id sid tid token lemma pos work_j7kpdr5srze47kmsl2scd6h4c4 1 1 untitled untitled JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 2 Noradrenergic Noradrenergic NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 3 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 4 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 1 5 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 1 6 impaired impair VBN work_j7kpdr5srze47kmsl2scd6h4c4 1 7 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 1 8 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 1 9 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 1 10 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 1 11 proneural proneural JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 12 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 13 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 1 14 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 1 15 congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 16 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 17 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 1 18 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 1 19 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 20 Ondine Ondine NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 21 ’s ’s POS work_j7kpdr5srze47kmsl2scd6h4c4 1 22 curse curse NN work_j7kpdr5srze47kmsl2scd6h4c4 1 23 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 24 Loı̈c loı̈c JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 25 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 26 Pontual Pontual NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 27 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 29 { { -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 31 Virginie Virginie NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 32 Népote Népote NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 33 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 34 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 35 { { -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 36 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 37 Tania Tania NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 38 Attié-Bitach Attié-Bitach NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 39 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 40 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 41 { { -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 42 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 43 Hassan Hassan NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 44 Al Al NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 45 Halabiah Halabiah NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 46 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 47 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 48 Ha Ha NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 49 Trang Trang NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 50 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 51 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 52 Vincent Vincent NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 53 Elghouzzi Elghouzzi NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 54 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 55 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 56 Béatrice Béatrice NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 57 Levacher Levacher NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 58 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 59 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 60 Karim Karim NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 61 Benihoud Benihoud NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 62 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 63 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 64 Joëlle Joëlle NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 65 Augé augé NN work_j7kpdr5srze47kmsl2scd6h4c4 1 66 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 67 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 68 Christophe Christophe NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 69 Faure2 Faure2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 70 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 71 Béatrice Béatrice NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 72 Laudier1 Laudier1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 73 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 74 Michel Michel NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 75 Vekemans1 Vekemans1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 76 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 77 Arnold Arnold NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 78 Munnich1 Munnich1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 79 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 80 Michel Michel NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 81 Perricaudet Perricaudet NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 82 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 83 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 84 François François NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 85 Guillemot Guillemot NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 86 4 4 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 87 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 88 Claude Claude NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 89 Gaultier Gaultier NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 90 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 91 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 92 Stanislas Stanislas NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 93 Lyonnet Lyonnet NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 94 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 95 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 96 Michel Michel NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 97 Simonneau Simonneau NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 98 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 99 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 1 100 Jeanne Jeanne NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 101 Amiel Amiel NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 102 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 103 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 104 * * NFP work_j7kpdr5srze47kmsl2scd6h4c4 1 105 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 106 Unité unité CD work_j7kpdr5srze47kmsl2scd6h4c4 1 107 de de FW work_j7kpdr5srze47kmsl2scd6h4c4 1 108 Recherches Recherches NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 109 sur sur FW work_j7kpdr5srze47kmsl2scd6h4c4 1 110 les les NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 111 Handicaps Handicaps NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 112 Génétiques génétique NNS work_j7kpdr5srze47kmsl2scd6h4c4 1 113 de de IN work_j7kpdr5srze47kmsl2scd6h4c4 1 114 l’Enfant l’Enfant NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 115 INSERM INSERM NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 116 U-393 U-393 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 117 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 118 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 1 119 Département Département NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 120 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 121 Génétique Génétique NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 122 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 123 Hôpital Hôpital VBD work_j7kpdr5srze47kmsl2scd6h4c4 1 124 Necker Necker NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 125 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 1 126 Enfants Enfants NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 127 Malades Malades NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 128 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 129 Paris Paris NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 130 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 131 France France NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 132 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 133 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 134 Service Service NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 135 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 136 Physiologie Physiologie NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 137 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 138 INSERM INSERM NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 139 E9935 E9935 NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 140 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 141 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 1 142 CIC CIC NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 143 INSERM INSERM NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 144 9202 9202 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 145 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 146 Hôpital hôpital JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 147 Robert Robert NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 148 Debré Debré NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 149 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 150 Paris Paris NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 151 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 152 France France NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 153 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 154 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 155 UMR UMR NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 156 1582 1582 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 157 CNRS CNRS NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 158 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 159 IGR IGR NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 160 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 161 Villejuif Villejuif NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 162 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 163 France France NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 164 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 1 165 4 4 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 166 NIMR NIMR NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 167 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 168 Mill Mill NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 169 Hill Hill NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 170 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 171 UK UK NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 172 Received receive VBD work_j7kpdr5srze47kmsl2scd6h4c4 1 173 August August NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 174 28 28 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 175 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 176 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 177 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 1 178 Revised revised JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 179 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 1 180 Accepted Accepted NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 181 September September NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 182 30 30 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 183 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 184 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 1 185 Congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 186 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 187 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 1 188 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 1 189 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 190 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 191 , , , work_j7kpdr5srze47kmsl2scd6h4c4 1 192 Ondine Ondine NNP work_j7kpdr5srze47kmsl2scd6h4c4 1 193 ’s ’s POS work_j7kpdr5srze47kmsl2scd6h4c4 1 194 curse curse NN work_j7kpdr5srze47kmsl2scd6h4c4 1 195 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 1 196 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 1 197 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 1 198 rare rare JJ work_j7kpdr5srze47kmsl2scd6h4c4 1 199 disorder disorder NN work_j7kpdr5srze47kmsl2scd6h4c4 1 200 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 1 201 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 1 202 chemical chemical NN work_j7kpdr5srze47kmsl2scd6h4c4 1 203 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 1 204 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 1 205 breathing breathe VBG work_j7kpdr5srze47kmsl2scd6h4c4 1 206 . . . work_j7kpdr5srze47kmsl2scd6h4c4 2 1 It -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 2 2 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 2 3 frequently frequently RB work_j7kpdr5srze47kmsl2scd6h4c4 2 4 associated associate VBN work_j7kpdr5srze47kmsl2scd6h4c4 2 5 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 2 6 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 2 7 broad broad JJ work_j7kpdr5srze47kmsl2scd6h4c4 2 8 spectrum spectrum NN work_j7kpdr5srze47kmsl2scd6h4c4 2 9 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 2 10 dysautonomic dysautonomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 2 11 symptoms symptom NNS work_j7kpdr5srze47kmsl2scd6h4c4 2 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 2 13 suggesting suggest VBG work_j7kpdr5srze47kmsl2scd6h4c4 2 14 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 2 15 involvement involvement NN work_j7kpdr5srze47kmsl2scd6h4c4 2 16 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 2 17 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 2 18 widely widely RB work_j7kpdr5srze47kmsl2scd6h4c4 2 19 expressed express VBD work_j7kpdr5srze47kmsl2scd6h4c4 2 20 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 2 21 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 2 22 autonomic autonomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 2 23 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 2 24 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 2 25 . . . work_j7kpdr5srze47kmsl2scd6h4c4 3 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 3 2 particular particular JJ work_j7kpdr5srze47kmsl2scd6h4c4 3 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 3 4 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 3 5 HASH-1–PHOX2A HASH-1–PHOX2A NNP work_j7kpdr5srze47kmsl2scd6h4c4 3 6 – – : work_j7kpdr5srze47kmsl2scd6h4c4 3 7 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 3 8 developmental developmental JJ work_j7kpdr5srze47kmsl2scd6h4c4 3 9 cascade cascade NN work_j7kpdr5srze47kmsl2scd6h4c4 3 10 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 3 11 proposed propose VBN work_j7kpdr5srze47kmsl2scd6h4c4 3 12 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 3 13 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 3 14 candidate candidate NN work_j7kpdr5srze47kmsl2scd6h4c4 3 15 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 3 16 because because IN work_j7kpdr5srze47kmsl2scd6h4c4 3 17 it -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 3 18 controls control VBZ work_j7kpdr5srze47kmsl2scd6h4c4 3 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 3 20 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 3 21 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 3 22 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 3 23 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 3 24 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 3 25 definitive definitive JJ work_j7kpdr5srze47kmsl2scd6h4c4 3 26 or or CC work_j7kpdr5srze47kmsl2scd6h4c4 3 27 transient transient JJ work_j7kpdr5srze47kmsl2scd6h4c4 3 28 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 3 29 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 3 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 3 31 upstream upstream RB work_j7kpdr5srze47kmsl2scd6h4c4 3 32 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 3 33 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 3 34 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 3 35 receptor receptor NN work_j7kpdr5srze47kmsl2scd6h4c4 3 36 tyrosine tyrosine NN work_j7kpdr5srze47kmsl2scd6h4c4 3 37 kinase kinase NN work_j7kpdr5srze47kmsl2scd6h4c4 3 38 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 3 39 tyrosine tyrosine NN work_j7kpdr5srze47kmsl2scd6h4c4 3 40 hydroxylase hydroxylase NN work_j7kpdr5srze47kmsl2scd6h4c4 3 41 . . . work_j7kpdr5srze47kmsl2scd6h4c4 4 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 4 2 recently recently RB work_j7kpdr5srze47kmsl2scd6h4c4 4 3 showed show VBD work_j7kpdr5srze47kmsl2scd6h4c4 4 4 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 4 5 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 4 6 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 4 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 4 8 major major JJ work_j7kpdr5srze47kmsl2scd6h4c4 4 9 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 4 10 locus locus NN work_j7kpdr5srze47kmsl2scd6h4c4 4 11 , , , work_j7kpdr5srze47kmsl2scd6h4c4 4 12 whose whose WP$ work_j7kpdr5srze47kmsl2scd6h4c4 4 13 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 4 14 accounts account VBZ work_j7kpdr5srze47kmsl2scd6h4c4 4 15 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 4 16 60 60 CD work_j7kpdr5srze47kmsl2scd6h4c4 4 17 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 4 18 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 4 19 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 4 20 . . . work_j7kpdr5srze47kmsl2scd6h4c4 5 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 5 2 also also RB work_j7kpdr5srze47kmsl2scd6h4c4 5 3 studied study VBD work_j7kpdr5srze47kmsl2scd6h4c4 5 4 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 5 5 proneural proneural JJ work_j7kpdr5srze47kmsl2scd6h4c4 5 6 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 5 7 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 5 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 5 9 identified identify VBD work_j7kpdr5srze47kmsl2scd6h4c4 5 10 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 5 11 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 5 12 nucleotide nucleotide JJ work_j7kpdr5srze47kmsl2scd6h4c4 5 13 substitution substitution NN work_j7kpdr5srze47kmsl2scd6h4c4 5 14 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 5 15 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 5 16 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 5 17 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 5 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 6 1 To to TO work_j7kpdr5srze47kmsl2scd6h4c4 6 2 analyze analyze VB work_j7kpdr5srze47kmsl2scd6h4c4 6 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 6 4 functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 6 5 consequences consequence NNS work_j7kpdr5srze47kmsl2scd6h4c4 6 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 6 7 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 8 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 6 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 6 10 we -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 6 11 developed develop VBD work_j7kpdr5srze47kmsl2scd6h4c4 6 12 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 6 13 in in FW work_j7kpdr5srze47kmsl2scd6h4c4 6 14 vitro vitro FW work_j7kpdr5srze47kmsl2scd6h4c4 6 15 model model NN work_j7kpdr5srze47kmsl2scd6h4c4 6 16 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 6 17 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 6 18 differentiation differentiation NN work_j7kpdr5srze47kmsl2scd6h4c4 6 19 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 6 20 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 6 21 progenitors progenitor NNS work_j7kpdr5srze47kmsl2scd6h4c4 6 22 derived derive VBN work_j7kpdr5srze47kmsl2scd6h4c4 6 23 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 6 24 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 6 25 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 6 26 vagal vagal NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 27 neural neural NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 28 crest crest NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 29 , , , work_j7kpdr5srze47kmsl2scd6h4c4 6 30 reproducing reproduce VBG work_j7kpdr5srze47kmsl2scd6h4c4 6 31 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 6 32 vitro vitro FW work_j7kpdr5srze47kmsl2scd6h4c4 6 33 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 6 34 HASH HASH NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 35 – – : work_j7kpdr5srze47kmsl2scd6h4c4 6 36 PHOX PHOX NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 37 – – : work_j7kpdr5srze47kmsl2scd6h4c4 6 38 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 6 39 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 6 40 . . . work_j7kpdr5srze47kmsl2scd6h4c4 7 1 All all DT work_j7kpdr5srze47kmsl2scd6h4c4 7 2 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 7 3 mutant mutant NN work_j7kpdr5srze47kmsl2scd6h4c4 7 4 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 7 5 impaired impair VBD work_j7kpdr5srze47kmsl2scd6h4c4 7 6 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 7 7 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 7 8 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 7 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 7 10 when when WRB work_j7kpdr5srze47kmsl2scd6h4c4 7 11 overexpressed overexpresse VBN work_j7kpdr5srze47kmsl2scd6h4c4 7 12 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 7 13 adenoviral adenoviral JJ work_j7kpdr5srze47kmsl2scd6h4c4 7 14 constructs construct NNS work_j7kpdr5srze47kmsl2scd6h4c4 7 15 . . . work_j7kpdr5srze47kmsl2scd6h4c4 8 1 Thus thus RB work_j7kpdr5srze47kmsl2scd6h4c4 8 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 8 3 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 8 4 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 8 5 may may MD work_j7kpdr5srze47kmsl2scd6h4c4 8 6 contribute contribute VB work_j7kpdr5srze47kmsl2scd6h4c4 8 7 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 8 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 8 9 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 8 10 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 8 11 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 8 12 rare rare JJ work_j7kpdr5srze47kmsl2scd6h4c4 8 13 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 8 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 8 15 consistent consistent JJ work_j7kpdr5srze47kmsl2scd6h4c4 8 16 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 8 17 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 8 18 view view NN work_j7kpdr5srze47kmsl2scd6h4c4 8 19 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 8 20 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 8 21 abnormal abnormal JJ work_j7kpdr5srze47kmsl2scd6h4c4 8 22 chemical chemical NN work_j7kpdr5srze47kmsl2scd6h4c4 8 23 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 8 24 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 8 25 breathing breathing NN work_j7kpdr5srze47kmsl2scd6h4c4 8 26 observed observe VBN work_j7kpdr5srze47kmsl2scd6h4c4 8 27 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 8 28 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 8 29 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 8 30 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 8 31 due due JJ work_j7kpdr5srze47kmsl2scd6h4c4 8 32 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 8 33 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 8 34 impairment impairment NN work_j7kpdr5srze47kmsl2scd6h4c4 8 35 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 8 36 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 8 37 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 8 38 during during IN work_j7kpdr5srze47kmsl2scd6h4c4 8 39 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 8 40 steps step NNS work_j7kpdr5srze47kmsl2scd6h4c4 8 41 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 8 42 brainstem brainstem NN work_j7kpdr5srze47kmsl2scd6h4c4 8 43 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 8 44 . . . work_j7kpdr5srze47kmsl2scd6h4c4 9 1 INTRODUCTION introduction NN work_j7kpdr5srze47kmsl2scd6h4c4 9 2 Congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 9 3 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 9 4 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 9 5 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 9 6 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 9 7 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 9 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 9 9 Ondine Ondine NNP work_j7kpdr5srze47kmsl2scd6h4c4 9 10 ’s ’s POS work_j7kpdr5srze47kmsl2scd6h4c4 9 11 curse curse NN work_j7kpdr5srze47kmsl2scd6h4c4 9 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 9 13 MIM MIM NNP work_j7kpdr5srze47kmsl2scd6h4c4 9 14 209880 209880 CD work_j7kpdr5srze47kmsl2scd6h4c4 9 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 9 16 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 9 17 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 9 18 life life NN work_j7kpdr5srze47kmsl2scd6h4c4 9 19 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 9 20 threatening threaten VBG work_j7kpdr5srze47kmsl2scd6h4c4 9 21 disorder disorder NN work_j7kpdr5srze47kmsl2scd6h4c4 9 22 characterized characterize VBN work_j7kpdr5srze47kmsl2scd6h4c4 9 23 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 9 24 persistent persistent JJ work_j7kpdr5srze47kmsl2scd6h4c4 9 25 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 9 26 during during IN work_j7kpdr5srze47kmsl2scd6h4c4 9 27 sleep sleep NN work_j7kpdr5srze47kmsl2scd6h4c4 9 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 9 29 beginning begin VBG work_j7kpdr5srze47kmsl2scd6h4c4 9 30 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 9 31 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 9 32 neonatal neonatal JJ work_j7kpdr5srze47kmsl2scd6h4c4 9 33 period period NN work_j7kpdr5srze47kmsl2scd6h4c4 9 34 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 9 35 requiring require VBG work_j7kpdr5srze47kmsl2scd6h4c4 9 36 life life NN work_j7kpdr5srze47kmsl2scd6h4c4 9 37 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 9 38 long long JJ work_j7kpdr5srze47kmsl2scd6h4c4 9 39 ventilatory ventilatory NN work_j7kpdr5srze47kmsl2scd6h4c4 9 40 assistance assistance NN work_j7kpdr5srze47kmsl2scd6h4c4 9 41 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 9 42 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 9 43 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 9 44 . . . work_j7kpdr5srze47kmsl2scd6h4c4 10 1 While while IN work_j7kpdr5srze47kmsl2scd6h4c4 10 2 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 10 3 pathophysiologic pathophysiologic JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 4 mechanisms mechanism NNS work_j7kpdr5srze47kmsl2scd6h4c4 10 5 underlying underlie VBG work_j7kpdr5srze47kmsl2scd6h4c4 10 6 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 10 7 remain remain VBP work_j7kpdr5srze47kmsl2scd6h4c4 10 8 elusive elusive JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 10 10 several several JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 11 lines line NNS work_j7kpdr5srze47kmsl2scd6h4c4 10 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 10 13 evidence evidence NN work_j7kpdr5srze47kmsl2scd6h4c4 10 14 suggest suggest VBP work_j7kpdr5srze47kmsl2scd6h4c4 10 15 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 10 16 genetic genetic JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 17 factors factor NNS work_j7kpdr5srze47kmsl2scd6h4c4 10 18 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 10 19 involved involve VBN work_j7kpdr5srze47kmsl2scd6h4c4 10 20 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 10 21 occurrence occurrence NN work_j7kpdr5srze47kmsl2scd6h4c4 10 22 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 10 23 siblings siblings NNP work_j7kpdr5srze47kmsl2scd6h4c4 10 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 10 25 concordant concordant NN work_j7kpdr5srze47kmsl2scd6h4c4 10 26 monozygotic monozygotic JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 27 twins twin NNS work_j7kpdr5srze47kmsl2scd6h4c4 10 28 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 10 29 rare rare JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 30 vertical vertical JJ work_j7kpdr5srze47kmsl2scd6h4c4 10 31 transmission transmission NN work_j7kpdr5srze47kmsl2scd6h4c4 10 32 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 10 33 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 10 34 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 10 35 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 10 36 . . . work_j7kpdr5srze47kmsl2scd6h4c4 11 1 Changes change NNS work_j7kpdr5srze47kmsl2scd6h4c4 11 2 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 11 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 11 4 integration integration NN work_j7kpdr5srze47kmsl2scd6h4c4 11 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 11 6 afferent afferent NN work_j7kpdr5srze47kmsl2scd6h4c4 11 7 inputs input NNS work_j7kpdr5srze47kmsl2scd6h4c4 11 8 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 11 9 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 11 10 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 11 11 peripheral peripheral JJ work_j7kpdr5srze47kmsl2scd6h4c4 11 12 chemoreceptors chemoreceptor NNS work_j7kpdr5srze47kmsl2scd6h4c4 11 13 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 11 14 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 11 15 brainstem brainstem NN work_j7kpdr5srze47kmsl2scd6h4c4 11 16 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 11 17 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 11 18 most most RBS work_j7kpdr5srze47kmsl2scd6h4c4 11 19 likely likely JJ work_j7kpdr5srze47kmsl2scd6h4c4 11 20 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 11 21 mechanisms mechanism NNS work_j7kpdr5srze47kmsl2scd6h4c4 11 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 12 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 12 2 addition addition NN work_j7kpdr5srze47kmsl2scd6h4c4 12 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 12 4 most most JJS work_j7kpdr5srze47kmsl2scd6h4c4 12 5 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 12 6 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 12 7 present present VBP work_j7kpdr5srze47kmsl2scd6h4c4 12 8 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 12 9 broader broad JJR work_j7kpdr5srze47kmsl2scd6h4c4 12 10 defect defect NN work_j7kpdr5srze47kmsl2scd6h4c4 12 11 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 12 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 12 13 autonomic autonomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 12 14 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 12 15 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 12 16 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 12 17 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 12 18 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 12 19 , , , work_j7kpdr5srze47kmsl2scd6h4c4 12 20 including include VBG work_j7kpdr5srze47kmsl2scd6h4c4 12 21 Hirschsprung Hirschsprung NNP work_j7kpdr5srze47kmsl2scd6h4c4 12 22 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 12 23 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 12 24 25–30 25–30 NNP work_j7kpdr5srze47kmsl2scd6h4c4 12 25 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 12 26 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 12 27 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 12 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 12 29 Haddad Haddad NNP work_j7kpdr5srze47kmsl2scd6h4c4 12 30 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 12 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 12 32 MIM MIM NNP work_j7kpdr5srze47kmsl2scd6h4c4 12 33 209880 209880 CD work_j7kpdr5srze47kmsl2scd6h4c4 12 34 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 12 35 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 12 36 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 12 37 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 12 38 , , , work_j7kpdr5srze47kmsl2scd6h4c4 12 39 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 12 40 malformation malformation NN work_j7kpdr5srze47kmsl2scd6h4c4 12 41 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 12 42 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 12 43 enteric enteric JJ work_j7kpdr5srze47kmsl2scd6h4c4 12 44 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 12 45 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 12 46 that that WDT work_j7kpdr5srze47kmsl2scd6h4c4 12 47 has have VBZ work_j7kpdr5srze47kmsl2scd6h4c4 12 48 been be VBN work_j7kpdr5srze47kmsl2scd6h4c4 12 49 ascribed ascribe VBN work_j7kpdr5srze47kmsl2scd6h4c4 12 50 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 12 51 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 12 52 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 12 53 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 12 54 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 12 55 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 12 56 receptor receptor NN work_j7kpdr5srze47kmsl2scd6h4c4 12 57 tyrosine tyrosine NN work_j7kpdr5srze47kmsl2scd6h4c4 12 58 kinase kinase NN work_j7kpdr5srze47kmsl2scd6h4c4 12 59 locus locus NN work_j7kpdr5srze47kmsl2scd6h4c4 12 60 . . . work_j7kpdr5srze47kmsl2scd6h4c4 13 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 13 2 mice mouse NNS work_j7kpdr5srze47kmsl2scd6h4c4 13 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 4 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 13 5 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 6 signaling signal VBG work_j7kpdr5srze47kmsl2scd6h4c4 13 7 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 13 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 9 which which WDT work_j7kpdr5srze47kmsl2scd6h4c4 13 10 involves involve VBZ work_j7kpdr5srze47kmsl2scd6h4c4 13 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 13 12 sequential sequential JJ work_j7kpdr5srze47kmsl2scd6h4c4 13 13 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 13 14 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 13 15 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 13 16 Mash1 mash1 NN work_j7kpdr5srze47kmsl2scd6h4c4 13 17 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 18 Phox Phox NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 19 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 20 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 21 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 13 22 TH TH NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 23 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 13 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 25 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 13 26 responsible responsible JJ work_j7kpdr5srze47kmsl2scd6h4c4 13 27 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 13 28 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 13 29 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 13 30 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 13 31 all all DT work_j7kpdr5srze47kmsl2scd6h4c4 13 32 * * NFP work_j7kpdr5srze47kmsl2scd6h4c4 13 33 To to IN work_j7kpdr5srze47kmsl2scd6h4c4 13 34 whom whom WP work_j7kpdr5srze47kmsl2scd6h4c4 13 35 correspondence correspondence NN work_j7kpdr5srze47kmsl2scd6h4c4 13 36 should should MD work_j7kpdr5srze47kmsl2scd6h4c4 13 37 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 13 38 addressed address VBN work_j7kpdr5srze47kmsl2scd6h4c4 13 39 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 13 40 : : : work_j7kpdr5srze47kmsl2scd6h4c4 13 41 Département Département NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 42 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 43 Génétique Génétique NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 44 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 45 Hôpital Hôpital VBD work_j7kpdr5srze47kmsl2scd6h4c4 13 46 Necker Necker NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 47 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 13 48 Enfants Enfants NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 49 Malades Malades NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 50 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 51 149 149 CD work_j7kpdr5srze47kmsl2scd6h4c4 13 52 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 53 rue rue FW work_j7kpdr5srze47kmsl2scd6h4c4 13 54 de de FW work_j7kpdr5srze47kmsl2scd6h4c4 13 55 Sèvres sèvre NNS work_j7kpdr5srze47kmsl2scd6h4c4 13 56 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 57 75743 75743 CD work_j7kpdr5srze47kmsl2scd6h4c4 13 58 Paris Paris NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 59 cedex cedex NN work_j7kpdr5srze47kmsl2scd6h4c4 13 60 15 15 CD work_j7kpdr5srze47kmsl2scd6h4c4 13 61 , , , work_j7kpdr5srze47kmsl2scd6h4c4 13 62 France France NNP work_j7kpdr5srze47kmsl2scd6h4c4 13 63 . . . work_j7kpdr5srze47kmsl2scd6h4c4 14 1 Tel tel NN work_j7kpdr5srze47kmsl2scd6h4c4 14 2 : : : work_j7kpdr5srze47kmsl2scd6h4c4 14 3 þ33 þ33 CD work_j7kpdr5srze47kmsl2scd6h4c4 14 4 144495648 144495648 CD work_j7kpdr5srze47kmsl2scd6h4c4 14 5 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 14 6 Fax fax NN work_j7kpdr5srze47kmsl2scd6h4c4 14 7 : : : work_j7kpdr5srze47kmsl2scd6h4c4 14 8 þ33 þ33 NNP work_j7kpdr5srze47kmsl2scd6h4c4 14 9 144495150 144495150 CD work_j7kpdr5srze47kmsl2scd6h4c4 14 10 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 14 11 Email email NN work_j7kpdr5srze47kmsl2scd6h4c4 14 12 : : : work_j7kpdr5srze47kmsl2scd6h4c4 14 13 amiel@necker.fr amiel@necker.fr DT work_j7kpdr5srze47kmsl2scd6h4c4 14 14 { { -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 14 15 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 14 16 authors author NNS work_j7kpdr5srze47kmsl2scd6h4c4 14 17 wish wish VBP work_j7kpdr5srze47kmsl2scd6h4c4 14 18 it -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 14 19 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 14 20 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 14 21 known know VBN work_j7kpdr5srze47kmsl2scd6h4c4 14 22 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 14 23 , , , work_j7kpdr5srze47kmsl2scd6h4c4 14 24 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 14 25 their -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 14 26 opinion opinion NN work_j7kpdr5srze47kmsl2scd6h4c4 14 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 14 28 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 14 29 first first JJ work_j7kpdr5srze47kmsl2scd6h4c4 14 30 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 14 31 authors author NNS work_j7kpdr5srze47kmsl2scd6h4c4 14 32 should should MD work_j7kpdr5srze47kmsl2scd6h4c4 14 33 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 14 34 regarded regard VBN work_j7kpdr5srze47kmsl2scd6h4c4 14 35 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 14 36 joint joint JJ work_j7kpdr5srze47kmsl2scd6h4c4 14 37 First First NNP work_j7kpdr5srze47kmsl2scd6h4c4 14 38 Authors Authors NNPS work_j7kpdr5srze47kmsl2scd6h4c4 14 39 . . . work_j7kpdr5srze47kmsl2scd6h4c4 15 1 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 15 2 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 15 3 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 15 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 15 5 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 15 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 15 7 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 15 