id sid tid token lemma pos work_wtnfwgpzqnfabpwucygbl35wyq 1 1 untitled untitled JJ work_wtnfwgpzqnfabpwucygbl35wyq 1 2 ORIGINAL ORIGINAL NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 3 ARTICLE article NN work_wtnfwgpzqnfabpwucygbl35wyq 1 4 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 1 5 truncating truncating JJ work_wtnfwgpzqnfabpwucygbl35wyq 1 6 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 1 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 1 8 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 9 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 1 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 1 11 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 1 12 cause cause NN work_wtnfwgpzqnfabpwucygbl35wyq 1 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 1 14 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 1 16 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 1 17 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 1 18 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 1 19 affecting affect VBG work_wtnfwgpzqnfabpwucygbl35wyq 1 20 neuronal neuronal JJ work_wtnfwgpzqnfabpwucygbl35wyq 1 21 mitosis mitosis NN work_wtnfwgpzqnfabpwucygbl35wyq 1 22 Patrick Patrick NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 23 Frosk,1,2 Frosk,1,2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 24 Heleen Heleen NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 25 H h NN work_wtnfwgpzqnfabpwucygbl35wyq 1 26 Arts,3,4 arts,3,4 NN work_wtnfwgpzqnfabpwucygbl35wyq 1 27 Julien Julien NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 28 Philippe,5 Philippe,5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 29 Carter Carter NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 30 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 31 Gunn,5 Gunn,5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 32 Emma Emma NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 33 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 34 Brown,3 Brown,3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 35 Bernard Bernard NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 36 Chodirker,1,2 Chodirker,1,2 : work_wtnfwgpzqnfabpwucygbl35wyq 1 37 Louise Louise NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 38 Simard,2 Simard,2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 39 Jacek Jacek NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 40 Majewski,6 Majewski,6 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 41 Somayyeh Somayyeh NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 42 Fahiminiya,6 Fahiminiya,6 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 43 Chad Chad NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 44 Russell,5 Russell,5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 45 Yangfan Yangfan NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 46 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 47 Liu,5 Liu,5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 48 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 49 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 50 Consortium Consortium NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 51 Canadian Canadian NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 52 Rare Rare NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 53 Diseases Diseases NNPS work_wtnfwgpzqnfabpwucygbl35wyq 1 54 : : : work_wtnfwgpzqnfabpwucygbl35wyq 1 55 Models Models NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 56 & & CC work_wtnfwgpzqnfabpwucygbl35wyq 1 57 Mechanisms Mechanisms NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 58 Network Network NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 59 , , , work_wtnfwgpzqnfabpwucygbl35wyq 1 60 Robert Robert NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 61 Hegele,3,7 Hegele,3,7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 62 Nicholas Nicholas NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 63 Katsanis,5 Katsanis,5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 64 Conrad Conrad NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 65 Goerz,8 Goerz,8 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 66 Marc Marc NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 67 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 68 Del Del NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 69 Bigio,8,9 Bigio,8,9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 70 Erica Erica NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 71 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 72 Davis5 Davis5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 73 ABSTRACT ABSTRACT NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 74 Background Background NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 75 Hydranencephaly Hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 1 76 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 1 77 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 1 78 congenital congenital NN work_wtnfwgpzqnfabpwucygbl35wyq 1 79 anomaly anomaly IN work_wtnfwgpzqnfabpwucygbl35wyq 1 80 leading lead VBG work_wtnfwgpzqnfabpwucygbl35wyq 1 81 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 1 82 replacement replacement NN work_wtnfwgpzqnfabpwucygbl35wyq 1 83 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 1 84 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 1 85 cerebral cerebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 1 86 hemispheres hemisphere NNS work_wtnfwgpzqnfabpwucygbl35wyq 1 87 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 1 88 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 1 89 fluid fluid NN work_wtnfwgpzqnfabpwucygbl35wyq 1 90 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 1 91 filled fill VBN work_wtnfwgpzqnfabpwucygbl35wyq 1 92 cyst cyst NN work_wtnfwgpzqnfabpwucygbl35wyq 1 93 . . . work_wtnfwgpzqnfabpwucygbl35wyq 2 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 2 2 goals goal NNS work_wtnfwgpzqnfabpwucygbl35wyq 2 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 2 4 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 2 5 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 2 6 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 2 7 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 2 8 describe describe VB work_wtnfwgpzqnfabpwucygbl35wyq 2 9 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 2 10 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 11 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 2 13 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 14 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 2 15 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 2 16 includes include VBZ work_wtnfwgpzqnfabpwucygbl35wyq 2 17 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 2 18 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 2 19 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 20 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 2 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 2 22 anhydramnios anhydramnio NNS work_wtnfwgpzqnfabpwucygbl35wyq 2 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 2 24 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 25 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 2 26 , , , work_wtnfwgpzqnfabpwucygbl35wyq 2 27 cerebellar cerebellar NNP work_wtnfwgpzqnfabpwucygbl35wyq 2 28 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 2 29 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 2 30 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 2 31 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 2 32 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 2 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 2 34 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 2 35 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 2 36 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 2 37 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 2 38 its -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 2 39 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 40 cause cause NN work_wtnfwgpzqnfabpwucygbl35wyq 2 41 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 2 42 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 2 43 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 2 44 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 2 45 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 2 46 provide provide VB work_wtnfwgpzqnfabpwucygbl35wyq 2 47 functional functional JJ work_wtnfwgpzqnfabpwucygbl35wyq 2 48 insight insight NN work_wtnfwgpzqnfabpwucygbl35wyq 2 49 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 2 50 pathomechanism pathomechanism NN work_wtnfwgpzqnfabpwucygbl35wyq 2 51 . . . work_wtnfwgpzqnfabpwucygbl35wyq 3 1 Methods method NNS work_wtnfwgpzqnfabpwucygbl35wyq 3 2 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 3 3 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 3 4 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 3 5 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 3 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 3 7 exome exome NN work_wtnfwgpzqnfabpwucygbl35wyq 3 8 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 3 9 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 3 10 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 3 11 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 3 12 mutations mutation NNS work_wtnfwgpzqnfabpwucygbl35wyq 3 13 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 3 14 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 3 15 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 3 16 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 3 17 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 3 18 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 3 19 affected affected JJ work_wtnfwgpzqnfabpwucygbl35wyq 3 20 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 3 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 4 1 Immunohistochemistry Immunohistochemistry NNP work_wtnfwgpzqnfabpwucygbl35wyq 4 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 4 3 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 4 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 4 5 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 4 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 4 7 imaging image VBG work_wtnfwgpzqnfabpwucygbl35wyq 4 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 4 9 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 4 10 lines line NNS work_wtnfwgpzqnfabpwucygbl35wyq 4 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 4 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 4 13 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 4 14 models model NNS work_wtnfwgpzqnfabpwucygbl35wyq 4 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 4 16 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 4 17 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 4 18 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 4 19 explore explore VB work_wtnfwgpzqnfabpwucygbl35wyq 4 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 4 21 function function NN work_wtnfwgpzqnfabpwucygbl35wyq 4 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 4 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 4 24 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 4 25 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 4 26 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 4 27 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 4 28 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 4 29 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 4 30 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 4 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 5 1 Results result NNS work_wtnfwgpzqnfabpwucygbl35wyq 5 2 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 5 3 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 5 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 5 5 homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 5 6 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 5 7 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 5 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 5 9 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 5 10 segregating segregate VBG work_wtnfwgpzqnfabpwucygbl35wyq 5 11 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 5 12 MARCH MARCH NNS work_wtnfwgpzqnfabpwucygbl35wyq 5 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 6 1 Testing test VBG work_wtnfwgpzqnfabpwucygbl35wyq 6 2 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 6 3 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 6 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 6 5 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 6 6 allele allele NNP work_wtnfwgpzqnfabpwucygbl35wyq 6 7 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 6 8 patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 6 9 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 6 10 derived derive VBN work_wtnfwgpzqnfabpwucygbl35wyq 6 11 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 6 12 indicated indicate VBD work_wtnfwgpzqnfabpwucygbl35wyq 6 13 both both CC work_wtnfwgpzqnfabpwucygbl35wyq 6 14 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 6 15 reduction reduction NN work_wtnfwgpzqnfabpwucygbl35wyq 6 16 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 6 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 6 18 overall overall JJ work_wtnfwgpzqnfabpwucygbl35wyq 6 19 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 6 20 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 6 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 6 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 6 23 production production NN work_wtnfwgpzqnfabpwucygbl35wyq 6 24 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 6 25 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 6 26 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 6 27 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 6 28 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 6 29 gives give VBZ work_wtnfwgpzqnfabpwucygbl35wyq 6 30 rise rise NN work_wtnfwgpzqnfabpwucygbl35wyq 6 31 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 6 32 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 6 33 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 6 34 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 6 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 7 1 Suppression suppression NN work_wtnfwgpzqnfabpwucygbl35wyq 7 2 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 7 3 ablation ablation NN work_wtnfwgpzqnfabpwucygbl35wyq 7 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 7 5 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 7 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 7 7 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 7 8 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 7 9 recapitulated recapitulate VBN work_wtnfwgpzqnfabpwucygbl35wyq 7 10 key key JJ work_wtnfwgpzqnfabpwucygbl35wyq 7 11 features feature NNS work_wtnfwgpzqnfabpwucygbl35wyq 7 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 7 13 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 7 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 7 15 most most RBS work_wtnfwgpzqnfabpwucygbl35wyq 7 16 notably notably RB work_wtnfwgpzqnfabpwucygbl35wyq 7 17 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 7 18 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 7 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 7 20 cerebellar cerebellar NNP work_wtnfwgpzqnfabpwucygbl35wyq 7 21 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 7 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 7 23 craniofacial craniofacial JJ work_wtnfwgpzqnfabpwucygbl35wyq 7 24 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 7 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 8 1 These these DT work_wtnfwgpzqnfabpwucygbl35wyq 8 2 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 8 3 could could MD work_wtnfwgpzqnfabpwucygbl35wyq 8 4 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 8 5 rescued rescue VBN work_wtnfwgpzqnfabpwucygbl35wyq 8 6 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 8 7 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 8 8 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 8 9 length length NN work_wtnfwgpzqnfabpwucygbl35wyq 8 10 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 8 11 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 8 12 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 8 13 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 8 14 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 8 15 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 8 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 9 1 Finally finally RB work_wtnfwgpzqnfabpwucygbl35wyq 9 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 9 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 9 4 expressed express VBD work_wtnfwgpzqnfabpwucygbl35wyq 9 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 9 6 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 9 7 form form NN work_wtnfwgpzqnfabpwucygbl35wyq 9 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 9 9 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 9 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 9 11 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 9 12 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 9 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 9 14 where where WRB work_wtnfwgpzqnfabpwucygbl35wyq 9 15 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 9 16 observed observe VBD work_wtnfwgpzqnfabpwucygbl35wyq 9 17 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 9 18 failure failure NN work_wtnfwgpzqnfabpwucygbl35wyq 9 19 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 9 20 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 9 21 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 9 22 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 9 23 localise localise VB work_wtnfwgpzqnfabpwucygbl35wyq 9 24 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 9 25 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 9 26 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 9 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 9 28 leading lead VBG work_wtnfwgpzqnfabpwucygbl35wyq 9 29 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 9 30 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 9 31 failure failure NN work_wtnfwgpzqnfabpwucygbl35wyq 9 32 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 9 33 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 9 34 daughter daughter NN work_wtnfwgpzqnfabpwucygbl35wyq 9 35 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 9 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 10 1 Conclusions conclusion NNS work_wtnfwgpzqnfabpwucygbl35wyq 10 2 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 10 3 loss loss NN work_wtnfwgpzqnfabpwucygbl35wyq 10 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 10 5 function function NN work_wtnfwgpzqnfabpwucygbl35wyq 10 6 mutations mutation NNS work_wtnfwgpzqnfabpwucygbl35wyq 10 7 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 10 8 underlie underlie NN work_wtnfwgpzqnfabpwucygbl35wyq 10 9 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 10 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 10 11 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 10 12 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 10 13 multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 10 14 congenital congenital NN work_wtnfwgpzqnfabpwucygbl35wyq 10 15 anomaly anomaly IN work_wtnfwgpzqnfabpwucygbl35wyq 10 16 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 10 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 11 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 11 2 association association NN work_wtnfwgpzqnfabpwucygbl35wyq 11 3 expands expand VBZ work_wtnfwgpzqnfabpwucygbl35wyq 11 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 11 5 involvement involvement NN work_wtnfwgpzqnfabpwucygbl35wyq 11 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 11 7 centrosomal centrosomal NN work_wtnfwgpzqnfabpwucygbl35wyq 11 8 proteins protein NNS work_wtnfwgpzqnfabpwucygbl35wyq 11 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 11 10 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 11 11 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 11 12 disorders disorder NNS work_wtnfwgpzqnfabpwucygbl35wyq 11 13 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 11 14 highlighting highlight VBG work_wtnfwgpzqnfabpwucygbl35wyq 11 15 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 11 16 role role NN work_wtnfwgpzqnfabpwucygbl35wyq 11 17 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 11 18 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 11 19 function function NN work_wtnfwgpzqnfabpwucygbl35wyq 11 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 12 1 INTRODUCTION INTRODUCTION NNP work_wtnfwgpzqnfabpwucygbl35wyq 12 2 Hydranencephaly Hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 12 3 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 12 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 12 5 congenital congenital NN work_wtnfwgpzqnfabpwucygbl35wyq 12 6 anomaly anomaly IN work_wtnfwgpzqnfabpwucygbl35wyq 12 7 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 12 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 12 9 frequency frequency NN work_wtnfwgpzqnfabpwucygbl35wyq 12 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 12 11 ∼1 ∼1 NNS work_wtnfwgpzqnfabpwucygbl35wyq 12 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 12 13 10 10 CD work_wtnfwgpzqnfabpwucygbl35wyq 12 14 000 000 CD work_wtnfwgpzqnfabpwucygbl35wyq 12 15 births.1 births.1 CD work_wtnfwgpzqnfabpwucygbl35wyq 12 16 It -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 12 17 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 12 18 defined define VBN work_wtnfwgpzqnfabpwucygbl35wyq 12 19 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 12 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 12 21 almost almost RB work_wtnfwgpzqnfabpwucygbl35wyq 12 22 complete complete JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 23 absence absence NN work_wtnfwgpzqnfabpwucygbl35wyq 12 24 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 12 25 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 12 26 cerebral cerebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 27 hemi- hemi- NN work_wtnfwgpzqnfabpwucygbl35wyq 12 28 spheres sphere NNS work_wtnfwgpzqnfabpwucygbl35wyq 12 29 , , , work_wtnfwgpzqnfabpwucygbl35wyq 12 30 replacement replacement NN work_wtnfwgpzqnfabpwucygbl35wyq 12 31 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 12 32 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 12 33 missing miss VBG work_wtnfwgpzqnfabpwucygbl35wyq 12 34 neural neural JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 35 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 12 36 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 12 37 fluid fluid NN work_wtnfwgpzqnfabpwucygbl35wyq 12 38 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 12 39 filled fill VBN work_wtnfwgpzqnfabpwucygbl35wyq 12 40 sacs sacs NN work_wtnfwgpzqnfabpwucygbl35wyq 12 41 , , , work_wtnfwgpzqnfabpwucygbl35wyq 12 42 relative relative JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 43 preservation preservation NN work_wtnfwgpzqnfabpwucygbl35wyq 12 44 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 12 45 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 12 46 posterior posterior NN work_wtnfwgpzqnfabpwucygbl35wyq 12 47 fossa fossa JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 48 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 12 49 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 12 50 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 12 51 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 52 intracranial intracranial JJ work_wtnfwgpzqnfabpwucygbl35wyq 12 53 compartment compartment NN work_wtnfwgpzqnfabpwucygbl35wyq 12 54 . . . work_wtnfwgpzqnfabpwucygbl35wyq 13 1 On on IN work_wtnfwgpzqnfabpwucygbl35wyq 13 2 prenatal prenatal JJ work_wtnfwgpzqnfabpwucygbl35wyq 13 3 ultrasonography ultrasonography NN work_wtnfwgpzqnfabpwucygbl35wyq 13 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 13 5 hydra- hydra- NNP work_wtnfwgpzqnfabpwucygbl35wyq 13 6 nencephaly nencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 13 7 may may MD work_wtnfwgpzqnfabpwucygbl35wyq 13 8 resemble resemble VB work_wtnfwgpzqnfabpwucygbl35wyq 13 9 extreme extreme JJ work_wtnfwgpzqnfabpwucygbl35wyq 13 10 hydrocephalus hydrocephalus NN work_wtnfwgpzqnfabpwucygbl35wyq 13 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 13 12 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 13 13 can can MD work_wtnfwgpzqnfabpwucygbl35wyq 13 14 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 13 15 differentiated differentiate VBN work_wtnfwgpzqnfabpwucygbl35wyq 13 16 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 13 17 fetal fetal JJ work_wtnfwgpzqnfabpwucygbl35wyq 13 18 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 13 19 postnatal postnatal JJ work_wtnfwgpzqnfabpwucygbl35wyq 13 20 MRI mri NN work_wtnfwgpzqnfabpwucygbl35wyq 13 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 14 1 It -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 14 2 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 14 3 usually usually RB work_wtnfwgpzqnfabpwucygbl35wyq 14 4 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 14 5 isolated isolate VBN work_wtnfwgpzqnfabpwucygbl35wyq 14 6 anomaly anomaly IN work_wtnfwgpzqnfabpwucygbl35wyq 14 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 14 8 although although IN work_wtnfwgpzqnfabpwucygbl35wyq 14 9 there there EX work_wtnfwgpzqnfabpwucygbl35wyq 14 10 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 14 11 reports report NNS work_wtnfwgpzqnfabpwucygbl35wyq 14 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 14 13 syndromic syndromic JJ work_wtnfwgpzqnfabpwucygbl35wyq 14 14 associations association NNS work_wtnfwgpzqnfabpwucygbl35wyq 14 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 15 1 Underlying underlie VBG work_wtnfwgpzqnfabpwucygbl35wyq 15 2 causes cause NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 3 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 15 4 thought think VBN work_wtnfwgpzqnfabpwucygbl35wyq 15 5 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 15 6 include include VB work_wtnfwgpzqnfabpwucygbl35wyq 15 7 teratogens teratogen NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 15 9 eg eg UH work_wtnfwgpzqnfabpwucygbl35wyq 15 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 11 congenital congenital JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 12 infections infection NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 14 valproic valproic JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 15 acid acid NN work_wtnfwgpzqnfabpwucygbl35wyq 15 16 exposure exposure NN work_wtnfwgpzqnfabpwucygbl35wyq 15 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 15 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 19 chromosomal chromosomal NN work_wtnfwgpzqnfabpwucygbl35wyq 15 20 disorders disorder NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 15 22 eg eg NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 24 trisomy trisomy JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 25 13 13 CD work_wtnfwgpzqnfabpwucygbl35wyq 15 26 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 27 triploidy triploidy NN work_wtnfwgpzqnfabpwucygbl35wyq 15 28 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 15 29 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 15 30 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 31 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 15 32 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 15 33 disorders disorder NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 34 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 15 35 eg eg NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 37 proliferative proliferative JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 38 vasculo- vasculo- NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 39 pathy pathy NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 41 X X NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 42 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 15 43 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 15 44 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 15 45 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 15 46 abnormal abnormal JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 47 genitalia).2 genitalia).2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 48 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 15 49 pathophysiology pathophysiology NN work_wtnfwgpzqnfabpwucygbl35wyq 15 50 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 15 51 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 15 52 majority majority NN work_wtnfwgpzqnfabpwucygbl35wyq 15 53 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 15 54 cases case NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 55 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 15 56 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 15 57 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 15 58 thought think VBN work_wtnfwgpzqnfabpwucygbl35wyq 15 59 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 15 60 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 15 61 early early JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 62 intracranial intracranial JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 63 vascular vascular JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 64 obstruction obstruction NN work_wtnfwgpzqnfabpwucygbl35wyq 15 65 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 15 66 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 15 67 fetus fetus NN work_wtnfwgpzqnfabpwucygbl35wyq 15 68 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 69 leading lead VBG work_wtnfwgpzqnfabpwucygbl35wyq 15 70 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 15 71 necrosis necrosis NN work_wtnfwgpzqnfabpwucygbl35wyq 15 72 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 15 73 cystic cystic JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 74 degeneration degeneration NN work_wtnfwgpzqnfabpwucygbl35wyq 15 75 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 15 76 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 15 77 cerebral cerebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 78 hemispheres hemisphere NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 79 , , , work_wtnfwgpzqnfabpwucygbl35wyq 15 80 although although IN work_wtnfwgpzqnfabpwucygbl35wyq 15 81 there there EX work_wtnfwgpzqnfabpwucygbl35wyq 15 82 may may MD work_wtnfwgpzqnfabpwucygbl35wyq 15 83 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 15 84 other other JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 85 mechan- mechan- NN work_wtnfwgpzqnfabpwucygbl35wyq 15 86 isms.2–4 isms.2–4 . work_wtnfwgpzqnfabpwucygbl35wyq 15 87 Here here RB work_wtnfwgpzqnfabpwucygbl35wyq 15 88 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 15 89 report report VBP work_wtnfwgpzqnfabpwucygbl35wyq 15 90 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 15 91 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 15 92 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 15 93 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 15 94 apparently apparently RB work_wtnfwgpzqnfabpwucygbl35wyq 15 95 auto- auto- FW work_wtnfwgpzqnfabpwucygbl35wyq 15 96 somal somal JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 97 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 98 form form NN work_wtnfwgpzqnfabpwucygbl35wyq 15 99 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 15 100 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 15 101 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 15 102 includes include VBZ work_wtnfwgpzqnfabpwucygbl35wyq 15 103 additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 104 congenital congenital JJ work_wtnfwgpzqnfabpwucygbl35wyq 15 105 anomalies anomaly NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 106 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 15 107 dys- dys- NNP work_wtnfwgpzqnfabpwucygbl35wyq 15 108 morphisms morphism NNS work_wtnfwgpzqnfabpwucygbl35wyq 15 109 . . . work_wtnfwgpzqnfabpwucygbl35wyq 16 1 Literature literature NN work_wtnfwgpzqnfabpwucygbl35wyq 16 2 review review NN work_wtnfwgpzqnfabpwucygbl35wyq 16 3 shows show VBZ work_wtnfwgpzqnfabpwucygbl35wyq 16 4 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 16 5 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 16 6 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 16 7 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 16 8 rare rare JJ work_wtnfwgpzqnfabpwucygbl35wyq 16 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 16 10 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 16 11 consistent consistent JJ work_wtnfwgpzqnfabpwucygbl35wyq 16 12 , , , work_wtnfwgpzqnfabpwucygbl35wyq 16 13 syndromic syndromic NNP work_wtnfwgpzqnfabpwucygbl35wyq 16 14 association association NNP work_wtnfwgpzqnfabpwucygbl35wyq 16 15 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 16 16 pro- pro- NN work_wtnfwgpzqnfabpwucygbl35wyq 16 17 vides vide VBZ work_wtnfwgpzqnfabpwucygbl35wyq 16 18 additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 16 19 evidence evidence NN work_wtnfwgpzqnfabpwucygbl35wyq 16 20 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 16 21 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 16 22 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 16 23 inheritance inheritance NN work_wtnfwgpzqnfabpwucygbl35wyq 16 24 pattern pattern NN work_wtnfwgpzqnfabpwucygbl35wyq 16 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 17 1 Neuropathological neuropathological JJ work_wtnfwgpzqnfabpwucygbl35wyq 17 2 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 17 3 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 17 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 17 5 unique unique JJ work_wtnfwgpzqnfabpwucygbl35wyq 17 6 pathophysiology pathophysiology NN work_wtnfwgpzqnfabpwucygbl35wyq 17 7 underlying underlie VBG work_wtnfwgpzqnfabpwucygbl35wyq 17 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 17 9 hydranence- hydranence- VBG work_wtnfwgpzqnfabpwucygbl35wyq 17 10 phaly phaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 17 11 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 17 12 related relate VBN work_wtnfwgpzqnfabpwucygbl35wyq 17 13 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 17 14 arrested arrest VBN work_wtnfwgpzqnfabpwucygbl35wyq 17 15 neuronal neuronal JJ work_wtnfwgpzqnfabpwucygbl35wyq 17 16 mitosis mitosis NN work_wtnfwgpzqnfabpwucygbl35wyq 17 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 17 18 suggesting suggest VBG work_wtnfwgpzqnfabpwucygbl35wyq 17 19 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 17 20 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 17 21 anomaly anomaly IN work_wtnfwgpzqnfabpwucygbl35wyq 17 22 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 17 23 probably probably RB work_wtnfwgpzqnfabpwucygbl35wyq 17 24 caused cause VBN work_wtnfwgpzqnfabpwucygbl35wyq 17 25 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 17 26 non non JJ work_wtnfwgpzqnfabpwucygbl35wyq 17 27 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 17 28 vascular vascular JJ work_wtnfwgpzqnfabpwucygbl35wyq 17 29 mechanisms mechanism NNS work_wtnfwgpzqnfabpwucygbl35wyq 17 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 18 1 Through through IN work_wtnfwgpzqnfabpwucygbl35wyq 18 2 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 18 3 combined combine VBN work_wtnfwgpzqnfabpwucygbl35wyq 18 4 application application NN work_wtnfwgpzqnfabpwucygbl35wyq 18 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 18 6 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 18 7 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 18 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 18 9 exome exome NN work_wtnfwgpzqnfabpwucygbl35wyq 18 10 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 18 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 18 12 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 18 13 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 18 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 18 15 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 18 16 causative causative JJ work_wtnfwgpzqnfabpwucygbl35wyq 18 17 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 18 18 defect defect NN work_wtnfwgpzqnfabpwucygbl35wyq 18 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 18 20 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 18 21 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 18 22 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 18 23 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 18 24 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 18 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 18 26 c.1274C c.1274c XX work_wtnfwgpzqnfabpwucygbl35wyq 18 27 > > FW work_wtnfwgpzqnfabpwucygbl35wyq 18 28 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 18 29 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 18 30 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 18 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 18 32 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 18 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 18 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 18 35 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 18 36 encodes encode VBZ work_wtnfwgpzqnfabpwucygbl35wyq 18 37 centroso- centroso- VBP work_wtnfwgpzqnfabpwucygbl35wyq 18 38 mal mal NNP work_wtnfwgpzqnfabpwucygbl35wyq 18 39 protein-55 protein-55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 18 40 kDa kDa NNP work_wtnfwgpzqnfabpwucygbl35wyq 18 41 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 18 42 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 18 43 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 18 44 . . . work_wtnfwgpzqnfabpwucygbl35wyq 19 1 Although although IN work_wtnfwgpzqnfabpwucygbl35wyq 19 2 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 19 3 impli- impli- JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 4 cated cat VBN work_wtnfwgpzqnfabpwucygbl35wyq 19 5 previously previously RB work_wtnfwgpzqnfabpwucygbl35wyq 19 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 7 any any DT work_wtnfwgpzqnfabpwucygbl35wyq 19 8 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 9 disorder disorder NN work_wtnfwgpzqnfabpwucygbl35wyq 19 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 11 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 12 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 19 13 known know VBN work_wtnfwgpzqnfabpwucygbl35wyq 19 14 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 19 15 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 19 16 essential essential JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 17 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 19 18 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 19 final final JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 20 step step NN work_wtnfwgpzqnfabpwucygbl35wyq 19 21 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 19 22 cytokin- cytokin- NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 23 esis esis NN work_wtnfwgpzqnfabpwucygbl35wyq 19 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 25 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 19 26 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 19 27 has have VBZ work_wtnfwgpzqnfabpwucygbl35wyq 19 28 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 19 29 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 19 30 found find VBN work_wtnfwgpzqnfabpwucygbl35wyq 19 31 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 19 32 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 19 33 upre- upre- NN work_wtnfwgpzqnfabpwucygbl35wyq 19 34 gulated gulate VBN work_wtnfwgpzqnfabpwucygbl35wyq 19 35 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 36 some some DT work_wtnfwgpzqnfabpwucygbl35wyq 19 37 tumours.5 tumours.5 , work_wtnfwgpzqnfabpwucygbl35wyq 19 38 More more RBR work_wtnfwgpzqnfabpwucygbl35wyq 19 39 recently recently RB work_wtnfwgpzqnfabpwucygbl35wyq 19 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 41 loss loss NN work_wtnfwgpzqnfabpwucygbl35wyq 19 42 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 19 43 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 44 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 45 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 46 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 47 ortholog ortholog NN work_wtnfwgpzqnfabpwucygbl35wyq 19 48 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 19 49 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 50 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 51 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 19 52 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 19 53 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 19 54 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 19 55 result result VB work_wtnfwgpzqnfabpwucygbl35wyq 19 56 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 57 various various JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 58 developmental developmental JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 59 defects defect NNS work_wtnfwgpzqnfabpwucygbl35wyq 19 60 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 61 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 62 embryos.6 embryos.6 NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 63 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 64 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 65 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 66 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 19 67 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 68 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 19 69 link link VBP work_wtnfwgpzqnfabpwucygbl35wyq 19 70 aberrant aberrant JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 71 fetal fetal JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 72 development development NN work_wtnfwgpzqnfabpwucygbl35wyq 19 73 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 74 humans human NNS work_wtnfwgpzqnfabpwucygbl35wyq 19 75 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 19 76 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 19 77 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 78 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 19 79 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 19 80 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 19 81 reproduce reproduce VBP work_wtnfwgpzqnfabpwucygbl35wyq 19 82 several several JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 83 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 19 84 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 85 key key JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 86 pheno- pheno- JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 87 types type NNS work_wtnfwgpzqnfabpwucygbl35wyq 19 88 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 19 89 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 90 models model NNS work_wtnfwgpzqnfabpwucygbl35wyq 19 91 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 19 92 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 19 93 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 19 94 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 19 95 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 96 observed observed JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 97 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 98 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 19 99 terminal terminal NN work_wtnfwgpzqnfabpwucygbl35wyq 19 100 truncation truncation NN work_wtnfwgpzqnfabpwucygbl35wyq 19 101 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 19 102 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 103 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 19 104 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 19 105 interferes interfere VBZ work_wtnfwgpzqnfabpwucygbl35wyq 19 106 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 19 107 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 19 108 midbody midbody JJ work_wtnfwgpzqnfabpwucygbl35wyq 19 109 functions function NNS work_wtnfwgpzqnfabpwucygbl35wyq 19 110 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 19 111 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 19 112 , , , work_wtnfwgpzqnfabpwucygbl35wyq 19 113 thereby thereby RB work_wtnfwgpzqnfabpwucygbl35wyq 19 114 providing provide VBG work_wtnfwgpzqnfabpwucygbl35wyq 19 115 insight insight NN work_wtnfwgpzqnfabpwucygbl35wyq 19 116 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 19 117 pathomechanism pathomechanism NN work_wtnfwgpzqnfabpwucygbl35wyq 19 118 . . . work_wtnfwgpzqnfabpwucygbl35wyq 20 1 METHODS methods JJ work_wtnfwgpzqnfabpwucygbl35wyq 20 2 Patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 20 3 material material NN work_wtnfwgpzqnfabpwucygbl35wyq 20 4 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 20 5 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 20 6 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 20 7 conducted conduct VBN work_wtnfwgpzqnfabpwucygbl35wyq 20 8 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 20 9 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 20 10 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 20 11 Canadian canadian JJ work_wtnfwgpzqnfabpwucygbl35wyq 20 12 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 20 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 20 14 Dutch dutch JJ work_wtnfwgpzqnfabpwucygbl35wyq 20 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 20 16 German german JJ work_wtnfwgpzqnfabpwucygbl35wyq 20 17 Mennonite Mennonite NNP work_wtnfwgpzqnfabpwucygbl35wyq 20 18 ancestry ancestry NN work_wtnfwgpzqnfabpwucygbl35wyq 20 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 21 1 490 490 CD work_wtnfwgpzqnfabpwucygbl35wyq 21 2 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 21 3   _SP work_wtnfwgpzqnfabpwucygbl35wyq 21 4 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 21 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 21 6 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 21 7   _SP work_wtnfwgpzqnfabpwucygbl35wyq 21 8 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 21 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 22 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 22 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 22 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 22 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 22 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 23 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 23 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 23 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 23 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 23 6 New new JJ work_wtnfwgpzqnfabpwucygbl35wyq 23 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 23 8 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 23 9 cite cite VB work_wtnfwgpzqnfabpwucygbl35wyq 23 10 : : : work_wtnfwgpzqnfabpwucygbl35wyq 23 11 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 12   _SP work_wtnfwgpzqnfabpwucygbl35wyq 23 13 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 23 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 23 15 Arts art NNS work_wtnfwgpzqnfabpwucygbl35wyq 23 16   _SP work_wtnfwgpzqnfabpwucygbl35wyq 23 17 HH HH NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 23 19 Philippe Philippe NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 20   _SP work_wtnfwgpzqnfabpwucygbl35wyq 23 21 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 23 23 et et NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 24   _SP work_wtnfwgpzqnfabpwucygbl35wyq 23 25 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 23 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 24 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 24 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 24 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 24 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 24 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 25 1 ► ► NFP work_wtnfwgpzqnfabpwucygbl35wyq 25 2 Additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 25 3 material material NN work_wtnfwgpzqnfabpwucygbl35wyq 25 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 25 5 published publish VBN work_wtnfwgpzqnfabpwucygbl35wyq 25 6 online online RB work_wtnfwgpzqnfabpwucygbl35wyq 25 7 only only RB work_wtnfwgpzqnfabpwucygbl35wyq 25 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 26 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 26 2 view view VB work_wtnfwgpzqnfabpwucygbl35wyq 26 3 please please UH work_wtnfwgpzqnfabpwucygbl35wyq 26 4 visit visit VB work_wtnfwgpzqnfabpwucygbl35wyq 26 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 26 6 journal journal NNP work_wtnfwgpzqnfabpwucygbl35wyq 26 7 online online RB work_wtnfwgpzqnfabpwucygbl35wyq 26 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 26 9 http://dx.doi.org/10.1136/ http://dx.doi.org/10.1136/ ADD work_wtnfwgpzqnfabpwucygbl35wyq 26 10 jmedgenet-2016 jmedgenet-2016 NNP work_wtnfwgpzqnfabpwucygbl35wyq 26 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 26 12 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 26 13 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 26 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 27 1 For for IN work_wtnfwgpzqnfabpwucygbl35wyq 27 2 numbered numbered JJ work_wtnfwgpzqnfabpwucygbl35wyq 27 3 affiliations affiliation NNS work_wtnfwgpzqnfabpwucygbl35wyq 27 4 see see VBP work_wtnfwgpzqnfabpwucygbl35wyq 27 5 end end NN work_wtnfwgpzqnfabpwucygbl35wyq 27 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 27 7 article article NN work_wtnfwgpzqnfabpwucygbl35wyq 27 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 28 1 Correspondence correspondence NN work_wtnfwgpzqnfabpwucygbl35wyq 28 2 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 28 3 Dr Dr NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 4 Patrick Patrick NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 5 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 7 FE229 FE229 NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 8 Community Community NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 9 Services Services NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 10 Bldg Bldg NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 12 820 820 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 13 Sherbrook Sherbrook NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 14 St. St. NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 16 Winnipeg Winnipeg NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 18 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 20 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 21 MB MB NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 22 R3A r3a VBP work_wtnfwgpzqnfabpwucygbl35wyq 28 23 1R9 1r9 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 24 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 28 25 pfrosk@hsc.mb.ca pfrosk@hsc.mb.ca NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 26 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 28 27 Dr Dr NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 28   _SP work_wtnfwgpzqnfabpwucygbl35wyq 28 29 Erica Erica NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 30 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 31 Davis Davis NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 33 300 300 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 34 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 35 Duke Duke NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 36 St. St. NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 38 Carmichael Carmichael NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 39 Building Building NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 41 Room Room NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 42 47 47 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 43 - - SYM work_wtnfwgpzqnfabpwucygbl35wyq 28 44 104 104 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 46 Durham Durham NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 47 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 48 NC NC NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 49 27701 27701 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 50 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 51 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 28 52 erica.davis@duke.edu erica.davis@duke.edu ADD