda3hgvpstyfssllm 202 1 Sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 202 2 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 202 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 202 4 this this DT work_av4lzmkbbzda3hgvpstyfssllm 202 5 product product NN work_av4lzmkbbzda3hgvpstyfssllm 202 6 showed show VBD work_av4lzmkbbzda3hgvpstyfssllm 202 7 that that IN work_av4lzmkbbzda3hgvpstyfssllm 202 8 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 202 9 13 13 CD work_av4lzmkbbzda3hgvpstyfssllm 202 10 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 202 11 217 217 CD work_av4lzmkbbzda3hgvpstyfssllm 202 12 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 202 13 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 202 14 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 202 15 skipped skip VBN work_av4lzmkbbzda3hgvpstyfssllm 202 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 202 17 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 202 18 shifts shift VBZ work_av4lzmkbbzda3hgvpstyfssllm 202 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 202 20 reading reading NN work_av4lzmkbbzda3hgvpstyfssllm 202 21 frame frame NN work_av4lzmkbbzda3hgvpstyfssllm 202 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 203 1 Thus thus RB work_av4lzmkbbzda3hgvpstyfssllm 203 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 203 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 203 4 deleterious deleterious JJ work_av4lzmkbbzda3hgvpstyfssllm 203 5 consequences consequence NNS work_av4lzmkbbzda3hgvpstyfssllm 203 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 203 7 this this DT work_av4lzmkbbzda3hgvpstyfssllm 203 8 mis- mis- NN work_av4lzmkbbzda3hgvpstyfssllm 203 9 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 203 10 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 203 11 appear appear VBP work_av4lzmkbbzda3hgvpstyfssllm 203 12 to to TO work_av4lzmkbbzda3hgvpstyfssllm 203 13 be be VB work_av4lzmkbbzda3hgvpstyfssllm 203 14 entirely entirely RB work_av4lzmkbbzda3hgvpstyfssllm 203 15 due due JJ work_av4lzmkbbzda3hgvpstyfssllm 203 16 to to IN work_av4lzmkbbzda3hgvpstyfssllm 203 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 203 18 splicing splicing NN work_av4lzmkbbzda3hgvpstyfssllm 203 19 defect defect NN work_av4lzmkbbzda3hgvpstyfssllm 203 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 204 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 204 2 b b NN work_av4lzmkbbzda3hgvpstyfssllm 204 3 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 204 4 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 204 5 I437V. I437V. NNS work_av4lzmkbbzda3hgvpstyfssllm 205 1 As as IN work_av4lzmkbbzda3hgvpstyfssllm 205 2 shown show VBN work_av4lzmkbbzda3hgvpstyfssllm 205 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 205 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 205 5 upper upper JJ work_av4lzmkbbzda3hgvpstyfssllm 205 6 panel panel NN work_av4lzmkbbzda3hgvpstyfssllm 205 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 205 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 205 9 1309A→G 1309a→g CD work_av4lzmkbbzda3hgvpstyfssllm 205 10 transition transition NN work_av4lzmkbbzda3hgvpstyfssllm 205 11 in in IN work_av4lzmkbbzda3hgvpstyfssllm 205 12 exon exon JJ work_av4lzmkbbzda3hgvpstyfssllm 205 13 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 205 14 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 205 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 205 16 the the DT work_av4lzmkbbzda3hgvpstyfssllm 205 17 replacement replacement NN work_av4lzmkbbzda3hgvpstyfssllm 205 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 205 19 isoleucine isoleucine NN work_av4lzmkbbzda3hgvpstyfssllm 205 20 by by IN work_av4lzmkbbzda3hgvpstyfssllm 205 21 valine valine NN work_av4lzmkbbzda3hgvpstyfssllm 205 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 205 23 a a DT work_av4lzmkbbzda3hgvpstyfssllm 205 24 conservative conservative JJ work_av4lzmkbbzda3hgvpstyfssllm 205 25 change change NN work_av4lzmkbbzda3hgvpstyfssllm 205 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 206 1 However however RB work_av4lzmkbbzda3hgvpstyfssllm 206 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 206 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 206 4 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 206 5 also also RB work_av4lzmkbbzda3hgvpstyfssllm 206 6 activates activate VBZ work_av4lzmkbbzda3hgvpstyfssllm 206 7 a a DT work_av4lzmkbbzda3hgvpstyfssllm 206 8 cryptic cryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 206 9 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 206 10 donor donor NN work_av4lzmkbbzda3hgvpstyfssllm 206 11 . . . work_av4lzmkbbzda3hgvpstyfssllm 207 1 Use use NN work_av4lzmkbbzda3hgvpstyfssllm 207 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 207 3 this this DT work_av4lzmkbbzda3hgvpstyfssllm 207 4 new new JJ work_av4lzmkbbzda3hgvpstyfssllm 207 5 donor donor NN work_av4lzmkbbzda3hgvpstyfssllm 207 6 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 207 7 site site NN work_av4lzmkbbzda3hgvpstyfssllm 207 8 deletes delete VBZ work_av4lzmkbbzda3hgvpstyfssllm 207 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 207 10 last last JJ work_av4lzmkbbzda3hgvpstyfssllm 207 11 64 64 CD work_av4lzmkbbzda3hgvpstyfssllm 207 12 bp bp NN work_av4lzmkbbzda3hgvpstyfssllm 207 13 of of IN work_av4lzmkbbzda3hgvpstyfssllm 207 14 exon exon NNP work_av4lzmkbbzda3hgvpstyfssllm 207 15 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 207 16 from from IN work_av4lzmkbbzda3hgvpstyfssllm 207 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 207 18 mature mature JJ work_av4lzmkbbzda3hgvpstyfssllm 207 19 transcript transcript NN work_av4lzmkbbzda3hgvpstyfssllm 207 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 208 1 As as IN work_av4lzmkbbzda3hgvpstyfssllm 208 2 shown show VBN work_av4lzmkbbzda3hgvpstyfssllm 208 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 208 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 208 5 lower low JJR work_av4lzmkbbzda3hgvpstyfssllm 208 6 panel panel NN work_av4lzmkbbzda3hgvpstyfssllm 208 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 208 8 direct direct JJ work_av4lzmkbbzda3hgvpstyfssllm 208 9 sequencing sequencing NN work_av4lzmkbbzda3hgvpstyfssllm 208 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 208 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 208 12 RT RT NNP work_av4lzmkbbzda3hgvpstyfssllm 208 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 208 14 PCR PCR NNP work_av4lzmkbbzda3hgvpstyfssllm 208 15 product product NN work_av4lzmkbbzda3hgvpstyfssllm 208 16 shows show VBZ work_av4lzmkbbzda3hgvpstyfssllm 208 17 that that IN work_av4lzmkbbzda3hgvpstyfssllm 208 18 virtually virtually RB work_av4lzmkbbzda3hgvpstyfssllm 208 19 all all PDT work_av4lzmkbbzda3hgvpstyfssllm 208 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 208 21 transcript transcript NN work_av4lzmkbbzda3hgvpstyfssllm 208 22 present present NN work_av4lzmkbbzda3hgvpstyfssllm 208 23 uses use VBZ work_av4lzmkbbzda3hgvpstyfssllm 208 24 the the DT work_av4lzmkbbzda3hgvpstyfssllm 208 25 new new JJ work_av4lzmkbbzda3hgvpstyfssllm 208 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 208 27 more more RBR work_av4lzmkbbzda3hgvpstyfssllm 208 28 5′ 5′ JJ work_av4lzmkbbzda3hgvpstyfssllm 208 29 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 208 30 donor donor NN work_av4lzmkbbzda3hgvpstyfssllm 208 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 209 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 209 2 second second JJ work_av4lzmkbbzda3hgvpstyfssllm 209 3 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 209 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 209 5 this this DT work_av4lzmkbbzda3hgvpstyfssllm 209 6 compound compound JJ work_av4lzmkbbzda3hgvpstyfssllm 209 7 heterozygous heterozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 209 8 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 209 9 does do VBZ work_av4lzmkbbzda3hgvpstyfssllm 209 10 not not RB work_av4lzmkbbzda3hgvpstyfssllm 209 11 produce produce VB work_av4lzmkbbzda3hgvpstyfssllm 209 12 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 209 13 RNA RNA NNP work_av4lzmkbbzda3hgvpstyfssllm 209 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 210 1 wt wt VB work_av4lzmkbbzda3hgvpstyfssllm 210 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 210 3 wild wild JJ work_av4lzmkbbzda3hgvpstyfssllm 210 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 210 5 type type NN work_av4lzmkbbzda3hgvpstyfssllm 210 6 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 210 7 mut mut NN work_av4lzmkbbzda3hgvpstyfssllm 210 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 210 9 mutant mutant NN work_av4lzmkbbzda3hgvpstyfssllm 210 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 211 1 502 502 CD work_av4lzmkbbzda3hgvpstyfssllm 211 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 211 3 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 211 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 211 5 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 211 6 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 211 7 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 211 8 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 211 9 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 211 10 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 211 11 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 211 12 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 211 13 | | CD work_av4lzmkbbzda3hgvpstyfssllm 211 14 Number Number NNP work_av4lzmkbbzda3hgvpstyfssllm 211 15 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 211 16 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 211 17 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 211 18 characterized characterize VBN work_av4lzmkbbzda3hgvpstyfssllm 211 19 by by IN work_av4lzmkbbzda3hgvpstyfssllm 211 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 211 21 fact fact NN work_av4lzmkbbzda3hgvpstyfssllm 211 22 that that IN work_av4lzmkbbzda3hgvpstyfssllm 211 23 almost almost RB work_av4lzmkbbzda3hgvpstyfssllm 211 24 every every DT work_av4lzmkbbzda3hgvpstyfssllm 211 25 proband proband NN work_av4lzmkbbzda3hgvpstyfssllm 211 26 had have VBD work_av4lzmkbbzda3hgvpstyfssllm 211 27 a a DT work_av4lzmkbbzda3hgvpstyfssllm 211 28 unique unique JJ work_av4lzmkbbzda3hgvpstyfssllm 211 29 genotype genotype NN work_av4lzmkbbzda3hgvpstyfssllm 211 30 with with IN work_av4lzmkbbzda3hgvpstyfssllm 211 31 no no DT work_av4lzmkbbzda3hgvpstyfssllm 211 32 prevalent prevalent JJ work_av4lzmkbbzda3hgvpstyfssllm 211 33 mutant mutant JJ work_av4lzmkbbzda3hgvpstyfssllm 211 34 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 211 35 for for IN work_av4lzmkbbzda3hgvpstyfssllm 211 36 either either DT work_av4lzmkbbzda3hgvpstyfssllm 211 37 gene gene NN work_av4lzmkbbzda3hgvpstyfssllm 211 38 . . . work_av4lzmkbbzda3hgvpstyfssllm 212 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 212 2 agreement agreement NN work_av4lzmkbbzda3hgvpstyfssllm 212 3 with with IN work_av4lzmkbbzda3hgvpstyfssllm 212 4 this this DT work_av4lzmkbbzda3hgvpstyfssllm 212 5 observation observation NN work_av4lzmkbbzda3hgvpstyfssllm 212 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 212 7 using use VBG work_av4lzmkbbzda3hgvpstyfssllm 212 8 allele allele NNP work_av4lzmkbbzda3hgvpstyfssllm 212 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 212 10 specific specific JJ work_av4lzmkbbzda3hgvpstyfssllm 212 11 oligonucleotide oligonucleotide NN work_av4lzmkbbzda3hgvpstyfssllm 212 12 analy- analy- NNP work_av4lzmkbbzda3hgvpstyfssllm 212 13 sis sis NN work_av4lzmkbbzda3hgvpstyfssllm 212 14 to to TO work_av4lzmkbbzda3hgvpstyfssllm 212 15 screen screen VB work_av4lzmkbbzda3hgvpstyfssllm 212 16 66 66 CD work_av4lzmkbbzda3hgvpstyfssllm 212 17 North north JJ work_av4lzmkbbzda3hgvpstyfssllm 212 18 American american JJ work_av4lzmkbbzda3hgvpstyfssllm 212 19 controls control NNS work_av4lzmkbbzda3hgvpstyfssllm 212 20 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 212 21 132 132 CD work_av4lzmkbbzda3hgvpstyfssllm 212 22 chro- chro- NN work_av4lzmkbbzda3hgvpstyfssllm 212 23 mosomes mosome NNS work_av4lzmkbbzda3hgvpstyfssllm 212 24 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 212 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 212 26 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 212 27 found find VBD work_av4lzmkbbzda3hgvpstyfssllm 212 28 only only RB work_av4lzmkbbzda3hgvpstyfssllm 212 29 a a DT work_av4lzmkbbzda3hgvpstyfssllm 212 30 single single JJ work_av4lzmkbbzda3hgvpstyfssllm 212 31 heterozygote heterozygote NN work_av4lzmkbbzda3hgvpstyfssllm 212 32 from from IN work_av4lzmkbbzda3hgvpstyfssllm 212 33 one one CD work_av4lzmkbbzda3hgvpstyfssllm 212 34 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 212 35 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 212 36 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 212 37 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 212 38 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 212 39 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 212 40 and and CC work_av4lzmkbbzda3hgvpstyfssllm 212 41 no no DT work_av4lzmkbbzda3hgvpstyfssllm 212 42 carriers carrier NNS work_av4lzmkbbzda3hgvpstyfssllm 212 43 for for IN work_av4lzmkbbzda3hgvpstyfssllm 212 44 the the DT work_av4lzmkbbzda3hgvpstyfssllm 212 45 others other NNS work_av4lzmkbbzda3hgvpstyfssllm 212 46 tested test VBN work_av4lzmkbbzda3hgvpstyfssllm 212 47 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 212 48 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 212 49 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 212 50 A289V A289V NNP work_av4lzmkbbzda3hgvpstyfssllm 212 51 , , , work_av4lzmkbbzda3hgvpstyfssllm 212 52 -L437P -L437P NNP work_av4lzmkbbzda3hgvpstyfssllm 212 53 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 212 54 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 212 55 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 212 56 E99Q E99Q NNP work_av4lzmkbbzda3hgvpstyfssllm 212 57 , , , work_av4lzmkbbzda3hgvpstyfssllm 212 58 -R193C -R193C NNP work_av4lzmkbbzda3hgvpstyfssllm 212 59 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 212 60 . . . work_av4lzmkbbzda3hgvpstyfssllm 213 1 For for IN work_av4lzmkbbzda3hgvpstyfssllm 213 2 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 213 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 213 4 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 213 5 assume assume VBP work_av4lzmkbbzda3hgvpstyfssllm 213 6 functional functional JJ work_av4lzmkbbzda3hgvpstyfssllm 213 7 significance significance NN work_av4lzmkbbzda3hgvpstyfssllm 213 8 for for IN work_av4lzmkbbzda3hgvpstyfssllm 213 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 213 10 frameshift frameshift NN work_av4lzmkbbzda3hgvpstyfssllm 213 11 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 213 12 Q421fs(+1 Q421fs(+1 NNP work_av4lzmkbbzda3hgvpstyfssllm 213 13 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 213 14 and and CC work_av4lzmkbbzda3hgvpstyfssllm 213 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 213 16 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 213 17 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 213 18 D532H D532H NNP work_av4lzmkbbzda3hgvpstyfssllm 213 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 213 20 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 213 21 alters alter VBZ work_av4lzmkbbzda3hgvpstyfssllm 213 22 splicing splice VBG work_av4lzmkbbzda3hgvpstyfssllm 213 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 213 24 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 213 25 5a 5a NNP work_av4lzmkbbzda3hgvpstyfssllm 213 26 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 213 27 , , , work_av4lzmkbbzda3hgvpstyfssllm 213 28 because because IN work_av4lzmkbbzda3hgvpstyfssllm 213 29 both both DT work_av4lzmkbbzda3hgvpstyfssllm 213 30 result result VBP work_av4lzmkbbzda3hgvpstyfssllm 213 31 in in IN work_av4lzmkbbzda3hgvpstyfssllm 213 32 truncated truncate VBN work_av4lzmkbbzda3hgvpstyfssllm 213 33 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 213 34 lacking lack VBG work_av4lzmkbbzda3hgvpstyfssllm 213 35 func- func- XX work_av4lzmkbbzda3hgvpstyfssllm 213 36 tionally tionally RB work_av4lzmkbbzda3hgvpstyfssllm 213 37 important important JJ work_av4lzmkbbzda3hgvpstyfssllm 213 38 domains domain NNS work_av4lzmkbbzda3hgvpstyfssllm 213 39 . . . work_av4lzmkbbzda3hgvpstyfssllm 214 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 214 2 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 214 3 mutations mutation VBZ work_av4lzmkbbzda3hgvpstyfssllm 214 4 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 214 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 214 6 A289V A289V NNP work_av4lzmkbbzda3hgvpstyfssllm 214 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 214 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 214 9 L437P L437P NNP work_av4lzmkbbzda3hgvpstyfssllm 214 10 all all DT work_av4lzmkbbzda3hgvpstyfssllm 214 11 change change VBP work_av4lzmkbbzda3hgvpstyfssllm 214 12 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 214 13 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 214 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 214 15 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 214 16 3a 3a NNP work_av4lzmkbbzda3hgvpstyfssllm 214 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 214 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 214 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 214 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 214 21 corresponding correspond VBG work_av4lzmkbbzda3hgvpstyfssllm 214 22 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 214 23 con- con- NNP work_av4lzmkbbzda3hgvpstyfssllm 214 24 fer fer VBP work_av4lzmkbbzda3hgvpstyfssllm 214 25 no no DT work_av4lzmkbbzda3hgvpstyfssllm 214 26 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 214 27 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 214 28 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 214 29 when when WRB work_av4lzmkbbzda3hgvpstyfssllm 214 30 expressed express VBN work_av4lzmkbbzda3hgvpstyfssllm 214 31 in in IN work_av4lzmkbbzda3hgvpstyfssllm 214 32 the the DT work_av4lzmkbbzda3hgvpstyfssllm 214 33 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 214 34 reference reference NN work_av4lzmkbbzda3hgvpstyfssllm 214 35 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 214 36 line line NN work_av4lzmkbbzda3hgvpstyfssllm 214 37 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 214 38 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 214 39 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 214 40 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 214 41 . . . work_av4lzmkbbzda3hgvpstyfssllm 215 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 215 2 contrast contrast NN work_av4lzmkbbzda3hgvpstyfssllm 215 3 to to IN work_av4lzmkbbzda3hgvpstyfssllm 215 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 215 5 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 215 6 four four CD work_av4lzmkbbzda3hgvpstyfssllm 215 7 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 215 8 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 215 9 tested test VBN work_av4lzmkbbzda3hgvpstyfssllm 215 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 215 11 who who WP work_av4lzmkbbzda3hgvpstyfssllm 215 12 had have VBD work_av4lzmkbbzda3hgvpstyfssllm 215 13 no no DT work_av4lzmkbbzda3hgvpstyfssllm 215 14 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 215 15 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 215 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 215 17 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 215 18 detected detect VBD work_av4lzmkbbzda3hgvpstyfssllm 215 19 normal normal JJ work_av4lzmkbbzda3hgvpstyfssllm 215 20 amounts amount NNS work_av4lzmkbbzda3hgvpstyfssllm 215 21 of of IN work_av4lzmkbbzda3hgvpstyfssllm 215 22 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 215 23 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 215 24 in in IN work_av4lzmkbbzda3hgvpstyfssllm 215 25 the the DT work_av4lzmkbbzda3hgvpstyfssllm 215 26 proband proband NN work_av4lzmkbbzda3hgvpstyfssllm 215 27 011 011 CD work_av4lzmkbbzda3hgvpstyfssllm 215 28 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 215 29 for for IN work_av4lzmkbbzda3hgvpstyfssllm 215 30 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 215 31 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 215 32 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 215 33 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 215 34 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 215 35 . . . work_av4lzmkbbzda3hgvpstyfssllm 216 1 This this DT work_av4lzmkbbzda3hgvpstyfssllm 216 2 result result NN work_av4lzmkbbzda3hgvpstyfssllm 216 3 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 216 4 consistent consistent JJ work_av4lzmkbbzda3hgvpstyfssllm 216 5 with with IN work_av4lzmkbbzda3hgvpstyfssllm 216 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 216 7 pre- pre- NN work_av4lzmkbbzda3hgvpstyfssllm 216 8 diction diction NN work_av4lzmkbbzda3hgvpstyfssllm 216 9 based base VBN work_av4lzmkbbzda3hgvpstyfssllm 216 10 on on IN work_av4lzmkbbzda3hgvpstyfssllm 216 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 216 12 structure structure NN work_av4lzmkbbzda3hgvpstyfssllm 216 13 of of IN work_av4lzmkbbzda3hgvpstyfssllm 216 14 the the DT work_av4lzmkbbzda3hgvpstyfssllm 216 15 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 216 16 carboxyla- carboxyla- NN work_av4lzmkbbzda3hgvpstyfssllm 216 17 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 216 18 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 216 19 of of IN work_av4lzmkbbzda3hgvpstyfssllm 216 20 E. E. NNP work_av4lzmkbbzda3hgvpstyfssllm 216 21 coli coli NNS work_av4lzmkbbzda3hgvpstyfssllm 216 22 ACC ACC NNP work_av4lzmkbbzda3hgvpstyfssllm 216 23 that that IN work_av4lzmkbbzda3hgvpstyfssllm 216 24 the the DT work_av4lzmkbbzda3hgvpstyfssllm 216 25 residue residue NN work_av4lzmkbbzda3hgvpstyfssllm 216 26 correspon- correspon- NN work_av4lzmkbbzda3hgvpstyfssllm 216 27 ding de VBG work_av4lzmkbbzda3hgvpstyfssllm 216 28 to to IN work_av4lzmkbbzda3hgvpstyfssllm 216 29 MCCα MCCα NNP work_av4lzmkbbzda3hgvpstyfssllm 216 30 R385 R385 NNP work_av4lzmkbbzda3hgvpstyfssllm 216 31 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 216 32 part part NN work_av4lzmkbbzda3hgvpstyfssllm 216 33 of of IN work_av4lzmkbbzda3hgvpstyfssllm 216 34 a a DT work_av4lzmkbbzda3hgvpstyfssllm 216 35 positively positively RB work_av4lzmkbbzda3hgvpstyfssllm 216 36 charged charge VBN work_av4lzmkbbzda3hgvpstyfssllm 216 37 pocket pocket NN work_av4lzmkbbzda3hgvpstyfssllm 216 38 for for IN work_av4lzmkbbzda3hgvpstyfssllm 216 39 bicarbonate bicarbonate JJ work_av4lzmkbbzda3hgvpstyfssllm 216 40 binding binding NN