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 16 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 16 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 16 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 16 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 17 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 17 2 3173–3180 3173–3180 CD work_j7kpdr5srze47kmsl2scd6h4c4 17 3 DOI doi NN work_j7kpdr5srze47kmsl2scd6h4c4 17 4 : : : work_j7kpdr5srze47kmsl2scd6h4c4 17 5 10.1093 10.1093 CD work_j7kpdr5srze47kmsl2scd6h4c4 17 6 / / SYM work_j7kpdr5srze47kmsl2scd6h4c4 17 7 hmg hmg NNP work_j7kpdr5srze47kmsl2scd6h4c4 17 8 / / SYM work_j7kpdr5srze47kmsl2scd6h4c4 17 9 ddg339 ddg339 NNP work_j7kpdr5srze47kmsl2scd6h4c4 17 10 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 17 11 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 17 12 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 17 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 17 14 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 17 15 . . . work_j7kpdr5srze47kmsl2scd6h4c4 18 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 18 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 18 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 18 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 19 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 2 # # $ work_j7kpdr5srze47kmsl2scd6h4c4 19 3 Oxford Oxford NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 4 University University NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 5 Press Press NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 6 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 7 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 19 8 all all DT work_j7kpdr5srze47kmsl2scd6h4c4 19 9 rights right NNS work_j7kpdr5srze47kmsl2scd6h4c4 19 10 reserved reserve VBD work_j7kpdr5srze47kmsl2scd6h4c4 19 11 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 19 12 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 19 13 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 19 14 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 19 15 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 19 16 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 19 17 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 19 18 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 19 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 20 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 21 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 19 22 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 19 23 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 19 24 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 19 25 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 19 26 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 19 27 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 19 28 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 19 29 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 19 30 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 31 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 32 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 33 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 34 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 35 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 36 - - : work_j7kpdr5srze47kmsl2scd6h4c4 19 37 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 19 38 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 19 39 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 40 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 19 41 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 42 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 43 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 19 44 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 19 45 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 19 46 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 47 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 48 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 49 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 50 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 51 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 52 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 19 53 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 19 54 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 55 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 19 56 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 57 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 58 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 59 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 60 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 61 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 62 , , , work_j7kpdr5srze47kmsl2scd6h4c4 19 63 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 64 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 65 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 66 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 67 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 19 68 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 19 69 : : : work_j7kpdr5srze47kmsl2scd6h4c4 19 70 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 71 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 72 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 73 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 19 74 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 75 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 76 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 77 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 78 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 19 79 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 19 80 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 19 81 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 82 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 83 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 84 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 85 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 19 86 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 87 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 19 88 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 89 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 90 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 91 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 92 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 93 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 19 94 transient transient NN work_j7kpdr5srze47kmsl2scd6h4c4 19 95 or or CC work_j7kpdr5srze47kmsl2scd6h4c4 19 96 permanent permanent JJ work_j7kpdr5srze47kmsl2scd6h4c4 19 97 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 19 98 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 19 99 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 19 100 4,5 4,5 CD work_j7kpdr5srze47kmsl2scd6h4c4 19 101 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 19 102 . . . work_j7kpdr5srze47kmsl2scd6h4c4 20 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 20 2 recently recently RB work_j7kpdr5srze47kmsl2scd6h4c4 20 3 showed show VBD work_j7kpdr5srze47kmsl2scd6h4c4 20 4 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 20 5 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 20 6 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 20 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 20 8 major major JJ work_j7kpdr5srze47kmsl2scd6h4c4 20 9 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 20 10 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 20 11 causing cause VBG work_j7kpdr5srze47kmsl2scd6h4c4 20 12 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 20 13 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 20 14 both both CC work_j7kpdr5srze47kmsl2scd6h4c4 20 15 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 20 16 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 20 17 Haddad Haddad NNP work_j7kpdr5srze47kmsl2scd6h4c4 20 18 syndromes syndrome VBZ work_j7kpdr5srze47kmsl2scd6h4c4 20 19 , , , work_j7kpdr5srze47kmsl2scd6h4c4 20 20 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 20 21 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 20 22 autosomal autosomal JJ work_j7kpdr5srze47kmsl2scd6h4c4 20 23 dominant dominant JJ work_j7kpdr5srze47kmsl2scd6h4c4 20 24 mode mode NN work_j7kpdr5srze47kmsl2scd6h4c4 20 25 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 20 26 inheritance inheritance NN work_j7kpdr5srze47kmsl2scd6h4c4 20 27 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 20 28 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 20 29 novo novo NNP work_j7kpdr5srze47kmsl2scd6h4c4 20 30 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 20 31 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 20 32 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 20 33 first first JJ work_j7kpdr5srze47kmsl2scd6h4c4 20 34 generation generation NN work_j7kpdr5srze47kmsl2scd6h4c4 20 35 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 20 36 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 20 37 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 20 38 . . . work_j7kpdr5srze47kmsl2scd6h4c4 21 1 Cross cross NN work_j7kpdr5srze47kmsl2scd6h4c4 21 2 - - NN work_j7kpdr5srze47kmsl2scd6h4c4 21 3 regulation regulation NN work_j7kpdr5srze47kmsl2scd6h4c4 21 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 21 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 21 6 Phox2 Phox2 NNS work_j7kpdr5srze47kmsl2scd6h4c4 21 7 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 21 8 Mash-1 Mash-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 21 9 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 21 10 has have VBZ work_j7kpdr5srze47kmsl2scd6h4c4 21 11 been be VBN work_j7kpdr5srze47kmsl2scd6h4c4 21 12 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 21 13 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 21 14 mice mouse NNS work_j7kpdr5srze47kmsl2scd6h4c4 21 15 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 21 16 6,7 6,7 CD work_j7kpdr5srze47kmsl2scd6h4c4 21 17 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 21 18 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 21 19 moreover moreover RB work_j7kpdr5srze47kmsl2scd6h4c4 21 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 21 21 newborn newborn JJ work_j7kpdr5srze47kmsl2scd6h4c4 21 22 Mash- Mash- NNP work_j7kpdr5srze47kmsl2scd6h4c4 21 23 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 21 24 þ/ þ/ NNP work_j7kpdr5srze47kmsl2scd6h4c4 21 25 � � JJ work_j7kpdr5srze47kmsl2scd6h4c4 21 26 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 21 27 mice mouse NNS work_j7kpdr5srze47kmsl2scd6h4c4 21 28 show show VBP work_j7kpdr5srze47kmsl2scd6h4c4 21 29 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 21 30 impaired impaired JJ work_j7kpdr5srze47kmsl2scd6h4c4 21 31 ventilatory ventilatory NN work_j7kpdr5srze47kmsl2scd6h4c4 21 32 responses response NNS work_j7kpdr5srze47kmsl2scd6h4c4 21 33 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 21 34 hypercarbia hypercarbia NNP work_j7kpdr5srze47kmsl2scd6h4c4 21 35 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 21 36 8) 8) CD work_j7kpdr5srze47kmsl2scd6h4c4 21 37 . . . work_j7kpdr5srze47kmsl2scd6h4c4 22 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 22 2 therefore therefore RB work_j7kpdr5srze47kmsl2scd6h4c4 22 3 regarded regard VBD work_j7kpdr5srze47kmsl2scd6h4c4 22 4 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 22 5 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 22 6 ortholog ortholog NN work_j7kpdr5srze47kmsl2scd6h4c4 22 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 22 8 Mash1 Mash1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 22 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 22 10 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 22 11 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 22 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 22 13 which which WDT work_j7kpdr5srze47kmsl2scd6h4c4 22 14 encodes encode VBZ work_j7kpdr5srze47kmsl2scd6h4c4 22 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 22 16 tissue tissue NN work_j7kpdr5srze47kmsl2scd6h4c4 22 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 22 18 specific specific JJ work_j7kpdr5srze47kmsl2scd6h4c4 22 19 basic basic JJ work_j7kpdr5srze47kmsl2scd6h4c4 22 20 helix helix NN work_j7kpdr5srze47kmsl2scd6h4c4 22 21 – – : work_j7kpdr5srze47kmsl2scd6h4c4 22 22 loop loop NN work_j7kpdr5srze47kmsl2scd6h4c4 22 23 – – : work_j7kpdr5srze47kmsl2scd6h4c4 22 24 helix helix NNP work_j7kpdr5srze47kmsl2scd6h4c4 22 25 transcription transcription NN work_j7kpdr5srze47kmsl2scd6h4c4 22 26 factor factor NN work_j7kpdr5srze47kmsl2scd6h4c4 22 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 22 28 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 22 29 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 22 30 additional additional JJ work_j7kpdr5srze47kmsl2scd6h4c4 22 31 candidate candidate NN work_j7kpdr5srze47kmsl2scd6h4c4 22 32 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 22 33 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 22 34 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 22 35 . . . work_j7kpdr5srze47kmsl2scd6h4c4 23 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 23 2 identified identify VBD work_j7kpdr5srze47kmsl2scd6h4c4 23 3 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 23 4 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 23 5 nucleotide nucleotide JJ work_j7kpdr5srze47kmsl2scd6h4c4 23 6 substitution substitution NN work_j7kpdr5srze47kmsl2scd6h4c4 23 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 23 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 23 9 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 23 10 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 23 11 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 23 12 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 23 13 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 23 14 . . . work_j7kpdr5srze47kmsl2scd6h4c4 24 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 24 2 functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 24 3 consequences consequence NNS work_j7kpdr5srze47kmsl2scd6h4c4 24 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 24 5 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 6 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 24 7 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 24 8 studied study VBN work_j7kpdr5srze47kmsl2scd6h4c4 24 9 using use VBG work_j7kpdr5srze47kmsl2scd6h4c4 24 10 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 24 11 novel novel NN work_j7kpdr5srze47kmsl2scd6h4c4 24 12 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 24 13 vitro vitro FW work_j7kpdr5srze47kmsl2scd6h4c4 24 14 model model NN work_j7kpdr5srze47kmsl2scd6h4c4 24 15 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 24 16 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 24 17 differentiation differentiation NN work_j7kpdr5srze47kmsl2scd6h4c4 24 18 based base VBN work_j7kpdr5srze47kmsl2scd6h4c4 24 19 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 24 20 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 24 21 progenitors progenitor NNS work_j7kpdr5srze47kmsl2scd6h4c4 24 22 derived derive VBN work_j7kpdr5srze47kmsl2scd6h4c4 24 23 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 24 24 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 24 25 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 24 26 vagal vagal NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 27 neural neural NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 28 crest crest NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 29 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 24 30 reproducing reproduce VBG work_j7kpdr5srze47kmsl2scd6h4c4 24 31 in in FW work_j7kpdr5srze47kmsl2scd6h4c4 24 32 vitro vitro FW work_j7kpdr5srze47kmsl2scd6h4c4 24 33 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 24 34 HASH HASH NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 35 – – : work_j7kpdr5srze47kmsl2scd6h4c4 24 36 PHOX PHOX NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 37 – – : work_j7kpdr5srze47kmsl2scd6h4c4 24 38 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 24 39 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 24 40 . . . work_j7kpdr5srze47kmsl2scd6h4c4 25 1 Forced force VBN work_j7kpdr5srze47kmsl2scd6h4c4 25 2 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 25 3 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 25 4 each each DT work_j7kpdr5srze47kmsl2scd6h4c4 25 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 25 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 25 7 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 25 8 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 25 9 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 25 10 induced induce VBD work_j7kpdr5srze47kmsl2scd6h4c4 25 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 25 12 impairment impairment NN work_j7kpdr5srze47kmsl2scd6h4c4 25 13 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 25 14 noradrener- noradrener- JJ work_j7kpdr5srze47kmsl2scd6h4c4 25 15 gic gic NNP work_j7kpdr5srze47kmsl2scd6h4c4 25 16 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 25 17 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 25 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 26 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 26 2 conclude conclude VBP work_j7kpdr5srze47kmsl2scd6h4c4 26 3 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 26 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 26 5 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 26 6 least least JJS work_j7kpdr5srze47kmsl2scd6h4c4 26 7 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 26 8 some some DT work_j7kpdr5srze47kmsl2scd6h4c4 26 9 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 26 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 26 11 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 26 12 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 26 13 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 26 14 may may MD work_j7kpdr5srze47kmsl2scd6h4c4 26 15 contribute contribute VB work_j7kpdr5srze47kmsl2scd6h4c4 26 16 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 26 17 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 26 18 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 26 19 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 26 20 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 26 21 modifying modify VBG work_j7kpdr5srze47kmsl2scd6h4c4 26 22 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 26 23 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 26 24 during during IN work_j7kpdr5srze47kmsl2scd6h4c4 26 25 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 26 26 steps step NNS work_j7kpdr5srze47kmsl2scd6h4c4 26 27 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 26 28 brainstem brainstem NN work_j7kpdr5srze47kmsl2scd6h4c4 26 29 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 26 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 26 31 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 26 32 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 26 33 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 26 34 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 26 35 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 26 36 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 26 37 tightly tightly RB work_j7kpdr5srze47kmsl2scd6h4c4 26 38 involved involve VBN work_j7kpdr5srze47kmsl2scd6h4c4 26 39 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 26 40 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 26 41 formation formation NN work_j7kpdr5srze47kmsl2scd6h4c4 26 42 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 26 43 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 26 44 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 26 45 network network NN work_j7kpdr5srze47kmsl2scd6h4c4 26 46 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 26 47 autonomous autonomous JJ work_j7kpdr5srze47kmsl2scd6h4c4 26 48 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 26 49 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 26 50 ventilation ventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 26 51 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 26 52 human human NN work_j7kpdr5srze47kmsl2scd6h4c4 26 53 . . . work_j7kpdr5srze47kmsl2scd6h4c4 27 1 RESULTS RESULTS NNP work_j7kpdr5srze47kmsl2scd6h4c4 27 2 HASH-1 HASH-1 VBZ work_j7kpdr5srze47kmsl2scd6h4c4 27 3 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 27 4 nucleotide nucleotide JJ work_j7kpdr5srze47kmsl2scd6h4c4 27 5 substitutions substitution NNS work_j7kpdr5srze47kmsl2scd6h4c4 27 6 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 27 7 screened screen VBD work_j7kpdr5srze47kmsl2scd6h4c4 27 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 27 9 single single JJ work_j7kpdr5srze47kmsl2scd6h4c4 27 10 coding coding NN work_j7kpdr5srze47kmsl2scd6h4c4 27 11 exon exon NNS work_j7kpdr5srze47kmsl2scd6h4c4 27 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 27 13 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 27 14 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 27 15 nucleotide nucleotide JJ work_j7kpdr5srze47kmsl2scd6h4c4 27 16 variations variation NNS work_j7kpdr5srze47kmsl2scd6h4c4 27 17 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 27 18 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 27 19 series series NN work_j7kpdr5srze47kmsl2scd6h4c4 27 20 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 27 21 30 30 CD work_j7kpdr5srze47kmsl2scd6h4c4 27 22 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 27 23 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 27 24 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 27 25 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 27 26 . . . work_j7kpdr5srze47kmsl2scd6h4c4 28 1 1 1 LS work_j7kpdr5srze47kmsl2scd6h4c4 28 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 28 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 29 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 29 2 obtained obtain VBD work_j7kpdr5srze47kmsl2scd6h4c4 29 3 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 29 4 abnormal abnormal JJ work_j7kpdr5srze47kmsl2scd6h4c4 29 5 SSCP sscp JJ work_j7kpdr5srze47kmsl2scd6h4c4 29 6 pattern pattern NN work_j7kpdr5srze47kmsl2scd6h4c4 29 7 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 29 8 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 29 9 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 29 10 . . . work_j7kpdr5srze47kmsl2scd6h4c4 30 1 Direct direct JJ work_j7kpdr5srze47kmsl2scd6h4c4 30 2 DNA DNA NNP work_j7kpdr5srze47kmsl2scd6h4c4 30 3 sequencing sequencing NN work_j7kpdr5srze47kmsl2scd6h4c4 30 4 showed show VBD work_j7kpdr5srze47kmsl2scd6h4c4 30 5 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 30 6 C c NN work_j7kpdr5srze47kmsl2scd6h4c4 30 7 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 30 8 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 30 9 transversion transversion NN work_j7kpdr5srze47kmsl2scd6h4c4 30 10 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 30 11 nucleotide nucleotide JJ work_j7kpdr5srze47kmsl2scd6h4c4 30 12 52 52 CD work_j7kpdr5srze47kmsl2scd6h4c4 30 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 30 14 resulting result VBG work_j7kpdr5srze47kmsl2scd6h4c4 30 15 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 30 16 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 30 17 proline proline NN work_j7kpdr5srze47kmsl2scd6h4c4 30 18 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 30 19 threonine threonine NN work_j7kpdr5srze47kmsl2scd6h4c4 30 20 substi- substi- JJ work_j7kpdr5srze47kmsl2scd6h4c4 30 21 tution tution NN work_j7kpdr5srze47kmsl2scd6h4c4 30 22 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 30 23 amino amino JJ work_j7kpdr5srze47kmsl2scd6h4c4 30 24 acid acid NN work_j7kpdr5srze47kmsl2scd6h4c4 30 25 position position NN work_j7kpdr5srze47kmsl2scd6h4c4 30 26 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 30 27 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 30 28 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 30 29 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 30 30 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 30 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 30 32 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 30 33 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 30 34 female female JJ work_j7kpdr5srze47kmsl2scd6h4c4 30 35 patient patient NN work_j7kpdr5srze47kmsl2scd6h4c4 30 36 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 30 37 isolated isolated JJ work_j7kpdr5srze47kmsl2scd6h4c4 30 38 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 30 39 . . . work_j7kpdr5srze47kmsl2scd6h4c4 31 1 Two two CD work_j7kpdr5srze47kmsl2scd6h4c4 31 2 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 31 3 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 31 4 frame frame NN work_j7kpdr5srze47kmsl2scd6h4c4 31 5 deletions deletion NNS work_j7kpdr5srze47kmsl2scd6h4c4 31 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 31 7 five five CD work_j7kpdr5srze47kmsl2scd6h4c4 31 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 31 9 111–125del15nt 111–125del15nt NN work_j7kpdr5srze47kmsl2scd6h4c4 31 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 31 11 A37–A41del a37–a41del LS work_j7kpdr5srze47kmsl2scd6h4c4 31 12 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 31 13 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 31 14 eight eight CD work_j7kpdr5srze47kmsl2scd6h4c4 31 15 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 31 16 108–131del24nt 108–131del24nt NNP work_j7kpdr5srze47kmsl2scd6h4c4 31 17 , , , work_j7kpdr5srze47kmsl2scd6h4c4 31 18 A36–A43del A36–A43del NNP work_j7kpdr5srze47kmsl2scd6h4c4 31 19 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 31 20 alanine alanine NN work_j7kpdr5srze47kmsl2scd6h4c4 31 21 codons codon NNS work_j7kpdr5srze47kmsl2scd6h4c4 31 22 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 31 23 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 31 24 13-residue 13-residue CD work_j7kpdr5srze47kmsl2scd6h4c4 31 25 polyalanine polyalanine NN work_j7kpdr5srze47kmsl2scd6h4c4 31 26 tract tract NN work_j7kpdr5srze47kmsl2scd6h4c4 31 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 31 28 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 31 29 identified identify VBN work_j7kpdr5srze47kmsl2scd6h4c4 31 30 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 31 31 female female JJ work_j7kpdr5srze47kmsl2scd6h4c4 31 32 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 31 33 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 31 34 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 31 35 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 31 36 Haddad Haddad NNP work_j7kpdr5srze47kmsl2scd6h4c4 31 37 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 31 38 respectively respectively RB work_j7kpdr5srze47kmsl2scd6h4c4 31 39 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 31 40 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 31 41 . . . work_j7kpdr5srze47kmsl2scd6h4c4 32 1 1A 1a LS work_j7kpdr5srze47kmsl2scd6h4c4 32 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 32 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 33 1 Both both DT work_j7kpdr5srze47kmsl2scd6h4c4 33 2 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 33 3 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 33 4 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 33 5 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 33 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 33 7 A37–A41del A37–A41del NNP work_j7kpdr5srze47kmsl2scd6h4c4 33 8 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 33 9 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 33 10 inherited inherit VBN work_j7kpdr5srze47kmsl2scd6h4c4 33 11 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 33 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 33 13 healthy healthy JJ work_j7kpdr5srze47kmsl2scd6h4c4 33 14 father father NN work_j7kpdr5srze47kmsl2scd6h4c4 33 15 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 33 16 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 33 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 34 1 1A 1a LS work_j7kpdr5srze47kmsl2scd6h4c4 34 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 34 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 34 4 while while IN work_j7kpdr5srze47kmsl2scd6h4c4 34 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 34 6 mother mother NN work_j7kpdr5srze47kmsl2scd6h4c4 34 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 34 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 34 9 patient patient NN work_j7kpdr5srze47kmsl2scd6h4c4 34 10 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 34 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 34 12 A36–A43del A36–A43del NNP work_j7kpdr5srze47kmsl2scd6h4c4 34 13 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 34 14 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 34 15 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 34 16 available available JJ work_j7kpdr5srze47kmsl2scd6h4c4 34 17 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 34 18 study study NN work_j7kpdr5srze47kmsl2scd6h4c4 34 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 35 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 35 2 HASH-1 hash-1 NN work_j7kpdr5srze47kmsl2scd6h4c4 35 3 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 35 4 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 35 5 located locate VBN work_j7kpdr5srze47kmsl2scd6h4c4 35 6 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 35 7 regions region NNS work_j7kpdr5srze47kmsl2scd6h4c4 35 8 highly highly RB work_j7kpdr5srze47kmsl2scd6h4c4 35 9 conserved conserve VBN work_j7kpdr5srze47kmsl2scd6h4c4 35 10 across across IN work_j7kpdr5srze47kmsl2scd6h4c4 35 11 mammalian mammalian JJ work_j7kpdr5srze47kmsl2scd6h4c4 35 12 ASH ASH NNP work_j7kpdr5srze47kmsl2scd6h4c4 35 13 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 35 14 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 35 15 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 35 16 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 35 17 Clustal Clustal NNP work_j7kpdr5srze47kmsl2scd6h4c4 35 18 W W NNP work_j7kpdr5srze47kmsl2scd6h4c4 35 19 analysis analysis NN work_j7kpdr5srze47kmsl2scd6h4c4 35 20 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 35 21 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 35 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 36 1 1B 1B NNP work_j7kpdr5srze47kmsl2scd6h4c4 36 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 36 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 37 1 These these DT work_j7kpdr5srze47kmsl2scd6h4c4 37 2 data datum NNS work_j7kpdr5srze47kmsl2scd6h4c4 37 3 suggest suggest VBP work_j7kpdr5srze47kmsl2scd6h4c4 37 4 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 37 5 these these DT work_j7kpdr5srze47kmsl2scd6h4c4 37 6 protein protein NN work_j7kpdr5srze47kmsl2scd6h4c4 37 7 domains domain NNS work_j7kpdr5srze47kmsl2scd6h4c4 37 8 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 37 9 functionally functionally RB work_j7kpdr5srze47kmsl2scd6h4c4 37 10 relevant relevant JJ work_j7kpdr5srze47kmsl2scd6h4c4 37 11 . . . work_j7kpdr5srze47kmsl2scd6h4c4 38 1 Accordingly accordingly RB work_j7kpdr5srze47kmsl2scd6h4c4 38 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 38 3 none none NN work_j7kpdr5srze47kmsl2scd6h4c4 38 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 38 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 38 6 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 38 7 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 38 8 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 38 9 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 38 10 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 38 11 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 38 12 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 38 13 panel panel NN work_j7kpdr5srze47kmsl2scd6h4c4 38 14 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 38 15 120 120 CD work_j7kpdr5srze47kmsl2scd6h4c4 38 16 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 38 17 chromosomes chromosome NNS work_j7kpdr5srze47kmsl2scd6h4c4 38 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 39 1 Interestingly interestingly RB work_j7kpdr5srze47kmsl2scd6h4c4 39 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 39 3 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 39 4 de de FW work_j7kpdr5srze47kmsl2scd6h4c4 39 5 novo novo NNP work_j7kpdr5srze47kmsl2scd6h4c4 39 6 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 39 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 39 8 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 39 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 39 10 polyalanine polyalanine JJ work_j7kpdr5srze47kmsl2scd6h4c4 39 11 expansion expansion NN work_j7kpdr5srze47kmsl2scd6h4c4 39 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 39 13 seven seven CD work_j7kpdr5srze47kmsl2scd6h4c4 39 14 alanines alanine NNS work_j7kpdr5srze47kmsl2scd6h4c4 39 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 39 16 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 39 17 found find VBN work_j7kpdr5srze47kmsl2scd6h4c4 39 18 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 39 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 39 20 patient patient NN work_j7kpdr5srze47kmsl2scd6h4c4 39 21 harboring harbor VBG work_j7kpdr5srze47kmsl2scd6h4c4 39 22 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 39 23 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 39 24 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 39 25 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 39 26 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 39 27 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 39 28 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 39 29 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 39 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 39 31 whereas whereas IN work_j7kpdr5srze47kmsl2scd6h4c4 39 32 direct direct JJ work_j7kpdr5srze47kmsl2scd6h4c4 39 33 sequencing sequencing NN work_j7kpdr5srze47kmsl2scd6h4c4 39 34 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 39 35 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 39 36 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 39 37 exons exon NNS work_j7kpdr5srze47kmsl2scd6h4c4 39 38 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 39 39 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 39 40 showed show VBD work_j7kpdr5srze47kmsl2scd6h4c4 39 41 no no DT work_j7kpdr5srze47kmsl2scd6h4c4 39 42 variation variation NN work_j7kpdr5srze47kmsl2scd6h4c4 39 43 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 39 44 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 39 45 other other JJ work_j7kpdr5srze47kmsl2scd6h4c4 39 46 two two CD work_j7kpdr5srze47kmsl2scd6h4c4 39 47 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 39 48 . . . work_j7kpdr5srze47kmsl2scd6h4c4 40 1 Indeed indeed RB work_j7kpdr5srze47kmsl2scd6h4c4 40 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 40 3 all all DT work_j7kpdr5srze47kmsl2scd6h4c4 40 4 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 40 5 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 40 6 described describe VBN work_j7kpdr5srze47kmsl2scd6h4c4 40 7 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 40 8 this this DT work_j7kpdr5srze47kmsl2scd6h4c4 40 9 series series NN work_j7kpdr5srze47kmsl2scd6h4c4 40 10 have have VBP work_j7kpdr5srze47kmsl2scd6h4c4 40 11 been be VBN work_j7kpdr5srze47kmsl2scd6h4c4 40 12 tested test VBN work_j7kpdr5srze47kmsl2scd6h4c4 40 13 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 40 14 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 40 15 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 40 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 40 17 GDNF GDNF NNP work_j7kpdr5srze47kmsl2scd6h4c4 40 18 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 40 19 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 40 20 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 40 21 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 40 22 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 40 23 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 40 24 . . . work_j7kpdr5srze47kmsl2scd6h4c4 41 1 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 41 2 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 41 3 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 41 4 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 41 5 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 41 6 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 41 7 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 41 8 further further RB work_j7kpdr5srze47kmsl2scd6h4c4 41 9 investigated investigate VBD work_j7kpdr5srze47kmsl2scd6h4c4 41 10 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 41 11 possible possible JJ work_j7kpdr5srze47kmsl2scd6h4c4 41 12 involvement involvement NN work_j7kpdr5srze47kmsl2scd6h4c4 41 13 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 41 14 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 41 15 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 41 16 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 41 17 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 41 18 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 41 19 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 41 20 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 41 21 studying study VBG work_j7kpdr5srze47kmsl2scd6h4c4 41 22 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 41 23 pattern pattern NN work_j7kpdr5srze47kmsl2scd6h4c4 41 24 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 41 25 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 41 26 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 41 27 HASH-1 HASH-1 NNS work_j7kpdr5srze47kmsl2scd6h4c4 41 28 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 41 29 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 41 30 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 41 31 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 41 32 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 41 33 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 41 34 . . . work_j7kpdr5srze47kmsl2scd6h4c4 42 1 2 2 LS work_j7kpdr5srze47kmsl2scd6h4c4 42 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 42 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 43 1 Consistent consistent JJ work_j7kpdr5srze47kmsl2scd6h4c4 43 2 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 43 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 43 4 wide wide JJ work_j7kpdr5srze47kmsl2scd6h4c4 43 5 spectrum spectrum NN work_j7kpdr5srze47kmsl2scd6h4c4 43 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 43 7 afferent afferent NN work_j7kpdr5srze47kmsl2scd6h4c4 43 8 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 43 9 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 43 10 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 43 11 ANS ans NN work_j7kpdr5srze47kmsl2scd6h4c4 43 12 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 43 13 dysfunction dysfunction NN work_j7kpdr5srze47kmsl2scd6h4c4 43 14 observed observe VBN work_j7kpdr5srze47kmsl2scd6h4c4 43 15 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 43 16 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 43 17 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 43 18 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 43 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 43 20 pattern pattern NN work_j7kpdr5srze47kmsl2scd6h4c4 43 21 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 43 22 