work_wtnfwgpzqnfabpwucygbl35wyq 28 53 Received received IN work_wtnfwgpzqnfabpwucygbl35wyq 28 54 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 55 September September NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 56 2016 2016 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 57 Revised revise VBD work_wtnfwgpzqnfabpwucygbl35wyq 28 58 8 8 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 59 November November NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 60 2016 2016 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 61 Accepted accept VBN work_wtnfwgpzqnfabpwucygbl35wyq 28 62 14 14 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 63 December December NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 64 2016 2016 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 65 Published publish VBN work_wtnfwgpzqnfabpwucygbl35wyq 28 66 Online Online NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 67 First First NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 68 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 69   _SP work_wtnfwgpzqnfabpwucygbl35wyq 28 70 March March NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 71   _SP work_wtnfwgpzqnfabpwucygbl35wyq 28 72 2017 2017 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 73 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 28 74 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 75 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 76 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 28 77 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 28 78 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 79 , , , work_wtnfwgpzqnfabpwucygbl35wyq 28 80 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 82 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 83 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 84 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 28 85 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 86 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 87 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 88 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 89 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 90 . . . work_wtnfwgpzqnfabpwucygbl35wyq 28 91 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 92 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 28 93 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 94 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 95 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 96 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 97 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 98 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 99 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 100 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 101 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 102 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 103 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 104 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 105 : : : work_wtnfwgpzqnfabpwucygbl35wyq 28 106 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 28 107 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 108 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 28 109 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 110 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 111 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 112 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 28 113 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 114 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 115 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 116 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 117 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 28 118 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 119 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 120 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 121 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 122 : : : work_wtnfwgpzqnfabpwucygbl35wyq 28 123 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 28 124 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 125 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 126 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 127 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 128 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 129 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 130 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 131 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 132 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 133 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 134 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 135 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 136 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 137 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 138 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 28 139 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 140 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 141 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 142 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 143 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 144 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 145 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 28 146 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 147 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 148 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 149 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 28 150 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 151 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 152 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 153 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 154 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 155 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 28 156 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 28 157 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 158 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 28 159 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 28 160 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 28 161 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 162 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 163 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 164 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 28 165 . . . work_wtnfwgpzqnfabpwucygbl35wyq 29 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 29 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 29 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 29 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 12 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 13 http://crossmark.crossref.org/dialog/?doi=10.1136/jmedgenet-2016-104296&domain=pdf&date_stamp=2017-03-22 http://crossmark.crossref.org/dialog/?doi=10.1136/jmedgenet-2016-104296&domain=pdf&date_stamp=2017-03-22 NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 14 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 15 Postmortem Postmortem NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 16 sampling sampling NN work_wtnfwgpzqnfabpwucygbl35wyq 29 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 29 18 pathological pathological JJ work_wtnfwgpzqnfabpwucygbl35wyq 29 19 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 29 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 29 21 karyotype karyotype NNP work_wtnfwgpzqnfabpwucygbl35wyq 29 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 29 23 com- com- NN work_wtnfwgpzqnfabpwucygbl35wyq 29 24 parative parative JJ work_wtnfwgpzqnfabpwucygbl35wyq 29 25 genomic genomic JJ work_wtnfwgpzqnfabpwucygbl35wyq 29 26 hybridisation hybridisation NN work_wtnfwgpzqnfabpwucygbl35wyq 29 27 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 29 28 done do VBN work_wtnfwgpzqnfabpwucygbl35wyq 29 29 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 29 30 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 29 31 provision provision NN work_wtnfwgpzqnfabpwucygbl35wyq 29 32 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 29 33 clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 29 34 care care NN work_wtnfwgpzqnfabpwucygbl35wyq 29 35 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 29 36 standard standard JJ work_wtnfwgpzqnfabpwucygbl35wyq 29 37 protocols protocol NNS work_wtnfwgpzqnfabpwucygbl35wyq 29 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 30 1 All all DT work_wtnfwgpzqnfabpwucygbl35wyq 30 2 subjects subject NNS work_wtnfwgpzqnfabpwucygbl35wyq 30 3 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 30 4 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 30 5 legal legal JJ work_wtnfwgpzqnfabpwucygbl35wyq 30 6 guardians guardian NNS work_wtnfwgpzqnfabpwucygbl35wyq 30 7 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 30 8 gave give VBD work_wtnfwgpzqnfabpwucygbl35wyq 30 9 written write VBN work_wtnfwgpzqnfabpwucygbl35wyq 30 10 informed informed JJ work_wtnfwgpzqnfabpwucygbl35wyq 30 11 consent consent NN work_wtnfwgpzqnfabpwucygbl35wyq 30 12 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 30 13 participate participate VB work_wtnfwgpzqnfabpwucygbl35wyq 30 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 31 1 Genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 31 2 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 31 3 Genotyping Genotyping NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 31 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 31 6 nuclear nuclear JJ work_wtnfwgpzqnfabpwucygbl35wyq 31 7 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 31 8 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 31 9 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 31 10 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 31 11 Illumina Illumina NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 12 Human Human NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 13 Omni Omni NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 14 2.5 2.5 CD work_wtnfwgpzqnfabpwucygbl35wyq 31 15 SNP SNP NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 16 arrays array VBZ work_wtnfwgpzqnfabpwucygbl35wyq 31 17 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 31 18 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 31 19 Centre Centre NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 20 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 31 21 Applied Applied NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 22 Genomics Genomics NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 31 24 Toronto Toronto NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 31 26 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 31 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 32 1 These these DT work_wtnfwgpzqnfabpwucygbl35wyq 32 2 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 32 3 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 32 4 analysed analyse VBN work_wtnfwgpzqnfabpwucygbl35wyq 32 5 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 32 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 32 7 AutoSNPa AutoSNPa NNS work_wtnfwgpzqnfabpwucygbl35wyq 32 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 32 9 Phaser Phaser NNP work_wtnfwgpzqnfabpwucygbl35wyq 32 10 SNP SNP NNP work_wtnfwgpzqnfabpwucygbl35wyq 32 11 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 32 12 tools tool NNS work_wtnfwgpzqnfabpwucygbl35wyq 32 13 developed develop VBD work_wtnfwgpzqnfabpwucygbl35wyq 32 14 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 32 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 32 16 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 32 17 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 32 18 Leeds.7 Leeds.7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 32 19 8 8 CD work_wtnfwgpzqnfabpwucygbl35wyq 32 20 Additionally additionally RB work_wtnfwgpzqnfabpwucygbl35wyq 32 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 32 22 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 32 23 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 32 24 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 32 25 markers marker NNS work_wtnfwgpzqnfabpwucygbl35wyq 32 26 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 32 27 sorted sort VBN work_wtnfwgpzqnfabpwucygbl35wyq 32 28 manually manually RB work_wtnfwgpzqnfabpwucygbl35wyq 32 29 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 32 30 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 32 31 spreadsheet spreadsheet NN work_wtnfwgpzqnfabpwucygbl35wyq 32 32 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 32 33 determine determine VB work_wtnfwgpzqnfabpwucygbl35wyq 32 34 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 32 35 - - NN work_wtnfwgpzqnfabpwucygbl35wyq 32 36 chromosome chromosome NN work_wtnfwgpzqnfabpwucygbl35wyq 32 37 segregation segregation NN work_wtnfwgpzqnfabpwucygbl35wyq 32 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 33 1 Exome exome JJ work_wtnfwgpzqnfabpwucygbl35wyq 33 2 sequencing sequence VBG work_wtnfwgpzqnfabpwucygbl35wyq 33 3 Sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 33 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 33 5 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 33 6 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 33 7 conducted conduct VBN work_wtnfwgpzqnfabpwucygbl35wyq 33 8 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 33 9 described.9 described.9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 10 Briefly Briefly NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 33 12 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 33 13 enriched enrich VBD work_wtnfwgpzqnfabpwucygbl35wyq 33 14 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 33 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 33 16 coding code VBG work_wtnfwgpzqnfabpwucygbl35wyq 33 17 sequence sequence NN work_wtnfwgpzqnfabpwucygbl35wyq 33 18 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 33 19 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 33 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 33 21 Agilent Agilent NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 22 SureSelect SureSelect NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 23 50 50 CD work_wtnfwgpzqnfabpwucygbl35wyq 33 24 Mb Mb NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 33 26 V3 V3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 33 28 All all DT work_wtnfwgpzqnfabpwucygbl35wyq 33 29 Exon Exon NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 30 Kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 33 31 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 33 32 Agilent Agilent NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 33 Technologies Technologies NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 33 35 Santa Santa NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 36 Clara Clara NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 33 38 California California NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 33 40 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 33 41 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 33 42 . . . work_wtnfwgpzqnfabpwucygbl35wyq 34 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 34 2 resultant resultant JJ work_wtnfwgpzqnfabpwucygbl35wyq 34 3 library library NN work_wtnfwgpzqnfabpwucygbl35wyq 34 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 34 5 sequenced sequence VBN work_wtnfwgpzqnfabpwucygbl35wyq 34 6 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 34 7 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 34 8 Illumina Illumina NNP work_wtnfwgpzqnfabpwucygbl35wyq 34 9 HiSeq HiSeq NNP work_wtnfwgpzqnfabpwucygbl35wyq 34 10 platform platform NN work_wtnfwgpzqnfabpwucygbl35wyq 34 11 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 34 12 generate generate VB work_wtnfwgpzqnfabpwucygbl35wyq 34 13 > > NNP work_wtnfwgpzqnfabpwucygbl35wyq 34 14 14 14 CD work_wtnfwgpzqnfabpwucygbl35wyq 34 15 Gb Gb NNP work_wtnfwgpzqnfabpwucygbl35wyq 34 16 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 34 17 100 100 CD work_wtnfwgpzqnfabpwucygbl35wyq 34 18 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 34 19 paired pair VBN work_wtnfwgpzqnfabpwucygbl35wyq 34 20 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 34 21 end end NN work_wtnfwgpzqnfabpwucygbl35wyq 34 22 reads read NNS work_wtnfwgpzqnfabpwucygbl35wyq 34 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 35 1 Read read VB work_wtnfwgpzqnfabpwucygbl35wyq 35 2 alignment alignment NN work_wtnfwgpzqnfabpwucygbl35wyq 35 3 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 35 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 35 5 reference reference NN work_wtnfwgpzqnfabpwucygbl35wyq 35 6 genome genome NN work_wtnfwgpzqnfabpwucygbl35wyq 35 7 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 35 8 hg19 hg19 NNP work_wtnfwgpzqnfabpwucygbl35wyq 35 9 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 35 10 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 35 11 done do VBN work_wtnfwgpzqnfabpwucygbl35wyq 35 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 35 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 35 14 Burrows Burrows NNP work_wtnfwgpzqnfabpwucygbl35wyq 35 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 35 16 Wheeler Wheeler NNP work_wtnfwgpzqnfabpwucygbl35wyq 35 17 Aligner Aligner NNP work_wtnfwgpzqnfabpwucygbl35wyq 35 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 36 1 Picard Picard NNP work_wtnfwgpzqnfabpwucygbl35wyq 36 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 36 3 ANNOVAR ANNOVAR NNP work_wtnfwgpzqnfabpwucygbl35wyq 36 4 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 36 5 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 36 6 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 36 7 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 36 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 36 9 annotate annotate VB work_wtnfwgpzqnfabpwucygbl35wyq 36 10 var- var- NN work_wtnfwgpzqnfabpwucygbl35wyq 36 11 iants iant NNS work_wtnfwgpzqnfabpwucygbl35wyq 36 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 37 1 Variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 37 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 37 3 low low JJ work_wtnfwgpzqnfabpwucygbl35wyq 37 4 quality quality NN work_wtnfwgpzqnfabpwucygbl35wyq 37 5 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 37 6 did do VBD work_wtnfwgpzqnfabpwucygbl35wyq 37 7 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 37 8 meet meet VB work_wtnfwgpzqnfabpwucygbl35wyq 37 9 objective objective JJ work_wtnfwgpzqnfabpwucygbl35wyq 37 10 criteria criterion NNS work_wtnfwgpzqnfabpwucygbl35wyq 37 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 12 read read VBN work_wtnfwgpzqnfabpwucygbl35wyq 37 13 depth depth NN work_wtnfwgpzqnfabpwucygbl35wyq 37 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 15 DP)>5 DP)>5 NNP work_wtnfwgpzqnfabpwucygbl35wyq 37 16 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 37 17 quality quality NN work_wtnfwgpzqnfabpwucygbl35wyq 37 18 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 19 Q Q NNP work_wtnfwgpzqnfabpwucygbl35wyq 37 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 21 ≥50 ≥50 NN work_wtnfwgpzqnfabpwucygbl35wyq 37 22 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 37 23 mapping map VBG work_wtnfwgpzqnfabpwucygbl35wyq 37 24 quality quality NN work_wtnfwgpzqnfabpwucygbl35wyq 37 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 26 MQ)≥4 MQ)≥4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 37 27 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 37 28 quality quality NN work_wtnfwgpzqnfabpwucygbl35wyq 37 29 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 37 30 depth depth NN work_wtnfwgpzqnfabpwucygbl35wyq 37 31 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 32 QD)<1.5 QD)<1.5 NFP work_wtnfwgpzqnfabpwucygbl35wyq 37 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 37 34 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 37 35 excluded exclude VBN work_wtnfwgpzqnfabpwucygbl35wyq 37 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 38 1 Coverage coverage NN work_wtnfwgpzqnfabpwucygbl35wyq 38 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 38 3 Consensus Consensus NNP work_wtnfwgpzqnfabpwucygbl35wyq 38 4 Coding Coding NNP work_wtnfwgpzqnfabpwucygbl35wyq 38 5 Sequence Sequence NNP work_wtnfwgpzqnfabpwucygbl35wyq 38 6 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 38 7 CCDS ccds NN work_wtnfwgpzqnfabpwucygbl35wyq 38 8 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 38 9 bases basis NNS work_wtnfwgpzqnfabpwucygbl35wyq 38 10 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 38 11 assessed assess VBN work_wtnfwgpzqnfabpwucygbl35wyq 38 12 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 38 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 38 14 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 38 15 Analysis Analysis NNP work_wtnfwgpzqnfabpwucygbl35wyq 38 16 Toolkit Toolkit NNP work_wtnfwgpzqnfabpwucygbl35wyq 38 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 39 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 39 2 assessed assess VBD work_wtnfwgpzqnfabpwucygbl35wyq 39 3 population population NN work_wtnfwgpzqnfabpwucygbl35wyq 39 4 frequency frequency NN work_wtnfwgpzqnfabpwucygbl35wyq 39 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 39 6 variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 39 7 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 39 8 dbSNP132 dbSNP132 NNP work_wtnfwgpzqnfabpwucygbl35wyq 39 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 39 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 39 11 1000 1000 CD work_wtnfwgpzqnfabpwucygbl35wyq 39 12 Genomes Genomes NNP work_wtnfwgpzqnfabpwucygbl35wyq 39 13 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 39 14 set set NN work_wtnfwgpzqnfabpwucygbl35wyq 39 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 39 16 2012/ 2012/ CD work_wtnfwgpzqnfabpwucygbl35wyq 39 17 04 04 CD work_wtnfwgpzqnfabpwucygbl35wyq 39 18 release release NN work_wtnfwgpzqnfabpwucygbl35wyq 39 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 39 20 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 39 21 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 39 22 6500 6500 CD work_wtnfwgpzqnfabpwucygbl35wyq 39 23 exomes exome VBZ work_wtnfwgpzqnfabpwucygbl35wyq 39 24 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 39 25 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 39 26 NHLBI NHLBI NNP work_wtnfwgpzqnfabpwucygbl35wyq 39 27 Exome Exome NNP work_wtnfwgpzqnfabpwucygbl35wyq 39 28 Variant Variant NNP work_wtnfwgpzqnfabpwucygbl35wyq 39 29 Server Server NNP work_wtnfwgpzqnfabpwucygbl35wyq 39 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 40 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 40 2 addition addition NN work_wtnfwgpzqnfabpwucygbl35wyq 40 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 40 4 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 40 5 assessed assess VBD work_wtnfwgpzqnfabpwucygbl35wyq 40 6 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 40 7 frequency frequency NN work_wtnfwgpzqnfabpwucygbl35wyq 40 8 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 40 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 40 10 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 40 11 Quebec Quebec NNP work_wtnfwgpzqnfabpwucygbl35wyq 40 12 Innovation Innovation NNP work_wtnfwgpzqnfabpwucygbl35wyq 40 13 Centre Centre NNP work_wtnfwgpzqnfabpwucygbl35wyq 40 14 database database NN work_wtnfwgpzqnfabpwucygbl35wyq 40 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 40 16 ∼800 ∼800 NNP work_wtnfwgpzqnfabpwucygbl35wyq 40 17 exomes exome VBZ work_wtnfwgpzqnfabpwucygbl35wyq 40 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 40 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 41 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 41 2 confirmed confirm VBD work_wtnfwgpzqnfabpwucygbl35wyq 41 3 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 41 4 candidate candidate NN work_wtnfwgpzqnfabpwucygbl35wyq 41 5 variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 41 6 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 41 7 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 41 8 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 41 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 42 1 RNA rna VB work_wtnfwgpzqnfabpwucygbl35wyq 42 2 isolation isolation NN work_wtnfwgpzqnfabpwucygbl35wyq 42 3 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 42 4 patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 42 5 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 42 7 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 42 8 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 9 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 42 10 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 42 12 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 13 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 42 14 isolated isolate VBD work_wtnfwgpzqnfabpwucygbl35wyq 42 15 total total NN work_wtnfwgpzqnfabpwucygbl35wyq 42 16 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 17 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 42 18 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 19 derived derive VBN work_wtnfwgpzqnfabpwucygbl35wyq 42 20 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 42 21 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 42 22 healthy healthy JJ work_wtnfwgpzqnfabpwucygbl35wyq 42 23 individual individual NN work_wtnfwgpzqnfabpwucygbl35wyq 42 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 42 25 3384 3384 CD work_wtnfwgpzqnfabpwucygbl35wyq 42 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 42 27 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 42 28 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 42 29 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 42 30 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 42 32 anhydramnios anhydramnio NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 42 34 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 42 35 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 42 37 cerebellar cerebellar NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 38 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 42 40 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 42 41 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 42 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 42 43 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 44 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 42 45 patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 42 46 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 42 47 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 42 48 RNeasy RNeasy NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 49 Mini Mini NNP work_wtnfwgpzqnfabpwucygbl35wyq 42 50 Kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 42 51 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 42 52 QIAGEN qiagen NN work_wtnfwgpzqnfabpwucygbl35wyq 42 53 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 42 54 according accord VBG work_wtnfwgpzqnfabpwucygbl35wyq 42 55 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 42 56 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 42 57 manufacturer manufacturer NN work_wtnfwgpzqnfabpwucygbl35wyq 42 58 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 42 59 instructions instruction NNS work_wtnfwgpzqnfabpwucygbl35wyq 42 60 . . . work_wtnfwgpzqnfabpwucygbl35wyq 43 1 cDNA cDNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 2 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 43 3 made make VBN work_wtnfwgpzqnfabpwucygbl35wyq 43 4 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 43 5 SuperScript SuperScript NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 6 III III NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 7 First First NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 8 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 43 9 Strand Strand NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 10 Synthesis Synthesis NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 11 System System NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 43 13 oligo oligo NNS work_wtnfwgpzqnfabpwucygbl35wyq 43 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 43 15 dT)20 dt)20 NN work_wtnfwgpzqnfabpwucygbl35wyq 43 16 primers primer NNS work_wtnfwgpzqnfabpwucygbl35wyq 43 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 43 18 Life Life NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 19 Technologies Technologies NNP work_wtnfwgpzqnfabpwucygbl35wyq 43 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 43 21 according accord VBG work_wtnfwgpzqnfabpwucygbl35wyq 43 22 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 43 23 manufacturer manufacturer NN work_wtnfwgpzqnfabpwucygbl35wyq 43 24 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 43 25 instructions instruction NNS work_wtnfwgpzqnfabpwucygbl35wyq 43 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 44 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 44 2 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 3 amplified amplify VBD work_wtnfwgpzqnfabpwucygbl35wyq 44 4 cDNA cdna NN work_wtnfwgpzqnfabpwucygbl35wyq 44 5 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 44 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 44 7 Veriti Veriti NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 8 96-well 96-well CD work_wtnfwgpzqnfabpwucygbl35wyq 44 9 Thermal Thermal NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 10 Cycler Cycler NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 44 12 model model NN work_wtnfwgpzqnfabpwucygbl35wyq 44 13 9902 9902 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 44 15 Applied Applied NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 16 Biosystems Biosystems NNPS work_wtnfwgpzqnfabpwucygbl35wyq 44 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 44 18 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 44 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 44 20 fol- fol- NN work_wtnfwgpzqnfabpwucygbl35wyq 44 21 lowing low VBG work_wtnfwgpzqnfabpwucygbl35wyq 44 22 conditions condition NNS work_wtnfwgpzqnfabpwucygbl35wyq 44 23 : : : work_wtnfwgpzqnfabpwucygbl35wyq 44 24 95 95 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 25 ° ° , work_wtnfwgpzqnfabpwucygbl35wyq 44 26 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 27 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 44 28 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 29 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 44 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 44 31 followed follow VBN work_wtnfwgpzqnfabpwucygbl35wyq 44 32 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 44 33 27 27 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 34 cycles cycle NNS work_wtnfwgpzqnfabpwucygbl35wyq 44 35 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 44 36 95 95 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 37 ° ° , work_wtnfwgpzqnfabpwucygbl35wyq 44 38 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 44 40 60 60 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 41 ° ° NNS work_wtnfwgpzqnfabpwucygbl35wyq 44 42 C c NN work_wtnfwgpzqnfabpwucygbl35wyq 44 43 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 44 44 72 72 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 45 ° ° NNS work_wtnfwgpzqnfabpwucygbl35wyq 44 46 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 47 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 44 48 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 49 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 50 periods period NNS work_wtnfwgpzqnfabpwucygbl35wyq 44 51 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 44 52 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 44 53 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 54 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 44 55 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 44 56 72 72 CD work_wtnfwgpzqnfabpwucygbl35wyq 44 57 ° ° NNS work_wtnfwgpzqnfabpwucygbl35wyq 44 58 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 44 59 . . . work_wtnfwgpzqnfabpwucygbl35wyq 45 1 Specifically specifically RB work_wtnfwgpzqnfabpwucygbl35wyq 45 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 45 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 45 4 amplified amplify VBD work_wtnfwgpzqnfabpwucygbl35wyq 45 5 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 45 6 exons exon NNS work_wtnfwgpzqnfabpwucygbl35wyq 45 7 7–9 7–9 NFP work_wtnfwgpzqnfabpwucygbl35wyq 45 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 45 9 390 390 CD work_wtnfwgpzqnfabpwucygbl35wyq 45 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 45 11 262 262 CD work_wtnfwgpzqnfabpwucygbl35wyq 45 12 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 45 13 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 45 14 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 45 15 exons exon NNS work_wtnfwgpzqnfabpwucygbl35wyq 45 16 2–3 2–3 CD work_wtnfwgpzqnfabpwucygbl35wyq 45 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 45 18 287 287 CD work_wtnfwgpzqnfabpwucygbl35wyq 45 19 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 45 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 45 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 45 22 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 45 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 45 24 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 45 25 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 45 26 GAPDH GAPDH NNP work_wtnfwgpzqnfabpwucygbl35wyq 45 27 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 45 28 fragment fragment NN work_wtnfwgpzqnfabpwucygbl35wyq 45 29 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 45 30 288 288 CD work_wtnfwgpzqnfabpwucygbl35wyq 45 31 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 45 32 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 45 33 . . . work_wtnfwgpzqnfabpwucygbl35wyq 46 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 46 2 obtained obtain VBD work_wtnfwgpzqnfabpwucygbl35wyq 46 3 primers primer NNS work_wtnfwgpzqnfabpwucygbl35wyq 46 4 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 46 5 Sigma Sigma NNP work_wtnfwgpzqnfabpwucygbl35wyq 46 6 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 46 7 Aldrich Aldrich NNP work_wtnfwgpzqnfabpwucygbl35wyq 46 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 47 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 47 2 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 3 390 390 CD work_wtnfwgpzqnfabpwucygbl35wyq 47 4 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 47 5 fragment fragment NN work_wtnfwgpzqnfabpwucygbl35wyq 47 6 I -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 47 7 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 47 8 amplified amplify VBN work_wtnfwgpzqnfabpwucygbl35wyq 47 9 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 47 10 forward forward JJ work_wtnfwgpzqnfabpwucygbl35wyq 47 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 47 12 reverse reverse VB work_wtnfwgpzqnfabpwucygbl35wyq 47 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 47 14 50 50 CD work_wtnfwgpzqnfabpwucygbl35wyq 47 15 - - SYM work_wtnfwgpzqnfabpwucygbl35wyq 47 16 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 47 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 47 18 primers primer NNS work_wtnfwgpzqnfabpwucygbl35wyq 47 19 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 47 20 CCAGTTTCTTTACACATCTCTGC CCAGTTTCTTTACACATCTCTGC NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 21 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 47 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 47 23 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 47 24 CAGTATTCCACATGGACAAGC CAGTATTCCACATGGACAAGC NNS work_wtnfwgpzqnfabpwucygbl35wyq 47 25 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 47 26 , , , work_wtnfwgpzqnfabpwucygbl35wyq 47 27 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 47 28 262 262 CD work_wtnfwgpzqnfabpwucygbl35wyq 47 29 bp bp NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 30 fragment fragment NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 31 II II NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 32 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 47 33 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 47 34 CCAGTTTCTTTACACATCTCTGC CCAGTTTCTTTACACATCTCTGC NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 35 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 47 36 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 47 37 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 47 38 TCTGTTTT TCTGTTTT NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 39 CAGTCTCTCCTTGG CAGTCTCTCCTTGG NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 40 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 47 41 , , , work_wtnfwgpzqnfabpwucygbl35wyq 47 42 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 47 43 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 47 44 287 287 CD work_wtnfwgpzqnfabpwucygbl35wyq 47 45 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 47 46 fragment fragment NN work_wtnfwgpzqnfabpwucygbl35wyq 47 47 III iii CD work_wtnfwgpzqnfabpwucygbl35wyq 47 48 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 47 49 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 47 50 AAGTAAGTGGGGATCGAAGC AAGTAAGTGGGGATCGAAGC NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 51 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 47 52 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 47 53 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 47 54 TCTCTTCCAGCTGTT tctcttccagctgtt JJ work_wtnfwgpzqnfabpwucygbl35wyq 47 55 CAAGC CAAGC NNP work_wtnfwgpzqnfabpwucygbl35wyq 47 56 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 47 57 . . . work_wtnfwgpzqnfabpwucygbl35wyq 48 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 48 2 50 50 CD work_wtnfwgpzqnfabpwucygbl35wyq 48 3 - - SYM work_wtnfwgpzqnfabpwucygbl35wyq 48 4 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 48 5 sequences sequence NNS work_wtnfwgpzqnfabpwucygbl35wyq 48 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 48 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 48 8 GAPDH GAPDH NNP work_wtnfwgpzqnfabpwucygbl35wyq 48 9 primers primer NNS work_wtnfwgpzqnfabpwucygbl35wyq 48 10 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 48 11 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 48 12 TCTCCTCTGACTTCAACAGCGA TCTCCTCTGACTTCAACAGCGA NNP work_wtnfwgpzqnfabpwucygbl35wyq 48 13 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 48 14 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 48 15 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 48 16 TACATGGCAACTGT TACATGGCAACTGT NNP work_wtnfwgpzqnfabpwucygbl35wyq 48 17 GAGGAGGG GAGGAGGG NNP work_wtnfwgpzqnfabpwucygbl35wyq 48 18 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 48 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 49 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 49 2 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 49 3 390 390 CD work_wtnfwgpzqnfabpwucygbl35wyq 49 4 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 49 5 fragment fragment NN work_wtnfwgpzqnfabpwucygbl35wyq 49 6 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 49 7 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 49 8 sequenced sequence VBN work_wtnfwgpzqnfabpwucygbl35wyq 49 9 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 49 10 validate validate VB work_wtnfwgpzqnfabpwucygbl35wyq 49 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 49 12 absence absence NN work_wtnfwgpzqnfabpwucygbl35wyq 49 13 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 49 14 presence presence NN work_wtnfwgpzqnfabpwucygbl35wyq 49 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 49 16 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 49 17 c.1274C c.1274c XX work_wtnfwgpzqnfabpwucygbl35wyq 49 18 > > FW work_wtnfwgpzqnfabpwucygbl35wyq 49 19 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 49 20 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 49 21 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 49 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 49 23 S425X s425x LS work_wtnfwgpzqnfabpwucygbl35wyq 49 24 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 49 25 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 49 26 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 49 27 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 49 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 49 29 patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 49 30 cDNA cdna NN work_wtnfwgpzqnfabpwucygbl35wyq 49 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 49 32 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 49 33 . . . work_wtnfwgpzqnfabpwucygbl35wyq 50 1 Transient transient JJ work_wtnfwgpzqnfabpwucygbl35wyq 50 2 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 50 3 suppression suppression NN work_wtnfwgpzqnfabpwucygbl35wyq 50 4 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 50 5 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 6 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 50 7 All all DT work_wtnfwgpzqnfabpwucygbl35wyq 50 8 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 9 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 50 10 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 50 11 conducted conduct VBN work_wtnfwgpzqnfabpwucygbl35wyq 50 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 50 13 approval approval NN work_wtnfwgpzqnfabpwucygbl35wyq 50 14 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 50 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 50 16 Duke Duke NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 17 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 18 Institutional Institutional NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 19 Animal Animal NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 20 Care Care NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 50 22 Use Use NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 23 Committee Committee NNP work_wtnfwgpzqnfabpwucygbl35wyq 50 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 51 1 Two two CD work_wtnfwgpzqnfabpwucygbl35wyq 51 2 splice splice NN work_wtnfwgpzqnfabpwucygbl35wyq 51 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 51 4 blocking block VBG work_wtnfwgpzqnfabpwucygbl35wyq 51 5 morpholino morpholino NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 6 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 51 7 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 8 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 51 9 antisense antisense NN work_wtnfwgpzqnfabpwucygbl35wyq 51 10 oligonucleo- oligonucleo- NN work_wtnfwgpzqnfabpwucygbl35wyq 51 11 tides tides IN work_wtnfwgpzqnfabpwucygbl35wyq 51 12 targeting target VBG work_wtnfwgpzqnfabpwucygbl35wyq 51 13 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 51 15 sb1 sb1 NN work_wtnfwgpzqnfabpwucygbl35wyq 51 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 51 17 50-CTGAGATAAAGCGACTAATT 50-ctgagataaagcgactaatt CD work_wtnfwgpzqnfabpwucygbl35wyq 51 18 CACCT-30 cacct-30 NN work_wtnfwgpzqnfabpwucygbl35wyq 51 19 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 51 20 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 51 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 51 22 50-GTTGAGCTTTTCTTACCATCAG 50-GTTGAGCTTTTCTTACCATCAG NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 23 ACT-30 act-30 LS work_wtnfwgpzqnfabpwucygbl35wyq 51 24 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 51 25 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 51 26 obtained obtain VBN work_wtnfwgpzqnfabpwucygbl35wyq 51 27 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 51 28 Gene Gene NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 29 Tools Tools NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 51 31 LLC LLC NNP work_wtnfwgpzqnfabpwucygbl35wyq 51 32 . . . work_wtnfwgpzqnfabpwucygbl35wyq 52 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 52 2 determine determine VB work_wtnfwgpzqnfabpwucygbl35wyq 52 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 52 4 optimal optimal NN work_wtnfwgpzqnfabpwucygbl35wyq 52 5 dose dose VB work_wtnfwgpzqnfabpwucygbl35wyq 52 6 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 52 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 52 8 vivo vivo NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 9 complementation complementation NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 10 assays assays RB work_wtnfwgpzqnfabpwucygbl35wyq 52 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 52 12 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 52 13 injected inject VBD work_wtnfwgpzqnfabpwucygbl35wyq 52 14 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 52 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 52 16 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 52 17 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 52 18 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 52 19 ng ng NN work_wtnfwgpzqnfabpwucygbl35wyq 52 20 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 52 21 MO mo NN work_wtnfwgpzqnfabpwucygbl35wyq 52 22 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 52 23 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 52 24 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 52 25 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 52 26 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 52 27 four four CD work_wtnfwgpzqnfabpwucygbl35wyq 52 28 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 52 29 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 52 30 stage stage NN work_wtnfwgpzqnfabpwucygbl35wyq 52 31 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 32 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 52 33 obtained obtain VBN work_wtnfwgpzqnfabpwucygbl35wyq 52 34 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 52 35 natural natural JJ work_wtnfwgpzqnfabpwucygbl35wyq 52 36 matings mating NNS work_wtnfwgpzqnfabpwucygbl35wyq 52 37 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 52 38 heterozygous heterozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 52 39 -1.4col1a1 -1.4col1a1 : work_wtnfwgpzqnfabpwucygbl35wyq 52 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 52 41 egfp egfp NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 42 transgenic transgenic NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 43 adults.10 adults.10 NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 44 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 52 45 determine determine VB work_wtnfwgpzqnfabpwucygbl35wyq 52 46 MO mo NN work_wtnfwgpzqnfabpwucygbl35wyq 52 47 efficiency efficiency NN work_wtnfwgpzqnfabpwucygbl35wyq 52 48 , , , work_wtnfwgpzqnfabpwucygbl35wyq 52 49 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 52 50 harvested harvest VBD work_wtnfwgpzqnfabpwucygbl35wyq 52 51 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 52 52 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 52 53 Trizol Trizol NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 54 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 52 55 Invitrogen Invitrogen NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 56 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 52 57 , , , work_wtnfwgpzqnfabpwucygbl35wyq 52 58 extracted extract VBN work_wtnfwgpzqnfabpwucygbl35wyq 52 59 total total NN work_wtnfwgpzqnfabpwucygbl35wyq 52 60 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 61 according accord VBG work_wtnfwgpzqnfabpwucygbl35wyq 52 62 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 52 63 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 52 64 manufacturer manufacturer NN work_wtnfwgpzqnfabpwucygbl35wyq 52 65 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 52 66 instructions instruction NNS work_wtnfwgpzqnfabpwucygbl35wyq 52 67 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 52 68 generated generate VBN work_wtnfwgpzqnfabpwucygbl35wyq 52 69 oligo oligo NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 70 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 52 71 dT- dT- NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 72 primed prime VBN work_wtnfwgpzqnfabpwucygbl35wyq 52 73 cDNA cdna NN work_wtnfwgpzqnfabpwucygbl35wyq 52 74 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 52 75 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 52 76 QuantiTect QuantiTect NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 77 reverse reverse JJ work_wtnfwgpzqnfabpwucygbl35wyq 52 78 transcription transcription NN work_wtnfwgpzqnfabpwucygbl35wyq 52 79 kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 52 80 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 52 81 Qiagen Qiagen NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 82 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 52 83 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 52 84 use use NN work_wtnfwgpzqnfabpwucygbl35wyq 52 85 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 52 86 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 87 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 52 88 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 52 89 template template NN work_wtnfwgpzqnfabpwucygbl35wyq 52 90 . . . work_wtnfwgpzqnfabpwucygbl35wyq 53 1 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 53 2 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 53 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 53 4 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 53 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 53 6 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 53 7 products product NNS work_wtnfwgpzqnfabpwucygbl35wyq 53 8 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 53 9 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 53 10 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 53 11 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 53 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 53 13 precise precise JJ work_wtnfwgpzqnfabpwucygbl35wyq 53 14 alteration alteration NN work_wtnfwgpzqnfabpwucygbl35wyq 53 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 53 16 endogenous endogenous JJ work_wtnfwgpzqnfabpwucygbl35wyq 53 17 transcript transcript NN work_wtnfwgpzqnfabpwucygbl35wyq 53 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 54 1 For for IN work_wtnfwgpzqnfabpwucygbl35wyq 54 2 rescue rescue NN work_wtnfwgpzqnfabpwucygbl35wyq 54 3 experiments experiment NNS work_wtnfwgpzqnfabpwucygbl35wyq 54 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 54 5 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 54 6 ng ng NN work_wtnfwgpzqnfabpwucygbl35wyq 54 7 MO mo NN work_wtnfwgpzqnfabpwucygbl35wyq 54 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 54 9 100 100 CD work_wtnfwgpzqnfabpwucygbl35wyq 54 10 pg pg NNP work_wtnfwgpzqnfabpwucygbl35wyq 54 11 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 54 12 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 54 13 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 54 14 either either RB work_wtnfwgpzqnfabpwucygbl35wyq 54 15 independently independently RB work_wtnfwgpzqnfabpwucygbl35wyq 54 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 54 17 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 54 18 combined combine VBN work_wtnfwgpzqnfabpwucygbl35wyq 54 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 55 1 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 55 3 CAS9 CAS9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 4 genome genome JJ work_wtnfwgpzqnfabpwucygbl35wyq 55 5 editing editing NN work_wtnfwgpzqnfabpwucygbl35wyq 55 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 55 7 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 8 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 55 9 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 55 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 55 11 CHOPCHOP chopchop NN work_wtnfwgpzqnfabpwucygbl35wyq 55 12 design design NN work_wtnfwgpzqnfabpwucygbl35wyq 55 13 tool tool NN work_wtnfwgpzqnfabpwucygbl35wyq 55 14 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 55 15 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 55 16 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 17 guide guide NN work_wtnfwgpzqnfabpwucygbl35wyq 55 18 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 55 19 g)RNA g)RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 20 target target NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 21 sequences sequence NNS work_wtnfwgpzqnfabpwucygbl35wyq 55 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 55 23 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 55 24 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 