work_av4lzmkbbzda3hgvpstyfssllm 216 41 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 216 42 36 36 CD work_av4lzmkbbzda3hgvpstyfssllm 216 43 , , , work_av4lzmkbbzda3hgvpstyfssllm 216 44 37 37 CD work_av4lzmkbbzda3hgvpstyfssllm 216 45 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 216 46 . . . work_av4lzmkbbzda3hgvpstyfssllm 217 1 For for IN work_av4lzmkbbzda3hgvpstyfssllm 217 2 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 217 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 217 4 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 217 5 assume assume VBP work_av4lzmkbbzda3hgvpstyfssllm 217 6 functional functional JJ work_av4lzmkbbzda3hgvpstyfssllm 217 7 significance significance NN work_av4lzmkbbzda3hgvpstyfssllm 217 8 for for IN work_av4lzmkbbzda3hgvpstyfssllm 217 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 217 10 frameshift frameshift NN work_av4lzmkbbzda3hgvpstyfssllm 217 11 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 217 12 S173fs(+1 S173fs(+1 NNP work_av4lzmkbbzda3hgvpstyfssllm 217 13 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 217 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 217 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 217 16 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 217 17 site site NN work_av4lzmkbbzda3hgvpstyfssllm 217 18 muta- muta- NN work_av4lzmkbbzda3hgvpstyfssllm 217 19 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 217 20 In5ac-1G→A In5ac-1G→A NNP work_av4lzmkbbzda3hgvpstyfssllm 217 21 and and CC work_av4lzmkbbzda3hgvpstyfssllm 217 22 the the DT work_av4lzmkbbzda3hgvpstyfssllm 217 23 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 217 24 mutation mutation NN work_av4lzmkbbzda3hgvpstyfssllm 217 25 I437V I437V NNP work_av4lzmkbbzda3hgvpstyfssllm 217 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 217 27 which which WDT work_av4lzmkbbzda3hgvpstyfssllm 217 28 alters alter VBZ work_av4lzmkbbzda3hgvpstyfssllm 217 29 splicing splice VBG work_av4lzmkbbzda3hgvpstyfssllm 217 30 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 217 31 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 217 32 5b 5b NN work_av4lzmkbbzda3hgvpstyfssllm 217 33 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 217 34 . . . work_av4lzmkbbzda3hgvpstyfssllm 218 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 218 2 remaining remaining JJ work_av4lzmkbbzda3hgvpstyfssllm 218 3 six six CD work_av4lzmkbbzda3hgvpstyfssllm 218 4 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 218 5 missense missense NN work_av4lzmkbbzda3hgvpstyfssllm 218 6 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 218 7 all all DT work_av4lzmkbbzda3hgvpstyfssllm 218 8 change change NN work_av4lzmkbbzda3hgvpstyfssllm 218 9 conserved conserve VBN work_av4lzmkbbzda3hgvpstyfssllm 218 10 residues residue NNS work_av4lzmkbbzda3hgvpstyfssllm 218 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 218 12 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 218 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 218 14 only only JJ work_av4lzmkbbzda3hgvpstyfssllm 218 15 coding code VBG work_av4lzmkbbzda3hgvpstyfssllm 218 16 alterations alteration NNS work_av4lzmkbbzda3hgvpstyfssllm 218 17 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 218 18 found find VBD work_av4lzmkbbzda3hgvpstyfssllm 218 19 in in IN work_av4lzmkbbzda3hgvpstyfssllm 218 20 sequencing sequence VBG work_av4lzmkbbzda3hgvpstyfssllm 218 21 the the DT work_av4lzmkbbzda3hgvpstyfssllm 218 22 full full JJ work_av4lzmkbbzda3hgvpstyfssllm 218 23 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 218 24 length length NN work_av4lzmkbbzda3hgvpstyfssllm 218 25 ORF ORF NNP work_av4lzmkbbzda3hgvpstyfssllm 218 26 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 218 27 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 218 28 3b 3b NN work_av4lzmkbbzda3hgvpstyfssllm 218 29 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 218 30 . . . work_av4lzmkbbzda3hgvpstyfssllm 219 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 219 2 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 219 3 studies study NNS work_av4lzmkbbzda3hgvpstyfssllm 219 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 5 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 219 6 showed show VBD work_av4lzmkbbzda3hgvpstyfssllm 219 7 that that IN work_av4lzmkbbzda3hgvpstyfssllm 219 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 219 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 219 10 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 219 11 R155Q R155Q NNP work_av4lzmkbbzda3hgvpstyfssllm 219 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 13 -P310R -P310R NNP work_av4lzmkbbzda3hgvpstyfssllm 219 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 15 -S173L -S173L NNP work_av4lzmkbbzda3hgvpstyfssllm 219 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 219 18 -E99Q -E99Q : work_av4lzmkbbzda3hgvpstyfssllm 219 19 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 219 20 had have VBD work_av4lzmkbbzda3hgvpstyfssllm 219 21 no no DT work_av4lzmkbbzda3hgvpstyfssllm 219 22 detectable detectable JJ work_av4lzmkbbzda3hgvpstyfssllm 219 23 MCC mcc NN work_av4lzmkbbzda3hgvpstyfssllm 219 24 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 219 25 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 26 whereas whereas IN work_av4lzmkbbzda3hgvpstyfssllm 219 27 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 219 28 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 219 29 V339 V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 219 30 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 219 31 and and CC work_av4lzmkbbzda3hgvpstyfssllm 219 32 -R193C -R193C NNP work_av4lzmkbbzda3hgvpstyfssllm 219 33 had have VBD work_av4lzmkbbzda3hgvpstyfssllm 219 34 some some DT work_av4lzmkbbzda3hgvpstyfssllm 219 35 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 219 36 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 219 37 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 38 about about RB work_av4lzmkbbzda3hgvpstyfssllm 219 39 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 219 40 % % NN work_av4lzmkbbzda3hgvpstyfssllm 219 41 of of IN work_av4lzmkbbzda3hgvpstyfssllm 219 42 the the DT work_av4lzmkbbzda3hgvpstyfssllm 219 43 experimental experimental JJ work_av4lzmkbbzda3hgvpstyfssllm 219 44 control control NN work_av4lzmkbbzda3hgvpstyfssllm 219 45 value value NN work_av4lzmkbbzda3hgvpstyfssllm 219 46 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 219 47 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 219 48 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 219 49 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 219 50 , , , work_av4lzmkbbzda3hgvpstyfssllm 219 51 when when WRB work_av4lzmkbbzda3hgvpstyfssllm 219 52 expressed express VBN work_av4lzmkbbzda3hgvpstyfssllm 219 53 in in IN work_av4lzmkbbzda3hgvpstyfssllm 219 54 CG1-deficient cg1-deficient NN work_av4lzmkbbzda3hgvpstyfssllm 219 55 reference reference NN work_av4lzmkbbzda3hgvpstyfssllm 219 56 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 219 57 lines line NNS work_av4lzmkbbzda3hgvpstyfssllm 219 58 . . . work_av4lzmkbbzda3hgvpstyfssllm 220 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 220 2 identified identify VBD work_av4lzmkbbzda3hgvpstyfssllm 220 3 V339 V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 220 4 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 220 5 in in IN work_av4lzmkbbzda3hgvpstyfssllm 220 6 two two CD work_av4lzmkbbzda3hgvpstyfssllm 220 7 com- com- NN work_av4lzmkbbzda3hgvpstyfssllm 220 8 pound pound NN work_av4lzmkbbzda3hgvpstyfssllm 220 9 heterozygous heterozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 220 10 Turkish turkish JJ work_av4lzmkbbzda3hgvpstyfssllm 220 11 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 220 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 220 13 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 220 14 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 220 15 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 220 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 220 17 the the DT work_av4lzmkbbzda3hgvpstyfssllm 220 18 only only JJ work_av4lzmkbbzda3hgvpstyfssllm 220 19 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 220 20 in in IN work_av4lzmkbbzda3hgvpstyfssllm 220 21 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 220 22 collection collection NN work_av4lzmkbbzda3hgvpstyfssllm 220 23 with with IN work_av4lzmkbbzda3hgvpstyfssllm 220 24 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 220 25 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 220 26 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 220 27 in in IN work_av4lzmkbbzda3hgvpstyfssllm 220 28 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 220 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 221 1 Although although IN work_av4lzmkbbzda3hgvpstyfssllm 221 2 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 221 3 % % NN work_av4lzmkbbzda3hgvpstyfssllm 221 4 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 221 5 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 221 6 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 221 7 at at IN work_av4lzmkbbzda3hgvpstyfssllm 221 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 221 9 detec- detec- NNP work_av4lzmkbbzda3hgvpstyfssllm 221 10 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 221 11 limit limit NN work_av4lzmkbbzda3hgvpstyfssllm 221 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 221 13 the the DT work_av4lzmkbbzda3hgvpstyfssllm 221 14 standard standard JJ work_av4lzmkbbzda3hgvpstyfssllm 221 15 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 221 16 assay assay NNP work_av4lzmkbbzda3hgvpstyfssllm 221 17 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 221 18 used use VBD work_av4lzmkbbzda3hgvpstyfssllm 221 19 for for IN work_av4lzmkbbzda3hgvpstyfssllm 221 20 the the DT work_av4lzmkbbzda3hgvpstyfssllm 221 21 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 221 22 studies study NNS work_av4lzmkbbzda3hgvpstyfssllm 221 23 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 221 24 27 27 CD work_av4lzmkbbzda3hgvpstyfssllm 221 25 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 221 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 221 27 these these DT work_av4lzmkbbzda3hgvpstyfssllm 221 28 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 221 29 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 221 30 in in IN work_av4lzmkbbzda3hgvpstyfssllm 221 31 accordance accordance NN work_av4lzmkbbzda3hgvpstyfssllm 221 32 with with IN work_av4lzmkbbzda3hgvpstyfssllm 221 33 the the DT work_av4lzmkbbzda3hgvpstyfssllm 221 34 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 221 35 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 221 36 detect- detect- JJ work_av4lzmkbbzda3hgvpstyfssllm 221 37 ed ed NNP work_av4lzmkbbzda3hgvpstyfssllm 221 38 in in IN work_av4lzmkbbzda3hgvpstyfssllm 221 39 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 221 40 of of IN work_av4lzmkbbzda3hgvpstyfssllm 221 41 these these DT work_av4lzmkbbzda3hgvpstyfssllm 221 42 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 221 43 with with IN work_av4lzmkbbzda3hgvpstyfssllm 221 44 a a DT work_av4lzmkbbzda3hgvpstyfssllm 221 45 modi- modi- NN work_av4lzmkbbzda3hgvpstyfssllm 221 46 fied fie VBN work_av4lzmkbbzda3hgvpstyfssllm 221 47 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 221 48 assay assay NN work_av4lzmkbbzda3hgvpstyfssllm 221 49 of of IN work_av4lzmkbbzda3hgvpstyfssllm 221 50 increased increase VBN work_av4lzmkbbzda3hgvpstyfssllm 221 51 sensitivity sensitivity NN work_av4lzmkbbzda3hgvpstyfssllm 221 52 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 221 53 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 221 54 , , , work_av4lzmkbbzda3hgvpstyfssllm 221 55 22 22 CD work_av4lzmkbbzda3hgvpstyfssllm 221 56 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 221 57 . . . work_av4lzmkbbzda3hgvpstyfssllm 222 1 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 222 2 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 222 3 reduced reduce VBN work_av4lzmkbbzda3hgvpstyfssllm 222 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 222 5 but but CC work_av4lzmkbbzda3hgvpstyfssllm 222 6 clearly clearly RB work_av4lzmkbbzda3hgvpstyfssllm 222 7 present present JJ work_av4lzmkbbzda3hgvpstyfssllm 222 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 222 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 222 10 all all DT work_av4lzmkbbzda3hgvpstyfssllm 222 11 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 222 12 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 222 13 lines line NNS work_av4lzmkbbzda3hgvpstyfssllm 222 14 in in IN work_av4lzmkbbzda3hgvpstyfssllm 222 15 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 222 16 biochemical biochemical JJ work_av4lzmkbbzda3hgvpstyfssllm 222 17 detection detection NN work_av4lzmkbbzda3hgvpstyfssllm 222 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 222 19 the the DT work_av4lzmkbbzda3hgvpstyfssllm 222 20 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 222 21 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 222 22 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 222 23 α α NNP work_av4lzmkbbzda3hgvpstyfssllm 222 24 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 222 25 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 222 26 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 222 27 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 222 28 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 222 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 223 1 This this DT work_av4lzmkbbzda3hgvpstyfssllm 223 2 suggests suggest VBZ work_av4lzmkbbzda3hgvpstyfssllm 223 3 that that IN work_av4lzmkbbzda3hgvpstyfssllm 223 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 223 5 MCCα MCCα NNS work_av4lzmkbbzda3hgvpstyfssllm 223 6 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 223 7 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 223 8 less less RBR work_av4lzmkbbzda3hgvpstyfssllm 223 9 stable stable JJ work_av4lzmkbbzda3hgvpstyfssllm 223 10 when when WRB work_av4lzmkbbzda3hgvpstyfssllm 223 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 223 12 β β NNP work_av4lzmkbbzda3hgvpstyfssllm 223 13 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 223 14 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 223 15 absent absent JJ work_av4lzmkbbzda3hgvpstyfssllm 223 16 or or CC work_av4lzmkbbzda3hgvpstyfssllm 223 17 defective defective JJ work_av4lzmkbbzda3hgvpstyfssllm 223 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 224 1 Interestingly interestingly RB work_av4lzmkbbzda3hgvpstyfssllm 224 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 224 3 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 224 4 detected detect VBD work_av4lzmkbbzda3hgvpstyfssllm 224 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 224 6 MCCβ MCCβ NNS work_av4lzmkbbzda3hgvpstyfssllm 224 7 S173fs(+1 S173fs(+1 NNP work_av4lzmkbbzda3hgvpstyfssllm 224 8 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 224 9 , , , work_av4lzmkbbzda3hgvpstyfssllm 224 10 a a DT work_av4lzmkbbzda3hgvpstyfssllm 224 11 T t NN work_av4lzmkbbzda3hgvpstyfssllm 224 12 insertion insertion NN work_av4lzmkbbzda3hgvpstyfssllm 224 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 224 14 as as IN work_av4lzmkbbzda3hgvpstyfssllm 224 15 one one CD work_av4lzmkbbzda3hgvpstyfssllm 224 16 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 224 17 in in IN work_av4lzmkbbzda3hgvpstyfssllm 224 18 a a DT work_av4lzmkbbzda3hgvpstyfssllm 224 19 mild- mild- NN work_av4lzmkbbzda3hgvpstyfssllm 224 20 ly ly XX work_av4lzmkbbzda3hgvpstyfssllm 224 21 affected affected JJ work_av4lzmkbbzda3hgvpstyfssllm 224 22 Swiss swiss JJ work_av4lzmkbbzda3hgvpstyfssllm 224 23 compound compound NN work_av4lzmkbbzda3hgvpstyfssllm 224 24 heterozygote heterozygote NN work_av4lzmkbbzda3hgvpstyfssllm 224 25 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 224 26 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 224 27 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 224 28 and and CC work_av4lzmkbbzda3hgvpstyfssllm 224 29 in in IN work_av4lzmkbbzda3hgvpstyfssllm 224 30 an an DT work_av4lzmkbbzda3hgvpstyfssllm 224 31 asymptomatic asymptomatic JJ work_av4lzmkbbzda3hgvpstyfssllm 224 32 Mennonite Mennonite NNP work_av4lzmkbbzda3hgvpstyfssllm 224 33 homozy- homozy- NN work_av4lzmkbbzda3hgvpstyfssllm 224 34 gote gote NN work_av4lzmkbbzda3hgvpstyfssllm 224 35 from from IN work_av4lzmkbbzda3hgvpstyfssllm 224 36 Lancaster Lancaster NNP work_av4lzmkbbzda3hgvpstyfssllm 224 37 County County NNP work_av4lzmkbbzda3hgvpstyfssllm 224 38 , , , work_av4lzmkbbzda3hgvpstyfssllm 224 39 Pennsylvania Pennsylvania NNP work_av4lzmkbbzda3hgvpstyfssllm 224 40 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 224 41 Table Table NNP work_av4lzmkbbzda3hgvpstyfssllm 224 42 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 224 43 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 224 44 . . . work_av4lzmkbbzda3hgvpstyfssllm 225 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 225 2 ancestors ancestor NNS work_av4lzmkbbzda3hgvpstyfssllm 225 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 225 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 225 5 Lancaster Lancaster NNP work_av4lzmkbbzda3hgvpstyfssllm 225 6 County County NNP work_av4lzmkbbzda3hgvpstyfssllm 225 7 Amish Amish NNP work_av4lzmkbbzda3hgvpstyfssllm 225 8 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 225 9 Men- Men- NNP work_av4lzmkbbzda3hgvpstyfssllm 225 10 nonite nonite NNP work_av4lzmkbbzda3hgvpstyfssllm 225 11 population population NNP work_av4lzmkbbzda3hgvpstyfssllm 225 12 originated originate VBD work_av4lzmkbbzda3hgvpstyfssllm 225 13 from from IN work_av4lzmkbbzda3hgvpstyfssllm 225 14 Switzerland Switzerland NNP work_av4lzmkbbzda3hgvpstyfssllm 225 15 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 225 16 41 41 CD work_av4lzmkbbzda3hgvpstyfssllm 225 17 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 225 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 225 19 may may MD work_av4lzmkbbzda3hgvpstyfssllm 225 20 have have VB work_av4lzmkbbzda3hgvpstyfssllm 225 21 brought bring VBN work_av4lzmkbbzda3hgvpstyfssllm 225 22 this this DT work_av4lzmkbbzda3hgvpstyfssllm 225 23 allele allele NN work_av4lzmkbbzda3hgvpstyfssllm 225 24 with with IN work_av4lzmkbbzda3hgvpstyfssllm 225 25 them -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 225 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 226 1 Haplotype Haplotype NNP work_av4lzmkbbzda3hgvpstyfssllm 226 2 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 226 3 will will MD work_av4lzmkbbzda3hgvpstyfssllm 226 4 be be VB work_av4lzmkbbzda3hgvpstyfssllm 226 5 necessary necessary JJ work_av4lzmkbbzda3hgvpstyfssllm 226 6 to to TO work_av4lzmkbbzda3hgvpstyfssllm 226 7 confirm confirm VB work_av4lzmkbbzda3hgvpstyfssllm 226 8 a a DT work_av4lzmkbbzda3hgvpstyfssllm 226 9 founder founder NN work_av4lzmkbbzda3hgvpstyfssllm 226 10 muta- muta- NN work_av4lzmkbbzda3hgvpstyfssllm 226 11 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 226 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 227 1 Moreover moreover RB work_av4lzmkbbzda3hgvpstyfssllm 227 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 227 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 227 4 Amish amish JJ work_av4lzmkbbzda3hgvpstyfssllm 227 5 proband proband NN work_av4lzmkbbzda3hgvpstyfssllm 227 6 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 227 7 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 227 8 for for IN work_av4lzmkbbzda3hgvpstyfssllm 227 9 a a DT work_av4lzmkbbzda3hgvpstyfssllm 227 10 different different JJ work_av4lzmkbbzda3hgvpstyfssllm 227 11 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 227 12 allele allele NNP work_av4lzmkbbzda3hgvpstyfssllm 227 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 227 14 E99Q. e99q. ADD work_av4lzmkbbzda3hgvpstyfssllm 228 1 Thus thus RB work_av4lzmkbbzda3hgvpstyfssllm 228 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 228 3 despite despite IN work_av4lzmkbbzda3hgvpstyfssllm 228 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 228 5 small small JJ work_av4lzmkbbzda3hgvpstyfssllm 228 6 size size NN work_av4lzmkbbzda3hgvpstyfssllm 228 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 228 8 common common JJ work_av4lzmkbbzda3hgvpstyfssllm 228 9 origins origin NNS work_av4lzmkbbzda3hgvpstyfssllm 228 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 228 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 228 12 Amish amish JJ work_av4lzmkbbzda3hgvpstyfssllm 228 13 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 228 14 Mennonite Mennonite NNP work_av4lzmkbbzda3hgvpstyfssllm 228 15 population population NN work_av4lzmkbbzda3hgvpstyfssllm 228 16 in in IN work_av4lzmkbbzda3hgvpstyfssllm 228 17 this this DT work_av4lzmkbbzda3hgvpstyfssllm 228 18 region region NN work_av4lzmkbbzda3hgvpstyfssllm 228 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 228 20 there there EX work_av4lzmkbbzda3hgvpstyfssllm 228 21 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 228 22 allelic allelic JJ work_av4lzmkbbzda3hgvpstyfssllm 228 23 heterogeneity heterogeneity NN work_av4lzmkbbzda3hgvpstyfssllm 228 24 for for IN work_av4lzmkbbzda3hgvpstyfssllm 228 25 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 228 26 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 228 27 . . . work_av4lzmkbbzda3hgvpstyfssllm 229 1 Combining combine VBG work_av4lzmkbbzda3hgvpstyfssllm 229 2 our -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 229 3 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 229 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 229 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 229 6 published publish VBN work_av4lzmkbbzda3hgvpstyfssllm 229 7 clinical clinical JJ work_av4lzmkbbzda3hgvpstyfssllm 229 8 reports report NNS work_av4lzmkbbzda3hgvpstyfssllm 229 9 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 229 10 2–4 2–4 NNS work_av4lzmkbbzda3hgvpstyfssllm 229 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 229 12 19–25 19–25 CD work_av4lzmkbbzda3hgvpstyfssllm 229 13 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 229 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 229 15 we -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 229 16 were be VBD work_av4lzmkbbzda3hgvpstyfssllm 229 17 not not RB work_av4lzmkbbzda3hgvpstyfssllm 229 18 able able JJ work_av4lzmkbbzda3hgvpstyfssllm 229 19 to to TO work_av4lzmkbbzda3hgvpstyfssllm 229 20 discern discern VB work_av4lzmkbbzda3hgvpstyfssllm 229 21 a a DT work_av4lzmkbbzda3hgvpstyfssllm 229 22 phenotype phenotype JJ work_av4lzmkbbzda3hgvpstyfssllm 229 23 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 229 24 genotype genotype NN work_av4lzmkbbzda3hgvpstyfssllm 229 25 correlation correlation NN work_av4lzmkbbzda3hgvpstyfssllm 229 