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 43 23 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 43 24 mice mouse NNS work_j7kpdr5srze47kmsl2scd6h4c4 43 25 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 43 26 9,10 9,10 NN work_j7kpdr5srze47kmsl2scd6h4c4 43 27 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 43 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 43 29 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 43 30 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 43 31 expressed express VBN work_j7kpdr5srze47kmsl2scd6h4c4 43 32 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 43 33 both both CC work_j7kpdr5srze47kmsl2scd6h4c4 43 34 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 43 35 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 43 36 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 43 37 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 43 38 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 43 39 mesencephalon mesencephalon NN work_j7kpdr5srze47kmsl2scd6h4c4 43 40 , , , work_j7kpdr5srze47kmsl2scd6h4c4 43 41 rhombencephalon rhombencephalon NNP work_j7kpdr5srze47kmsl2scd6h4c4 43 42 , , , work_j7kpdr5srze47kmsl2scd6h4c4 43 43 spinal spinal JJ work_j7kpdr5srze47kmsl2scd6h4c4 43 44 cord cord NN work_j7kpdr5srze47kmsl2scd6h4c4 43 45 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 43 46 Fig Fig NNP work_j7kpdr5srze47kmsl2scd6h4c4 43 47 . . . work_j7kpdr5srze47kmsl2scd6h4c4 44 1 2A 2a LS work_j7kpdr5srze47kmsl2scd6h4c4 44 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 44 3 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 44 4 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 44 5 E E NNP work_j7kpdr5srze47kmsl2scd6h4c4 44 6 – – : work_j7kpdr5srze47kmsl2scd6h4c4 44 7 H h NN work_j7kpdr5srze47kmsl2scd6h4c4 44 8 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 44 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 44 10 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 44 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 44 12 peripheral peripheral JJ work_j7kpdr5srze47kmsl2scd6h4c4 44 13 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 44 14 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 44 15 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 44 16 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 44 17 lining line VBG work_j7kpdr5srze47kmsl2scd6h4c4 44 18 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 44 19 dorsal dorsal NN work_j7kpdr5srze47kmsl2scd6h4c4 44 20 aorta aorta NNP work_j7kpdr5srze47kmsl2scd6h4c4 44 21 , , , work_j7kpdr5srze47kmsl2scd6h4c4 44 22 presumed presume VBN work_j7kpdr5srze47kmsl2scd6h4c4 44 23 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 44 24 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 44 25 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 44 26 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 44 27 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 44 28 derived derive VBN work_j7kpdr5srze47kmsl2scd6h4c4 44 29 precursors precursor NNS work_j7kpdr5srze47kmsl2scd6h4c4 44 30 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 44 31 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 44 32 sympathetic sympathetic JJ work_j7kpdr5srze47kmsl2scd6h4c4 44 33 ganglia ganglia NN work_j7kpdr5srze47kmsl2scd6h4c4 44 34 , , , work_j7kpdr5srze47kmsl2scd6h4c4 44 35 Fig Fig NNP work_j7kpdr5srze47kmsl2scd6h4c4 44 36 . . . work_j7kpdr5srze47kmsl2scd6h4c4 45 1 2C 2c NN work_j7kpdr5srze47kmsl2scd6h4c4 45 2 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 45 3 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 45 4 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 45 5 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 45 6 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 45 7 stage stage NN work_j7kpdr5srze47kmsl2scd6h4c4 45 8 14 14 CD work_j7kpdr5srze47kmsl2scd6h4c4 45 9 . . . work_j7kpdr5srze47kmsl2scd6h4c4 46 1 At at IN work_j7kpdr5srze47kmsl2scd6h4c4 46 2 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 46 3 stage stage NN work_j7kpdr5srze47kmsl2scd6h4c4 46 4 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 46 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 46 6 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 46 7 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 46 8 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 46 9 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 46 10 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 46 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 46 12 presumptive presumptive JJ work_j7kpdr5srze47kmsl2scd6h4c4 46 13 enteric enteric JJ work_j7kpdr5srze47kmsl2scd6h4c4 46 14 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 46 15 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 46 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 46 17 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 46 18 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 46 19 esophagus esophagus NN work_j7kpdr5srze47kmsl2scd6h4c4 46 20 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 46 21 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 46 22 rectum rectum NN work_j7kpdr5srze47kmsl2scd6h4c4 46 23 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 46 24 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 46 25 . . . work_j7kpdr5srze47kmsl2scd6h4c4 47 1 2E 2e LS work_j7kpdr5srze47kmsl2scd6h4c4 47 2 – – : work_j7kpdr5srze47kmsl2scd6h4c4 47 3 H h NN work_j7kpdr5srze47kmsl2scd6h4c4 47 4 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 47 5 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 47 6 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 47 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 47 8 adrenal adrenal JJ work_j7kpdr5srze47kmsl2scd6h4c4 47 9 medulla medulla NN work_j7kpdr5srze47kmsl2scd6h4c4 47 10 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 47 11 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 47 12 . . . work_j7kpdr5srze47kmsl2scd6h4c4 48 1 2I 2I NNP work_j7kpdr5srze47kmsl2scd6h4c4 48 2 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 48 3 J J NNP work_j7kpdr5srze47kmsl2scd6h4c4 48 4 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 48 5 . . . work_j7kpdr5srze47kmsl2scd6h4c4 49 1 Functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 49 2 analysis analysis NN work_j7kpdr5srze47kmsl2scd6h4c4 49 3 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 49 4 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 49 5 mutant mutant NNP work_j7kpdr5srze47kmsl2scd6h4c4 49 6 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 49 7 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 49 8 investigated investigate VBD work_j7kpdr5srze47kmsl2scd6h4c4 49 9 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 49 10 effects effect NNS work_j7kpdr5srze47kmsl2scd6h4c4 49 11 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 49 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 49 13 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 49 14 mutated mutate VBD work_j7kpdr5srze47kmsl2scd6h4c4 49 15 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 49 16 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 49 17 their -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 49 18 transcriptional transcriptional JJ work_j7kpdr5srze47kmsl2scd6h4c4 49 19 activity activity NN work_j7kpdr5srze47kmsl2scd6h4c4 49 20 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 49 21 means mean NNS work_j7kpdr5srze47kmsl2scd6h4c4 49 22 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 49 23 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 49 24 luciferase luciferase NN work_j7kpdr5srze47kmsl2scd6h4c4 49 25 assay assay NN work_j7kpdr5srze47kmsl2scd6h4c4 49 26 . . . work_j7kpdr5srze47kmsl2scd6h4c4 50 1 P19 p19 NN work_j7kpdr5srze47kmsl2scd6h4c4 50 2 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 50 3 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 50 4 co co VBN work_j7kpdr5srze47kmsl2scd6h4c4 50 5 - - VBN work_j7kpdr5srze47kmsl2scd6h4c4 50 6 transfected transfecte VBN work_j7kpdr5srze47kmsl2scd6h4c4 50 7 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 50 8 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 50 9 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 50 10 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 50 11 þ/ þ/ NNP work_j7kpdr5srze47kmsl2scd6h4c4 50 12 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 50 13 E47 E47 NNP work_j7kpdr5srze47kmsl2scd6h4c4 50 14 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 50 15 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 50 16 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 50 17 luciferase luciferase NN work_j7kpdr5srze47kmsl2scd6h4c4 50 18 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 50 19 under under IN work_j7kpdr5srze47kmsl2scd6h4c4 50 20 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 50 21 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 50 22 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 50 23 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 50 24 Delta1 Delta1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 50 25 promoter promoter NN work_j7kpdr5srze47kmsl2scd6h4c4 50 26 . . . work_j7kpdr5srze47kmsl2scd6h4c4 51 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 51 2 transcriptional transcriptional JJ work_j7kpdr5srze47kmsl2scd6h4c4 51 3 activities activity NNS work_j7kpdr5srze47kmsl2scd6h4c4 51 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 51 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 51 6 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 51 7 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 51 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 51 9 A36-A43del a36-a43del CD work_j7kpdr5srze47kmsl2scd6h4c4 51 10 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 51 11 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 51 12 similar similar JJ work_j7kpdr5srze47kmsl2scd6h4c4 51 13 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 51 14 that that DT work_j7kpdr5srze47kmsl2scd6h4c4 51 15 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 51 16 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 51 17 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 51 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 51 19 regardless regardless RB work_j7kpdr5srze47kmsl2scd6h4c4 51 20 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 51 21 whether whether IN work_j7kpdr5srze47kmsl2scd6h4c4 51 22 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 51 23 E47 E47 NNP work_j7kpdr5srze47kmsl2scd6h4c4 51 24 cofactor cofactor NN work_j7kpdr5srze47kmsl2scd6h4c4 51 25 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 51 26 present present JJ work_j7kpdr5srze47kmsl2scd6h4c4 51 27 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 51 28 data datum NNS work_j7kpdr5srze47kmsl2scd6h4c4 51 29 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 51 30 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 51 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 51 32 available available JJ work_j7kpdr5srze47kmsl2scd6h4c4 51 33 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 51 34 request request NN work_j7kpdr5srze47kmsl2scd6h4c4 51 35 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 51 36 . . . work_j7kpdr5srze47kmsl2scd6h4c4 52 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 52 2 then then RB work_j7kpdr5srze47kmsl2scd6h4c4 52 3 overexpressed overexpresse VBD work_j7kpdr5srze47kmsl2scd6h4c4 52 4 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 52 5 wild wild JJ work_j7kpdr5srze47kmsl2scd6h4c4 52 6 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 52 7 type type NN work_j7kpdr5srze47kmsl2scd6h4c4 52 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 52 9 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 52 10 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 52 11 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 52 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 52 13 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 52 14 assessed assess VBD work_j7kpdr5srze47kmsl2scd6h4c4 52 15 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 52 16 functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 52 17 consequences consequence NNS work_j7kpdr5srze47kmsl2scd6h4c4 52 18 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 52 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 52 20 differentiation differentiation NN work_j7kpdr5srze47kmsl2scd6h4c4 52 21 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 52 22 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 52 23 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 52 24 lineage lineage NN work_j7kpdr5srze47kmsl2scd6h4c4 52 25 , , , work_j7kpdr5srze47kmsl2scd6h4c4 52 26 using use VBG work_j7kpdr5srze47kmsl2scd6h4c4 52 27 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 52 28 PHOX PHOX NNP work_j7kpdr5srze47kmsl2scd6h4c4 52 29 – – : work_j7kpdr5srze47kmsl2scd6h4c4 52 30 RET ret NN work_j7kpdr5srze47kmsl2scd6h4c4 52 31 signaling signal VBG work_j7kpdr5srze47kmsl2scd6h4c4 52 32 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 52 33 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 52 34 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 52 35 tyrosine tyrosine JJ work_j7kpdr5srze47kmsl2scd6h4c4 52 36 hydroxylase hydroxylase NN work_j7kpdr5srze47kmsl2scd6h4c4 52 37 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 52 38 TH TH NNP work_j7kpdr5srze47kmsl2scd6h4c4 52 39 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 52 40 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 52 41 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 52 42 markers marker NNS work_j7kpdr5srze47kmsl2scd6h4c4 52 43 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 52 44 11,12 11,12 CD work_j7kpdr5srze47kmsl2scd6h4c4 52 45 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 52 46 . . . work_j7kpdr5srze47kmsl2scd6h4c4 53 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 53 2 demonstrated demonstrate VBD work_j7kpdr5srze47kmsl2scd6h4c4 53 3 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 53 4 undiffer- undiffer- JJ work_j7kpdr5srze47kmsl2scd6h4c4 53 5 entiated entiate VBN work_j7kpdr5srze47kmsl2scd6h4c4 53 6 vagal vagal NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 7 neural neural NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 8 crest crest NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 9 progenitor progenitor NN work_j7kpdr5srze47kmsl2scd6h4c4 53 10 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 53 11 , , , work_j7kpdr5srze47kmsl2scd6h4c4 53 12 isolated isolate VBN work_j7kpdr5srze47kmsl2scd6h4c4 53 13 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 53 14 E9 E9 NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 15 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 53 16 embryos embryo NNS work_j7kpdr5srze47kmsl2scd6h4c4 53 17 , , , work_j7kpdr5srze47kmsl2scd6h4c4 53 18 may may MD work_j7kpdr5srze47kmsl2scd6h4c4 53 19 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 53 20 engaged engage VBN work_j7kpdr5srze47kmsl2scd6h4c4 53 21 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 53 22 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 53 23 differentia- differentia- NN work_j7kpdr5srze47kmsl2scd6h4c4 53 24 tion tion NN work_j7kpdr5srze47kmsl2scd6h4c4 53 25 , , , work_j7kpdr5srze47kmsl2scd6h4c4 53 26 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 53 27 then then RB work_j7kpdr5srze47kmsl2scd6h4c4 53 28 sequentially sequentially RB work_j7kpdr5srze47kmsl2scd6h4c4 53 29 produce produce VB work_j7kpdr5srze47kmsl2scd6h4c4 53 30 Phox2a Phox2a NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 53 32 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 53 34 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 53 35 TH TH NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 36 , , , work_j7kpdr5srze47kmsl2scd6h4c4 53 37 thereby thereby RB work_j7kpdr5srze47kmsl2scd6h4c4 53 38 reproducing reproduce VBG work_j7kpdr5srze47kmsl2scd6h4c4 53 39 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 53 40 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 53 41 Mash-1 Mash-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 53 42 molecular molecular JJ work_j7kpdr5srze47kmsl2scd6h4c4 53 43 cascade cascade NN work_j7kpdr5srze47kmsl2scd6h4c4 53 44 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 53 45 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 53 46 . . . work_j7kpdr5srze47kmsl2scd6h4c4 54 1 3A 3A NNP work_j7kpdr5srze47kmsl2scd6h4c4 54 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 54 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 55 1 Interestingly interestingly RB work_j7kpdr5srze47kmsl2scd6h4c4 55 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 55 3 no no DT work_j7kpdr5srze47kmsl2scd6h4c4 55 4 alternative alternative JJ work_j7kpdr5srze47kmsl2scd6h4c4 55 5 lineage lineage NN work_j7kpdr5srze47kmsl2scd6h4c4 55 6 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 55 7 obtained obtain VBN work_j7kpdr5srze47kmsl2scd6h4c4 55 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 55 9 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 55 10 almost almost RB work_j7kpdr5srze47kmsl2scd6h4c4 55 11 all all DT work_j7kpdr5srze47kmsl2scd6h4c4 55 12 THþ THþ NNS work_j7kpdr5srze47kmsl2scd6h4c4 55 13 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 55 14 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 55 15 derived derive VBN work_j7kpdr5srze47kmsl2scd6h4c4 55 16 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 55 17 PHOX2A PHOX2A NNP work_j7kpdr5srze47kmsl2scd6h4c4 55 18 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 55 19 expressing express VBG work_j7kpdr5srze47kmsl2scd6h4c4 55 20 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 55 21 . . . work_j7kpdr5srze47kmsl2scd6h4c4 56 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 56 2 then then RB work_j7kpdr5srze47kmsl2scd6h4c4 56 3 showed show VBD work_j7kpdr5srze47kmsl2scd6h4c4 56 4 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 56 5 it -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 56 6 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 56 7 possible possible JJ work_j7kpdr5srze47kmsl2scd6h4c4 56 8 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 56 9 reproduce reproduce VB work_j7kpdr5srze47kmsl2scd6h4c4 56 10 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 56 11 catecholaminergic catecholaminergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 56 12 differentiation differentiation NN work_j7kpdr5srze47kmsl2scd6h4c4 56 13 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 56 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 56 15 72 72 CD work_j7kpdr5srze47kmsl2scd6h4c4 56 16 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 56 17 after after IN work_j7kpdr5srze47kmsl2scd6h4c4 56 18 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 56 19 forced force VBN work_j7kpdr5srze47kmsl2scd6h4c4 56 20 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 56 21 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 56 22 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 56 23 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 56 24 recombinant recombinant JJ work_j7kpdr5srze47kmsl2scd6h4c4 56 25 adenoviruses adenovirus NNS work_j7kpdr5srze47kmsl2scd6h4c4 56 26 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 56 27 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 56 28 . . . work_j7kpdr5srze47kmsl2scd6h4c4 57 1 3B 3B NNP work_j7kpdr5srze47kmsl2scd6h4c4 57 2 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 57 3 C C NNP work_j7kpdr5srze47kmsl2scd6h4c4 57 4 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 57 5 . . . work_j7kpdr5srze47kmsl2scd6h4c4 58 1 All all PDT work_j7kpdr5srze47kmsl2scd6h4c4 58 2 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 58 3 infected infected JJ work_j7kpdr5srze47kmsl2scd6h4c4 58 4 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 58 5 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 58 6 100 100 CD work_j7kpdr5srze47kmsl2scd6h4c4 58 7 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 58 8 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 58 9 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 58 10 transduced transduce VBN work_j7kpdr5srze47kmsl2scd6h4c4 58 11 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 58 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 58 13 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 58 14 adenoviral adenoviral NN work_j7kpdr5srze47kmsl2scd6h4c4 58 15 constructs construct NNS work_j7kpdr5srze47kmsl2scd6h4c4 58 16 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 58 17 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 58 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 59 1 4 4 LS work_j7kpdr5srze47kmsl2scd6h4c4 59 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 59 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 59 4 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 59 5 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 59 6 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 59 7 GFP GFP NNP work_j7kpdr5srze47kmsl2scd6h4c4 59 8 production production NN work_j7kpdr5srze47kmsl2scd6h4c4 59 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 59 10 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 59 11 . . . work_j7kpdr5srze47kmsl2scd6h4c4 60 1 4B 4B NNP work_j7kpdr5srze47kmsl2scd6h4c4 60 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 60 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 61 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 61 2 overexpression overexpression NN work_j7kpdr5srze47kmsl2scd6h4c4 61 3 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 61 4 wild wild JJ work_j7kpdr5srze47kmsl2scd6h4c4 61 5 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 61 6 type type NN work_j7kpdr5srze47kmsl2scd6h4c4 61 7 HASH-1 HASH-1 NNS work_j7kpdr5srze47kmsl2scd6h4c4 61 8 resulted result VBD work_j7kpdr5srze47kmsl2scd6h4c4 61 9 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 61 10 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 61 11 differentiation differentiation NN work_j7kpdr5srze47kmsl2scd6h4c4 61 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 61 13 52.3 52.3 CD work_j7kpdr5srze47kmsl2scd6h4c4 61 14 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 61 15 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 61 16 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 61 17 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 61 18 n¼12 n¼12 NNP work_j7kpdr5srze47kmsl2scd6h4c4 61 19 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 61 20 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 61 21 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 61 22 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 61 23 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 61 24 into into IN work_j7kpdr5srze47kmsl2scd6h4c4 61 25 postmitotic postmitotic JJ work_j7kpdr5srze47kmsl2scd6h4c4 61 26 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 61 27 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 61 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 61 29 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 61 30 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 61 31 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 61 32 Phox2a phox2a NN work_j7kpdr5srze47kmsl2scd6h4c4 61 33 production production NN work_j7kpdr5srze47kmsl2scd6h4c4 61 34 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 61 35 data datum NNS work_j7kpdr5srze47kmsl2scd6h4c4 61 36 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 61 37 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 61 38 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 61 39 . . . work_j7kpdr5srze47kmsl2scd6h4c4 62 1 These these DT work_j7kpdr5srze47kmsl2scd6h4c4 62 2 values value NNS work_j7kpdr5srze47kmsl2scd6h4c4 62 3 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 62 4 similar similar JJ work_j7kpdr5srze47kmsl2scd6h4c4 62 5 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 62 6 those those DT work_j7kpdr5srze47kmsl2scd6h4c4 62 7 previously previously RB work_j7kpdr5srze47kmsl2scd6h4c4 62 8 reported report VBN work_j7kpdr5srze47kmsl2scd6h4c4 62 9 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 62 10 retroviral retroviral JJ work_j7kpdr5srze47kmsl2scd6h4c4 62 11 forced force VBN work_j7kpdr5srze47kmsl2scd6h4c4 62 12 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 62 13 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 62 14 11 11 CD work_j7kpdr5srze47kmsl2scd6h4c4 62 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 62 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 63 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 63 2 investigated investigate VBD work_j7kpdr5srze47kmsl2scd6h4c4 63 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 63 4 functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 63 5 consequences consequence NNS work_j7kpdr5srze47kmsl2scd6h4c4 63 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 63 7 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 63 8 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 63 9 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 63 10 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 63 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 63 12 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 63 13 lineage lineage NN work_j7kpdr5srze47kmsl2scd6h4c4 63 14 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 63 15 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 63 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 64 1 4B 4B NNP work_j7kpdr5srze47kmsl2scd6h4c4 64 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 64 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 65 1 All all DT work_j7kpdr5srze47kmsl2scd6h4c4 65 2 mutated mutate VBN work_j7kpdr5srze47kmsl2scd6h4c4 65 3 forms form NNS work_j7kpdr5srze47kmsl2scd6h4c4 65 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 65 5 HASH-1 HASH-1 NNS work_j7kpdr5srze47kmsl2scd6h4c4 65 6 tested test VBN work_j7kpdr5srze47kmsl2scd6h4c4 65 7 led lead VBD work_j7kpdr5srze47kmsl2scd6h4c4 65 8 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 65 9 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 65 10 significant significant JJ work_j7kpdr5srze47kmsl2scd6h4c4 65 11 decrease decrease NN work_j7kpdr5srze47kmsl2scd6h4c4 65 12 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 65 13 20–30 20–30 CD work_j7kpdr5srze47kmsl2scd6h4c4 65 14 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 65 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 65 16 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 65 17 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 65 18 number number NN work_j7kpdr5srze47kmsl2scd6h4c4 65 19 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 65 20 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 65 21 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 65 22 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 65 23 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 65 24 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 65 25 lineage lineage NN work_j7kpdr5srze47kmsl2scd6h4c4 65 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 65 27 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 65 28 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 65 29 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 65 30 Phox2a phox2a NN work_j7kpdr5srze47kmsl2scd6h4c4 65 31 production production NN work_j7kpdr5srze47kmsl2scd6h4c4 65 32 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 65 33 Fig fig NN work_j7kpdr5srze47kmsl2scd6h4c4 65 34 . . . work_j7kpdr5srze47kmsl2scd6h4c4 66 1 4B 4B NNP work_j7kpdr5srze47kmsl2scd6h4c4 66 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 66 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 67 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 67 2 particular particular JJ work_j7kpdr5srze47kmsl2scd6h4c4 67 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 67 4 only only RB work_j7kpdr5srze47kmsl2scd6h4c4 67 5 34.4 34.4 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 6 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 7 0.7 0.7 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 8 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 67 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 67 10 p p NN work_j7kpdr5srze47kmsl2scd6h4c4 67 11 < < XX work_j7kpdr5srze47kmsl2scd6h4c4 67 12 0.001 0.001 XX work_j7kpdr5srze47kmsl2scd6h4c4 67 13 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 67 14 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 67 15 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 67 16 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 67 17 progenitors progenitor NNS work_j7kpdr5srze47kmsl2scd6h4c4 67 18 differentiated differentiate VBN work_j7kpdr5srze47kmsl2scd6h4c4 67 19 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 67 20 give give VB work_j7kpdr5srze47kmsl2scd6h4c4 67 21 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 67 22 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 67 23 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 67 24 using use VBG work_j7kpdr5srze47kmsl2scd6h4c4 67 25 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 67 26 A37–A41del A37–A41del NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 27 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 28 mutant mutant NN work_j7kpdr5srze47kmsl2scd6h4c4 67 29 construct construct NN work_j7kpdr5srze47kmsl2scd6h4c4 67 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 67 31 whereas whereas IN work_j7kpdr5srze47kmsl2scd6h4c4 67 32 39.3 39.3 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 33 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 34 0.6 0.6 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 35 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 67 36 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 67 37 38.7 38.7 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 38 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 39 0.6 0.6 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 40 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 67 41 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 67 42 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 67 43 produced produce VBN work_j7kpdr5srze47kmsl2scd6h4c4 67 44 Phox2a phox2a IN work_j7kpdr5srze47kmsl2scd6h4c4 67 45 when when WRB work_j7kpdr5srze47kmsl2scd6h4c4 67 46 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 67 47 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 48 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 49 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 67 50 A36–A43del A36–A43del NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 51 HASH- HASH- NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 52 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 67 53 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 67 54 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 67 55 , , , work_j7kpdr5srze47kmsl2scd6h4c4 67 56 respectively respectively RB work_j7kpdr5srze47kmsl2scd6h4c4 67 57 , , , work_j7kpdr5srze47kmsl2scd6h4c4 67 58 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 67 59 used use VBN work_j7kpdr5srze47kmsl2scd6h4c4 67 60 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 67 61 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 67 62 < < XX work_j7kpdr5srze47kmsl2scd6h4c4 67 63 0.01 0.01 XX work_j7kpdr5srze47kmsl2scd6h4c4 67 64 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 67 65 Fig Fig NNP work_j7kpdr5srze47kmsl2scd6h4c4 67 66 . . . work_j7kpdr5srze47kmsl2scd6h4c4 68 1 4B 4B NNP work_j7kpdr5srze47kmsl2scd6h4c4 68 2 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 68 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 69 1 DISCUSSION DISCUSSION NNP work_j7kpdr5srze47kmsl2scd6h4c4 69 2 Taking take VBG work_j7kpdr5srze47kmsl2scd6h4c4 69 3 advantage advantage NN work_j7kpdr5srze47kmsl2scd6h4c4 69 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 69 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 69 6 well well RB work_j7kpdr5srze47kmsl2scd6h4c4 69 7 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 69 8 characterized characterize VBN work_j7kpdr5srze47kmsl2scd6h4c4 69 9 specification specification NN work_j7kpdr5srze47kmsl2scd6h4c4 69 10 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 69 11 catecholaminergic catecholaminergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 69 12 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 69 13 derived derive VBN work_j7kpdr5srze47kmsl2scd6h4c4 69 14 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 69 15 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 69 16 vagal vagal NNP work_j7kpdr5srze47kmsl2scd6h4c4 69 17 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 69 18 crest crest NNP work_j7kpdr5srze47kmsl2scd6h4c4 69 19 3174 3174 CD work_j7kpdr5srze47kmsl2scd6h4c4 69 20 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 69 21 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 69 22 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 69 23 , , , work_j7kpdr5srze47kmsl2scd6h4c4 69 24 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 69 25 , , , work_j7kpdr5srze47kmsl2scd6h4c4 69 26 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 69 27 . . . work_j7kpdr5srze47kmsl2scd6h4c4 70 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 70 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 70 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 70 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 71 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 2 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 71 3 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 71 4 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 71 5 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 71 6 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 71 7 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 71 8 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 71 9 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 10 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 11 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 12 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 71 13 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 71 14 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 71 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 71 16 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 71 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 71 18 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 71 19 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 71 20 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 71 21 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 22 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 23 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 24 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 25 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 26 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 27 - - : work_j7kpdr5srze47kmsl2scd6h4c4 71 28 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 71 29 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 71 30 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 31 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 71 32 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 33 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 34 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 71 35 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 71 36 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 71 37 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 38 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 39 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 40 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 41 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 42 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 43 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 71 44 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 71 45 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 46 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 71 47 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 48 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 49 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 50 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 51 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 52 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 71 54 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 55 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 56 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 57 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 58 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 71 59 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 71 60 : : : work_j7kpdr5srze47kmsl2scd6h4c4 71 61 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 62 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 63 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 64 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 71 65 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 66 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 67 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 68 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 69 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 71 70 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 71 71 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 71 72 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 73 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 74 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 75 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 76 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 71 77 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 78 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 71 79 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 80 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 81 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 82 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 83 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 84 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 71 85 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 71 86 5 5 CD work_j7kpdr5srze47kmsl2scd6h4c4 71 87 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 71 88 , , , work_j7kpdr5srze47kmsl2scd6h4c4 71 89 we -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 71 90 recapitulated recapitulate VBD work_j7kpdr5srze47kmsl2scd6h4c4 71 91 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 71 92 vitro vitro FW work_j7kpdr5srze47kmsl2scd6h4c4 71 93 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 71 94 molecular molecular JJ work_j7kpdr5srze47kmsl2scd6h4c4 71 95 cascade cascade NN work_j7kpdr5srze47kmsl2scd6h4c4 71 96 involved involve VBN work_j7kpdr5srze47kmsl2scd6h4c4 71 97 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 71 98 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 71 99 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 71 100 steps step NNS work_j7kpdr5srze47kmsl2scd6h4c4 71 101 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 71 102 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 71 103 determination determination NN work_j7kpdr5srze47kmsl2scd6h4c4 71 104 . . . work_j7kpdr5srze47kmsl2scd6h4c4 72 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 72 2 that that DT work_j7kpdr5srze47kmsl2scd6h4c4 72 3 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 72 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 72 5 we -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 72 6 used use VBD work_j7kpdr5srze47kmsl2scd6h4c4 72 7 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 72 8 forced force VBN work_j7kpdr5srze47kmsl2scd6h4c4 72 9 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 