55 25 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 55 26 pair pair NN work_wtnfwgpzqnfabpwucygbl35wyq 55 27 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 55 28 oligonucleotides oligonucleotide NNS work_wtnfwgpzqnfabpwucygbl35wyq 55 29 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 55 30 synthesised synthesise VBN work_wtnfwgpzqnfabpwucygbl35wyq 55 31 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 55 32 annealed.11 annealed.11 NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 33 Annealed Annealed NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 34 oligos oligo NNS work_wtnfwgpzqnfabpwucygbl35wyq 55 35 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 55 36 ligated ligate VBN work_wtnfwgpzqnfabpwucygbl35wyq 55 37 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 55 38 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 55 39 T7cas9sgRNA2 T7cas9sgRNA2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 55 40 vector vector NN work_wtnfwgpzqnfabpwucygbl35wyq 55 41 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 55 42 described,12 described,12 NN work_wtnfwgpzqnfabpwucygbl35wyq 55 43 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 55 44 plasmids plasmid NNS work_wtnfwgpzqnfabpwucygbl35wyq 55 45 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 55 46 sequence sequence NN work_wtnfwgpzqnfabpwucygbl35wyq 55 47 confirmed confirm VBD work_wtnfwgpzqnfabpwucygbl35wyq 55 48 . . . work_wtnfwgpzqnfabpwucygbl35wyq 56 1 Template template JJ work_wtnfwgpzqnfabpwucygbl35wyq 56 2 vector vector NN work_wtnfwgpzqnfabpwucygbl35wyq 56 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 56 4 linearised linearise VBN work_wtnfwgpzqnfabpwucygbl35wyq 56 5 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 56 6 BamHI BamHI NNP work_wtnfwgpzqnfabpwucygbl35wyq 56 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 56 8 gRNA gRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 56 9 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 56 10 transcribed transcribe VBN work_wtnfwgpzqnfabpwucygbl35wyq 56 11 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 56 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 56 13 MEGAshortscript MEGAshortscript NNP work_wtnfwgpzqnfabpwucygbl35wyq 56 14 T7 T7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 56 15 kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 56 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 56 17 Life Life NNP work_wtnfwgpzqnfabpwucygbl35wyq 56 18 Technologies Technologies NNPS work_wtnfwgpzqnfabpwucygbl35wyq 56 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 56 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 57 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 57 2 total total NN work_wtnfwgpzqnfabpwucygbl35wyq 57 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 57 4 100 100 CD work_wtnfwgpzqnfabpwucygbl35wyq 57 5 pg pg NN work_wtnfwgpzqnfabpwucygbl35wyq 57 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 57 7 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 57 8 gRNA grna NN work_wtnfwgpzqnfabpwucygbl35wyq 57 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 57 10 100 100 CD work_wtnfwgpzqnfabpwucygbl35wyq 57 11 pg pg NN work_wtnfwgpzqnfabpwucygbl35wyq 57 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 57 13 CAS9 CAS9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 57 14 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 57 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 57 16 PNA PNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 57 17 Bio Bio NNP work_wtnfwgpzqnfabpwucygbl35wyq 57 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 57 19 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 57 20 co co VBN work_wtnfwgpzqnfabpwucygbl35wyq 57 21 - - VBN work_wtnfwgpzqnfabpwucygbl35wyq 57 22 injected inject VBN work_wtnfwgpzqnfabpwucygbl35wyq 57 23 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 57 24 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 57 25 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 57 26 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 57 27 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 57 28 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 57 29 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 57 30 stage stage NN work_wtnfwgpzqnfabpwucygbl35wyq 57 31 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 57 32 . . . work_wtnfwgpzqnfabpwucygbl35wyq 58 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 58 2 determine determine VB work_wtnfwgpzqnfabpwucygbl35wyq 58 3 targeting target VBG work_wtnfwgpzqnfabpwucygbl35wyq 58 4 efficiency efficiency NN work_wtnfwgpzqnfabpwucygbl35wyq 58 5 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 58 6 F0 f0 NN work_wtnfwgpzqnfabpwucygbl35wyq 58 7 mutants mutant NNS work_wtnfwgpzqnfabpwucygbl35wyq 58 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 58 9 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 58 10 harvested harvest VBD work_wtnfwgpzqnfabpwucygbl35wyq 58 11 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 58 12 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 58 13 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 58 14 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 58 15 days day NNS work_wtnfwgpzqnfabpwucygbl35wyq 58 16 post- post- NNP work_wtnfwgpzqnfabpwucygbl35wyq 58 17 fertilisation fertilisation NNP work_wtnfwgpzqnfabpwucygbl35wyq 58 18 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 58 19 dpf dpf NNP work_wtnfwgpzqnfabpwucygbl35wyq 58 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 58 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 58 22 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 58 23 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 58 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 58 25 extracted extract VBD work_wtnfwgpzqnfabpwucygbl35wyq 58 26 genomic genomic NNP work_wtnfwgpzqnfabpwucygbl35wyq 58 27 DNA DNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 58 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 58 29 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 58 30 amplified amplify VBD work_wtnfwgpzqnfabpwucygbl35wyq 58 31 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 58 32 region region NN work_wtnfwgpzqnfabpwucygbl35wyq 58 33 flanking flank VBG work_wtnfwgpzqnfabpwucygbl35wyq 58 34 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 58 35 gRNA grna NN work_wtnfwgpzqnfabpwucygbl35wyq 58 36 target target NN work_wtnfwgpzqnfabpwucygbl35wyq 58 37 site site NN work_wtnfwgpzqnfabpwucygbl35wyq 58 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 59 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 59 2 estimate estimate VB work_wtnfwgpzqnfabpwucygbl35wyq 59 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 59 4 percent percent NN work_wtnfwgpzqnfabpwucygbl35wyq 59 5 mosaicism mosaicism NN work_wtnfwgpzqnfabpwucygbl35wyq 59 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 59 7 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 8 products product NNS work_wtnfwgpzqnfabpwucygbl35wyq 59 9 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 59 10 cloned clone VBN work_wtnfwgpzqnfabpwucygbl35wyq 59 11 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 59 12 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 59 13 TOPO- topo- JJ work_wtnfwgpzqnfabpwucygbl35wyq 59 14 Therapeutic therapeutic JJ work_wtnfwgpzqnfabpwucygbl35wyq 59 15 abortion abortion NN work_wtnfwgpzqnfabpwucygbl35wyq 59 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 17 TA TA NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 19 vector vector NN work_wtnfwgpzqnfabpwucygbl35wyq 59 20 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 21 ThermoFisher ThermoFisher NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 22 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 23 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 59 24 plasmid plasmid NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 25 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 59 26 prepped preppe VBN work_wtnfwgpzqnfabpwucygbl35wyq 59 27 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 59 28 multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 59 29 individual individual JJ work_wtnfwgpzqnfabpwucygbl35wyq 59 30 colonies colony NNS work_wtnfwgpzqnfabpwucygbl35wyq 59 31 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 32 n=19–54 n=19–54 NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 34 per per IN work_wtnfwgpzqnfabpwucygbl35wyq 59 35 embryo embryo NN work_wtnfwgpzqnfabpwucygbl35wyq 59 36 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 37 n=5–8 n=5–8 NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 38 embryos embryos NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 39 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 59 40 condition condition NN work_wtnfwgpzqnfabpwucygbl35wyq 59 41 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 59 42 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 59 43 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 59 44 sequenced sequence VBD work_wtnfwgpzqnfabpwucygbl35wyq 59 45 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 59 46 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 59 47 ABI3730 abi3730 NN work_wtnfwgpzqnfabpwucygbl35wyq 59 48 . . . work_wtnfwgpzqnfabpwucygbl35wyq 60 1 NGS NGS NNP work_wtnfwgpzqnfabpwucygbl35wyq 60 2 library library NN work_wtnfwgpzqnfabpwucygbl35wyq 60 3 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 60 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 60 5 sequencing sequence VBG work_wtnfwgpzqnfabpwucygbl35wyq 60 6 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 60 7 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 60 8 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 60 9 CAS9 CAS9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 60 10 outcomes outcome VBZ work_wtnfwgpzqnfabpwucygbl35wyq 60 11 Gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 60 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 60 13 specific specific JJ work_wtnfwgpzqnfabpwucygbl35wyq 60 14 primers primer NNS work_wtnfwgpzqnfabpwucygbl35wyq 60 15 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 60 16 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 60 17 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 60 18 amplify amplify VB work_wtnfwgpzqnfabpwucygbl35wyq 60 19 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 60 20 region region NN work_wtnfwgpzqnfabpwucygbl35wyq 60 21 flanking flank VBG work_wtnfwgpzqnfabpwucygbl35wyq 60 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 60 23 gRNA grna NN work_wtnfwgpzqnfabpwucygbl35wyq 60 24 target target NN work_wtnfwgpzqnfabpwucygbl35wyq 60 25 site site NN work_wtnfwgpzqnfabpwucygbl35wyq 60 26 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 60 27 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 60 28 tags tag NNS work_wtnfwgpzqnfabpwucygbl35wyq 60 29 50-CGCTCTTCCGATCT 50-cgctcttccgatct CD work_wtnfwgpzqnfabpwucygbl35wyq 60 30 CTG-30 CTG-30 NNS work_wtnfwgpzqnfabpwucygbl35wyq 60 31 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 60 32 50-TGCTCTTCCGATCTGAC-30 50-TGCTCTTCCGATCTGAC-30 NNP work_wtnfwgpzqnfabpwucygbl35wyq 60 33 appended append VBD work_wtnfwgpzqnfabpwucygbl35wyq 60 34 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 60 35 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 60 36 50 50 CD work_wtnfwgpzqnfabpwucygbl35wyq 60 37 side side NN work_wtnfwgpzqnfabpwucygbl35wyq 60 38 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 60 39 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 60 40 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 60 41 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 60 42 specific specific JJ work_wtnfwgpzqnfabpwucygbl35wyq 60 43 portion portion NN work_wtnfwgpzqnfabpwucygbl35wyq 60 44 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 60 45 forward forward RB work_wtnfwgpzqnfabpwucygbl35wyq 60 46 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 60 47 reverse reverse VB work_wtnfwgpzqnfabpwucygbl35wyq 60 48 primers primer NNS work_wtnfwgpzqnfabpwucygbl35wyq 60 49 , , , work_wtnfwgpzqnfabpwucygbl35wyq 60 50 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 60 51 . . . work_wtnfwgpzqnfabpwucygbl35wyq 61 1 These these DT work_wtnfwgpzqnfabpwucygbl35wyq 61 2 amplicons amplicon NNS work_wtnfwgpzqnfabpwucygbl35wyq 61 3 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 61 4 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 61 5 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 61 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 61 7 template template NN work_wtnfwgpzqnfabpwucygbl35wyq 61 8 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 61 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 61 10 second second JJ work_wtnfwgpzqnfabpwucygbl35wyq 61 11 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 61 12 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 61 13 add add VB work_wtnfwgpzqnfabpwucygbl35wyq 61 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 61 15 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 61 16 Xpress Xpress NNP work_wtnfwgpzqnfabpwucygbl35wyq 61 17 barcode barcode NN work_wtnfwgpzqnfabpwucygbl35wyq 61 18 adapters adapter NNS work_wtnfwgpzqnfabpwucygbl35wyq 61 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 62 1 Equimolar equimolar JJ work_wtnfwgpzqnfabpwucygbl35wyq 62 2 concentrations concentration NNS work_wtnfwgpzqnfabpwucygbl35wyq 62 3 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 62 4 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 62 5 amplicon amplicon NN work_wtnfwgpzqnfabpwucygbl35wyq 62 6 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 62 7 pooled pool VBN work_wtnfwgpzqnfabpwucygbl35wyq 62 8 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 62 9 make make VB work_wtnfwgpzqnfabpwucygbl35wyq 62 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 62 11 final final JJ work_wtnfwgpzqnfabpwucygbl35wyq 62 12 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 62 13 library library NN work_wtnfwgpzqnfabpwucygbl35wyq 62 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 63 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 63 2 library library NN work_wtnfwgpzqnfabpwucygbl35wyq 63 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 63 4 diluted dilute VBN work_wtnfwgpzqnfabpwucygbl35wyq 63 5 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 63 6 100 100 CD work_wtnfwgpzqnfabpwucygbl35wyq 63 7 pM pm NN work_wtnfwgpzqnfabpwucygbl35wyq 63 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 63 9 sequencing sequence VBG work_wtnfwgpzqnfabpwucygbl35wyq 63 10 template template NN work_wtnfwgpzqnfabpwucygbl35wyq 63 11 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 63 12 prepared prepare VBN work_wtnfwgpzqnfabpwucygbl35wyq 63 13 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 63 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 63 15 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 63 16 PGM PGM NNP work_wtnfwgpzqnfabpwucygbl35wyq 63 17 Hi Hi NNP work_wtnfwgpzqnfabpwucygbl35wyq 63 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 63 19 Q q NN work_wtnfwgpzqnfabpwucygbl35wyq 63 20 OT2 OT2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 63 21 Kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 63 22 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 63 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 63 24 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 63 25 One one CD work_wtnfwgpzqnfabpwucygbl35wyq 63 26 Touch touch NN work_wtnfwgpzqnfabpwucygbl35wyq 63 27 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 63 28 instrument instrument NN work_wtnfwgpzqnfabpwucygbl35wyq 63 29 according accord VBG work_wtnfwgpzqnfabpwucygbl35wyq 63 30 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 63 31 manufacturer manufacturer NN work_wtnfwgpzqnfabpwucygbl35wyq 63 32 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 63 33 instructions instruction NNS work_wtnfwgpzqnfabpwucygbl35wyq 63 34 . . . work_wtnfwgpzqnfabpwucygbl35wyq 64 1 Templated Templated NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 2 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 3 Sphere Sphere NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 4 Particles Particles NNPS work_wtnfwgpzqnfabpwucygbl35wyq 64 5 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 64 6 enriched enrich VBN work_wtnfwgpzqnfabpwucygbl35wyq 64 7 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 64 8 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 64 9 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 10 One one CD work_wtnfwgpzqnfabpwucygbl35wyq 64 11 Touch touch NN work_wtnfwgpzqnfabpwucygbl35wyq 64 12 ES ES NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 64 14 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 64 15 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 64 16 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 64 17 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 64 18 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 64 19 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 20 Torrent Torrent NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 21 PGM PGM NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 22 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 64 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 64 24 Ion Ion NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 25 PGM PGM NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 26 Hi Hi NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 27 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 64 28 Q Q NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 29 Sequencing Sequencing NNP work_wtnfwgpzqnfabpwucygbl35wyq 64 30 Kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 64 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 65 1 Demultiplexing demultiplexe VBG work_wtnfwgpzqnfabpwucygbl35wyq 65 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 65 3 barcoded barcode VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 4 samples sample NNS work_wtnfwgpzqnfabpwucygbl35wyq 65 5 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 65 6 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 7 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 65 8 Torrent Torrent NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 9 Suite Suite NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 10 Software Software NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 11 5.0.4 5.0.4 NNPS work_wtnfwgpzqnfabpwucygbl35wyq 65 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 65 13 reads read NNS work_wtnfwgpzqnfabpwucygbl35wyq 65 14 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 65 15 trimmed trim VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 16 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 65 17 Cutadapt.13 Cutadapt.13 NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 18 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 19 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 65 20 Cas9 Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 21 outcomes outcome NNS work_wtnfwgpzqnfabpwucygbl35wyq 65 22 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 65 23 quan- quan- NN work_wtnfwgpzqnfabpwucygbl35wyq 65 24 tified tifie VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 25 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 65 26 CRISPResso CRISPResso NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 27 computational computational JJ work_wtnfwgpzqnfabpwucygbl35wyq 65 28 pipeline.14 pipeline.14 NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 29 Automated Automated NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 30 zebrafish zebrafish VBP work_wtnfwgpzqnfabpwucygbl35wyq 65 31 imaging image VBG work_wtnfwgpzqnfabpwucygbl35wyq 65 32 Larvae Larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 33 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 65 34 positioned position VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 35 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 65 36 imaged image VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 37 live live RB work_wtnfwgpzqnfabpwucygbl35wyq 65 38 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 65 39 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 65 40 Vertebrate Vertebrate NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 41 Automated Automated NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 42 Screening Screening NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 43 Technology Technology NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 44 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 65 45 VAST VAST NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 46 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 65 47 platform platform NN work_wtnfwgpzqnfabpwucygbl35wyq 65 48 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 65 49 Union Union NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 50 Biometrica Biometrica NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 51 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 65 52 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 65 53 described.15 described.15 NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 54 Larvae Larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 55 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 65 56 anaesthetised anaesthetise VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 57 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 65 58 0.2 0.2 CD work_wtnfwgpzqnfabpwucygbl35wyq 65 59 mg mg NNS work_wtnfwgpzqnfabpwucygbl35wyq 65 60 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 65 61 mL mL NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 62 Tricaine Tricaine NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 63 prior prior RB work_wtnfwgpzqnfabpwucygbl35wyq 65 64 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 65 65 being be VBG work_wtnfwgpzqnfabpwucygbl35wyq 65 66 loaded load VBN work_wtnfwgpzqnfabpwucygbl35wyq 65 67 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 65 68 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 65 69 sample sample NN work_wtnfwgpzqnfabpwucygbl35wyq 65 70 491Frosk 491Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 71   _SP work_wtnfwgpzqnfabpwucygbl35wyq 65 72 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 73 , , , work_wtnfwgpzqnfabpwucygbl35wyq 65 74 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 65 75   _SP work_wtnfwgpzqnfabpwucygbl35wyq 65 76 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 65 77 . . . work_wtnfwgpzqnfabpwucygbl35wyq 66 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 66 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 66 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 66 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 66 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 67 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 67 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 67 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 67 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 67 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 67 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 67 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 67 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 67 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 67 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 67 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 67 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 67 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 67 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 67 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 67 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 67 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 67 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 67 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 67 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 67 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 67 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 67 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 67 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 67 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 67 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 67 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 67 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 67 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 68 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 68 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 68 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 68 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 12 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 68 13 reservoir reservoir NN work_wtnfwgpzqnfabpwucygbl35wyq 68 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 69 1 Dorsal dorsal NN work_wtnfwgpzqnfabpwucygbl35wyq 69 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 69 3 lateral lateral JJ work_wtnfwgpzqnfabpwucygbl35wyq 69 4 images image NNS work_wtnfwgpzqnfabpwucygbl35wyq 69 5 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 69 6 acquired acquire VBN work_wtnfwgpzqnfabpwucygbl35wyq 69 7 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 69 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 69 9 > > NN work_wtnfwgpzqnfabpwucygbl35wyq 69 10 70 70 CD work_wtnfwgpzqnfabpwucygbl35wyq 69 11 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 69 12 minimum minimum JJ work_wtnfwgpzqnfabpwucygbl35wyq 69 13 similarity similarity NN work_wtnfwgpzqnfabpwucygbl35wyq 69 14 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 69 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 69 16 pattern pattern NN work_wtnfwgpzqnfabpwucygbl35wyq 69 17 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 69 18 recognition recognition NN work_wtnfwgpzqnfabpwucygbl35wyq 69 19 algorithm algorithm NN work_wtnfwgpzqnfabpwucygbl35wyq 69 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 70 1 Once once RB work_wtnfwgpzqnfabpwucygbl35wyq 70 2 recognised recognise VBN work_wtnfwgpzqnfabpwucygbl35wyq 70 3 inside inside IN work_wtnfwgpzqnfabpwucygbl35wyq 70 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 70 5 600 600 CD work_wtnfwgpzqnfabpwucygbl35wyq 70 6 μm μm NN work_wtnfwgpzqnfabpwucygbl35wyq 70 7 capillary capillary JJ work_wtnfwgpzqnfabpwucygbl35wyq 70 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 70 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 70 10 VAST vast JJ work_wtnfwgpzqnfabpwucygbl35wyq 70 11 module module NN work_wtnfwgpzqnfabpwucygbl35wyq 70 12 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 70 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 70 14 microscope microscope NN work_wtnfwgpzqnfabpwucygbl35wyq 70 15 stage stage NN work_wtnfwgpzqnfabpwucygbl35wyq 70 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 70 17 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 70 18 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 70 19 rotated rotate VBN work_wtnfwgpzqnfabpwucygbl35wyq 70 20 180 180 CD work_wtnfwgpzqnfabpwucygbl35wyq 70 21 ° ° NNS work_wtnfwgpzqnfabpwucygbl35wyq 70 22 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 70 23 capture capture VB work_wtnfwgpzqnfabpwucygbl35wyq 70 24 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 70 25 fluorescent fluorescent JJ work_wtnfwgpzqnfabpwucygbl35wyq 70 26 image image NN work_wtnfwgpzqnfabpwucygbl35wyq 70 27 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 70 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 70 29 jaw jaw NN work_wtnfwgpzqnfabpwucygbl35wyq 70 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 71 1 NIH NIH NNP work_wtnfwgpzqnfabpwucygbl35wyq 71 2 ImageJ ImageJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 71 3 software software NN work_wtnfwgpzqnfabpwucygbl35wyq 71 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 71 5 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 71 6 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 71 7 measure measure VB work_wtnfwgpzqnfabpwucygbl35wyq 71 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 71 9 angle angle NN work_wtnfwgpzqnfabpwucygbl35wyq 71 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 71 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 71 12 ceratohyal ceratohyal NN work_wtnfwgpzqnfabpwucygbl35wyq 71 13 cartilage cartilage NN work_wtnfwgpzqnfabpwucygbl35wyq 71 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 72 1 Whole whole JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 2 mount mount NN work_wtnfwgpzqnfabpwucygbl35wyq 72 3 TUNEL TUNEL NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 72 5 immunostaining immunostaine VBG work_wtnfwgpzqnfabpwucygbl35wyq 72 6 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 72 7 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 72 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 72 9 ApopTag ApopTag NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 10 rhodamine rhodamine NN work_wtnfwgpzqnfabpwucygbl35wyq 72 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 72 12 situ situ JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 13 Apoptosis Apoptosis NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 14 Detection Detection NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 15 kit kit NN work_wtnfwgpzqnfabpwucygbl35wyq 72 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 17 Chemicon Chemicon NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 19 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 72 20 described.16 described.16 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 21 17 17 CD work_wtnfwgpzqnfabpwucygbl35wyq 72 22 For for IN work_wtnfwgpzqnfabpwucygbl35wyq 72 23 whole whole JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 24 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 72 25 mount mount NN work_wtnfwgpzqnfabpwucygbl35wyq 72 26 immunostain- immunostain- NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 27 ing ing NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 29 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 72 30 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 72 31 fixed fix VBN work_wtnfwgpzqnfabpwucygbl35wyq 72 32 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 72 33 Dent Dent NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 34 ’s ’s NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 35 solution solution NN work_wtnfwgpzqnfabpwucygbl35wyq 72 36 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 72 37 stained stain VBN work_wtnfwgpzqnfabpwucygbl35wyq 72 38 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 72 39 primary primary JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 40 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 72 41 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 42 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 43 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 44 phospho phospho JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 45 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 72 46 histone histone NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 47 H3 H3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 48 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 49 ser10)-R ser10)-R NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 50 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 72 51 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 52 sc-8656-R sc-8656-R NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 53 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 54 Santa Santa NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 55 Cruz Cruz NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 56 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 57 1:500 1:500 CD work_wtnfwgpzqnfabpwucygbl35wyq 72 58 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 59 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 72 60 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 61 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 62 acetylated acetylated JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 63 tubulin tubulin NN work_wtnfwgpzqnfabpwucygbl35wyq 72 64 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 65 T7451 T7451 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 66 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 67 Sigma Sigma NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 68 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 72 69 Aldrich Aldrich NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 70 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 71 1:1000 1:1000 CD work_wtnfwgpzqnfabpwucygbl35wyq 72 72 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 73 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 72 74 anti anti NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 75 - - NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 76 NaK NaK NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 77 ATPase ATPase NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 78 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 79 a6F a6F NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 80 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 81 DSHB;1:500 DSHB;1:500 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 82 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 83 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 84 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 72 85 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 72 86 secondary secondary JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 87 detection detection NN work_wtnfwgpzqnfabpwucygbl35wyq 72 88 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 72 89 accomplished accomplish VBN work_wtnfwgpzqnfabpwucygbl35wyq 72 90 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 72 91 Alexa Alexa NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 92 Fluor Fluor NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 93 goat goat NN work_wtnfwgpzqnfabpwucygbl35wyq 72 94 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 95 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 96 mouse mouse JJ work_wtnfwgpzqnfabpwucygbl35wyq 72 97 IgG IgG NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 98 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 99 A21207 A21207 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 100 , , , work_wtnfwgpzqnfabpwucygbl35wyq 72 101 Invitrogen Invitrogen NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 102 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 72 103 1:1000 1:1000 LS work_wtnfwgpzqnfabpwucygbl35wyq 72 104 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 72 105 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 72 106 blocking block VBG work_wtnfwgpzqnfabpwucygbl35wyq 72 107 solution solution NN work_wtnfwgpzqnfabpwucygbl35wyq 72 108 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 72 109 described.16 described.16 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 110 18 18 CD work_wtnfwgpzqnfabpwucygbl35wyq 72 111 19 19 CD work_wtnfwgpzqnfabpwucygbl35wyq 72 112 Fluorescent Fluorescent NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 113 signals signal NNS work_wtnfwgpzqnfabpwucygbl35wyq 72 114 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 72 115 imaged image VBN work_wtnfwgpzqnfabpwucygbl35wyq 72 116 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 72 117 laterally laterally RB work_wtnfwgpzqnfabpwucygbl35wyq 72 118 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 72 119 ventrally ventrally RB work_wtnfwgpzqnfabpwucygbl35wyq 72 120 positioned position VBN work_wtnfwgpzqnfabpwucygbl35wyq 72 121 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 122 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 72 123 z z NN work_wtnfwgpzqnfabpwucygbl35wyq 72 124 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 72 125 stacked stack VBN work_wtnfwgpzqnfabpwucygbl35wyq 72 126 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 72 127 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 72 128 Nikon Nikon NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 129 AZ100 AZ100 NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 130 microscope microscope NN work_wtnfwgpzqnfabpwucygbl35wyq 72 131 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 72 132 NIS NIS NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 133 Elements Elements NNPS work_wtnfwgpzqnfabpwucygbl35wyq 72 134 AR AR NNP work_wtnfwgpzqnfabpwucygbl35wyq 72 135 software software NN work_wtnfwgpzqnfabpwucygbl35wyq 72 136 . . . work_wtnfwgpzqnfabpwucygbl35wyq 73 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 73 2 quantified quantify VBD work_wtnfwgpzqnfabpwucygbl35wyq 73 3 staining stain VBG work_wtnfwgpzqnfabpwucygbl35wyq 73 4 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 73 5 counting count VBG work_wtnfwgpzqnfabpwucygbl35wyq 73 6 positive positive JJ work_wtnfwgpzqnfabpwucygbl35wyq 73 7 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 73 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 73 9 defined defined JJ work_wtnfwgpzqnfabpwucygbl35wyq 73 10 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 73 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 73 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 73 13 head head NN work_wtnfwgpzqnfabpwucygbl35wyq 73 14 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 73 15 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 73 16 ImageJ ImageJ NNPS work_wtnfwgpzqnfabpwucygbl35wyq 73 17 software software NN work_wtnfwgpzqnfabpwucygbl35wyq 73 18 ; ; , work_wtnfwgpzqnfabpwucygbl35wyq 73 19 positive positive JJ work_wtnfwgpzqnfabpwucygbl35wyq 73 20 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 73 21 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 73 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 73 23 eyes eye NNS work_wtnfwgpzqnfabpwucygbl35wyq 73 24 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 73 25 removed remove VBN work_wtnfwgpzqnfabpwucygbl35wyq 73 26 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 73 27 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 73 28 counts count NNS work_wtnfwgpzqnfabpwucygbl35wyq 73 29 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 73 30 TUNEL TUNEL NNP work_wtnfwgpzqnfabpwucygbl35wyq 73 31 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 73 32 phospho phospho NN work_wtnfwgpzqnfabpwucygbl35wyq 73 33 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 73 34 histone histone NNP work_wtnfwgpzqnfabpwucygbl35wyq 73 35 H3 H3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 73 36 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 73 37 . . . work_wtnfwgpzqnfabpwucygbl35wyq 74 1 NIH NIH NNP work_wtnfwgpzqnfabpwucygbl35wyq 74 2 ImageJ ImageJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 74 3 software software NN work_wtnfwgpzqnfabpwucygbl35wyq 74 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 74 5 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 74 6 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 74 7 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 74 8 measure measure VB work_wtnfwgpzqnfabpwucygbl35wyq 74 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 74 10 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 74 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 74 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 74 13 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 74 14 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 74 15 convolution convolution NN work_wtnfwgpzqnfabpwucygbl35wyq 74 16 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 74 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 74 18 cere- cere- NN work_wtnfwgpzqnfabpwucygbl35wyq 74 19 bellum bellum NN work_wtnfwgpzqnfabpwucygbl35wyq 74 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 75 1 Data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 75 2 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 75 3 analysed analyse VBN work_wtnfwgpzqnfabpwucygbl35wyq 75 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 75 5 graphed graph VBN work_wtnfwgpzqnfabpwucygbl35wyq 75 6 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 75 7 GraphPad GraphPad NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 8 Prism Prism NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 9 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 75 10 software software NN work_wtnfwgpzqnfabpwucygbl35wyq 75 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 75 12 GraphPad GraphPad NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 75 14 San San NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 15 Diego Diego NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 75 17 California California NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 75 19 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 75 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 75 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 76 1 Holm Holm NNP work_wtnfwgpzqnfabpwucygbl35wyq 76 2 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 76 3 Šídák Šídák NNP work_wtnfwgpzqnfabpwucygbl35wyq 76 4 multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 76 5 comparison comparison NN work_wtnfwgpzqnfabpwucygbl35wyq 76 6 testing testing NN work_wtnfwgpzqnfabpwucygbl35wyq 76 7 following follow VBG work_wtnfwgpzqnfabpwucygbl35wyq 76 8 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 76 9 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 76 10 way way NN work_wtnfwgpzqnfabpwucygbl35wyq 76 11 ana- ana- NN work_wtnfwgpzqnfabpwucygbl35wyq 76 12 lysis lysis NN work_wtnfwgpzqnfabpwucygbl35wyq 76 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 76 14 variance variance NN work_wtnfwgpzqnfabpwucygbl35wyq 76 15 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 76 16 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 76 17 separately separately RB work_wtnfwgpzqnfabpwucygbl35wyq 76 18 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 76 19 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 76 20 set set NN work_wtnfwgpzqnfabpwucygbl35wyq 76 21 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 76 22 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 76 23 corresponding correspond VBG work_wtnfwgpzqnfabpwucygbl35wyq 76 24 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 76 25 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 76 26 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 76 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 77 1 p p LS work_wtnfwgpzqnfabpwucygbl35wyq 77 2 Values value NNS work_wtnfwgpzqnfabpwucygbl35wyq 77 3 less less JJR work_wtnfwgpzqnfabpwucygbl35wyq 77 4 than than IN work_wtnfwgpzqnfabpwucygbl35wyq 77 5 0.05 0.05 CD work_wtnfwgpzqnfabpwucygbl35wyq 77 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 77 7 0.01 0.01 CD work_wtnfwgpzqnfabpwucygbl35wyq 77 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 77 9 0.001 0.001 CD work_wtnfwgpzqnfabpwucygbl35wyq 77 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 77 11 0.0001 0.0001 CD work_wtnfwgpzqnfabpwucygbl35wyq 77 12 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 77 13 summarised summarise VBN work_wtnfwgpzqnfabpwucygbl35wyq 77 14 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 77 15 * * NN work_wtnfwgpzqnfabpwucygbl35wyq 77 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 77 17 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 18 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 77 20 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 21 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 22 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 23 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 77 24 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 25 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 26 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 27 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 77 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 77 29 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 77 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 78 1 p p LS work_wtnfwgpzqnfabpwucygbl35wyq 78 2 Values value NNS work_wtnfwgpzqnfabpwucygbl35wyq 78 3 > > XX work_wtnfwgpzqnfabpwucygbl35wyq 78 4 0.05 0.05 CD work_wtnfwgpzqnfabpwucygbl35wyq 78 5 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 78 6 indicated indicate VBN work_wtnfwgpzqnfabpwucygbl35wyq 78 7 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 78 8 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 78 9 ns ns NNP work_wtnfwgpzqnfabpwucygbl35wyq 78 10 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 78 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 78 12 non non JJ work_wtnfwgpzqnfabpwucygbl35wyq 78 13 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 78 14 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 78 15 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 78 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 79 1 Molecular molecular JJ work_wtnfwgpzqnfabpwucygbl35wyq 79 2 cloning cloning NN work_wtnfwgpzqnfabpwucygbl35wyq 79 3 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 79 4 site site NN work_wtnfwgpzqnfabpwucygbl35wyq 79 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 79 6 directed direct VBN work_wtnfwgpzqnfabpwucygbl35wyq 79 7 mutagenesis mutagenesis NN work_wtnfwgpzqnfabpwucygbl35wyq 79 8 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 79 9 obtained obtain VBD work_wtnfwgpzqnfabpwucygbl35wyq 79 10 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 79 11 Gateway Gateway NNP work_wtnfwgpzqnfabpwucygbl35wyq 79 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 79 13 adapted adapt VBN work_wtnfwgpzqnfabpwucygbl35wyq 79 14 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 79 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 79 16 length length NN work_wtnfwgpzqnfabpwucygbl35wyq 79 17 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 79 18 open open JJ work_wtnfwgpzqnfabpwucygbl35wyq 79 19 reading reading NN work_wtnfwgpzqnfabpwucygbl35wyq 79 20 frame frame NN work_wtnfwgpzqnfabpwucygbl35wyq 79 21 entry entry NN work_wtnfwgpzqnfabpwucygbl35wyq 79 22 clone clone NN work_wtnfwgpzqnfabpwucygbl35wyq 79 23 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 79 24 Invitrogen Invitrogen NNP work_wtnfwgpzqnfabpwucygbl35wyq 79 25 clone clone NN work_wtnfwgpzqnfabpwucygbl35wyq 79 26 IOH56860 IOH56860 NNP work_wtnfwgpzqnfabpwucygbl35wyq 79 27 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 79 28 NM_018131.4 NM_018131.4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 79 29 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 79 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 80 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 80 2 conducted conduct VBD work_wtnfwgpzqnfabpwucygbl35wyq 80 3 site site NN work_wtnfwgpzqnfabpwucygbl35wyq 80 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 80 5 directed direct VBN work_wtnfwgpzqnfabpwucygbl35wyq 80 6 mutagenesis mutagenesis NN work_wtnfwgpzqnfabpwucygbl35wyq 80 7 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 80 8 insert insert VB work_wtnfwgpzqnfabpwucygbl35wyq 80 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 80 10 c.171C c.171C NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 11 > > XX work_wtnfwgpzqnfabpwucygbl35wyq 80 12 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 80 14 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 80 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 80 16 H57Q h57q NN work_wtnfwgpzqnfabpwucygbl35wyq 80 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 80 18 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 80 19 c.1133A c.1133a ADD work_wtnfwgpzqnfabpwucygbl35wyq 80 20 > > NFP work_wtnfwgpzqnfabpwucygbl35wyq 80 21 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 80 23 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 80 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 80 25 H378L H378L NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 80 27 var- var- NN work_wtnfwgpzqnfabpwucygbl35wyq 80 28 iants iant NNS work_wtnfwgpzqnfabpwucygbl35wyq 80 29 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 80 30 described.20 described.20 NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 31 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 80 32 c.1274C c.1274c XX work_wtnfwgpzqnfabpwucygbl35wyq 80 33 > > NFP work_wtnfwgpzqnfabpwucygbl35wyq 80 34 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 80 35 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 80 36 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 80 37 . . . work_wtnfwgpzqnfabpwucygbl35wyq 80 38 S425X s425x LS work_wtnfwgpzqnfabpwucygbl35wyq 80 39 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 80 40 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 80 41 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 80 42 introduced introduce VBN work_wtnfwgpzqnfabpwucygbl35wyq 80 43 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 80 44 NorClone NorClone NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 45 Biotech Biotech NNP work_wtnfwgpzqnfabpwucygbl35wyq 80 46 . . . work_wtnfwgpzqnfabpwucygbl35wyq 81 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 81 2 integrity integrity NN work_wtnfwgpzqnfabpwucygbl35wyq 81 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 81 4 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 81 5 clones clone NNS work_wtnfwgpzqnfabpwucygbl35wyq 81 6 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 81 7 confirmed confirm VBN work_wtnfwgpzqnfabpwucygbl35wyq 81 8 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 81 9 restriction restriction NN work_wtnfwgpzqnfabpwucygbl35wyq 81 10 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 81 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 81 12 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 81 13 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 81 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 82 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 82 2 Gateway Gateway NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 3 system system NN work_wtnfwgpzqnfabpwucygbl35wyq 82 4 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 5 Life Life NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 6 Technologies Technologies NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 7 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 8 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 82 9 used use VBN work_wtnfwgpzqnfabpwucygbl35wyq 82 10 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 82 11 generate generate VB work_wtnfwgpzqnfabpwucygbl35wyq 82 12 either either CC work_wtnfwgpzqnfabpwucygbl35wyq 82 13 monomeric monomeric JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 14 Red Red NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 15 Fluorescent Fluorescent NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 16 Protein Protein NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 18 mRFP)-tagged mrfp)-tagge VBN work_wtnfwgpzqnfabpwucygbl35wyq 82 19 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 20 constructs construct NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 22 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 23 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 82 24 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 82 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 26 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 28 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 82 29 mutant mutant NN work_wtnfwgpzqnfabpwucygbl35wyq 82 30 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 31 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 82 32 pDest-733 pDest-733 NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 33 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 82 34 N n CD work_wtnfwgpzqnfabpwucygbl35wyq 82 35 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 82 36 terminal terminal JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 37 fusion fusion NN work_wtnfwgpzqnfabpwucygbl35wyq 82 38 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 82 39 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 40 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 41 protein protein NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 42 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 82 43 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 44 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 45 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 82 46 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 82 47 template template VB work_wtnfwgpzqnfabpwucygbl35wyq 82 48 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 82 49 SP6 SP6 NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 50 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 82 51 vitro vitro FW work_wtnfwgpzqnfabpwucygbl35wyq 82 52 transcription transcription NN work_wtnfwgpzqnfabpwucygbl35wyq 