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 230 1 Probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 230 2 010 010 CD work_av4lzmkbbzda3hgvpstyfssllm 230 3 and and CC work_av4lzmkbbzda3hgvpstyfssllm 230 4 015 015 CD work_av4lzmkbbzda3hgvpstyfssllm 230 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 230 6 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 230 7 for for IN work_av4lzmkbbzda3hgvpstyfssllm 230 8 truncating truncate VBG work_av4lzmkbbzda3hgvpstyfssllm 230 9 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 230 10 in in IN work_av4lzmkbbzda3hgvpstyfssllm 230 11 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 230 12 or or CC work_av4lzmkbbzda3hgvpstyfssllm 230 13 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 230 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 230 15 Tables Tables NNP work_av4lzmkbbzda3hgvpstyfssllm 230 16 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 230 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 230 18 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 230 19 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 230 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 230 21 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 230 22 , , , work_av4lzmkbbzda3hgvpstyfssllm 230 23 in in IN work_av4lzmkbbzda3hgvpstyfssllm 230 24 one one CD work_av4lzmkbbzda3hgvpstyfssllm 230 25 case case NN work_av4lzmkbbzda3hgvpstyfssllm 230 26 , , , work_av4lzmkbbzda3hgvpstyfssllm 230 27 no no DT work_av4lzmkbbzda3hgvpstyfssllm 230 28 symp- symp- JJ work_av4lzmkbbzda3hgvpstyfssllm 230 29 toms tom NNS work_av4lzmkbbzda3hgvpstyfssllm 230 30 and and CC work_av4lzmkbbzda3hgvpstyfssllm 230 31 , , , work_av4lzmkbbzda3hgvpstyfssllm 230 32 in in IN work_av4lzmkbbzda3hgvpstyfssllm 230 33 the the DT work_av4lzmkbbzda3hgvpstyfssllm 230 34 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 230 35 , , , work_av4lzmkbbzda3hgvpstyfssllm 230 36 a a DT work_av4lzmkbbzda3hgvpstyfssllm 230 37 mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 230 38 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 230 39 with with IN work_av4lzmkbbzda3hgvpstyfssllm 230 40 late late JJ work_av4lzmkbbzda3hgvpstyfssllm 230 41 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 230 42 and and CC work_av4lzmkbbzda3hgvpstyfssllm 230 43 no no DT work_av4lzmkbbzda3hgvpstyfssllm 230 44 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 230 45 damage damage NN work_av4lzmkbbzda3hgvpstyfssllm 230 46 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 230 47 23 23 CD work_av4lzmkbbzda3hgvpstyfssllm 230 48 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 230 49 . . . work_av4lzmkbbzda3hgvpstyfssllm 231 1 By by IN work_av4lzmkbbzda3hgvpstyfssllm 231 2 contrast contrast NN work_av4lzmkbbzda3hgvpstyfssllm 231 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 4 probands proband NNS work_av4lzmkbbzda3hgvpstyfssllm 231 5 011 011 CD work_av4lzmkbbzda3hgvpstyfssllm 231 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 7 001 001 CD work_av4lzmkbbzda3hgvpstyfssllm 231 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 231 10 002 002 CD work_av4lzmkbbzda3hgvpstyfssllm 231 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 12 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 231 13 for for IN work_av4lzmkbbzda3hgvpstyfssllm 231 14 mis- mis- NN work_av4lzmkbbzda3hgvpstyfssllm 231 15 sense sense NN work_av4lzmkbbzda3hgvpstyfssllm 231 16 mutations mutation NNS work_av4lzmkbbzda3hgvpstyfssllm 231 17 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 231 18 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 231 19 R385S R385S NNP work_av4lzmkbbzda3hgvpstyfssllm 231 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 21 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 231 22 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 231 23 S173L S173L NNP work_av4lzmkbbzda3hgvpstyfssllm 231 24 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 25 and and CC work_av4lzmkbbzda3hgvpstyfssllm 231 26 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 231 27 E99Q E99Q NNP work_av4lzmkbbzda3hgvpstyfssllm 231 28 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 29 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 231 30 a a DT work_av4lzmkbbzda3hgvpstyfssllm 231 31 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 231 32 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 231 33 with with IN work_av4lzmkbbzda3hgvpstyfssllm 231 34 early early JJ work_av4lzmkbbzda3hgvpstyfssllm 231 35 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 231 36 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 231 37 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 38 major major JJ work_av4lzmkbbzda3hgvpstyfssllm 231 39 neurological neurological JJ work_av4lzmkbbzda3hgvpstyfssllm 231 40 involvement involvement NN work_av4lzmkbbzda3hgvpstyfssllm 231 41 and and CC work_av4lzmkbbzda3hgvpstyfssllm 231 42 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 43 in in IN work_av4lzmkbbzda3hgvpstyfssllm 231 44 one one CD work_av4lzmkbbzda3hgvpstyfssllm 231 45 case case NN work_av4lzmkbbzda3hgvpstyfssllm 231 46 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 47 a a DT work_av4lzmkbbzda3hgvpstyfssllm 231 48 fatal fatal JJ work_av4lzmkbbzda3hgvpstyfssllm 231 49 outcome outcome NN work_av4lzmkbbzda3hgvpstyfssllm 231 50 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 231 51 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 231 52 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 231 53 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 231 54 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 231 55 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 231 56 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 57 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 231 58 , , , work_av4lzmkbbzda3hgvpstyfssllm 231 59 24 24 CD work_av4lzmkbbzda3hgvpstyfssllm 231 60 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 231 61 . . . work_av4lzmkbbzda3hgvpstyfssllm 232 1 Proband Proband NNP work_av4lzmkbbzda3hgvpstyfssllm 232 2 016 016 NNP work_av4lzmkbbzda3hgvpstyfssllm 232 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 232 4 an an DT work_av4lzmkbbzda3hgvpstyfssllm 232 5 adult adult NN work_av4lzmkbbzda3hgvpstyfssllm 232 6 Amish amish JJ work_av4lzmkbbzda3hgvpstyfssllm 232 7 patient patient NN work_av4lzmkbbzda3hgvpstyfssllm 232 8 homozygous homozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 232 9 for for IN work_av4lzmkbbzda3hgvpstyfssllm 232 10 the the DT work_av4lzmkbbzda3hgvpstyfssllm 232 11 same same JJ work_av4lzmkbbzda3hgvpstyfssllm 232 12 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 232 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 232 14 E99Q E99Q NNP work_av4lzmkbbzda3hgvpstyfssllm 232 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 232 16 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 232 17 only only RB work_av4lzmkbbzda3hgvpstyfssllm 232 18 mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 232 19 symptoms symptom NNS work_av4lzmkbbzda3hgvpstyfssllm 232 20 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 232 21 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 232 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 232 23 . . . work_av4lzmkbbzda3hgvpstyfssllm 233 1 Further- Further- NNP work_av4lzmkbbzda3hgvpstyfssllm 233 2 more more RBR work_av4lzmkbbzda3hgvpstyfssllm 233 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 233 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 233 5 two two CD work_av4lzmkbbzda3hgvpstyfssllm 233 6 Turkish turkish JJ work_av4lzmkbbzda3hgvpstyfssllm 233 7 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 233 8 with with IN work_av4lzmkbbzda3hgvpstyfssllm 233 9 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 233 10 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 233 11 V339 V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 233 12 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 233 13 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 233 14 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 233 15 some some DT work_av4lzmkbbzda3hgvpstyfssllm 233 16 residual residual JJ work_av4lzmkbbzda3hgvpstyfssllm 233 17 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 233 18 activity activity NN work_av4lzmkbbzda3hgvpstyfssllm 233 19 both both DT work_av4lzmkbbzda3hgvpstyfssllm 233 20 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 233 21 a a DT work_av4lzmkbbzda3hgvpstyfssllm 233 22 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 233 23 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 233 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 234 1 Taken take VBN work_av4lzmkbbzda3hgvpstyfssllm 234 2 together together RB work_av4lzmkbbzda3hgvpstyfssllm 234 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 234 4 these these DT work_av4lzmkbbzda3hgvpstyfssllm 234 5 results result NNS work_av4lzmkbbzda3hgvpstyfssllm 234 6 sug- sug- RB work_av4lzmkbbzda3hgvpstyfssllm 234 7 gest g JJS work_av4lzmkbbzda3hgvpstyfssllm 234 8 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 234 9 factors factor NNS work_av4lzmkbbzda3hgvpstyfssllm 234 10 other other JJ work_av4lzmkbbzda3hgvpstyfssllm 234 11 than than IN work_av4lzmkbbzda3hgvpstyfssllm 234 12 the the DT work_av4lzmkbbzda3hgvpstyfssllm 234 13 genotype genotype NN work_av4lzmkbbzda3hgvpstyfssllm 234 14 at at IN work_av4lzmkbbzda3hgvpstyfssllm 234 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 234 16 Table Table NNP work_av4lzmkbbzda3hgvpstyfssllm 234 17 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 234 18 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 234 19 mutant mutant NN work_av4lzmkbbzda3hgvpstyfssllm 234 20 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 234 21 No no UH work_av4lzmkbbzda3hgvpstyfssllm 234 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 235 1 Allele Allele NNP work_av4lzmkbbzda3hgvpstyfssllm 235 2 Exon Exon NNP work_av4lzmkbbzda3hgvpstyfssllm 235 3 Nucleotide Nucleotide NNP work_av4lzmkbbzda3hgvpstyfssllm 235 4 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 235 5 Ethnic ethnic JJ work_av4lzmkbbzda3hgvpstyfssllm 235 6 Proband Proband NNP work_av4lzmkbbzda3hgvpstyfssllm 235 7 change change NN work_av4lzmkbbzda3hgvpstyfssllm 235 8 phenotypeA phenotypeA NNP work_av4lzmkbbzda3hgvpstyfssllm 235 9 origin origin NN work_av4lzmkbbzda3hgvpstyfssllm 235 10 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 235 11 R155Q r155q CD work_av4lzmkbbzda3hgvpstyfssllm 235 12 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 235 13 464G→A 464g→a CD work_av4lzmkbbzda3hgvpstyfssllm 235 14 Mild Mild NNP work_av4lzmkbbzda3hgvpstyfssllm 235 15 Vietnamese Vietnamese NNP work_av4lzmkbbzda3hgvpstyfssllm 235 16 006 006 CD work_av4lzmkbbzda3hgvpstyfssllm 235 17 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 235 18 P310R P310R NNP work_av4lzmkbbzda3hgvpstyfssllm 235 19 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 235 20 929C→G 929c→g CD work_av4lzmkbbzda3hgvpstyfssllm 235 21 Mild Mild NNP work_av4lzmkbbzda3hgvpstyfssllm 235 22 Vietnamese Vietnamese NNP work_av4lzmkbbzda3hgvpstyfssllm 235 23 006 006 CD work_av4lzmkbbzda3hgvpstyfssllm 235 24 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 235 25 S173fs(+1 s173fs(+1 CD work_av4lzmkbbzda3hgvpstyfssllm 235 26 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 235 27 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 235 28 518insT 518inst CD work_av4lzmkbbzda3hgvpstyfssllm 235 29 Mild Mild NNP work_av4lzmkbbzda3hgvpstyfssllm 235 30 Swiss Swiss NNP work_av4lzmkbbzda3hgvpstyfssllm 235 31 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 235 32 MennoniteB MennoniteB NNP work_av4lzmkbbzda3hgvpstyfssllm 235 33 004C 004C NNP work_av4lzmkbbzda3hgvpstyfssllm 235 34 , , , work_av4lzmkbbzda3hgvpstyfssllm 235 35 015D 015D NNP work_av4lzmkbbzda3hgvpstyfssllm 235 36 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 235 37 I437V i437v CD work_av4lzmkbbzda3hgvpstyfssllm 235 38 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 235 39 1309A→GE 1309a→ge CD work_av4lzmkbbzda3hgvpstyfssllm 235 40 Mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 235 41 Dutch dutch JJ work_av4lzmkbbzda3hgvpstyfssllm 235 42 003C 003c CD work_av4lzmkbbzda3hgvpstyfssllm 235 43 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 235 44 R193C r193c CD work_av4lzmkbbzda3hgvpstyfssllm 235 45 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 235 46 577C→T 577c→t CD work_av4lzmkbbzda3hgvpstyfssllm 235 47 Mild Mild NNP work_av4lzmkbbzda3hgvpstyfssllm 235 48 Dutch Dutch NNP work_av4lzmkbbzda3hgvpstyfssllm 235 49 005 005 CD work_av4lzmkbbzda3hgvpstyfssllm 235 50 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 235 51 In5ac-1G→A In5ac-1G→A NNP work_av4lzmkbbzda3hgvpstyfssllm 235 52 In5ac-1G→A In5ac-1G→A NNP work_av4lzmkbbzda3hgvpstyfssllm 235 53 Mild Mild NNP work_av4lzmkbbzda3hgvpstyfssllm 235 54 Dutch Dutch NNP work_av4lzmkbbzda3hgvpstyfssllm 235 55 005 005 CD work_av4lzmkbbzda3hgvpstyfssllm 235 56 7 7 CD work_av4lzmkbbzda3hgvpstyfssllm 235 57 S173L s173l CD work_av4lzmkbbzda3hgvpstyfssllm 235 58 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 235 59 518C→T 518c→t CD work_av4lzmkbbzda3hgvpstyfssllm 235 60 Severe Severe NNP work_av4lzmkbbzda3hgvpstyfssllm 235 61 Turkish Turkish NNP work_av4lzmkbbzda3hgvpstyfssllm 235 62 001D 001D NNP work_av4lzmkbbzda3hgvpstyfssllm 235 63 8 8 CD work_av4lzmkbbzda3hgvpstyfssllm 235 64 E99Q e99q NN work_av4lzmkbbzda3hgvpstyfssllm 235 65 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 235 66 295G→C 295g→c CD work_av4lzmkbbzda3hgvpstyfssllm 235 67 Severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 235 68 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 235 69 mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 235 70 Turkish turkish JJ work_av4lzmkbbzda3hgvpstyfssllm 235 71 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 235 72 Amish Amish NNP work_av4lzmkbbzda3hgvpstyfssllm 235 73 002D 002D NNP work_av4lzmkbbzda3hgvpstyfssllm 235 74 , , , work_av4lzmkbbzda3hgvpstyfssllm 235 75 016D 016d $ work_av4lzmkbbzda3hgvpstyfssllm 235 76 9 9 CD work_av4lzmkbbzda3hgvpstyfssllm 235 77 V339 v339 NN work_av4lzmkbbzda3hgvpstyfssllm 235 78 M m CD work_av4lzmkbbzda3hgvpstyfssllm 235 79 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 235 80 1015G→A 1015g→a CD work_av4lzmkbbzda3hgvpstyfssllm 235 81 Severe Severe NNP work_av4lzmkbbzda3hgvpstyfssllm 235 82 Turkish Turkish NNP work_av4lzmkbbzda3hgvpstyfssllm 235 83 007C 007C NNP work_av4lzmkbbzda3hgvpstyfssllm 235 84 , , , work_av4lzmkbbzda3hgvpstyfssllm 235 85 008C 008c CD work_av4lzmkbbzda3hgvpstyfssllm 235 86 AMild amild NN work_av4lzmkbbzda3hgvpstyfssllm 235 87 : : : work_av4lzmkbbzda3hgvpstyfssllm 235 88 late late JJ work_av4lzmkbbzda3hgvpstyfssllm 235 89 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 235 90 , , , work_av4lzmkbbzda3hgvpstyfssllm 235 91 good good JJ work_av4lzmkbbzda3hgvpstyfssllm 235 92 recovery recovery NN work_av4lzmkbbzda3hgvpstyfssllm 235 93 after after IN work_av4lzmkbbzda3hgvpstyfssllm 235 94 acute acute JJ work_av4lzmkbbzda3hgvpstyfssllm 235 95 attack attack NN work_av4lzmkbbzda3hgvpstyfssllm 235 96 , , , work_av4lzmkbbzda3hgvpstyfssllm 235 97 no no DT work_av4lzmkbbzda3hgvpstyfssllm 235 98 or or CC work_av4lzmkbbzda3hgvpstyfssllm 235 99 mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 235 100 developmental developmental JJ work_av4lzmkbbzda3hgvpstyfssllm 235 101 delay delay NN work_av4lzmkbbzda3hgvpstyfssllm 235 102 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 235 103 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 235 104 : : : work_av4lzmkbbzda3hgvpstyfssllm 235 105 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 235 106 in in IN work_av4lzmkbbzda3hgvpstyfssllm 235 107 infancy infancy NN work_av4lzmkbbzda3hgvpstyfssllm 235 108 , , , work_av4lzmkbbzda3hgvpstyfssllm 235 109 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 235 110 neurological neurological JJ work_av4lzmkbbzda3hgvpstyfssllm 235 111 involvement involvement NN work_av4lzmkbbzda3hgvpstyfssllm 235 112 with with IN work_av4lzmkbbzda3hgvpstyfssllm 235 113 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 235 114 developmental developmental JJ work_av4lzmkbbzda3hgvpstyfssllm 235 115 delay delay NN work_av4lzmkbbzda3hgvpstyfssllm 235 116 . . . work_av4lzmkbbzda3hgvpstyfssllm 236 1 BDetect- BDetect- NNP work_av4lzmkbbzda3hgvpstyfssllm 236 2 ed ed NNP work_av4lzmkbbzda3hgvpstyfssllm 236 3 by by IN work_av4lzmkbbzda3hgvpstyfssllm 236 4 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 236 5 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 236 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 237 1 COnly conly RB work_av4lzmkbbzda3hgvpstyfssllm 237 2 one one CD work_av4lzmkbbzda3hgvpstyfssllm 237 3 allele allele RB work_av4lzmkbbzda3hgvpstyfssllm 237 4 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 237 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 238 1 DHomozygous dhomozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 238 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 239 1 EActivates eactivate VBZ work_av4lzmkbbzda3hgvpstyfssllm 239 2 cryptic cryptic JJ work_av4lzmkbbzda3hgvpstyfssllm 239 3 splice splice NN work_av4lzmkbbzda3hgvpstyfssllm 239 4 donor donor NN work_av4lzmkbbzda3hgvpstyfssllm 239 5 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 239 6 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 239 7 5b 5b NN work_av4lzmkbbzda3hgvpstyfssllm 239 8 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 239 9 . . . work_av4lzmkbbzda3hgvpstyfssllm 240 1 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 240 2 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 240 3 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 240 4 mutant mutant NN work_av4lzmkbbzda3hgvpstyfssllm 240 5 alleles allele NNS work_av4lzmkbbzda3hgvpstyfssllm 240 6 No no UH work_av4lzmkbbzda3hgvpstyfssllm 240 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 241 1 Allele Allele NNP work_av4lzmkbbzda3hgvpstyfssllm 241 2 Exon Exon NNP work_av4lzmkbbzda3hgvpstyfssllm 241 3 Nucleotide Nucleotide NNP work_av4lzmkbbzda3hgvpstyfssllm 241 4 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 241 5 Ethnic ethnic JJ work_av4lzmkbbzda3hgvpstyfssllm 241 6 Proband Proband NNP work_av4lzmkbbzda3hgvpstyfssllm 241 7 change change NN work_av4lzmkbbzda3hgvpstyfssllm 241 8 phenotypeA phenotypeA NNP work_av4lzmkbbzda3hgvpstyfssllm 241 9 origin origin NN work_av4lzmkbbzda3hgvpstyfssllm 241 10 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 241 11 R385S r385s CD work_av4lzmkbbzda3hgvpstyfssllm 241 12 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 241 13 1155A→C 1155a→c CD work_av4lzmkbbzda3hgvpstyfssllm 241 14 Severe Severe NNP work_av4lzmkbbzda3hgvpstyfssllm 241 15 German German NNP work_av4lzmkbbzda3hgvpstyfssllm 241 16 011B 011b NN work_av4lzmkbbzda3hgvpstyfssllm 241 17 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 241 18 Q421fs(+1 q421fs(+1 NN work_av4lzmkbbzda3hgvpstyfssllm 241 19 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 241 20 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 241 21 1264insG 1264insg CD work_av4lzmkbbzda3hgvpstyfssllm 241 22 Mild Mild NNP work_av4lzmkbbzda3hgvpstyfssllm 241 23 Swedish swedish JJ work_av4lzmkbbzda3hgvpstyfssllm 241 24 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 241 25 Amer Amer NNP work_av4lzmkbbzda3hgvpstyfssllm 241 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 242 1 013C 013C NFP work_av4lzmkbbzda3hgvpstyfssllm 242 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 242 3 010B 010b CD work_av4lzmkbbzda3hgvpstyfssllm 242 4 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 242 5 A289V a289v CD work_av4lzmkbbzda3hgvpstyfssllm 242 6 8 8 CD work_av4lzmkbbzda3hgvpstyfssllm 242 7 866C→T 866c→t CD work_av4lzmkbbzda3hgvpstyfssllm 242 8 Mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 242 9 American American NNP work_av4lzmkbbzda3hgvpstyfssllm 242 10 012C 012C NNP work_av4lzmkbbzda3hgvpstyfssllm 242 11 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 242 12 D532H d532h CD work_av4lzmkbbzda3hgvpstyfssllm 242 13 13 13 CD work_av4lzmkbbzda3hgvpstyfssllm 242 14 1594G→CD 1594G→CD NNS work_av4lzmkbbzda3hgvpstyfssllm 242 15 Severe Severe NNP work_av4lzmkbbzda3hgvpstyfssllm 242 16 Turkish Turkish NNP work_av4lzmkbbzda3hgvpstyfssllm 242 17 009B 009B NNP work_av4lzmkbbzda3hgvpstyfssllm 242 18 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 242 19 L437P l437p $ work_av4lzmkbbzda3hgvpstyfssllm 242 20 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 242 21 1310T→C 1310t→c CD work_av4lzmkbbzda3hgvpstyfssllm 242 22 Severe Severe NNP work_av4lzmkbbzda3hgvpstyfssllm 242 23 Argentine Argentine NNP work_av4lzmkbbzda3hgvpstyfssllm 242 24 014B 014B . work_av4lzmkbbzda3hgvpstyfssllm 242 25 AMild amild NN work_av4lzmkbbzda3hgvpstyfssllm 242 26 : : : work_av4lzmkbbzda3hgvpstyfssllm 242 27 late late JJ work_av4lzmkbbzda3hgvpstyfssllm 242 28 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 242 29 , , , work_av4lzmkbbzda3hgvpstyfssllm 242 30 good good JJ work_av4lzmkbbzda3hgvpstyfssllm 242 31 recovery recovery NN work_av4lzmkbbzda3hgvpstyfssllm 242 32 after after IN work_av4lzmkbbzda3hgvpstyfssllm 242 33 acute acute JJ work_av4lzmkbbzda3hgvpstyfssllm 242 34 attack attack NN work_av4lzmkbbzda3hgvpstyfssllm 242 35 , , , work_av4lzmkbbzda3hgvpstyfssllm 242 36 no no DT work_av4lzmkbbzda3hgvpstyfssllm 242 37 or or CC work_av4lzmkbbzda3hgvpstyfssllm 242 38 mild mild JJ work_av4lzmkbbzda3hgvpstyfssllm 242 39 developmental developmental JJ work_av4lzmkbbzda3hgvpstyfssllm 242 40 delay delay NN work_av4lzmkbbzda3hgvpstyfssllm 242 41 ; ; : work_av4lzmkbbzda3hgvpstyfssllm 242 42 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 242 43 : : : work_av4lzmkbbzda3hgvpstyfssllm 242 44 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 242 45 in in IN work_av4lzmkbbzda3hgvpstyfssllm 242 46 infancy infancy NN work_av4lzmkbbzda3hgvpstyfssllm 242 47 , , , work_av4lzmkbbzda3hgvpstyfssllm 242 48 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 242 49 neurological neurological JJ work_av4lzmkbbzda3hgvpstyfssllm 242 50 involvement involvement NN work_av4lzmkbbzda3hgvpstyfssllm 242 51 with with IN work_av4lzmkbbzda3hgvpstyfssllm 242 52 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 242 53 developmental developmental JJ work_av4lzmkbbzda3hgvpstyfssllm 242 54 delay delay NN work_av4lzmkbbzda3hgvpstyfssllm 242 55 . . . work_av4lzmkbbzda3hgvpstyfssllm 243 1 BHomozygous bhomozygous JJ work_av4lzmkbbzda3hgvpstyfssllm 243 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 244 1 COnly conly RB work_av4lzmkbbzda3hgvpstyfssllm 244 2 one one CD work_av4lzmkbbzda3hgvpstyfssllm 244 3 allele allele RB work_av4lzmkbbzda3hgvpstyfssllm 244 4 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 244 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 245 1 DAlters dalter NNS work_av4lzmkbbzda3hgvpstyfssllm 245 2 splicing splice VBG