72 10 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 72 11 wild wild JJ work_j7kpdr5srze47kmsl2scd6h4c4 72 12 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 72 13 type type NN work_j7kpdr5srze47kmsl2scd6h4c4 72 14 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 72 15 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 72 16 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 72 17 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 72 18 test test VB work_j7kpdr5srze47kmsl2scd6h4c4 72 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 72 20 functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 72 21 relevance relevance NN work_j7kpdr5srze47kmsl2scd6h4c4 72 22 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 72 23 mutated mutate VBN work_j7kpdr5srze47kmsl2scd6h4c4 72 24 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 72 25 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 72 26 identified identify VBN work_j7kpdr5srze47kmsl2scd6h4c4 72 27 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 72 28 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 72 29 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 72 30 . . . work_j7kpdr5srze47kmsl2scd6h4c4 73 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 73 2 showed show VBD work_j7kpdr5srze47kmsl2scd6h4c4 73 3 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 73 4 significant significant JJ work_j7kpdr5srze47kmsl2scd6h4c4 73 5 decrease decrease NN work_j7kpdr5srze47kmsl2scd6h4c4 73 6 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 73 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 73 8 number number NN work_j7kpdr5srze47kmsl2scd6h4c4 73 9 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 73 10 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 73 11 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 73 12 generated generate VBN work_j7kpdr5srze47kmsl2scd6h4c4 73 13 after after IN work_j7kpdr5srze47kmsl2scd6h4c4 73 14 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 73 15 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 73 16 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 73 17 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 73 18 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 73 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 74 1 However however RB work_j7kpdr5srze47kmsl2scd6h4c4 74 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 74 3 this this DT work_j7kpdr5srze47kmsl2scd6h4c4 74 4 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 74 5 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 74 6 limited limited JJ work_j7kpdr5srze47kmsl2scd6h4c4 74 7 effect effect NN work_j7kpdr5srze47kmsl2scd6h4c4 74 8 considering consider VBG work_j7kpdr5srze47kmsl2scd6h4c4 74 9 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 74 10 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 74 11 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 74 12 heterozygotes heterozygote NNS work_j7kpdr5srze47kmsl2scd6h4c4 74 13 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 74 14 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 74 15 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 74 16 mutated mutate VBN work_j7kpdr5srze47kmsl2scd6h4c4 74 17 allele allele NNP work_j7kpdr5srze47kmsl2scd6h4c4 74 18 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 74 19 opposed oppose VBN work_j7kpdr5srze47kmsl2scd6h4c4 74 20 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 74 21 our -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 74 22 experimental experimental JJ work_j7kpdr5srze47kmsl2scd6h4c4 74 23 model model NN work_j7kpdr5srze47kmsl2scd6h4c4 74 24 . . . work_j7kpdr5srze47kmsl2scd6h4c4 75 1 Nevertheless nevertheless RB work_j7kpdr5srze47kmsl2scd6h4c4 75 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 75 3 subtle subtle JJ work_j7kpdr5srze47kmsl2scd6h4c4 75 4 consequences consequence NNS work_j7kpdr5srze47kmsl2scd6h4c4 75 5 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 75 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 75 7 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 75 8 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 75 9 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 75 10 could could MD work_j7kpdr5srze47kmsl2scd6h4c4 75 11 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 75 12 expected expect VBN work_j7kpdr5srze47kmsl2scd6h4c4 75 13 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 75 14 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 75 15 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 75 16 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 75 17 lying lie VBG work_j7kpdr5srze47kmsl2scd6h4c4 75 18 outside outside RB work_j7kpdr5srze47kmsl2scd6h4c4 75 19 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 75 20 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 75 21 bHLH bhlh NN work_j7kpdr5srze47kmsl2scd6h4c4 75 22 domain domain NN work_j7kpdr5srze47kmsl2scd6h4c4 75 23 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 75 24 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 75 25 protein protein NN work_j7kpdr5srze47kmsl2scd6h4c4 75 26 . . . work_j7kpdr5srze47kmsl2scd6h4c4 76 1 Moreover moreover RB work_j7kpdr5srze47kmsl2scd6h4c4 76 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 76 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 76 4 HASH-1 hash-1 NN work_j7kpdr5srze47kmsl2scd6h4c4 76 5 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 76 6 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 76 7 located locate VBN work_j7kpdr5srze47kmsl2scd6h4c4 76 8 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 76 9 highly highly RB work_j7kpdr5srze47kmsl2scd6h4c4 76 10 conserved conserve VBN work_j7kpdr5srze47kmsl2scd6h4c4 76 11 regions region NNS work_j7kpdr5srze47kmsl2scd6h4c4 76 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 76 13 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 76 14 protein protein NN work_j7kpdr5srze47kmsl2scd6h4c4 76 15 , , , work_j7kpdr5srze47kmsl2scd6h4c4 76 16 although although IN work_j7kpdr5srze47kmsl2scd6h4c4 76 17 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 76 18 involved involve VBN work_j7kpdr5srze47kmsl2scd6h4c4 76 19 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 76 20 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 76 21 basic basic JJ work_j7kpdr5srze47kmsl2scd6h4c4 76 22 helix helix NN work_j7kpdr5srze47kmsl2scd6h4c4 76 23 – – : work_j7kpdr5srze47kmsl2scd6h4c4 76 24 loop loop NN work_j7kpdr5srze47kmsl2scd6h4c4 76 25 – – : work_j7kpdr5srze47kmsl2scd6h4c4 76 26 helix helix NN work_j7kpdr5srze47kmsl2scd6h4c4 76 27 consensus consensus NN work_j7kpdr5srze47kmsl2scd6h4c4 76 28 motives motive NNS work_j7kpdr5srze47kmsl2scd6h4c4 76 29 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 76 30 13 13 CD work_j7kpdr5srze47kmsl2scd6h4c4 76 31 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 76 32 . . . work_j7kpdr5srze47kmsl2scd6h4c4 77 1 Together together RB work_j7kpdr5srze47kmsl2scd6h4c4 77 2 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 77 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 77 4 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 77 5 pattern pattern NN work_j7kpdr5srze47kmsl2scd6h4c4 77 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 77 7 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 77 8 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 77 9 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 77 10 developing develop VBG work_j7kpdr5srze47kmsl2scd6h4c4 77 11 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 77 12 embryo embryo NN work_j7kpdr5srze47kmsl2scd6h4c4 77 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 77 14 these these DT work_j7kpdr5srze47kmsl2scd6h4c4 77 15 results result NNS work_j7kpdr5srze47kmsl2scd6h4c4 77 16 cope cope VBP work_j7kpdr5srze47kmsl2scd6h4c4 77 17 well well RB work_j7kpdr5srze47kmsl2scd6h4c4 77 18 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 77 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 77 20 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 77 21 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 77 22 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 77 23 Mash-1 Mash-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 77 24 þ/ þ/ NNP work_j7kpdr5srze47kmsl2scd6h4c4 77 25 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 77 26 mice mouse NNS work_j7kpdr5srze47kmsl2scd6h4c4 77 27 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 77 28 10 10 CD work_j7kpdr5srze47kmsl2scd6h4c4 77 29 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 77 30 . . . work_j7kpdr5srze47kmsl2scd6h4c4 78 1 These these DT work_j7kpdr5srze47kmsl2scd6h4c4 78 2 data datum NNS work_j7kpdr5srze47kmsl2scd6h4c4 78 3 also also RB work_j7kpdr5srze47kmsl2scd6h4c4 78 4 suggest suggest VBP work_j7kpdr5srze47kmsl2scd6h4c4 78 5 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 78 6 variant variant JJ work_j7kpdr5srze47kmsl2scd6h4c4 78 7 HASH-1 HASH-1 NNS work_j7kpdr5srze47kmsl2scd6h4c4 78 8 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 78 9 may may MD work_j7kpdr5srze47kmsl2scd6h4c4 78 10 contribute contribute VB work_j7kpdr5srze47kmsl2scd6h4c4 78 11 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 78 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 78 13 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 78 14 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 78 15 . . . work_j7kpdr5srze47kmsl2scd6h4c4 79 1 However however RB work_j7kpdr5srze47kmsl2scd6h4c4 79 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 79 3 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 79 4 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 79 5 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 79 6 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 79 7 neither neither RB work_j7kpdr5srze47kmsl2scd6h4c4 79 8 necessary necessary JJ work_j7kpdr5srze47kmsl2scd6h4c4 79 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 79 10 most most JJS work_j7kpdr5srze47kmsl2scd6h4c4 79 11 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 79 12 do do VBP work_j7kpdr5srze47kmsl2scd6h4c4 79 13 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 79 14 have have VB work_j7kpdr5srze47kmsl2scd6h4c4 79 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 79 16 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 79 17 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 79 18 variant variant NN work_j7kpdr5srze47kmsl2scd6h4c4 79 19 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 79 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 79 21 nor nor CC work_j7kpdr5srze47kmsl2scd6h4c4 79 22 sufficient sufficient JJ work_j7kpdr5srze47kmsl2scd6h4c4 79 23 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 79 24 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 79 25 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 79 26 occur occur VB work_j7kpdr5srze47kmsl2scd6h4c4 79 27 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 79 28 carriers carrier NNS work_j7kpdr5srze47kmsl2scd6h4c4 79 29 have have VBP work_j7kpdr5srze47kmsl2scd6h4c4 79 30 no no DT work_j7kpdr5srze47kmsl2scd6h4c4 79 31 phenotypic phenotypic JJ work_j7kpdr5srze47kmsl2scd6h4c4 79 32 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 79 33 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 79 34 . . . work_j7kpdr5srze47kmsl2scd6h4c4 80 1 This this DT work_j7kpdr5srze47kmsl2scd6h4c4 80 2 observation observation NN work_j7kpdr5srze47kmsl2scd6h4c4 80 3 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 80 4 reminiscent reminiscent JJ work_j7kpdr5srze47kmsl2scd6h4c4 80 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 80 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 80 7 findings finding NNS work_j7kpdr5srze47kmsl2scd6h4c4 80 8 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 80 9 isolated isolated JJ work_j7kpdr5srze47kmsl2scd6h4c4 80 10 Hirschsprung Hirschsprung NNP work_j7kpdr5srze47kmsl2scd6h4c4 80 11 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 80 12 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 80 13 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 80 14 Mennonite Mennonite NNP work_j7kpdr5srze47kmsl2scd6h4c4 80 15 population population NN work_j7kpdr5srze47kmsl2scd6h4c4 80 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 80 17 where where WRB work_j7kpdr5srze47kmsl2scd6h4c4 80 18 endothelin endothelin NNP work_j7kpdr5srze47kmsl2scd6h4c4 80 19 B B NNP work_j7kpdr5srze47kmsl2scd6h4c4 80 20 receptor receptor NN work_j7kpdr5srze47kmsl2scd6h4c4 80 21 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 80 22 EDNRB EDNRB NNP work_j7kpdr5srze47kmsl2scd6h4c4 80 23 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 80 24 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 80 25 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 80 26 neither neither RB work_j7kpdr5srze47kmsl2scd6h4c4 80 27 necessary necessary JJ work_j7kpdr5srze47kmsl2scd6h4c4 80 28 nor nor CC work_j7kpdr5srze47kmsl2scd6h4c4 80 29 sufficient sufficient JJ work_j7kpdr5srze47kmsl2scd6h4c4 80 30 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 80 31 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 80 32 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 80 33 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 80 34 occur occur VB work_j7kpdr5srze47kmsl2scd6h4c4 80 35 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 80 36 act act VB work_j7kpdr5srze47kmsl2scd6h4c4 80 37 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 80 38 conjunction conjunction NN work_j7kpdr5srze47kmsl2scd6h4c4 80 39 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 80 40 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 80 41 yet yet RB work_j7kpdr5srze47kmsl2scd6h4c4 80 42 unknown unknown JJ work_j7kpdr5srze47kmsl2scd6h4c4 80 43 hypomorphic hypomorphic JJ work_j7kpdr5srze47kmsl2scd6h4c4 80 44 RET ret NN work_j7kpdr5srze47kmsl2scd6h4c4 80 45 allele allele NNP work_j7kpdr5srze47kmsl2scd6h4c4 80 46 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 80 47 14 14 CD work_j7kpdr5srze47kmsl2scd6h4c4 80 48 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 80 49 . . . work_j7kpdr5srze47kmsl2scd6h4c4 81 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 81 2 question question NN work_j7kpdr5srze47kmsl2scd6h4c4 81 3 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 81 4 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 81 5 whether whether IN work_j7kpdr5srze47kmsl2scd6h4c4 81 6 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 81 7 acts act VBZ work_j7kpdr5srze47kmsl2scd6h4c4 81 8 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 81 9 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 81 10 modifier modifier NN work_j7kpdr5srze47kmsl2scd6h4c4 81 11 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 81 12 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 81 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 81 14 and/or and/or CC work_j7kpdr5srze47kmsl2scd6h4c4 81 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 81 16 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 81 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 81 18 causing cause VBG work_j7kpdr5srze47kmsl2scd6h4c4 81 19 autosomal autosomal JJ work_j7kpdr5srze47kmsl2scd6h4c4 81 20 dominant dominant JJ work_j7kpdr5srze47kmsl2scd6h4c4 81 21 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 81 22 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 81 23 incomplete incomplete JJ work_j7kpdr5srze47kmsl2scd6h4c4 81 24 penetrance penetrance NN work_j7kpdr5srze47kmsl2scd6h4c4 81 25 remains remain VBZ work_j7kpdr5srze47kmsl2scd6h4c4 81 26 unresolved unresolved JJ work_j7kpdr5srze47kmsl2scd6h4c4 81 27 . . . work_j7kpdr5srze47kmsl2scd6h4c4 82 1 Figure figure NN work_j7kpdr5srze47kmsl2scd6h4c4 82 2 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 82 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 83 1 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 83 2 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 83 3 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 83 4 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 83 5 phylogenetic phylogenetic JJ work_j7kpdr5srze47kmsl2scd6h4c4 83 6 analysis analysis NN work_j7kpdr5srze47kmsl2scd6h4c4 83 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 83 8 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 83 9 proteins protein NNS work_j7kpdr5srze47kmsl2scd6h4c4 83 10 . . . work_j7kpdr5srze47kmsl2scd6h4c4 84 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 84 2 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 84 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 84 4 HASH-1 hash-1 JJ work_j7kpdr5srze47kmsl2scd6h4c4 84 5 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 84 6 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 84 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 85 1 SSCP SSCP NNS work_j7kpdr5srze47kmsl2scd6h4c4 85 2 results result NNS work_j7kpdr5srze47kmsl2scd6h4c4 85 3 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 85 4 mutated mutated JJ work_j7kpdr5srze47kmsl2scd6h4c4 85 5 sequences sequence NNS work_j7kpdr5srze47kmsl2scd6h4c4 85 6 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 85 7 illustrated illustrate VBN work_j7kpdr5srze47kmsl2scd6h4c4 85 8 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 85 9 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 85 10 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 85 11 individuals individual NNS work_j7kpdr5srze47kmsl2scd6h4c4 85 12 whose whose WP$ work_j7kpdr5srze47kmsl2scd6h4c4 85 13 pedigrees pedigree NNS work_j7kpdr5srze47kmsl2scd6h4c4 85 14 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 85 15 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 85 16 directly directly RB work_j7kpdr5srze47kmsl2scd6h4c4 85 17 above above RB work_j7kpdr5srze47kmsl2scd6h4c4 85 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 86 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 86 2 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 86 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 86 4 Clustal Clustal NNP work_j7kpdr5srze47kmsl2scd6h4c4 86 5 W W NNP work_j7kpdr5srze47kmsl2scd6h4c4 86 6 alignment alignment NN work_j7kpdr5srze47kmsl2scd6h4c4 86 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 86 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 86 9 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 86 10 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 86 11 protein protein NN work_j7kpdr5srze47kmsl2scd6h4c4 86 12 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 86 13 its -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 86 14 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 86 15 , , , work_j7kpdr5srze47kmsl2scd6h4c4 86 16 Drosophila Drosophila NNP work_j7kpdr5srze47kmsl2scd6h4c4 86 17 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 86 18 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 86 19 elegans elegan NNS work_j7kpdr5srze47kmsl2scd6h4c4 86 20 orthologs ortholog VBZ work_j7kpdr5srze47kmsl2scd6h4c4 86 21 . . . work_j7kpdr5srze47kmsl2scd6h4c4 87 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 87 2 residues residue NNS work_j7kpdr5srze47kmsl2scd6h4c4 87 3 mutated mutate VBD work_j7kpdr5srze47kmsl2scd6h4c4 87 4 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 87 5 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 87 6 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 87 7 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 87 8 indicated indicate VBN work_j7kpdr5srze47kmsl2scd6h4c4 87 9 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 87 10 arrows arrow NNS work_j7kpdr5srze47kmsl2scd6h4c4 87 11 . . . work_j7kpdr5srze47kmsl2scd6h4c4 88 1 Note note VB work_j7kpdr5srze47kmsl2scd6h4c4 88 2 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 88 3 conservation conservation NN work_j7kpdr5srze47kmsl2scd6h4c4 88 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 88 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 88 6 basic basic JJ work_j7kpdr5srze47kmsl2scd6h4c4 88 7 , , , work_j7kpdr5srze47kmsl2scd6h4c4 88 8 helix helix JJ work_j7kpdr5srze47kmsl2scd6h4c4 88 9 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 88 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 88 11 loop loop NN work_j7kpdr5srze47kmsl2scd6h4c4 88 12 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 88 13 helix2 helix2 NN work_j7kpdr5srze47kmsl2scd6h4c4 88 14 amino amino NN work_j7kpdr5srze47kmsl2scd6h4c4 88 15 acid acid NN work_j7kpdr5srze47kmsl2scd6h4c4 88 16 domains domain NNS work_j7kpdr5srze47kmsl2scd6h4c4 88 17 between between IN work_j7kpdr5srze47kmsl2scd6h4c4 88 18 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 88 19 four four CD work_j7kpdr5srze47kmsl2scd6h4c4 88 20 species specie NNS work_j7kpdr5srze47kmsl2scd6h4c4 88 21 studied study VBN work_j7kpdr5srze47kmsl2scd6h4c4 88 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 89 1 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 89 2 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 89 3 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 89 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 89 5 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 89 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 89 7 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 89 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 90 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 90 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 90 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 90 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 91 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 2 3175 3175 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 3 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 91 4 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 91 5 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 91 6 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 91 7 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 91 8 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 91 9 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 91 10 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 11 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 12 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 13 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 91 14 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 91 15 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 91 16 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 91 17 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 91 18 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 91 19 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 91 20 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 91 21 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 91 22 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 23 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 24 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 25 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 26 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 27 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 28 - - : work_j7kpdr5srze47kmsl2scd6h4c4 91 29 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 91 30 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 91 31 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 32 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 91 33 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 34 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 35 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 91 36 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 91 37 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 91 38 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 39 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 40 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 41 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 42 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 43 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 44 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 91 45 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 91 46 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 47 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 91 48 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 49 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 50 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 51 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 52 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 53 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 54 , , , work_j7kpdr5srze47kmsl2scd6h4c4 91 55 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 56 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 57 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 58 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 91 59 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 91 60 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 91 61 : : : work_j7kpdr5srze47kmsl2scd6h4c4 91 62 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 63 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 64 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 65 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 91 66 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 67 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 68 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 69 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 70 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 91 71 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 91 72 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 91 73 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 74 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 75 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 76 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 77 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 91 78 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 79 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 91 80 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 81 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 82 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 83 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 84 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 85 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 86 Polyalanine Polyalanine NNP work_j7kpdr5srze47kmsl2scd6h4c4 91 87 repeats repeat NNS work_j7kpdr5srze47kmsl2scd6h4c4 91 88 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 91 89 common common JJ work_j7kpdr5srze47kmsl2scd6h4c4 91 90 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 91 91 transcription transcription NN work_j7kpdr5srze47kmsl2scd6h4c4 91 92 factors factor NNS work_j7kpdr5srze47kmsl2scd6h4c4 91 93 but but CC work_j7kpdr5srze47kmsl2scd6h4c4 91 94 their -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 91 95 normal normal JJ work_j7kpdr5srze47kmsl2scd6h4c4 91 96 function function NN work_j7kpdr5srze47kmsl2scd6h4c4 91 97 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 91 98 largely largely RB work_j7kpdr5srze47kmsl2scd6h4c4 91 99 unknown unknown JJ work_j7kpdr5srze47kmsl2scd6h4c4 91 100 . . . work_j7kpdr5srze47kmsl2scd6h4c4 92 1 Expansions expansion NNS work_j7kpdr5srze47kmsl2scd6h4c4 92 2 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 92 3 polyalanine polyalanine NN work_j7kpdr5srze47kmsl2scd6h4c4 92 4 tracts tract NNS work_j7kpdr5srze47kmsl2scd6h4c4 92 5 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 92 6 transcription transcription NN work_j7kpdr5srze47kmsl2scd6h4c4 92 7 factors factor NNS work_j7kpdr5srze47kmsl2scd6h4c4 92 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 92 9 including include VBG work_j7kpdr5srze47kmsl2scd6h4c4 92 10 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 92 11 novo novo NNP work_j7kpdr5srze47kmsl2scd6h4c4 92 12 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 92 13 polyalanine polyalanine NN work_j7kpdr5srze47kmsl2scd6h4c4 92 14 expansions expansion NNS work_j7kpdr5srze47kmsl2scd6h4c4 92 15 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 92 16 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 92 17 , , , work_j7kpdr5srze47kmsl2scd6h4c4 92 18 have have VBP work_j7kpdr5srze47kmsl2scd6h4c4 92 19 been be VBN work_j7kpdr5srze47kmsl2scd6h4c4 92 20 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 92 21 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 92 22 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 92 23 responsible responsible JJ work_j7kpdr5srze47kmsl2scd6h4c4 92 24 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 92 25 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 92 26 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 92 27 several several JJ work_j7kpdr5srze47kmsl2scd6h4c4 92 28 malformation malformation NN work_j7kpdr5srze47kmsl2scd6h4c4 92 29 syndromes syndrome VBZ work_j7kpdr5srze47kmsl2scd6h4c4 92 30 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 92 31 humans human NNS work_j7kpdr5srze47kmsl2scd6h4c4 92 32 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 92 33 15,16 15,16 CD work_j7kpdr5srze47kmsl2scd6h4c4 92 34 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 92 35 , , , work_j7kpdr5srze47kmsl2scd6h4c4 92 36 whereas whereas IN work_j7kpdr5srze47kmsl2scd6h4c4 92 37 contractions contraction NNS work_j7kpdr5srze47kmsl2scd6h4c4 92 38 have have VBP work_j7kpdr5srze47kmsl2scd6h4c4 92 39 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 92 40 been be VBN work_j7kpdr5srze47kmsl2scd6h4c4 92 41 reported report VBN work_j7kpdr5srze47kmsl2scd6h4c4 92 42 thus thus RB work_j7kpdr5srze47kmsl2scd6h4c4 92 43 far far RB work_j7kpdr5srze47kmsl2scd6h4c4 92 44 . . . work_j7kpdr5srze47kmsl2scd6h4c4 93 1 Polyalanine polyalanine JJ work_j7kpdr5srze47kmsl2scd6h4c4 93 2 contractions contraction NNS work_j7kpdr5srze47kmsl2scd6h4c4 93 3 may may MD work_j7kpdr5srze47kmsl2scd6h4c4 93 4 therefore therefore RB work_j7kpdr5srze47kmsl2scd6h4c4 93 5 act act VB work_j7kpdr5srze47kmsl2scd6h4c4 93 6 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 93 7 hypomorphic hypomorphic JJ work_j7kpdr5srze47kmsl2scd6h4c4 93 8 alleles allele NNS work_j7kpdr5srze47kmsl2scd6h4c4 93 9 . . . work_j7kpdr5srze47kmsl2scd6h4c4 94 1 As as IN work_j7kpdr5srze47kmsl2scd6h4c4 94 2 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 94 3 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 94 4 phenotypes phenotype NNS work_j7kpdr5srze47kmsl2scd6h4c4 94 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 94 6 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 94 7 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 94 8 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 94 9 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 94 10 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 94 11 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 94 12 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 94 13 undistinguishable undistinguishable JJ work_j7kpdr5srze47kmsl2scd6h4c4 94 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 94 15 our -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 94 16 data datum NNS work_j7kpdr5srze47kmsl2scd6h4c4 94 17 suggest suggest VBP work_j7kpdr5srze47kmsl2scd6h4c4 94 18 that that IN work_j7kpdr5srze47kmsl2scd6h4c4 94 19 any any DT work_j7kpdr5srze47kmsl2scd6h4c4 94 20 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 94 21 affecting affect VBG work_j7kpdr5srze47kmsl2scd6h4c4 94 22 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 94 23 HASH-1–PHOX HASH-1–PHOX NNP work_j7kpdr5srze47kmsl2scd6h4c4 94 24 developmental developmental JJ work_j7kpdr5srze47kmsl2scd6h4c4 94 25 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 94 26 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 94 27 likely likely JJ work_j7kpdr5srze47kmsl2scd6h4c4 94 28 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 94 29 impair impair VB work_j7kpdr5srze47kmsl2scd6h4c4 94 30 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 94 31 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 94 32 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 94 33 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 94 34 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 94 35 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 94 36 Figure Figure NNP work_j7kpdr5srze47kmsl2scd6h4c4 94 37 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 94 38 . . . work_j7kpdr5srze47kmsl2scd6h4c4 95 1 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 95 2 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 95 3 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 95 4 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 95 5 developing develop VBG work_j7kpdr5srze47kmsl2scd6h4c4 95 6 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 95 7 embryos embryo NNS work_j7kpdr5srze47kmsl2scd6h4c4 95 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 96 1 Slides slide NNS work_j7kpdr5srze47kmsl2scd6h4c4 96 2 stained stain VBN work_j7kpdr5srze47kmsl2scd6h4c4 96 3 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 96 4 hematoxylin hematoxylin NN work_j7kpdr5srze47kmsl2scd6h4c4 96 5 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 96 6 eosin eosin NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 7 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 8 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 96 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 10 C c NN work_j7kpdr5srze47kmsl2scd6h4c4 96 11 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 12 E e NN work_j7kpdr5srze47kmsl2scd6h4c4 96 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 14 G g NN work_j7kpdr5srze47kmsl2scd6h4c4 96 15 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 16 I -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 96 17 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 18 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 96 19 dark dark JJ work_j7kpdr5srze47kmsl2scd6h4c4 96 20 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 96 21 field field NN work_j7kpdr5srze47kmsl2scd6h4c4 96 22 illumination illumination NN work_j7kpdr5srze47kmsl2scd6h4c4 96 23 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 96 24 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 96 25 hybri- hybri- NN work_j7kpdr5srze47kmsl2scd6h4c4 96 26 dized dize VBN work_j7kpdr5srze47kmsl2scd6h4c4 96 27 adjacent adjacent JJ work_j7kpdr5srze47kmsl2scd6h4c4 96 28 sections section NNS work_j7kpdr5srze47kmsl2scd6h4c4 96 29 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 30 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 96 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 32 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 34 F f NN work_j7kpdr5srze47kmsl2scd6h4c4 96 35 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 36 H H NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 37 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 38 J J NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 39 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 40 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 96 41 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 96 42 32 32 CD work_j7kpdr5srze47kmsl2scd6h4c4 96 43 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 44 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 45 14 14 CD work_j7kpdr5srze47kmsl2scd6h4c4 96 46 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 47 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 96 48 – – : work_j7kpdr5srze47kmsl2scd6h4c4 96 49 D d NN work_j7kpdr5srze47kmsl2scd6h4c4 96 50 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 51 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 52 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 96 53 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 96 54 44 44 CD work_j7kpdr5srze47kmsl2scd6h4c4 96 55 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 56 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 57 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 96 58 , , , work_j7kpdr5srze47kmsl2scd6h4c4 96 59 E e NN work_j7kpdr5srze47kmsl2scd6h4c4 96 60 – – : work_j7kpdr5srze47kmsl2scd6h4c4 96 61 J J NNP work_j7kpdr5srze47kmsl2scd6h4c4 96 62 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 96 63 . . . work_j7kpdr5srze47kmsl2scd6h4c4 97 1 Parasagittal parasagittal JJ work_j7kpdr5srze47kmsl2scd6h4c4 97 2 sections section NNS work_j7kpdr5srze47kmsl2scd6h4c4 97 3 showing show VBG work_j7kpdr5srze47kmsl2scd6h4c4 97 4 weak weak JJ work_j7kpdr5srze47kmsl2scd6h4c4 97 5 HASH-1 hash-1 NN work_j7kpdr5srze47kmsl2scd6h4c4 97 6 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 97 7 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 97 8 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 97 9 stage stage NN work_j7kpdr5srze47kmsl2scd6h4c4 97 10 14 14 CD work_j7kpdr5srze47kmsl2scd6h4c4 97 11 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 97 12 strong strong JJ work_j7kpdr5srze47kmsl2scd6h4c4 97 13 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 97 14 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 97 15 this this DT work_j7kpdr5srze47kmsl2scd6h4c4 97 16 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 97 17 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 97 18 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 97 19 stage stage NN work_j7kpdr5srze47kmsl2scd6h4c4 97 20 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 97 21 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 97 22 mesencephalon mesencephalon NN work_j7kpdr5srze47kmsl2scd6h4c4 97 23 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 24 mes mes NNP work_j7kpdr5srze47kmsl2scd6h4c4 97 25 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 97 27 rhombencephalon rhombencephalon NNP work_j7kpdr5srze47kmsl2scd6h4c4 97 28 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 29 rh rh NNP work_j7kpdr5srze47kmsl2scd6h4c4 97 30 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 97 32 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 97 33 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 97 34 dorsal dorsal NN work_j7kpdr5srze47kmsl2scd6h4c4 97 35 area area NN work_j7kpdr5srze47kmsl2scd6h4c4 97 36 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 97 37 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 97 38 spinal spinal JJ work_j7kpdr5srze47kmsl2scd6h4c4 97 39 cord cord NN work_j7kpdr5srze47kmsl2scd6h4c4 97 40 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 41 sc sc NNP work_j7kpdr5srze47kmsl2scd6h4c4 97 42 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 43 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 44 arrowheads arrowhead NNS work_j7kpdr5srze47kmsl2scd6h4c4 97 45 , , , work_j7kpdr5srze47kmsl2scd6h4c4 97 46 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 97 47 , , , work_j7kpdr5srze47kmsl2scd6h4c4 97 48 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 97 49 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 97 50 E e NN work_j7kpdr5srze47kmsl2scd6h4c4 97 51 – – : work_j7kpdr5srze47kmsl2scd6h4c4 97 52 H h NN work_j7kpdr5srze47kmsl2scd6h4c4 97 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 97 54 respectively respectively RB work_j7kpdr5srze47kmsl2scd6h4c4 97 55 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 97 56 . . . work_j7kpdr5srze47kmsl2scd6h4c4 98 1 From from IN work_j7kpdr5srze47kmsl2scd6h4c4 98 2 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 98 3 stage stage NN work_j7kpdr5srze47kmsl2scd6h4c4 98 4 14 14 CD work_j7kpdr5srze47kmsl2scd6h4c4 98 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 98 6 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 98 7 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 98 8 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 98 9 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 98 10 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 98 11 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 98 