82 53 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 82 54 pCS2 pcs2 NN work_wtnfwgpzqnfabpwucygbl35wyq 82 55 + + NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 56 -dest -dest : work_wtnfwgpzqnfabpwucygbl35wyq 82 57 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 58 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 59 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 82 60 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 82 61 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 62 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 63 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 64 according accord VBG work_wtnfwgpzqnfabpwucygbl35wyq 82 65 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 82 66 standard standard JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 67 protocols.21 protocols.21 NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 68 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 69 culture culture NN work_wtnfwgpzqnfabpwucygbl35wyq 82 70 , , , work_wtnfwgpzqnfabpwucygbl35wyq 82 71 transfections transfection NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 72 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 82 73 subcellular subcellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 74 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 82 75 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 76 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 77 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 78 CRL-1651 CRL-1651 NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 79 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 82 80 ATCC ATCC NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 81 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 82 , , , work_wtnfwgpzqnfabpwucygbl35wyq 82 83 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 84 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 82 85 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 82 86 healthy healthy JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 87 individual individual NN work_wtnfwgpzqnfabpwucygbl35wyq 82 88 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 89 3348)22 3348)22 UH work_wtnfwgpzqnfabpwucygbl35wyq 82 90 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 82 91 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 92 derived derive VBN work_wtnfwgpzqnfabpwucygbl35wyq 82 93 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 82 94 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 82 95 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 82 96 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 82 97 grown grow VBN work_wtnfwgpzqnfabpwucygbl35wyq 82 98 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 82 99 Dulbecco Dulbecco NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 100 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 82 101 modified modify VBN work_wtnfwgpzqnfabpwucygbl35wyq 82 102 Eagle Eagle NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 103 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 82 104 medium medium NN work_wtnfwgpzqnfabpwucygbl35wyq 82 105 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 106 Gibco Gibco NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 107 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 108 supplemented supplement VBD work_wtnfwgpzqnfabpwucygbl35wyq 82 109 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 82 110 10 10 CD work_wtnfwgpzqnfabpwucygbl35wyq 82 111 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 82 112 fetal fetal JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 113 bovine bovine NN work_wtnfwgpzqnfabpwucygbl35wyq 82 114 serum serum NN work_wtnfwgpzqnfabpwucygbl35wyq 82 115 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 116 Gibco Gibco NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 117 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 118 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 82 119 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 82 120 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 82 121 antibiotic antibiotic JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 122 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 82 123 antimycotic antimycotic JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 124 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 125 Gibco Gibco NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 126 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 82 127 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 82 128 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 82 129 humidified humidified JJ work_wtnfwgpzqnfabpwucygbl35wyq 82 130 37 37 CD work_wtnfwgpzqnfabpwucygbl35wyq 82 131 ° ° NNS work_wtnfwgpzqnfabpwucygbl35wyq 82 132 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 133 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 82 134 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 82 135 CO2 CO2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 82 136 incubator incubator NN work_wtnfwgpzqnfabpwucygbl35wyq 82 137 . . . work_wtnfwgpzqnfabpwucygbl35wyq 83 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 83 2 seeded seed VBD work_wtnfwgpzqnfabpwucygbl35wyq 83 3 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 4 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 83 5 50–80 50–80 CD work_wtnfwgpzqnfabpwucygbl35wyq 83 6 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 83 7 confluence confluence NN work_wtnfwgpzqnfabpwucygbl35wyq 83 8 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 83 9 sterile sterile JJ work_wtnfwgpzqnfabpwucygbl35wyq 83 10 glass glass NN work_wtnfwgpzqnfabpwucygbl35wyq 83 11 cover cover NN work_wtnfwgpzqnfabpwucygbl35wyq 83 12 slips slip VBZ work_wtnfwgpzqnfabpwucygbl35wyq 83 13 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 83 14 6-well 6-well CD work_wtnfwgpzqnfabpwucygbl35wyq 83 15 plates plate NNS work_wtnfwgpzqnfabpwucygbl35wyq 83 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 83 17 incubated incubate VBD work_wtnfwgpzqnfabpwucygbl35wyq 83 18 them -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 83 19 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 83 20 24 24 CD work_wtnfwgpzqnfabpwucygbl35wyq 83 21 hours hour NNS work_wtnfwgpzqnfabpwucygbl35wyq 83 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 83 23 transfected transfecte VBN work_wtnfwgpzqnfabpwucygbl35wyq 83 24 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 83 25 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 83 26 μg μg DT work_wtnfwgpzqnfabpwucygbl35wyq 83 27 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 83 28 plasmid plasmid NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 29 DNA DNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 30 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 83 31 48 48 CD work_wtnfwgpzqnfabpwucygbl35wyq 83 32 hours hour NNS work_wtnfwgpzqnfabpwucygbl35wyq 83 33 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 83 34 Effectene Effectene NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 35 Transfection Transfection NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 36 Kit Kit NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 37 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 83 38 QIAGEN qiagen NN work_wtnfwgpzqnfabpwucygbl35wyq 83 39 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 83 40 according accord VBG work_wtnfwgpzqnfabpwucygbl35wyq 83 41 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 83 42 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 83 43 manufac- manufac- NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 44 turer turer NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 45 ’s ’s NNP work_wtnfwgpzqnfabpwucygbl35wyq 83 46 instructions instruction NNS work_wtnfwgpzqnfabpwucygbl35wyq 83 47 . . . work_wtnfwgpzqnfabpwucygbl35wyq 84 1 Cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 84 2 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 84 3 fixed fix VBN work_wtnfwgpzqnfabpwucygbl35wyq 84 4 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 84 5 3.7 3.7 CD work_wtnfwgpzqnfabpwucygbl35wyq 84 6 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 84 7 paraformaldehyde paraformaldehyde NN work_wtnfwgpzqnfabpwucygbl35wyq 84 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 84 9 phosphate phosphate JJ work_wtnfwgpzqnfabpwucygbl35wyq 84 10 buffered buffered JJ work_wtnfwgpzqnfabpwucygbl35wyq 84 11 saline saline NN work_wtnfwgpzqnfabpwucygbl35wyq 84 12 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 84 13 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 14 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 84 15 Gibco Gibco NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 84 17 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 84 18 20 20 CD work_wtnfwgpzqnfabpwucygbl35wyq 84 19 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 84 20 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 84 21 room room NN work_wtnfwgpzqnfabpwucygbl35wyq 84 22 temperature temperature NN work_wtnfwgpzqnfabpwucygbl35wyq 84 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 84 24 washed wash VBD work_wtnfwgpzqnfabpwucygbl35wyq 84 25 twice twice RB work_wtnfwgpzqnfabpwucygbl35wyq 84 26 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 84 27 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 84 29 incubated incubate VBD work_wtnfwgpzqnfabpwucygbl35wyq 84 30 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 84 31 0.2 0.2 CD work_wtnfwgpzqnfabpwucygbl35wyq 84 32 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 84 33 Triton Triton NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 34 X-100 X-100 NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 35 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 84 36 Sigma Sigma NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 37 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 84 38 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 84 39 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 84 40 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 84 41 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 84 42 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 84 43 . . . work_wtnfwgpzqnfabpwucygbl35wyq 85 1 Slides slide NNS work_wtnfwgpzqnfabpwucygbl35wyq 85 2 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 85 3 blocked block VBN work_wtnfwgpzqnfabpwucygbl35wyq 85 4 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 85 5 20 20 CD work_wtnfwgpzqnfabpwucygbl35wyq 85 6 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 85 7 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 85 8 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 85 9 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 85 10 bovine bovine NN work_wtnfwgpzqnfabpwucygbl35wyq 85 11 serum serum NN work_wtnfwgpzqnfabpwucygbl35wyq 85 12 albumin albumin NN work_wtnfwgpzqnfabpwucygbl35wyq 85 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 85 14 BSA BSA NNP work_wtnfwgpzqnfabpwucygbl35wyq 85 15 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 85 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 85 17 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 85 18 before before IN work_wtnfwgpzqnfabpwucygbl35wyq 85 19 both both CC work_wtnfwgpzqnfabpwucygbl35wyq 85 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 85 21 primary primary JJ work_wtnfwgpzqnfabpwucygbl35wyq 85 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 85 23 secondary secondary JJ work_wtnfwgpzqnfabpwucygbl35wyq 85 24 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 85 25 incubation incubation NN work_wtnfwgpzqnfabpwucygbl35wyq 85 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 86 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 86 2 incu- incu- VBD work_wtnfwgpzqnfabpwucygbl35wyq 86 3 bated bate VBN work_wtnfwgpzqnfabpwucygbl35wyq 86 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 86 5 slides slide NNS work_wtnfwgpzqnfabpwucygbl35wyq 86 6 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 86 7 primary primary JJ work_wtnfwgpzqnfabpwucygbl35wyq 86 8 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 86 9 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 86 10 α α JJ work_wtnfwgpzqnfabpwucygbl35wyq 86 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 86 12 tubulin tubulin NN work_wtnfwgpzqnfabpwucygbl35wyq 86 13 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 86 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 86 15 rat rat NNP work_wtnfwgpzqnfabpwucygbl35wyq 86 16 mono- mono- NNP work_wtnfwgpzqnfabpwucygbl35wyq 86 17 clonal clonal JJ work_wtnfwgpzqnfabpwucygbl35wyq 86 18 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 86 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 86 20 MCA77 MCA77 NNP work_wtnfwgpzqnfabpwucygbl35wyq 86 21 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 86 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 86 23 Cedarlane cedarlane NN work_wtnfwgpzqnfabpwucygbl35wyq 86 24 ; ; , work_wtnfwgpzqnfabpwucygbl35wyq 86 25 1:2000 1:2000 CD work_wtnfwgpzqnfabpwucygbl35wyq 86 26 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 86 27 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 86 28 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 86 29 BSA BSA NNP work_wtnfwgpzqnfabpwucygbl35wyq 86 30 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 86 31 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 86 32 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 86 33 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 86 34 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 86 35 hour hour NN work_wtnfwgpzqnfabpwucygbl35wyq 86 36 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 86 37 room room NN work_wtnfwgpzqnfabpwucygbl35wyq 86 38 temperature temperature NN work_wtnfwgpzqnfabpwucygbl35wyq 86 39 . . . work_wtnfwgpzqnfabpwucygbl35wyq 87 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 87 2 then then RB work_wtnfwgpzqnfabpwucygbl35wyq 87 3 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 87 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 87 5 goat goat NN work_wtnfwgpzqnfabpwucygbl35wyq 87 6 α α NNP work_wtnfwgpzqnfabpwucygbl35wyq 87 7 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 87 8 Rat rat NN work_wtnfwgpzqnfabpwucygbl35wyq 87 9 IgG IgG NNP work_wtnfwgpzqnfabpwucygbl35wyq 87 10 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 87 11 H+L H+L NNP work_wtnfwgpzqnfabpwucygbl35wyq 87 12 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 87 13 Alexa Alexa NNP work_wtnfwgpzqnfabpwucygbl35wyq 87 14 488 488 CD work_wtnfwgpzqnfabpwucygbl35wyq 87 15 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 87 16 diluted dilute VBN work_wtnfwgpzqnfabpwucygbl35wyq 87 17 1:300 1:300 CD work_wtnfwgpzqnfabpwucygbl35wyq 87 18 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 87 19 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 87 20 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 87 21 BSA BSA NNP work_wtnfwgpzqnfabpwucygbl35wyq 87 22 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 87 23 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 87 24 incubated incubate VBD work_wtnfwgpzqnfabpwucygbl35wyq 87 25 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 87 26 room room NN work_wtnfwgpzqnfabpwucygbl35wyq 87 27 temperature temperature NN work_wtnfwgpzqnfabpwucygbl35wyq 87 28 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 87 29 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 87 30 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 87 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 88 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 88 2 cover- cover- JJ work_wtnfwgpzqnfabpwucygbl35wyq 88 3 slips slip NNS work_wtnfwgpzqnfabpwucygbl35wyq 88 4 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 88 5 washed wash VBN work_wtnfwgpzqnfabpwucygbl35wyq 88 6 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 88 7 times time NNS work_wtnfwgpzqnfabpwucygbl35wyq 88 8 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 88 9 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 88 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 88 11 dipped dip VBN work_wtnfwgpzqnfabpwucygbl35wyq 88 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 88 13 deionised deionise VBN work_wtnfwgpzqnfabpwucygbl35wyq 88 14 water water NN work_wtnfwgpzqnfabpwucygbl35wyq 88 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 88 16 inverted invert VBN work_wtnfwgpzqnfabpwucygbl35wyq 88 17 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 88 18 mounted mount VBN work_wtnfwgpzqnfabpwucygbl35wyq 88 19 onto onto IN work_wtnfwgpzqnfabpwucygbl35wyq 88 20 glass glass NN work_wtnfwgpzqnfabpwucygbl35wyq 88 21 microscope microscope NN work_wtnfwgpzqnfabpwucygbl35wyq 88 22 slides slide VBZ work_wtnfwgpzqnfabpwucygbl35wyq 88 23 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 88 24 Vectashield Vectashield NNP work_wtnfwgpzqnfabpwucygbl35wyq 88 25 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 88 26 DAPI DAPI NNP work_wtnfwgpzqnfabpwucygbl35wyq 88 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 88 28 Vector Vector NNP work_wtnfwgpzqnfabpwucygbl35wyq 88 29 Laboratories Laboratories NNP work_wtnfwgpzqnfabpwucygbl35wyq 88 30 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 88 31 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 88 32 sealed seal VBN work_wtnfwgpzqnfabpwucygbl35wyq 88 33 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 88 34 nail nail NN work_wtnfwgpzqnfabpwucygbl35wyq 88 35 polish polish NN work_wtnfwgpzqnfabpwucygbl35wyq 88 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 89 1 Microscopic microscopic JJ work_wtnfwgpzqnfabpwucygbl35wyq 89 2 imaging imaging NN work_wtnfwgpzqnfabpwucygbl35wyq 89 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 89 4 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 89 5 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 89 6 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 89 7 Olympus Olympus NNP work_wtnfwgpzqnfabpwucygbl35wyq 89 8 BX51 BX51 NNP work_wtnfwgpzqnfabpwucygbl35wyq 89 9 fluorescent fluorescent NN work_wtnfwgpzqnfabpwucygbl35wyq 89 10 microscope microscope NN work_wtnfwgpzqnfabpwucygbl35wyq 89 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 89 12 Olympus Olympus NNP work_wtnfwgpzqnfabpwucygbl35wyq 89 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 89 14 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 89 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 89 16 ON ON NNP work_wtnfwgpzqnfabpwucygbl35wyq 89 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 89 18 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 89 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 89 20 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 89 21 60× 60× CD work_wtnfwgpzqnfabpwucygbl35wyq 89 22 magnification magnification NN work_wtnfwgpzqnfabpwucygbl35wyq 89 23 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 89 24 comparable comparable JJ work_wtnfwgpzqnfabpwucygbl35wyq 89 25 exposure exposure NN work_wtnfwgpzqnfabpwucygbl35wyq 89 26 times time NNS work_wtnfwgpzqnfabpwucygbl35wyq 89 27 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 89 28 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 89 29 experiment experiment NN work_wtnfwgpzqnfabpwucygbl35wyq 89 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 90 1 Images image NNS work_wtnfwgpzqnfabpwucygbl35wyq 90 2 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 90 3 recorded record VBN work_wtnfwgpzqnfabpwucygbl35wyq 90 4 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 90 5 Northern Northern NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 6 Eclipse Eclipse NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 7 soft- soft- NN work_wtnfwgpzqnfabpwucygbl35wyq 90 8 ware ware NN work_wtnfwgpzqnfabpwucygbl35wyq 90 9 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 90 10 Empix Empix NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 90 12 ON ON NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 90 14 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 15 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 90 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 90 17 processed process VBN work_wtnfwgpzqnfabpwucygbl35wyq 90 18 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 90 19 Photoshop Photoshop NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 20 CS3 CS3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 90 22 Illustrator Illustrator NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 23 CS3 CS3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 90 25 Adobe Adobe NNP work_wtnfwgpzqnfabpwucygbl35wyq 90 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 90 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 91 1 Western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 91 2 blotting blot VBG work_wtnfwgpzqnfabpwucygbl35wyq 91 3 48-hours 48-hours CD work_wtnfwgpzqnfabpwucygbl35wyq 91 4 post post NN work_wtnfwgpzqnfabpwucygbl35wyq 91 5 transfection transfection NN work_wtnfwgpzqnfabpwucygbl35wyq 91 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 91 7 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 91 8 lysates lysate NNS work_wtnfwgpzqnfabpwucygbl35wyq 91 9 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 91 10 harvested harvest VBN work_wtnfwgpzqnfabpwucygbl35wyq 91 11 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 91 12 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 91 13 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 91 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 92 1 After after IN work_wtnfwgpzqnfabpwucygbl35wyq 92 2 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 92 3 brief brief JJ work_wtnfwgpzqnfabpwucygbl35wyq 92 4 wash wash NN work_wtnfwgpzqnfabpwucygbl35wyq 92 5 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 92 6 PBS PBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 7 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 92 8 pH pH NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 9 7.4 7.4 CD work_wtnfwgpzqnfabpwucygbl35wyq 92 10 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 92 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 92 12 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 92 13 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 92 14 harvested harvest VBN work_wtnfwgpzqnfabpwucygbl35wyq 92 15 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 92 16 hot hot JJ work_wtnfwgpzqnfabpwucygbl35wyq 92 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 92 18 95 95 CD work_wtnfwgpzqnfabpwucygbl35wyq 92 19 ° ° , work_wtnfwgpzqnfabpwucygbl35wyq 92 20 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 21 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 92 22 1×SDS 1×SDS NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 23 sample sample NN work_wtnfwgpzqnfabpwucygbl35wyq 92 24 buffer buffer NN work_wtnfwgpzqnfabpwucygbl35wyq 92 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 92 26 50 50 CD work_wtnfwgpzqnfabpwucygbl35wyq 92 27 mM mM NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 28 Tris Tris NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 29 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 92 30 HCl HCl NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 92 32 pH pH NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 33 6.8 6.8 CD work_wtnfwgpzqnfabpwucygbl35wyq 92 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 92 35 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 92 36 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 92 37 SDS sds NN work_wtnfwgpzqnfabpwucygbl35wyq 92 38 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 92 39 10 10 CD work_wtnfwgpzqnfabpwucygbl35wyq 92 40 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 92 41 Glycerol Glycerol NNP work_wtnfwgpzqnfabpwucygbl35wyq 92 42 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 92 43 . . . work_wtnfwgpzqnfabpwucygbl35wyq 93 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 93 2 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 93 3 QIAshredder QIAshredder NNP work_wtnfwgpzqnfabpwucygbl35wyq 93 4 columns column NNS work_wtnfwgpzqnfabpwucygbl35wyq 93 5 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 93 6 Qiagen Qiagen NNP work_wtnfwgpzqnfabpwucygbl35wyq 93 7 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 93 8 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 93 9 homogenise homogenise VB work_wtnfwgpzqnfabpwucygbl35wyq 93 10 samples sample NNS work_wtnfwgpzqnfabpwucygbl35wyq 93 11 accord- accord- NNP work_wtnfwgpzqnfabpwucygbl35wyq 93 12 ing e VBG work_wtnfwgpzqnfabpwucygbl35wyq 93 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 93 14 manufacturer manufacturer NN work_wtnfwgpzqnfabpwucygbl35wyq 93 15 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 93 16 instructions instruction NNS work_wtnfwgpzqnfabpwucygbl35wyq 93 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 94 1 Subsequently subsequently RB work_wtnfwgpzqnfabpwucygbl35wyq 94 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 94 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 94 4 added add VBD work_wtnfwgpzqnfabpwucygbl35wyq 94 5 reducing reduce VBG work_wtnfwgpzqnfabpwucygbl35wyq 94 6 buffer buffer NN work_wtnfwgpzqnfabpwucygbl35wyq 94 7 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 94 8 2×SDS 2×SDS NNP work_wtnfwgpzqnfabpwucygbl35wyq 94 9 sample sample NN work_wtnfwgpzqnfabpwucygbl35wyq 94 10 buffer buffer NN work_wtnfwgpzqnfabpwucygbl35wyq 94 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 94 12 2-mercaptoethanol 2-mercaptoethanol CD work_wtnfwgpzqnfabpwucygbl35wyq 94 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 94 14 Sigma Sigma NNP work_wtnfwgpzqnfabpwucygbl35wyq 94 15 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 94 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 94 17 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 94 18 1:1 1:1 CD work_wtnfwgpzqnfabpwucygbl35wyq 94 19 ratio ratio NN work_wtnfwgpzqnfabpwucygbl35wyq 94 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 94 21 supplemented supplement VBN work_wtnfwgpzqnfabpwucygbl35wyq 94 22 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 94 23 bromphenol bromphenol NN work_wtnfwgpzqnfabpwucygbl35wyq 94 24 blue blue JJ work_wtnfwgpzqnfabpwucygbl35wyq 94 25 dye dye NN work_wtnfwgpzqnfabpwucygbl35wyq 94 26 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 94 27 Sigma Sigma NNP work_wtnfwgpzqnfabpwucygbl35wyq 94 28 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 94 29 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 94 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 95 1 Samples sample NNS work_wtnfwgpzqnfabpwucygbl35wyq 95 2 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 95 3 heated heat VBN work_wtnfwgpzqnfabpwucygbl35wyq 95 4 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 95 5 95 95 CD work_wtnfwgpzqnfabpwucygbl35wyq 95 6 ° ° , work_wtnfwgpzqnfabpwucygbl35wyq 95 7 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 95 8 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 95 9 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 95 10 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 95 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 95 12 placed place VBN work_wtnfwgpzqnfabpwucygbl35wyq 95 13 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 95 14 ice ice NN work_wtnfwgpzqnfabpwucygbl35wyq 95 15 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 95 16 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 95 17 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 95 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 96 1 40 40 CD work_wtnfwgpzqnfabpwucygbl35wyq 96 2 mg mg NN work_wtnfwgpzqnfabpwucygbl35wyq 96 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 96 4 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 96 5 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 96 6 lysate lysate NN work_wtnfwgpzqnfabpwucygbl35wyq 96 7 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 96 8 analysed analyse VBN work_wtnfwgpzqnfabpwucygbl35wyq 96 9 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 96 10 SDS SDS NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 96 12 PAGE PAGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 96 14 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 96 15 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 96 16 BioRad BioRad NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 17 Mini Mini NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 96 19 Protean Protean NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 20 TGX TGX NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 21 Stain Stain NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 22 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 96 23 Free Free NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 24 Gel Gel NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 25 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 96 26 followed follow VBN work_wtnfwgpzqnfabpwucygbl35wyq 96 27 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 96 28 western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 96 29 blotting blotting NN work_wtnfwgpzqnfabpwucygbl35wyq 96 30 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 96 31 Immobilon Immobilon NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 32 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 96 33 FL FL NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 34 Polyvinylidene Polyvinylidene NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 35 fluoride fluoride NN work_wtnfwgpzqnfabpwucygbl35wyq 96 36 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 96 37 PVDF PVDF NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 38 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 96 39 membranes membrane NNS work_wtnfwgpzqnfabpwucygbl35wyq 96 40 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 96 41 EMD EMD NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 42 Millipore Millipore NNP work_wtnfwgpzqnfabpwucygbl35wyq 96 43 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 96 44 . . . work_wtnfwgpzqnfabpwucygbl35wyq 97 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 97 2 membrane membrane NN work_wtnfwgpzqnfabpwucygbl35wyq 97 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 97 4 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 97 5 incubated incubate VBN work_wtnfwgpzqnfabpwucygbl35wyq 97 6 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 97 7 blocking block VBG work_wtnfwgpzqnfabpwucygbl35wyq 97 8 buffer buffer NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 9 consist- consist- NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 10 ing ing NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 97 12 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 13 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 97 14 milk milk NN work_wtnfwgpzqnfabpwucygbl35wyq 97 15 powder powder NN work_wtnfwgpzqnfabpwucygbl35wyq 97 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 97 17 Tris Tris NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 18 buffered buffer VBN work_wtnfwgpzqnfabpwucygbl35wyq 97 19 saline saline NN work_wtnfwgpzqnfabpwucygbl35wyq 97 20 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 97 21 TBS TBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 97 23 Thermo Thermo NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 24 Scientific Scientific NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 25 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 97 26 without without IN work_wtnfwgpzqnfabpwucygbl35wyq 97 27 Tween-20 tween-20 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 97 29 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 97 30 then then RB work_wtnfwgpzqnfabpwucygbl35wyq 97 31 incubated incubate VBD work_wtnfwgpzqnfabpwucygbl35wyq 97 32 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 97 33 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 97 34 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 97 35 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 36 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 97 37 1:500 1:500 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 38 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 97 39 mouse mouse NN work_wtnfwgpzqnfabpwucygbl35wyq 97 40 polyclonal polyclonal JJ work_wtnfwgpzqnfabpwucygbl35wyq 97 41 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 97 42 raised raise VBD work_wtnfwgpzqnfabpwucygbl35wyq 97 43 against against IN work_wtnfwgpzqnfabpwucygbl35wyq 97 44 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 97 45 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 97 46 length length NN work_wtnfwgpzqnfabpwucygbl35wyq 97 47 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 97 48 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 97 49 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 97 50 H00055165-B01P h00055165-b01p LS work_wtnfwgpzqnfabpwucygbl35wyq 97 51 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 97 52 Abnova Abnova NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 53 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 97 54 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 97 55 blocking block VBG work_wtnfwgpzqnfabpwucygbl35wyq 97 56 buffer buffer NN work_wtnfwgpzqnfabpwucygbl35wyq 97 57 consisting consist VBG work_wtnfwgpzqnfabpwucygbl35wyq 97 58 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 97 59 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 60 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 97 61 milk milk NN work_wtnfwgpzqnfabpwucygbl35wyq 97 62 powder powder NN work_wtnfwgpzqnfabpwucygbl35wyq 97 63 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 97 64 TBS TBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 65 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 97 66 0.1 0.1 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 67 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 97 68 Tween-20 tween-20 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 69 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 97 70 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 97 71 ° ° NNS work_wtnfwgpzqnfabpwucygbl35wyq 97 72 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 97 73 overnight overnight RB work_wtnfwgpzqnfabpwucygbl35wyq 97 74 . . . work_wtnfwgpzqnfabpwucygbl35wyq 98 1 After after IN work_wtnfwgpzqnfabpwucygbl35wyq 98 2 washes wash NNS work_wtnfwgpzqnfabpwucygbl35wyq 98 3 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 98 4 TBS TBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 5 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 98 6 0.1 0.1 CD work_wtnfwgpzqnfabpwucygbl35wyq 98 7 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 98 8 Tween-20 tween-20 CD work_wtnfwgpzqnfabpwucygbl35wyq 98 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 98 10 blots blot NNS work_wtnfwgpzqnfabpwucygbl35wyq 98 11 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 98 12 incubated incubate VBN work_wtnfwgpzqnfabpwucygbl35wyq 98 13 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 98 14 blocking block VBG work_wtnfwgpzqnfabpwucygbl35wyq 98 15 buffer buffer NN work_wtnfwgpzqnfabpwucygbl35wyq 98 16 con- con- NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 17 taining taine VBG work_wtnfwgpzqnfabpwucygbl35wyq 98 18 IRDye IRDye NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 19 800CW 800CW NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 20 Goat Goat NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 21 anti anti NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 22 - - NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 23 Mouse Mouse NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 24 IgG IgG NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 98 26 H+L H+L NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 98 28 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 98 29 1:15 1:15 CD work_wtnfwgpzqnfabpwucygbl35wyq 98 30 000 000 CD work_wtnfwgpzqnfabpwucygbl35wyq 98 31 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 98 32 Mandel Mandel NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 33 Scientific Scientific NNP work_wtnfwgpzqnfabpwucygbl35wyq 98 34 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 98 35 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 98 36 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 98 37 min min NN work_wtnfwgpzqnfabpwucygbl35wyq 98 38 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 98 39 room room NN work_wtnfwgpzqnfabpwucygbl35wyq 98 40 temperature temperature NN work_wtnfwgpzqnfabpwucygbl35wyq 98 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 99 1 Prior prior RB work_wtnfwgpzqnfabpwucygbl35wyq 99 2 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 99 3 imaging imaging NN work_wtnfwgpzqnfabpwucygbl35wyq 99 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 99 5 blots blot NNS work_wtnfwgpzqnfabpwucygbl35wyq 99 6 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 99 7 washed wash VBN work_wtnfwgpzqnfabpwucygbl35wyq 99 8 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 99 9 TBS TBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 99 10 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 99 11 0.1 0.1 CD work_wtnfwgpzqnfabpwucygbl35wyq 99 12 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 99 13 Tween-20 tween-20 CD work_wtnfwgpzqnfabpwucygbl35wyq 99 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 99 15 fol- fol- NN work_wtnfwgpzqnfabpwucygbl35wyq 99 16 lowed low VBN work_wtnfwgpzqnfabpwucygbl35wyq 99 17 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 99 18 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 99 19 5-min 5-min NNP work_wtnfwgpzqnfabpwucygbl35wyq 99 20 incubation incubation NN work_wtnfwgpzqnfabpwucygbl35wyq 99 21 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 99 22 TBS TBS NNP work_wtnfwgpzqnfabpwucygbl35wyq 99 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 100 1 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 2 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 100 3 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 4 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 100 5 bands band NNS work_wtnfwgpzqnfabpwucygbl35wyq 100 6 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 100 7 detected detect VBN work_wtnfwgpzqnfabpwucygbl35wyq 100 8 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 100 9 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 100 10 Odyssey Odyssey NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 11 FC FC NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 12 Imager imager NN work_wtnfwgpzqnfabpwucygbl35wyq 100 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 100 14 Li Li NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 100 16 Cor Cor NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 100 18 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 100 19 imaging imaging NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 20 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 100 21 conducted conduct VBN work_wtnfwgpzqnfabpwucygbl35wyq 100 22 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 100 23 Image Image NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 24 Studio Studio NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 25 V.5.0 V.5.0 NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 26 software software NN work_wtnfwgpzqnfabpwucygbl35wyq 100 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 100 28 Li Li NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 29 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 100 30 Cor Cor NNP work_wtnfwgpzqnfabpwucygbl35wyq 100 31 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 100 32 . . . work_wtnfwgpzqnfabpwucygbl35wyq 101 1 RESULTS RESULTS NNP work_wtnfwgpzqnfabpwucygbl35wyq 101 2 Clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 101 3 features feature VBZ work_wtnfwgpzqnfabpwucygbl35wyq 101 4 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 101 5 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 101 6 visited visit VBD work_wtnfwgpzqnfabpwucygbl35wyq 101 7 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 101 8 genetics genetic NNS work_wtnfwgpzqnfabpwucygbl35wyq 101 9 clinic clinic NN work_wtnfwgpzqnfabpwucygbl35wyq 101 10 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 101 11 their -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 101 12 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 101 13 pregnancy pregnancy NN work_wtnfwgpzqnfabpwucygbl35wyq 101 14 after after IN work_wtnfwgpzqnfabpwucygbl35wyq 101 15 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 101 16 ultrasound ultrasound NN work_wtnfwgpzqnfabpwucygbl35wyq 101 17 examination examination NN work_wtnfwgpzqnfabpwucygbl35wyq 101 18 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 101 19 20 20 CD work_wtnfwgpzqnfabpwucygbl35wyq 101 20 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 101 21 gestation gestation NN work_wtnfwgpzqnfabpwucygbl35wyq 101 22 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 101 23 anhydramnios anhydramnio NNS work_wtnfwgpzqnfabpwucygbl35wyq 101 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 101 25 small small JJ work_wtnfwgpzqnfabpwucygbl35wyq 101 26 dysplastic dysplastic JJ work_wtnfwgpzqnfabpwucygbl35wyq 101 27 kidneys kidney NNS work_wtnfwgpzqnfabpwucygbl35wyq 101 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 101 29 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 101 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 102 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 102 2 mother mother NN work_wtnfwgpzqnfabpwucygbl35wyq 102 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 102 4 25 25 CD work_wtnfwgpzqnfabpwucygbl35wyq 102 5 years year NNS work_wtnfwgpzqnfabpwucygbl35wyq 102 6 old old JJ work_wtnfwgpzqnfabpwucygbl35wyq 102 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 102 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 102 9 antenatal antenatal JJ work_wtnfwgpzqnfabpwucygbl35wyq 102 10 history history NN work_wtnfwgpzqnfabpwucygbl35wyq 102 11 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 102 12 unremarkable unremarkable JJ work_wtnfwgpzqnfabpwucygbl35wyq 102 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 102 14 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 102 15 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 102 16 prenatal prenatal JJ work_wtnfwgpzqnfabpwucygbl35wyq 102 17 screening screening NN work_wtnfwgpzqnfabpwucygbl35wyq 102 18 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 102 19 no no DT work_wtnfwgpzqnfabpwucygbl35wyq 102 20 known know VBN work_wtnfwgpzqnfabpwucygbl35wyq 102 21 teratogenic teratogenic JJ work_wtnfwgpzqnfabpwucygbl35wyq 102 22 exposures exposure NNS work_wtnfwgpzqnfabpwucygbl35wyq 102 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 103 1 Both both DT work_wtnfwgpzqnfabpwucygbl35wyq 103 2 parents parent NNS work_wtnfwgpzqnfabpwucygbl35wyq 103 3 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 103 4 Dutch dutch JJ work_wtnfwgpzqnfabpwucygbl35wyq 103 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 103 6 German german JJ work_wtnfwgpzqnfabpwucygbl35wyq 103 7 Mennonite Mennonite NNP work_wtnfwgpzqnfabpwucygbl35wyq 103 8 ancestry ancestry NN work_wtnfwgpzqnfabpwucygbl35wyq 103 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 103 10 suggesting suggest VBG work_wtnfwgpzqnfabpwucygbl35wyq 103 11 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 103 12 possible possible JJ work_wtnfwgpzqnfabpwucygbl35wyq 103 13 degree degree NN work_wtnfwgpzqnfabpwucygbl35wyq 103 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 103 15 relatedness relatedness NN work_wtnfwgpzqnfabpwucygbl35wyq 103 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 103 17 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 103 18 they -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 103 19 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 103 20 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 103 21 aware aware JJ work_wtnfwgpzqnfabpwucygbl35wyq 103 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 103 23 any any DT work_wtnfwgpzqnfabpwucygbl35wyq 103 24 consanguinity consanguinity NN work_wtnfwgpzqnfabpwucygbl35wyq 103 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 104 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 104 2 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 104 3 history history NN work_wtnfwgpzqnfabpwucygbl35wyq 104 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 104 5 otherwise otherwise RB work_wtnfwgpzqnfabpwucygbl35wyq 104 6 non non JJ work_wtnfwgpzqnfabpwucygbl35wyq 104 7 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 104 8 contributory contributory JJ work_wtnfwgpzqnfabpwucygbl35wyq 104 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 105 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 105 2 fetus fetus NN work_wtnfwgpzqnfabpwucygbl35wyq 105 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 105 4 stillborn stillborn VBN work_wtnfwgpzqnfabpwucygbl35wyq 105 5 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 105 6 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 105 7 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 105 8 gestation gestation NN work_wtnfwgpzqnfabpwucygbl35wyq 105 9 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 105 10 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 105 11 303 303 CD work_wtnfwgpzqnfabpwucygbl35wyq 105 12 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 105 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 106 1 Our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 106 2 fetal fetal JJ work_wtnfwgpzqnfabpwucygbl35wyq 106 3 assessment assessment NN work_wtnfwgpzqnfabpwucygbl35wyq 106 4 unit unit NN work_wtnfwgpzqnfabpwucygbl35wyq 106 5 fol- fol- NN work_wtnfwgpzqnfabpwucygbl35wyq 106 6 lowed low VBD work_wtnfwgpzqnfabpwucygbl35wyq 106 7 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 106 8 subsequent subsequent JJ work_wtnfwgpzqnfabpwucygbl35wyq 106 9 pregnancies pregnancy NNS work_wtnfwgpzqnfabpwucygbl35wyq 106 10 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 106 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 106 12 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 106 13 trimester trimester NN work_wtnfwgpzqnfabpwucygbl35wyq 106 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 107 1 Two two CD work_wtnfwgpzqnfabpwucygbl35wyq 107 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 107 3 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 107 4 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 107 5 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 107 6 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 107 7 found find VBN work_wtnfwgpzqnfabpwucygbl35wyq 107 8 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 107 9 have have VB work_wtnfwgpzqnfabpwucygbl35wyq 107 10 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 107 11 similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 107 12 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 107 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 107 14 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 107 15 fetus fetus NN work_wtnfwgpzqnfabpwucygbl35wyq 107 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 107 17 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 107 18 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 107 19 delivered deliver VBN work_wtnfwgpzqnfabpwucygbl35wyq 107 20 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 107 21 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 107 22 third third JJ work_wtnfwgpzqnfabpwucygbl35wyq 107 23 tri- tri- NNP work_wtnfwgpzqnfabpwucygbl35wyq 107 24 mester mester NN work_wtnfwgpzqnfabpwucygbl35wyq 107 25 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 107 26 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 107 27 male male NN work_wtnfwgpzqnfabpwucygbl35wyq 107 28 died die VBD work_wtnfwgpzqnfabpwucygbl35wyq 107 29 within within IN work_wtnfwgpzqnfabpwucygbl35wyq 107 30 minutes minute NNS work_wtnfwgpzqnfabpwucygbl35wyq 107 31 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 107 32 birth birth NN work_wtnfwgpzqnfabpwucygbl35wyq 107 33 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 107 34 35 35 CD work_wtnfwgpzqnfabpwucygbl35wyq 107 35 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 107 36 ges- ges- VBZ work_wtnfwgpzqnfabpwucygbl35wyq 107 37 tation tation NN work_wtnfwgpzqnfabpwucygbl35wyq 107 38 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 107 39 infant infant NNP work_wtnfwgpzqnfabpwucygbl35wyq 107 40 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 107 41 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 107 42 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 107 43 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 107 44 other other JJ work_wtnfwgpzqnfabpwucygbl35wyq 107 45 male male NN work_wtnfwgpzqnfabpwucygbl35wyq 107 46 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 107 47 stillborn stillborn VBN work_wtnfwgpzqnfabpwucygbl35wyq 107 48 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 107 49 32 32 CD work_wtnfwgpzqnfabpwucygbl35wyq 107 50 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 107 51 gestation gestation NN work_wtnfwgpzqnfabpwucygbl35wyq 107 52 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 107 53 infant infant NNP work_wtnfwgpzqnfabpwucygbl35wyq 107 54 306 306 CD work_wtnfwgpzqnfabpwucygbl35wyq 107 55 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 107 56 . . . work_wtnfwgpzqnfabpwucygbl35wyq 108 1 492 492 CD work_wtnfwgpzqnfabpwucygbl35wyq 108 2 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 108 3   _SP work_wtnfwgpzqnfabpwucygbl35wyq 108 4 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 108 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 108 6 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 108 7   _SP work_wtnfwgpzqnfabpwucygbl35wyq 108 8 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 108 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 109 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 109 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 109 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 109 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 109 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 110 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 110 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 110 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 110 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 110 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 110 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 110 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 110 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 110 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 110 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 110 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 110 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 110 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 110 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 110 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 110 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 110 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 110 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 110 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 110 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 110 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 110 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 110 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 110 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 110 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 110 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 110 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 110 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 110 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 111 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 111 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 111 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 111 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 12 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 13 Postmortem Postmortem NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 14 examination examination NN work_wtnfwgpzqnfabpwucygbl35wyq 111 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 111 16 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 111 17 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 111 18 affected affected JJ work_wtnfwgpzqnfabpwucygbl35wyq 111 19 children child NNS work_wtnfwgpzqnfabpwucygbl35wyq 111 20 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 111 21 evidence evidence NN work_wtnfwgpzqnfabpwucygbl35wyq 111 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 111 23 Potter Potter NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 24 sequence sequence NN work_wtnfwgpzqnfabpwucygbl35wyq 