work_av4lzmkbbzda3hgvpstyfssllm 245 3 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 245 4 Figure Figure NNP work_av4lzmkbbzda3hgvpstyfssllm 245 5 5a 5a NNP work_av4lzmkbbzda3hgvpstyfssllm 245 6 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 245 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 246 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 246 2 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 246 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 246 4 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 246 5 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 246 6 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 246 7 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 246 8 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 246 9 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 246 10 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 246 11 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 246 12 | | CD work_av4lzmkbbzda3hgvpstyfssllm 246 13 Number number NN work_av4lzmkbbzda3hgvpstyfssllm 246 14 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 246 15 503 503 CD work_av4lzmkbbzda3hgvpstyfssllm 246 16 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 246 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 246 18 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 246 19 loci loci NNP work_av4lzmkbbzda3hgvpstyfssllm 246 20 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 246 21 modifying modify VBG work_av4lzmkbbzda3hgvpstyfssllm 246 22 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 246 23 , , , work_av4lzmkbbzda3hgvpstyfssllm 246 24 environ- environ- NN work_av4lzmkbbzda3hgvpstyfssllm 246 25 mental mental JJ work_av4lzmkbbzda3hgvpstyfssllm 246 26 variables variable NNS work_av4lzmkbbzda3hgvpstyfssllm 246 27 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 246 28 must must MD work_av4lzmkbbzda3hgvpstyfssllm 246 29 have have VB work_av4lzmkbbzda3hgvpstyfssllm 246 30 a a DT work_av4lzmkbbzda3hgvpstyfssllm 246 31 major major JJ work_av4lzmkbbzda3hgvpstyfssllm 246 32 influence influence NN work_av4lzmkbbzda3hgvpstyfssllm 246 33 on on IN work_av4lzmkbbzda3hgvpstyfssllm 246 34 the the DT work_av4lzmkbbzda3hgvpstyfssllm 246 35 phenotype phenotype NN work_av4lzmkbbzda3hgvpstyfssllm 246 36 of of IN work_av4lzmkbbzda3hgvpstyfssllm 246 37 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 246 38 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 246 39 . . . work_av4lzmkbbzda3hgvpstyfssllm 247 1 Since since IN work_av4lzmkbbzda3hgvpstyfssllm 247 2 the the DT work_av4lzmkbbzda3hgvpstyfssllm 247 3 widespread widespread JJ work_av4lzmkbbzda3hgvpstyfssllm 247 4 introduction introduction NN work_av4lzmkbbzda3hgvpstyfssllm 247 5 of of IN work_av4lzmkbbzda3hgvpstyfssllm 247 6 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 247 7 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 247 8 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 247 9 to to TO work_av4lzmkbbzda3hgvpstyfssllm 247 10 new- new- VB work_av4lzmkbbzda3hgvpstyfssllm 247 11 born bear VBN work_av4lzmkbbzda3hgvpstyfssllm 247 12 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 247 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 247 14 many many JJ work_av4lzmkbbzda3hgvpstyfssllm 247 15 new new JJ work_av4lzmkbbzda3hgvpstyfssllm 247 16 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 247 17 with with IN work_av4lzmkbbzda3hgvpstyfssllm 247 18 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 247 19 defi- defi- NN work_av4lzmkbbzda3hgvpstyfssllm 247 20 ciency ciency NN work_av4lzmkbbzda3hgvpstyfssllm 247 21 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 247 22 been be VBN work_av4lzmkbbzda3hgvpstyfssllm 247 23 detected detect VBN work_av4lzmkbbzda3hgvpstyfssllm 247 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 248 1 Surprisingly surprisingly RB work_av4lzmkbbzda3hgvpstyfssllm 248 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 248 3 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 248 4 deficien- deficien- NNP work_av4lzmkbbzda3hgvpstyfssllm 248 5 cy cy NNP work_av4lzmkbbzda3hgvpstyfssllm 248 6 appears appear VBZ work_av4lzmkbbzda3hgvpstyfssllm 248 7 to to TO work_av4lzmkbbzda3hgvpstyfssllm 248 8 be be VB work_av4lzmkbbzda3hgvpstyfssllm 248 9 the the DT work_av4lzmkbbzda3hgvpstyfssllm 248 10 most most RBS work_av4lzmkbbzda3hgvpstyfssllm 248 11 frequent frequent JJ work_av4lzmkbbzda3hgvpstyfssllm 248 12 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 248 13 aciduria aciduria NN work_av4lzmkbbzda3hgvpstyfssllm 248 14 in in IN work_av4lzmkbbzda3hgvpstyfssllm 248 15 these these DT work_av4lzmkbbzda3hgvpstyfssllm 248 16 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 248 17 programs program NNS work_av4lzmkbbzda3hgvpstyfssllm 248 18 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 248 19 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 248 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 248 21 6–9 6–9 CD work_av4lzmkbbzda3hgvpstyfssllm 248 22 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 248 23 with with IN work_av4lzmkbbzda3hgvpstyfssllm 248 24 an an DT work_av4lzmkbbzda3hgvpstyfssllm 248 25 overall overall JJ work_av4lzmkbbzda3hgvpstyfssllm 248 26 fre- fre- JJ work_av4lzmkbbzda3hgvpstyfssllm 248 27 quency quency NN work_av4lzmkbbzda3hgvpstyfssllm 248 28 of of IN work_av4lzmkbbzda3hgvpstyfssllm 248 29 approximately approximately RB work_av4lzmkbbzda3hgvpstyfssllm 248 30 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 248 31 in in IN work_av4lzmkbbzda3hgvpstyfssllm 248 32 50,000 50,000 CD work_av4lzmkbbzda3hgvpstyfssllm 248 33 . . . work_av4lzmkbbzda3hgvpstyfssllm 249 1 Studies study NNS work_av4lzmkbbzda3hgvpstyfssllm 249 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 249 3 these these DT work_av4lzmkbbzda3hgvpstyfssllm 249 4 prospectively prospectively RB work_av4lzmkbbzda3hgvpstyfssllm 249 5 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 249 6 individuals individual NNS work_av4lzmkbbzda3hgvpstyfssllm 249 7 should should MD work_av4lzmkbbzda3hgvpstyfssllm 249 8 provide provide VB work_av4lzmkbbzda3hgvpstyfssllm 249 9 insight insight NN work_av4lzmkbbzda3hgvpstyfssllm 249 10 into into IN work_av4lzmkbbzda3hgvpstyfssllm 249 11 the the DT work_av4lzmkbbzda3hgvpstyfssllm 249 12 factors factor NNS work_av4lzmkbbzda3hgvpstyfssllm 249 13 that that WDT work_av4lzmkbbzda3hgvpstyfssllm 249 14 determine determine VBP work_av4lzmkbbzda3hgvpstyfssllm 249 15 the the DT work_av4lzmkbbzda3hgvpstyfssllm 249 16 phenotypic phenotypic JJ work_av4lzmkbbzda3hgvpstyfssllm 249 17 severity severity NN work_av4lzmkbbzda3hgvpstyfssllm 249 18 of of IN work_av4lzmkbbzda3hgvpstyfssllm 249 19 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 249 20 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 249 21 . . . work_av4lzmkbbzda3hgvpstyfssllm 250 1 Note note NN work_av4lzmkbbzda3hgvpstyfssllm 250 2 added add VBN work_av4lzmkbbzda3hgvpstyfssllm 250 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 250 4 proof proof NN work_av4lzmkbbzda3hgvpstyfssllm 250 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 251 1 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 251 2 have have VBP work_av4lzmkbbzda3hgvpstyfssllm 251 3 recently recently RB work_av4lzmkbbzda3hgvpstyfssllm 251 4 learned learn VBN work_av4lzmkbbzda3hgvpstyfssllm 251 5 that that IN work_av4lzmkbbzda3hgvpstyfssllm 251 6 the the DT work_av4lzmkbbzda3hgvpstyfssllm 251 7 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 251 8 basis basis NN work_av4lzmkbbzda3hgvpstyfssllm 251 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 251 10 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 251 11 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 251 12 has have VBZ work_av4lzmkbbzda3hgvpstyfssllm 251 13 also also RB work_av4lzmkbbzda3hgvpstyfssllm 251 14 been be VBN work_av4lzmkbbzda3hgvpstyfssllm 251 15 identi- identi- NN work_av4lzmkbbzda3hgvpstyfssllm 251 16 fied fie VBN work_av4lzmkbbzda3hgvpstyfssllm 251 17 by by IN work_av4lzmkbbzda3hgvpstyfssllm 251 18 Gallardo Gallardo NNP work_av4lzmkbbzda3hgvpstyfssllm 251 19 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 251 20 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 251 21 . . . work_av4lzmkbbzda3hgvpstyfssllm 252 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 252 2 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 252 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 252 4 Am Am NNP work_av4lzmkbbzda3hgvpstyfssllm 252 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 253 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 253 2 Hum Hum NNP work_av4lzmkbbzda3hgvpstyfssllm 253 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 254 1 Genet Genet NNP work_av4lzmkbbzda3hgvpstyfssllm 254 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 255 1 68:334 68:334 CD work_av4lzmkbbzda3hgvpstyfssllm 255 2 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 255 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 256 1 Acknowledgments acknowledgment NNS work_av4lzmkbbzda3hgvpstyfssllm 256 2 We -PRON- PRP work_av4lzmkbbzda3hgvpstyfssllm 256 3 thank thank VBP work_av4lzmkbbzda3hgvpstyfssllm 256 4 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 256 5 Kohlschütter Kohlschütter NNP work_av4lzmkbbzda3hgvpstyfssllm 256 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 256 7 U. U. NNP work_av4lzmkbbzda3hgvpstyfssllm 256 8 von von NNP work_av4lzmkbbzda3hgvpstyfssllm 256 9 Döbeln Döbeln NNP work_av4lzmkbbzda3hgvpstyfssllm 256 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 256 11 S. S. NNP work_av4lzmkbbzda3hgvpstyfssllm 256 12 Berry Berry NNP work_av4lzmkbbzda3hgvpstyfssllm 256 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 256 14 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 256 15 Smeitink Smeitink NNP work_av4lzmkbbzda3hgvpstyfssllm 256 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 256 17 R.D. R.D. NNP work_av4lzmkbbzda3hgvpstyfssllm 257 1 De De NNP work_av4lzmkbbzda3hgvpstyfssllm 257 2 Kremer Kremer NNP work_av4lzmkbbzda3hgvpstyfssllm 257 3 Dodelson Dodelson NNP work_av4lzmkbbzda3hgvpstyfssllm 257 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 257 5 W. W. NNP work_av4lzmkbbzda3hgvpstyfssllm 257 6 Lehnert Lehnert NNP work_av4lzmkbbzda3hgvpstyfssllm 257 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 257 8 U. U. NNP work_av4lzmkbbzda3hgvpstyfssllm 257 9 Wiesmann Wiesmann NNP work_av4lzmkbbzda3hgvpstyfssllm 257 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 257 11 U. U. NNP work_av4lzmkbbzda3hgvpstyfssllm 257 12 Wendel Wendel NNP work_av4lzmkbbzda3hgvpstyfssllm 257 13 , , , work_av4lzmkbbzda3hgvpstyfssllm 257 14 W.J. W.J. NNP work_av4lzmkbbzda3hgvpstyfssllm 258 1 Kleijer Kleijer NNP work_av4lzmkbbzda3hgvpstyfssllm 258 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 258 3 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 258 4 Steinmann Steinmann NNP work_av4lzmkbbzda3hgvpstyfssllm 258 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 258 6 B.T. B.T. NNP work_av4lzmkbbzda3hgvpstyfssllm 259 1 Poll Poll NNP work_av4lzmkbbzda3hgvpstyfssllm 259 2 - - . work_av4lzmkbbzda3hgvpstyfssllm 259 3 The the DT work_av4lzmkbbzda3hgvpstyfssllm 259 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 259 5 D.H. D.H. NNP work_av4lzmkbbzda3hgvpstyfssllm 259 6 Morton Morton NNP work_av4lzmkbbzda3hgvpstyfssllm 259 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 259 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 259 9 H.G H.G NNP work_av4lzmkbbzda3hgvpstyfssllm 259 10 Koch Koch NNP work_av4lzmkbbzda3hgvpstyfssllm 259 11 for for IN work_av4lzmkbbzda3hgvpstyfssllm 259 12 referring refer VBG work_av4lzmkbbzda3hgvpstyfssllm 259 13 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 259 14 of of IN work_av4lzmkbbzda3hgvpstyfssllm 259 15 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 259 16 patients patient NNS work_av4lzmkbbzda3hgvpstyfssllm 259 17 , , , work_av4lzmkbbzda3hgvpstyfssllm 259 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 259 19 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 259 20 Nathans Nathans NNP work_av4lzmkbbzda3hgvpstyfssllm 259 21 for for IN work_av4lzmkbbzda3hgvpstyfssllm 259 22 provid- provid- NN work_av4lzmkbbzda3hgvpstyfssllm 259 23 ing e VBG work_av4lzmkbbzda3hgvpstyfssllm 259 24 the the DT work_av4lzmkbbzda3hgvpstyfssllm 259 25 human human NNP work_av4lzmkbbzda3hgvpstyfssllm 259 26 retina retina NNP work_av4lzmkbbzda3hgvpstyfssllm 259 27 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 259 28 library library NNP work_av4lzmkbbzda3hgvpstyfssllm 259 29 and and CC work_av4lzmkbbzda3hgvpstyfssllm 259 30 S. S. NNP work_av4lzmkbbzda3hgvpstyfssllm 259 31 Muscelli Muscelli NNP work_av4lzmkbbzda3hgvpstyfssllm 259 32 for for IN work_av4lzmkbbzda3hgvpstyfssllm 259 33 assistance assistance NN work_av4lzmkbbzda3hgvpstyfssllm 259 34 in in IN work_av4lzmkbbzda3hgvpstyfssllm 259 35 preparing prepare VBG work_av4lzmkbbzda3hgvpstyfssllm 259 36 the the DT work_av4lzmkbbzda3hgvpstyfssllm 259 37 manuscript manuscript NN work_av4lzmkbbzda3hgvpstyfssllm 259 38 . . . work_av4lzmkbbzda3hgvpstyfssllm 260 1 M.R. M.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 261 1 Baum- Baum- NNP work_av4lzmkbbzda3hgvpstyfssllm 261 2 gartner gartner NN work_av4lzmkbbzda3hgvpstyfssllm 261 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 261 4 T. T. NNP work_av4lzmkbbzda3hgvpstyfssllm 261 5 Suormala Suormala NNP work_av4lzmkbbzda3hgvpstyfssllm 261 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 261 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 261 8 E.R. E.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 262 1 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 262 2 are be VBP work_av4lzmkbbzda3hgvpstyfssllm 262 3 sup- sup- RB work_av4lzmkbbzda3hgvpstyfssllm 262 4 ported port VBN work_av4lzmkbbzda3hgvpstyfssllm 262 5 by by IN work_av4lzmkbbzda3hgvpstyfssllm 262 6 grants grant NNS work_av4lzmkbbzda3hgvpstyfssllm 262 7 from from IN work_av4lzmkbbzda3hgvpstyfssllm 262 8 the the DT work_av4lzmkbbzda3hgvpstyfssllm 262 9 Swiss Swiss NNP work_av4lzmkbbzda3hgvpstyfssllm 262 10 National National NNP work_av4lzmkbbzda3hgvpstyfssllm 262 11 Science Science NNP work_av4lzmkbbzda3hgvpstyfssllm 262 12 foun- foun- JJ work_av4lzmkbbzda3hgvpstyfssllm 262 13 dation dation NN work_av4lzmkbbzda3hgvpstyfssllm 262 14 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 262 15 32 32 CD work_av4lzmkbbzda3hgvpstyfssllm 262 16 - - SYM work_av4lzmkbbzda3hgvpstyfssllm 262 17 40898.94 40898.94 CD work_av4lzmkbbzda3hgvpstyfssllm 262 18 for for IN work_av4lzmkbbzda3hgvpstyfssllm 262 19 T. T. NNP work_av4lzmkbbzda3hgvpstyfssllm 262 20 Suormala Suormala NNP work_av4lzmkbbzda3hgvpstyfssllm 262 21 and and CC work_av4lzmkbbzda3hgvpstyfssllm 262 22 E.R. E.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 263 1 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 263 2 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 263 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 264 1 R.N. R.N. NNP work_av4lzmkbbzda3hgvpstyfssllm 265 1 Cole Cole NNP work_av4lzmkbbzda3hgvpstyfssllm 265 2 was be VBD work_av4lzmkbbzda3hgvpstyfssllm 265 3 supported support VBN work_av4lzmkbbzda3hgvpstyfssllm 265 4 by by IN work_av4lzmkbbzda3hgvpstyfssllm 265 5 the the DT work_av4lzmkbbzda3hgvpstyfssllm 265 6 Ameri- Ameri- NNP work_av4lzmkbbzda3hgvpstyfssllm 265 7 can can MD work_av4lzmkbbzda3hgvpstyfssllm 265 8 Health Health NNP work_av4lzmkbbzda3hgvpstyfssllm 265 9 Foundation Foundation NNP work_av4lzmkbbzda3hgvpstyfssllm 265 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 266 1 D. D. NNP work_av4lzmkbbzda3hgvpstyfssllm 266 2 Valle Valle NNP work_av4lzmkbbzda3hgvpstyfssllm 266 3 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 266 4 an an DT work_av4lzmkbbzda3hgvpstyfssllm 266 5 Investigator Investigator NNP work_av4lzmkbbzda3hgvpstyfssllm 266 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 266 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 266 8 Howard Howard NNP work_av4lzmkbbzda3hgvpstyfssllm 266 9 Hughes Hughes NNP work_av4lzmkbbzda3hgvpstyfssllm 266 10 Medical Medical NNP work_av4lzmkbbzda3hgvpstyfssllm 266 11 Institute Institute NNP work_av4lzmkbbzda3hgvpstyfssllm 266 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 267 1 1 1 LS work_av4lzmkbbzda3hgvpstyfssllm 267 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 268 1 Sweetman Sweetman NNP work_av4lzmkbbzda3hgvpstyfssllm 268 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 268 3 L. L. NNP work_av4lzmkbbzda3hgvpstyfssllm 268 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 268 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 268 6 Williams Williams NNP work_av4lzmkbbzda3hgvpstyfssllm 268 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 268 8 J.C. J.C. NNP work_av4lzmkbbzda3hgvpstyfssllm 268 9 1995 1995 CD work_av4lzmkbbzda3hgvpstyfssllm 268 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 269 1 Branched branched JJ work_av4lzmkbbzda3hgvpstyfssllm 269 2 chain chain NN work_av4lzmkbbzda3hgvpstyfssllm 269 3 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 269 4 acidurias acidurias NNP work_av4lzmkbbzda3hgvpstyfssllm 269 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 270 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 270 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 270 3 metabolic metabolic JJ work_av4lzmkbbzda3hgvpstyfssllm 270 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 270 5 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 270 6 bases basis NNS work_av4lzmkbbzda3hgvpstyfssllm 270 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 270 8 inherited inherit VBN work_av4lzmkbbzda3hgvpstyfssllm 270 9 disease disease NN work_av4lzmkbbzda3hgvpstyfssllm 270 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 271 1 7th 7th JJ work_av4lzmkbbzda3hgvpstyfssllm 271 2 edition edition NNP work_av4lzmkbbzda3hgvpstyfssllm 271 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 272 1 C.R. C.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 273 1 Scriver Scriver NNP work_av4lzmkbbzda3hgvpstyfssllm 273 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 273 3 A.L. A.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 274 1 Beaudet Beaudet NNP work_av4lzmkbbzda3hgvpstyfssllm 274 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 274 3 W.S. W.S. NNP work_av4lzmkbbzda3hgvpstyfssllm 275 1 Sly Sly NNP work_av4lzmkbbzda3hgvpstyfssllm 275 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 275 3 and and CC work_av4lzmkbbzda3hgvpstyfssllm 275 4 D. D. NNP work_av4lzmkbbzda3hgvpstyfssllm 275 5 Valle Valle NNP work_av4lzmkbbzda3hgvpstyfssllm 275 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 275 7 editors editor NNS work_av4lzmkbbzda3hgvpstyfssllm 275 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 276 1 McGraw McGraw NNP work_av4lzmkbbzda3hgvpstyfssllm 276 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 276 3 Hill Hill NNP work_av4lzmkbbzda3hgvpstyfssllm 276 4 . . . work_av4lzmkbbzda3hgvpstyfssllm 277 1 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 277 2 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 277 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 277 4 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 277 5 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 277 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 277 7 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 277 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 278 1 1387–1422 1387–1422 CD work_av4lzmkbbzda3hgvpstyfssllm 278 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 279 1 2 2 LS work_av4lzmkbbzda3hgvpstyfssllm 279 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 280 1 Bannwart Bannwart NNP work_av4lzmkbbzda3hgvpstyfssllm 280 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 3 C. C. NNP work_av4lzmkbbzda3hgvpstyfssllm 280 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 5 Wermuth Wermuth NNP work_av4lzmkbbzda3hgvpstyfssllm 280 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 7 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 280 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 9 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 280 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 11 R. R. NNP work_av4lzmkbbzda3hgvpstyfssllm 280 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 13 Suormala Suormala NNP work_av4lzmkbbzda3hgvpstyfssllm 280 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 15 T. T. NNP work_av4lzmkbbzda3hgvpstyfssllm 280 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 280 18 Weis- Weis- NNP work_av4lzmkbbzda3hgvpstyfssllm 280 19 mann mann NNP work_av4lzmkbbzda3hgvpstyfssllm 280 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 280 21 U.N. U.N. NNP work_av4lzmkbbzda3hgvpstyfssllm 280 22 1992 1992 CD work_av4lzmkbbzda3hgvpstyfssllm 280 23 . . . work_av4lzmkbbzda3hgvpstyfssllm 281 1 Isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 281 2 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 281 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 281 4 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 281 5 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 281 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 281 7 3-methyl- 3-methyl- NNP work_av4lzmkbbzda3hgvpstyfssllm 281 8 crotonyl crotonyl NNP work_av4lzmkbbzda3hgvpstyfssllm 281 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 281 10 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 281 11 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 281 12 presenting present VBG work_av4lzmkbbzda3hgvpstyfssllm 281 13 as as IN work_av4lzmkbbzda3hgvpstyfssllm 281 14 a a DT work_av4lzmkbbzda3hgvpstyfssllm 281 15 clinically clinically RB work_av4lzmkbbzda3hgvpstyfssllm 281 16 severe severe JJ work_av4lzmkbbzda3hgvpstyfssllm 281 17 form form NN work_av4lzmkbbzda3hgvpstyfssllm 281 18 in in IN work_av4lzmkbbzda3hgvpstyfssllm 281 19 a a DT work_av4lzmkbbzda3hgvpstyfssllm 281 20 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 281 21 with with IN work_av4lzmkbbzda3hgvpstyfssllm 281 22 fatal fatal JJ work_av4lzmkbbzda3hgvpstyfssllm 281 23 outcome outcome NN work_av4lzmkbbzda3hgvpstyfssllm 281 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 282 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 283 1 Inherit inherit NN work_av4lzmkbbzda3hgvpstyfssllm 283 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 284 1 Metab Metab NNP work_av4lzmkbbzda3hgvpstyfssllm 284 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 285 1 Dis Dis NNP work_av4lzmkbbzda3hgvpstyfssllm 285 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 286 1 15:863–868 15:863–868 CD work_av4lzmkbbzda3hgvpstyfssllm 286 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 287 1 3 3 LS work_av4lzmkbbzda3hgvpstyfssllm 287 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 288 1 Lehnert Lehnert NNP work_av4lzmkbbzda3hgvpstyfssllm 288 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 3 W. W. NNP work_av4lzmkbbzda3hgvpstyfssllm 288 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 5 Niederhoff Niederhoff NNP work_av4lzmkbbzda3hgvpstyfssllm 288 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 7 H. H. NNP work_av4lzmkbbzda3hgvpstyfssllm 288 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 9 Suormala Suormala NNP work_av4lzmkbbzda3hgvpstyfssllm 288 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 11 T. T. NNP work_av4lzmkbbzda3hgvpstyfssllm 288 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 288 14 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 288 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 288 16 E.R. E.