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 98 13 side side NN work_j7kpdr5srze47kmsl2scd6h4c4 98 14 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 98 15 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 98 16 dorsal dorsal NN work_j7kpdr5srze47kmsl2scd6h4c4 98 17 aorta aorta NNP work_j7kpdr5srze47kmsl2scd6h4c4 98 18 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 98 19 arrow arrow NNP work_j7kpdr5srze47kmsl2scd6h4c4 98 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 98 21 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 98 22 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 98 23 . . . work_j7kpdr5srze47kmsl2scd6h4c4 99 1 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 2 expres- expres- VBZ work_j7kpdr5srze47kmsl2scd6h4c4 99 3 sion sion NN work_j7kpdr5srze47kmsl2scd6h4c4 99 4 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 99 5 also also RB work_j7kpdr5srze47kmsl2scd6h4c4 99 6 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 99 7 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 99 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 99 9 intestine intestine NN work_j7kpdr5srze47kmsl2scd6h4c4 99 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 11 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 99 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 99 13 foregut foregut NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 14 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 99 15 arrow arrow NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 17 F F NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 18 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 99 19 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 99 20 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 99 21 hindgut hindgut NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 22 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 99 23 arrow arrow NN work_j7kpdr5srze47kmsl2scd6h4c4 99 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 25 H H NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 26 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 99 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 28 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 99 29 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 99 30 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 99 31 adrenal adrenal JJ work_j7kpdr5srze47kmsl2scd6h4c4 99 32 medulla medulla NN work_j7kpdr5srze47kmsl2scd6h4c4 99 33 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 99 34 arrow arrow NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 35 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 36 J J NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 37 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 99 38 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 99 39 Carnegie Carnegie NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 40 stage stage NN work_j7kpdr5srze47kmsl2scd6h4c4 99 41 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 99 42 . . . work_j7kpdr5srze47kmsl2scd6h4c4 99 43 ad ad NN work_j7kpdr5srze47kmsl2scd6h4c4 99 44 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 45 Adrenal Adrenal NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 46 gland gland NN work_j7kpdr5srze47kmsl2scd6h4c4 99 47 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 48 ao ao NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 49 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 50 aorta aorta NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 51 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 52 go go VB work_j7kpdr5srze47kmsl2scd6h4c4 99 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 54 gonad gonad NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 55 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 56 meta meta NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 57 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 58 metanephros metanephros NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 59 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 60 mes mes NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 61 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 62 mesencephalon mesencephalon NN work_j7kpdr5srze47kmsl2scd6h4c4 99 63 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 64 meso meso NN work_j7kpdr5srze47kmsl2scd6h4c4 99 65 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 66 mesonephros mesonephro NNS work_j7kpdr5srze47kmsl2scd6h4c4 99 67 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 68 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 69 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 70 esophagus esophagus NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 71 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 72 re re IN work_j7kpdr5srze47kmsl2scd6h4c4 99 73 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 74 rectum rectum NN work_j7kpdr5srze47kmsl2scd6h4c4 99 75 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 76 rh rh NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 77 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 78 rhombencephalon rhombencephalon NNP work_j7kpdr5srze47kmsl2scd6h4c4 99 79 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 99 80 sc sc JJ work_j7kpdr5srze47kmsl2scd6h4c4 99 81 , , , work_j7kpdr5srze47kmsl2scd6h4c4 99 82 spinal spinal JJ work_j7kpdr5srze47kmsl2scd6h4c4 99 83 cord cord NN work_j7kpdr5srze47kmsl2scd6h4c4 99 84 . . . work_j7kpdr5srze47kmsl2scd6h4c4 100 1 3176 3176 CD work_j7kpdr5srze47kmsl2scd6h4c4 100 2 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 100 3 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 100 4 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 100 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 100 6 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 100 7 , , , work_j7kpdr5srze47kmsl2scd6h4c4 100 8 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 100 9 . . . work_j7kpdr5srze47kmsl2scd6h4c4 101 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 101 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 101 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 101 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 102 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 2 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 102 3 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 102 4 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 102 5 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 102 6 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 102 7 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 102 8 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 102 9 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 10 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 11 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 12 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 102 13 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 102 14 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 102 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 102 16 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 102 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 102 18 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 102 19 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 102 20 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 102 21 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 22 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 23 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 24 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 25 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 26 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 27 - - : work_j7kpdr5srze47kmsl2scd6h4c4 102 28 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 102 29 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 102 30 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 31 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 102 32 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 33 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 34 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 102 35 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 102 36 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 102 37 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 38 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 39 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 40 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 41 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 42 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 43 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 102 44 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 102 45 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 46 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 102 47 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 48 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 49 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 50 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 51 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 52 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 102 54 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 55 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 56 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 57 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 58 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 102 59 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 102 60 : : : work_j7kpdr5srze47kmsl2scd6h4c4 102 61 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 62 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 63 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 64 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 102 65 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 66 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 67 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 68 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 69 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 102 70 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 102 71 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 102 72 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 73 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 74 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 75 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 76 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 102 77 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 78 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 102 79 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 80 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 81 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 82 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 83 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 84 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 85 Figure Figure NNP work_j7kpdr5srze47kmsl2scd6h4c4 102 86 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 102 87 . . . work_j7kpdr5srze47kmsl2scd6h4c4 103 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 103 2 vitro vitro FW work_j7kpdr5srze47kmsl2scd6h4c4 103 3 culture culture NN work_j7kpdr5srze47kmsl2scd6h4c4 103 4 model model NN work_j7kpdr5srze47kmsl2scd6h4c4 103 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 103 6 mouse mouse NNP work_j7kpdr5srze47kmsl2scd6h4c4 103 7 vagal vagal NNP work_j7kpdr5srze47kmsl2scd6h4c4 103 8 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 103 9 crest crest NNP work_j7kpdr5srze47kmsl2scd6h4c4 103 10 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 103 11 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 103 12 analyze analyze VB work_j7kpdr5srze47kmsl2scd6h4c4 103 13 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 103 14 HASH-1–PHOX2B HASH-1–PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 103 15 / / SYM work_j7kpdr5srze47kmsl2scd6h4c4 103 16 PHOX2A PHOX2A NNP work_j7kpdr5srze47kmsl2scd6h4c4 103 17 cascade cascade NN work_j7kpdr5srze47kmsl2scd6h4c4 103 18 controlling control VBG work_j7kpdr5srze47kmsl2scd6h4c4 103 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 104 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 104 2 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 104 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 104 4 Experimental experimental JJ work_j7kpdr5srze47kmsl2scd6h4c4 104 5 design design NN work_j7kpdr5srze47kmsl2scd6h4c4 104 6 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 104 7 NCSCs NCSCs NNPS work_j7kpdr5srze47kmsl2scd6h4c4 104 8 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 104 9 isolated isolate VBN work_j7kpdr5srze47kmsl2scd6h4c4 104 10 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 104 11 E9.5 E9.5 NNP work_j7kpdr5srze47kmsl2scd6h4c4 104 12 mouse mouse NNP work_j7kpdr5srze47kmsl2scd6h4c4 104 13 embryo embryo NNP work_j7kpdr5srze47kmsl2scd6h4c4 104 14 neural neural NNP work_j7kpdr5srze47kmsl2scd6h4c4 104 15 tubes tubes NNP work_j7kpdr5srze47kmsl2scd6h4c4 104 16 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 104 17 NT NT NNP work_j7kpdr5srze47kmsl2scd6h4c4 104 18 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 104 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 105 1 Ec Ec NNP work_j7kpdr5srze47kmsl2scd6h4c4 105 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 105 3 ectoderm ectoderm NN work_j7kpdr5srze47kmsl2scd6h4c4 105 4 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 105 5 Som Som NNP work_j7kpdr5srze47kmsl2scd6h4c4 105 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 105 7 somite somite JJ work_j7kpdr5srze47kmsl2scd6h4c4 105 8 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 105 9 End end NN work_j7kpdr5srze47kmsl2scd6h4c4 105 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 105 11 endoderm endoderm NN work_j7kpdr5srze47kmsl2scd6h4c4 105 12 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 105 13 NC NC NNP work_j7kpdr5srze47kmsl2scd6h4c4 105 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 105 15 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 105 16 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 105 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 106 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 106 2 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 106 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 106 4 Transcription transcription NN work_j7kpdr5srze47kmsl2scd6h4c4 106 5 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 106 6 factor factor NN work_j7kpdr5srze47kmsl2scd6h4c4 106 7 cascade cascade NN work_j7kpdr5srze47kmsl2scd6h4c4 106 8 controlling control VBG work_j7kpdr5srze47kmsl2scd6h4c4 106 9 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 106 10 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 106 11 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 106 12 tyrosine tyrosine NN work_j7kpdr5srze47kmsl2scd6h4c4 106 13 hydroxylase hydroxylase NN work_j7kpdr5srze47kmsl2scd6h4c4 106 14 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 106 15 TH th NN work_j7kpdr5srze47kmsl2scd6h4c4 106 16 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 106 17 lineage lineage NN work_j7kpdr5srze47kmsl2scd6h4c4 106 18 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 106 19 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 106 20 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 106 21 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 106 22 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 106 23 NCSCs NCSCs NNP work_j7kpdr5srze47kmsl2scd6h4c4 106 24 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 106 25 . . . work_j7kpdr5srze47kmsl2scd6h4c4 107 1 Cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 107 2 cultured cultured JJ work_j7kpdr5srze47kmsl2scd6h4c4 107 3 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 107 4 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 107 5 presence presence NN work_j7kpdr5srze47kmsl2scd6h4c4 107 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 107 7 diffusible diffusible JJ work_j7kpdr5srze47kmsl2scd6h4c4 107 8 embryonic embryonic JJ work_j7kpdr5srze47kmsl2scd6h4c4 107 9 mesodermic mesodermic JJ work_j7kpdr5srze47kmsl2scd6h4c4 107 10 factors factor NNS work_j7kpdr5srze47kmsl2scd6h4c4 107 11 retain retain VBP work_j7kpdr5srze47kmsl2scd6h4c4 107 12 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 107 13 capacity capacity NN work_j7kpdr5srze47kmsl2scd6h4c4 107 14 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 107 15 generate generate VB work_j7kpdr5srze47kmsl2scd6h4c4 107 16 catecholaminergic catecholaminergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 107 17 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 107 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 107 19 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 107 20 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 107 21 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 107 22 neurofilament neurofilament NN work_j7kpdr5srze47kmsl2scd6h4c4 107 23 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 107 24 NF160 NF160 NNP work_j7kpdr5srze47kmsl2scd6h4c4 107 25 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 107 26 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 107 27 TH th NN work_j7kpdr5srze47kmsl2scd6h4c4 107 28 production production NN work_j7kpdr5srze47kmsl2scd6h4c4 107 29 , , , work_j7kpdr5srze47kmsl2scd6h4c4 107 30 recapitulating recapitulate VBG work_j7kpdr5srze47kmsl2scd6h4c4 107 31 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 107 32 MASH1–PHOX2B mash1–phox2b NN work_j7kpdr5srze47kmsl2scd6h4c4 107 33 – – : work_j7kpdr5srze47kmsl2scd6h4c4 107 34 PHOX2A PHOX2A NNP work_j7kpdr5srze47kmsl2scd6h4c4 107 35 – – : work_j7kpdr5srze47kmsl2scd6h4c4 107 36 RET RET NNP work_j7kpdr5srze47kmsl2scd6h4c4 107 37 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 107 38 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 107 39 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 107 40 vivo vivo NNP work_j7kpdr5srze47kmsl2scd6h4c4 107 41 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 107 42 lower low JJR work_j7kpdr5srze47kmsl2scd6h4c4 107 43 arrow arrow NN work_j7kpdr5srze47kmsl2scd6h4c4 107 44 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 107 45 . . . work_j7kpdr5srze47kmsl2scd6h4c4 108 1 Conversely conversely RB work_j7kpdr5srze47kmsl2scd6h4c4 108 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 108 3 NCSCs NCSCs NNP work_j7kpdr5srze47kmsl2scd6h4c4 108 4 cultured culture VBN work_j7kpdr5srze47kmsl2scd6h4c4 108 5 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 108 6 medium medium NN work_j7kpdr5srze47kmsl2scd6h4c4 108 7 containing contain VBG work_j7kpdr5srze47kmsl2scd6h4c4 108 8 serum serum NN work_j7kpdr5srze47kmsl2scd6h4c4 108 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 108 10 FCS FCS NNP work_j7kpdr5srze47kmsl2scd6h4c4 108 11 medium medium NN work_j7kpdr5srze47kmsl2scd6h4c4 108 12 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 108 13 remain remain VBP work_j7kpdr5srze47kmsl2scd6h4c4 108 14 multipotent multipotent NN work_j7kpdr5srze47kmsl2scd6h4c4 108 15 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 108 16 retain retain VB work_j7kpdr5srze47kmsl2scd6h4c4 108 17 their -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 108 18 proliferative proliferative JJ work_j7kpdr5srze47kmsl2scd6h4c4 108 19 abilities ability NNS work_j7kpdr5srze47kmsl2scd6h4c4 108 20 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 108 21 upper upper JJ work_j7kpdr5srze47kmsl2scd6h4c4 108 22 arrow arrow NN work_j7kpdr5srze47kmsl2scd6h4c4 108 23 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 108 24 . . . work_j7kpdr5srze47kmsl2scd6h4c4 109 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 2 C C NNP work_j7kpdr5srze47kmsl2scd6h4c4 109 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 4 Sequential sequential JJ work_j7kpdr5srze47kmsl2scd6h4c4 109 5 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 109 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 109 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 109 8 Mash1–Phox2a Mash1–Phox2a NNP work_j7kpdr5srze47kmsl2scd6h4c4 109 9 – – : work_j7kpdr5srze47kmsl2scd6h4c4 109 10 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 109 11 – – : work_j7kpdr5srze47kmsl2scd6h4c4 109 12 TH th NN work_j7kpdr5srze47kmsl2scd6h4c4 109 13 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 109 14 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 109 15 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 16 studied study VBN work_j7kpdr5srze47kmsl2scd6h4c4 109 17 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 109 18 cultured cultured JJ work_j7kpdr5srze47kmsl2scd6h4c4 109 19 NCSCs NCSCs NNP work_j7kpdr5srze47kmsl2scd6h4c4 109 20 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 109 21 immunohistochemistry immunohistochemistry NN work_j7kpdr5srze47kmsl2scd6h4c4 109 22 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 23 first first RB work_j7kpdr5srze47kmsl2scd6h4c4 109 24 row row NN work_j7kpdr5srze47kmsl2scd6h4c4 109 25 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 27 peripherin peripherin NNP work_j7kpdr5srze47kmsl2scd6h4c4 109 28 staining stain VBG work_j7kpdr5srze47kmsl2scd6h4c4 109 29 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 30 Per per IN work_j7kpdr5srze47kmsl2scd6h4c4 109 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 32 second second JJ work_j7kpdr5srze47kmsl2scd6h4c4 109 33 row row NN work_j7kpdr5srze47kmsl2scd6h4c4 109 34 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 35 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 36 merged merge VBD work_j7kpdr5srze47kmsl2scd6h4c4 109 37 immunohistochemistry immunohistochemistry NN work_j7kpdr5srze47kmsl2scd6h4c4 109 38 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 109 39 peripherin peripherin VB work_j7kpdr5srze47kmsl2scd6h4c4 109 40 staining staining NN work_j7kpdr5srze47kmsl2scd6h4c4 109 41 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 42 merged merged JJ work_j7kpdr5srze47kmsl2scd6h4c4 109 43 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 44 third third JJ work_j7kpdr5srze47kmsl2scd6h4c4 109 45 row row NN work_j7kpdr5srze47kmsl2scd6h4c4 109 46 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 47 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 109 48 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 109 49 situ situ VBN work_j7kpdr5srze47kmsl2scd6h4c4 109 50 hybridization hybridization NN work_j7kpdr5srze47kmsl2scd6h4c4 109 51 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 52 phase phase NN work_j7kpdr5srze47kmsl2scd6h4c4 109 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 54 fourth fourth JJ work_j7kpdr5srze47kmsl2scd6h4c4 109 55 row row NN work_j7kpdr5srze47kmsl2scd6h4c4 109 56 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 57 , , , work_j7kpdr5srze47kmsl2scd6h4c4 109 58 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 109 59 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 109 60 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 109 61 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 109 62 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 109 63 5 5 CD work_j7kpdr5srze47kmsl2scd6h4c4 109 64 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 65 d1–d5 d1–d5 NN work_j7kpdr5srze47kmsl2scd6h4c4 109 66 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 109 67 . . . work_j7kpdr5srze47kmsl2scd6h4c4 110 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 110 2 Mash1 mash1 JJ work_j7kpdr5srze47kmsl2scd6h4c4 110 3 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 4 d1 d1 NN work_j7kpdr5srze47kmsl2scd6h4c4 110 5 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 110 7 Phox2a Phox2a NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 9 d2 d2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 10 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 11 , , , work_j7kpdr5srze47kmsl2scd6h4c4 110 12 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 13 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 14 d3 d3 NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 16 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 110 17 TH TH NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 18 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 19 d5 d5 NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 20 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 21 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 110 22 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 110 23 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 110 24 red red JJ work_j7kpdr5srze47kmsl2scd6h4c4 110 25 fluorescence fluorescence NN work_j7kpdr5srze47kmsl2scd6h4c4 110 26 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 110 27 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 110 28 peripherin peripherin NN work_j7kpdr5srze47kmsl2scd6h4c4 110 29 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 30 d1–d3 d1–d3 FW work_j7kpdr5srze47kmsl2scd6h4c4 110 31 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 32 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 110 33 neurofilament neurofilament NN work_j7kpdr5srze47kmsl2scd6h4c4 110 34 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 35 NF160 NF160 NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 36 , , , work_j7kpdr5srze47kmsl2scd6h4c4 110 37 NF NF NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 38 , , , work_j7kpdr5srze47kmsl2scd6h4c4 110 39 d5 d5 NNP work_j7kpdr5srze47kmsl2scd6h4c4 110 40 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 110 41 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 110 42 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 110 43 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 110 44 green green JJ work_j7kpdr5srze47kmsl2scd6h4c4 110 45 fluorescence fluorescence NN work_j7kpdr5srze47kmsl2scd6h4c4 110 46 . . . work_j7kpdr5srze47kmsl2scd6h4c4 111 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 111 2 D d NN work_j7kpdr5srze47kmsl2scd6h4c4 111 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 111 4 Temporal temporal JJ work_j7kpdr5srze47kmsl2scd6h4c4 111 5 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 111 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 111 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 111 8 Mash1–Phox2a Mash1–Phox2a NNP work_j7kpdr5srze47kmsl2scd6h4c4 111 9 – – : work_j7kpdr5srze47kmsl2scd6h4c4 111 10 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 111 11 – – : work_j7kpdr5srze47kmsl2scd6h4c4 111 12 TH th NN work_j7kpdr5srze47kmsl2scd6h4c4 111 13 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 111 14 pathway pathway NN work_j7kpdr5srze47kmsl2scd6h4c4 111 15 during during IN work_j7kpdr5srze47kmsl2scd6h4c4 111 16 NCSCs NCSCs NNP work_j7kpdr5srze47kmsl2scd6h4c4 111 17 culture culture NN work_j7kpdr5srze47kmsl2scd6h4c4 111 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 111 19 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 111 20 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 111 21 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 111 22 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 111 23 d0 d0 NN work_j7kpdr5srze47kmsl2scd6h4c4 111 24 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 111 25 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 111 26 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 111 27 6 6 CD work_j7kpdr5srze47kmsl2scd6h4c4 111 28 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 111 29 d6 d6 NN work_j7kpdr5srze47kmsl2scd6h4c4 111 30 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 111 31 . . . work_j7kpdr5srze47kmsl2scd6h4c4 112 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 112 2 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 112 3 timing timing NN work_j7kpdr5srze47kmsl2scd6h4c4 112 4 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 112 5 Mash1 Mash1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 112 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 112 7 Phox2a Phox2a NNP work_j7kpdr5srze47kmsl2scd6h4c4 112 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 112 9 Ret Ret NNP work_j7kpdr5srze47kmsl2scd6h4c4 112 10 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 112 11 TH TH NNP work_j7kpdr5srze47kmsl2scd6h4c4 112 12 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 112 13 indicated indicate VBN work_j7kpdr5srze47kmsl2scd6h4c4 112 14 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 112 15 solid solid JJ work_j7kpdr5srze47kmsl2scd6h4c4 112 16 bars bar NNS work_j7kpdr5srze47kmsl2scd6h4c4 112 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 113 1 Peripherin Peripherin NNP work_j7kpdr5srze47kmsl2scd6h4c4 113 2 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 113 3 NF NF NNP work_j7kpdr5srze47kmsl2scd6h4c4 113 4 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 113 5 NF160 NF160 NNP work_j7kpdr5srze47kmsl2scd6h4c4 113 6 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 113 7 are be VBP work_j7kpdr5srze47kmsl2scd6h4c4 113 8 consistently consistently RB work_j7kpdr5srze47kmsl2scd6h4c4 113 9 expressed express VBN work_j7kpdr5srze47kmsl2scd6h4c4 113 10 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 113 11 d1 d1 RB work_j7kpdr5srze47kmsl2scd6h4c4 113 12 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 113 13 d6 d6 NN work_j7kpdr5srze47kmsl2scd6h4c4 113 14 . . . work_j7kpdr5srze47kmsl2scd6h4c4 114 1 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 114 2 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 114 3 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 114 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 114 5 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 114 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 114 7 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 114 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 115 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 115 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 115 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 115 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 116 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 2 3177 3177 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 3 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 116 4 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 116 5 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 116 6 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 116 7 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 116 8 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 116 9 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 116 10 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 11 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 12 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 13 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 116 14 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 116 15 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 116 16 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 116 17 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 116 18 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 116 19 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 116 20 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 116 21 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 116 22 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 23 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 24 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 25 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 26 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 27 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 28 - - : work_j7kpdr5srze47kmsl2scd6h4c4 116 29 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 116 30 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 116 31 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 32 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 116 33 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 34 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 35 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 116 36 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 116 37 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 116 38 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 39 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 40 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 41 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 42 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 43 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 44 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 116 45 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 116 46 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 47 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 116 48 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 49 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 50 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 51 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 52 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 53 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 54 , , , work_j7kpdr5srze47kmsl2scd6h4c4 116 55 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 56 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 57 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 58 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 116 59 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 116 60 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 116 61 : : : work_j7kpdr5srze47kmsl2scd6h4c4 116 62 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 63 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 64 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 65 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 116 66 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 67 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 68 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 69 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 70 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 116 71 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 116 72 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 116 73 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 74 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 75 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 76 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 77 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 116 78 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 79 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 116 80 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 81 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 82 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 83 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 84 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 85 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 116 86 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 116 87 lineage lineage NN work_j7kpdr5srze47kmsl2scd6h4c4 116 88 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 116 89 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 116 90 resulting result VBG work_j7kpdr5srze47kmsl2scd6h4c4 116 91 defect defect NN work_j7kpdr5srze47kmsl2scd6h4c4 116 92 may may MD work_j7kpdr5srze47kmsl2scd6h4c4 116 93 modify modify VB work_j7kpdr5srze47kmsl2scd6h4c4 116 94 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 116 95 respiratory respiratory JJ work_j7kpdr5srze47kmsl2scd6h4c4 116 96 network network NN work_j7kpdr5srze47kmsl2scd6h4c4 116 97 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 116 98 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 116 99 brainstem brainstem NN work_j7kpdr5srze47kmsl2scd6h4c4 116 100 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 116 101 periphery periphery NN work_j7kpdr5srze47kmsl2scd6h4c4 116 102 . . . work_j7kpdr5srze47kmsl2scd6h4c4 117 1 MATERIALS material NNS work_j7kpdr5srze47kmsl2scd6h4c4 117 2 AND and CC work_j7kpdr5srze47kmsl2scd6h4c4 117 3 METHODS methods JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 4 Patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 117 5 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 117 6 series series NN work_j7kpdr5srze47kmsl2scd6h4c4 117 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 117 8 30 30 CD work_j7kpdr5srze47kmsl2scd6h4c4 117 9 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 117 10 fulfilled fulfil VBD work_j7kpdr5srze47kmsl2scd6h4c4 117 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 117 12 inclusion inclusion NN work_j7kpdr5srze47kmsl2scd6h4c4 117 13 criteria criterion NNS work_j7kpdr5srze47kmsl2scd6h4c4 117 14 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 117 15 diagnosis diagnosis NN work_j7kpdr5srze47kmsl2scd6h4c4 117 16 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 117 17 CCHS CCHS NNP work_j7kpdr5srze47kmsl2scd6h4c4 117 18 namely namely RB work_j7kpdr5srze47kmsl2scd6h4c4 117 19 : : : work_j7kpdr5srze47kmsl2scd6h4c4 117 20 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 117 21 i i NN work_j7kpdr5srze47kmsl2scd6h4c4 117 22 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 117 23 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 117 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 117 25 hypoxemia hypoxemia NN work_j7kpdr5srze47kmsl2scd6h4c4 117 26 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 117 27 hypercarbia hypercarbia NNP work_j7kpdr5srze47kmsl2scd6h4c4 117 28 during during IN work_j7kpdr5srze47kmsl2scd6h4c4 117 29 quiet quiet JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 30 sleep sleep NN work_j7kpdr5srze47kmsl2scd6h4c4 117 31 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 117 32 polygraphic polygraphic JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 33 respiratory respiratory JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 34 recording recording NN work_j7kpdr5srze47kmsl2scd6h4c4 117 35 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 117 36 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 117 37 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 117 38 ii ii LS work_j7kpdr5srze47kmsl2scd6h4c4 117 39 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 117 40 no no DT work_j7kpdr5srze47kmsl2scd6h4c4 117 41 cardiac cardiac JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 42 , , , work_j7kpdr5srze47kmsl2scd6h4c4 117 43 pulmonary pulmonary JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 44 , , , work_j7kpdr5srze47kmsl2scd6h4c4 117 45 neuromuscular neuromuscular JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 46 , , , work_j7kpdr5srze47kmsl2scd6h4c4 117 47 EEG EEG NNP work_j7kpdr5srze47kmsl2scd6h4c4 117 48 or or CC work_j7kpdr5srze47kmsl2scd6h4c4 117 49 cerebral cerebral JJ work_j7kpdr5srze47kmsl2scd6h4c4 117 50 MRI MRI NNP work_j7kpdr5srze47kmsl2scd6h4c4 117 51 abnormality abnormality NN work_j7kpdr5srze47kmsl2scd6h4c4 117 52 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 117 53 17 17 CD work_j7kpdr5srze47kmsl2scd6h4c4 117 54 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 117 55 . . . work_j7kpdr5srze47kmsl2scd6h4c4 118 1 Haddad Haddad NNP work_j7kpdr5srze47kmsl2scd6h4c4 118 2 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 118 3 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 118 4 diagnosed diagnose VBN work_j7kpdr5srze47kmsl2scd6h4c4 118 5 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 118 6 11 11 CD work_j7kpdr5srze47kmsl2scd6h4c4 118 7 cases case NNS work_j7kpdr5srze47kmsl2scd6h4c4 118 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 118 9 36 36 CD work_j7kpdr5srze47kmsl2scd6h4c4 118 10 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 118 11 , , , work_j7kpdr5srze47kmsl2scd6h4c4 118 12 five five CD work_j7kpdr5srze47kmsl2scd6h4c4 118 13 long long JJ work_j7kpdr5srze47kmsl2scd6h4c4 118 14 segment segment NN