111 25 including include VBG work_wtnfwgpzqnfabpwucygbl35wyq 111 26 microretrognathia microretrognathia NN work_wtnfwgpzqnfabpwucygbl35wyq 111 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 111 28 limb limb NN work_wtnfwgpzqnfabpwucygbl35wyq 111 29 contractures contracture VBZ work_wtnfwgpzqnfabpwucygbl35wyq 111 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 111 31 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 111 32 transverse transverse NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 33 palmar palmar NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 34 creases crease NNS work_wtnfwgpzqnfabpwucygbl35wyq 111 35 , , , work_wtnfwgpzqnfabpwucygbl35wyq 111 36 fifth fifth NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 37 finger finger NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 38 clino- clino- NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 39 dactyly dactyly NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 111 41 talipes talipe NNS work_wtnfwgpzqnfabpwucygbl35wyq 111 42 equinovarus equinovarus NN work_wtnfwgpzqnfabpwucygbl35wyq 111 43 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 111 44 pulmonary pulmonary JJ work_wtnfwgpzqnfabpwucygbl35wyq 111 45 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 111 46 . . . work_wtnfwgpzqnfabpwucygbl35wyq 112 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 112 2 noted note VBD work_wtnfwgpzqnfabpwucygbl35wyq 112 3 additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 4 dysmorphisms dysmorphism NNS work_wtnfwgpzqnfabpwucygbl35wyq 112 5 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 112 6 included include VBD work_wtnfwgpzqnfabpwucygbl35wyq 112 7 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 112 8 pinched pinched JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 9 nose nose NN work_wtnfwgpzqnfabpwucygbl35wyq 112 10 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 112 11 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 112 12 bulbous bulbous JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 13 tip tip NN work_wtnfwgpzqnfabpwucygbl35wyq 112 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 112 15 choanal choanal JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 16 narrowing narrowing NN work_wtnfwgpzqnfabpwucygbl35wyq 112 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 112 18 broad broad JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 19 hands hand NNS work_wtnfwgpzqnfabpwucygbl35wyq 112 20 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 112 21 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 112 22 short short JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 23 fifth fifth JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 24 digit digit NN work_wtnfwgpzqnfabpwucygbl35wyq 112 25 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 112 26 cutaneous cutaneous JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 27 syndactyly syndactyly NNS work_wtnfwgpzqnfabpwucygbl35wyq 112 28 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 112 29 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 112 30 toes toe NNS work_wtnfwgpzqnfabpwucygbl35wyq 112 31 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 112 32 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 112 33 wide wide JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 34 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 35 web web NN work_wtnfwgpzqnfabpwucygbl35wyq 112 36 space space NN work_wtnfwgpzqnfabpwucygbl35wyq 112 37 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 112 38 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 112 39 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 112 40 1A 1a NN work_wtnfwgpzqnfabpwucygbl35wyq 112 41 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 112 42 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 43 supplement supplement NN work_wtnfwgpzqnfabpwucygbl35wyq 112 44 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 112 45 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 112 46 detailed detailed JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 47 pathologic pathologic JJ work_wtnfwgpzqnfabpwucygbl35wyq 112 48 description description NN work_wtnfwgpzqnfabpwucygbl35wyq 112 49 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 112 50 . . . work_wtnfwgpzqnfabpwucygbl35wyq 113 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 113 2 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 113 3 infants infant NNS work_wtnfwgpzqnfabpwucygbl35wyq 113 4 who who WP work_wtnfwgpzqnfabpwucygbl35wyq 113 5 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 113 6 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 7 autopsies autopsy NNS work_wtnfwgpzqnfabpwucygbl35wyq 113 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 113 9 303 303 CD work_wtnfwgpzqnfabpwucygbl35wyq 113 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 113 11 306 306 CD work_wtnfwgpzqnfabpwucygbl35wyq 113 12 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 113 13 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 113 14 dysplastic dysplastic JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 15 aortic aortic JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 16 valves valve NNS work_wtnfwgpzqnfabpwucygbl35wyq 113 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 113 18 dilated dilate VBN work_wtnfwgpzqnfabpwucygbl35wyq 113 19 left left JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 20 ventricles ventricle NNS work_wtnfwgpzqnfabpwucygbl35wyq 113 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 113 22 only only JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 23 vestigial vestigial JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 24 remnants remnant NNS work_wtnfwgpzqnfabpwucygbl35wyq 113 25 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 113 26 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 27 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 113 28 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 113 29 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 113 30 few few JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 31 glomeruli glomeruli NN work_wtnfwgpzqnfabpwucygbl35wyq 113 32 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 113 33 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 113 34 background background NN work_wtnfwgpzqnfabpwucygbl35wyq 113 35 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 113 36 collagenous collagenous JJ work_wtnfwgpzqnfabpwucygbl35wyq 113 37 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 113 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 114 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 114 2 third third JJ work_wtnfwgpzqnfabpwucygbl35wyq 114 3 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 114 4 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 114 5 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 114 6 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 114 7 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 114 8 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 114 9 incomplete incomplete JJ work_wtnfwgpzqnfabpwucygbl35wyq 114 10 autopsy autopsy JJ work_wtnfwgpzqnfabpwucygbl35wyq 114 11 because because IN work_wtnfwgpzqnfabpwucygbl35wyq 114 12 advanced advanced JJ work_wtnfwgpzqnfabpwucygbl35wyq 114 13 autolysis autolysis NN work_wtnfwgpzqnfabpwucygbl35wyq 114 14 compromised compromise VBD work_wtnfwgpzqnfabpwucygbl35wyq 114 15 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 114 16 examination examination NN work_wtnfwgpzqnfabpwucygbl35wyq 114 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 115 1 All all DT work_wtnfwgpzqnfabpwucygbl35wyq 115 2 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 115 3 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 115 4 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 115 5 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 115 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 115 7 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 115 8 head head NN work_wtnfwgpzqnfabpwucygbl35wyq 115 9 size size NN work_wtnfwgpzqnfabpwucygbl35wyq 115 10 relative relative JJ work_wtnfwgpzqnfabpwucygbl35wyq 115 11 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 115 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 115 13 rest rest NN work_wtnfwgpzqnfabpwucygbl35wyq 115 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 115 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 115 16 body body NN work_wtnfwgpzqnfabpwucygbl35wyq 115 17 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 115 18 cystic cystic JJ work_wtnfwgpzqnfabpwucygbl35wyq 115 19 replacement replacement NN work_wtnfwgpzqnfabpwucygbl35wyq 115 20 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 115 21 most most JJS work_wtnfwgpzqnfabpwucygbl35wyq 115 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 115 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 115 24 neural neural JJ work_wtnfwgpzqnfabpwucygbl35wyq 115 25 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 115 26 Figure Figure NNP work_wtnfwgpzqnfabpwucygbl35wyq 115 27 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 115 28 Morphological morphological JJ work_wtnfwgpzqnfabpwucygbl35wyq 115 29 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 115 30 histological histological JJ work_wtnfwgpzqnfabpwucygbl35wyq 115 31 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 115 32 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 115 33 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 115 34 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 115 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 116 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 116 2 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 116 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 116 4 Postmortem Postmortem NNP work_wtnfwgpzqnfabpwucygbl35wyq 116 5 photographs photograph NNS work_wtnfwgpzqnfabpwucygbl35wyq 116 6 depicting depict VBG work_wtnfwgpzqnfabpwucygbl35wyq 116 7 consistent consistent JJ work_wtnfwgpzqnfabpwucygbl35wyq 116 8 dysmorphology dysmorphology NN work_wtnfwgpzqnfabpwucygbl35wyq 116 9 among among IN work_wtnfwgpzqnfabpwucygbl35wyq 116 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 116 11 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 116 12 infants infant NNS work_wtnfwgpzqnfabpwucygbl35wyq 116 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 117 1 Features feature VBZ work_wtnfwgpzqnfabpwucygbl35wyq 117 2 secondary secondary JJ work_wtnfwgpzqnfabpwucygbl35wyq 117 3 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 117 4 Potter potter NN work_wtnfwgpzqnfabpwucygbl35wyq 117 5 deformation deformation NN work_wtnfwgpzqnfabpwucygbl35wyq 117 6 sequence sequence NN work_wtnfwgpzqnfabpwucygbl35wyq 117 7 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 117 8 evident evident JJ work_wtnfwgpzqnfabpwucygbl35wyq 117 9 : : : work_wtnfwgpzqnfabpwucygbl35wyq 117 10 microretrognathia microretrognathia NNP work_wtnfwgpzqnfabpwucygbl35wyq 117 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 117 12 flattened flatten VBD work_wtnfwgpzqnfabpwucygbl35wyq 117 13 face face NN work_wtnfwgpzqnfabpwucygbl35wyq 117 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 117 15 fifth fifth JJ work_wtnfwgpzqnfabpwucygbl35wyq 117 16 finger finger NN work_wtnfwgpzqnfabpwucygbl35wyq 117 17 clinodactyly clinodactyly NNP work_wtnfwgpzqnfabpwucygbl35wyq 117 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 117 19 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 117 20 palmar palmar NN work_wtnfwgpzqnfabpwucygbl35wyq 117 21 creases crease NNS work_wtnfwgpzqnfabpwucygbl35wyq 117 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 117 23 talipes talipe NNS work_wtnfwgpzqnfabpwucygbl35wyq 117 24 equinovarus equinovarus JJ work_wtnfwgpzqnfabpwucygbl35wyq 117 25 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 117 26 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 117 27 flexion flexion NN work_wtnfwgpzqnfabpwucygbl35wyq 117 28 contractures contracture NNS work_wtnfwgpzqnfabpwucygbl35wyq 117 29 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 117 30 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 117 31 depicted depict VBN work_wtnfwgpzqnfabpwucygbl35wyq 117 32 here here RB work_wtnfwgpzqnfabpwucygbl35wyq 117 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 117 34 . . . work_wtnfwgpzqnfabpwucygbl35wyq 118 1 Also also RB work_wtnfwgpzqnfabpwucygbl35wyq 118 2 evident evident JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 3 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 118 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 118 5 pinched pinched JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 6 nose nose NN work_wtnfwgpzqnfabpwucygbl35wyq 118 7 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 118 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 118 9 bulbous bulbous JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 10 tip tip NN work_wtnfwgpzqnfabpwucygbl35wyq 118 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 118 12 anteverted anteverte VBD work_wtnfwgpzqnfabpwucygbl35wyq 118 13 nares naris NNS work_wtnfwgpzqnfabpwucygbl35wyq 118 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 118 15 choanal choanal JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 16 narrowing narrowing NN work_wtnfwgpzqnfabpwucygbl35wyq 118 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 118 18 small small JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 19 palpebral palpebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 20 fissures fissure NNS work_wtnfwgpzqnfabpwucygbl35wyq 118 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 118 22 epicanthal epicanthal NNP work_wtnfwgpzqnfabpwucygbl35wyq 118 23 folds fold NNS work_wtnfwgpzqnfabpwucygbl35wyq 118 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 118 25 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 118 26 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 118 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 118 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 118 29 low low JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 30 set set NN work_wtnfwgpzqnfabpwucygbl35wyq 118 31 ears ear NNS work_wtnfwgpzqnfabpwucygbl35wyq 118 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 118 33 shortened shorten VBD work_wtnfwgpzqnfabpwucygbl35wyq 118 34 neck neck NN work_wtnfwgpzqnfabpwucygbl35wyq 118 35 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 118 36 redundant redundant JJ work_wtnfwgpzqnfabpwucygbl35wyq 118 37 skin skin NN work_wtnfwgpzqnfabpwucygbl35wyq 118 38 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 118 39 microstomia microstomia NN work_wtnfwgpzqnfabpwucygbl35wyq 118 40 . . . work_wtnfwgpzqnfabpwucygbl35wyq 119 1 Infant Infant NNP work_wtnfwgpzqnfabpwucygbl35wyq 119 2 306 306 CD work_wtnfwgpzqnfabpwucygbl35wyq 119 3 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 119 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 119 5 particularly particularly RB work_wtnfwgpzqnfabpwucygbl35wyq 119 6 small small JJ work_wtnfwgpzqnfabpwucygbl35wyq 119 7 mouth mouth NN work_wtnfwgpzqnfabpwucygbl35wyq 119 8 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 119 9 ankyloglossia ankyloglossia NNP work_wtnfwgpzqnfabpwucygbl35wyq 119 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 120 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 120 2 hands hand NNS work_wtnfwgpzqnfabpwucygbl35wyq 120 3 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 120 4 brachydactyly brachydactyly NNS work_wtnfwgpzqnfabpwucygbl35wyq 120 5 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 120 6 tapered tapered JJ work_wtnfwgpzqnfabpwucygbl35wyq 120 7 fingers finger NNS work_wtnfwgpzqnfabpwucygbl35wyq 120 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 120 9 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 120 10 shortened shorten VBN work_wtnfwgpzqnfabpwucygbl35wyq 120 11 fifth fifth JJ work_wtnfwgpzqnfabpwucygbl35wyq 120 12 finger finger NN work_wtnfwgpzqnfabpwucygbl35wyq 120 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 121 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 121 2 feet foot NNS work_wtnfwgpzqnfabpwucygbl35wyq 121 3 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 121 4 variable variable JJ work_wtnfwgpzqnfabpwucygbl35wyq 121 5 degrees degree NNS work_wtnfwgpzqnfabpwucygbl35wyq 121 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 121 7 cutaneous cutaneous NN work_wtnfwgpzqnfabpwucygbl35wyq 121 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 121 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 121 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 121 11 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 121 12 case case NN work_wtnfwgpzqnfabpwucygbl35wyq 121 13 osseous osseous JJ work_wtnfwgpzqnfabpwucygbl35wyq 121 14 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 121 15 syndactyly syndactyly RB work_wtnfwgpzqnfabpwucygbl35wyq 121 16 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 121 17 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 121 18 wide wide JJ work_wtnfwgpzqnfabpwucygbl35wyq 121 19 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 121 20 webspace webspace NN work_wtnfwgpzqnfabpwucygbl35wyq 121 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 122 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 122 2 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 122 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 122 4 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 122 5 utero utero JJ work_wtnfwgpzqnfabpwucygbl35wyq 122 6 sonograms sonograms NN work_wtnfwgpzqnfabpwucygbl35wyq 122 7 showing show VBG work_wtnfwgpzqnfabpwucygbl35wyq 122 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 122 9 progression progression NN work_wtnfwgpzqnfabpwucygbl35wyq 122 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 122 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 122 12 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 122 13 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 122 14 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 122 15 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 122 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 123 1 Gestational gestational JJ work_wtnfwgpzqnfabpwucygbl35wyq 123 2 age age NN work_wtnfwgpzqnfabpwucygbl35wyq 123 3 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 123 4 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 123 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 123 6 upper upper JJ work_wtnfwgpzqnfabpwucygbl35wyq 123 7 corner corner NN work_wtnfwgpzqnfabpwucygbl35wyq 123 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 123 9 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 123 10 photograph photograph NN work_wtnfwgpzqnfabpwucygbl35wyq 123 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 124 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 124 2 cystic cystic JJ work_wtnfwgpzqnfabpwucygbl35wyq 124 3 hygroma hygroma NN work_wtnfwgpzqnfabpwucygbl35wyq 124 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 124 5 highlighted highlight VBN work_wtnfwgpzqnfabpwucygbl35wyq 124 6 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 124 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 124 8 white white NNP work_wtnfwgpzqnfabpwucygbl35wyq 124 9 arrowhead arrowhead NNP work_wtnfwgpzqnfabpwucygbl35wyq 124 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 125 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 125 2 C c NN work_wtnfwgpzqnfabpwucygbl35wyq 125 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 125 4 Postmortem Postmortem NNP work_wtnfwgpzqnfabpwucygbl35wyq 125 5 MRI MRI NNP work_wtnfwgpzqnfabpwucygbl35wyq 125 6 scan scan NN work_wtnfwgpzqnfabpwucygbl35wyq 125 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 125 8 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 125 9 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 125 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 126 1 Shown Shown NNP work_wtnfwgpzqnfabpwucygbl35wyq 126 2 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 126 3 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 126 4 slightly slightly RB work_wtnfwgpzqnfabpwucygbl35wyq 126 5 off off JJ work_wtnfwgpzqnfabpwucygbl35wyq 126 6 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 126 7 sagittal sagittal JJ work_wtnfwgpzqnfabpwucygbl35wyq 126 8 view view NN work_wtnfwgpzqnfabpwucygbl35wyq 126 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 126 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 126 11 cranium cranium NN work_wtnfwgpzqnfabpwucygbl35wyq 126 12 depicting depict VBG work_wtnfwgpzqnfabpwucygbl35wyq 126 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 126 14 almost almost RB work_wtnfwgpzqnfabpwucygbl35wyq 126 15 complete complete JJ work_wtnfwgpzqnfabpwucygbl35wyq 126 16 absence absence NN work_wtnfwgpzqnfabpwucygbl35wyq 126 17 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 126 18 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 126 19 cerebral cerebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 126 20 hemispheres hemisphere NNS work_wtnfwgpzqnfabpwucygbl35wyq 126 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 127 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 127 2 hypoplastic hypoplastic JJ work_wtnfwgpzqnfabpwucygbl35wyq 127 3 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 127 4 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 127 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 127 6 frontotemporal frontotemporal JJ work_wtnfwgpzqnfabpwucygbl35wyq 127 7 region region NN work_wtnfwgpzqnfabpwucygbl35wyq 127 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 127 9 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 127 10 within within IN work_wtnfwgpzqnfabpwucygbl35wyq 127 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 127 12 posterior posterior NNP work_wtnfwgpzqnfabpwucygbl35wyq 127 13 fossa fossa NNP work_wtnfwgpzqnfabpwucygbl35wyq 127 14 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 127 15 evident evident JJ work_wtnfwgpzqnfabpwucygbl35wyq 127 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 128 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 128 2 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 128 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 128 4 Postmortem Postmortem NNP work_wtnfwgpzqnfabpwucygbl35wyq 128 5 view view NN work_wtnfwgpzqnfabpwucygbl35wyq 128 6 inside inside IN work_wtnfwgpzqnfabpwucygbl35wyq 128 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 128 8 cranial cranial JJ work_wtnfwgpzqnfabpwucygbl35wyq 128 9 vault vault NN work_wtnfwgpzqnfabpwucygbl35wyq 128 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 128 11 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 128 12 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 128 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 129 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 129 2 view view NN work_wtnfwgpzqnfabpwucygbl35wyq 129 3 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 129 4 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 129 5 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 129 6 occipital occipital JJ work_wtnfwgpzqnfabpwucygbl35wyq 129 7 opening opening NN work_wtnfwgpzqnfabpwucygbl35wyq 129 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 129 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 129 10 lack lack NN work_wtnfwgpzqnfabpwucygbl35wyq 129 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 129 12 most most JJS work_wtnfwgpzqnfabpwucygbl35wyq 129 13 neural neural JJ work_wtnfwgpzqnfabpwucygbl35wyq 129 14 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 129 15 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 129 16 evident evident JJ work_wtnfwgpzqnfabpwucygbl35wyq 129 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 130 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 130 2 top top NN work_wtnfwgpzqnfabpwucygbl35wyq 130 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 130 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 130 5 cerebellum cerebellum NN work_wtnfwgpzqnfabpwucygbl35wyq 130 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 130 7 brainstem brainstem NN work_wtnfwgpzqnfabpwucygbl35wyq 130 8 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 130 9 visible visible JJ work_wtnfwgpzqnfabpwucygbl35wyq 130 10 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 130 11 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 130 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 130 13 remnants remnant NNS work_wtnfwgpzqnfabpwucygbl35wyq 130 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 130 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 130 16 frontotemporal frontotemporal JJ work_wtnfwgpzqnfabpwucygbl35wyq 130 17 lobes lobe NNS work_wtnfwgpzqnfabpwucygbl35wyq 130 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 131 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 131 2 E e NN work_wtnfwgpzqnfabpwucygbl35wyq 131 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 131 4 NeuN NeuN NNP work_wtnfwgpzqnfabpwucygbl35wyq 131 5 immunolabelling immunolabelling NN work_wtnfwgpzqnfabpwucygbl35wyq 131 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 131 7 frontal frontal JJ work_wtnfwgpzqnfabpwucygbl35wyq 131 8 lobe lobe NN work_wtnfwgpzqnfabpwucygbl35wyq 131 9 sections section NNS work_wtnfwgpzqnfabpwucygbl35wyq 131 10 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 131 11 100× 100× CD work_wtnfwgpzqnfabpwucygbl35wyq 131 12 magnification magnification NN work_wtnfwgpzqnfabpwucygbl35wyq 131 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 132 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 132 2 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 132 3 neuron neuron NN work_wtnfwgpzqnfabpwucygbl35wyq 132 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 132 5 highlighted highlight VBN work_wtnfwgpzqnfabpwucygbl35wyq 132 6 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 132 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 132 8 strong strong JJ work_wtnfwgpzqnfabpwucygbl35wyq 132 9 NeuN NeuN NNP work_wtnfwgpzqnfabpwucygbl35wyq 132 10 staining staining NN work_wtnfwgpzqnfabpwucygbl35wyq 132 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 133 1 Such such JJ work_wtnfwgpzqnfabpwucygbl35wyq 133 2 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 133 3 represent represent VBP work_wtnfwgpzqnfabpwucygbl35wyq 133 4 5–10 5–10 NNP work_wtnfwgpzqnfabpwucygbl35wyq 133 5 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 133 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 133 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 133 8 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 133 9 amongst amongst IN work_wtnfwgpzqnfabpwucygbl35wyq 133 10 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 133 11 sections section NNS work_wtnfwgpzqnfabpwucygbl35wyq 133 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 134 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 134 2 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 134 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 134 4 Glial Glial NNP work_wtnfwgpzqnfabpwucygbl35wyq 134 5 fibrillary fibrillary JJ work_wtnfwgpzqnfabpwucygbl35wyq 134 6 acidic acidic JJ work_wtnfwgpzqnfabpwucygbl35wyq 134 7 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 134 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 134 9 GFAP GFAP NNP work_wtnfwgpzqnfabpwucygbl35wyq 134 10 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 134 11 immunolabelling immunolabelling NN work_wtnfwgpzqnfabpwucygbl35wyq 134 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 134 13 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 134 14 frontal frontal JJ work_wtnfwgpzqnfabpwucygbl35wyq 134 15 lobe lobe NN work_wtnfwgpzqnfabpwucygbl35wyq 134 16 section section NN work_wtnfwgpzqnfabpwucygbl35wyq 134 17 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 134 18 60× 60× CD work_wtnfwgpzqnfabpwucygbl35wyq 134 19 magnification magnification NN work_wtnfwgpzqnfabpwucygbl35wyq 134 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 135 1 Multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 135 2 nuclei nucleus NNS work_wtnfwgpzqnfabpwucygbl35wyq 135 3 within within IN work_wtnfwgpzqnfabpwucygbl35wyq 135 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 135 5 glial glial JJ work_wtnfwgpzqnfabpwucygbl35wyq 135 6 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 135 7 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 135 8 astrocyte astrocyte NNP work_wtnfwgpzqnfabpwucygbl35wyq 135 9 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 135 10 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 135 11 highlighted highlight VBN work_wtnfwgpzqnfabpwucygbl35wyq 135 12 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 135 13 black black JJ work_wtnfwgpzqnfabpwucygbl35wyq 135 14 arrowheads arrowhead NNS work_wtnfwgpzqnfabpwucygbl35wyq 135 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 136 1 Multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 136 2 glial glial JJ work_wtnfwgpzqnfabpwucygbl35wyq 136 3 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 136 4 tended tend VBD work_wtnfwgpzqnfabpwucygbl35wyq 136 5 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 136 6 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 136 7 less less RBR work_wtnfwgpzqnfabpwucygbl35wyq 136 8 common common JJ work_wtnfwgpzqnfabpwucygbl35wyq 136 9 than than IN work_wtnfwgpzqnfabpwucygbl35wyq 136 10 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 136 11 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 136 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 136 13 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 136 14 sections section NNS work_wtnfwgpzqnfabpwucygbl35wyq 136 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 137 1 493Frosk 493Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 137 2   _SP work_wtnfwgpzqnfabpwucygbl35wyq 137 3 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 137 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 137 5 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 137 6   _SP work_wtnfwgpzqnfabpwucygbl35wyq 137 7 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 137 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 138 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 138 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 138 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 138 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 138 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 139 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 139 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 139 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 139 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 139 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 139 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 139 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 139 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 139 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 139 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 139 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 139 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 139 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 139 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 139 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 139 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 139 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 139 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 139 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 139 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 139 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 139 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 139 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 139 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 139 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 139 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 139 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 139 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 139 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 140 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 140 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 140 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 140 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 12 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 13 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 140 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 140 15 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 140 16 1B 1b NN work_wtnfwgpzqnfabpwucygbl35wyq 140 17 – – : work_wtnfwgpzqnfabpwucygbl35wyq 140 18 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 140 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 140 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 141 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 141 2 cerebellum cerebellum NN work_wtnfwgpzqnfabpwucygbl35wyq 141 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 141 4 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 141 5 stem stem NN work_wtnfwgpzqnfabpwucygbl35wyq 141 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 141 7 basal basal NN work_wtnfwgpzqnfabpwucygbl35wyq 141 8 nuclei nucleus NNS work_wtnfwgpzqnfabpwucygbl35wyq 141 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 141 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 141 11 basal basal NN work_wtnfwgpzqnfabpwucygbl35wyq 141 12 portions portion NNS work_wtnfwgpzqnfabpwucygbl35wyq 141 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 141 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 141 15 temporal temporal JJ work_wtnfwgpzqnfabpwucygbl35wyq 141 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 141 17 frontal frontal JJ work_wtnfwgpzqnfabpwucygbl35wyq 141 18 lobes lobe NNS work_wtnfwgpzqnfabpwucygbl35wyq 141 19 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 141 20 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 141 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 141 22 although although IN work_wtnfwgpzqnfabpwucygbl35wyq 141 23 hypoplastic hypoplastic JJ work_wtnfwgpzqnfabpwucygbl35wyq 141 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 142 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 142 2 bulk bulk NN work_wtnfwgpzqnfabpwucygbl35wyq 142 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 142 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 142 5 cerebral cerebral NNP work_wtnfwgpzqnfabpwucygbl35wyq 142 6 cortex cortex NNP work_wtnfwgpzqnfabpwucygbl35wyq 142 7 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 142 8 absent absent JJ work_wtnfwgpzqnfabpwucygbl35wyq 142 9 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 142 10 reduced reduce VBN work_wtnfwgpzqnfabpwucygbl35wyq 142 11 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 142 12 islands island NNS work_wtnfwgpzqnfabpwucygbl35wyq 142 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 142 14 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 142 15 attached attach VBN work_wtnfwgpzqnfabpwucygbl35wyq 142 16 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 142 17 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 142 18 leptomenin- leptomenin- JJ work_wtnfwgpzqnfabpwucygbl35wyq 142 19 geal geal JJ work_wtnfwgpzqnfabpwucygbl35wyq 142 20 sac sac NN work_wtnfwgpzqnfabpwucygbl35wyq 142 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 142 22 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 142 23 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 142 24 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 142 25 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 142 26 S2.5A S2.5A NNP work_wtnfwgpzqnfabpwucygbl35wyq 142 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 142 28 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 142 29 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 142 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 143 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 143 2 assess assess VB work_wtnfwgpzqnfabpwucygbl35wyq 143 3 pathology pathology NN work_wtnfwgpzqnfabpwucygbl35wyq 143 4 further far RBR work_wtnfwgpzqnfabpwucygbl35wyq 143 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 143 6 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 143 7 conducted conduct VBD work_wtnfwgpzqnfabpwucygbl35wyq 143 8 microscopic microscopic JJ work_wtnfwgpzqnfabpwucygbl35wyq 143 9 examination examination NN work_wtnfwgpzqnfabpwucygbl35wyq 143 10 ; ; , work_wtnfwgpzqnfabpwucygbl35wyq 143 11 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 143 12 analyses analysis NNS work_wtnfwgpzqnfabpwucygbl35wyq 143 13 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 143 14 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 143 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 143 16 temporal temporal JJ work_wtnfwgpzqnfabpwucygbl35wyq 143 17 cortex cortex NN work_wtnfwgpzqnfabpwucygbl35wyq 143 18 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 143 19 disorga- disorga- NN work_wtnfwgpzqnfabpwucygbl35wyq 143 20 nised nise VBN work_wtnfwgpzqnfabpwucygbl35wyq 143 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 144 1 Approximately approximately RB work_wtnfwgpzqnfabpwucygbl35wyq 144 2 5–10 5–10 NNP work_wtnfwgpzqnfabpwucygbl35wyq 144 3 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 144 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 144 5 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 144 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 144 7 glial glial JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 8 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 144 9 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 144 10 multinucleated multinucleate VBN work_wtnfwgpzqnfabpwucygbl35wyq 144 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 144 12 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 144 13 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 144 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 144 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 144 16 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 144 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 144 18 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 144 19 1E 1E NNP work_wtnfwgpzqnfabpwucygbl35wyq 144 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 144 21 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 144 22 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 144 23 as as RB work_wtnfwgpzqnfabpwucygbl35wyq 144 24 well well RB work_wtnfwgpzqnfabpwucygbl35wyq 144 25 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 144 26 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 144 27 retroperitoneal retroperitoneal JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 28 sympathetic sympathetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 29 ganglia ganglia NN work_wtnfwgpzqnfabpwucygbl35wyq 144 30 adjacent adjacent JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 31 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 144 32 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 144 33 kidney kidney NN work_wtnfwgpzqnfabpwucygbl35wyq 144 34 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 144 35 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 144 36 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 144 37 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 38 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 39 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 144 40 S2.10B S2.10B NNP work_wtnfwgpzqnfabpwucygbl35wyq 144 41 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 144 42 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 144 43 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 144 44 ganglion ganglion NN work_wtnfwgpzqnfabpwucygbl35wyq 144 45 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 144 46 layer layer NN work_wtnfwgpzqnfabpwucygbl35wyq 144 47 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 144 48 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 144 49 retina retina NNP work_wtnfwgpzqnfabpwucygbl35wyq 144 50 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 144 51 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 144 52 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 53 supplemental supplemental JJ work_wtnfwgpzqnfabpwucygbl35wyq 144 54 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 144 55 S2.10E s2.10e NN work_wtnfwgpzqnfabpwucygbl35wyq 144 56 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 144 57 . . . work_wtnfwgpzqnfabpwucygbl35wyq 145 1 Normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 2 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 3 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 145 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 145 5 even even RB work_wtnfwgpzqnfabpwucygbl35wyq 145 6 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 145 7 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 145 8 early early JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 9 developmental developmental JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 10 stage stage NN work_wtnfwgpzqnfabpwucygbl35wyq 145 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 145 12 does do VBZ work_wtnfwgpzqnfabpwucygbl35wyq 145 13 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 145 14 have have VB work_wtnfwgpzqnfabpwucygbl35wyq 145 15 such such JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 16 abnormal abnormal JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 17 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 145 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 145 19 although although IN work_wtnfwgpzqnfabpwucygbl35wyq 145 20 they -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 145 21 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 145 22 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 145 23 reported report VBN work_wtnfwgpzqnfabpwucygbl35wyq 145 24 recently recently RB work_wtnfwgpzqnfabpwucygbl35wyq 145 25 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 145 26 association association NN work_wtnfwgpzqnfabpwucygbl35wyq 145 27 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 145 28 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 145 29 severe severe JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 30 form form NN work_wtnfwgpzqnfabpwucygbl35wyq 145 31 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 145 32 primary primary JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 33 microcephaly microcephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 145 34 caused cause VBN work_wtnfwgpzqnfabpwucygbl35wyq 145 35 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 145 36 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 37 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 38 mutations mutation NNS work_wtnfwgpzqnfabpwucygbl35wyq 145 39 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 145 40 CIT CIT NNP work_wtnfwgpzqnfabpwucygbl35wyq 145 41 , , , work_wtnfwgpzqnfabpwucygbl35wyq 145 42 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 145 43 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 145 44 involved involve VBN work_wtnfwgpzqnfabpwucygbl35wyq 145 45 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 145 46 cytokinesis.23 cytokinesis.23 NNP work_wtnfwgpzqnfabpwucygbl35wyq 145 47 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 145 48 did do VBD work_wtnfwgpzqnfabpwucygbl35wyq 145 49 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 145 50 appreciate appreciate VB work_wtnfwgpzqnfabpwucygbl35wyq 145 51 any any DT work_wtnfwgpzqnfabpwucygbl35wyq 145 52 evi- evi- NNS work_wtnfwgpzqnfabpwucygbl35wyq 145 53 dence dence NN work_wtnfwgpzqnfabpwucygbl35wyq 145 54 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 145 55 infection infection NN work_wtnfwgpzqnfabpwucygbl35wyq 145 56 , , , work_wtnfwgpzqnfabpwucygbl35wyq 145 57 inflammation inflammation NN work_wtnfwgpzqnfabpwucygbl35wyq 145 58 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 145 59 vascular vascular JJ work_wtnfwgpzqnfabpwucygbl35wyq 145 60 obstruction obstruction NN work_wtnfwgpzqnfabpwucygbl35wyq 145 61 . . . work_wtnfwgpzqnfabpwucygbl35wyq 146 1 Several several JJ work_wtnfwgpzqnfabpwucygbl35wyq 146 2 known know VBN work_wtnfwgpzqnfabpwucygbl35wyq 146 3 syndromes syndrome VBZ work_wtnfwgpzqnfabpwucygbl35wyq 146 4 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 146 5 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 146 6 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 146 7 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 146 8 rare rare JJ work_wtnfwgpzqnfabpwucygbl35wyq 146 9 feature feature NN work_wtnfwgpzqnfabpwucygbl35wyq 146 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 146 11 including include VBG work_wtnfwgpzqnfabpwucygbl35wyq 146 12 Cousin Cousin NNP work_wtnfwgpzqnfabpwucygbl35wyq 146 13 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 146 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 146 15 OMIM#260660 OMIM#260660 NNP work_wtnfwgpzqnfabpwucygbl35wyq 146 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 146 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 146 18 Neu Neu NNP work_wtnfwgpzqnfabpwucygbl35wyq 146 19 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 146 20 Laxova Laxova NNP work_wtnfwgpzqnfabpwucygbl35wyq 146 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 146 22 OMIM#256520 OMIM#256520 NNS work_wtnfwgpzqnfabpwucygbl35wyq 146 23 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 146 24 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 146 25 Roberts Roberts NNP work_wtnfwgpzqnfabpwucygbl35wyq 146 26 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 146 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 146 28 OMIM OMIM NNP work_wtnfwgpzqnfabpwucygbl35wyq 146 29 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 146 30 268300 268300 CD work_wtnfwgpzqnfabpwucygbl35wyq 146 31 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 146 32 . . . work_wtnfwgpzqnfabpwucygbl35wyq 147 1 However however RB work_wtnfwgpzqnfabpwucygbl35wyq 147 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 147 3 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 147 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 147 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 147 6 primary primary JJ work_wtnfwgpzqnfabpwucygbl35wyq 147 7 feature feature NN work_wtnfwgpzqnfabpwucygbl35wyq 147 8 only only RB work_wtnfwgpzqnfabpwucygbl35wyq 147 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 147 10 proliferative proliferative JJ work_wtnfwgpzqnfabpwucygbl35wyq 147 11 vasculopathy vasculopathy NN work_wtnfwgpzqnfabpwucygbl35wyq 147 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 147 13 hydranencephaly- hydranencephaly- NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 14 hydrocephaly hydrocephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 15 syndrome syndrome NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 147 17 OMIM#225790 OMIM#225790 NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 147 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 147 20 microhydranence- microhydranence- NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 21 phaly phaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 147 23 OMIM#605013 OMIM#605013 NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 24 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 147 25 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 147 26 hydranencephaly hydranencephaly VB work_wtnfwgpzqnfabpwucygbl35wyq 147 27 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 147 28 abnormal abnormal JJ work_wtnfwgpzqnfabpwucygbl35wyq 147 29 genitalia genitalia NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 30 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 147 31 OMIM#300215 OMIM#300215 NNP work_wtnfwgpzqnfabpwucygbl35wyq 147 32 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 147 33 . . . work_wtnfwgpzqnfabpwucygbl35wyq 148 1 None none NN work_wtnfwgpzqnfabpwucygbl35wyq 148 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 148 3 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 148 4 coincide coincide NN work_wtnfwgpzqnfabpwucygbl35wyq 148 5 clinically clinically RB work_wtnfwgpzqnfabpwucygbl35wyq 148 6 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 148 7 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 148 8 patients patient NNS work_wtnfwgpzqnfabpwucygbl35wyq 148 9 ’ ’ POS work_wtnfwgpzqnfabpwucygbl35wyq 148 10 presentation presentation NN work_wtnfwgpzqnfabpwucygbl35wyq 148 11 due due IN work_wtnfwgpzqnfabpwucygbl35wyq 148 12 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 148 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 148 14 lack lack NN work_wtnfwgpzqnfabpwucygbl35wyq 148 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 148 16 vascular vascular JJ work_wtnfwgpzqnfabpwucygbl35wyq 148 17 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 148 18 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 148 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 148 20 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 148 21 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 148 22 proportionate proportionate NN work_wtnfwgpzqnfabpwucygbl35wyq 148 23 head head NN work_wtnfwgpzqnfabpwucygbl35wyq 148 24 size size NN work_wtnfwgpzqnfabpwucygbl35wyq 148 25 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 148 26 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 148 27 genitalia genitalia NNP work_wtnfwgpzqnfabpwucygbl35wyq 148 28 ; ; , work_wtnfwgpzqnfabpwucygbl35wyq 148 29 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 148 30 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 148 31 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 148 32 characteristic characteristic JJ work_wtnfwgpzqnfabpwucygbl35wyq 148 33 dysmorphic dysmorphic JJ work_wtnfwgpzqnfabpwucygbl35wyq 148 34 features feature NNS work_wtnfwgpzqnfabpwucygbl35wyq 148 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 149 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 149 2 closest close JJS work_wtnfwgpzqnfabpwucygbl35wyq 149 3 match match NN work_wtnfwgpzqnfabpwucygbl35wyq 149 4 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 149 5 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 149 6 patients patient NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 7 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 149 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 149 9 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 10 case case NN work_wtnfwgpzqnfabpwucygbl35wyq 149 11 report report NN work_wtnfwgpzqnfabpwucygbl35wyq 149 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 149 13 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 149 14 male male JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 15 siblings sibling NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 16 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 149 17 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 149 18 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 149 19 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 20 aplasia aplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 149 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 149 22 OMIM#236500).24 OMIM#236500).24 NNP work_wtnfwgpzqnfabpwucygbl35wyq 149 23 Through through IN work_wtnfwgpzqnfabpwucygbl35wyq 149 24 further further JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 25 literature literature NN work_wtnfwgpzqnfabpwucygbl35wyq 149 26 searches search NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 149 28 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 149 29 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 149 30 four four CD work_wtnfwgpzqnfabpwucygbl35wyq 149 31 more more JJR work_wtnfwgpzqnfabpwucygbl35wyq 149 32 reports report NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 33 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 149 34 infants infant NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 35 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 149 36 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 149 37 combination combination NN work_wtnfwgpzqnfabpwucygbl35wyq 149 38 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 149 39 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 149 40 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 149 41 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 42 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 43 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 149 44 aplasia.24–28 aplasia.24–28 NNP work_wtnfwgpzqnfabpwucygbl35wyq 149 45 These these DT work_wtnfwgpzqnfabpwucygbl35wyq 149 46 nine nine CD work_wtnfwgpzqnfabpwucygbl35wyq 149 47 reported report VBD work_wtnfwgpzqnfabpwucygbl35wyq 149 48 infants infant NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 49 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 149 50 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 149 51 remarkably remarkably RB work_wtnfwgpzqnfabpwucygbl35wyq 149 52 similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 53 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 54 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 149 55 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 149 56 patients patient NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 57 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 149 58 table table NN work_wtnfwgpzqnfabpwucygbl35wyq 149 59 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 149 60 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 149 61 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 149 62 they -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 149 63 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 149 64 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 149 65 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 149 66 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 149 67 eight eight CD work_wtnfwgpzqnfabpwucygbl35wyq 149 68 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 149 69 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 149 70 nine nine CD work_wtnfwgpzqnfabpwucygbl35wyq 149 71 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 149 72 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 73 aplasia aplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 149 74 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 149 75 severe severe JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 76 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 149 77 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 149 78 . . . work_wtnfwgpzqnfabpwucygbl35wyq 150 1 One one CD work_wtnfwgpzqnfabpwucygbl35wyq 150 2 child child NN work_wtnfwgpzqnfabpwucygbl35wyq 150 3 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 150 4 presumably presumably RB work_wtnfwgpzqnfabpwucygbl35wyq 150 5 functioning function VBG work_wtnfwgpzqnfabpwucygbl35wyq 150 6 kidneys kidney NNS work_wtnfwgpzqnfabpwucygbl35wyq 150 7 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 150 8 given give VBN work_wtnfwgpzqnfabpwucygbl35wyq 150 9 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 150 10 he -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 150 11 survived survive VBD work_wtnfwgpzqnfabpwucygbl35wyq 150 12 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 150 13 more more JJR work_wtnfwgpzqnfabpwucygbl35wyq 150 14 than than IN work_wtnfwgpzqnfabpwucygbl35wyq 150 15 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 150 16 month month NN work_wtnfwgpzqnfabpwucygbl35wyq 150 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 150 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 150 19 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 150 20 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 150 21 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 150 22 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 150 23 clear clear JJ work_wtnfwgpzqnfabpwucygbl35wyq 150 24 whether whether IN work_wtnfwgpzqnfabpwucygbl35wyq 150 25 there there EX work_wtnfwgpzqnfabpwucygbl35wyq 150 26 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 150 27 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 150 28 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 150 29 since since IN work_wtnfwgpzqnfabpwucygbl35wyq 150 30 he -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 150 31 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 150 32 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 150 33 investigated investigate VBN work_wtnfwgpzqnfabpwucygbl35wyq 150 34 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 150 35 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 150 36 respect.26 respect.26 NNP work_wtnfwgpzqnfabpwucygbl35wyq 150 37 He -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 150 38 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 150 39 has have VBZ work_wtnfwgpzqnfabpwucygbl35wyq 150 40 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 150 41 same same JJ work_wtnfwgpzqnfabpwucygbl35wyq 150 42 disorder disorder NN work_wtnfwgpzqnfabpwucygbl35wyq 150 43 , , , work_wtnfwgpzqnfabpwucygbl35wyq 150 44 given give VBN work_wtnfwgpzqnfabpwucygbl35wyq 150 45 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 150 46 his -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 150 47 sister sister NN work_wtnfwgpzqnfabpwucygbl35wyq 150 48 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 150 49 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 150 50 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 150 51 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 150 52 . . . work_wtnfwgpzqnfabpwucygbl35wyq 151 1 Of of IN work_wtnfwgpzqnfabpwucygbl35wyq 151 2 those those DT work_wtnfwgpzqnfabpwucygbl35wyq 151 3 patients patient NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 4 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 151 5 neuropathological neuropathological JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 6 examin- examin- NN work_wtnfwgpzqnfabpwucygbl35wyq 151 7 ation ation NN work_wtnfwgpzqnfabpwucygbl35wyq 151 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 151 9 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 151 10 high high JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 11 incidence incidence NN work_wtnfwgpzqnfabpwucygbl35wyq 151 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 151 13 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 14 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 15 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 151 16 described.24 described.24 NNP work_wtnfwgpzqnfabpwucygbl35wyq 151 17 25 25 CD work_wtnfwgpzqnfabpwucygbl35wyq 151 18 At at IN work_wtnfwgpzqnfabpwucygbl35wyq 151 19 least least JJS work_wtnfwgpzqnfabpwucygbl35wyq 151 20 five five CD work_wtnfwgpzqnfabpwucygbl35wyq 151 21 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 151 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 151 23 infants infant NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 24 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 151 25 unusual unusual JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 26 feet foot NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 151 28 including include VBG work_wtnfwgpzqnfabpwucygbl35wyq 151 29 large large JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 30 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 31 web web NN work_wtnfwgpzqnfabpwucygbl35wyq 151 32 spaces space NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 33 and/or and/or CC work_wtnfwgpzqnfabpwucygbl35wyq 151 34 syndactyly.24 syndactyly.24 NNP work_wtnfwgpzqnfabpwucygbl35wyq 151 35 26 26 CD work_wtnfwgpzqnfabpwucygbl35wyq 151 36 Of of IN work_wtnfwgpzqnfabpwucygbl35wyq 151 37 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 151 38 nine nine CD work_wtnfwgpzqnfabpwucygbl35wyq 151 39 cases case NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 151 41 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 151 42 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 151 43 singletons singleton NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 44 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 151 45 seven seven CD work_wtnfwgpzqnfabpwucygbl35wyq 151 46 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 151 47 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 151 48 families family NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 49 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 151 50 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 151 51 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 151 52 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 151 53 affected affected JJ work_wtnfwgpzqnfabpwucygbl35wyq 151 54 children child NNS work_wtnfwgpzqnfabpwucygbl35wyq 151 55 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 151 56 . . . work_wtnfwgpzqnfabpwucygbl35wyq 152 1 Four four CD work_wtnfwgpzqnfabpwucygbl35wyq 152 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 152 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 152 4 nine nine CD work_wtnfwgpzqnfabpwucygbl35wyq 152 5 reported report VBN work_wtnfwgpzqnfabpwucygbl35wyq 152 6 cases case NNS work_wtnfwgpzqnfabpwucygbl35wyq 152 7 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 152 8 female female JJ work_wtnfwgpzqnfabpwucygbl35wyq 152 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 153 1 Combined combine VBN work_wtnfwgpzqnfabpwucygbl35wyq 153 2 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 153 3 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 153 4 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 153 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 153 6 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 153 7 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 153 8 argue argue VBP work_wtnfwgpzqnfabpwucygbl35wyq 153 9 strongly strongly RB work_wtnfwgpzqnfabpwucygbl35wyq 153 10 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 153 11 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 153 12 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 13 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 153 14 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 15 aetiology aetiology NN work_wtnfwgpzqnfabpwucygbl35wyq 153 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 153 17 particu- particu- VBD work_wtnfwgpzqnfabpwucygbl35wyq 153 18 larly larly RB work_wtnfwgpzqnfabpwucygbl35wyq 153 19 since since IN work_wtnfwgpzqnfabpwucygbl35wyq 153 20 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 153 21 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 153 22 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 153 23 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 153 24 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 153 25 population population NN work_wtnfwgpzqnfabpwucygbl35wyq 153 26 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 153 27 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 153 28 strong strong JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 29 founder founder NN work_wtnfwgpzqnfabpwucygbl35wyq 153 30 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 153 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 153 32 although although IN work_wtnfwgpzqnfabpwucygbl35wyq 153 33 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 153 34 can can MD work_wtnfwgpzqnfabpwucygbl35wyq 153 35 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 153 36 definitively definitively RB work_wtnfwgpzqnfabpwucygbl35wyq 153 37 rule rule VB work_wtnfwgpzqnfabpwucygbl35wyq 153 38 out out RP work_wtnfwgpzqnfabpwucygbl35wyq 153 39 alterna- alterna- JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 40 tive tive JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 41 aetiologies aetiology NNS work_wtnfwgpzqnfabpwucygbl35wyq 153 42 such such JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 43 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 153 44 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 153 45 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 153 46 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 153 47 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 153 48 inheritance inheritance NN work_wtnfwgpzqnfabpwucygbl35wyq 153 49 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 153 50 multiple multiple NN work_wtnfwgpzqnfabpwucygbl35wyq 153 51 inde- inde- JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 52 pendent pendent NN work_wtnfwgpzqnfabpwucygbl35wyq 153 53 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 153 54 effects.29 effects.29 NNP work_wtnfwgpzqnfabpwucygbl35wyq 153 55 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 153 56 propose propose VBP work_wtnfwgpzqnfabpwucygbl35wyq 153 57 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 153 58 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 153 59 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 153 60 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 153 61 known know VBN work_wtnfwgpzqnfabpwucygbl35wyq 153 62 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 153 63 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 153 64 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 153 65 . . . work_wtnfwgpzqnfabpwucygbl35wyq 154 1 Gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 154 2 identification identification NN work_wtnfwgpzqnfabpwucygbl35wyq 154 3 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 154 4 obtained obtain VBD work_wtnfwgpzqnfabpwucygbl35wyq 154 5 postmortem postmortem NN work_wtnfwgpzqnfabpwucygbl35wyq 154 6 DNA dna NN work_wtnfwgpzqnfabpwucygbl35wyq 154 7 samples sample NNS work_wtnfwgpzqnfabpwucygbl35wyq 154 8 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 154 9 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 154 10 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 154 11 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 154 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 155 1 An an DT work_wtnfwgpzqnfabpwucygbl35wyq 155 2 amnion amnion NN work_wtnfwgpzqnfabpwucygbl35wyq 155 3 sample sample NN work_wtnfwgpzqnfabpwucygbl35wyq 155 4 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 155 5 Infant Infant NNP work_wtnfwgpzqnfabpwucygbl35wyq 155 6 303 303 CD work_wtnfwgpzqnfabpwucygbl35wyq 155 7 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 155 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 155 9 46,XY 46,xy CD work_wtnfwgpzqnfabpwucygbl35wyq 155 10 karyotype karyotype NN work_wtnfwgpzqnfabpwucygbl35wyq 155 11 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 155 12 400 400 CD work_wtnfwgpzqnfabpwucygbl35wyq 155 13 band band NN work_wtnfwgpzqnfabpwucygbl35wyq 155 14 resolution resolution NN work_wtnfwgpzqnfabpwucygbl35wyq 155 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 156 1 DNA dna NN work_wtnfwgpzqnfabpwucygbl35wyq 156 2 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 156 3 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 156 4 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 156 5 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 156 6 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 156 7 extracted extract VBN work_wtnfwgpzqnfabpwucygbl35wyq 156 8 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 156 9 cultured cultured JJ work_wtnfwgpzqnfabpwucygbl35wyq 156 10 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 156 11 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 156 12 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 156 13 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 156 14 chromosomal chromosomal NN work_wtnfwgpzqnfabpwucygbl35wyq 156 15 micro- micro- JJ work_wtnfwgpzqnfabpwucygbl35wyq 156 16 array array NN work_wtnfwgpzqnfabpwucygbl35wyq 156 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 156 18 ruling rule VBG work_wtnfwgpzqnfabpwucygbl35wyq 156 19 out out RP work_wtnfwgpzqnfabpwucygbl35wyq 156 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 156 21 possibility possibility NN work_wtnfwgpzqnfabpwucygbl35wyq 156 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 156 23 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 156 24 copy copy NN work_wtnfwgpzqnfabpwucygbl35wyq 156 25 number number NN work_wtnfwgpzqnfabpwucygbl35wyq 156 26 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 156 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 156 28 180 180 CD work_wtnfwgpzqnfabpwucygbl35wyq 156 29 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 156 30 Oligoarray Oligoarray NNP work_wtnfwgpzqnfabpwucygbl35wyq 156 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 156 32 CombiMATRIX CombiMATRIX NNP work_wtnfwgpzqnfabpwucygbl35wyq 156 33 Diagnostics Diagnostics NNPS work_wtnfwgpzqnfabpwucygbl35wyq 156 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 156 35 Irvine Irvine NNP work_wtnfwgpzqnfabpwucygbl35wyq 156 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 156 37 California California NNP work_wtnfwgpzqnfabpwucygbl35wyq 156 38 , , , work_wtnfwgpzqnfabpwucygbl35wyq 156 39 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 156 40 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 156 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 157 1 Given give VBN work_wtnfwgpzqnfabpwucygbl35wyq 157 2 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 157 3 high high JJ work_wtnfwgpzqnfabpwucygbl35wyq 157 4 recurrence recurrence NN work_wtnfwgpzqnfabpwucygbl35wyq 157 5 rate rate NN work_wtnfwgpzqnfabpwucygbl35wyq 157 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 157 7 degree degree NN work_wtnfwgpzqnfabpwucygbl35wyq 157 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 157 9 similarity similarity NN work_wtnfwgpzqnfabpwucygbl35wyq 157 10 between between IN work_wtnfwgpzqnfabpwucygbl35wyq 157 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 157 12 affected affected JJ work_wtnfwgpzqnfabpwucygbl35wyq 157 13 children child NNS work_wtnfwgpzqnfabpwucygbl35wyq 157 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 157 15 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 157 16 suspected suspect VBD work_wtnfwgpzqnfabpwucygbl35wyq 157 17 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 157 18 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 157 19 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 157 20 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 157 21 aetiology aetiology NN work_wtnfwgpzqnfabpwucygbl35wyq 157 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 157 23 probably probably RB work_wtnfwgpzqnfabpwucygbl35wyq 157 24 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 157 25 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 157 26 inheritance inheritance NN work_wtnfwgpzqnfabpwucygbl35wyq 157 27 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 157 28 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 157 29 ancestral ancestral JJ work_wtnfwgpzqnfabpwucygbl35wyq 157 30 Mennonite Mennonite NNP work_wtnfwgpzqnfabpwucygbl35wyq 157 31 founder founder NN work_wtnfwgpzqnfabpwucygbl35wyq 157 32 allele allele NNP work_wtnfwgpzqnfabpwucygbl35wyq 157 33 . . . work_wtnfwgpzqnfabpwucygbl35wyq 158 1 Given give VBN work_wtnfwgpzqnfabpwucygbl35wyq 158 2 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 158 3 expectation expectation NN work_wtnfwgpzqnfabpwucygbl35wyq 158 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 158 5 either either DT work_wtnfwgpzqnfabpwucygbl35wyq 158 6 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 158 7 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 158 8 descent descent NN work_wtnfwgpzqnfabpwucygbl35wyq 158 9 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 158 10 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 158 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 158 12 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 158 13 inheritance inheritance NN work_wtnfwgpzqnfabpwucygbl35wyq 158 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 158 15 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 158 16 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 158 17 SNP SNP NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 18 genotyping genotype VBG work_wtnfwgpzqnfabpwucygbl35wyq 158 19 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 158 20 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 158 21 Table table NN work_wtnfwgpzqnfabpwucygbl35wyq 158 22 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 23 Clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 24 spectrum spectrum NN work_wtnfwgpzqnfabpwucygbl35wyq 158 25 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 158 26 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 27 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 158 28 Article Article NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 29 Hamby Hamby NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 30 et et FW work_wtnfwgpzqnfabpwucygbl35wyq 158 31 al26 al26 NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 32 Hamby Hamby NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 33 et et FW work_wtnfwgpzqnfabpwucygbl35wyq 158 34 al26 al26 IN work_wtnfwgpzqnfabpwucygbl35wyq 158 35 Strauss Strauss NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 36 et et NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 37 al27 al27 NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 38 Bendon Bendon NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 39 et et FW work_wtnfwgpzqnfabpwucygbl35wyq 158 40 al24 al24 NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 41 Bendon Bendon NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 42 et et FW work_wtnfwgpzqnfabpwucygbl35wyq 158 43 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 44 24 24 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 45 Gschwendtner Gschwendtner NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 46 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 158 47 al25 al25 NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 48 Chu Chu NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 49 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 158 50 al28 al28 NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 51 Chu Chu NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 52 et et NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 53 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 54 28 28 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 55 Chu Chu NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 56 et et NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 57 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 58 28 28 NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 59 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 158 60 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 158 61 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 158 62 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 158 63 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 158 64 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 158 65 Patient Patient NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 66 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 68 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 69 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 70 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 71 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 72 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 73 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 74 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 75 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 76 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 77 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 78 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 79 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 80 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 81 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 82 # # $ work_wtnfwgpzqnfabpwucygbl35wyq 158 83 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 84 303 303 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 85 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 86 306 306 CD work_wtnfwgpzqnfabpwucygbl35wyq 158 87 Sex sex NN work_wtnfwgpzqnfabpwucygbl35wyq 158 88 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 89 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 90 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 91 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 92 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 93 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 94 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 95 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 96 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 97 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 98 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 99 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 100 Mode Mode NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 101 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 158 102 death death NN work_wtnfwgpzqnfabpwucygbl35wyq 158 103 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 104 NND NND NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 105 TA TA NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 106 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 107 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 108 TA TA NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 109 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 110 TA TA NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 111 TA TA NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 112 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 113 NND NND NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 114 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 115 Hydranencephaly Hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 116 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 117 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 118 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 119 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 120 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 121 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 122 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 123 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 124 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 125 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 126 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 127 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 128 Cerebellar Cerebellar NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 129 hypoplasia hypoplasia NN work_wtnfwgpzqnfabpwucygbl35wyq 158 130 + + CD work_wtnfwgpzqnfabpwucygbl35wyq 158 131 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 132 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 133 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 134 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 135 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 136 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 137 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 138 Multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 139 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 140 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 141 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 142 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 143 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 144 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 145 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 146 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 147 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 148 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 149 Renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 150 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 151 + + XX work_wtnfwgpzqnfabpwucygbl35wyq 158 152 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 153 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 154 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 155 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 156 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 157 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 158 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 159 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 160 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 161 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 162 Ureteral ureteral JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 163 agenesis agenesis NN work_wtnfwgpzqnfabpwucygbl35wyq 158 164 + + CD work_wtnfwgpzqnfabpwucygbl35wyq 158 165 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 166 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 167 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 168 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 169 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 170 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 171 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 172 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 173 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 174 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 175 Pulmonary Pulmonary NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 176 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 177 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 178 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 179 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 180 + + CD work_wtnfwgpzqnfabpwucygbl35wyq 158 181 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 182 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 183 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 184 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 185 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 186 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 187 Oligohydramnios oligohydramnio NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 188 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 189 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 190 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 191 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 192 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 193 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 194 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 195 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 196 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 197 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 198 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 199 Contractures contracture NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 200 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 201 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 202 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 203 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 204 ± ± CD work_wtnfwgpzqnfabpwucygbl35wyq 158 205 + + CD work_wtnfwgpzqnfabpwucygbl35wyq 158 206 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 207 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 208 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 209 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 210 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 211 Cystic cystic JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 212 hygroma hygroma NN work_wtnfwgpzqnfabpwucygbl35wyq 158 213 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 214 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 215 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 216 Redundant redundant JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 217 neck neck NN work_wtnfwgpzqnfabpwucygbl35wyq 158 218 skin skin NN work_wtnfwgpzqnfabpwucygbl35wyq 158 219 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 220 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 221 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 222 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 223 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 224 Cutaneous cutaneous JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 225 syndactyly syndactyly NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 226 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 227 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 228 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 229 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 230 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 231 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 232 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 233 Wide wide JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 234 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 235 webspace webspace NN work_wtnfwgpzqnfabpwucygbl35wyq 158 236 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 158 237 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 238 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 239 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 240 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 241 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 242 Brachydactyly Brachydactyly NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 243 + + CD work_wtnfwgpzqnfabpwucygbl35wyq 158 244 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 245 + + NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 246 Vertebral vertebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 247 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 158 248 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 249 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 250 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 158 251 NND NND NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 252 , , , work_wtnfwgpzqnfabpwucygbl35wyq 158 253 Neonatal Neonatal NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 254 death death NN work_wtnfwgpzqnfabpwucygbl35wyq 158 255 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 158 256 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 257 , , , work_wtnfwgpzqnfabpwucygbl35wyq 158 258 Stillborn Stillborn NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 259 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 158 260 TA TA NNP work_wtnfwgpzqnfabpwucygbl35wyq 158 261 , , , work_wtnfwgpzqnfabpwucygbl35wyq 158 262 Therapeutic therapeutic JJ work_wtnfwgpzqnfabpwucygbl35wyq 158 263 abortion abortion NN work_wtnfwgpzqnfabpwucygbl35wyq 158 264 . . . work_wtnfwgpzqnfabpwucygbl35wyq 159 1 494 494 CD work_wtnfwgpzqnfabpwucygbl35wyq 159 2 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 159 3   _SP work_wtnfwgpzqnfabpwucygbl35wyq 159 4 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 159 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 159 6 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 159 7   _SP work_wtnfwgpzqnfabpwucygbl35wyq 159 8 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 159 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 160 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 160 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 160 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 160 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 160 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 161 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 161 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 161 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 161 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 161 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 161 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 161 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 161 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 161 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 161 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 161 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 161 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 161 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 161 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 161 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 161 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 161 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 161 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 161 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 161 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 161 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 161 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 161 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 161 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 161 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 161 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 161 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 161 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 161 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 162 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 162 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 162 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 9 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 12 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 13 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 14 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 15 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 162 16 candidate candidate NN work_wtnfwgpzqnfabpwucygbl35wyq 162 17 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 162 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 163 1 All all DT work_wtnfwgpzqnfabpwucygbl35wyq 163 2 four four CD work_wtnfwgpzqnfabpwucygbl35wyq 163 3 siblings sibling NNS work_wtnfwgpzqnfabpwucygbl35wyq 163 4 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 163 5 multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 163 6 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 163 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 163 8 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 163 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 164 1 Total total JJ work_wtnfwgpzqnfabpwucygbl35wyq 164 2 levels level NNS work_wtnfwgpzqnfabpwucygbl35wyq 164 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 164 4 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 164 5 ranged range VBD work_wtnfwgpzqnfabpwucygbl35wyq 164 6 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 164 7 2.5 2.5 CD work_wtnfwgpzqnfabpwucygbl35wyq 164 8 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 164 9 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 164 10 4.0 4.0 CD work_wtnfwgpzqnfabpwucygbl35wyq 164 11 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 164 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 164 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 164 14 genome genome NN work_wtnfwgpzqnfabpwucygbl35wyq 164 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 164 16 supporting support VBG work_wtnfwgpzqnfabpwucygbl35wyq 164 17 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 164 18 suspicion suspicion NN work_wtnfwgpzqnfabpwucygbl35wyq 164 19 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 164 20 distant distant JJ work_wtnfwgpzqnfabpwucygbl35wyq 164 21 relatedness relatedness NN work_wtnfwgpzqnfabpwucygbl35wyq 164 22 due due JJ work_wtnfwgpzqnfabpwucygbl35wyq 164 23 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 164 24 founder founder NN work_wtnfwgpzqnfabpwucygbl35wyq 164 25 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 164 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 165 1 One one CD work_wtnfwgpzqnfabpwucygbl35wyq 165 2 region region NN work_wtnfwgpzqnfabpwucygbl35wyq 165 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 165 4 9.4 9.4 CD work_wtnfwgpzqnfabpwucygbl35wyq 165 5 Mb Mb NNS work_wtnfwgpzqnfabpwucygbl35wyq 165 6 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 165 7 chromosome chromosome NN work_wtnfwgpzqnfabpwucygbl35wyq 165 8 10 10 CD work_wtnfwgpzqnfabpwucygbl35wyq 165 9 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 165 10 segregation segregation NN work_wtnfwgpzqnfabpwucygbl35wyq 165 11 consistent consistent JJ work_wtnfwgpzqnfabpwucygbl35wyq 165 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 165 13 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 165 14 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 165 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 165 16 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 165 17 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 165 18 model model NN work_wtnfwgpzqnfabpwucygbl35wyq 165 19 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 165 20 figure figure NNP work_wtnfwgpzqnfabpwucygbl35wyq 165 21 2A 2A NNP work_wtnfwgpzqnfabpwucygbl35wyq 165 22 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 165 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 166 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 166 2 addition addition NN work_wtnfwgpzqnfabpwucygbl35wyq 166 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 166 4 there there EX work_wtnfwgpzqnfabpwucygbl35wyq 166 5 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 166 6 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 166 7 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 166 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 166 9 28.7 28.7 CD work_wtnfwgpzqnfabpwucygbl35wyq 166 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 166 11 3.2 3.2 CD work_wtnfwgpzqnfabpwucygbl35wyq 166 12 Mb Mb NNP work_wtnfwgpzqnfabpwucygbl35wyq 166 13 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 166 14 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 166 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 166 16 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 166 17 chromo- chromo- NN work_wtnfwgpzqnfabpwucygbl35wyq 166 18 some some DT work_wtnfwgpzqnfabpwucygbl35wyq 166 19 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 166 20 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 166 21 segregation segregation NN work_wtnfwgpzqnfabpwucygbl35wyq 166 22 consistent consistent JJ work_wtnfwgpzqnfabpwucygbl35wyq 166 23 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 166 24 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 166 25 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 166 26 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 166 27 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 166 28 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 166 29 model model NN work_wtnfwgpzqnfabpwucygbl35wyq 166 30 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 166 31 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 166 32 2B 2B NNS work_wtnfwgpzqnfabpwucygbl35wyq 166 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 166 34 . . . work_wtnfwgpzqnfabpwucygbl35wyq 167 1 Next next RB work_wtnfwgpzqnfabpwucygbl35wyq 167 2 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 167 3 performed perform VBD work_wtnfwgpzqnfabpwucygbl35wyq 167 4 exome exome JJ work_wtnfwgpzqnfabpwucygbl35wyq 167 5 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 167 6 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 167 7 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 167 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 167 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 167 10 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 167 11 infants infant NNS work_wtnfwgpzqnfabpwucygbl35wyq 167 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 168 1 Mean mean JJ work_wtnfwgpzqnfabpwucygbl35wyq 168 2 CCDS ccds NN work_wtnfwgpzqnfabpwucygbl35wyq 168 3 coverage coverage NN work_wtnfwgpzqnfabpwucygbl35wyq 168 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 168 5 141X 141x CD work_wtnfwgpzqnfabpwucygbl35wyq 168 6 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 168 7 92 92 CD work_wtnfwgpzqnfabpwucygbl35wyq 168 8 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 168 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 168 10 bases basis NNS work_wtnfwgpzqnfabpwucygbl35wyq 168 11 covered cover VBN work_wtnfwgpzqnfabpwucygbl35wyq 168 12 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 168 13 > > NNP work_wtnfwgpzqnfabpwucygbl35wyq 168 14 20 20 CD work_wtnfwgpzqnfabpwucygbl35wyq 168 15 reads read NNS work_wtnfwgpzqnfabpwucygbl35wyq 168 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 169 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 169 2 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 169 3 ∼147 ∼147 NNP work_wtnfwgpzqnfabpwucygbl35wyq 169 4 000 000 CD work_wtnfwgpzqnfabpwucygbl35wyq 169 5 variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 169 6 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 169 7 exceeded exceed VBD work_wtnfwgpzqnfabpwucygbl35wyq 169 8 quality quality NN work_wtnfwgpzqnfabpwucygbl35wyq 169 9 thresholds threshold NNS work_wtnfwgpzqnfabpwucygbl35wyq 169 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 170 1 Filtering filter VBG work_wtnfwgpzqnfabpwucygbl35wyq 170 2 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 170 3 rare rare JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 4 non non JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 5 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 6 synonymous/ synonymous/ JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 7 splice splice NN work_wtnfwgpzqnfabpwucygbl35wyq 170 8 variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 170 9 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 10 < < XX work_wtnfwgpzqnfabpwucygbl35wyq 170 11 0.1 0.1 CD work_wtnfwgpzqnfabpwucygbl35wyq 170 12 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 170 13 based base VBN work_wtnfwgpzqnfabpwucygbl35wyq 170 14 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 170 15 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 16 frequencies frequency NNS work_wtnfwgpzqnfabpwucygbl35wyq 170 17 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 170 18 publicly publicly RB work_wtnfwgpzqnfabpwucygbl35wyq 170 19 available available JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 20 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 170 21 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 170 22 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 170 23 house house NN work_wtnfwgpzqnfabpwucygbl35wyq 170 24 exome exome NN work_wtnfwgpzqnfabpwucygbl35wyq 170 25 datasets dataset NNS work_wtnfwgpzqnfabpwucygbl35wyq 170 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 27 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 170 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 170 29 candidate candidate NN work_wtnfwgpzqnfabpwucygbl35wyq 170 30 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 170 31 identified identify VBN work_wtnfwgpzqnfabpwucygbl35wyq 170 32 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 33 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 170 34 2A 2a NN work_wtnfwgpzqnfabpwucygbl35wyq 170 35 , , , work_wtnfwgpzqnfabpwucygbl35wyq 170 36 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 170 37 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 38 , , , work_wtnfwgpzqnfabpwucygbl35wyq 170 39 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 170 40 narrowed narrow VBD work_wtnfwgpzqnfabpwucygbl35wyq 170 41 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 170 42 list list NN work_wtnfwgpzqnfabpwucygbl35wyq 170 43 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 170 44 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 170 45 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 46 candi- candi- NN work_wtnfwgpzqnfabpwucygbl35wyq 170 47 date date NN work_wtnfwgpzqnfabpwucygbl35wyq 170 48 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 49 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 170 50 2C 2c NN work_wtnfwgpzqnfabpwucygbl35wyq 170 51 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 52 : : : work_wtnfwgpzqnfabpwucygbl35wyq 170 53 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 170 54 homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 170 55 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 170 56 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 170 57 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 170 58 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 170 59 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 60 rs201430235 rs201430235 NNP work_wtnfwgpzqnfabpwucygbl35wyq 170 61 , , , work_wtnfwgpzqnfabpwucygbl35wyq 170 62 c.1274C c.1274c XX work_wtnfwgpzqnfabpwucygbl35wyq 170 63 > > FW work_wtnfwgpzqnfabpwucygbl35wyq 170 64 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 170 65 , , , work_wtnfwgpzqnfabpwucygbl35wyq 170 66 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 170 67 . . . work_wtnfwgpzqnfabpwucygbl35wyq 170 68 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 170 69 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 70 NM_001127182.1 NM_001127182.1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 170 71 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 72 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 170 73 . . . work_wtnfwgpzqnfabpwucygbl35wyq 171 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 171 2 variant variant NN work_wtnfwgpzqnfabpwucygbl35wyq 171 3 has have VBZ work_wtnfwgpzqnfabpwucygbl35wyq 171 4 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 171 5 reported report VBN work_wtnfwgpzqnfabpwucygbl35wyq 171 6 previously previously RB work_wtnfwgpzqnfabpwucygbl35wyq 171 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 171 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 171 9 large large JJ work_wtnfwgpzqnfabpwucygbl35wyq 171 10 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 171 11 scale scale NN work_wtnfwgpzqnfabpwucygbl35wyq 171 12 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 171 13 identi- identi- NNP work_wtnfwgpzqnfabpwucygbl35wyq 171 14 fication fication NN work_wtnfwgpzqnfabpwucygbl35wyq 171 15 project project NN work_wtnfwgpzqnfabpwucygbl35wyq 171 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 171 17 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 171 18 separate separate JJ work_wtnfwgpzqnfabpwucygbl35wyq 171 19 individuals individual NNS work_wtnfwgpzqnfabpwucygbl35wyq 171 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 171 21 both both DT work_wtnfwgpzqnfabpwucygbl35wyq 171 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 171 23 whom whom WP work_wtnfwgpzqnfabpwucygbl35wyq 171 24 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 171 25 heterozygous heterozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 171 26 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 171 27 http://genome.sph.umich.edu/wiki/Exome_Chip http://genome.sph.umich.edu/wiki/Exome_Chip NNP work_wtnfwgpzqnfabpwucygbl35wyq 171 28 _ _ NNP work_wtnfwgpzqnfabpwucygbl35wyq 171 29 Design Design NNP work_wtnfwgpzqnfabpwucygbl35wyq 171 30 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 171 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 172 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 172 2 ExAC ExAC NNP work_wtnfwgpzqnfabpwucygbl35wyq 172 3 database database NN work_wtnfwgpzqnfabpwucygbl35wyq 172 4 reports report VBZ work_wtnfwgpzqnfabpwucygbl35wyq 172 5 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 172 6 allele allele NN work_wtnfwgpzqnfabpwucygbl35wyq 172 7 frequency frequency NN work_wtnfwgpzqnfabpwucygbl35wyq 172 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 172 9 0.0016 0.0016 CD work_wtnfwgpzqnfabpwucygbl35wyq 172 10 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 172 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 172 12 January January NNP work_wtnfwgpzqnfabpwucygbl35wyq 172 13 2016 2016 CD work_wtnfwgpzqnfabpwucygbl35wyq 172 14 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 172 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 173 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 2 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 3 maps map NNS work_wtnfwgpzqnfabpwucygbl35wyq 173 4 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 173 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 6 final final JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 7 exon exon NN work_wtnfwgpzqnfabpwucygbl35wyq 173 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 173 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 10 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 173 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 173 12 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 173 13 predicted predict VBN work_wtnfwgpzqnfabpwucygbl35wyq 173 14 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 173 15 escape escape VB work_wtnfwgpzqnfabpwucygbl35wyq 173 16 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 173 17 mediated mediate VBN work_wtnfwgpzqnfabpwucygbl35wyq 173 18 decay decay NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 173 20 resulting result VBG work_wtnfwgpzqnfabpwucygbl35wyq 173 21 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 173 22 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 173 23 truncation truncation NN work_wtnfwgpzqnfabpwucygbl35wyq 173 24 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 173 25 40 40 CD work_wtnfwgpzqnfabpwucygbl35wyq 173 26 amino amino JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 27 acids acid NNS work_wtnfwgpzqnfabpwucygbl35wyq 173 28 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 173 29 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 30 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 31 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 173 32 terminus.30 terminus.30 NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 33 Orthologs ortholog VBZ work_wtnfwgpzqnfabpwucygbl35wyq 173 34 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 173 35 31/32 31/32 CD work_wtnfwgpzqnfabpwucygbl35wyq 173 36 primates primate NNS work_wtnfwgpzqnfabpwucygbl35wyq 173 37 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 173 38 placental placental JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 39 mammals mammal NNS work_wtnfwgpzqnfabpwucygbl35wyq 173 40 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 173 41 conservation conservation NN work_wtnfwgpzqnfabpwucygbl35wyq 173 42 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 173 43 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 173 44 region region NN work_wtnfwgpzqnfabpwucygbl35wyq 173 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 173 46 especially especially RB work_wtnfwgpzqnfabpwucygbl35wyq 173 47 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 173 48 serine serine JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 49 residues residue NNS work_wtnfwgpzqnfabpwucygbl35wyq 173 50 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 173 51 S425 S425 NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 52 , , , work_wtnfwgpzqnfabpwucygbl35wyq 173 53 S428 S428 NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 54 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 173 55 S436 S436 NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 56 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 173 57 , , , work_wtnfwgpzqnfabpwucygbl35wyq 173 58 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 173 59 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 173 60 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 173 61 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 173 62 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 173 63 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 173 64 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 173 65 phosphory- phosphory- JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 66 lated late VBN work_wtnfwgpzqnfabpwucygbl35wyq 173 67 , , , work_wtnfwgpzqnfabpwucygbl35wyq 173 68 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 173 69 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 173 70 essential essential JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 71 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 173 72 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 73 function function NN work_wtnfwgpzqnfabpwucygbl35wyq 173 74 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 173 75 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 173 76 protein.31 protein.31 NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 77 32 32 CD work_wtnfwgpzqnfabpwucygbl35wyq 173 78 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 79 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 173 80 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 173 81 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 82 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 173 83 confirmed confirm VBD work_wtnfwgpzqnfabpwucygbl35wyq 173 84 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 173 85 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 173 86 variant variant NN work_wtnfwgpzqnfabpwucygbl35wyq 173 87 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 173 88 segregation segregation NN work_wtnfwgpzqnfabpwucygbl35wyq 173 89 consistent consistent JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 90 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 173 91 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 92 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 173 93 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 94 inherit- inherit- JJ work_wtnfwgpzqnfabpwucygbl35wyq 173 95 ance ance NN work_wtnfwgpzqnfabpwucygbl35wyq 173 96 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 173 97 figure figure NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 98 2D 2D NNP work_wtnfwgpzqnfabpwucygbl35wyq 173 99 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 173 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 174 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 174 2 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 174 3 effort effort NN work_wtnfwgpzqnfabpwucygbl35wyq 174 4 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 174 5 identify identify VB work_wtnfwgpzqnfabpwucygbl35wyq 174 6 additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 174 7 variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 174 8 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 174 9 could could MD work_wtnfwgpzqnfabpwucygbl35wyq 174 10 contribute contribute VB work_wtnfwgpzqnfabpwucygbl35wyq 174 11 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 174 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 174 13 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 174 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 174 15 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 174 16 analysed analyse VBD work_wtnfwgpzqnfabpwucygbl35wyq 174 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 174 18 exome exome JJ work_wtnfwgpzqnfabpwucygbl35wyq 174 19 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 174 20 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 174 21 relaxed relaxed JJ work_wtnfwgpzqnfabpwucygbl35wyq 174 22 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 174 23 filtering filtering NN work_wtnfwgpzqnfabpwucygbl35wyq 174 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 174 25 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 174 26 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 174 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 174 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 175 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 175 2 included include VBD work_wtnfwgpzqnfabpwucygbl35wyq 175 3 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 175 4 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 175 5 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 175 6 segregate segregate VBP work_wtnfwgpzqnfabpwucygbl35wyq 175 7 under under IN work_wtnfwgpzqnfabpwucygbl35wyq 175 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 175 9 compound compound JJ work_wtnfwgpzqnfabpwucygbl35wyq 175 10 heterozygous heterozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 175 11 model model NN work_wtnfwgpzqnfabpwucygbl35wyq 175 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 175 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 175 14 frequency frequency NN work_wtnfwgpzqnfabpwucygbl35wyq 175 15 cut cut VBN work_wtnfwgpzqnfabpwucygbl35wyq 175 16 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 175 17 offs off NNS work_wtnfwgpzqnfabpwucygbl35wyq 175 18 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 175 19 increased increase VBN work_wtnfwgpzqnfabpwucygbl35wyq 175 20 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 175 21 < < XX work_wtnfwgpzqnfabpwucygbl35wyq 175 22 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 175 23 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 175 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 176 1 Under under IN work_wtnfwgpzqnfabpwucygbl35wyq 176 2 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 176 3 criteria criterion NNS work_wtnfwgpzqnfabpwucygbl35wyq 176 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 176 5 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 176 6 only only RB work_wtnfwgpzqnfabpwucygbl35wyq 176 7 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 176 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 176 9 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 176 10 additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 176 11 candidate candidate NN work_wtnfwgpzqnfabpwucygbl35wyq 176 12 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 176 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 176 14 R3HCC1L R3HCC1L NNP work_wtnfwgpzqnfabpwucygbl35wyq 176 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 176 16 homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 176 17 rs147674187 rs147674187 FW work_wtnfwgpzqnfabpwucygbl35wyq 176 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 176 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 177 1 Although although IN work_wtnfwgpzqnfabpwucygbl35wyq 177 2 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 177 3 can can MD work_wtnfwgpzqnfabpwucygbl35wyq 177 4 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 177 5 exclude exclude VB work_wtnfwgpzqnfabpwucygbl35wyq 177 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 177 7 possibility possibility NN work_wtnfwgpzqnfabpwucygbl35wyq 177 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 177 9 involvement involvement NN work_wtnfwgpzqnfabpwucygbl35wyq 177 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 177 11 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 177 12 has have VBZ work_wtnfwgpzqnfabpwucygbl35wyq 177 13 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 177 14 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 177 15 implicated implicate VBN work_wtnfwgpzqnfabpwucygbl35wyq 177 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 177 17 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 177 18 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 177 19 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 177 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 177 21 variant variant NN work_wtnfwgpzqnfabpwucygbl35wyq 177 22 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 177 23 unlikely unlikely JJ work_wtnfwgpzqnfabpwucygbl35wyq 177 24 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 177 25 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 177 26 pathogenic pathogenic JJ work_wtnfwgpzqnfabpwucygbl35wyq 177 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 177 28 CADD CADD NNS work_wtnfwgpzqnfabpwucygbl35wyq 177 29 score score VBP work_wtnfwgpzqnfabpwucygbl35wyq 177 30 1.5).33 1.5).33 CD work_wtnfwgpzqnfabpwucygbl35wyq 177 31 Thus thus RB work_wtnfwgpzqnfabpwucygbl35wyq 177 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 177 33 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 177 34 remains remain VBZ work_wtnfwgpzqnfabpwucygbl35wyq 177 35 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 177 36 most most RBS work_wtnfwgpzqnfabpwucygbl35wyq 177 37 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 177 38 candi- candi- JJ work_wtnfwgpzqnfabpwucygbl35wyq 177 39 date date NN work_wtnfwgpzqnfabpwucygbl35wyq 177 40 molecular molecular JJ work_wtnfwgpzqnfabpwucygbl35wyq 177 41 driver driver NN work_wtnfwgpzqnfabpwucygbl35wyq 177 42 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 177 43 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 177 44 . . . work_wtnfwgpzqnfabpwucygbl35wyq 178 1 Figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 178 2 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 178 3 Genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 178 4 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 178 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 178 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 178 7 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 178 8 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 178 9 pedigree pedigree NN work_wtnfwgpzqnfabpwucygbl35wyq 178 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 179 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 179 2 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 179 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 179 4 Circular circular JJ work_wtnfwgpzqnfabpwucygbl35wyq 179 5 ideogram ideogram NN work_wtnfwgpzqnfabpwucygbl35wyq 179 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 179 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 179 8 genome genome JJ work_wtnfwgpzqnfabpwucygbl35wyq 179 9 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 179 10 Agile Agile NNP work_wtnfwgpzqnfabpwucygbl35wyq 179 11 MultiIdeogram MultiIdeogram NNP work_wtnfwgpzqnfabpwucygbl35wyq 179 12 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 179 13 http://dna.leeds.ac.uk/ http://dna.leeds.ac.uk/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 179 14 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 179 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 180 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 180 2 outer outer JJ work_wtnfwgpzqnfabpwucygbl35wyq 180 3 circle circle NN work_wtnfwgpzqnfabpwucygbl35wyq 180 4 represents represent VBZ work_wtnfwgpzqnfabpwucygbl35wyq 180 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 180 6 ideograms ideogram NNS work_wtnfwgpzqnfabpwucygbl35wyq 180 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 180 8 chromosomes chromosome NNS work_wtnfwgpzqnfabpwucygbl35wyq 180 9 1–22 1–22 NNP work_wtnfwgpzqnfabpwucygbl35wyq 180 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 181 1 Each each DT work_wtnfwgpzqnfabpwucygbl35wyq 181 2 inner inner JJ work_wtnfwgpzqnfabpwucygbl35wyq 181 3 circle circle NN work_wtnfwgpzqnfabpwucygbl35wyq 181 4 represents represent VBZ work_wtnfwgpzqnfabpwucygbl35wyq 181 5 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 181 6 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 181 7 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 181 8 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 181 9 individual individual NN work_wtnfwgpzqnfabpwucygbl35wyq 181 10 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 181 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 181 12 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 181 13 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 181 14 marked mark VBN work_wtnfwgpzqnfabpwucygbl35wyq 181 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 182 1 Homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 182 2 blocks block NNS work_wtnfwgpzqnfabpwucygbl35wyq 182 3 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 182 4 coloured colour VBN work_wtnfwgpzqnfabpwucygbl35wyq 182 5 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 182 6 either either DT work_wtnfwgpzqnfabpwucygbl35wyq 182 7 grey grey NNP work_wtnfwgpzqnfabpwucygbl35wyq 182 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 182 9 unaffected unaffected NNP work_wtnfwgpzqnfabpwucygbl35wyq 182 10 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 182 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 182 12 red red NNP work_wtnfwgpzqnfabpwucygbl35wyq 182 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 182 14 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 182 15 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 182 16 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 182 17 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 182 18 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 182 19 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 182 20 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 182 21 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 182 22 siblings sibling NNS work_wtnfwgpzqnfabpwucygbl35wyq 182 23 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 182 24 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 182 25 blue blue NNP work_wtnfwgpzqnfabpwucygbl35wyq 182 26 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 182 27 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 182 28 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 182 29 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 182 30 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 182 31 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 182 32 siblings sibling NNS work_wtnfwgpzqnfabpwucygbl35wyq 182 33 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 182 34 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 182 35 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 182 36 unaffected unaffected JJ work_wtnfwgpzqnfabpwucygbl35wyq 182 37 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 182 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 183 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 183 2 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 183 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 183 4 Segregation segregation NN work_wtnfwgpzqnfabpwucygbl35wyq 183 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 183 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 183 7 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 183 8 chromosome chromosome NN work_wtnfwgpzqnfabpwucygbl35wyq 183 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 183 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 183 11 four four CD work_wtnfwgpzqnfabpwucygbl35wyq 183 12 male male JJ work_wtnfwgpzqnfabpwucygbl35wyq 183 13 siblings sibling NNS work_wtnfwgpzqnfabpwucygbl35wyq 183 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 184 1 Areas area NNS work_wtnfwgpzqnfabpwucygbl35wyq 184 2 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 184 3 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 184 4 common common JJ work_wtnfwgpzqnfabpwucygbl35wyq 184 5 among among IN work_wtnfwgpzqnfabpwucygbl35wyq 184 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 184 7 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 184 8 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 184 9 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 184 10 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 184 11 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 184 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 184 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 184 14 unaffected unaffected JJ work_wtnfwgpzqnfabpwucygbl35wyq 184 15 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 184 16 highlighted highlight VBN work_wtnfwgpzqnfabpwucygbl35wyq 184 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 185 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 185 2 C c NN work_wtnfwgpzqnfabpwucygbl35wyq 185 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 185 4 Exome Exome NNP work_wtnfwgpzqnfabpwucygbl35wyq 185 5 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 185 6 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 185 7 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 185 8 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 185 9 306 306 CD work_wtnfwgpzqnfabpwucygbl35wyq 185 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 186 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 186 2 filtering filter VBG work_wtnfwgpzqnfabpwucygbl35wyq 186 3 parameters parameter NNS work_wtnfwgpzqnfabpwucygbl35wyq 186 4 used use VBD work_wtnfwgpzqnfabpwucygbl35wyq 186 5 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 186 6 sort sort VB work_wtnfwgpzqnfabpwucygbl35wyq 186 7 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 186 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 186 9 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 186 10 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 186 11 set set NN work_wtnfwgpzqnfabpwucygbl35wyq 186 12 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 186 13 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 186 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 187 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 187 2 most most RBS work_wtnfwgpzqnfabpwucygbl35wyq 187 3 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 187 4 candidate candidate NN work_wtnfwgpzqnfabpwucygbl35wyq 187 5 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 187 6 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 187 7 causing cause VBG work_wtnfwgpzqnfabpwucygbl35wyq 187 8 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 187 9 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 187 10 highlighted highlight VBN work_wtnfwgpzqnfabpwucygbl35wyq 187 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 187 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 187 13 grey grey NN work_wtnfwgpzqnfabpwucygbl35wyq 187 14 rectangle rectangle NNP work_wtnfwgpzqnfabpwucygbl35wyq 187 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 188 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 188 2 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 188 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 188 4 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 188 5 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 188 6 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 188 7 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 188 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 188 9 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 188 10 variant variant NN work_wtnfwgpzqnfabpwucygbl35wyq 188 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 188 12 showing show VBG work_wtnfwgpzqnfabpwucygbl35wyq 188 13 traces trace NNS work_wtnfwgpzqnfabpwucygbl35wyq 188 14 bearing bear VBG work_wtnfwgpzqnfabpwucygbl35wyq 188 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 188 16 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 188 17 segregating segregate VBG work_wtnfwgpzqnfabpwucygbl35wyq 188 18 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 188 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 188 20 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 188 21 under under IN work_wtnfwgpzqnfabpwucygbl35wyq 188 22 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 188 23 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 188 24 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 188 25 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 188 26 paradigm paradigm NN work_wtnfwgpzqnfabpwucygbl35wyq 188 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 189 1 495Frosk 495Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 189 2   _SP work_wtnfwgpzqnfabpwucygbl35wyq 189 3 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 189 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 189 5 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 189 6   _SP work_wtnfwgpzqnfabpwucygbl35wyq 189 7 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 189 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 190 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 190 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 190 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 190 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 190 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 191 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 191 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 191 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 191 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 191 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 191 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 191 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 191 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 191 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 191 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 191 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 191 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 191 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 191 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 191 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 191 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 191 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 191 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 191 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 191 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 191 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 191 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 191 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 191 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 191 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 191 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 191 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 191 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 191 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 192 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 192 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 192 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 192 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 12 http://genome.sph.umich.edu/wiki/Exome_Chip_Design http://genome.sph.umich.edu/wiki/Exome_Chip_Design NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 13 http://genome.sph.umich.edu/wiki/Exome_Chip_Design http://genome.sph.umich.edu/wiki/exome_chip_design XX work_wtnfwgpzqnfabpwucygbl35wyq 192 14 http://genome.sph.umich.edu/wiki/Exome_Chip_Design http://genome.sph.umich.edu/wiki/exome_chip_design CD work_wtnfwgpzqnfabpwucygbl35wyq 192 15 http://dna.leeds.ac.uk/ http://dna.leeds.ac.uk/ RB work_wtnfwgpzqnfabpwucygbl35wyq 192 16 http://dna.leeds.ac.uk/ http://dna.leeds.ac.uk/ JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 17 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 18 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 19 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 192 20 Most most RBS work_wtnfwgpzqnfabpwucygbl35wyq 192 21 reported report VBD work_wtnfwgpzqnfabpwucygbl35wyq 192 22 functional functional JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 23 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 24 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 192 25 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 26 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 192 27 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 192 28 per- per- RB work_wtnfwgpzqnfabpwucygbl35wyq 192 29 formed form VBN work_wtnfwgpzqnfabpwucygbl35wyq 192 30 either either CC work_wtnfwgpzqnfabpwucygbl35wyq 192 31 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 192 32 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 192 33 culture culture NN work_wtnfwgpzqnfabpwucygbl35wyq 192 34 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 192 35 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 192 36 tumour tumour NN work_wtnfwgpzqnfabpwucygbl35wyq 192 37 tissue.31 tissue.31 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 38 32 32 CD work_wtnfwgpzqnfabpwucygbl35wyq 192 39 34–38 34–38 NN work_wtnfwgpzqnfabpwucygbl35wyq 192 40 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 192 41 investigate investigate VB work_wtnfwgpzqnfabpwucygbl35wyq 192 42 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 192 43 spatiotemporal spatiotemporal JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 44 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 192 45 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 192 46 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 47 , , , work_wtnfwgpzqnfabpwucygbl35wyq 192 48 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 192 49 emphasis emphasis NN work_wtnfwgpzqnfabpwucygbl35wyq 192 50 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 192 51 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 192 52 developing develop VBG work_wtnfwgpzqnfabpwucygbl35wyq 192 53 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 54 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 192 55 , , , work_wtnfwgpzqnfabpwucygbl35wyq 192 56 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 192 57 interrogated interrogate VBD work_wtnfwgpzqnfabpwucygbl35wyq 192 58 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 192 59 Brainspan Brainspan NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 60 transcriptome transcriptome DT work_wtnfwgpzqnfabpwucygbl35wyq 192 61 database database NN work_wtnfwgpzqnfabpwucygbl35wyq 192 62 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 192 63 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 64 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 65 levels level NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 66 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 192 67 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 192 68 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 69 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 192 70 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 192 71 different different JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 72 time time NN work_wtnfwgpzqnfabpwucygbl35wyq 192 73 points point NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 74 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 192 75 gestation.39 gestation.39 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 76 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 192 77 highest high JJS work_wtnfwgpzqnfabpwucygbl35wyq 192 78 levels level NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 79 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 192 80 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 192 81 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 192 82 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 192 83 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 192 84 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 85 8 8 CD work_wtnfwgpzqnfabpwucygbl35wyq 192 86 – – : work_wtnfwgpzqnfabpwucygbl35wyq 192 87 12 12 CD work_wtnfwgpzqnfabpwucygbl35wyq 192 88 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 89 gestation gestation NN work_wtnfwgpzqnfabpwucygbl35wyq 192 90 , , , work_wtnfwgpzqnfabpwucygbl35wyq 192 91 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 192 92 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 192 93 decline decline NN work_wtnfwgpzqnfabpwucygbl35wyq 192 94 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 192 95 16 16 CD work_wtnfwgpzqnfabpwucygbl35wyq 192 96 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 97 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 192 98 minimally minimally RB work_wtnfwgpzqnfabpwucygbl35wyq 192 99 detectable detectable JJ work_wtnfwgpzqnfabpwucygbl35wyq 192 100 levels level NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 101 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 192 102 37 37 CD work_wtnfwgpzqnfabpwucygbl35wyq 192 103 weeks week NNS work_wtnfwgpzqnfabpwucygbl35wyq 192 104 , , , work_wtnfwgpzqnfabpwucygbl35wyq 192 105 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 192 106 continued continue VBD work_wtnfwgpzqnfabpwucygbl35wyq 192 107 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 192 108 adulthood adulthood NN work_wtnfwgpzqnfabpwucygbl35wyq 192 109 . . . work_wtnfwgpzqnfabpwucygbl35wyq 193 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 193 2 corresponds correspond VBZ work_wtnfwgpzqnfabpwucygbl35wyq 193 3 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 193 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 193 5 timing timing NN work_wtnfwgpzqnfabpwucygbl35wyq 193 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 193 7 asymmetric asymmetric JJ work_wtnfwgpzqnfabpwucygbl35wyq 193 8 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 193 9 division division NN work_wtnfwgpzqnfabpwucygbl35wyq 193 10 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 193 11 produce produce VB work_wtnfwgpzqnfabpwucygbl35wyq 193 12 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 193 13 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 193 14 neural neural JJ work_wtnfwgpzqnfabpwucygbl35wyq 193 15 progenitor progenitor NN work_wtnfwgpzqnfabpwucygbl35wyq 193 16 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 193 17 destined destine VBN work_wtnfwgpzqnfabpwucygbl35wyq 193 18 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 193 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 193 20 neocortex neocortex NN work_wtnfwgpzqnfabpwucygbl35wyq 193 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 193 22 basal basal NN work_wtnfwgpzqnfabpwucygbl35wyq 193 23 nuclei.40 nuclei.40 NNP work_wtnfwgpzqnfabpwucygbl35wyq 193 24 Structures Structures NNP work_wtnfwgpzqnfabpwucygbl35wyq 193 25 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 193 26 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 193 27 highest high JJS work_wtnfwgpzqnfabpwucygbl35wyq 193 28 expres- expres- NNS work_wtnfwgpzqnfabpwucygbl35wyq 193 29 sion sion NN work_wtnfwgpzqnfabpwucygbl35wyq 193 30 included include VBD work_wtnfwgpzqnfabpwucygbl35wyq 193 31 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 193 32 ganglionic ganglionic JJ work_wtnfwgpzqnfabpwucygbl35wyq 193 33 eminence eminence NN work_wtnfwgpzqnfabpwucygbl35wyq 193 34 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 193 35 occipital occipital JJ work_wtnfwgpzqnfabpwucygbl35wyq 193 36 cortex cortex NN work_wtnfwgpzqnfabpwucygbl35wyq 193 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 193 38 fol- fol- NN work_wtnfwgpzqnfabpwucygbl35wyq 193 39 lowed low VBN work_wtnfwgpzqnfabpwucygbl35wyq 193 40 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 193 41 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 193 42 dorsolateral dorsolateral NNP work_wtnfwgpzqnfabpwucygbl35wyq 193 43 prefrontal prefrontal NNP work_wtnfwgpzqnfabpwucygbl35wyq 193 44 cortex cortex NNP work_wtnfwgpzqnfabpwucygbl35wyq 193 45 . . . work_wtnfwgpzqnfabpwucygbl35wyq 194 1 Lowest low JJS work_wtnfwgpzqnfabpwucygbl35wyq 194 2 levels level NNS work_wtnfwgpzqnfabpwucygbl35wyq 194 3 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 194 4 approximately approximately RB work_wtnfwgpzqnfabpwucygbl35wyq 194 5 1/3 1/3 CD work_wtnfwgpzqnfabpwucygbl35wyq 194 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 194 7 highest high JJS work_wtnfwgpzqnfabpwucygbl35wyq 194 8 values value NNS work_wtnfwgpzqnfabpwucygbl35wyq 194 9 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 194 10 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 194 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 194 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 194 13 cerebellum cerebellum NN work_wtnfwgpzqnfabpwucygbl35wyq 194 14 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 194 15 inferolateral inferolateral JJ work_wtnfwgpzqnfabpwucygbl35wyq 194 16 temporal temporal JJ work_wtnfwgpzqnfabpwucygbl35wyq 194 17 cortex cortex NN work_wtnfwgpzqnfabpwucygbl35wyq 194 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 194 19 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 194 20 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 194 21 note note VBP work_wtnfwgpzqnfabpwucygbl35wyq 194 22 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 194 23 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 194 24 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 194 25 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 194 26 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 194 27 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 194 28 spared spare VBN work_wtnfwgpzqnfabpwucygbl35wyq 194 29 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 194 30 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 194 31 major major JJ work_wtnfwgpzqnfabpwucygbl35wyq 194 32 destructive destructive JJ work_wtnfwgpzqnfabpwucygbl35wyq 194 33 process process NN work_wtnfwgpzqnfabpwucygbl35wyq 194 34 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 194 35 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 194 36 patients patient NNS work_wtnfwgpzqnfabpwucygbl35wyq 194 37 . . . work_wtnfwgpzqnfabpwucygbl35wyq 195 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 195 2 derived derive VBD work_wtnfwgpzqnfabpwucygbl35wyq 195 3 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 195 4 fibroblast fibroblast JJ work_wtnfwgpzqnfabpwucygbl35wyq 195 5 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 195 6 line line NN work_wtnfwgpzqnfabpwucygbl35wyq 195 7 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 195 8 infant infant NN work_wtnfwgpzqnfabpwucygbl35wyq 195 9 305 305 CD work_wtnfwgpzqnfabpwucygbl35wyq 195 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 195 11 studied study VBD work_wtnfwgpzqnfabpwucygbl35wyq 195 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 195 13 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 195 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 195 15 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 195 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 195 17 figure figure NNP work_wtnfwgpzqnfabpwucygbl35wyq 195 18 3A 3A NNP work_wtnfwgpzqnfabpwucygbl35wyq 195 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 195 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 196 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 196 2 conducted conduct VBD work_wtnfwgpzqnfabpwucygbl35wyq 196 3 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 196 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 196 5 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 196 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 196 7 detected detect VBD work_wtnfwgpzqnfabpwucygbl35wyq 196 8 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 196 9 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 196 10 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 196 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 196 12 although although IN work_wtnfwgpzqnfabpwucygbl35wyq 196 13 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 196 14 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 196 15 decreased decrease VBN work_wtnfwgpzqnfabpwucygbl35wyq 196 16 compared compare VBN work_wtnfwgpzqnfabpwucygbl35wyq 196 17 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 196 18 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 196 19 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 196 20 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 196 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 196 22 suggesting suggest VBG work_wtnfwgpzqnfabpwucygbl35wyq 196 23 reduced reduce VBN work_wtnfwgpzqnfabpwucygbl35wyq 196 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 196 25 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 196 26 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 196 27 extinguished extinguish VBN work_wtnfwgpzqnfabpwucygbl35wyq 196 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 196 29 mRNA mrna VB work_wtnfwgpzqnfabpwucygbl35wyq 196 30 stability stability NN work_wtnfwgpzqnfabpwucygbl35wyq 196 31 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 196 32 figure figure VB work_wtnfwgpzqnfabpwucygbl35wyq 196 33 3B 3B NNP work_wtnfwgpzqnfabpwucygbl35wyq 196 34 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 196 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 197 1 There there EX work_wtnfwgpzqnfabpwucygbl35wyq 197 2 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 197 3 no no DT work_wtnfwgpzqnfabpwucygbl35wyq 197 4 evidence evidence NN work_wtnfwgpzqnfabpwucygbl35wyq 197 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 197 6 splicing splicing NN work_wtnfwgpzqnfabpwucygbl35wyq 197 7 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 197 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 197 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 197 10 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 197 11 transcript transcript NN work_wtnfwgpzqnfabpwucygbl35wyq 197 12 could could MD work_wtnfwgpzqnfabpwucygbl35wyq 197 13 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 197 14 detected detect VBN work_wtnfwgpzqnfabpwucygbl35wyq 197 15 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 197 16 sequencing sequence VBG work_wtnfwgpzqnfabpwucygbl35wyq 197 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 197 18 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 197 19 3C 3c NN work_wtnfwgpzqnfabpwucygbl35wyq 197 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 197 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 198 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 198 2 attempted attempt VBD work_wtnfwgpzqnfabpwucygbl35wyq 198 3 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 198 4 perform perform VB work_wtnfwgpzqnfabpwucygbl35wyq 198 5 immunohistochemical immunohistochemical JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 198 7 western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 8 blot blot NN work_wtnfwgpzqnfabpwucygbl35wyq 198 9 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 198 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 198 11 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 198 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 198 13 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 14 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 15 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 198 16 as as RB work_wtnfwgpzqnfabpwucygbl35wyq 198 17 well well RB work_wtnfwgpzqnfabpwucygbl35wyq 198 18 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 198 19 samples sample NNS work_wtnfwgpzqnfabpwucygbl35wyq 198 20 obtained obtain VBN work_wtnfwgpzqnfabpwucygbl35wyq 198 21 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 198 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 198 23 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 198 24 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 198 25 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 198 26 autopsy autopsy JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 27 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 198 28 multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 29 commercial commercial JJ work_wtnfwgpzqnfabpwucygbl35wyq 198 30 antibodies antibody NNS work_wtnfwgpzqnfabpwucygbl35wyq 198 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 199 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 199 2 had have VBD work_wtnfwgpzqnfabpwucygbl35wyq 199 3 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 199 4 difficulty difficulty NN work_wtnfwgpzqnfabpwucygbl35wyq 199 5 obtaining obtain VBG work_wtnfwgpzqnfabpwucygbl35wyq 199 6 reliable reliable JJ work_wtnfwgpzqnfabpwucygbl35wyq 199 7 staining staining NN work_wtnfwgpzqnfabpwucygbl35wyq 199 8 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 199 9 most most JJS work_wtnfwgpzqnfabpwucygbl35wyq 199 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 199 11 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 199 12 antibodies antibody NNS work_wtnfwgpzqnfabpwucygbl35wyq 199 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 200 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 200 2 provide provide VBP work_wtnfwgpzqnfabpwucygbl35wyq 200 3 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 200 4 detailed detailed JJ work_wtnfwgpzqnfabpwucygbl35wyq 200 5 discussion discussion NN work_wtnfwgpzqnfabpwucygbl35wyq 200 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 200 7 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 200 8 experiments experiment NNS work_wtnfwgpzqnfabpwucygbl35wyq 200 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 200 10 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 200 11 supplement supplement NN work_wtnfwgpzqnfabpwucygbl35wyq 200 12 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 200 13 given give VBN work_wtnfwgpzqnfabpwucygbl35wyq 200 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 200 15 implications implication NNS work_wtnfwgpzqnfabpwucygbl35wyq 200 16 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 200 17 future future JJ work_wtnfwgpzqnfabpwucygbl35wyq 200 18 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 200 19 involving involve VBG work_wtnfwgpzqnfabpwucygbl35wyq 200 20 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 200 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 201 1 Modelling model VBG work_wtnfwgpzqnfabpwucygbl35wyq 201 2 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 201 3 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 201 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 201 5 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 6 truncation truncation NN work_wtnfwgpzqnfabpwucygbl35wyq 201 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 201 8 vivo vivo NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 9 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 201 10 investigate investigate VB work_wtnfwgpzqnfabpwucygbl35wyq 201 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 201 12 relevance relevance NN work_wtnfwgpzqnfabpwucygbl35wyq 201 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 201 14 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 15 disruption disruption NN work_wtnfwgpzqnfabpwucygbl35wyq 201 16 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 201 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 201 18 hall- hall- NN work_wtnfwgpzqnfabpwucygbl35wyq 201 19 mark mark NN work_wtnfwgpzqnfabpwucygbl35wyq 201 20 features feature NNS work_wtnfwgpzqnfabpwucygbl35wyq 201 21 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 201 22 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 23 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 201 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 201 25 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 201 26 targeted target VBD work_wtnfwgpzqnfabpwucygbl35wyq 201 27 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 201 28 sole sole JJ work_wtnfwgpzqnfabpwucygbl35wyq 201 29 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 30 ortholog ortholog NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 31 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 201 32 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 33 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 201 34 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 201 35 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 201 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 202 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 202 2 recent recent JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 3 report report NN work_wtnfwgpzqnfabpwucygbl35wyq 202 4 showed show VBD work_wtnfwgpzqnfabpwucygbl35wyq 202 5 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 202 6 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 202 7 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 202 8 expressed express VBN work_wtnfwgpzqnfabpwucygbl35wyq 202 9 near near RB work_wtnfwgpzqnfabpwucygbl35wyq 202 10 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 202 11 ubiquitously ubiquitously RB work_wtnfwgpzqnfabpwucygbl35wyq 202 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 202 13 developing develop VBG work_wtnfwgpzqnfabpwucygbl35wyq 202 14 zebra- zebra- JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 15 fish fish NN work_wtnfwgpzqnfabpwucygbl35wyq 202 16 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 202 18 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 202 19 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 202 20 either either DT work_wtnfwgpzqnfabpwucygbl35wyq 202 21 transient transient JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 22 suppression suppression NN work_wtnfwgpzqnfabpwucygbl35wyq 202 23 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 202 24 stable stable JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 25 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 202 26 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 202 27 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 202 28 leads lead VBZ work_wtnfwgpzqnfabpwucygbl35wyq 202 29 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 202 30 gross gross JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 31 developmental developmental JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 32 defects defect NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 33 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 202 34 due due IN work_wtnfwgpzqnfabpwucygbl35wyq 202 35 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 202 36 altered alter VBN work_wtnfwgpzqnfabpwucygbl35wyq 202 37 Akt Akt NNP work_wtnfwgpzqnfabpwucygbl35wyq 202 38 stability.6 stability.6 NNP work_wtnfwgpzqnfabpwucygbl35wyq 202 39 Notably notably RB work_wtnfwgpzqnfabpwucygbl35wyq 202 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 202 41 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 202 42 homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 43 mutants mutant NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 44 display display VBP work_wtnfwgpzqnfabpwucygbl35wyq 202 45 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 202 46 cycle cycle NN work_wtnfwgpzqnfabpwucygbl35wyq 202 47 dysregulation dysregulation NN work_wtnfwgpzqnfabpwucygbl35wyq 202 48 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 202 49 massive massive JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 50 apoptosis apoptosis NN work_wtnfwgpzqnfabpwucygbl35wyq 202 51 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 202 52 anterior anterior JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 53 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 54 subsequent subsequent JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 55 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 202 56 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 202 57 depletion depletion NN work_wtnfwgpzqnfabpwucygbl35wyq 202 58 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 202 59 maternal maternal JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 60 transcript.6 transcript.6 NN work_wtnfwgpzqnfabpwucygbl35wyq 202 61 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 202 62 complement complement VB work_wtnfwgpzqnfabpwucygbl35wyq 202 63 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 202 64 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 65 , , , work_wtnfwgpzqnfabpwucygbl35wyq 202 66 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 202 67 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 202 68 test test VB work_wtnfwgpzqnfabpwucygbl35wyq 202 69 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 202 70 patho- patho- JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 71 genic genic JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 72 potential potential NN work_wtnfwgpzqnfabpwucygbl35wyq 202 73 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 202 74 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 202 75 . . . work_wtnfwgpzqnfabpwucygbl35wyq 202 76 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 202 77 , , , work_wtnfwgpzqnfabpwucygbl35wyq 202 78 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 202 79 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 202 80 obtained obtain VBD work_wtnfwgpzqnfabpwucygbl35wyq 202 81 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 202 82 MOs mo NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 83 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 202 84 target target VBP work_wtnfwgpzqnfabpwucygbl35wyq 202 85 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 202 86 splice splice NN work_wtnfwgpzqnfabpwucygbl35wyq 202 87 donor donor NN work_wtnfwgpzqnfabpwucygbl35wyq 202 88 sites site NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 89 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 202 90 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 202 91 exons exon NNS work_wtnfwgpzqnfabpwucygbl35wyq 202 92 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 202 93 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 202 94 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 202 95 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 202 96 sb1 sb1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 202 97 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 202 98 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 99 , , , work_wtnfwgpzqnfabpwucygbl35wyq 202 100 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 202 101 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 202 102 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 103 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 202 104 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 202 105 S4.1A S4.1A NNP work_wtnfwgpzqnfabpwucygbl35wyq 202 106 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 202 107 . . . work_wtnfwgpzqnfabpwucygbl35wyq 203 1 First first RB work_wtnfwgpzqnfabpwucygbl35wyq 203 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 203 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 203 4 confirmed confirm VBD work_wtnfwgpzqnfabpwucygbl35wyq 203 5 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 203 6 both both DT work_wtnfwgpzqnfabpwucygbl35wyq 203 7 MOs mo NNS work_wtnfwgpzqnfabpwucygbl35wyq 203 8 reduce reduce VBP work_wtnfwgpzqnfabpwucygbl35wyq 203 9 endogenous endogenous JJ work_wtnfwgpzqnfabpwucygbl35wyq 203 10 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 203 11 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 203 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 204 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 204 2 injected inject VBD work_wtnfwgpzqnfabpwucygbl35wyq 204 3 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 204 4 ng ng NN work_wtnfwgpzqnfabpwucygbl35wyq 204 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 204 6 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 204 7 MO mo NN work_wtnfwgpzqnfabpwucygbl35wyq 204 8 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 204 9 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 204 10 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 