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 289 1 1996 1996 CD work_av4lzmkbbzda3hgvpstyfssllm 289 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 290 1 Isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 290 2 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 290 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 290 4 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 290 5 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 290 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 290 7 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 290 8 carboxylase carboxylase NNP work_av4lzmkbbzda3hgvpstyfssllm 290 9 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 290 10 : : : work_av4lzmkbbzda3hgvpstyfssllm 290 11 long long JJ work_av4lzmkbbzda3hgvpstyfssllm 290 12 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 290 13 term term NN work_av4lzmkbbzda3hgvpstyfssllm 290 14 outcome outcome NN work_av4lzmkbbzda3hgvpstyfssllm 290 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 290 16 a a DT work_av4lzmkbbzda3hgvpstyfssllm 290 17 case case NN work_av4lzmkbbzda3hgvpstyfssllm 290 18 with with IN work_av4lzmkbbzda3hgvpstyfssllm 290 19 neonatal neonatal JJ work_av4lzmkbbzda3hgvpstyfssllm 290 20 onset onset NN work_av4lzmkbbzda3hgvpstyfssllm 290 21 . . . work_av4lzmkbbzda3hgvpstyfssllm 291 1 Eur Eur NNP work_av4lzmkbbzda3hgvpstyfssllm 291 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 292 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 292 2 Pediatr Pediatr NNP work_av4lzmkbbzda3hgvpstyfssllm 292 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 293 1 155:568–572 155:568–572 LS work_av4lzmkbbzda3hgvpstyfssllm 293 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 294 1 4 4 LS work_av4lzmkbbzda3hgvpstyfssllm 294 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 295 1 Gibson Gibson NNP work_av4lzmkbbzda3hgvpstyfssllm 295 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 3 K.M. K.M. NNP work_av4lzmkbbzda3hgvpstyfssllm 295 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 5 Bennett Bennett NNP work_av4lzmkbbzda3hgvpstyfssllm 295 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 7 M.J. M.J. NNP work_av4lzmkbbzda3hgvpstyfssllm 295 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 9 Naylor Naylor NNP work_av4lzmkbbzda3hgvpstyfssllm 295 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 11 E.W. E.W. NNP work_av4lzmkbbzda3hgvpstyfssllm 295 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 295 14 Morton Morton NNP work_av4lzmkbbzda3hgvpstyfssllm 295 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 295 16 D.H. D.H. NNP work_av4lzmkbbzda3hgvpstyfssllm 295 17 1998 1998 CD work_av4lzmkbbzda3hgvpstyfssllm 295 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 296 1 3- 3- LS work_av4lzmkbbzda3hgvpstyfssllm 296 2 Methylcrotonyl Methylcrotonyl NNP work_av4lzmkbbzda3hgvpstyfssllm 296 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 296 4 coenzyme coenzyme VBZ work_av4lzmkbbzda3hgvpstyfssllm 296 5 A a DT work_av4lzmkbbzda3hgvpstyfssllm 296 6 carboxylase carboxylase JJ work_av4lzmkbbzda3hgvpstyfssllm 296 7 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 296 8 in in IN work_av4lzmkbbzda3hgvpstyfssllm 296 9 Amish Amish NNP work_av4lzmkbbzda3hgvpstyfssllm 296 10 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 296 11 Men- Men- NNP work_av4lzmkbbzda3hgvpstyfssllm 296 12 nonite nonite NN work_av4lzmkbbzda3hgvpstyfssllm 296 13 adults adult NNS work_av4lzmkbbzda3hgvpstyfssllm 296 14 identified identify VBN work_av4lzmkbbzda3hgvpstyfssllm 296 15 by by IN work_av4lzmkbbzda3hgvpstyfssllm 296 16 detection detection NN work_av4lzmkbbzda3hgvpstyfssllm 296 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 296 18 increased increase VBN work_av4lzmkbbzda3hgvpstyfssllm 296 19 acylcarnitines acylcarnitine NNS work_av4lzmkbbzda3hgvpstyfssllm 296 20 in in IN work_av4lzmkbbzda3hgvpstyfssllm 296 21 blood blood NN work_av4lzmkbbzda3hgvpstyfssllm 296 22 spots spot NNS work_av4lzmkbbzda3hgvpstyfssllm 296 23 of of IN work_av4lzmkbbzda3hgvpstyfssllm 296 24 their -PRON- PRP$ work_av4lzmkbbzda3hgvpstyfssllm 296 25 children child NNS work_av4lzmkbbzda3hgvpstyfssllm 296 26 . . . work_av4lzmkbbzda3hgvpstyfssllm 297 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 297 2 Pediatr Pediatr NNP work_av4lzmkbbzda3hgvpstyfssllm 297 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 298 1 132:519–523 132:519–523 LS work_av4lzmkbbzda3hgvpstyfssllm 298 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 299 1 5 5 CD work_av4lzmkbbzda3hgvpstyfssllm 299 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 300 1 Levy levy UH work_av4lzmkbbzda3hgvpstyfssllm 300 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 300 3 H.L. H.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 301 1 1998 1998 CD work_av4lzmkbbzda3hgvpstyfssllm 301 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 302 1 Newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 302 2 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 302 3 by by IN work_av4lzmkbbzda3hgvpstyfssllm 302 4 tandem tandem NNP work_av4lzmkbbzda3hgvpstyfssllm 302 5 mass mass NNP work_av4lzmkbbzda3hgvpstyfssllm 302 6 spectrometry spectrometry NNP work_av4lzmkbbzda3hgvpstyfssllm 302 7 : : : work_av4lzmkbbzda3hgvpstyfssllm 302 8 a a DT work_av4lzmkbbzda3hgvpstyfssllm 302 9 new new JJ work_av4lzmkbbzda3hgvpstyfssllm 302 10 era era NN work_av4lzmkbbzda3hgvpstyfssllm 302 11 . . . work_av4lzmkbbzda3hgvpstyfssllm 303 1 Clin Clin NNP work_av4lzmkbbzda3hgvpstyfssllm 303 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 304 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 304 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 305 1 44:2401–2402 44:2401–2402 CD work_av4lzmkbbzda3hgvpstyfssllm 305 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 306 1 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 306 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 307 1 Naylor Naylor NNP work_av4lzmkbbzda3hgvpstyfssllm 307 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 307 3 E.W. E.W. NNP work_av4lzmkbbzda3hgvpstyfssllm 307 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 307 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 307 6 Chace Chace NNP work_av4lzmkbbzda3hgvpstyfssllm 307 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 307 8 D.H. D.H. NNP work_av4lzmkbbzda3hgvpstyfssllm 307 9 1999 1999 CD work_av4lzmkbbzda3hgvpstyfssllm 307 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 308 1 Automated automate VBN work_av4lzmkbbzda3hgvpstyfssllm 308 2 tandem tandem JJ work_av4lzmkbbzda3hgvpstyfssllm 308 3 mass mass JJ work_av4lzmkbbzda3hgvpstyfssllm 308 4 spec- spec- NN work_av4lzmkbbzda3hgvpstyfssllm 308 5 trometry trometry NN work_av4lzmkbbzda3hgvpstyfssllm 308 6 for for IN work_av4lzmkbbzda3hgvpstyfssllm 308 7 mass mass JJ work_av4lzmkbbzda3hgvpstyfssllm 308 8 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 308 9 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 308 10 for for IN work_av4lzmkbbzda3hgvpstyfssllm 308 11 disorders disorder NNS work_av4lzmkbbzda3hgvpstyfssllm 308 12 in in IN work_av4lzmkbbzda3hgvpstyfssllm 308 13 fatty fatty NN work_av4lzmkbbzda3hgvpstyfssllm 308 14 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 308 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 308 16 organic organic JJ work_av4lzmkbbzda3hgvpstyfssllm 308 17 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 308 18 and and CC work_av4lzmkbbzda3hgvpstyfssllm 308 19 amino amino NN work_av4lzmkbbzda3hgvpstyfssllm 308 20 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 308 21 metabolism metabolism NN work_av4lzmkbbzda3hgvpstyfssllm 308 22 . . . work_av4lzmkbbzda3hgvpstyfssllm 309 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 310 1 Child Child NNP work_av4lzmkbbzda3hgvpstyfssllm 310 2 Neurol Neurol NNP work_av4lzmkbbzda3hgvpstyfssllm 310 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 311 1 14(Suppl 14(suppl ADD work_av4lzmkbbzda3hgvpstyfssllm 311 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 312 1 1):S4–S8 1):S4–S8 NNP work_av4lzmkbbzda3hgvpstyfssllm 312 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 313 1 7 7 LS work_av4lzmkbbzda3hgvpstyfssllm 313 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 314 1 Smith Smith NNP work_av4lzmkbbzda3hgvpstyfssllm 314 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 314 3 W.E. W.E. NNP work_av4lzmkbbzda3hgvpstyfssllm 314 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 314 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 314 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 314 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 315 1 2000 2000 CD work_av4lzmkbbzda3hgvpstyfssllm 315 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 316 1 Evaluation evaluation NN work_av4lzmkbbzda3hgvpstyfssllm 316 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 316 3 elevated elevated JJ work_av4lzmkbbzda3hgvpstyfssllm 316 4 hydroxyisovaleryl- hydroxyisovaleryl- NN work_av4lzmkbbzda3hgvpstyfssllm 316 5 carnitine carnitine NN work_av4lzmkbbzda3hgvpstyfssllm 316 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 316 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 316 8 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 316 9 screen screen NN work_av4lzmkbbzda3hgvpstyfssllm 316 10 by by IN work_av4lzmkbbzda3hgvpstyfssllm 316 11 tandem tandem NNP work_av4lzmkbbzda3hgvpstyfssllm 316 12 mass mass NNP work_av4lzmkbbzda3hgvpstyfssllm 316 13 spectrometry spectrometry NNP work_av4lzmkbbzda3hgvpstyfssllm 316 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 317 1 Am Am NNP work_av4lzmkbbzda3hgvpstyfssllm 317 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 318 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 318 2 Hum Hum NNP work_av4lzmkbbzda3hgvpstyfssllm 318 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 319 1 Genet Genet NNP work_av4lzmkbbzda3hgvpstyfssllm 319 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 320 1 67:292 67:292 CD work_av4lzmkbbzda3hgvpstyfssllm 320 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 321 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 321 2 Abstr Abstr NNP work_av4lzmkbbzda3hgvpstyfssllm 321 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 321 4 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 322 1 8 8 LS work_av4lzmkbbzda3hgvpstyfssllm 322 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 323 1 Roscher Roscher NNP work_av4lzmkbbzda3hgvpstyfssllm 323 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 3 A.A. A.A. NNP work_av4lzmkbbzda3hgvpstyfssllm 323 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 5 Liebl Liebl NNP work_av4lzmkbbzda3hgvpstyfssllm 323 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 7 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 323 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 9 Fingerhut Fingerhut NNP work_av4lzmkbbzda3hgvpstyfssllm 323 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 11 R. R. NNP work_av4lzmkbbzda3hgvpstyfssllm 323 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 323 14 Olgemöller Olgemöller NNP work_av4lzmkbbzda3hgvpstyfssllm 323 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 323 16 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 324 1 2000 2000 CD work_av4lzmkbbzda3hgvpstyfssllm 324 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 325 1 Prospective prospective JJ work_av4lzmkbbzda3hgvpstyfssllm 325 2 study study NN work_av4lzmkbbzda3hgvpstyfssllm 325 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 325 4 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 325 5 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 325 6 MS MS NNP work_av4lzmkbbzda3hgvpstyfssllm 325 7 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 325 8 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 325 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 325 10 Bavaria Bavaria NNP work_av4lzmkbbzda3hgvpstyfssllm 325 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 325 12 Germany Germany NNP work_av4lzmkbbzda3hgvpstyfssllm 325 13 . . . work_av4lzmkbbzda3hgvpstyfssllm 326 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 327 1 Inherit inherit NN work_av4lzmkbbzda3hgvpstyfssllm 327 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 328 1 Metab Metab NNP work_av4lzmkbbzda3hgvpstyfssllm 328 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 329 1 Dis Dis NNP work_av4lzmkbbzda3hgvpstyfssllm 329 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 330 1 23:4 23:4 CD work_av4lzmkbbzda3hgvpstyfssllm 330 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 331 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 331 2 Abstr Abstr NNP work_av4lzmkbbzda3hgvpstyfssllm 331 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 331 4 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 332 1 9 9 CD work_av4lzmkbbzda3hgvpstyfssllm 332 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 333 1 Wilcken Wilcken NNP work_av4lzmkbbzda3hgvpstyfssllm 333 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 333 3 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 333 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 333 5 Wiley Wiley NNP work_av4lzmkbbzda3hgvpstyfssllm 333 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 333 7 V. V. NNP work_av4lzmkbbzda3hgvpstyfssllm 333 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 333 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 333 10 Carpenter Carpenter NNP work_av4lzmkbbzda3hgvpstyfssllm 333 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 333 12 K. K. NNP work_av4lzmkbbzda3hgvpstyfssllm 333 13 2000 2000 CD work_av4lzmkbbzda3hgvpstyfssllm 333 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 334 1 Two two CD work_av4lzmkbbzda3hgvpstyfssllm 334 2 years year NNS work_av4lzmkbbzda3hgvpstyfssllm 334 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 334 4 routine routine JJ work_av4lzmkbbzda3hgvpstyfssllm 334 5 newborn newborn JJ work_av4lzmkbbzda3hgvpstyfssllm 334 6 screening screening NN work_av4lzmkbbzda3hgvpstyfssllm 334 7 by by IN work_av4lzmkbbzda3hgvpstyfssllm 334 8 tandem tandem NNP work_av4lzmkbbzda3hgvpstyfssllm 334 9 mass mass NNP work_av4lzmkbbzda3hgvpstyfssllm 334 10 spectrometry spectrometry NNP work_av4lzmkbbzda3hgvpstyfssllm 334 11 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 334 12 MSMS MSMS NNP work_av4lzmkbbzda3hgvpstyfssllm 334 13 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 334 14 in in IN work_av4lzmkbbzda3hgvpstyfssllm 334 15 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 334 16 South South NNP work_av4lzmkbbzda3hgvpstyfssllm 334 17 Wales Wales NNP work_av4lzmkbbzda3hgvpstyfssllm 334 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 334 19 Australia Australia NNP work_av4lzmkbbzda3hgvpstyfssllm 334 20 . . . work_av4lzmkbbzda3hgvpstyfssllm 335 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 336 1 Inherit inherit NN work_av4lzmkbbzda3hgvpstyfssllm 336 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 337 1 Metab Metab NNP work_av4lzmkbbzda3hgvpstyfssllm 337 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 338 1 Dis Dis NNP work_av4lzmkbbzda3hgvpstyfssllm 338 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 339 1 23:4 23:4 CD work_av4lzmkbbzda3hgvpstyfssllm 339 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 340 1 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 340 2 Abstr Abstr NNP work_av4lzmkbbzda3hgvpstyfssllm 340 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 340 4 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 341 1 10 10 CD work_av4lzmkbbzda3hgvpstyfssllm 341 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 342 1 Samols Samols NNP work_av4lzmkbbzda3hgvpstyfssllm 342 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 342 3 D. D. NNP work_av4lzmkbbzda3hgvpstyfssllm 342 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 342 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 342 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 342 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 343 1 1988 1988 CD work_av4lzmkbbzda3hgvpstyfssllm 343 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 344 1 Evolutionary evolutionary JJ work_av4lzmkbbzda3hgvpstyfssllm 344 2 conservation conservation NN work_av4lzmkbbzda3hgvpstyfssllm 344 3 among among IN work_av4lzmkbbzda3hgvpstyfssllm 344 4 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 344 5 enzymes enzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 344 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 345 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 345 2 Biol Biol NNP work_av4lzmkbbzda3hgvpstyfssllm 345 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 346 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 346 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 347 1 263:6461–6464 263:6461–6464 LS work_av4lzmkbbzda3hgvpstyfssllm 347 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 348 1 11 11 CD work_av4lzmkbbzda3hgvpstyfssllm 348 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 349 1 Wolf Wolf NNP work_av4lzmkbbzda3hgvpstyfssllm 349 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 349 3 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 350 1 1995 1995 CD work_av4lzmkbbzda3hgvpstyfssllm 350 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 351 1 Disorders disorder NNS work_av4lzmkbbzda3hgvpstyfssllm 351 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 351 3 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 351 4 metabolism metabolism NN work_av4lzmkbbzda3hgvpstyfssllm 351 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 352 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 352 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 352 3 metabolic metabolic JJ work_av4lzmkbbzda3hgvpstyfssllm 352 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 352 5 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 352 6 bases basis NNS work_av4lzmkbbzda3hgvpstyfssllm 352 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 352 8 inherited inherit VBN work_av4lzmkbbzda3hgvpstyfssllm 352 9 disease disease NN work_av4lzmkbbzda3hgvpstyfssllm 352 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 353 1 7th 7th JJ work_av4lzmkbbzda3hgvpstyfssllm 353 2 edition edition NNP work_av4lzmkbbzda3hgvpstyfssllm 353 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 354 1 C.R. C.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 355 1 Scriver Scriver NNP work_av4lzmkbbzda3hgvpstyfssllm 355 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 355 3 A.L. A.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 356 1 Beaudet Beaudet NNP work_av4lzmkbbzda3hgvpstyfssllm 356 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 356 3 W.S. W.S. NNP work_av4lzmkbbzda3hgvpstyfssllm 357 1 Sly Sly NNP work_av4lzmkbbzda3hgvpstyfssllm 357 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 357 3 and and CC work_av4lzmkbbzda3hgvpstyfssllm 357 4 D. D. NNP work_av4lzmkbbzda3hgvpstyfssllm 357 5 Valle Valle NNP work_av4lzmkbbzda3hgvpstyfssllm 357 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 357 7 editors editor NNS work_av4lzmkbbzda3hgvpstyfssllm 357 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 358 1 McGraw McGraw NNP work_av4lzmkbbzda3hgvpstyfssllm 358 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 358 3 Hill Hill NNP work_av4lzmkbbzda3hgvpstyfssllm 358 4 . . . work_av4lzmkbbzda3hgvpstyfssllm 359 1 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 359 2 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 359 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 359 4 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 359 5 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 359 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 359 7 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 359 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 360 1 3151–3177 3151–3177 UH work_av4lzmkbbzda3hgvpstyfssllm 360 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 361 1 12 12 CD work_av4lzmkbbzda3hgvpstyfssllm 361 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 362 1 Jitrapakdee Jitrapakdee NNP work_av4lzmkbbzda3hgvpstyfssllm 362 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 362 3 S. S. NNP work_av4lzmkbbzda3hgvpstyfssllm 362 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 362 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 362 6 Wallace Wallace NNP work_av4lzmkbbzda3hgvpstyfssllm 362 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 362 8 J.C. J.C. NNP work_av4lzmkbbzda3hgvpstyfssllm 362 9 1999 1999 CD work_av4lzmkbbzda3hgvpstyfssllm 362 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 363 1 Structure structure NN work_av4lzmkbbzda3hgvpstyfssllm 363 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 363 3 function function NN work_av4lzmkbbzda3hgvpstyfssllm 363 4 and and CC work_av4lzmkbbzda3hgvpstyfssllm 363 5 regu- regu- JJ work_av4lzmkbbzda3hgvpstyfssllm 363 6 lation lation NN work_av4lzmkbbzda3hgvpstyfssllm 363 7 of of IN work_av4lzmkbbzda3hgvpstyfssllm 363 8 pyruvate pyruvate JJ work_av4lzmkbbzda3hgvpstyfssllm 363 9 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 363 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 364 1 Biochem Biochem NNP work_av4lzmkbbzda3hgvpstyfssllm 364 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 365 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 366 1 340:1–16 340:1–16 CD work_av4lzmkbbzda3hgvpstyfssllm 366 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 367 1 13 13 CD work_av4lzmkbbzda3hgvpstyfssllm 367 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 368 1 Lamhonwah Lamhonwah NNP work_av4lzmkbbzda3hgvpstyfssllm 368 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 368 3 A.-M. A.