work_j7kpdr5srze47kmsl2scd6h4c4 118 15 HSCR HSCR NNP work_j7kpdr5srze47kmsl2scd6h4c4 118 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 118 17 two two CD work_j7kpdr5srze47kmsl2scd6h4c4 118 18 short short JJ work_j7kpdr5srze47kmsl2scd6h4c4 118 19 segment segment NN work_j7kpdr5srze47kmsl2scd6h4c4 118 20 HSCR HSCR NNP work_j7kpdr5srze47kmsl2scd6h4c4 118 21 , , , work_j7kpdr5srze47kmsl2scd6h4c4 118 22 four four CD work_j7kpdr5srze47kmsl2scd6h4c4 118 23 unknown unknown NN work_j7kpdr5srze47kmsl2scd6h4c4 118 24 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 118 25 . . . work_j7kpdr5srze47kmsl2scd6h4c4 119 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 119 2 histological histological JJ work_j7kpdr5srze47kmsl2scd6h4c4 119 3 criteria criterion NNS work_j7kpdr5srze47kmsl2scd6h4c4 119 4 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 119 5 HSCR HSCR NNP work_j7kpdr5srze47kmsl2scd6h4c4 119 6 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 119 7 : : : work_j7kpdr5srze47kmsl2scd6h4c4 119 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 119 9 i i NN work_j7kpdr5srze47kmsl2scd6h4c4 119 10 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 119 11 absence absence NN work_j7kpdr5srze47kmsl2scd6h4c4 119 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 119 13 enteric enteric JJ work_j7kpdr5srze47kmsl2scd6h4c4 119 14 plexuses plexus NNS work_j7kpdr5srze47kmsl2scd6h4c4 119 15 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 119 16 histological histological JJ work_j7kpdr5srze47kmsl2scd6h4c4 119 17 evaluation evaluation NN work_j7kpdr5srze47kmsl2scd6h4c4 119 18 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 119 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 119 20 aganglionic aganglionic JJ work_j7kpdr5srze47kmsl2scd6h4c4 119 21 tract tract NN work_j7kpdr5srze47kmsl2scd6h4c4 119 22 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 119 23 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 119 24 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 119 25 ii ii NNP work_j7kpdr5srze47kmsl2scd6h4c4 119 26 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 119 27 strong strong JJ work_j7kpdr5srze47kmsl2scd6h4c4 119 28 histochemical histochemical JJ work_j7kpdr5srze47kmsl2scd6h4c4 119 29 staining staining NN work_j7kpdr5srze47kmsl2scd6h4c4 119 30 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 119 31 acetylcholinesterase acetylcholinesterase NN work_j7kpdr5srze47kmsl2scd6h4c4 119 32 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 119 33 nerve nerve NN work_j7kpdr5srze47kmsl2scd6h4c4 119 34 fibers fiber NNS work_j7kpdr5srze47kmsl2scd6h4c4 119 35 . . . work_j7kpdr5srze47kmsl2scd6h4c4 120 1 Blood blood NN work_j7kpdr5srze47kmsl2scd6h4c4 120 2 samples sample NNS work_j7kpdr5srze47kmsl2scd6h4c4 120 3 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 120 4 obtained obtain VBN work_j7kpdr5srze47kmsl2scd6h4c4 120 5 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 120 6 informed informed JJ work_j7kpdr5srze47kmsl2scd6h4c4 120 7 consent consent NN work_j7kpdr5srze47kmsl2scd6h4c4 120 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 120 9 DNA dna NN work_j7kpdr5srze47kmsl2scd6h4c4 120 10 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 120 11 extracted extract VBN work_j7kpdr5srze47kmsl2scd6h4c4 120 12 according accord VBG work_j7kpdr5srze47kmsl2scd6h4c4 120 13 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 120 14 standard standard JJ work_j7kpdr5srze47kmsl2scd6h4c4 120 15 protocols protocol NNS work_j7kpdr5srze47kmsl2scd6h4c4 120 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 121 1 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 121 2 screened screen VBD work_j7kpdr5srze47kmsl2scd6h4c4 121 3 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 121 4 coding code VBG work_j7kpdr5srze47kmsl2scd6h4c4 121 5 sequence sequence NN work_j7kpdr5srze47kmsl2scd6h4c4 121 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 121 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 121 8 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 121 9 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 121 10 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 121 11 single single JJ work_j7kpdr5srze47kmsl2scd6h4c4 121 12 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 121 13 strand strand NN work_j7kpdr5srze47kmsl2scd6h4c4 121 14 conformation conformation NN work_j7kpdr5srze47kmsl2scd6h4c4 121 15 polymorphism polymorphism NN work_j7kpdr5srze47kmsl2scd6h4c4 121 16 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 121 17 SSCP SSCP NNP work_j7kpdr5srze47kmsl2scd6h4c4 121 18 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 121 19 analysis analysis NN work_j7kpdr5srze47kmsl2scd6h4c4 121 20 and/or and/or CC work_j7kpdr5srze47kmsl2scd6h4c4 121 21 direct direct JJ work_j7kpdr5srze47kmsl2scd6h4c4 121 22 DNA dna NN work_j7kpdr5srze47kmsl2scd6h4c4 121 23 sequencing sequencing NN work_j7kpdr5srze47kmsl2scd6h4c4 121 24 . . . work_j7kpdr5srze47kmsl2scd6h4c4 122 1 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 122 2 PCR PCR NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 3 products product NNS work_j7kpdr5srze47kmsl2scd6h4c4 122 4 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 122 5 heated heat VBN work_j7kpdr5srze47kmsl2scd6h4c4 122 6 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 122 7 10 10 CD work_j7kpdr5srze47kmsl2scd6h4c4 122 8 min min NN work_j7kpdr5srze47kmsl2scd6h4c4 122 9 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 122 10 95 95 CD work_j7kpdr5srze47kmsl2scd6h4c4 122 11 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 12 C C NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 122 14 loaded load VBN work_j7kpdr5srze47kmsl2scd6h4c4 122 15 onto onto IN work_j7kpdr5srze47kmsl2scd6h4c4 122 16 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 122 17 Hydrolink Hydrolink NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 18 MDE MDE NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 19 gel gel NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 20 Figure Figure NNP work_j7kpdr5srze47kmsl2scd6h4c4 122 21 4 4 CD work_j7kpdr5srze47kmsl2scd6h4c4 122 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 123 1 Functional functional JJ work_j7kpdr5srze47kmsl2scd6h4c4 123 2 analysis analysis NN work_j7kpdr5srze47kmsl2scd6h4c4 123 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 123 4 indicating indicate VBG work_j7kpdr5srze47kmsl2scd6h4c4 123 5 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 123 6 decrease decrease NN work_j7kpdr5srze47kmsl2scd6h4c4 123 7 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 123 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 123 9 number number NN work_j7kpdr5srze47kmsl2scd6h4c4 123 10 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 123 11 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 123 12 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 123 13 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 123 14 obtained obtain VBN work_j7kpdr5srze47kmsl2scd6h4c4 123 15 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 123 16 NCSCs NCSCs NNPS work_j7kpdr5srze47kmsl2scd6h4c4 123 17 after after IN work_j7kpdr5srze47kmsl2scd6h4c4 123 18 forced force VBN work_j7kpdr5srze47kmsl2scd6h4c4 123 19 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 123 20 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 123 21 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 123 22 three three CD work_j7kpdr5srze47kmsl2scd6h4c4 123 23 mutated mutate VBN work_j7kpdr5srze47kmsl2scd6h4c4 123 24 forms form NNS work_j7kpdr5srze47kmsl2scd6h4c4 123 25 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 123 26 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 123 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 123 28 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 123 29 respect respect NN work_j7kpdr5srze47kmsl2scd6h4c4 123 30 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 123 31 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 123 32 wild wild JJ work_j7kpdr5srze47kmsl2scd6h4c4 123 33 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 123 34 type type NN work_j7kpdr5srze47kmsl2scd6h4c4 123 35 . . . work_j7kpdr5srze47kmsl2scd6h4c4 124 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 124 2 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 124 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 124 4 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 124 5 adenovirus adenovirus NN work_j7kpdr5srze47kmsl2scd6h4c4 124 6 constructs construct NNS work_j7kpdr5srze47kmsl2scd6h4c4 124 7 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 124 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 124 9 production production NN work_j7kpdr5srze47kmsl2scd6h4c4 124 10 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 124 11 both both CC work_j7kpdr5srze47kmsl2scd6h4c4 124 12 green green JJ work_j7kpdr5srze47kmsl2scd6h4c4 124 13 fluorescent fluorescent NN work_j7kpdr5srze47kmsl2scd6h4c4 124 14 protein protein NN work_j7kpdr5srze47kmsl2scd6h4c4 124 15 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 124 16 GFP GFP NNP work_j7kpdr5srze47kmsl2scd6h4c4 124 17 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 124 18 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 124 19 wild- wild- NN work_j7kpdr5srze47kmsl2scd6h4c4 124 20 type type NN work_j7kpdr5srze47kmsl2scd6h4c4 124 21 or or CC work_j7kpdr5srze47kmsl2scd6h4c4 124 22 mutated mutated JJ work_j7kpdr5srze47kmsl2scd6h4c4 124 23 forms form NNS work_j7kpdr5srze47kmsl2scd6h4c4 124 24 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 124 25 HASH1 HASH1 NNS work_j7kpdr5srze47kmsl2scd6h4c4 124 26 under under IN work_j7kpdr5srze47kmsl2scd6h4c4 124 27 cytomegalovirus cytomegalovirus NNP work_j7kpdr5srze47kmsl2scd6h4c4 124 28 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 124 29 CMV CMV NNP work_j7kpdr5srze47kmsl2scd6h4c4 124 30 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 124 31 promoter promoter NN work_j7kpdr5srze47kmsl2scd6h4c4 124 32 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 124 33 . . . work_j7kpdr5srze47kmsl2scd6h4c4 125 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 125 2 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 125 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 125 4 Left leave VBD work_j7kpdr5srze47kmsl2scd6h4c4 125 5 panel panel NN work_j7kpdr5srze47kmsl2scd6h4c4 125 6 : : : work_j7kpdr5srze47kmsl2scd6h4c4 125 7 representative representative JJ work_j7kpdr5srze47kmsl2scd6h4c4 125 8 samples sample NNS work_j7kpdr5srze47kmsl2scd6h4c4 125 9 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 125 10 infected infect VBN work_j7kpdr5srze47kmsl2scd6h4c4 125 11 NCSCs NCSCs NNP work_j7kpdr5srze47kmsl2scd6h4c4 125 12 24 24 CD work_j7kpdr5srze47kmsl2scd6h4c4 125 13 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 125 14 after after IN work_j7kpdr5srze47kmsl2scd6h4c4 125 15 infection infection NN work_j7kpdr5srze47kmsl2scd6h4c4 125 16 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 125 17 adenoviruses adenovirus NNS work_j7kpdr5srze47kmsl2scd6h4c4 125 18 producing produce VBG work_j7kpdr5srze47kmsl2scd6h4c4 125 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 125 20 wild wild JJ work_j7kpdr5srze47kmsl2scd6h4c4 125 21 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 125 22 type type NN work_j7kpdr5srze47kmsl2scd6h4c4 125 23 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 125 24 WT WT NNP work_j7kpdr5srze47kmsl2scd6h4c4 125 25 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 125 26 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 125 27 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 125 28 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 125 29 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 125 30 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 125 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 125 32 A36–A43del A36–A43del NNP work_j7kpdr5srze47kmsl2scd6h4c4 125 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 125 34 A37–A41del a37–a41del LS work_j7kpdr5srze47kmsl2scd6h4c4 125 35 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 125 36 forms form NNS work_j7kpdr5srze47kmsl2scd6h4c4 125 37 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 125 38 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 125 39 . . . work_j7kpdr5srze47kmsl2scd6h4c4 126 1 GFP GFP NNP work_j7kpdr5srze47kmsl2scd6h4c4 126 2 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 126 3 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 126 4 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 126 5 its -PRON- PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 126 6 green green JJ work_j7kpdr5srze47kmsl2scd6h4c4 126 7 fluorescence fluorescence NN work_j7kpdr5srze47kmsl2scd6h4c4 126 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 126 9 Phox2a phox2a NN work_j7kpdr5srze47kmsl2scd6h4c4 126 10 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 126 11 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 126 12 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 126 13 staining stain VBG work_j7kpdr5srze47kmsl2scd6h4c4 126 14 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 126 15 Fast fast JJ work_j7kpdr5srze47kmsl2scd6h4c4 126 16 Red Red NNP work_j7kpdr5srze47kmsl2scd6h4c4 126 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 127 1 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 127 2 typical typical JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 3 Phox2a phox2a JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 4 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 127 5 positive positive JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 6 cell cell NN work_j7kpdr5srze47kmsl2scd6h4c4 127 7 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 127 8 indicated indicate VBN work_j7kpdr5srze47kmsl2scd6h4c4 127 9 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 127 10 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 127 11 white white JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 12 arrow arrow NN work_j7kpdr5srze47kmsl2scd6h4c4 127 13 ; ; : work_j7kpdr5srze47kmsl2scd6h4c4 127 14 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 127 15 typical typical JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 16 Phox2a phox2a JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 127 18 negative negative JJ work_j7kpdr5srze47kmsl2scd6h4c4 127 19 cell cell NN work_j7kpdr5srze47kmsl2scd6h4c4 127 20 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 127 21 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 127 22 indicated indicate VBN work_j7kpdr5srze47kmsl2scd6h4c4 127 23 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 127 24 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 127 25 white white NNP work_j7kpdr5srze47kmsl2scd6h4c4 127 26 arrowhead arrowhead NN work_j7kpdr5srze47kmsl2scd6h4c4 127 27 . . . work_j7kpdr5srze47kmsl2scd6h4c4 128 1 Right right JJ work_j7kpdr5srze47kmsl2scd6h4c4 128 2 panel panel NN work_j7kpdr5srze47kmsl2scd6h4c4 128 3 : : : work_j7kpdr5srze47kmsl2scd6h4c4 128 4 percentage percentage NN work_j7kpdr5srze47kmsl2scd6h4c4 128 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 128 6 Phox2a phox2a PRP$ work_j7kpdr5srze47kmsl2scd6h4c4 128 7 positive positive JJ work_j7kpdr5srze47kmsl2scd6h4c4 128 8 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 128 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 128 10 illustrating illustrate VBG work_j7kpdr5srze47kmsl2scd6h4c4 128 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 128 12 decrease decrease NN work_j7kpdr5srze47kmsl2scd6h4c4 128 13 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 128 14 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 128 15 number number NN work_j7kpdr5srze47kmsl2scd6h4c4 128 16 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 128 17 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 128 18 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 128 19 obtained obtain VBN work_j7kpdr5srze47kmsl2scd6h4c4 128 20 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 128 21 NCSCs NCSCs NNPS work_j7kpdr5srze47kmsl2scd6h4c4 128 22 after after IN work_j7kpdr5srze47kmsl2scd6h4c4 128 23 infection infection NN work_j7kpdr5srze47kmsl2scd6h4c4 128 24 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 128 25 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 128 26 mutant mutant JJ work_j7kpdr5srze47kmsl2scd6h4c4 128 27 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 128 28 retroviral retroviral JJ work_j7kpdr5srze47kmsl2scd6h4c4 128 29 constructs construct NNS work_j7kpdr5srze47kmsl2scd6h4c4 128 30 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 128 31 P18 P18 NNP work_j7kpdr5srze47kmsl2scd6h4c4 128 32 T T NNP work_j7kpdr5srze47kmsl2scd6h4c4 128 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 128 34 A36–A43del A36–A43del NNP work_j7kpdr5srze47kmsl2scd6h4c4 128 35 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 128 36 A37–A41del A37–A41del NNP work_j7kpdr5srze47kmsl2scd6h4c4 128 37 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 128 38 . . . work_j7kpdr5srze47kmsl2scd6h4c4 129 1 3178 3178 CD work_j7kpdr5srze47kmsl2scd6h4c4 129 2 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 129 3 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 129 4 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 129 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 129 6 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 129 7 , , , work_j7kpdr5srze47kmsl2scd6h4c4 129 8 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 129 9 . . . work_j7kpdr5srze47kmsl2scd6h4c4 130 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 130 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 130 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 130 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 131 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 2 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 131 3 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 131 4 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 131 5 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 131 6 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 131 7 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 131 8 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 131 9 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 10 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 11 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 12 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 131 13 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 131 14 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 131 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 131 16 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 131 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 131 18 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 131 19 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 131 20 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 131 21 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 22 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 23 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 24 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 25 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 26 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 27 - - : work_j7kpdr5srze47kmsl2scd6h4c4 131 28 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 131 29 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 131 30 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 31 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 131 32 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 33 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 34 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 131 35 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 131 36 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 131 37 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 38 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 39 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 40 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 41 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 42 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 43 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 131 44 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 131 45 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 46 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 131 47 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 48 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 49 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 50 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 51 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 52 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 54 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 55 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 56 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 57 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 58 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 131 59 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 131 60 : : : work_j7kpdr5srze47kmsl2scd6h4c4 131 61 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 62 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 63 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 64 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 131 65 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 66 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 67 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 68 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 69 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 131 70 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 131 71 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 131 72 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 73 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 74 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 75 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 76 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 131 77 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 78 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 131 79 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 80 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 81 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 82 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 83 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 84 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 85 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 131 86 Bioprobe Bioprobe NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 87 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 131 88 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 89 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 131 90 subjected subject VBN work_j7kpdr5srze47kmsl2scd6h4c4 131 91 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 131 92 electrophoresis electrophoresis NN work_j7kpdr5srze47kmsl2scd6h4c4 131 93 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 131 94 4 4 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 95 W. W. NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 96 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 131 97 gel gel NN work_j7kpdr5srze47kmsl2scd6h4c4 131 98 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 131 99 then then RB work_j7kpdr5srze47kmsl2scd6h4c4 131 100 dried dry VBN work_j7kpdr5srze47kmsl2scd6h4c4 131 101 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 131 102 placed place VBN work_j7kpdr5srze47kmsl2scd6h4c4 131 103 against against IN work_j7kpdr5srze47kmsl2scd6h4c4 131 104 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 131 105 X X NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 106 - - NN work_j7kpdr5srze47kmsl2scd6h4c4 131 107 ray ray NN work_j7kpdr5srze47kmsl2scd6h4c4 131 108 film film NN work_j7kpdr5srze47kmsl2scd6h4c4 131 109 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 131 110 48 48 CD work_j7kpdr5srze47kmsl2scd6h4c4 131 111 h. h. NNS work_j7kpdr5srze47kmsl2scd6h4c4 131 112 If if IN work_j7kpdr5srze47kmsl2scd6h4c4 131 113 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 131 114 abnormal abnormal JJ work_j7kpdr5srze47kmsl2scd6h4c4 131 115 SSCP sscp JJ work_j7kpdr5srze47kmsl2scd6h4c4 131 116 pattern pattern NN work_j7kpdr5srze47kmsl2scd6h4c4 131 117 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 131 118 observed observe VBN work_j7kpdr5srze47kmsl2scd6h4c4 131 119 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 120 direct direct JJ work_j7kpdr5srze47kmsl2scd6h4c4 131 121 DNA DNA NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 122 sequencing sequencing NN work_j7kpdr5srze47kmsl2scd6h4c4 131 123 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 131 124 performed perform VBN work_j7kpdr5srze47kmsl2scd6h4c4 131 125 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 131 126 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 131 127 fluorometric fluorometric JJ work_j7kpdr5srze47kmsl2scd6h4c4 131 128 method method NN work_j7kpdr5srze47kmsl2scd6h4c4 131 129 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 130 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 131 131 both both DT work_j7kpdr5srze47kmsl2scd6h4c4 131 132 strands strand NNS work_j7kpdr5srze47kmsl2scd6h4c4 131 133 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 131 134 Big Big NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 135 DyeTerminator DyeTerminator NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 136 Cycle Cycle NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 137 Sequencing Sequencing NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 138 kit kit NN work_j7kpdr5srze47kmsl2scd6h4c4 131 139 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 140 Applied Applied NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 141 Biosystems Biosystems NNPS work_j7kpdr5srze47kmsl2scd6h4c4 131 142 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 143 Warrington Warrington NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 144 , , , work_j7kpdr5srze47kmsl2scd6h4c4 131 145 UK UK NNP work_j7kpdr5srze47kmsl2scd6h4c4 131 146 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 131 147 . . . work_j7kpdr5srze47kmsl2scd6h4c4 132 1 In in IN work_j7kpdr5srze47kmsl2scd6h4c4 132 2 situ situ JJ work_j7kpdr5srze47kmsl2scd6h4c4 132 3 hybridization hybridization NN work_j7kpdr5srze47kmsl2scd6h4c4 132 4 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 132 5 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 132 6 embryos embryo NNS work_j7kpdr5srze47kmsl2scd6h4c4 132 7 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 132 8 embryos embryo NNS work_j7kpdr5srze47kmsl2scd6h4c4 132 9 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 132 10 fetal fetal JJ work_j7kpdr5srze47kmsl2scd6h4c4 132 11 tissues tissue NNS work_j7kpdr5srze47kmsl2scd6h4c4 132 12 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 132 13 collected collect VBN work_j7kpdr5srze47kmsl2scd6h4c4 132 14 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 132 15 legally legally RB work_j7kpdr5srze47kmsl2scd6h4c4 132 16 terminated terminate VBN work_j7kpdr5srze47kmsl2scd6h4c4 132 17 pregnancies pregnancy NNS work_j7kpdr5srze47kmsl2scd6h4c4 132 18 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 132 19 agreement agreement NN work_j7kpdr5srze47kmsl2scd6h4c4 132 20 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 132 21 French french JJ work_j7kpdr5srze47kmsl2scd6h4c4 132 22 law law NN work_j7kpdr5srze47kmsl2scd6h4c4 132 23 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 132 24 ethics ethic NNS work_j7kpdr5srze47kmsl2scd6h4c4 132 25 committee committee NN work_j7kpdr5srze47kmsl2scd6h4c4 132 26 recommendations recommendation NNS work_j7kpdr5srze47kmsl2scd6h4c4 132 27 . . . work_j7kpdr5srze47kmsl2scd6h4c4 133 1 Tissues tissue NNS work_j7kpdr5srze47kmsl2scd6h4c4 133 2 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 133 3 prepared prepare VBN work_j7kpdr5srze47kmsl2scd6h4c4 133 4 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 133 5 previously previously RB work_j7kpdr5srze47kmsl2scd6h4c4 133 6 described describe VBN work_j7kpdr5srze47kmsl2scd6h4c4 133 7 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 133 8 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 133 9 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 133 10 . . . work_j7kpdr5srze47kmsl2scd6h4c4 134 1 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 134 2 222 222 CD work_j7kpdr5srze47kmsl2scd6h4c4 134 3 bp bp NN work_j7kpdr5srze47kmsl2scd6h4c4 134 4 PCR PCR NNP work_j7kpdr5srze47kmsl2scd6h4c4 134 5 fragment fragment NN work_j7kpdr5srze47kmsl2scd6h4c4 134 6 correspon- correspon- NN work_j7kpdr5srze47kmsl2scd6h4c4 134 7 ding ding NNP work_j7kpdr5srze47kmsl2scd6h4c4 134 8 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 134 9 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 134 10 exon exon NNP work_j7kpdr5srze47kmsl2scd6h4c4 134 11 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 134 12 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 134 13 amplified amplify VBN work_j7kpdr5srze47kmsl2scd6h4c4 134 14 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 134 15 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 134 16 genomic genomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 134 17 DNA dna NN work_j7kpdr5srze47kmsl2scd6h4c4 134 18 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 134 19 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 134 20 T7 t7 NN work_j7kpdr5srze47kmsl2scd6h4c4 134 21 extension extension NN work_j7kpdr5srze47kmsl2scd6h4c4 134 22 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 134 23 TAATACGACTCACTAGGGAGA TAATACGACTCACTAGGGAGA NNP work_j7kpdr5srze47kmsl2scd6h4c4 134 24 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 134 25 added add VBD work_j7kpdr5srze47kmsl2scd6h4c4 134 26 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 134 27 both both DT work_j7kpdr5srze47kmsl2scd6h4c4 134 28 primers primer NNS work_j7kpdr5srze47kmsl2scd6h4c4 134 29 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 134 30 generate generate VB work_j7kpdr5srze47kmsl2scd6h4c4 134 31 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 134 32 sense sense NN work_j7kpdr5srze47kmsl2scd6h4c4 134 33 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 134 34 antisense antisense NN work_j7kpdr5srze47kmsl2scd6h4c4 134 35 probes probe NNS work_j7kpdr5srze47kmsl2scd6h4c4 134 36 . . . work_j7kpdr5srze47kmsl2scd6h4c4 135 1 Probes probe NNS work_j7kpdr5srze47kmsl2scd6h4c4 135 2 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 135 3 labeled label VBN work_j7kpdr5srze47kmsl2scd6h4c4 135 4 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 135 5 [ [ -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 135 6 35 35 CD work_j7kpdr5srze47kmsl2scd6h4c4 135 7 S]UTP s]utp NN work_j7kpdr5srze47kmsl2scd6h4c4 135 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 135 9 purified purify VBD work_j7kpdr5srze47kmsl2scd6h4c4 135 10 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 135 11 pre- pre- NN work_j7kpdr5srze47kmsl2scd6h4c4 135 12 viously viously RB work_j7kpdr5srze47kmsl2scd6h4c4 135 13 described describe VBN work_j7kpdr5srze47kmsl2scd6h4c4 135 14 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 135 15 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 135 16 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 135 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 136 1 Tissues tissue NNS work_j7kpdr5srze47kmsl2scd6h4c4 136 2 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 136 3 slides slide NNS work_j7kpdr5srze47kmsl2scd6h4c4 136 4 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 136 5 dehydrated dehydrate VBN work_j7kpdr5srze47kmsl2scd6h4c4 136 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 136 7 placed place VBN work_j7kpdr5srze47kmsl2scd6h4c4 136 8 against against IN work_j7kpdr5srze47kmsl2scd6h4c4 136 9 BIOMAX BIOMAX NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 10 MR MR NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 11 X X NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 12 - - NN work_j7kpdr5srze47kmsl2scd6h4c4 136 13 ray ray NN work_j7kpdr5srze47kmsl2scd6h4c4 136 14 film film NN work_j7kpdr5srze47kmsl2scd6h4c4 136 15 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 136 16 Amersham Amersham NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 17 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 136 18 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 136 19 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 136 20 days day NNS work_j7kpdr5srze47kmsl2scd6h4c4 136 21 , , , work_j7kpdr5srze47kmsl2scd6h4c4 136 22 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 136 23 immersed immerse VBD work_j7kpdr5srze47kmsl2scd6h4c4 136 24 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 136 25 Kodak Kodak NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 26 NTB2 NTB2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 27 emulsion emulsion NN work_j7kpdr5srze47kmsl2scd6h4c4 136 28 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 136 29 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 136 30 weeks week NNS work_j7kpdr5srze47kmsl2scd6h4c4 136 31 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 136 32 þ4 þ4 NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 33 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 136 34 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 137 1 Developed developed JJ work_j7kpdr5srze47kmsl2scd6h4c4 137 2 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 137 3 toluidine toluidine JJ work_j7kpdr5srze47kmsl2scd6h4c4 137 4 blue blue JJ work_j7kpdr5srze47kmsl2scd6h4c4 137 5 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 137 6 counterstained counterstaine VBN work_j7kpdr5srze47kmsl2scd6h4c4 137 7 slides slide NNS work_j7kpdr5srze47kmsl2scd6h4c4 137 8 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 137 9 analyzed analyze VBN work_j7kpdr5srze47kmsl2scd6h4c4 137 10 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 137 11 dark- dark- JJ work_j7kpdr5srze47kmsl2scd6h4c4 137 12 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 137 13 bright bright JJ work_j7kpdr5srze47kmsl2scd6h4c4 137 14 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 137 15 field field NN work_j7kpdr5srze47kmsl2scd6h4c4 137 16 illumination illumination NN work_j7kpdr5srze47kmsl2scd6h4c4 137 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 138 1 No no DT work_j7kpdr5srze47kmsl2scd6h4c4 138 2 hybridiza- hybridiza- JJ work_j7kpdr5srze47kmsl2scd6h4c4 138 3 tion tion NN work_j7kpdr5srze47kmsl2scd6h4c4 138 4 signal signal NN work_j7kpdr5srze47kmsl2scd6h4c4 138 5 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 138 6 detected detect VBN work_j7kpdr5srze47kmsl2scd6h4c4 138 7 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 138 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 138 9 sense sense NN work_j7kpdr5srze47kmsl2scd6h4c4 138 10 probe probe NN work_j7kpdr5srze47kmsl2scd6h4c4 138 11 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 138 12 data datum NNS work_j7kpdr5srze47kmsl2scd6h4c4 138 13 not not RB work_j7kpdr5srze47kmsl2scd6h4c4 138 14 shown show VBN work_j7kpdr5srze47kmsl2scd6h4c4 138 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 138 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 139 1 Construction construction NN work_j7kpdr5srze47kmsl2scd6h4c4 139 2 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 139 3 adenoviral adenoviral NN work_j7kpdr5srze47kmsl2scd6h4c4 139 4 plasmids plasmid NNS work_j7kpdr5srze47kmsl2scd6h4c4 139 5 Adenoviral Adenoviral NNP work_j7kpdr5srze47kmsl2scd6h4c4 139 6 plasmids plasmid NNS work_j7kpdr5srze47kmsl2scd6h4c4 139 7 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 139 8 constructed construct VBN work_j7kpdr5srze47kmsl2scd6h4c4 139 9 using use VBG work_j7kpdr5srze47kmsl2scd6h4c4 139 10 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 139 11 Adeasy Adeasy NNP work_j7kpdr5srze47kmsl2scd6h4c4 139 12 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 139 13 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 139 14 19 19 CD work_j7kpdr5srze47kmsl2scd6h4c4 139 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 139 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 140 1 Polyalanine polyalanine JJ work_j7kpdr5srze47kmsl2scd6h4c4 140 2 tract tract NN work_j7kpdr5srze47kmsl2scd6h4c4 140 3 contractions contraction NNS work_j7kpdr5srze47kmsl2scd6h4c4 140 4 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 140 5 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 140 6 control control NN work_j7kpdr5srze47kmsl2scd6h4c4 140 7 HASH-1 HASH-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 140 8 coding code VBG work_j7kpdr5srze47kmsl2scd6h4c4 140 9 sequence sequence NN work_j7kpdr5srze47kmsl2scd6h4c4 140 10 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 140 11 amplified amplify VBN work_j7kpdr5srze47kmsl2scd6h4c4 140 12 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 140 13 polymerase polymerase NN work_j7kpdr5srze47kmsl2scd6h4c4 140 14 chain chain NN work_j7kpdr5srze47kmsl2scd6h4c4 140 15 reaction reaction NN work_j7kpdr5srze47kmsl2scd6h4c4 140 16 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 140 17 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 140 18 50 50 CD work_j7kpdr5srze47kmsl2scd6h4c4 140 19 primer primer NN work_j7kpdr5srze47kmsl2scd6h4c4 140 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 140 21 TCTAGACGCATGGAAA- TCTAGACGCATGGAAA- NNP work_j7kpdr5srze47kmsl2scd6h4c4 140 22 GCTCTGCCAA GCTCTGCCAA NNP work_j7kpdr5srze47kmsl2scd6h4c4 140 23 , , , work_j7kpdr5srze47kmsl2scd6h4c4 140 24 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 140 25 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 140 26 30 30 CD work_j7kpdr5srze47kmsl2scd6h4c4 140 27 primer primer NN work_j7kpdr5srze47kmsl2scd6h4c4 140 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 140 29 GTCGACTCAGAACC- GTCGACTCAGAACC- NNP work_j7kpdr5srze47kmsl2scd6h4c4 140 30 AGTTGGTGAAGTCGA AGTTGGTGAAGTCGA NNP work_j7kpdr5srze47kmsl2scd6h4c4 140 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 140 32 using use VBG work_j7kpdr5srze47kmsl2scd6h4c4 140 33 genomic genomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 140 34 DNA dna NN work_j7kpdr5srze47kmsl2scd6h4c4 140 35 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 140 36 controls control NNS work_j7kpdr5srze47kmsl2scd6h4c4 140 37 or or CC work_j7kpdr5srze47kmsl2scd6h4c4 140 38 patients patient NNS work_j7kpdr5srze47kmsl2scd6h4c4 140 39 . . . work_j7kpdr5srze47kmsl2scd6h4c4 141 1 PCR PCR NNP work_j7kpdr5srze47kmsl2scd6h4c4 141 2 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 141 3 derived derive VBN work_j7kpdr5srze47kmsl2scd6h4c4 141 4 fragments fragment NNS work_j7kpdr5srze47kmsl2scd6h4c4 141 5 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 141 6 checked check VBN work_j7kpdr5srze47kmsl2scd6h4c4 141 7 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 141 8 sequen- sequen- NN work_j7kpdr5srze47kmsl2scd6h4c4 141 9 cing cing NN work_j7kpdr5srze47kmsl2scd6h4c4 141 10 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 141 11 subcloned subclone VBN work_j7kpdr5srze47kmsl2scd6h4c4 141 12 into into IN work_j7kpdr5srze47kmsl2scd6h4c4 141 13 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 141 14 pAd pad NN work_j7kpdr5srze47kmsl2scd6h4c4 141 15 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 141 16 track track NN work_j7kpdr5srze47kmsl2scd6h4c4 141 17 CMV CMV NNP work_j7kpdr5srze47kmsl2scd6h4c4 141 18 vector vector NN work_j7kpdr5srze47kmsl2scd6h4c4 141 19 , , , work_j7kpdr5srze47kmsl2scd6h4c4 141 20 using use VBG work_j7kpdr5srze47kmsl2scd6h4c4 141 21 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 141 22 XbaI XbaI NNPS work_j7kpdr5srze47kmsl2scd6h4c4 141 23 – – : work_j7kpdr5srze47kmsl2scd6h4c4 141 24 SalI SalI NNP work_j7kpdr5srze47kmsl2scd6h4c4 141 25 restriction restriction NN work_j7kpdr5srze47kmsl2scd6h4c4 141 26 sites site NNS work_j7kpdr5srze47kmsl2scd6h4c4 141 27 . . . work_j7kpdr5srze47kmsl2scd6h4c4 142 1 PAd PAd NNS work_j7kpdr5srze47kmsl2scd6h4c4 142 2 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 142 3 track track VBP work_j7kpdr5srze47kmsl2scd6h4c4 142 4 CMV CMV NNP work_j7kpdr5srze47kmsl2scd6h4c4 142 5 vectors vector NNS work_j7kpdr5srze47kmsl2scd6h4c4 142 6 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 142 7 used use VBN work_j7kpdr5srze47kmsl2scd6h4c4 142 8 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 142 9 produce produce VB work_j7kpdr5srze47kmsl2scd6h4c4 142 10 viruses virus NNS work_j7kpdr5srze47kmsl2scd6h4c4 142 11 that that WDT work_j7kpdr5srze47kmsl2scd6h4c4 142 12 could could MD work_j7kpdr5srze47kmsl2scd6h4c4 142 13 be be VB work_j7kpdr5srze47kmsl2scd6h4c4 142 14 tracked track VBN work_j7kpdr5srze47kmsl2scd6h4c4 142 15 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 142 16 following follow VBG work_j7kpdr5srze47kmsl2scd6h4c4 142 17 GFP GFP NNP work_j7kpdr5srze47kmsl2scd6h4c4 142 18 fluorescence fluorescence NN work_j7kpdr5srze47kmsl2scd6h4c4 142 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 143 1 Adenoviral adenoviral NN work_j7kpdr5srze47kmsl2scd6h4c4 143 2 plasmids plasmid NNS work_j7kpdr5srze47kmsl2scd6h4c4 143 3 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 143 4 generated generate VBN work_j7kpdr5srze47kmsl2scd6h4c4 143 5 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 143 6 homologous homologous JJ work_j7kpdr5srze47kmsl2scd6h4c4 143 7 recombination recombination NN work_j7kpdr5srze47kmsl2scd6h4c4 143 8 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 143 9 electrocompetent electrocompetent NN work_j7kpdr5srze47kmsl2scd6h4c4 143 10 E. E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 143 11 coli coli NNS work_j7kpdr5srze47kmsl2scd6h4c4 143 12 BJ5183 BJ5183 NNP work_j7kpdr5srze47kmsl2scd6h4c4 143 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 143 14 according accord VBG work_j7kpdr5srze47kmsl2scd6h4c4 143 15 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 143 16 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 143 17 manufacturer manufacturer NN work_j7kpdr5srze47kmsl2scd6h4c4 143 18 ’s ’s POS work_j7kpdr5srze47kmsl2scd6h4c4 143 19 instructions instruction NNS work_j7kpdr5srze47kmsl2scd6h4c4 143 20 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 143 21 Stratagene Stratagene NNP work_j7kpdr5srze47kmsl2scd6h4c4 143 22 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 143 23 . . . work_j7kpdr5srze47kmsl2scd6h4c4 144 1 Adenoviral adenoviral JJ work_j7kpdr5srze47kmsl2scd6h4c4 144 2 plasmids plasmid NNS work_j7kpdr5srze47kmsl2scd6h4c4 144 3 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 144 4 then then RB work_j7kpdr5srze47kmsl2scd6h4c4 144 5 cut cut VBN work_j7kpdr5srze47kmsl2scd6h4c4 144 6 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 144 7 PacI PacI NNP work_j7kpdr5srze47kmsl2scd6h4c4 144 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 144 9 viral viral JJ work_j7kpdr5srze47kmsl2scd6h4c4 144 10 stocks stock NNS work_j7kpdr5srze47kmsl2scd6h4c4 144 11 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 144 12 produced produce VBN work_j7kpdr5srze47kmsl2scd6h4c4 144 13 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 144 14 QBI-293A QBI-293A NNP work_j7kpdr5srze47kmsl2scd6h4c4 144 15 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 144 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 145 1 Mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 145 2 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 145 3 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 145 4 culture culture NN work_j7kpdr5srze47kmsl2scd6h4c4 145 5 Neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 145 6 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 145 7 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 145 8 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 145 9 cultured culture VBN work_j7kpdr5srze47kmsl2scd6h4c4 145 10 as as IN work_j7kpdr5srze47kmsl2scd6h4c4 145 11 previously previously RB work_j7kpdr5srze47kmsl2scd6h4c4 145 12 described describe VBN work_j7kpdr5srze47kmsl2scd6h4c4 145 13 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 145 14 20 20 CD work_j7kpdr5srze47kmsl2scd6h4c4 145 15 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 145 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 146 1 Neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 146 2 tubes tube NNS work_j7kpdr5srze47kmsl2scd6h4c4 146 3 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 146 4 microdissected microdissecte VBN work_j7kpdr5srze47kmsl2scd6h4c4 146 5 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 146 6 Swiss swiss JJ work_j7kpdr5srze47kmsl2scd6h4c4 146 7 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 146 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 146 9 Iffa Iffa NNP work_j7kpdr5srze47kmsl2scd6h4c4 146 10 Credo Credo NNP work_j7kpdr5srze47kmsl2scd6h4c4 146 11 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 146 12 embryos embryo NNS work_j7kpdr5srze47kmsl2scd6h4c4 146 13 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 146 14 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 146 15 9 9 CD work_j7kpdr5srze47kmsl2scd6h4c4 146 16 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 146 17 gestation gestation NN work_j7kpdr5srze47kmsl2scd6h4c4 146 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 147 1 Somites somite NNS work_j7kpdr5srze47kmsl2scd6h4c4 147 2 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 147 3 surrounding surround VBG work_j7kpdr5srze47kmsl2scd6h4c4 147 4 tissues tissue NNS work_j7kpdr5srze47kmsl2scd6h4c4 147 5 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 147 6 removed remove VBN work_j7kpdr5srze47kmsl2scd6h4c4 147 7 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 147 8 obtain obtain VB work_j7kpdr5srze47kmsl2scd6h4c4 147 9 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 147 10 tube tube NN work_j7kpdr5srze47kmsl2scd6h4c4 147 11 segments segment NNS work_j7kpdr5srze47kmsl2scd6h4c4 147 12 corresponding correspond VBG work_j7kpdr5srze47kmsl2scd6h4c4 147 13 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 147 14 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 147 15 first first JJ work_j7kpdr5srze47kmsl2scd6h4c4 147 16 seven seven CD work_j7kpdr5srze47kmsl2scd6h4c4 147 17 somites somite NNS work_j7kpdr5srze47kmsl2scd6h4c4 147 18 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 147 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 147 20 vagal vagal JJ work_j7kpdr5srze47kmsl2scd6h4c4 147 21 region region NN work_j7kpdr5srze47kmsl2scd6h4c4 147 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 148 1 These these DT work_j7kpdr5srze47kmsl2scd6h4c4 148 2 segments segment NNS work_j7kpdr5srze47kmsl2scd6h4c4 148 3 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 148 4 then then RB work_j7kpdr5srze47kmsl2scd6h4c4 148 5 plated plate VBN work_j7kpdr5srze47kmsl2scd6h4c4 148 6 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 148 7 fibronectin fibronectin NN work_j7kpdr5srze47kmsl2scd6h4c4 148 8 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 148 9 coated coated JJ work_j7kpdr5srze47kmsl2scd6h4c4 148 10 glass glass NN work_j7kpdr5srze47kmsl2scd6h4c4 148 11 coverslips coverslip NNS work_j7kpdr5srze47kmsl2scd6h4c4 148 12 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 13 10 10 CD work_j7kpdr5srze47kmsl2scd6h4c4 148 14 mg mg NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 15 / / SYM work_j7kpdr5srze47kmsl2scd6h4c4 148 16 ml ml NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 17 , , , work_j7kpdr5srze47kmsl2scd6h4c4 148 18 Boehringer Boehringer NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 19 Roche Roche NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 20 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 21 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 148 22 cultured culture VBN work_j7kpdr5srze47kmsl2scd6h4c4 148 23 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 148 24 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 148 25 days day NNS work_j7kpdr5srze47kmsl2scd6h4c4 148 26 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 148 27 DMEM DMEM NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 28 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 29 Life Life NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 30 Technologies Technologies NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 31 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 32 supplemented supplement VBD work_j7kpdr5srze47kmsl2scd6h4c4 148 33 with with IN work_j7kpdr5srze47kmsl2scd6h4c4 148 34 10 10 CD work_j7kpdr5srze47kmsl2scd6h4c4 148 35 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 148 36 fetal fetal JJ work_j7kpdr5srze47kmsl2scd6h4c4 148 37 calf calf NN work_j7kpdr5srze47kmsl2scd6h4c4 148 38 serum serum NN work_j7kpdr5srze47kmsl2scd6h4c4 148 39 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 40 AbCys AbCys NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 41 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 42 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 148 43 100 100 CD work_j7kpdr5srze47kmsl2scd6h4c4 148 44 IU IU NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 45 / / SYM work_j7kpdr5srze47kmsl2scd6h4c4 148 46 ml ml NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 47 penicillin penicillin NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 48 / / SYM work_j7kpdr5srze47kmsl2scd6h4c4 148 49 streptomycin streptomycin NN work_j7kpdr5srze47kmsl2scd6h4c4 148 50 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 51 Life Life NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 52 Technologies Technologies NNPS work_j7kpdr5srze47kmsl2scd6h4c4 148 53 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 148 54 , , , work_j7kpdr5srze47kmsl2scd6h4c4 148 55 at at IN work_j7kpdr5srze47kmsl2scd6h4c4 148 56 37 37 CD work_j7kpdr5srze47kmsl2scd6h4c4 148 57 � � NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 58 C C NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 59 , , , work_j7kpdr5srze47kmsl2scd6h4c4 148 60 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 148 61 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 148 62 humidified humidified JJ work_j7kpdr5srze47kmsl2scd6h4c4 148 63 atmosphere atmosphere NN work_j7kpdr5srze47kmsl2scd6h4c4 148 64 containing contain VBG work_j7kpdr5srze47kmsl2scd6h4c4 148 65 5 5 CD work_j7kpdr5srze47kmsl2scd6h4c4 148 66 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 148 67 CO2 CO2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 148 68 . . . work_j7kpdr5srze47kmsl2scd6h4c4 149 1 Infection infection NN work_j7kpdr5srze47kmsl2scd6h4c4 149 2 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 149 3 primary primary JJ work_j7kpdr5srze47kmsl2scd6h4c4 149 4 cultures culture NNS work_j7kpdr5srze47kmsl2scd6h4c4 149 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 149 6 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 149 7 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 149 8 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 149 9 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 149 10 tested test VBD work_j7kpdr5srze47kmsl2scd6h4c4 149 11 various various JJ work_j7kpdr5srze47kmsl2scd6h4c4 149 12 levels level NNS work_j7kpdr5srze47kmsl2scd6h4c4 149 13 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 149 14 multiplicity multiplicity NN work_j7kpdr5srze47kmsl2scd6h4c4 149 15 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 149 16 infection infection NN work_j7kpdr5srze47kmsl2scd6h4c4 149 17 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 149 18 MOI MOI NNP work_j7kpdr5srze47kmsl2scd6h4c4 149 19 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 149 20 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 149 21 decided decide VBD work_j7kpdr5srze47kmsl2scd6h4c4 149 22 to to TO work_j7kpdr5srze47kmsl2scd6h4c4 149 23 use use VB work_j7kpdr5srze47kmsl2scd6h4c4 149 24 2000 2000 CD work_j7kpdr5srze47kmsl2scd6h4c4 149 25 plaque plaque NN work_j7kpdr5srze47kmsl2scd6h4c4 149 26 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 149 27 forming form VBG work_j7kpdr5srze47kmsl2scd6h4c4 149 28 unit unit NN work_j7kpdr5srze47kmsl2scd6h4c4 149 29 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 149 30 pfu pfu NNP work_j7kpdr5srze47kmsl2scd6h4c4 149 31 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 149 32 , , , work_j7kpdr5srze47kmsl2scd6h4c4 149 33 which which WDT work_j7kpdr5srze47kmsl2scd6h4c4 149 34 gave give VBD work_j7kpdr5srze47kmsl2scd6h4c4 149 35 100 100 CD work_j7kpdr5srze47kmsl2scd6h4c4 149 36 % % NN work_j7kpdr5srze47kmsl2scd6h4c4 149 37 infected infect VBN work_j7kpdr5srze47kmsl2scd6h4c4 149 38 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 149 39 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 149 40 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 149 41 . . . work_j7kpdr5srze47kmsl2scd6h4c4 150 1 Neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 150 2 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 150 3 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 150 4 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 150 5 NCCs NCCs NNPS work_j7kpdr5srze47kmsl2scd6h4c4 150 6 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 150 7 were be VBD work_j7kpdr5srze47kmsl2scd6h4c4 150 8 cultured culture VBN work_j7kpdr5srze47kmsl2scd6h4c4 150 9 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 150 10 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 150 11 days day NNS work_j7kpdr5srze47kmsl2scd6h4c4 150 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 150 13 infected infect VBN work_j7kpdr5srze47kmsl2scd6h4c4 150 14 on on IN work_j7kpdr5srze47kmsl2scd6h4c4 150 15 day day NN work_j7kpdr5srze47kmsl2scd6h4c4 150 16 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 150 17 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 150 18 fixed fix VBN work_j7kpdr5srze47kmsl2scd6h4c4 150 19 24 24 CD work_j7kpdr5srze47kmsl2scd6h4c4 150 20 h h NNS work_j7kpdr5srze47kmsl2scd6h4c4 150 21 later later RB work_j7kpdr5srze47kmsl2scd6h4c4 150 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 151 1 ACKNOWLEDGEMENTS ACKNOWLEDGEMENTS NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 2 We -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 151 3 thank thank VBP work_j7kpdr5srze47kmsl2scd6h4c4 151 4 Bert Bert NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 5 Vogelstein Vogelstein NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 6 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 151 7 adenoviral adenoviral NN work_j7kpdr5srze47kmsl2scd6h4c4 151 8 constructs construct NNS work_j7kpdr5srze47kmsl2scd6h4c4 151 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 151 10 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 151 11 Frances Frances NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 12 Goodman Goodman NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 13 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 151 14 Jean Jean NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 15 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 151 16 François François NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 17 Brunet Brunet NNP work_j7kpdr5srze47kmsl2scd6h4c4 151 18 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 151 19 helpful helpful JJ work_j7kpdr5srze47kmsl2scd6h4c4 151 20 discussions discussion NNS work_j7kpdr5srze47kmsl2scd6h4c4 151 21 . . . work_j7kpdr5srze47kmsl2scd6h4c4 152 1 H.A. H.A. NNP work_j7kpdr5srze47kmsl2scd6h4c4 153 1 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 153 2 recipient recipient JJ work_j7kpdr5srze47kmsl2scd6h4c4 153 3 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 153 4 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 153 5 IFRO ifro JJ work_j7kpdr5srze47kmsl2scd6h4c4 153 6 fellowship fellowship NN work_j7kpdr5srze47kmsl2scd6h4c4 153 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 154 1 V.N. V.N. NNP work_j7kpdr5srze47kmsl2scd6h4c4 155 1 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 155 2 partly partly RB work_j7kpdr5srze47kmsl2scd6h4c4 155 3 supported support VBN work_j7kpdr5srze47kmsl2scd6h4c4 155 4 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 155 5 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 155 6 Fondation Fondation NNP work_j7kpdr5srze47kmsl2scd6h4c4 155 7 pour pour VB work_j7kpdr5srze47kmsl2scd6h4c4 155 8 la la FW work_j7kpdr5srze47kmsl2scd6h4c4 155 9 Recherche Recherche NNP work_j7kpdr5srze47kmsl2scd6h4c4 155 10 Médicale Médicale NNP work_j7kpdr5srze47kmsl2scd6h4c4 155 11 fellowship fellowship NN work_j7kpdr5srze47kmsl2scd6h4c4 155 12 . . . work_j7kpdr5srze47kmsl2scd6h4c4 156 1 This this DT work_j7kpdr5srze47kmsl2scd6h4c4 156 2 work work NN work_j7kpdr5srze47kmsl2scd6h4c4 156 3 was be VBD work_j7kpdr5srze47kmsl2scd6h4c4 156 4 supported support VBN work_j7kpdr5srze47kmsl2scd6h4c4 156 5 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 156 6 grants grant NNS work_j7kpdr5srze47kmsl2scd6h4c4 156 7 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 156 8 EURExpress EURExpress NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 9 , , , work_j7kpdr5srze47kmsl2scd6h4c4 156 10 HMR HMR NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 11 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 156 12 Hoechst Hoechst NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 13 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 156 14 Marion Marion NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 15 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 156 16 Roussel Roussel NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 17 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 156 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 156 19 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 156 20 European European NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 21 Community Community NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 22 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 156 23 2001 2001 CD work_j7kpdr5srze47kmsl2scd6h4c4 156 24 - - SYM work_j7kpdr5srze47kmsl2scd6h4c4 156 25 01646 01646 CD work_j7kpdr5srze47kmsl2scd6h4c4 156 26 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 156 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 156 28 Fondation fondation NN work_j7kpdr5srze47kmsl2scd6h4c4 156 29 pour pour VBP work_j7kpdr5srze47kmsl2scd6h4c4 156 30 la la FW work_j7kpdr5srze47kmsl2scd6h4c4 156 31 Recherche Recherche NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 32 Médicale Médicale NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 156 34 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 156 35 Association Association NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 36 Française française CD work_j7kpdr5srze47kmsl2scd6h4c4 156 37 contre contre NN work_j7kpdr5srze47kmsl2scd6h4c4 156 38 les les NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 39 Myopathies- Myopathies- NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 40 INSERM INSERM NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 41 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 156 42 Maladies Maladies NNP work_j7kpdr5srze47kmsl2scd6h4c4 156 43 Rares Rares NNPS work_j7kpdr5srze47kmsl2scd6h4c4 156 44 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 156 45 . . . work_j7kpdr5srze47kmsl2scd6h4c4 157 1 REFERENCES reference NNS work_j7kpdr5srze47kmsl2scd6h4c4 157 2 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 157 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 158 1 Gozal Gozal NNP work_j7kpdr5srze47kmsl2scd6h4c4 158 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 158 3 D. D. NNP work_j7kpdr5srze47kmsl2scd6h4c4 158 4 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 158 5 1998 1998 CD work_j7kpdr5srze47kmsl2scd6h4c4 158 6 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 158 7 Congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 158 8 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 158 9 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 158 10 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 158 11 : : : work_j7kpdr5srze47kmsl2scd6h4c4 158 12 an an DT work_j7kpdr5srze47kmsl2scd6h4c4 158 13 update update NN work_j7kpdr5srze47kmsl2scd6h4c4 158 14 . . . work_j7kpdr5srze47kmsl2scd6h4c4 159 1 Pediatr Pediatr NNP work_j7kpdr5srze47kmsl2scd6h4c4 159 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 160 1 Pulmonol Pulmonol NNP work_j7kpdr5srze47kmsl2scd6h4c4 160 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 160 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 160 4 26 26 CD work_j7kpdr5srze47kmsl2scd6h4c4 160 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 160 6 273–282 273–282 CD work_j7kpdr5srze47kmsl2scd6h4c4 160 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 161 1 2 2 LS work_j7kpdr5srze47kmsl2scd6h4c4 161 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 162 1 Amiel Amiel NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 3 J. J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 5 Laudier Laudier NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 7 B. B. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 9 Attié-Bitach Attié-Bitach NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 11 T. T. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 13 Trang Trang NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 15 H. H. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 17 de de NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 18 Pontual Pontual NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 19 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 20 L. L. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 21 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 22 Gener Gener NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 23 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 24 B. B. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 25 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 26 Trochet Trochet NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 27 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 28 D. D. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 29 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 30 Etchevers Etchevers NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 32 H. H. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 34 Ray Ray NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 35 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 36 P. P. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 37 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 38 Simonneau Simonneau NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 39 , , , work_j7kpdr5srze47kmsl2scd6h4c4 162 40 M. M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 41 et et NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 42 al al NNP work_j7kpdr5srze47kmsl2scd6h4c4 162 43 . . . work_j7kpdr5srze47kmsl2scd6h4c4 163 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 163 2 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 163 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 163 4 Polyalanine polyalanine JJ work_j7kpdr5srze47kmsl2scd6h4c4 163 5 expansion expansion NN work_j7kpdr5srze47kmsl2scd6h4c4 163 6 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 163 7 frameshift frameshift NN work_j7kpdr5srze47kmsl2scd6h4c4 163 8 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 163 9 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 163 10 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 163 11 paired pair VBN work_j7kpdr5srze47kmsl2scd6h4c4 163 12 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 163 13 like like JJ work_j7kpdr5srze47kmsl2scd6h4c4 163 14 homeobox homeobox NN work_j7kpdr5srze47kmsl2scd6h4c4 163 15 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 163 16 PHOX2B PHOX2B NNP work_j7kpdr5srze47kmsl2scd6h4c4 163 17 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 163 18 congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 163 19 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 163 20 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 163 21 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 163 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 164 1 Nat Nat NNP work_j7kpdr5srze47kmsl2scd6h4c4 164 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 165 1 Genet Genet NNP work_j7kpdr5srze47kmsl2scd6h4c4 165 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 165 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 165 4 33 33 CD work_j7kpdr5srze47kmsl2scd6h4c4 165 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 165 6 459–461 459–461 CD work_j7kpdr5srze47kmsl2scd6h4c4 165 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 166 1 3 3 LS work_j7kpdr5srze47kmsl2scd6h4c4 166 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 167 1 Croaker Croaker NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 3 G.D. G.D. NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 5 Shi Shi NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 7 E. E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 9 Simpson Simpson NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 11 E. E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 13 Cartmill Cartmill NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 15 T. T. NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 16 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 167 17 Cass Cass NNP work_j7kpdr5srze47kmsl2scd6h4c4 167 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 167 19 D.T. D.T. NNP work_j7kpdr5srze47kmsl2scd6h4c4 168 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 168 2 1998 1998 CD work_j7kpdr5srze47kmsl2scd6h4c4 168 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 168 4 Congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 168 5 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 168 6 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 168 7 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 168 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 168 9 Hirschsprung Hirschsprung NNP work_j7kpdr5srze47kmsl2scd6h4c4 168 10 ’s ’s POS work_j7kpdr5srze47kmsl2scd6h4c4 168 11 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 168 12 . . . work_j7kpdr5srze47kmsl2scd6h4c4 169 1 Arch arch UH work_j7kpdr5srze47kmsl2scd6h4c4 169 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 170 1 Dis Dis NNP work_j7kpdr5srze47kmsl2scd6h4c4 170 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 171 1 Child child NN work_j7kpdr5srze47kmsl2scd6h4c4 171 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 171 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 171 4 78 78 CD work_j7kpdr5srze47kmsl2scd6h4c4 171 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 171 6 316–322 316–322 CD work_j7kpdr5srze47kmsl2scd6h4c4 171 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 172 1 4 4 LS work_j7kpdr5srze47kmsl2scd6h4c4 172 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 173 1 Brunet Brunet NNP work_j7kpdr5srze47kmsl2scd6h4c4 173 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 173 3 J.F. J.F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 174 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 174 2 Pattyn Pattyn NNP work_j7kpdr5srze47kmsl2scd6h4c4 174 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 174 4 A. a. NN work_j7kpdr5srze47kmsl2scd6h4c4 175 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 175 2 2002 2002 CD work_j7kpdr5srze47kmsl2scd6h4c4 175 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 175 4 Phox2 Phox2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 175 5 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 175 6 — — : work_j7kpdr5srze47kmsl2scd6h4c4 175 7 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 175 8 patterning pattern VBG work_j7kpdr5srze47kmsl2scd6h4c4 175 9 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 175 10 connectivity connectivity NN work_j7kpdr5srze47kmsl2scd6h4c4 175 11 . . . work_j7kpdr5srze47kmsl2scd6h4c4 176 1 Curr curr UH work_j7kpdr5srze47kmsl2scd6h4c4 176 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 177 1 Opin opin JJ work_j7kpdr5srze47kmsl2scd6h4c4 177 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 178 1 Genet Genet NNP work_j7kpdr5srze47kmsl2scd6h4c4 178 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 179 1 Dev Dev NNP work_j7kpdr5srze47kmsl2scd6h4c4 179 2 . . NNP work_j7kpdr5srze47kmsl2scd6h4c4 179 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 179 4 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 179 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 179 6 435–440 435–440 CD work_j7kpdr5srze47kmsl2scd6h4c4 179 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 180 1 5 5 CD work_j7kpdr5srze47kmsl2scd6h4c4 180 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 181 1 Goridis Goridis NNP work_j7kpdr5srze47kmsl2scd6h4c4 181 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 181 3 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 181 4 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 181 5 Rohrer Rohrer NNP work_j7kpdr5srze47kmsl2scd6h4c4 181 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 181 7 H. H. NNP work_j7kpdr5srze47kmsl2scd6h4c4 181 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 181 9 2002 2002 CD work_j7kpdr5srze47kmsl2scd6h4c4 181 10 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 181 11 Specification Specification NNP work_j7kpdr5srze47kmsl2scd6h4c4 181 12 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 181 13 catecholaminergic catecholaminergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 181 14 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 181 15 serotonergic serotonergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 181 16 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 181 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 182 1 Nat Nat NNP work_j7kpdr5srze47kmsl2scd6h4c4 182 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 183 1 Rev. Rev. NNP work_j7kpdr5srze47kmsl2scd6h4c4 184 1 Neurosci Neurosci NNP work_j7kpdr5srze47kmsl2scd6h4c4 184 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 184 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 184 4 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 184 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 184 6 531–541 531–541 CD work_j7kpdr5srze47kmsl2scd6h4c4 184 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 185 1 6 6 CD work_j7kpdr5srze47kmsl2scd6h4c4 185 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 186 1 Pattyn pattyn JJ work_j7kpdr5srze47kmsl2scd6h4c4 186 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 3 A. a. NN work_j7kpdr5srze47kmsl2scd6h4c4 186 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 5 Morin Morin NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 7 X. X. NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 9 Cremer Cremer NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 11 H. H. NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 13 Goridis Goridis NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 15 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 16 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 186 17 Brunet Brunet NNP work_j7kpdr5srze47kmsl2scd6h4c4 186 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 186 19 J.F. J.F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 187 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 187 2 1999 1999 CD work_j7kpdr5srze47kmsl2scd6h4c4 187 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 187 4 The the DT work_j7kpdr5srze47kmsl2scd6h4c4 187 5 homeobox homeobox NN work_j7kpdr5srze47kmsl2scd6h4c4 187 6 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 187 7 Phox2b Phox2b `` work_j7kpdr5srze47kmsl2scd6h4c4 187 8 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 187 9 essential essential JJ work_j7kpdr5srze47kmsl2scd6h4c4 187 10 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 187 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 187 12 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 187 13 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 187 14 autonomic autonomic NNP work_j7kpdr5srze47kmsl2scd6h4c4 187 15 neural neural NNP work_j7kpdr5srze47kmsl2scd6h4c4 187 16 crest crest NNP work_j7kpdr5srze47kmsl2scd6h4c4 187 17 derivatives derivative NNS work_j7kpdr5srze47kmsl2scd6h4c4 187 18 . . . work_j7kpdr5srze47kmsl2scd6h4c4 188 1 Nature nature NN work_j7kpdr5srze47kmsl2scd6h4c4 188 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 188 3 399 399 CD work_j7kpdr5srze47kmsl2scd6h4c4 188 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 188 5 366–370 366–370 CD work_j7kpdr5srze47kmsl2scd6h4c4 188 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 189 1 7 7 LS work_j7kpdr5srze47kmsl2scd6h4c4 189 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 190 1 Pattyn pattyn JJ work_j7kpdr5srze47kmsl2scd6h4c4 190 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 190 3 A. a. NN work_j7kpdr5srze47kmsl2scd6h4c4 190 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 190 5 Goridis Goridis NNP work_j7kpdr5srze47kmsl2scd6h4c4 190 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 190 7 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 190 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 190 9 Brunet Brunet NNP work_j7kpdr5srze47kmsl2scd6h4c4 190 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 190 11 J.F. J.F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 191 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 191 2 2000 2000 CD work_j7kpdr5srze47kmsl2scd6h4c4 191 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 191 4 Specification Specification NNP work_j7kpdr5srze47kmsl2scd6h4c4 191 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 191 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 191 7 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 191 8 noradrenergic noradrenergic JJ work_j7kpdr5srze47kmsl2scd6h4c4 191 9 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 191 10 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 191 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 191 12 homeobox homeobox NNP work_j7kpdr5srze47kmsl2scd6h4c4 191 13 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 191 14 Phox2b phox2b ADD work_j7kpdr5srze47kmsl2scd6h4c4 191 15 . . . work_j7kpdr5srze47kmsl2scd6h4c4 192 1 Mol Mol NNP work_j7kpdr5srze47kmsl2scd6h4c4 192 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 193 1 Cell cell NN work_j7kpdr5srze47kmsl2scd6h4c4 193 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 194 1 Neurosci Neurosci NNP work_j7kpdr5srze47kmsl2scd6h4c4 194 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 194 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 194 4 15 15 CD work_j7kpdr5srze47kmsl2scd6h4c4 194 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 194 6 235–243 235–243 CD work_j7kpdr5srze47kmsl2scd6h4c4 194 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 195 1 8 8 LS work_j7kpdr5srze47kmsl2scd6h4c4 195 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 196 1 Dauger Dauger NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 3 S. S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 5 Renolleau Renolleau NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 7 S. S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 9 Vardon Vardon NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 11 G. G. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 13 Népote Népote NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 15 V. V. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 17 Mas Mas NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 19 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 21 Simonneau Simonneau NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 22 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 23 M. M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 25 Gaultier Gaultier NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 27 C. C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 28 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 196 29 Gallego Gallego NNP work_j7kpdr5srze47kmsl2scd6h4c4 196 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 196 31 J. J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 197 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 197 2 1999 1999 CD work_j7kpdr5srze47kmsl2scd6h4c4 197 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 197 4 Ventilatory ventilatory NN work_j7kpdr5srze47kmsl2scd6h4c4 197 5 responses response NNS work_j7kpdr5srze47kmsl2scd6h4c4 197 6 to to IN work_j7kpdr5srze47kmsl2scd6h4c4 197 7 hypercapnia hypercapnia NNP work_j7kpdr5srze47kmsl2scd6h4c4 197 8 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 197 9 hypoxia hypoxia NNP work_j7kpdr5srze47kmsl2scd6h4c4 197 10 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 197 11 Mash-1 Mash-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 197 12 heterozygous heterozygous JJ work_j7kpdr5srze47kmsl2scd6h4c4 197 13 newborn newborn JJ work_j7kpdr5srze47kmsl2scd6h4c4 197 14 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 197 15 adult adult NN work_j7kpdr5srze47kmsl2scd6h4c4 197 16 mice mouse NNS work_j7kpdr5srze47kmsl2scd6h4c4 197 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 198 1 Pediatr Pediatr NNP work_j7kpdr5srze47kmsl2scd6h4c4 198 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 199 1 Res Res NNP work_j7kpdr5srze47kmsl2scd6h4c4 199 2 . . NNP work_j7kpdr5srze47kmsl2scd6h4c4 199 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 199 4 46 46 CD work_j7kpdr5srze47kmsl2scd6h4c4 199 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 199 6 535–542 535–542 CD work_j7kpdr5srze47kmsl2scd6h4c4 199 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 200 1 9 9 CD work_j7kpdr5srze47kmsl2scd6h4c4 200 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 201 1 Guillemot Guillemot NNP work_j7kpdr5srze47kmsl2scd6h4c4 201 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 201 3 F. F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 201 4 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 201 5 Joyner Joyner NNP work_j7kpdr5srze47kmsl2scd6h4c4 201 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 201 7 A.L. A.L. NNP work_j7kpdr5srze47kmsl2scd6h4c4 202 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 202 2 1993 1993 CD work_j7kpdr5srze47kmsl2scd6h4c4 202 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 202 4 Dynamic dynamic JJ work_j7kpdr5srze47kmsl2scd6h4c4 202 5 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 202 6 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 202 7 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 202 8 murine murine NN work_j7kpdr5srze47kmsl2scd6h4c4 202 9 Achaete Achaete NNP work_j7kpdr5srze47kmsl2scd6h4c4 202 10 – – : work_j7kpdr5srze47kmsl2scd6h4c4 202 11 Scute Scute NNP work_j7kpdr5srze47kmsl2scd6h4c4 202 12 homologue homologue NN work_j7kpdr5srze47kmsl2scd6h4c4 202 13 Mash-1 Mash-1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 202 14 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 202 15 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 202 16 developing develop VBG work_j7kpdr5srze47kmsl2scd6h4c4 202 17 nervous nervous JJ work_j7kpdr5srze47kmsl2scd6h4c4 202 18 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 202 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 203 1 Mech mech NN work_j7kpdr5srze47kmsl2scd6h4c4 203 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 204 1 Dev Dev NNP work_j7kpdr5srze47kmsl2scd6h4c4 204 2 . . NNP work_j7kpdr5srze47kmsl2scd6h4c4 204 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 204 4 42 42 CD work_j7kpdr5srze47kmsl2scd6h4c4 204 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 204 6 171–185 171–185 CD work_j7kpdr5srze47kmsl2scd6h4c4 204 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 205 1 10 10 CD work_j7kpdr5srze47kmsl2scd6h4c4 205 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 206 1 Guillemot Guillemot NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 3 F. F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 5 Lo Lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 7 L.C. L.C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 9 Johnson Johnson NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 11 J.E. J.E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 13 Auerbach Auerbach NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 15 A. A. NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 17 Anderson Anderson NNP work_j7kpdr5srze47kmsl2scd6h4c4 206 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 206 19 D.J. D.J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 207 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 207 2 Joyner Joyner NNP work_j7kpdr5srze47kmsl2scd6h4c4 207 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 207 4 A.L. A.L. NNP work_j7kpdr5srze47kmsl2scd6h4c4 208 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 208 2 1993 1993 CD work_j7kpdr5srze47kmsl2scd6h4c4 208 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 208 4 Mammalian mammalian JJ work_j7kpdr5srze47kmsl2scd6h4c4 208 5 achaete achaete NN work_j7kpdr5srze47kmsl2scd6h4c4 208 6 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 208 7 scute scute NN work_j7kpdr5srze47kmsl2scd6h4c4 208 8 homolog homolog NNP work_j7kpdr5srze47kmsl2scd6h4c4 208 9 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 208 10 is be VBZ work_j7kpdr5srze47kmsl2scd6h4c4 208 11 required require VBN work_j7kpdr5srze47kmsl2scd6h4c4 208 12 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 208 13 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 208 14 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 208 15 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 208 16 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 208 17 olfactory olfactory JJ work_j7kpdr5srze47kmsl2scd6h4c4 208 18 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 208 19 autonomic autonomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 208 20 neurons neuron NNS work_j7kpdr5srze47kmsl2scd6h4c4 208 21 . . . work_j7kpdr5srze47kmsl2scd6h4c4 209 1 Cell cell NN work_j7kpdr5srze47kmsl2scd6h4c4 209 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 209 3 75 75 CD work_j7kpdr5srze47kmsl2scd6h4c4 209 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 209 5 463–476 463–476 CD work_j7kpdr5srze47kmsl2scd6h4c4 209 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 210 1 11 11 CD work_j7kpdr5srze47kmsl2scd6h4c4 210 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 211 1 Lo Lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 211 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 211 3 L. L. NNP work_j7kpdr5srze47kmsl2scd6h4c4 211 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 211 5 Tiveron Tiveron NNP work_j7kpdr5srze47kmsl2scd6h4c4 211 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 211 7 M.C. M.C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 212 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 212 2 Anderson Anderson NNP work_j7kpdr5srze47kmsl2scd6h4c4 212 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 212 4 D.J. D.J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 213 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 213 2 1998 1998 CD work_j7kpdr5srze47kmsl2scd6h4c4 213 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 213 4 MASH1 MASH1 NNP work_j7kpdr5srze47kmsl2scd6h4c4 213 5 activates activate VBZ work_j7kpdr5srze47kmsl2scd6h4c4 213 6 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 213 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 213 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 213 9 paired pair VBN work_j7kpdr5srze47kmsl2scd6h4c4 213 10 homeodomain homeodomain NNP work_j7kpdr5srze47kmsl2scd6h4c4 213 11 transcription transcription NN work_j7kpdr5srze47kmsl2scd6h4c4 213 12 factor factor NN work_j7kpdr5srze47kmsl2scd6h4c4 213 13 Phox2a Phox2a NNP work_j7kpdr5srze47kmsl2scd6h4c4 213 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 213 15 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 213 16 couples couple VBZ work_j7kpdr5srze47kmsl2scd6h4c4 213 17 pan pan JJ work_j7kpdr5srze47kmsl2scd6h4c4 213 18 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 213 19 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 213 20 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 213 21 subtype subtype NN work_j7kpdr5srze47kmsl2scd6h4c4 213 22 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 213 23 specific specific JJ work_j7kpdr5srze47kmsl2scd6h4c4 213 24 components component NNS work_j7kpdr5srze47kmsl2scd6h4c4 213 25 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 213 26 autonomic autonomic JJ work_j7kpdr5srze47kmsl2scd6h4c4 213 27 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 213 28 identity identity NN work_j7kpdr5srze47kmsl2scd6h4c4 213 29 . . . work_j7kpdr5srze47kmsl2scd6h4c4 214 1 Development development NN work_j7kpdr5srze47kmsl2scd6h4c4 214 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 214 3 125 125 CD work_j7kpdr5srze47kmsl2scd6h4c4 214 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 214 5 609–620 609–620 CD work_j7kpdr5srze47kmsl2scd6h4c4 214 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 215 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 215 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 216 1 Lo Lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 216 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 216 3 L. L. NNP work_j7kpdr5srze47kmsl2scd6h4c4 216 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 216 5 Morin Morin NNP work_j7kpdr5srze47kmsl2scd6h4c4 216 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 216 7 X. X. NNP work_j7kpdr5srze47kmsl2scd6h4c4 216 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 216 9 Brunet Brunet NNP work_j7kpdr5srze47kmsl2scd6h4c4 216 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 216 11 J.F. J.F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 217 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 217 2 Anderson Anderson NNP work_j7kpdr5srze47kmsl2scd6h4c4 217 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 217 4 D.J. D.J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 218 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 218 2 1999 1999 CD work_j7kpdr5srze47kmsl2scd6h4c4 218 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 218 4 Specification specification NN work_j7kpdr5srze47kmsl2scd6h4c4 218 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 218 6 neurotransmitter neurotransmitter NN work_j7kpdr5srze47kmsl2scd6h4c4 218 7 identity identity NN work_j7kpdr5srze47kmsl2scd6h4c4 218 8 by by IN work_j7kpdr5srze47kmsl2scd6h4c4 218 9 Phox2 phox2 JJ work_j7kpdr5srze47kmsl2scd6h4c4 218 10 proteins protein NNS work_j7kpdr5srze47kmsl2scd6h4c4 218 11 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 218 12 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 218 13 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 218 14 stem stem NN work_j7kpdr5srze47kmsl2scd6h4c4 218 15 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 218 16 . . . work_j7kpdr5srze47kmsl2scd6h4c4 219 1 Neuron Neuron NNP work_j7kpdr5srze47kmsl2scd6h4c4 219 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 219 3 22 22 CD work_j7kpdr5srze47kmsl2scd6h4c4 219 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 219 5 693–705 693–705 CD work_j7kpdr5srze47kmsl2scd6h4c4 219 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 220 1 13 13 CD work_j7kpdr5srze47kmsl2scd6h4c4 220 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 221 1 Bertrand Bertrand NNP work_j7kpdr5srze47kmsl2scd6h4c4 221 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 221 3 N. N. NNP work_j7kpdr5srze47kmsl2scd6h4c4 221 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 221 5 Castro Castro NNP work_j7kpdr5srze47kmsl2scd6h4c4 221 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 221 7 D.S. D.S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 222 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 222 2 Guillemot Guillemot NNP work_j7kpdr5srze47kmsl2scd6h4c4 222 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 222 4 F. F. NNP work_j7kpdr5srze47kmsl2scd6h4c4 222 5 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 222 6 2002 2002 CD work_j7kpdr5srze47kmsl2scd6h4c4 222 7 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 222 8 Proneural proneural JJ work_j7kpdr5srze47kmsl2scd6h4c4 222 9 genes gene NNS work_j7kpdr5srze47kmsl2scd6h4c4 222 10 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 222 11 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 222 12 specification specification NN work_j7kpdr5srze47kmsl2scd6h4c4 222 13 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 222 14 neural neural JJ work_j7kpdr5srze47kmsl2scd6h4c4 222 15 cell cell NN work_j7kpdr5srze47kmsl2scd6h4c4 222 16 types type NNS work_j7kpdr5srze47kmsl2scd6h4c4 222 17 . . . work_j7kpdr5srze47kmsl2scd6h4c4 223 1 Nat Nat NNP work_j7kpdr5srze47kmsl2scd6h4c4 223 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 224 1 Rev. Rev. NNP work_j7kpdr5srze47kmsl2scd6h4c4 225 1 Neurosci Neurosci NNP work_j7kpdr5srze47kmsl2scd6h4c4 225 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 225 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 225 4 3 3 CD work_j7kpdr5srze47kmsl2scd6h4c4 225 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 225 6 517–530 517–530 CD work_j7kpdr5srze47kmsl2scd6h4c4 225 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 226 1 14 14 CD work_j7kpdr5srze47kmsl2scd6h4c4 226 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 227 1 Puffenberger Puffenberger NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 3 E.G. E.G. NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 5 Hosoda Hosoda NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 7 K. K. NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 9 Washington Washington NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 11 S. S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 13 Nakao Nakao NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 15 K. K. NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 17 deWit deWit NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 19 D. D. NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 21 Yanagisawa Yanagisawa NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 22 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 23 M. M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 24 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 227 25 Chakravart Chakravart NNP work_j7kpdr5srze47kmsl2scd6h4c4 227 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 227 27 A. a. NN work_j7kpdr5srze47kmsl2scd6h4c4 228 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 228 2 1994 1994 LS work_j7kpdr5srze47kmsl2scd6h4c4 228 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 228 4 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 228 5 missense missense NN work_j7kpdr5srze47kmsl2scd6h4c4 228 6 mutation mutation NN work_j7kpdr5srze47kmsl2scd6h4c4 228 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 228 8 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 228 9 endothelin endothelin NNP work_j7kpdr5srze47kmsl2scd6h4c4 228 10 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 228 11 B B NNP work_j7kpdr5srze47kmsl2scd6h4c4 228 12 receptor receptor NN work_j7kpdr5srze47kmsl2scd6h4c4 228 13 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 228 14 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 228 15 multigenic multigenic JJ work_j7kpdr5srze47kmsl2scd6h4c4 228 16 Hirschsprung Hirschsprung NNP work_j7kpdr5srze47kmsl2scd6h4c4 228 17 ’s ’s POS work_j7kpdr5srze47kmsl2scd6h4c4 228 18 disease disease NN work_j7kpdr5srze47kmsl2scd6h4c4 228 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 229 1 Cell cell NN work_j7kpdr5srze47kmsl2scd6h4c4 229 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 229 3 79 79 CD work_j7kpdr5srze47kmsl2scd6h4c4 229 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 229 5 1257–1266 1257–1266 CD work_j7kpdr5srze47kmsl2scd6h4c4 229 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 230 1 15 15 CD work_j7kpdr5srze47kmsl2scd6h4c4 230 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 231 1 Goodman Goodman NNP work_j7kpdr5srze47kmsl2scd6h4c4 231 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 231 3 F.R. F.R. NNP work_j7kpdr5srze47kmsl2scd6h4c4 232 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 232 2 Scambler Scambler NNP work_j7kpdr5srze47kmsl2scd6h4c4 232 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 232 4 P.J. P.J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 233 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 233 2 2001 2001 CD work_j7kpdr5srze47kmsl2scd6h4c4 233 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 233 4 Human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 233 5 HOX HOX NNP work_j7kpdr5srze47kmsl2scd6h4c4 233 6 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 233 7 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 233 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 234 1 Clin Clin NNP work_j7kpdr5srze47kmsl2scd6h4c4 234 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 235 1 Genet Genet NNP work_j7kpdr5srze47kmsl2scd6h4c4 235 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 235 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 235 4 59 59 CD work_j7kpdr5srze47kmsl2scd6h4c4 235 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 235 6 1–11 1–11 CD work_j7kpdr5srze47kmsl2scd6h4c4 235 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 236 1 16 16 CD work_j7kpdr5srze47kmsl2scd6h4c4 236 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 237 1 Stromme Stromme NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 3 P. P. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 5 Mangelsdorf Mangelsdorf NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 7 M.E. M.E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 9 Shaw Shaw NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 11 M.A. M.A. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 13 Lower Lower NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 15 K.M. K.M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 17 Lewis Lewis NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 19 S.M. S.M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 21 Bruyere Bruyere NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 22 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 23 H. H. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 25 Lutcherath Lutcherath NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 27 V. V. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 28 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 29 Gedeon Gedeon NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 30 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 31 A.K. A.K. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 32 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 33 Wallace Wallace NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 34 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 35 R.H. R.H. NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 36 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 37 Scheffer Scheffer NNP work_j7kpdr5srze47kmsl2scd6h4c4 237 38 , , , work_j7kpdr5srze47kmsl2scd6h4c4 237 39 I.E. I.E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 238 1 et et NNP work_j7kpdr5srze47kmsl2scd6h4c4 238 2 al al NNP work_j7kpdr5srze47kmsl2scd6h4c4 238 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 239 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 239 2 2002 2002 CD work_j7kpdr5srze47kmsl2scd6h4c4 239 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 239 4 Mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 239 5 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 239 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 239 7 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 239 8 ortholog ortholog NN work_j7kpdr5srze47kmsl2scd6h4c4 239 9 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 239 10 Aristaless Aristaless NNP work_j7kpdr5srze47kmsl2scd6h4c4 239 11 cause cause NN work_j7kpdr5srze47kmsl2scd6h4c4 239 12 X X NNS work_j7kpdr5srze47kmsl2scd6h4c4 239 13 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 239 14 linked link VBN work_j7kpdr5srze47kmsl2scd6h4c4 239 15 mental mental JJ work_j7kpdr5srze47kmsl2scd6h4c4 239 16 retardation retardation NN work_j7kpdr5srze47kmsl2scd6h4c4 239 17 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 239 18 epilepsy epilepsy NN work_j7kpdr5srze47kmsl2scd6h4c4 239 19 . . . work_j7kpdr5srze47kmsl2scd6h4c4 240 1 Nat Nat NNP work_j7kpdr5srze47kmsl2scd6h4c4 240 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 241 1 Genet Genet NNP work_j7kpdr5srze47kmsl2scd6h4c4 241 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 241 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 241 4 30 30 CD work_j7kpdr5srze47kmsl2scd6h4c4 241 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 241 6 441–445 441–445 CD work_j7kpdr5srze47kmsl2scd6h4c4 241 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 242 1 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 242 2 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 242 3 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 242 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 242 5 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 242 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 242 7 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 242 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 243 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 243 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 243 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 243 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 244 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 2 3179 3179 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 3 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 244 4 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 244 5 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 244 6 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 244 7 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 244 8 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 244 9 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 244 10 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 11 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 12 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 13 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 244 14 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 244 15 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 244 16 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 244 17 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 244 18 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 244 19 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 244 20 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 244 21 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 244 22 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 23 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 24 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 25 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 26 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 27 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 28 - - : work_j7kpdr5srze47kmsl2scd6h4c4 244 29 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 244 30 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 244 31 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 32 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 244 33 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 34 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 35 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 244 36 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 244 37 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 244 38 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 39 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 40 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 41 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 42 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 43 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 44 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 244 45 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 244 46 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 47 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 244 48 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 49 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 50 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 51 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 52 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 53 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 54 , , , work_j7kpdr5srze47kmsl2scd6h4c4 244 55 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 56 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 57 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 58 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 59 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 244 60 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 244 61 : : : work_j7kpdr5srze47kmsl2scd6h4c4 244 62 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 63 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 64 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 65 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 244 66 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 67 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 68 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 69 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 70 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 244 71 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 244 72 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 244 73 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 74 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 75 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 76 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 77 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 244 78 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 79 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 244 80 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 81 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 82 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 83 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 84 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 85 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org NNP work_j7kpdr5srze47kmsl2scd6h4c4 244 86 17 17 CD work_j7kpdr5srze47kmsl2scd6h4c4 244 87 . . . work_j7kpdr5srze47kmsl2scd6h4c4 245 1 Weese Weese NNP work_j7kpdr5srze47kmsl2scd6h4c4 245 2 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 245 3 Mayer Mayer NNP work_j7kpdr5srze47kmsl2scd6h4c4 245 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 245 5 D.E. D.E. NNP work_j7kpdr5srze47kmsl2scd6h4c4 245 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 245 7 Shannon Shannon NNP work_j7kpdr5srze47kmsl2scd6h4c4 245 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 245 9 D.C. D.C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 245 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 245 11 Keens Keens NNP work_j7kpdr5srze47kmsl2scd6h4c4 245 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 245 13 T.G. T.G. NNP work_j7kpdr5srze47kmsl2scd6h4c4 246 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 246 2 Silvestri Silvestri NNP work_j7kpdr5srze47kmsl2scd6h4c4 246 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 246 4 J.M. J.M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 247 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 247 2 1999 1999 CD work_j7kpdr5srze47kmsl2scd6h4c4 247 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 247 4 Idiopathic idiopathic JJ work_j7kpdr5srze47kmsl2scd6h4c4 247 5 congenital congenital JJ work_j7kpdr5srze47kmsl2scd6h4c4 247 6 central central JJ work_j7kpdr5srze47kmsl2scd6h4c4 247 7 hypoventilation hypoventilation NN work_j7kpdr5srze47kmsl2scd6h4c4 247 8 syndrome syndrome NN work_j7kpdr5srze47kmsl2scd6h4c4 247 9 : : : work_j7kpdr5srze47kmsl2scd6h4c4 247 10 diagnosis diagnosis NN work_j7kpdr5srze47kmsl2scd6h4c4 247 11 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 247 12 management management NN work_j7kpdr5srze47kmsl2scd6h4c4 247 13 . . . work_j7kpdr5srze47kmsl2scd6h4c4 248 1 Am Am NNP work_j7kpdr5srze47kmsl2scd6h4c4 248 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 249 1 J. J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 249 2 Respir Respir NNP work_j7kpdr5srze47kmsl2scd6h4c4 249 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 250 1 Crit Crit NNP work_j7kpdr5srze47kmsl2scd6h4c4 250 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 251 1 Care care VB work_j7kpdr5srze47kmsl2scd6h4c4 251 2 Med Med NNP work_j7kpdr5srze47kmsl2scd6h4c4 251 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 251 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 251 5 160 160 CD work_j7kpdr5srze47kmsl2scd6h4c4 251 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 251 7 368–73 368–73 CD work_j7kpdr5srze47kmsl2scd6h4c4 251 8 . . . work_j7kpdr5srze47kmsl2scd6h4c4 252 1 18 18 CD work_j7kpdr5srze47kmsl2scd6h4c4 252 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 253 1 Odent Odent NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 3 S. S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 5 Attié-Bitach Attié-Bitach NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 7 T. T. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 9 Blayau Blayau NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 10 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 11 M. M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 12 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 13 Mathieu Mathieu NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 14 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 15 M. M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 16 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 17 Augé,J. Augé,J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 18 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 19 Delezoide Delezoide NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 20 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 21 A.L. A.L. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 22 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 23 Gall Gall NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 24 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 25 J.Y. J.Y. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 26 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 27 Le Le NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 28 Marec Marec NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 29 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 30 B. B. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 31 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 32 Munnich Munnich NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 33 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 34 A. A. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 35 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 36 David David NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 37 , , , work_j7kpdr5srze47kmsl2scd6h4c4 253 38 V. V. NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 39 et et NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 40 al al NNP work_j7kpdr5srze47kmsl2scd6h4c4 253 41 . . . work_j7kpdr5srze47kmsl2scd6h4c4 254 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 254 2 1999 1999 CD work_j7kpdr5srze47kmsl2scd6h4c4 254 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 254 4 Expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 254 5 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 254 6 the the DT work_j7kpdr5srze47kmsl2scd6h4c4 254 7 Sonic Sonic NNP work_j7kpdr5srze47kmsl2scd6h4c4 254 8 Hedgehog Hedgehog NNP work_j7kpdr5srze47kmsl2scd6h4c4 254 9 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 254 10 SHH SHH NNP work_j7kpdr5srze47kmsl2scd6h4c4 254 11 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 254 12 gene gene NN work_j7kpdr5srze47kmsl2scd6h4c4 254 13 during during IN work_j7kpdr5srze47kmsl2scd6h4c4 254 14 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 254 15 human human JJ work_j7kpdr5srze47kmsl2scd6h4c4 254 16 development development NN work_j7kpdr5srze47kmsl2scd6h4c4 254 17 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 254 18 phenotypic phenotypic JJ work_j7kpdr5srze47kmsl2scd6h4c4 254 19 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 254 20 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 254 21 new new JJ work_j7kpdr5srze47kmsl2scd6h4c4 254 22 mutations mutation NNS work_j7kpdr5srze47kmsl2scd6h4c4 254 23 causing cause VBG work_j7kpdr5srze47kmsl2scd6h4c4 254 24 holoprosencephaly holoprosencephaly NNP work_j7kpdr5srze47kmsl2scd6h4c4 254 25 . . . work_j7kpdr5srze47kmsl2scd6h4c4 255 1 Hum hum UH work_j7kpdr5srze47kmsl2scd6h4c4 255 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 256 1 Mol Mol NNP work_j7kpdr5srze47kmsl2scd6h4c4 256 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 257 1 Genet Genet NNP work_j7kpdr5srze47kmsl2scd6h4c4 257 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 257 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 257 4 8 8 CD work_j7kpdr5srze47kmsl2scd6h4c4 257 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 257 6 1683–1689 1683–1689 CD work_j7kpdr5srze47kmsl2scd6h4c4 257 7 . . . work_j7kpdr5srze47kmsl2scd6h4c4 258 1 19 19 CD work_j7kpdr5srze47kmsl2scd6h4c4 258 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 259 1 He -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 259 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 3 T.C. T.C. NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 5 Zhou Zhou NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 7 S. S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 8 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 9 da da NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 10 Costa Costa NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 11 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 12 L.T. L.T. NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 13 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 14 Yu Yu NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 15 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 16 J. J. NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 17 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 18 Kinzler Kinzler NNP work_j7kpdr5srze47kmsl2scd6h4c4 259 19 , , , work_j7kpdr5srze47kmsl2scd6h4c4 259 20 K.W. K.W. NNP work_j7kpdr5srze47kmsl2scd6h4c4 260 1 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 260 2 Vogelstein Vogelstein NNP work_j7kpdr5srze47kmsl2scd6h4c4 260 3 , , , work_j7kpdr5srze47kmsl2scd6h4c4 260 4 B. B. NNP work_j7kpdr5srze47kmsl2scd6h4c4 261 1 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 261 2 1998 1998 LS work_j7kpdr5srze47kmsl2scd6h4c4 261 3 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 261 4 A a DT work_j7kpdr5srze47kmsl2scd6h4c4 261 5 simplified simplified JJ work_j7kpdr5srze47kmsl2scd6h4c4 261 6 system system NN work_j7kpdr5srze47kmsl2scd6h4c4 261 7 for for IN work_j7kpdr5srze47kmsl2scd6h4c4 261 8 generating generate VBG work_j7kpdr5srze47kmsl2scd6h4c4 261 9 recombinant recombinant JJ work_j7kpdr5srze47kmsl2scd6h4c4 261 10 adenoviruses adenovirus NNS work_j7kpdr5srze47kmsl2scd6h4c4 261 11 . . . work_j7kpdr5srze47kmsl2scd6h4c4 262 1 Proc Proc NNP work_j7kpdr5srze47kmsl2scd6h4c4 262 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 263 1 Natl Natl NNP work_j7kpdr5srze47kmsl2scd6h4c4 263 2 Acad Acad NNP work_j7kpdr5srze47kmsl2scd6h4c4 263 3 . . . work_j7kpdr5srze47kmsl2scd6h4c4 264 1 Sci Sci NNP work_j7kpdr5srze47kmsl2scd6h4c4 264 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 265 1 USA USA NNP work_j7kpdr5srze47kmsl2scd6h4c4 265 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 265 3 95 95 CD work_j7kpdr5srze47kmsl2scd6h4c4 265 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 265 5 2509–2514 2509–2514 CD work_j7kpdr5srze47kmsl2scd6h4c4 265 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 266 1 20 20 CD work_j7kpdr5srze47kmsl2scd6h4c4 266 2 . . . work_j7kpdr5srze47kmsl2scd6h4c4 267 1 Boisseau Boisseau NNP work_j7kpdr5srze47kmsl2scd6h4c4 267 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 267 3 S. S. NNP work_j7kpdr5srze47kmsl2scd6h4c4 267 4 and and CC work_j7kpdr5srze47kmsl2scd6h4c4 267 5 Simonneau Simonneau NNP work_j7kpdr5srze47kmsl2scd6h4c4 267 6 , , , work_j7kpdr5srze47kmsl2scd6h4c4 267 7 M. M. NNP work_j7kpdr5srze47kmsl2scd6h4c4 267 8 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 267 9 1989 1989 CD work_j7kpdr5srze47kmsl2scd6h4c4 267 10 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 267 11 . . . work_j7kpdr5srze47kmsl2scd6h4c4 268 1 Mammalian mammalian JJ work_j7kpdr5srze47kmsl2scd6h4c4 268 2 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 268 3 differentiation differentiation NN work_j7kpdr5srze47kmsl2scd6h4c4 268 4 : : : work_j7kpdr5srze47kmsl2scd6h4c4 268 5 early early JJ work_j7kpdr5srze47kmsl2scd6h4c4 268 6 expression expression NN work_j7kpdr5srze47kmsl2scd6h4c4 268 7 of of IN work_j7kpdr5srze47kmsl2scd6h4c4 268 8 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 268 9 neuronal neuronal JJ work_j7kpdr5srze47kmsl2scd6h4c4 268 10 phenotype phenotype NN work_j7kpdr5srze47kmsl2scd6h4c4 268 11 from from IN work_j7kpdr5srze47kmsl2scd6h4c4 268 12 mouse mouse NN work_j7kpdr5srze47kmsl2scd6h4c4 268 13 neural neural NNP work_j7kpdr5srze47kmsl2scd6h4c4 268 14 crest crest NN work_j7kpdr5srze47kmsl2scd6h4c4 268 15 cells cell NNS work_j7kpdr5srze47kmsl2scd6h4c4 268 16 in in IN work_j7kpdr5srze47kmsl2scd6h4c4 268 17 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 268 18 chemically chemically RB work_j7kpdr5srze47kmsl2scd6h4c4 268 19 defined define VBN work_j7kpdr5srze47kmsl2scd6h4c4 268 20 cultured cultured IN work_j7kpdr5srze47kmsl2scd6h4c4 268 21 medium medium NN work_j7kpdr5srze47kmsl2scd6h4c4 268 22 . . . work_j7kpdr5srze47kmsl2scd6h4c4 269 1 Development development NN work_j7kpdr5srze47kmsl2scd6h4c4 269 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 269 3 106 106 CD work_j7kpdr5srze47kmsl2scd6h4c4 269 4 , , , work_j7kpdr5srze47kmsl2scd6h4c4 269 5 665–674 665–674 CD work_j7kpdr5srze47kmsl2scd6h4c4 269 6 . . . work_j7kpdr5srze47kmsl2scd6h4c4 270 1 3180 3180 CD work_j7kpdr5srze47kmsl2scd6h4c4 270 2 Human Human NNP work_j7kpdr5srze47kmsl2scd6h4c4 270 3 Molecular Molecular NNP work_j7kpdr5srze47kmsl2scd6h4c4 270 4 Genetics Genetics NNPS work_j7kpdr5srze47kmsl2scd6h4c4 270 5 , , , work_j7kpdr5srze47kmsl2scd6h4c4 270 6 2003 2003 CD work_j7kpdr5srze47kmsl2scd6h4c4 270 7 , , , work_j7kpdr5srze47kmsl2scd6h4c4 270 8 Vol Vol NNP work_j7kpdr5srze47kmsl2scd6h4c4 270 9 . . . work_j7kpdr5srze47kmsl2scd6h4c4 271 1 12 12 CD work_j7kpdr5srze47kmsl2scd6h4c4 271 2 , , , work_j7kpdr5srze47kmsl2scd6h4c4 271 3 No no UH work_j7kpdr5srze47kmsl2scd6h4c4 271 4 . . . work_j7kpdr5srze47kmsl2scd6h4c4 272 1 23 23 CD work_j7kpdr5srze47kmsl2scd6h4c4 272 2 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 272 3 t t NN work_j7kpdr5srze47kmsl2scd6h4c4 272 4 U u NN work_j7kpdr5srze47kmsl2scd6h4c4 272 5 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 272 6 i -PRON- PRP work_j7kpdr5srze47kmsl2scd6h4c4 272 7 ve have VB work_j7kpdr5srze47kmsl2scd6h4c4 272 8 rsite rsite NN work_j7kpdr5srze47kmsl2scd6h4c4 272 9 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 10 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 11 M M NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 12 o o NN work_j7kpdr5srze47kmsl2scd6h4c4 272 13 n n CC work_j7kpdr5srze47kmsl2scd6h4c4 272 14 tre tre NN work_j7kpdr5srze47kmsl2scd6h4c4 272 15 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 272 16 l l NN work_j7kpdr5srze47kmsl2scd6h4c4 272 17 - - HYPH work_j7kpdr5srze47kmsl2scd6h4c4 272 18 B b NN work_j7kpdr5srze47kmsl2scd6h4c4 272 19 ib ib NN work_j7kpdr5srze47kmsl2scd6h4c4 272 20 lio lio VBD work_j7kpdr5srze47kmsl2scd6h4c4 272 21 th th NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 22 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 23 q q NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 24 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 25 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 26 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 27 - - : work_j7kpdr5srze47kmsl2scd6h4c4 272 28 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 272 29 cq cq NN work_j7kpdr5srze47kmsl2scd6h4c4 272 30 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 31 isitio isitio NNS work_j7kpdr5srze47kmsl2scd6h4c4 272 32 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 33 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 34 ( ( -LRB- work_j7kpdr5srze47kmsl2scd6h4c4 272 35 P p NN work_j7kpdr5srze47kmsl2scd6h4c4 272 36 e e NN work_j7kpdr5srze47kmsl2scd6h4c4 272 37 rio rio NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 38 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 39 iq iq NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 40 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 41 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 42 s s NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 43 ) ) -RRB- work_j7kpdr5srze47kmsl2scd6h4c4 272 44 o o XX work_j7kpdr5srze47kmsl2scd6h4c4 272 45 n n NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 46 A a NN work_j7kpdr5srze47kmsl2scd6h4c4 272 47 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 48 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 49 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 50 st st NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 51 2 2 NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 52 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 272 53 , , , work_j7kpdr5srze47kmsl2scd6h4c4 272 54 2 2 CD work_j7kpdr5srze47kmsl2scd6h4c4 272 55 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 272 56 1 1 CD work_j7kpdr5srze47kmsl2scd6h4c4 272 57 0 0 CD work_j7kpdr5srze47kmsl2scd6h4c4 272 58 h h NN work_j7kpdr5srze47kmsl2scd6h4c4 272 59 ttp ttp NN work_j7kpdr5srze47kmsl2scd6h4c4 272 60 : : : work_j7kpdr5srze47kmsl2scd6h4c4 272 61 //h //h NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 62 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 63 g g NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 64 .o .o . work_j7kpdr5srze47kmsl2scd6h4c4 272 65 xfo xfo NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 66 rd rd NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 67 jo jo NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 68 u u NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 69 rn rn VBD work_j7kpdr5srze47kmsl2scd6h4c4 272 70 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 272 71 ls.o ls.o NN work_j7kpdr5srze47kmsl2scd6h4c4 272 72 rg rg NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 73 D D NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 74 o o NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 75 w w NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 76 n n XX work_j7kpdr5srze47kmsl2scd6h4c4 272 77 lo lo NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 78 a a DT work_j7kpdr5srze47kmsl2scd6h4c4 272 79 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 80 e e NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 81 d d NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 82 fro fro NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 83 m m NNP work_j7kpdr5srze47kmsl2scd6h4c4 272 84 http://hmg.oxfordjournals.org http://hmg.oxfordjournals.org ADD