-M. NNP work_av4lzmkbbzda3hgvpstyfssllm 368 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 368 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 368 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 368 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 369 1 1986 1986 CD work_av4lzmkbbzda3hgvpstyfssllm 369 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 370 1 Isolation isolation NN work_av4lzmkbbzda3hgvpstyfssllm 370 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 370 3 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 370 4 clones clone NNS work_av4lzmkbbzda3hgvpstyfssllm 370 5 coding code VBG work_av4lzmkbbzda3hgvpstyfssllm 370 6 for for IN work_av4lzmkbbzda3hgvpstyfssllm 370 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 370 8 a a NN work_av4lzmkbbzda3hgvpstyfssllm 370 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 370 10 b b NN work_av4lzmkbbzda3hgvpstyfssllm 370 11 chains chain NNS work_av4lzmkbbzda3hgvpstyfssllm 370 12 of of IN work_av4lzmkbbzda3hgvpstyfssllm 370 13 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 370 14 propionyl propionyl NN work_av4lzmkbbzda3hgvpstyfssllm 370 15 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 370 16 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 370 17 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 370 18 : : : work_av4lzmkbbzda3hgvpstyfssllm 370 19 chromoso- chromoso- NNP work_av4lzmkbbzda3hgvpstyfssllm 370 20 mal mal NNP work_av4lzmkbbzda3hgvpstyfssllm 370 21 assignments assignment NNS work_av4lzmkbbzda3hgvpstyfssllm 370 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 370 23 DNA dna NN work_av4lzmkbbzda3hgvpstyfssllm 370 24 polymorphisms polymorphism NNS work_av4lzmkbbzda3hgvpstyfssllm 370 25 associated associate VBN work_av4lzmkbbzda3hgvpstyfssllm 370 26 with with IN work_av4lzmkbbzda3hgvpstyfssllm 370 27 PCCA PCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 370 28 and and CC work_av4lzmkbbzda3hgvpstyfssllm 370 29 PCCB PCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 370 30 genes gene NNS work_av4lzmkbbzda3hgvpstyfssllm 370 31 . . . work_av4lzmkbbzda3hgvpstyfssllm 371 1 Proc Proc NNP work_av4lzmkbbzda3hgvpstyfssllm 371 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 372 1 Natl Natl NNP work_av4lzmkbbzda3hgvpstyfssllm 372 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 373 1 Acad Acad NNS work_av4lzmkbbzda3hgvpstyfssllm 373 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 374 1 Sci Sci NNP work_av4lzmkbbzda3hgvpstyfssllm 374 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 375 1 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 375 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 376 1 83:4864–4868 83:4864–4868 CD work_av4lzmkbbzda3hgvpstyfssllm 376 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 377 1 14 14 CD work_av4lzmkbbzda3hgvpstyfssllm 377 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 378 1 Freytag Freytag NNP work_av4lzmkbbzda3hgvpstyfssllm 378 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 378 3 S.O. S.O. NNP work_av4lzmkbbzda3hgvpstyfssllm 378 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 378 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 378 6 Collier Collier NNP work_av4lzmkbbzda3hgvpstyfssllm 378 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 378 8 K.J. K.J. NNP work_av4lzmkbbzda3hgvpstyfssllm 379 1 1984 1984 CD work_av4lzmkbbzda3hgvpstyfssllm 379 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 380 1 Molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 380 2 cloning cloning NN work_av4lzmkbbzda3hgvpstyfssllm 380 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 380 4 a a DT work_av4lzmkbbzda3hgvpstyfssllm 380 5 cDNA cdna NN work_av4lzmkbbzda3hgvpstyfssllm 380 6 for for IN work_av4lzmkbbzda3hgvpstyfssllm 380 7 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 380 8 pyruvate pyruvate JJ work_av4lzmkbbzda3hgvpstyfssllm 380 9 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 380 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 381 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 381 2 Biol Biol NNP work_av4lzmkbbzda3hgvpstyfssllm 381 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 382 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 382 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 383 1 259:12831–12837 259:12831–12837 CD work_av4lzmkbbzda3hgvpstyfssllm 383 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 384 1 15 15 CD work_av4lzmkbbzda3hgvpstyfssllm 384 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 385 1 Abu Abu NNP work_av4lzmkbbzda3hgvpstyfssllm 385 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 385 3 Elheiga Elheiga NNP work_av4lzmkbbzda3hgvpstyfssllm 385 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 5 L. L. NNP work_av4lzmkbbzda3hgvpstyfssllm 385 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 7 Jayakumar Jayakumar NNP work_av4lzmkbbzda3hgvpstyfssllm 385 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 9 A. A. NNP work_av4lzmkbbzda3hgvpstyfssllm 385 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 11 Baldini Baldini NNP work_av4lzmkbbzda3hgvpstyfssllm 385 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 13 A. A. NNP work_av4lzmkbbzda3hgvpstyfssllm 385 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 15 Chirala Chirala NNP work_av4lzmkbbzda3hgvpstyfssllm 385 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 17 S.S. S.S. NNP work_av4lzmkbbzda3hgvpstyfssllm 385 18 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 19 and and CC work_av4lzmkbbzda3hgvpstyfssllm 385 20 Wakil Wakil NNP work_av4lzmkbbzda3hgvpstyfssllm 385 21 , , , work_av4lzmkbbzda3hgvpstyfssllm 385 22 S.J. S.J. NNP work_av4lzmkbbzda3hgvpstyfssllm 386 1 1995 1995 CD work_av4lzmkbbzda3hgvpstyfssllm 386 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 387 1 Human human JJ work_av4lzmkbbzda3hgvpstyfssllm 387 2 acetyl acetyl NN work_av4lzmkbbzda3hgvpstyfssllm 387 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 387 4 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 387 5 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 387 6 : : : work_av4lzmkbbzda3hgvpstyfssllm 387 7 characterization characterization NN work_av4lzmkbbzda3hgvpstyfssllm 387 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 387 9 molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 387 10 cloning cloning NN work_av4lzmkbbzda3hgvpstyfssllm 387 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 387 12 evidence evidence NN work_av4lzmkbbzda3hgvpstyfssllm 387 13 for for IN work_av4lzmkbbzda3hgvpstyfssllm 387 14 two two CD work_av4lzmkbbzda3hgvpstyfssllm 387 15 isoforms isoform NNS work_av4lzmkbbzda3hgvpstyfssllm 387 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 388 1 Proc Proc NNP work_av4lzmkbbzda3hgvpstyfssllm 388 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 389 1 Natl Natl NNP work_av4lzmkbbzda3hgvpstyfssllm 389 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 390 1 Acad Acad NNS work_av4lzmkbbzda3hgvpstyfssllm 390 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 391 1 Sci Sci NNP work_av4lzmkbbzda3hgvpstyfssllm 391 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 392 1 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 392 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 393 1 92:4011–4015 92:4011–4015 CD work_av4lzmkbbzda3hgvpstyfssllm 393 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 394 1 16 16 CD work_av4lzmkbbzda3hgvpstyfssllm 394 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 395 1 Lau Lau NNP work_av4lzmkbbzda3hgvpstyfssllm 395 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 395 3 E.P. E.P. NNP work_av4lzmkbbzda3hgvpstyfssllm 395 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 395 5 Cochran Cochran NNP work_av4lzmkbbzda3hgvpstyfssllm 395 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 395 7 B.C. B.C. NNP work_av4lzmkbbzda3hgvpstyfssllm 395 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 395 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 395 10 Fall Fall NNP work_av4lzmkbbzda3hgvpstyfssllm 395 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 395 12 R.R. R.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 396 1 1980 1980 CD work_av4lzmkbbzda3hgvpstyfssllm 396 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 397 1 Isolation isolation NN work_av4lzmkbbzda3hgvpstyfssllm 397 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 397 3 3-methyl- 3-methyl- NNP work_av4lzmkbbzda3hgvpstyfssllm 397 4 crotonyl crotonyl NN work_av4lzmkbbzda3hgvpstyfssllm 397 5 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 397 6 coenzyme coenzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 397 7 A a DT work_av4lzmkbbzda3hgvpstyfssllm 397 8 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 397 9 from from IN work_av4lzmkbbzda3hgvpstyfssllm 397 10 bovine bovine JJ work_av4lzmkbbzda3hgvpstyfssllm 397 11 kidney kidney NN work_av4lzmkbbzda3hgvpstyfssllm 397 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 398 1 Arch arch UH work_av4lzmkbbzda3hgvpstyfssllm 398 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 399 1 Biochem Biochem NNP work_av4lzmkbbzda3hgvpstyfssllm 399 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 400 1 Biophys Biophys NNP work_av4lzmkbbzda3hgvpstyfssllm 400 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 401 1 205:352–359 205:352–359 LS work_av4lzmkbbzda3hgvpstyfssllm 401 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 402 1 17 17 CD work_av4lzmkbbzda3hgvpstyfssllm 402 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 403 1 Weaver Weaver NNP work_av4lzmkbbzda3hgvpstyfssllm 403 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 403 3 L.M. L.M. NNP work_av4lzmkbbzda3hgvpstyfssllm 403 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 403 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 403 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 403 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 404 1 1995 1995 CD work_av4lzmkbbzda3hgvpstyfssllm 404 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 405 1 Molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 405 2 cloning cloning NN work_av4lzmkbbzda3hgvpstyfssllm 405 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 405 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 405 5 biotinylated biotinylated JJ work_av4lzmkbbzda3hgvpstyfssllm 405 6 sub- sub- DT work_av4lzmkbbzda3hgvpstyfssllm 405 7 unit unit NN work_av4lzmkbbzda3hgvpstyfssllm 405 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 405 9 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 405 10 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 405 11 coenzyme coenzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 405 12 A a DT work_av4lzmkbbzda3hgvpstyfssllm 405 13 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 405 14 of of IN work_av4lzmkbbzda3hgvpstyfssllm 405 15 Arabidopsis arabidopsis NN work_av4lzmkbbzda3hgvpstyfssllm 405 16 thaliana thaliana NNS work_av4lzmkbbzda3hgvpstyfssllm 405 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 406 1 Plant Plant NNP work_av4lzmkbbzda3hgvpstyfssllm 406 2 Physiol Physiol NNP work_av4lzmkbbzda3hgvpstyfssllm 406 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 407 1 107:1013–1014 107:1013–1014 NNS work_av4lzmkbbzda3hgvpstyfssllm 407 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 408 1 18 18 CD work_av4lzmkbbzda3hgvpstyfssllm 408 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 409 1 McKean McKean NNP work_av4lzmkbbzda3hgvpstyfssllm 409 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 409 3 A.L. A.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 409 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 409 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 409 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 409 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 410 1 2000 2000 CD work_av4lzmkbbzda3hgvpstyfssllm 410 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 411 1 Molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 411 2 characterization characterization NN work_av4lzmkbbzda3hgvpstyfssllm 411 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 411 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 411 5 non- non- NNP work_av4lzmkbbzda3hgvpstyfssllm 411 6 biotin biotin NNP work_av4lzmkbbzda3hgvpstyfssllm 411 7 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 411 8 containing contain VBG work_av4lzmkbbzda3hgvpstyfssllm 411 9 subunit subunit NN work_av4lzmkbbzda3hgvpstyfssllm 411 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 411 11 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 411 12 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 411 13 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 411 14 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 411 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 412 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 412 2 Biol Biol NNP work_av4lzmkbbzda3hgvpstyfssllm 412 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 413 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 413 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 414 1 275:5582–5590 275:5582–5590 CD work_av4lzmkbbzda3hgvpstyfssllm 414 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 415 1 19 19 CD work_av4lzmkbbzda3hgvpstyfssllm 415 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 416 1 Mourmans Mourmans NNPS work_av4lzmkbbzda3hgvpstyfssllm 416 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 416 3 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 416 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 416 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 416 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 416 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 417 1 1995 1995 CD work_av4lzmkbbzda3hgvpstyfssllm 417 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 418 1 Isolated isolated JJ work_av4lzmkbbzda3hgvpstyfssllm 418 2 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 418 3 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 418 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 418 5 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 418 6 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 418 7 3-methyl- 3-methyl- CD work_av4lzmkbbzda3hgvpstyfssllm 418 8 crotonyl crotonyl NNP work_av4lzmkbbzda3hgvpstyfssllm 418 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 418 10 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 418 11 carboxylase carboxylase NNP work_av4lzmkbbzda3hgvpstyfssllm 418 12 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 418 13 : : : work_av4lzmkbbzda3hgvpstyfssllm 418 14 four four CD work_av4lzmkbbzda3hgvpstyfssllm 418 15 sibs sibs NN work_av4lzmkbbzda3hgvpstyfssllm 418 16 devoid devoid NN work_av4lzmkbbzda3hgvpstyfssllm 418 17 of of IN work_av4lzmkbbzda3hgvpstyfssllm 418 18 pathology pathology NN work_av4lzmkbbzda3hgvpstyfssllm 418 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 419 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 420 1 Inherit inherit NN work_av4lzmkbbzda3hgvpstyfssllm 420 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 421 1 Metab Metab NNP work_av4lzmkbbzda3hgvpstyfssllm 421 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 422 1 Dis Dis NNP work_av4lzmkbbzda3hgvpstyfssllm 422 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 423 1 18:643–645 18:643–645 LS work_av4lzmkbbzda3hgvpstyfssllm 423 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 424 1 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 424 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 425 1 Gitzelmann Gitzelmann NNP work_av4lzmkbbzda3hgvpstyfssllm 425 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 425 3 R. R. NNP work_av4lzmkbbzda3hgvpstyfssllm 425 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 425 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 425 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 425 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 426 1 1987 1987 CD work_av4lzmkbbzda3hgvpstyfssllm 426 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 427 1 Isolated isolated JJ work_av4lzmkbbzda3hgvpstyfssllm 427 2 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 427 3 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 427 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 427 5 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 427 6 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 427 7 3-methyl- 3-methyl- CD work_av4lzmkbbzda3hgvpstyfssllm 427 8 crotonyl crotonyl NNP work_av4lzmkbbzda3hgvpstyfssllm 427 9 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 427 10 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 427 11 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 427 12 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 427 13 presenting present VBG work_av4lzmkbbzda3hgvpstyfssllm 427 14 at at IN work_av4lzmkbbzda3hgvpstyfssllm 427 15 age age NN work_av4lzmkbbzda3hgvpstyfssllm 427 16 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 427 17 months month NNS work_av4lzmkbbzda3hgvpstyfssllm 427 18 with with IN work_av4lzmkbbzda3hgvpstyfssllm 427 19 sopor sopor NN work_av4lzmkbbzda3hgvpstyfssllm 427 20 , , , work_av4lzmkbbzda3hgvpstyfssllm 427 21 hypoglycaemia hypoglycaemia NN work_av4lzmkbbzda3hgvpstyfssllm 427 22 and and CC work_av4lzmkbbzda3hgvpstyfssllm 427 23 ketoacidosis ketoacidosis NN work_av4lzmkbbzda3hgvpstyfssllm 427 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 428 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 429 1 Inherit inherit NN work_av4lzmkbbzda3hgvpstyfssllm 429 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 430 1 Metab Metab NNP work_av4lzmkbbzda3hgvpstyfssllm 430 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 431 1 Dis Dis NNP work_av4lzmkbbzda3hgvpstyfssllm 431 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 432 1 10(Suppl 10(suppl ADD work_av4lzmkbbzda3hgvpstyfssllm 432 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 433 1 2):290–292 2):290–292 LS work_av4lzmkbbzda3hgvpstyfssllm 433 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 434 1 21 21 CD work_av4lzmkbbzda3hgvpstyfssllm 434 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 435 1 Beemer Beemer NNP work_av4lzmkbbzda3hgvpstyfssllm 435 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 435 3 F.A. F.A. NNP work_av4lzmkbbzda3hgvpstyfssllm 435 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 435 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 435 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 435 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 436 1 1982 1982 CD work_av4lzmkbbzda3hgvpstyfssllm 436 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 437 1 Isolated isolate VBN work_av4lzmkbbzda3hgvpstyfssllm 437 2 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 437 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 437 4 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 437 5 3-methylcrotonyl- 3-methylcrotonyl- NNP work_av4lzmkbbzda3hgvpstyfssllm 437 6 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 437 7 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 437 8 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 437 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 437 10 two two CD work_av4lzmkbbzda3hgvpstyfssllm 437 11 sibs sibs NN work_av4lzmkbbzda3hgvpstyfssllm 437 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 438 1 Eur Eur NNP work_av4lzmkbbzda3hgvpstyfssllm 438 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 439 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 439 2 Pediatr Pediatr NNP work_av4lzmkbbzda3hgvpstyfssllm 439 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 440 1 138:351–354 138:351–354 LS work_av4lzmkbbzda3hgvpstyfssllm 440 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 441 1 22 22 CD work_av4lzmkbbzda3hgvpstyfssllm 441 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 442 1 Wiesmann Wiesmann NNP work_av4lzmkbbzda3hgvpstyfssllm 442 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 3 U.N. U.N. NNP work_av4lzmkbbzda3hgvpstyfssllm 442 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 5 Suormala Suormala NNP work_av4lzmkbbzda3hgvpstyfssllm 442 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 7 T. T. NNP work_av4lzmkbbzda3hgvpstyfssllm 442 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 9 Pfenninger Pfenninger NNP work_av4lzmkbbzda3hgvpstyfssllm 442 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 11 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 442 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 442 14 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 442 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 442 16 E.R. E.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 443 1 1998 1998 CD work_av4lzmkbbzda3hgvpstyfssllm 443 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 444 1 Partial partial JJ work_av4lzmkbbzda3hgvpstyfssllm 444 2 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 444 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 444 4 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 444 5 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 444 6 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 444 7 in in IN work_av4lzmkbbzda3hgvpstyfssllm 444 8 an an DT work_av4lzmkbbzda3hgvpstyfssllm 444 9 infant infant NN work_av4lzmkbbzda3hgvpstyfssllm 444 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 444 11 fatal fatal JJ work_av4lzmkbbzda3hgvpstyfssllm 444 12 outcome outcome NN work_av4lzmkbbzda3hgvpstyfssllm 444 13 due due IN work_av4lzmkbbzda3hgvpstyfssllm 444 14 to to IN work_av4lzmkbbzda3hgvpstyfssllm 444 15 progressive progressive JJ work_av4lzmkbbzda3hgvpstyfssllm 444 16 respiratory respiratory JJ work_av4lzmkbbzda3hgvpstyfssllm 444 17 failure failure NN work_av4lzmkbbzda3hgvpstyfssllm 444 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 445 1 Eur Eur NNP work_av4lzmkbbzda3hgvpstyfssllm 445 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 446 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 446 2 Pediatr Pediatr NNP work_av4lzmkbbzda3hgvpstyfssllm 446 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 447 1 157:225–229 157:225–229 LS work_av4lzmkbbzda3hgvpstyfssllm 447 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 448 1 23 23 CD work_av4lzmkbbzda3hgvpstyfssllm 448 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 449 1 Tsai Tsai NNP work_av4lzmkbbzda3hgvpstyfssllm 449 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 3 M.Y. M.Y. NNP work_av4lzmkbbzda3hgvpstyfssllm 449 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 5 Johnson Johnson NNP work_av4lzmkbbzda3hgvpstyfssllm 449 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 7 D.D. D.D. NNP work_av4lzmkbbzda3hgvpstyfssllm 449 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 9 Sweetman Sweetman NNP work_av4lzmkbbzda3hgvpstyfssllm 449 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 11 L. L. NNP work_av4lzmkbbzda3hgvpstyfssllm 449 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 449 14 Berry Berry NNP work_av4lzmkbbzda3hgvpstyfssllm 449 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 449 16 S.A. S.A. NNP work_av4lzmkbbzda3hgvpstyfssllm 449 17 1989 1989 CD work_av4lzmkbbzda3hgvpstyfssllm 449 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 450 1 Two two CD work_av4lzmkbbzda3hgvpstyfssllm 450 2 siblings sibling NNS work_av4lzmkbbzda3hgvpstyfssllm 450 3 with with IN work_av4lzmkbbzda3hgvpstyfssllm 450 4 biotin biotin NN work_av4lzmkbbzda3hgvpstyfssllm 450 5 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 450 6 resistant resistant JJ work_av4lzmkbbzda3hgvpstyfssllm 450 7 3-methylcrotonyl 3-methylcrotonyl CD work_av4lzmkbbzda3hgvpstyfssllm 450 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 450 9 coenzyme coenzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 450 10 A a DT work_av4lzmkbbzda3hgvpstyfssllm 450 11 car- car- JJ work_av4lzmkbbzda3hgvpstyfssllm 450 12 boxylase boxylase NN work_av4lzmkbbzda3hgvpstyfssllm 450 13 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 450 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 451 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 451 2 Pediatr Pediatr NNP work_av4lzmkbbzda3hgvpstyfssllm 451 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 452 1 115:110–113 115:110–113 CD work_av4lzmkbbzda3hgvpstyfssllm 452 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 453 1 24 24 CD work_av4lzmkbbzda3hgvpstyfssllm 453 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 454 1 Steen Steen NNP work_av4lzmkbbzda3hgvpstyfssllm 454 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 454 3 C. C. NNP work_av4lzmkbbzda3hgvpstyfssllm 454 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 454 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 454 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 454 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 455 1 1999 1999 CD work_av4lzmkbbzda3hgvpstyfssllm 455 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 456 1 Metabolic metabolic JJ work_av4lzmkbbzda3hgvpstyfssllm 456 2 stroke stroke NN work_av4lzmkbbzda3hgvpstyfssllm 456 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 456 4 isolated isolated JJ work_av4lzmkbbzda3hgvpstyfssllm 456 5 3-methylcrotonyl- 3-methylcrotonyl- NNP work_av4lzmkbbzda3hgvpstyfssllm 456 6 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 456 7 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 456 8 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 456 9 . . . work_av4lzmkbbzda3hgvpstyfssllm 457 1 Eur Eur NNP work_av4lzmkbbzda3hgvpstyfssllm 457 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 458 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 458 2 Pediatr Pediatr NNP work_av4lzmkbbzda3hgvpstyfssllm 458 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 459 1 158:730–733 158:730–733 LS work_av4lzmkbbzda3hgvpstyfssllm 459 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 460 1 25 25 CD work_av4lzmkbbzda3hgvpstyfssllm 460 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 461 1 Jurecki Jurecki NNP work_av4lzmkbbzda3hgvpstyfssllm 461 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 461 3 E. E. NNP work_av4lzmkbbzda3hgvpstyfssllm 461 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 461 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 461 6 Packman Packman NNP work_av4lzmkbbzda3hgvpstyfssllm 461 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 461 8 S. S. NNP work_av4lzmkbbzda3hgvpstyfssllm 461 9 1992 1992 CD work_av4lzmkbbzda3hgvpstyfssllm 461 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 462 1 Nutritional nutritional JJ work_av4lzmkbbzda3hgvpstyfssllm 462 2 therapy therapy NN work_av4lzmkbbzda3hgvpstyfssllm 462 3 for for IN work_av4lzmkbbzda3hgvpstyfssllm 462 4 beta- beta- JJ work_av4lzmkbbzda3hgvpstyfssllm 462 5 methylcrotonylglycinuria methylcrotonylglycinuria NNP work_av4lzmkbbzda3hgvpstyfssllm 462 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 463 1 Metabolic Metabolic NNP work_av4lzmkbbzda3hgvpstyfssllm 463 2 Currents current NNS work_av4lzmkbbzda3hgvpstyfssllm 463 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 464 1 5:9–12 5:9–12 CD work_av4lzmkbbzda3hgvpstyfssllm 464 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 465 1 26 26 CD work_av4lzmkbbzda3hgvpstyfssllm 465 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 466 1 Wolf Wolf NNP work_av4lzmkbbzda3hgvpstyfssllm 466 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 466 3 B. B. NNP work_av4lzmkbbzda3hgvpstyfssllm 466 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 466 5 Willard Willard NNP work_av4lzmkbbzda3hgvpstyfssllm 466 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 466 7 H.F. H.F. NNP work_av4lzmkbbzda3hgvpstyfssllm 466 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 466 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 466 10 Rosenberg Rosenberg NNP work_av4lzmkbbzda3hgvpstyfssllm 466 11 LE LE NNP work_av4lzmkbbzda3hgvpstyfssllm 466 12 . . . work_av4lzmkbbzda3hgvpstyfssllm 467 1 1980 1980 CD work_av4lzmkbbzda3hgvpstyfssllm 467 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 468 1 Kinetic kinetic JJ work_av4lzmkbbzda3hgvpstyfssllm 468 2 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 468 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 468 4 genetic genetic JJ work_av4lzmkbbzda3hgvpstyfssllm 468 5 complementation complementation NN work_av4lzmkbbzda3hgvpstyfssllm 468 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 468 7 heterokaryons heterokaryon NNS work_av4lzmkbbzda3hgvpstyfssllm 468 8 of of IN work_av4lzmkbbzda3hgvpstyfssllm 468 9 propionyl propionyl NNP work_av4lzmkbbzda3hgvpstyfssllm 468 10 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 468 11 car- car- POS work_av4lzmkbbzda3hgvpstyfssllm 468 12 boxylase boxylase NN work_av4lzmkbbzda3hgvpstyfssllm 468 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 468 14 deficient deficient JJ work_av4lzmkbbzda3hgvpstyfssllm 468 15 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 468 16 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 468 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 469 1 Am Am NNP work_av4lzmkbbzda3hgvpstyfssllm 469 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 470 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 470 2 Hum Hum NNP work_av4lzmkbbzda3hgvpstyfssllm 470 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 471 1 Genet Genet NNP work_av4lzmkbbzda3hgvpstyfssllm 471 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 472 1 32:16–25 32:16–25 LS work_av4lzmkbbzda3hgvpstyfssllm 472 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 473 1 27 27 CD work_av4lzmkbbzda3hgvpstyfssllm 473 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 474 1 Suormala Suormala NNP work_av4lzmkbbzda3hgvpstyfssllm 474 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 3 T. T. NNP work_av4lzmkbbzda3hgvpstyfssllm 474 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 5 Wick Wick NNP work_av4lzmkbbzda3hgvpstyfssllm 474 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 7 H. H. NNP work_av4lzmkbbzda3hgvpstyfssllm 474 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 9 Bonjour Bonjour NNP work_av4lzmkbbzda3hgvpstyfssllm 474 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 11 J.-P. J.-P. NNP work_av4lzmkbbzda3hgvpstyfssllm 474 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 474 14 Baumgartner Baumgartner NNP work_av4lzmkbbzda3hgvpstyfssllm 474 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 474 16 E.R. E.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 475 1 1985 1985 CD work_av4lzmkbbzda3hgvpstyfssllm 475 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 476 1 Rapid rapid JJ work_av4lzmkbbzda3hgvpstyfssllm 476 2 differential differential NN work_av4lzmkbbzda3hgvpstyfssllm 476 3 diagnosis diagnosis NN work_av4lzmkbbzda3hgvpstyfssllm 476 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 476 5 carboxylase carboxylase NNP work_av4lzmkbbzda3hgvpstyfssllm 476 6 deficiencies deficiency NNS work_av4lzmkbbzda3hgvpstyfssllm 476 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 476 8 evalua- evalua- NNP work_av4lzmkbbzda3hgvpstyfssllm 476 9 tion tion NN work_av4lzmkbbzda3hgvpstyfssllm 476 10 for for IN work_av4lzmkbbzda3hgvpstyfssllm 476 11 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 476 12 responsiveness responsiveness NN work_av4lzmkbbzda3hgvpstyfssllm 476 13 in in IN work_av4lzmkbbzda3hgvpstyfssllm 476 14 a a DT work_av4lzmkbbzda3hgvpstyfssllm 476 15 single single JJ work_av4lzmkbbzda3hgvpstyfssllm 476 16 blood blood NN work_av4lzmkbbzda3hgvpstyfssllm 476 17 sample sample NN work_av4lzmkbbzda3hgvpstyfssllm 476 18 . . . work_av4lzmkbbzda3hgvpstyfssllm 477 1 Clin Clin NNP work_av4lzmkbbzda3hgvpstyfssllm 477 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 478 1 Chim chim UH work_av4lzmkbbzda3hgvpstyfssllm 478 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 479 1 Acta Acta NNP work_av4lzmkbbzda3hgvpstyfssllm 479 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 480 1 145:151–162 145:151–162 LS work_av4lzmkbbzda3hgvpstyfssllm 480 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 481 1 28 28 CD work_av4lzmkbbzda3hgvpstyfssllm 481 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 482 1 Old old JJ work_av4lzmkbbzda3hgvpstyfssllm 482 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 482 3 S.E. S.E. NNP work_av4lzmkbbzda3hgvpstyfssllm 482 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 482 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 482 6 DeVivo DeVivo NNP work_av4lzmkbbzda3hgvpstyfssllm 482 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 482 8 D.C. D.C. NNP work_av4lzmkbbzda3hgvpstyfssllm 482 9 1989 1989 CD work_av4lzmkbbzda3hgvpstyfssllm 482 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 483 1 Pyruvate pyruvate VB work_av4lzmkbbzda3hgvpstyfssllm 483 2 dehydrogenase dehydrogenase JJ work_av4lzmkbbzda3hgvpstyfssllm 483 3 complex complex JJ work_av4lzmkbbzda3hgvpstyfssllm 483 4 deficiency deficiency NN work_av4lzmkbbzda3hgvpstyfssllm 483 5 : : : work_av4lzmkbbzda3hgvpstyfssllm 483 6 biochemical biochemical NNP work_av4lzmkbbzda3hgvpstyfssllm 483 7 and and CC work_av4lzmkbbzda3hgvpstyfssllm 483 8 immunoblot immunoblot NN work_av4lzmkbbzda3hgvpstyfssllm 483 9 analysis analysis NN work_av4lzmkbbzda3hgvpstyfssllm 483 10 of of IN work_av4lzmkbbzda3hgvpstyfssllm 483 11 cultured cultured JJ work_av4lzmkbbzda3hgvpstyfssllm 483 12 skin skin NN work_av4lzmkbbzda3hgvpstyfssllm 483 13 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 483 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 484 1 Ann Ann NNP work_av4lzmkbbzda3hgvpstyfssllm 484 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 485 1 Neurol Neurol NNP work_av4lzmkbbzda3hgvpstyfssllm 485 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 486 1 26:746–751 26:746–751 CD work_av4lzmkbbzda3hgvpstyfssllm 486 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 487 1 29 29 CD work_av4lzmkbbzda3hgvpstyfssllm 487 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 488 1 Nathans Nathans NNP work_av4lzmkbbzda3hgvpstyfssllm 488 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 3 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 488 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 5 Piantanida Piantanida NNP work_av4lzmkbbzda3hgvpstyfssllm 488 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 7 T.P. T.P. NNP work_av4lzmkbbzda3hgvpstyfssllm 488 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 9 Eddy Eddy NNP work_av4lzmkbbzda3hgvpstyfssllm 488 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 11 R.L. R.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 488 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 13 Shows Shows NNP work_av4lzmkbbzda3hgvpstyfssllm 488 14 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 15 T.B. T.B. NNP work_av4lzmkbbzda3hgvpstyfssllm 488 16 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 17 and and CC work_av4lzmkbbzda3hgvpstyfssllm 488 18 Hogness Hogness NNP work_av4lzmkbbzda3hgvpstyfssllm 488 19 , , , work_av4lzmkbbzda3hgvpstyfssllm 488 20 D.S. D.S. NNP work_av4lzmkbbzda3hgvpstyfssllm 489 1 1986 1986 CD work_av4lzmkbbzda3hgvpstyfssllm 489 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 490 1 Molecular molecular JJ work_av4lzmkbbzda3hgvpstyfssllm 490 2 genetics genetic NNS work_av4lzmkbbzda3hgvpstyfssllm 490 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 490 4 inherited inherit VBN work_av4lzmkbbzda3hgvpstyfssllm 490 5 variation variation NN work_av4lzmkbbzda3hgvpstyfssllm 490 6 in in IN work_av4lzmkbbzda3hgvpstyfssllm 490 7 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 490 8 color color NN work_av4lzmkbbzda3hgvpstyfssllm 490 9 vision vision NN work_av4lzmkbbzda3hgvpstyfssllm 490 10 . . . work_av4lzmkbbzda3hgvpstyfssllm 491 1 Science science NN work_av4lzmkbbzda3hgvpstyfssllm 491 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 492 1 232:203–210 232:203–210 LS work_av4lzmkbbzda3hgvpstyfssllm 492 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 493 1 Table table NN work_av4lzmkbbzda3hgvpstyfssllm 493 2 3 3 CD work_av4lzmkbbzda3hgvpstyfssllm 493 3 ExpressionA expressiona NN work_av4lzmkbbzda3hgvpstyfssllm 493 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 493 5 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 493 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 493 7 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 493 8 alleles allele VBZ work_av4lzmkbbzda3hgvpstyfssllm 493 9 Allele Allele NNP work_av4lzmkbbzda3hgvpstyfssllm 493 10 Enzyme Enzyme NNP work_av4lzmkbbzda3hgvpstyfssllm 493 11 activityB activityB NNP work_av4lzmkbbzda3hgvpstyfssllm 493 12 ( ( -LRB- work_av4lzmkbbzda3hgvpstyfssllm 493 13 pmol pmol NNP work_av4lzmkbbzda3hgvpstyfssllm 493 14 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 493 15 min min NNP work_av4lzmkbbzda3hgvpstyfssllm 493 16 / / SYM work_av4lzmkbbzda3hgvpstyfssllm 493 17 mg mg NNP work_av4lzmkbbzda3hgvpstyfssllm 493 18 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 493 19 ) ) -RRB- work_av4lzmkbbzda3hgvpstyfssllm 493 20 Experiment experiment NN work_av4lzmkbbzda3hgvpstyfssllm 493 21 1 1 CD work_av4lzmkbbzda3hgvpstyfssllm 493 22 Experiment Experiment NNP work_av4lzmkbbzda3hgvpstyfssllm 493 23 2 2 CD work_av4lzmkbbzda3hgvpstyfssllm 493 24 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 493 25 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 493 26 MCC MCC NNP work_av4lzmkbbzda3hgvpstyfssllm 493 27 PCC PCC NNP work_av4lzmkbbzda3hgvpstyfssllm 493 28 MCCA MCCA NNP work_av4lzmkbbzda3hgvpstyfssllm 493 29 Wild Wild NNP work_av4lzmkbbzda3hgvpstyfssllm 493 30 type type NN work_av4lzmkbbzda3hgvpstyfssllm 493 31 137 137 CD work_av4lzmkbbzda3hgvpstyfssllm 493 32 415 415 CD work_av4lzmkbbzda3hgvpstyfssllm 493 33 R385S r385s CD work_av4lzmkbbzda3hgvpstyfssllm 493 34 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 35 251 251 CD work_av4lzmkbbzda3hgvpstyfssllm 493 36 A289V a289v CD work_av4lzmkbbzda3hgvpstyfssllm 493 37 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 38 289 289 CD work_av4lzmkbbzda3hgvpstyfssllm 493 39 L437P l437p SYM work_av4lzmkbbzda3hgvpstyfssllm 493 40 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 41 252 252 CD work_av4lzmkbbzda3hgvpstyfssllm 493 42 Vector vector NN work_av4lzmkbbzda3hgvpstyfssllm 493 43 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 44 234 234 CD work_av4lzmkbbzda3hgvpstyfssllm 493 45 MCCB MCCB NNP work_av4lzmkbbzda3hgvpstyfssllm 493 46 Wild Wild NNP work_av4lzmkbbzda3hgvpstyfssllm 493 47 type type NN work_av4lzmkbbzda3hgvpstyfssllm 493 48 170 170 CD work_av4lzmkbbzda3hgvpstyfssllm 493 49 548 548 CD work_av4lzmkbbzda3hgvpstyfssllm 493 50 110 110 CD work_av4lzmkbbzda3hgvpstyfssllm 493 51 474 474 CD work_av4lzmkbbzda3hgvpstyfssllm 493 52 S173L s173l CD work_av4lzmkbbzda3hgvpstyfssllm 493 53 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 54 323 323 CD work_av4lzmkbbzda3hgvpstyfssllm 493 55 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 56 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 57 E99Q E99Q NNP work_av4lzmkbbzda3hgvpstyfssllm 493 58 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 59 581 581 CD work_av4lzmkbbzda3hgvpstyfssllm 493 60 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 61 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 62 V339 V339 NNP work_av4lzmkbbzda3hgvpstyfssllm 493 63 M M NNP work_av4lzmkbbzda3hgvpstyfssllm 493 64 7 7 CD work_av4lzmkbbzda3hgvpstyfssllm 493 65 336 336 CD work_av4lzmkbbzda3hgvpstyfssllm 493 66 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 67 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 68 R155Q r155q CD work_av4lzmkbbzda3hgvpstyfssllm 493 69 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 70 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 71 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 72 359 359 CD work_av4lzmkbbzda3hgvpstyfssllm 493 73 P310R p310r CD work_av4lzmkbbzda3hgvpstyfssllm 493 74 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 75 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 76 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 77 370 370 CD work_av4lzmkbbzda3hgvpstyfssllm 493 78 R193C r193c CD work_av4lzmkbbzda3hgvpstyfssllm 493 79 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 80 – – : work_av4lzmkbbzda3hgvpstyfssllm 493 81 6 6 CD work_av4lzmkbbzda3hgvpstyfssllm 493 82 373 373 CD work_av4lzmkbbzda3hgvpstyfssllm 493 83 Vector Vector NNP work_av4lzmkbbzda3hgvpstyfssllm 493 84 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 85 298 298 CD work_av4lzmkbbzda3hgvpstyfssllm 493 86 0 0 CD work_av4lzmkbbzda3hgvpstyfssllm 493 87 587 587 CD work_av4lzmkbbzda3hgvpstyfssllm 493 88 Control Control NNP work_av4lzmkbbzda3hgvpstyfssllm 493 89 318 318 CD work_av4lzmkbbzda3hgvpstyfssllm 493 90 345 345 CD work_av4lzmkbbzda3hgvpstyfssllm 493 91 325 325 CD work_av4lzmkbbzda3hgvpstyfssllm 493 92 436 436 CD work_av4lzmkbbzda3hgvpstyfssllm 493 93 fibroblasts fibroblast NNS work_av4lzmkbbzda3hgvpstyfssllm 493 94 ATransient atransient JJ work_av4lzmkbbzda3hgvpstyfssllm 493 95 transfection transfection NN work_av4lzmkbbzda3hgvpstyfssllm 493 96 in in IN work_av4lzmkbbzda3hgvpstyfssllm 493 97 SV40T sv40t NN work_av4lzmkbbzda3hgvpstyfssllm 493 98 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 493 99 transformed transform VBN work_av4lzmkbbzda3hgvpstyfssllm 493 100 reference reference NN work_av4lzmkbbzda3hgvpstyfssllm 493 101 CG1 CG1 NNP work_av4lzmkbbzda3hgvpstyfssllm 493 102 or or CC work_av4lzmkbbzda3hgvpstyfssllm 493 103 CG2 CG2 NNP work_av4lzmkbbzda3hgvpstyfssllm 493 104 cell cell NN work_av4lzmkbbzda3hgvpstyfssllm 493 105 lines line NNS work_av4lzmkbbzda3hgvpstyfssllm 493 106 . . . work_av4lzmkbbzda3hgvpstyfssllm 494 1 BNumbers bnumber NNS work_av4lzmkbbzda3hgvpstyfssllm 494 2 represent represent VBP work_av4lzmkbbzda3hgvpstyfssllm 494 3 average average JJ work_av4lzmkbbzda3hgvpstyfssllm 494 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 494 5 duplicates duplicate NNS work_av4lzmkbbzda3hgvpstyfssllm 494 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 495 1 504 504 CD work_av4lzmkbbzda3hgvpstyfssllm 495 2 The the DT work_av4lzmkbbzda3hgvpstyfssllm 495 3 Journal Journal NNP work_av4lzmkbbzda3hgvpstyfssllm 495 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 495 5 Clinical Clinical NNP work_av4lzmkbbzda3hgvpstyfssllm 495 6 Investigation Investigation NNP work_av4lzmkbbzda3hgvpstyfssllm 495 7 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 495 8 February February NNP work_av4lzmkbbzda3hgvpstyfssllm 495 9 2001 2001 CD work_av4lzmkbbzda3hgvpstyfssllm 495 10 | | NNP work_av4lzmkbbzda3hgvpstyfssllm 495 11 Volume Volume NNP work_av4lzmkbbzda3hgvpstyfssllm 495 12 107 107 CD work_av4lzmkbbzda3hgvpstyfssllm 495 13 | | CD work_av4lzmkbbzda3hgvpstyfssllm 495 14 Number Number NNP work_av4lzmkbbzda3hgvpstyfssllm 495 15 4 4 CD work_av4lzmkbbzda3hgvpstyfssllm 495 16 30 30 CD work_av4lzmkbbzda3hgvpstyfssllm 495 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 496 1 Williams Williams NNP work_av4lzmkbbzda3hgvpstyfssllm 496 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 496 3 K. K. NNP work_av4lzmkbbzda3hgvpstyfssllm 496 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 496 5 LoPresti LoPresti NNP work_av4lzmkbbzda3hgvpstyfssllm 496 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 496 7 M. M. NNP work_av4lzmkbbzda3hgvpstyfssllm 496 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 496 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 496 10 Stone Stone NNP work_av4lzmkbbzda3hgvpstyfssllm 496 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 496 12 K. K. NNP work_av4lzmkbbzda3hgvpstyfssllm 496 13 1997 1997 CD work_av4lzmkbbzda3hgvpstyfssllm 496 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 497 1 Internal internal JJ work_av4lzmkbbzda3hgvpstyfssllm 497 2 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 497 3 sequencing sequencing NN work_av4lzmkbbzda3hgvpstyfssllm 497 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 497 5 SDS SDS NNP work_av4lzmkbbzda3hgvpstyfssllm 497 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 497 7 PAGE PAGE NNP work_av4lzmkbbzda3hgvpstyfssllm 497 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 497 9 separated separate VBN work_av4lzmkbbzda3hgvpstyfssllm 497 10 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 497 11 : : : work_av4lzmkbbzda3hgvpstyfssllm 497 12 optimization optimization NN work_av4lzmkbbzda3hgvpstyfssllm 497 13 of of IN work_av4lzmkbbzda3hgvpstyfssllm 497 14 an an DT work_av4lzmkbbzda3hgvpstyfssllm 497 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 497 16 gel gel FW work_av4lzmkbbzda3hgvpstyfssllm 497 17 digest digest NNP work_av4lzmkbbzda3hgvpstyfssllm 497 18 protocol protocol NN work_av4lzmkbbzda3hgvpstyfssllm 497 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 498 1 In in IN work_av4lzmkbbzda3hgvpstyfssllm 498 2 Techniques technique NNS work_av4lzmkbbzda3hgvpstyfssllm 498 3 in in IN work_av4lzmkbbzda3hgvpstyfssllm 498 4 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 498 5 chemistry chemistry NN work_av4lzmkbbzda3hgvpstyfssllm 498 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 499 1 D.R. D.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 500 1 Marshak marshak NN work_av4lzmkbbzda3hgvpstyfssllm 500 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 500 3 editor editor NN work_av4lzmkbbzda3hgvpstyfssllm 500 4 . . . work_av4lzmkbbzda3hgvpstyfssllm 501 1 Academic Academic NNP work_av4lzmkbbzda3hgvpstyfssllm 501 2 Press Press NNP work_av4lzmkbbzda3hgvpstyfssllm 501 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 502 1 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 502 2 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 502 3 , , , work_av4lzmkbbzda3hgvpstyfssllm 502 4 New New NNP work_av4lzmkbbzda3hgvpstyfssllm 502 5 York York NNP work_av4lzmkbbzda3hgvpstyfssllm 502 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 502 7 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 502 8 . . . work_av4lzmkbbzda3hgvpstyfssllm 503 1 79–90 79–90 CD work_av4lzmkbbzda3hgvpstyfssllm 503 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 504 1 31 31 CD work_av4lzmkbbzda3hgvpstyfssllm 504 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 505 1 Smith Smith NNP work_av4lzmkbbzda3hgvpstyfssllm 505 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 505 3 B.J. B.J. NNP work_av4lzmkbbzda3hgvpstyfssllm 506 1 1994 1994 CD work_av4lzmkbbzda3hgvpstyfssllm 506 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 507 1 Chemical chemical JJ work_av4lzmkbbzda3hgvpstyfssllm 507 2 cleavage cleavage NN work_av4lzmkbbzda3hgvpstyfssllm 507 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 507 4 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 507 5 . . . work_av4lzmkbbzda3hgvpstyfssllm 508 1 Methods Methods NNPS work_av4lzmkbbzda3hgvpstyfssllm 508 2 Mol Mol NNP work_av4lzmkbbzda3hgvpstyfssllm 508 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 509 1 Biol Biol NNP work_av4lzmkbbzda3hgvpstyfssllm 509 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 510 1 32:297–309 32:297–309 CD work_av4lzmkbbzda3hgvpstyfssllm 510 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 511 1 32 32 CD work_av4lzmkbbzda3hgvpstyfssllm 511 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 512 1 Kennedy Kennedy NNP work_av4lzmkbbzda3hgvpstyfssllm 512 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 512 3 R.T. R.T. NNP work_av4lzmkbbzda3hgvpstyfssllm 512 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 512 5 and and CC work_av4lzmkbbzda3hgvpstyfssllm 512 6 Jorgenson Jorgenson NNP work_av4lzmkbbzda3hgvpstyfssllm 512 7 , , , work_av4lzmkbbzda3hgvpstyfssllm 512 8 J.W. J.W. NNP work_av4lzmkbbzda3hgvpstyfssllm 513 1 1989 1989 CD work_av4lzmkbbzda3hgvpstyfssllm 513 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 514 1 Preparation preparation NN work_av4lzmkbbzda3hgvpstyfssllm 514 2 and and CC work_av4lzmkbbzda3hgvpstyfssllm 514 3 evaluation evaluation NN work_av4lzmkbbzda3hgvpstyfssllm 514 4 of of IN work_av4lzmkbbzda3hgvpstyfssllm 514 5 packed pack VBN work_av4lzmkbbzda3hgvpstyfssllm 514 6 capillary capillary JJ work_av4lzmkbbzda3hgvpstyfssllm 514 7 liquid liquid JJ work_av4lzmkbbzda3hgvpstyfssllm 514 8 chromatography chromatography NN work_av4lzmkbbzda3hgvpstyfssllm 514 9 columns column NNS work_av4lzmkbbzda3hgvpstyfssllm 514 10 with with IN work_av4lzmkbbzda3hgvpstyfssllm 514 11 inner inner JJ work_av4lzmkbbzda3hgvpstyfssllm 514 12 diam- diam- JJ work_av4lzmkbbzda3hgvpstyfssllm 514 13 eters eter NNS work_av4lzmkbbzda3hgvpstyfssllm 514 14 from from IN work_av4lzmkbbzda3hgvpstyfssllm 514 15 20 20 CD work_av4lzmkbbzda3hgvpstyfssllm 514 16 to to TO work_av4lzmkbbzda3hgvpstyfssllm 514 17 50 50 CD work_av4lzmkbbzda3hgvpstyfssllm 514 18 µm µm NNS work_av4lzmkbbzda3hgvpstyfssllm 514 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 515 1 Anal anal JJ work_av4lzmkbbzda3hgvpstyfssllm 515 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 516 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 516 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 517 1 61:1128–1135 61:1128–1135 CD work_av4lzmkbbzda3hgvpstyfssllm 517 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 518 1 33 33 CD work_av4lzmkbbzda3hgvpstyfssllm 518 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 519 1 Eng Eng NNP work_av4lzmkbbzda3hgvpstyfssllm 519 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 3 J.K. J.K. NNP work_av4lzmkbbzda3hgvpstyfssllm 519 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 5 McCormak McCormak NNP work_av4lzmkbbzda3hgvpstyfssllm 519 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 7 A.L. A.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 519 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 9 Ashley Ashley NNP work_av4lzmkbbzda3hgvpstyfssllm 519 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 11 L. L. NNP work_av4lzmkbbzda3hgvpstyfssllm 519 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 519 14 Yates Yates NNP work_av4lzmkbbzda3hgvpstyfssllm 519 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 519 16 J.R.I. J.R.I. NNP work_av4lzmkbbzda3hgvpstyfssllm 520 1 1994 1994 CD work_av4lzmkbbzda3hgvpstyfssllm 520 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 521 1 An an DT work_av4lzmkbbzda3hgvpstyfssllm 521 2 approach approach NN work_av4lzmkbbzda3hgvpstyfssllm 521 3 to to TO work_av4lzmkbbzda3hgvpstyfssllm 521 4 correlate correlate VB work_av4lzmkbbzda3hgvpstyfssllm 521 5 tandem tandem NN work_av4lzmkbbzda3hgvpstyfssllm 521 6 mass mass JJ work_av4lzmkbbzda3hgvpstyfssllm 521 7 spectral spectral JJ work_av4lzmkbbzda3hgvpstyfssllm 521 8 data datum NNS work_av4lzmkbbzda3hgvpstyfssllm 521 9 of of IN work_av4lzmkbbzda3hgvpstyfssllm 521 10 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 521 11 with with IN work_av4lzmkbbzda3hgvpstyfssllm 521 12 amino amino JJ work_av4lzmkbbzda3hgvpstyfssllm 521 13 acid acid NN work_av4lzmkbbzda3hgvpstyfssllm 521 14 sequences sequence NNS work_av4lzmkbbzda3hgvpstyfssllm 521 15 in in IN work_av4lzmkbbzda3hgvpstyfssllm 521 16 a a DT work_av4lzmkbbzda3hgvpstyfssllm 521 17 protein protein NN work_av4lzmkbbzda3hgvpstyfssllm 521 18 database database NN work_av4lzmkbbzda3hgvpstyfssllm 521 19 . . . work_av4lzmkbbzda3hgvpstyfssllm 522 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 523 1 Am Am NNP work_av4lzmkbbzda3hgvpstyfssllm 523 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 524 1 Soc Soc NNP work_av4lzmkbbzda3hgvpstyfssllm 524 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 525 1 Mass Mass NNP work_av4lzmkbbzda3hgvpstyfssllm 525 2 Spectrom Spectrom NNP work_av4lzmkbbzda3hgvpstyfssllm 525 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 526 1 5:976–989 5:976–989 CD work_av4lzmkbbzda3hgvpstyfssllm 526 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 527 1 34 34 CD work_av4lzmkbbzda3hgvpstyfssllm 527 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 528 1 Braverman Braverman NNP work_av4lzmkbbzda3hgvpstyfssllm 528 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 528 3 N. N. NNP work_av4lzmkbbzda3hgvpstyfssllm 528 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 528 5 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 528 6 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 528 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 529 1 1997 1997 CD work_av4lzmkbbzda3hgvpstyfssllm 529 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 530 1 Human Human NNP work_av4lzmkbbzda3hgvpstyfssllm 530 2 PEX7 PEX7 NNP work_av4lzmkbbzda3hgvpstyfssllm 530 3 encodes encode VBZ work_av4lzmkbbzda3hgvpstyfssllm 530 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 530 5 peroxisomal peroxisomal NN work_av4lzmkbbzda3hgvpstyfssllm 530 6 PTS2 PTS2 NNP work_av4lzmkbbzda3hgvpstyfssllm 530 7 receptor receptor NN work_av4lzmkbbzda3hgvpstyfssllm 530 8 and and CC work_av4lzmkbbzda3hgvpstyfssllm 530 9 is be VBZ work_av4lzmkbbzda3hgvpstyfssllm 530 10 responsible responsible JJ work_av4lzmkbbzda3hgvpstyfssllm 530 11 for for IN work_av4lzmkbbzda3hgvpstyfssllm 530 12 rhizomelic rhizomelic NNP work_av4lzmkbbzda3hgvpstyfssllm 530 13 chondrodysplasia chondrodysplasia NNP work_av4lzmkbbzda3hgvpstyfssllm 530 14 punctata punctata NNP work_av4lzmkbbzda3hgvpstyfssllm 530 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 531 1 Nat Nat NNP work_av4lzmkbbzda3hgvpstyfssllm 531 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 532 1 Genet Genet NNP work_av4lzmkbbzda3hgvpstyfssllm 532 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 533 1 15:369–376 15:369–376 ADD work_av4lzmkbbzda3hgvpstyfssllm 533 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 534 1 35 35 CD work_av4lzmkbbzda3hgvpstyfssllm 534 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 535 1 Leon Leon NNP work_av4lzmkbbzda3hgvpstyfssllm 535 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 535 3 Del Del NNP work_av4lzmkbbzda3hgvpstyfssllm 535 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 535 5 Rio Rio NNP work_av4lzmkbbzda3hgvpstyfssllm 535 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 535 7 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 535 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 535 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 535 10 Gravel Gravel NNP work_av4lzmkbbzda3hgvpstyfssllm 535 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 535 12 R.A. R.A. NNP work_av4lzmkbbzda3hgvpstyfssllm 535 13 1994 1994 CD work_av4lzmkbbzda3hgvpstyfssllm 535 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 536 1 Sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 536 2 requirements requirement NNS work_av4lzmkbbzda3hgvpstyfssllm 536 3 for for IN work_av4lzmkbbzda3hgvpstyfssllm 536 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 536 5 biotinylation biotinylation NN work_av4lzmkbbzda3hgvpstyfssllm 536 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 536 7 carboxyl carboxyl NN work_av4lzmkbbzda3hgvpstyfssllm 536 8 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 536 9 terminal terminal JJ work_av4lzmkbbzda3hgvpstyfssllm 536 10 fragments fragment NNS work_av4lzmkbbzda3hgvpstyfssllm 536 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 536 12 human human JJ work_av4lzmkbbzda3hgvpstyfssllm 536 13 propi- propi- NNP work_av4lzmkbbzda3hgvpstyfssllm 536 14 onyl onyl NNP work_av4lzmkbbzda3hgvpstyfssllm 536 15 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 536 16 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 536 17 carboxylase carboxylase NNP work_av4lzmkbbzda3hgvpstyfssllm 536 18 alpha alpha NN work_av4lzmkbbzda3hgvpstyfssllm 536 19 subunit subunit VBD work_av4lzmkbbzda3hgvpstyfssllm 536 20 expression expression NN work_av4lzmkbbzda3hgvpstyfssllm 536 21 in in IN work_av4lzmkbbzda3hgvpstyfssllm 536 22 Escherichia Escherichia NNP work_av4lzmkbbzda3hgvpstyfssllm 536 23 coli coli NNS work_av4lzmkbbzda3hgvpstyfssllm 536 24 . . . work_av4lzmkbbzda3hgvpstyfssllm 537 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 537 2 Biol Biol NNP work_av4lzmkbbzda3hgvpstyfssllm 537 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 538 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 538 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 539 1 269:22964–22968 269:22964–22968 CD work_av4lzmkbbzda3hgvpstyfssllm 539 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 540 1 36 36 CD work_av4lzmkbbzda3hgvpstyfssllm 540 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 541 1 Waldrop Waldrop NNP work_av4lzmkbbzda3hgvpstyfssllm 541 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 541 3 G.L. G.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 541 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 541 5 Rayment Rayment NNP work_av4lzmkbbzda3hgvpstyfssllm 541 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 541 7 I. I. NNP work_av4lzmkbbzda3hgvpstyfssllm 541 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 541 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 541 10 Holden Holden NNP work_av4lzmkbbzda3hgvpstyfssllm 541 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 541 12 H.M. H.M. NNP work_av4lzmkbbzda3hgvpstyfssllm 541 13 1994 1994 CD work_av4lzmkbbzda3hgvpstyfssllm 541 14 . . . work_av4lzmkbbzda3hgvpstyfssllm 542 1 Three three CD work_av4lzmkbbzda3hgvpstyfssllm 542 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 542 3 dimen- dimen- NN work_av4lzmkbbzda3hgvpstyfssllm 542 4 sional sional JJ work_av4lzmkbbzda3hgvpstyfssllm 542 5 structure structure NN work_av4lzmkbbzda3hgvpstyfssllm 542 6 of of IN work_av4lzmkbbzda3hgvpstyfssllm 542 7 the the DT work_av4lzmkbbzda3hgvpstyfssllm 542 8 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 542 9 carboxylase carboxylase NNP work_av4lzmkbbzda3hgvpstyfssllm 542 10 subunit subunit NNP work_av4lzmkbbzda3hgvpstyfssllm 542 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 542 12 acetyl acetyl NNP work_av4lzmkbbzda3hgvpstyfssllm 542 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 542 14 CoA CoA NNP work_av4lzmkbbzda3hgvpstyfssllm 542 15 car- car- NNP work_av4lzmkbbzda3hgvpstyfssllm 542 16 boxylase boxylase NN work_av4lzmkbbzda3hgvpstyfssllm 542 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 543 1 Biochemistry Biochemistry NNP work_av4lzmkbbzda3hgvpstyfssllm 543 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 544 1 33:10249–10256 33:10249–10256 NNP work_av4lzmkbbzda3hgvpstyfssllm 544 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 545 1 37 37 CD work_av4lzmkbbzda3hgvpstyfssllm 545 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 546 1 Thoden Thoden NNP work_av4lzmkbbzda3hgvpstyfssllm 546 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 3 J.B. J.B. NNP work_av4lzmkbbzda3hgvpstyfssllm 546 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 5 Blanchard Blanchard NNP work_av4lzmkbbzda3hgvpstyfssllm 546 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 7 C.Z. C.Z. NNP work_av4lzmkbbzda3hgvpstyfssllm 546 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 9 Holden Holden NNP work_av4lzmkbbzda3hgvpstyfssllm 546 10 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 11 H.M. H.M. NNP work_av4lzmkbbzda3hgvpstyfssllm 546 12 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 13 and and CC work_av4lzmkbbzda3hgvpstyfssllm 546 14 Waldrop Waldrop NNP work_av4lzmkbbzda3hgvpstyfssllm 546 15 , , , work_av4lzmkbbzda3hgvpstyfssllm 546 16 G.L. G.L. NNP work_av4lzmkbbzda3hgvpstyfssllm 547 1 2000 2000 CD work_av4lzmkbbzda3hgvpstyfssllm 547 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 548 1 Movement movement NN work_av4lzmkbbzda3hgvpstyfssllm 548 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 548 3 biotin biotin JJ work_av4lzmkbbzda3hgvpstyfssllm 548 4 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 548 5 B B NNP work_av4lzmkbbzda3hgvpstyfssllm 548 6 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 548 7 domain domain NN work_av4lzmkbbzda3hgvpstyfssllm 548 8 as as IN work_av4lzmkbbzda3hgvpstyfssllm 548 9 a a DT work_av4lzmkbbzda3hgvpstyfssllm 548 10 result result NN work_av4lzmkbbzda3hgvpstyfssllm 548 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 548 12 ATP ATP NNP work_av4lzmkbbzda3hgvpstyfssllm 548 13 bind- bind- NN work_av4lzmkbbzda3hgvpstyfssllm 548 14 ing ing NN work_av4lzmkbbzda3hgvpstyfssllm 548 15 . . . work_av4lzmkbbzda3hgvpstyfssllm 549 1 J. J. NNP work_av4lzmkbbzda3hgvpstyfssllm 549 2 Biol Biol NNP work_av4lzmkbbzda3hgvpstyfssllm 549 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 550 1 Chem Chem NNP work_av4lzmkbbzda3hgvpstyfssllm 550 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 551 1 275:16183–16190 275:16183–16190 LS work_av4lzmkbbzda3hgvpstyfssllm 551 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 552 1 38 38 CD work_av4lzmkbbzda3hgvpstyfssllm 552 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 553 1 Saraste Saraste NNP work_av4lzmkbbzda3hgvpstyfssllm 553 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 553 3 M. M. NNP work_av4lzmkbbzda3hgvpstyfssllm 553 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 553 5 Sibbald Sibbald NNP work_av4lzmkbbzda3hgvpstyfssllm 553 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 553 7 P.R. P.R. NNP work_av4lzmkbbzda3hgvpstyfssllm 553 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 553 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 553 10 Wittinghofer Wittinghofer NNP work_av4lzmkbbzda3hgvpstyfssllm 553 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 553 12 A. a. NN work_av4lzmkbbzda3hgvpstyfssllm 554 1 1990 1990 CD work_av4lzmkbbzda3hgvpstyfssllm 554 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 555 1 The the DT work_av4lzmkbbzda3hgvpstyfssllm 555 2 P P NNP work_av4lzmkbbzda3hgvpstyfssllm 555 3 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 555 4 loop loop NNP work_av4lzmkbbzda3hgvpstyfssllm 555 5 : : : work_av4lzmkbbzda3hgvpstyfssllm 555 6 a a DT work_av4lzmkbbzda3hgvpstyfssllm 555 7 common common JJ work_av4lzmkbbzda3hgvpstyfssllm 555 8 motif motif NN work_av4lzmkbbzda3hgvpstyfssllm 555 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 555 10 ATP- ATP- NNP work_av4lzmkbbzda3hgvpstyfssllm 555 11 and and CC work_av4lzmkbbzda3hgvpstyfssllm 555 12 GTP GTP NNP work_av4lzmkbbzda3hgvpstyfssllm 555 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 555 14 binding bind VBG work_av4lzmkbbzda3hgvpstyfssllm 555 15 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 555 16 . . . work_av4lzmkbbzda3hgvpstyfssllm 556 1 Trends Trends NNPS work_av4lzmkbbzda3hgvpstyfssllm 556 2 Biochem Biochem NNP work_av4lzmkbbzda3hgvpstyfssllm 556 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 557 1 Sci Sci NNP work_av4lzmkbbzda3hgvpstyfssllm 557 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 558 1 15:430–434 15:430–434 ADD work_av4lzmkbbzda3hgvpstyfssllm 558 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 559 1 39 39 CD work_av4lzmkbbzda3hgvpstyfssllm 559 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 560 1 López López NNP work_av4lzmkbbzda3hgvpstyfssllm 560 2 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 560 3 Casillas Casillas NNP work_av4lzmkbbzda3hgvpstyfssllm 560 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 560 5 F. F. NNP work_av4lzmkbbzda3hgvpstyfssllm 560 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 560 7 et et NNP work_av4lzmkbbzda3hgvpstyfssllm 560 8 al al NNP work_av4lzmkbbzda3hgvpstyfssllm 560 9 . . . work_av4lzmkbbzda3hgvpstyfssllm 561 1 1988 1988 CD work_av4lzmkbbzda3hgvpstyfssllm 561 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 562 1 Structure structure NN work_av4lzmkbbzda3hgvpstyfssllm 562 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 562 3 the the DT work_av4lzmkbbzda3hgvpstyfssllm 562 4 coding code VBG work_av4lzmkbbzda3hgvpstyfssllm 562 5 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 562 6 and and CC work_av4lzmkbbzda3hgvpstyfssllm 562 7 primary primary JJ work_av4lzmkbbzda3hgvpstyfssllm 562 8 amino amino NN work_av4lzmkbbzda3hgvpstyfssllm 562 9 acid acid JJ work_av4lzmkbbzda3hgvpstyfssllm 562 10 sequence sequence NN work_av4lzmkbbzda3hgvpstyfssllm 562 11 of of IN work_av4lzmkbbzda3hgvpstyfssllm 562 12 acetyl acetyl NN work_av4lzmkbbzda3hgvpstyfssllm 562 13 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 562 14 coenzyme coenzyme NNS work_av4lzmkbbzda3hgvpstyfssllm 562 15 A a DT work_av4lzmkbbzda3hgvpstyfssllm 562 16 carboxylase carboxylase NN work_av4lzmkbbzda3hgvpstyfssllm 562 17 . . . work_av4lzmkbbzda3hgvpstyfssllm 563 1 Proc Proc NNP work_av4lzmkbbzda3hgvpstyfssllm 563 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 564 1 Natl Natl NNP work_av4lzmkbbzda3hgvpstyfssllm 564 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 565 1 Acad Acad NNS work_av4lzmkbbzda3hgvpstyfssllm 565 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 566 1 Sci Sci NNP work_av4lzmkbbzda3hgvpstyfssllm 566 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 567 1 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 567 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 568 1 85:5784–5788 85:5784–5788 NNP work_av4lzmkbbzda3hgvpstyfssllm 568 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 569 1 40 40 CD work_av4lzmkbbzda3hgvpstyfssllm 569 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 570 1 Hendrick Hendrick NNP work_av4lzmkbbzda3hgvpstyfssllm 570 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 570 3 J.P. J.P. NNP work_av4lzmkbbzda3hgvpstyfssllm 570 4 , , , work_av4lzmkbbzda3hgvpstyfssllm 570 5 Hodges Hodges NNP work_av4lzmkbbzda3hgvpstyfssllm 570 6 , , , work_av4lzmkbbzda3hgvpstyfssllm 570 7 P.E. P.E. NNP work_av4lzmkbbzda3hgvpstyfssllm 570 8 , , , work_av4lzmkbbzda3hgvpstyfssllm 570 9 and and CC work_av4lzmkbbzda3hgvpstyfssllm 570 10 Rosenberg Rosenberg NNP work_av4lzmkbbzda3hgvpstyfssllm 570 11 , , , work_av4lzmkbbzda3hgvpstyfssllm 570 12 L.E. L.E. NNP work_av4lzmkbbzda3hgvpstyfssllm 571 1 1989 1989 CD work_av4lzmkbbzda3hgvpstyfssllm 571 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 572 1 Survey survey NN work_av4lzmkbbzda3hgvpstyfssllm 572 2 of of IN work_av4lzmkbbzda3hgvpstyfssllm 572 3 amino amino NN work_av4lzmkbbzda3hgvpstyfssllm 572 4 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 572 5 terminal terminal NN work_av4lzmkbbzda3hgvpstyfssllm 572 6 proteolytic proteolytic JJ work_av4lzmkbbzda3hgvpstyfssllm 572 7 cleavage cleavage NN work_av4lzmkbbzda3hgvpstyfssllm 572 8 sites site NNS work_av4lzmkbbzda3hgvpstyfssllm 572 9 in in IN work_av4lzmkbbzda3hgvpstyfssllm 572 10 mitochondrial mitochondrial NN work_av4lzmkbbzda3hgvpstyfssllm 572 11 precur- precur- NNP work_av4lzmkbbzda3hgvpstyfssllm 572 12 sor sor NNP work_av4lzmkbbzda3hgvpstyfssllm 572 13 proteins protein NNS work_av4lzmkbbzda3hgvpstyfssllm 572 14 : : : work_av4lzmkbbzda3hgvpstyfssllm 572 15 leader leader NN work_av4lzmkbbzda3hgvpstyfssllm 572 16 peptides peptide NNS work_av4lzmkbbzda3hgvpstyfssllm 572 17 cleaved cleave VBN work_av4lzmkbbzda3hgvpstyfssllm 572 18 by by IN work_av4lzmkbbzda3hgvpstyfssllm 572 19 two two CD work_av4lzmkbbzda3hgvpstyfssllm 572 20 matrix matrix NN work_av4lzmkbbzda3hgvpstyfssllm 572 21 proteases protease NNS work_av4lzmkbbzda3hgvpstyfssllm 572 22 share share VBP work_av4lzmkbbzda3hgvpstyfssllm 572 23 a a DT work_av4lzmkbbzda3hgvpstyfssllm 572 24 three three CD work_av4lzmkbbzda3hgvpstyfssllm 572 25 - - HYPH work_av4lzmkbbzda3hgvpstyfssllm 572 26 amino amino NN work_av4lzmkbbzda3hgvpstyfssllm 572 27 acid acid JJ work_av4lzmkbbzda3hgvpstyfssllm 572 28 motif motif NN work_av4lzmkbbzda3hgvpstyfssllm 572 29 . . . work_av4lzmkbbzda3hgvpstyfssllm 573 1 Proc Proc NNP work_av4lzmkbbzda3hgvpstyfssllm 573 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 574 1 Natl Natl NNP work_av4lzmkbbzda3hgvpstyfssllm 574 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 575 1 Acad Acad NNS work_av4lzmkbbzda3hgvpstyfssllm 575 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 576 1 Sci Sci NNP work_av4lzmkbbzda3hgvpstyfssllm 576 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 577 1 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 577 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 578 1 86:4056–4060 86:4056–4060 CD work_av4lzmkbbzda3hgvpstyfssllm 578 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 579 1 41 41 CD work_av4lzmkbbzda3hgvpstyfssllm 579 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 580 1 Nolt Nolt NNP work_av4lzmkbbzda3hgvpstyfssllm 580 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 580 3 S.M. S.M. NNP work_av4lzmkbbzda3hgvpstyfssllm 581 1 1992 1992 CD work_av4lzmkbbzda3hgvpstyfssllm 581 2 . . . work_av4lzmkbbzda3hgvpstyfssllm 582 1 A a DT work_av4lzmkbbzda3hgvpstyfssllm 582 2 history history NN work_av4lzmkbbzda3hgvpstyfssllm 582 3 of of IN work_av4lzmkbbzda3hgvpstyfssllm 582 4 the the DT work_av4lzmkbbzda3hgvpstyfssllm 582 5 Amish Amish NNP work_av4lzmkbbzda3hgvpstyfssllm 582 6 . . . work_av4lzmkbbzda3hgvpstyfssllm 583 1 Good Good NNP work_av4lzmkbbzda3hgvpstyfssllm 583 2 Books Books NNPS work_av4lzmkbbzda3hgvpstyfssllm 583 3 . . . work_av4lzmkbbzda3hgvpstyfssllm 584 1 Intercourse Intercourse NNP work_av4lzmkbbzda3hgvpstyfssllm 584 2 , , , work_av4lzmkbbzda3hgvpstyfssllm 584 3 Penn- Penn- NNP work_av4lzmkbbzda3hgvpstyfssllm 584 4 sylvania sylvania NNP work_av4lzmkbbzda3hgvpstyfssllm 584 5 , , , work_av4lzmkbbzda3hgvpstyfssllm 584 6 USA USA NNP work_av4lzmkbbzda3hgvpstyfssllm 584 7 . . . work_av4lzmkbbzda3hgvpstyfssllm 585 1 318 318 CD work_av4lzmkbbzda3hgvpstyfssllm 585 2 pp pp NNP work_av4lzmkbbzda3hgvpstyfssllm 585 3 . . .