204 11 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 204 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 204 13 one one CD work_wtnfwgpzqnfabpwucygbl35wyq 204 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 204 15 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 204 16 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 204 17 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 204 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 204 19 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 204 20 stage stage NN work_wtnfwgpzqnfabpwucygbl35wyq 204 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 204 22 harvested harvest VBD work_wtnfwgpzqnfabpwucygbl35wyq 204 23 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 204 24 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 204 25 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 204 26 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 204 27 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 204 28 evaluated evaluated JJ work_wtnfwgpzqnfabpwucygbl35wyq 204 29 cep55l cep55l NNS work_wtnfwgpzqnfabpwucygbl35wyq 204 30 splicing splice VBG work_wtnfwgpzqnfabpwucygbl35wyq 204 31 near near IN work_wtnfwgpzqnfabpwucygbl35wyq 204 32 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 204 33 target target NN work_wtnfwgpzqnfabpwucygbl35wyq 204 34 sites site NNS work_wtnfwgpzqnfabpwucygbl35wyq 204 35 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 204 36 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 204 37 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 204 38 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 204 39 . . . work_wtnfwgpzqnfabpwucygbl35wyq 205 1 For for IN work_wtnfwgpzqnfabpwucygbl35wyq 205 2 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 205 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 205 4 sb1 sb1 NN work_wtnfwgpzqnfabpwucygbl35wyq 205 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 205 6 sb2 sb2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 205 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 205 8 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 205 9 observed observe VBD work_wtnfwgpzqnfabpwucygbl35wyq 205 10 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 205 11 reduction reduction NN work_wtnfwgpzqnfabpwucygbl35wyq 205 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 205 13 detectable detectable JJ work_wtnfwgpzqnfabpwucygbl35wyq 205 14 quantities quantity NNS work_wtnfwgpzqnfabpwucygbl35wyq 205 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 205 16 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 205 17 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 205 18 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 205 19 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 205 20 morphants morphant NNS work_wtnfwgpzqnfabpwucygbl35wyq 205 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 205 22 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 205 23 due due IN work_wtnfwgpzqnfabpwucygbl35wyq 205 24 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 205 25 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 205 26 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 205 27 induced induce VBN work_wtnfwgpzqnfabpwucygbl35wyq 205 28 aberrant aberrant JJ work_wtnfwgpzqnfabpwucygbl35wyq 205 29 splicing splicing NN work_wtnfwgpzqnfabpwucygbl35wyq 205 30 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 205 31 introduced introduce VBD work_wtnfwgpzqnfabpwucygbl35wyq 205 32 premature premature JJ work_wtnfwgpzqnfabpwucygbl35wyq 205 33 termination termination NN work_wtnfwgpzqnfabpwucygbl35wyq 205 34 codons codon NNS work_wtnfwgpzqnfabpwucygbl35wyq 205 35 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 205 36 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 205 37 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 205 38 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 205 39 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 205 40 S4.1B S4.1B NNP work_wtnfwgpzqnfabpwucygbl35wyq 205 41 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 205 42 . . . work_wtnfwgpzqnfabpwucygbl35wyq 206 1 Figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 206 2 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 206 3 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 206 4 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 206 5 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 206 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 206 7 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 206 8 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 206 9 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 206 10 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 206 11 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 206 12 patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 206 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 207 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 207 2 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 207 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 207 4 Schematic Schematic NNP work_wtnfwgpzqnfabpwucygbl35wyq 207 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 207 6 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 207 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 208 1 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 208 2 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 208 3 transcript transcript NNP work_wtnfwgpzqnfabpwucygbl35wyq 208 4 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 5 NM_018131.4 NM_018131.4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 208 6 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 208 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 208 9 encoded encoded JJ work_wtnfwgpzqnfabpwucygbl35wyq 208 10 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 208 11 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 12 NP_060601.3 NP_060601.3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 208 13 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 208 15 indicating indicate VBG work_wtnfwgpzqnfabpwucygbl35wyq 208 16 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 208 17 polymorphisms polymorphism NNS work_wtnfwgpzqnfabpwucygbl35wyq 208 18 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 19 black black JJ work_wtnfwgpzqnfabpwucygbl35wyq 208 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 208 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 208 23 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 208 24 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 208 25 detected detect VBN work_wtnfwgpzqnfabpwucygbl35wyq 208 26 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 208 27 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 208 28 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 208 29 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 30 red red NNP work_wtnfwgpzqnfabpwucygbl35wyq 208 31 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 208 32 . . . work_wtnfwgpzqnfabpwucygbl35wyq 209 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 209 2 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 209 3 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 209 4 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 209 5 amplified amplify VBN work_wtnfwgpzqnfabpwucygbl35wyq 209 6 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 209 7 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 209 8 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 209 9 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 209 10 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 209 11 indicated indicate VBN work_wtnfwgpzqnfabpwucygbl35wyq 209 12 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 209 13 fragments fragment NNS work_wtnfwgpzqnfabpwucygbl35wyq 209 14 I -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 209 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 209 16 II II NNP work_wtnfwgpzqnfabpwucygbl35wyq 209 17 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 209 18 III III NNP work_wtnfwgpzqnfabpwucygbl35wyq 209 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 209 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 210 1 Polymorphisms Polymorphisms NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 2 rs3740370 rs3740370 NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 3 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 210 4 rs2293277 rs2293277 NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 5 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 210 6 common common JJ work_wtnfwgpzqnfabpwucygbl35wyq 210 7 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 210 8 allele allele NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 9 frequencies frequency NNS work_wtnfwgpzqnfabpwucygbl35wyq 210 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 210 11 0.23 0.23 CD work_wtnfwgpzqnfabpwucygbl35wyq 210 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 210 13 0.70 0.70 CD work_wtnfwgpzqnfabpwucygbl35wyq 210 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 210 15 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 210 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 210 17 based base VBN work_wtnfwgpzqnfabpwucygbl35wyq 210 18 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 210 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 210 20 ExAC ExAC NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 21 Browser Browser NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 210 23 January January NNP work_wtnfwgpzqnfabpwucygbl35wyq 210 24 2016 2016 CD work_wtnfwgpzqnfabpwucygbl35wyq 210 25 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 210 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 211 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 211 2 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 211 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 211 4 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 211 5 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 211 6 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 211 7 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 211 8 lower low JJR work_wtnfwgpzqnfabpwucygbl35wyq 211 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 211 10 patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 211 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 211 12 derived derive VBN work_wtnfwgpzqnfabpwucygbl35wyq 211 13 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 211 14 compared compare VBN work_wtnfwgpzqnfabpwucygbl35wyq 211 15 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 211 16 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 211 17 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 211 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 212 1 Shown Shown NNP work_wtnfwgpzqnfabpwucygbl35wyq 212 2 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 212 3 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 212 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 212 5 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 212 6 fragments fragment NNS work_wtnfwgpzqnfabpwucygbl35wyq 212 7 involving involve VBG work_wtnfwgpzqnfabpwucygbl35wyq 212 8 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 9 I i NN work_wtnfwgpzqnfabpwucygbl35wyq 212 10 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 11 exon exon VBZ work_wtnfwgpzqnfabpwucygbl35wyq 212 12 7–9 7–9 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 14 390 390 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 15 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 212 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 212 18 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 19 II II NNP work_wtnfwgpzqnfabpwucygbl35wyq 212 20 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 21 exon exon VBZ work_wtnfwgpzqnfabpwucygbl35wyq 212 22 7–9 7–9 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 23 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 24 262 262 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 25 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 212 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 212 28 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 29 III iii NN work_wtnfwgpzqnfabpwucygbl35wyq 212 30 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 31 exon exon VBZ work_wtnfwgpzqnfabpwucygbl35wyq 212 32 2–3 2–3 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 33 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 34 287 287 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 35 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 212 36 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 37 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 212 38 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 39 IV IV NNP work_wtnfwgpzqnfabpwucygbl35wyq 212 40 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 41 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 212 42 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 43 GAPDH GAPDH NNP work_wtnfwgpzqnfabpwucygbl35wyq 212 44 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 45 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 212 46 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 47 288 288 CD work_wtnfwgpzqnfabpwucygbl35wyq 212 48 bp bp NN work_wtnfwgpzqnfabpwucygbl35wyq 212 49 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 212 50 . . . work_wtnfwgpzqnfabpwucygbl35wyq 213 1 cDNA cDNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 213 2 input input NN work_wtnfwgpzqnfabpwucygbl35wyq 213 3 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 213 4 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 213 5 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 213 6 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 213 7 twofold twofold JJ work_wtnfwgpzqnfabpwucygbl35wyq 213 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 213 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 213 10 patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 213 11 compared compare VBN work_wtnfwgpzqnfabpwucygbl35wyq 213 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 213 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 213 14 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 213 15 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 213 16 equalise equalise VB work_wtnfwgpzqnfabpwucygbl35wyq 213 17 GAPDH GAPDH NNP work_wtnfwgpzqnfabpwucygbl35wyq 213 18 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 213 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 214 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 214 2 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 214 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 214 4 Sanger Sanger NNP work_wtnfwgpzqnfabpwucygbl35wyq 214 5 sequences sequence NNS work_wtnfwgpzqnfabpwucygbl35wyq 214 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 214 7 fragment fragment NN work_wtnfwgpzqnfabpwucygbl35wyq 214 8 I -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 214 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 214 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 214 11 patient patient NN work_wtnfwgpzqnfabpwucygbl35wyq 214 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 214 13 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 214 14 healthy healthy JJ work_wtnfwgpzqnfabpwucygbl35wyq 214 15 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 214 16 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 214 17 position position NN work_wtnfwgpzqnfabpwucygbl35wyq 214 18 c.1264 c.1264 NNP work_wtnfwgpzqnfabpwucygbl35wyq 214 19 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 214 20 c.1284 c.1284 NNP work_wtnfwgpzqnfabpwucygbl35wyq 214 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 215 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 215 2 asterisk asterisk NN work_wtnfwgpzqnfabpwucygbl35wyq 215 3 indicates indicate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 215 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 215 5 position position NN work_wtnfwgpzqnfabpwucygbl35wyq 215 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 215 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 215 8 stop stop NN work_wtnfwgpzqnfabpwucygbl35wyq 215 9 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 215 10 c.1274C c.1274C -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 215 11 > > FW work_wtnfwgpzqnfabpwucygbl35wyq 215 12 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 215 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 215 14 resulting result VBG work_wtnfwgpzqnfabpwucygbl35wyq 215 15 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 215 16 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 215 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 215 18 S425X. s425x. XX work_wtnfwgpzqnfabpwucygbl35wyq 216 1 There there EX work_wtnfwgpzqnfabpwucygbl35wyq 216 2 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 216 3 no no DT work_wtnfwgpzqnfabpwucygbl35wyq 216 4 indications indication NNS work_wtnfwgpzqnfabpwucygbl35wyq 216 5 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 216 6 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 216 7 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 216 8 induces induce VBZ work_wtnfwgpzqnfabpwucygbl35wyq 216 9 aberrant aberrant JJ work_wtnfwgpzqnfabpwucygbl35wyq 216 10 splicing splicing NN work_wtnfwgpzqnfabpwucygbl35wyq 216 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 217 1 496 496 CD work_wtnfwgpzqnfabpwucygbl35wyq 217 2 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 217 3   _SP work_wtnfwgpzqnfabpwucygbl35wyq 217 4 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 217 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 217 6 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 217 7   _SP work_wtnfwgpzqnfabpwucygbl35wyq 217 8 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 217 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 218 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 218 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 218 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 218 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 218 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 219 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 219 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 219 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 219 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 219 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 219 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 219 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 219 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 219 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 219 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 219 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 219 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 219 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 219 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 219 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 219 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 219 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 219 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 219 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 219 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 219 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 219 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 219 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 219 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 219 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 219 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 219 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 219 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 219 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 220 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 220 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 220 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 9 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 12 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 13 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 14 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 15 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 16 Although although IN work_wtnfwgpzqnfabpwucygbl35wyq 220 17 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 18 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 220 19 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 20 display display VBP work_wtnfwgpzqnfabpwucygbl35wyq 220 21 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 220 22 constellation constellation NN work_wtnfwgpzqnfabpwucygbl35wyq 220 23 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 220 24 gross gross JJ work_wtnfwgpzqnfabpwucygbl35wyq 220 25 anatomical anatomical JJ work_wtnfwgpzqnfabpwucygbl35wyq 220 26 abnormalities,6 abnormalities,6 NN work_wtnfwgpzqnfabpwucygbl35wyq 220 27 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 220 28 characterised characterise VBD work_wtnfwgpzqnfabpwucygbl35wyq 220 29 further further RB work_wtnfwgpzqnfabpwucygbl35wyq 220 30 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 220 31 defects defect NNS work_wtnfwgpzqnfabpwucygbl35wyq 220 32 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 220 33 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 220 34 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 220 35 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 220 36 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 220 37 types type NNS work_wtnfwgpzqnfabpwucygbl35wyq 220 38 relevant relevant JJ work_wtnfwgpzqnfabpwucygbl35wyq 220 39 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 220 40 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 220 41 syn- syn- JJ work_wtnfwgpzqnfabpwucygbl35wyq 220 42 drome drome NN work_wtnfwgpzqnfabpwucygbl35wyq 220 43 . . . work_wtnfwgpzqnfabpwucygbl35wyq 221 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 221 2 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 221 3 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 221 4 previously previously RB work_wtnfwgpzqnfabpwucygbl35wyq 221 5 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 221 6 automated automate VBN work_wtnfwgpzqnfabpwucygbl35wyq 221 7 fluorescent fluorescent NN work_wtnfwgpzqnfabpwucygbl35wyq 221 8 imaging imaging NN work_wtnfwgpzqnfabpwucygbl35wyq 221 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 221 10 live live JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 11 -1.4col1a1 -1.4col1a1 : work_wtnfwgpzqnfabpwucygbl35wyq 221 12 : : : work_wtnfwgpzqnfabpwucygbl35wyq 221 13 egfp egfp NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 14 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 15 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 16 can can MD work_wtnfwgpzqnfabpwucygbl35wyq 221 17 demarcate demarcate VB work_wtnfwgpzqnfabpwucygbl35wyq 221 18 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 221 19 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 221 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 221 21 pharyngeal pharyngeal NN work_wtnfwgpzqnfabpwucygbl35wyq 221 22 skeleton skeleton NN work_wtnfwgpzqnfabpwucygbl35wyq 221 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 221 24 while while IN work_wtnfwgpzqnfabpwucygbl35wyq 221 25 enabling enable VBG work_wtnfwgpzqnfabpwucygbl35wyq 221 26 quantitative quantitative JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 27 assessment assessment NN work_wtnfwgpzqnfabpwucygbl35wyq 221 28 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 221 29 altered alter VBN work_wtnfwgpzqnfabpwucygbl35wyq 221 30 craniofacial craniofacial NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 31 morphology morphology NN work_wtnfwgpzqnfabpwucygbl35wyq 221 32 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 221 33 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 34 models model NNS work_wtnfwgpzqnfabpwucygbl35wyq 221 35 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 221 36 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 37 disease.15 disease.15 NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 38 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 221 39 injected inject VBD work_wtnfwgpzqnfabpwucygbl35wyq 221 40 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 41 embryo embryo NN work_wtnfwgpzqnfabpwucygbl35wyq 221 42 batches batch NNS work_wtnfwgpzqnfabpwucygbl35wyq 221 43 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 221 44 increasing increase VBG work_wtnfwgpzqnfabpwucygbl35wyq 221 45 doses dose NNS work_wtnfwgpzqnfabpwucygbl35wyq 221 46 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 221 47 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 48 sb1 sb1 NN work_wtnfwgpzqnfabpwucygbl35wyq 221 49 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 221 50 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 51 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 221 52 acquired acquire VBN work_wtnfwgpzqnfabpwucygbl35wyq 221 53 ventral ventral JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 54 images image NNS work_wtnfwgpzqnfabpwucygbl35wyq 221 55 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 221 56 GFP GFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 57 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 221 58 positive positive JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 59 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 221 60 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 221 61 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 221 62 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 221 63 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 221 64 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 221 65 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 66 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 221 67 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 221 68 S4.1C S4.1C NNP work_wtnfwgpzqnfabpwucygbl35wyq 221 69 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 221 70 . . . work_wtnfwgpzqnfabpwucygbl35wyq 222 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 222 2 observed observe VBD work_wtnfwgpzqnfabpwucygbl35wyq 222 3 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 222 4 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 222 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 222 6 dose dose RB work_wtnfwgpzqnfabpwucygbl35wyq 222 7 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 222 8 dependent dependent JJ work_wtnfwgpzqnfabpwucygbl35wyq 222 9 increase increase NN work_wtnfwgpzqnfabpwucygbl35wyq 222 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 222 11 cartilage cartilage NN work_wtnfwgpzqnfabpwucygbl35wyq 222 12 disorganisation disorganisation NN work_wtnfwgpzqnfabpwucygbl35wyq 222 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 222 14 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 222 15 Figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 222 16 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 222 17 Transient transient JJ work_wtnfwgpzqnfabpwucygbl35wyq 222 18 suppression suppression NN work_wtnfwgpzqnfabpwucygbl35wyq 222 19 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 222 20 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 222 21 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 222 22 Cas9 Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 222 23 mediated mediate VBN work_wtnfwgpzqnfabpwucygbl35wyq 222 24 genome genome NN work_wtnfwgpzqnfabpwucygbl35wyq 222 25 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 222 26 editing editing NN work_wtnfwgpzqnfabpwucygbl35wyq 222 27 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 222 28 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 222 29 results result NNS work_wtnfwgpzqnfabpwucygbl35wyq 222 30 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 222 31 craniofacial craniofacial JJ work_wtnfwgpzqnfabpwucygbl35wyq 222 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 222 33 neurological neurological JJ work_wtnfwgpzqnfabpwucygbl35wyq 222 34 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 222 35 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 222 36 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 222 37 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 222 38 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 222 39 . . . work_wtnfwgpzqnfabpwucygbl35wyq 223 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 223 2 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 223 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 223 4 Representative representative NN work_wtnfwgpzqnfabpwucygbl35wyq 223 5 live live VB work_wtnfwgpzqnfabpwucygbl35wyq 223 6 ventral ventral JJ work_wtnfwgpzqnfabpwucygbl35wyq 223 7 views view NNS work_wtnfwgpzqnfabpwucygbl35wyq 223 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 223 9 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 223 10 dpf dpf NNP work_wtnfwgpzqnfabpwucygbl35wyq 223 11 -1.4col1a1 -1.4col1a1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 223 12 : : : work_wtnfwgpzqnfabpwucygbl35wyq 223 13 eGFP eGFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 223 14 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 223 15 showing show VBG work_wtnfwgpzqnfabpwucygbl35wyq 223 16 craniofacial craniofacial JJ work_wtnfwgpzqnfabpwucygbl35wyq 223 17 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 223 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 224 1 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 224 2 F0 f0 NN work_wtnfwgpzqnfabpwucygbl35wyq 224 3 mutants mutant NNS work_wtnfwgpzqnfabpwucygbl35wyq 224 4 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 224 5 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 224 6 morphant morphant JJ work_wtnfwgpzqnfabpwucygbl35wyq 224 7 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 224 8 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 224 9 significantly significantly RB work_wtnfwgpzqnfabpwucygbl35wyq 224 10 broader broad JJR work_wtnfwgpzqnfabpwucygbl35wyq 224 11 ceratohyal ceratohyal NN work_wtnfwgpzqnfabpwucygbl35wyq 224 12 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 224 13 CH CH NNP work_wtnfwgpzqnfabpwucygbl35wyq 224 14 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 224 15 angles angle NNS work_wtnfwgpzqnfabpwucygbl35wyq 224 16 compared compare VBN work_wtnfwgpzqnfabpwucygbl35wyq 224 17 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 224 18 controls control NNS work_wtnfwgpzqnfabpwucygbl35wyq 224 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 225 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 225 2 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 225 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 225 4 Plot Plot NNP work_wtnfwgpzqnfabpwucygbl35wyq 225 5 indicates indicate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 225 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 225 7 measurement measurement NN work_wtnfwgpzqnfabpwucygbl35wyq 225 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 225 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 225 10 ceratohyal ceratohyal NNP work_wtnfwgpzqnfabpwucygbl35wyq 225 11 angle angle NN work_wtnfwgpzqnfabpwucygbl35wyq 225 12 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 225 13 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 225 14 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 225 15 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 225 16 panel panel NN work_wtnfwgpzqnfabpwucygbl35wyq 225 17 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 225 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 225 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 226 1 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 226 2 injected inject VBD work_wtnfwgpzqnfabpwucygbl35wyq 226 3 alone alone RB work_wtnfwgpzqnfabpwucygbl35wyq 226 4 shows show NNS work_wtnfwgpzqnfabpwucygbl35wyq 226 5 no no DT work_wtnfwgpzqnfabpwucygbl35wyq 226 6 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 226 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 227 1 Larvae Larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 227 2 injected inject VBN work_wtnfwgpzqnfabpwucygbl35wyq 227 3 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 227 4 sb2 sb2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 227 5 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 227 6 sgRNA+Cas9 sgRNA+Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 227 7 display display NN work_wtnfwgpzqnfabpwucygbl35wyq 227 8 significantly significantly RB work_wtnfwgpzqnfabpwucygbl35wyq 227 9 increased increase VBD work_wtnfwgpzqnfabpwucygbl35wyq 227 10 ceratohyal ceratohyal NN work_wtnfwgpzqnfabpwucygbl35wyq 227 11 angle angle NN work_wtnfwgpzqnfabpwucygbl35wyq 227 12 compared compare VBN work_wtnfwgpzqnfabpwucygbl35wyq 227 13 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 227 14 controls control NNS work_wtnfwgpzqnfabpwucygbl35wyq 227 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 228 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 228 2 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 228 3 can can MD work_wtnfwgpzqnfabpwucygbl35wyq 228 4 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 228 5 rescued rescue VBN work_wtnfwgpzqnfabpwucygbl35wyq 228 6 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 228 7 coinjection coinjection NN work_wtnfwgpzqnfabpwucygbl35wyq 228 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 228 9 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 228 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 228 11 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 228 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 228 13 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 228 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 228 15 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 228 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 228 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 228 18 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 228 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 228 20 H378-RNA H378-RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 228 21 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 228 22 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 228 23 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 228 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 228 25 L378-RNA L378-RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 228 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 229 1 sb2+S425X sb2+S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 229 2 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 229 3 does do VBZ work_wtnfwgpzqnfabpwucygbl35wyq 229 4 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 229 5 rescue rescue VB work_wtnfwgpzqnfabpwucygbl35wyq 229 6 significantly significantly RB work_wtnfwgpzqnfabpwucygbl35wyq 229 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 230 1 n=23–62 n=23–62 NNP work_wtnfwgpzqnfabpwucygbl35wyq 230 2 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 230 3 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 230 4 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 230 5 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 230 6 repeated repeat VBN work_wtnfwgpzqnfabpwucygbl35wyq 230 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 231 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 231 2 C c NN work_wtnfwgpzqnfabpwucygbl35wyq 231 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 231 4 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 231 5 dpf dpf NNP work_wtnfwgpzqnfabpwucygbl35wyq 231 6 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 231 7 stained stain VBN work_wtnfwgpzqnfabpwucygbl35wyq 231 8 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 231 9 acetylated acetylate VBN work_wtnfwgpzqnfabpwucygbl35wyq 231 10 tubulin tubulin NNP work_wtnfwgpzqnfabpwucygbl35wyq 231 11 show show NNP work_wtnfwgpzqnfabpwucygbl35wyq 231 12 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 231 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 231 14 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 231 15 regions region NNS work_wtnfwgpzqnfabpwucygbl35wyq 231 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 231 17 including include VBG work_wtnfwgpzqnfabpwucygbl35wyq 231 18 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 231 19 cerebellum cerebellum NN work_wtnfwgpzqnfabpwucygbl35wyq 231 20 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 231 21 optic optic JJ work_wtnfwgpzqnfabpwucygbl35wyq 231 22 tecta tecta NN work_wtnfwgpzqnfabpwucygbl35wyq 231 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 232 1 Box Box NNP work_wtnfwgpzqnfabpwucygbl35wyq 232 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 232 3 zoomed zoomed JJ work_wtnfwgpzqnfabpwucygbl35wyq 232 4 image image NN work_wtnfwgpzqnfabpwucygbl35wyq 232 5 indicate indicate VBP work_wtnfwgpzqnfabpwucygbl35wyq 232 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 232 7 cerebellum cerebellum NN work_wtnfwgpzqnfabpwucygbl35wyq 232 8 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 232 9 asterisks asterisks RB work_wtnfwgpzqnfabpwucygbl35wyq 232 10 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 232 11 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 232 12 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 232 13 indicate indicate VBP work_wtnfwgpzqnfabpwucygbl35wyq 232 14 optic optic JJ work_wtnfwgpzqnfabpwucygbl35wyq 232 15 tecta tecta NN work_wtnfwgpzqnfabpwucygbl35wyq 232 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 233 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 233 2 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 233 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 233 4 Plot plot NN work_wtnfwgpzqnfabpwucygbl35wyq 233 5 indicates indicate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 233 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 233 7 quantification quantification NN work_wtnfwgpzqnfabpwucygbl35wyq 233 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 233 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 233 10 total total JJ work_wtnfwgpzqnfabpwucygbl35wyq 233 11 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 233 12 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 233 13 mm2 mm2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 233 14 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 233 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 233 16 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 233 17 cerebellum cerebellum NN work_wtnfwgpzqnfabpwucygbl35wyq 233 18 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 233 19 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 233 20 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 233 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 233 22 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 233 23 indicated indicate VBN work_wtnfwgpzqnfabpwucygbl35wyq 233 24 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 233 25 orange orange NNP work_wtnfwgpzqnfabpwucygbl35wyq 233 26 outline outline NN work_wtnfwgpzqnfabpwucygbl35wyq 233 27 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 233 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 233 29 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 233 30 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 233 31 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 233 32 insets inset NNS work_wtnfwgpzqnfabpwucygbl35wyq 233 33 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 233 34 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 233 35 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 233 36 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 233 37 . . . work_wtnfwgpzqnfabpwucygbl35wyq 234 1 n=31–81 n=31–81 NNP work_wtnfwgpzqnfabpwucygbl35wyq 234 2 embryos embryos NNPS work_wtnfwgpzqnfabpwucygbl35wyq 234 3 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 234 4 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 234 5 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 234 6 repeated repeat VBN work_wtnfwgpzqnfabpwucygbl35wyq 234 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 235 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 235 2 E e NN work_wtnfwgpzqnfabpwucygbl35wyq 235 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 235 4 Larvae Larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 235 5 fixed fix VBN work_wtnfwgpzqnfabpwucygbl35wyq 235 6 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 235 7 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 235 8 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 235 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 235 10 stained stain VBN work_wtnfwgpzqnfabpwucygbl35wyq 235 11 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 235 12 Na+/K+ATPase Na+/K+ATPase NNP work_wtnfwgpzqnfabpwucygbl35wyq 235 13 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 235 14 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 235 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 235 16 lateral lateral JJ work_wtnfwgpzqnfabpwucygbl35wyq 235 17 view view NN work_wtnfwgpzqnfabpwucygbl35wyq 235 18 ; ; , work_wtnfwgpzqnfabpwucygbl35wyq 235 19 zoomed zoomed JJ work_wtnfwgpzqnfabpwucygbl35wyq 235 20 image image NN work_wtnfwgpzqnfabpwucygbl35wyq 235 21 represents represent VBZ work_wtnfwgpzqnfabpwucygbl35wyq 235 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 235 23 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 235 24 convoluted convoluted JJ work_wtnfwgpzqnfabpwucygbl35wyq 235 25 tubule tubule NN work_wtnfwgpzqnfabpwucygbl35wyq 235 26 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 235 27 outline outline NN work_wtnfwgpzqnfabpwucygbl35wyq 235 28 indicates indicate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 235 29 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 235 30 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 235 31 quantified quantify VBN work_wtnfwgpzqnfabpwucygbl35wyq 235 32 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 235 33 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 235 34 F f NN work_wtnfwgpzqnfabpwucygbl35wyq 235 35 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 235 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 236 1 Embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 236 2 injected inject VBN work_wtnfwgpzqnfabpwucygbl35wyq 236 3 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 236 4 cep55 cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 236 5 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 236 6 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 236 7 sgRNA sgrna JJ work_wtnfwgpzqnfabpwucygbl35wyq 236 8 + + CC work_wtnfwgpzqnfabpwucygbl35wyq 236 9 Cas9 Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 236 10 display display VB work_wtnfwgpzqnfabpwucygbl35wyq 236 11 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 236 12 tubules tubule NNS work_wtnfwgpzqnfabpwucygbl35wyq 236 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 236 14 decreased decrease VBN work_wtnfwgpzqnfabpwucygbl35wyq 236 15 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 236 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 236 17 mm2 mm2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 236 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 236 19 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 236 20 decreased decrease VBN work_wtnfwgpzqnfabpwucygbl35wyq 236 21 presence presence NN work_wtnfwgpzqnfabpwucygbl35wyq 236 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 236 23 convolutions convolution NNS work_wtnfwgpzqnfabpwucygbl35wyq 236 24 compared compare VBN work_wtnfwgpzqnfabpwucygbl35wyq 236 25 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 236 26 control control NN work_wtnfwgpzqnfabpwucygbl35wyq 236 27 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 236 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 237 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 237 2 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 237 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 237 4 Plot Plot NNP work_wtnfwgpzqnfabpwucygbl35wyq 237 5 indicates indicate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 237 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 237 7 total total JJ work_wtnfwgpzqnfabpwucygbl35wyq 237 8 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 237 9 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 237 10 mm2 mm2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 237 11 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 237 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 237 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 237 14 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 237 15 tubule tubule NN work_wtnfwgpzqnfabpwucygbl35wyq 237 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 237 17 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 237 18 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 237 19 larvae larva NNS work_wtnfwgpzqnfabpwucygbl35wyq 237 20 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 237 21 n=31–61 n=31–61 NNP work_wtnfwgpzqnfabpwucygbl35wyq 237 22 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 237 23 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 237 24 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 237 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 237 26 repeated repeat VBN work_wtnfwgpzqnfabpwucygbl35wyq 237 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 238 1 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 238 3 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 4 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 238 6 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 7 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 8 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 238 10 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 11 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 12 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 13 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 238 14 indicate indicate VBP work_wtnfwgpzqnfabpwucygbl35wyq 238 15 p<0.05 p<0.05 JJ work_wtnfwgpzqnfabpwucygbl35wyq 238 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 238 17 0.01 0.01 CD work_wtnfwgpzqnfabpwucygbl35wyq 238 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 238 19 0.001 0.001 CD work_wtnfwgpzqnfabpwucygbl35wyq 238 20 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 238 21 0.0001 0.0001 CD work_wtnfwgpzqnfabpwucygbl35wyq 238 22 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 238 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 239 1 ns ns IN work_wtnfwgpzqnfabpwucygbl35wyq 239 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 239 3 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 239 4 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 239 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 240 1 497Frosk 497Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 240 2   _SP work_wtnfwgpzqnfabpwucygbl35wyq 240 3 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 240 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 240 5 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 240 6   _SP work_wtnfwgpzqnfabpwucygbl35wyq 240 7 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 240 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 241 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 241 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 241 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 241 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 241 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 242 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 242 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 242 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 242 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 242 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 242 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 242 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 242 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 242 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 242 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 242 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 242 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 242 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 242 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 242 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 242 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 242 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 242 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 242 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 242 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 242 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 242 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 242 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 242 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 242 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 242 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 242 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 242 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 242 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 243 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 243 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 243 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 243 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 12 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 13 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 243 14 quantified quantify VBN work_wtnfwgpzqnfabpwucygbl35wyq 243 15 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 243 16 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 243 17 angle angle NN work_wtnfwgpzqnfabpwucygbl35wyq 243 18 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 243 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 243 20 ceratohyal ceratohyal NN work_wtnfwgpzqnfabpwucygbl35wyq 243 21 cartilage cartilage NN work_wtnfwgpzqnfabpwucygbl35wyq 243 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 244 1 Both both DT work_wtnfwgpzqnfabpwucygbl35wyq 244 2 MOs MOs NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 3 produced produce VBD work_wtnfwgpzqnfabpwucygbl35wyq 244 4 similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 244 5 micrognathia micrognathia NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 6 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 244 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 244 8 could could MD work_wtnfwgpzqnfabpwucygbl35wyq 244 9 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 244 10 rescued rescue VBN work_wtnfwgpzqnfabpwucygbl35wyq 244 11 significantly significantly RB work_wtnfwgpzqnfabpwucygbl35wyq 244 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 244 13 co co NN work_wtnfwgpzqnfabpwucygbl35wyq 244 14 - - NN work_wtnfwgpzqnfabpwucygbl35wyq 244 15 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 244 16 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 244 17 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 18 human human NN work_wtnfwgpzqnfabpwucygbl35wyq 244 19 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 20 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 244 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 244 22 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 244 23 4A 4A NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 244 25 B B NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 26 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 244 27 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 244 28 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 244 29 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 244 30 S4.1D S4.1D NNP work_wtnfwgpzqnfabpwucygbl35wyq 244 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 244 32 E e NN work_wtnfwgpzqnfabpwucygbl35wyq 244 33 ; ; , work_wtnfwgpzqnfabpwucygbl35wyq 244 34 repeated repeat VBN work_wtnfwgpzqnfabpwucygbl35wyq 244 35 , , , work_wtnfwgpzqnfabpwucygbl35wyq 244 36 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 244 37 masked masked JJ work_wtnfwgpzqnfabpwucygbl35wyq 244 38 scoring scoring NN work_wtnfwgpzqnfabpwucygbl35wyq 244 39 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 244 40 . . . work_wtnfwgpzqnfabpwucygbl35wyq 245 1 Next next RB work_wtnfwgpzqnfabpwucygbl35wyq 245 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 245 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 245 4 fixed fix VBD work_wtnfwgpzqnfabpwucygbl35wyq 245 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 245 6 immunostained immunostaine VBD work_wtnfwgpzqnfabpwucygbl35wyq 245 7 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 245 8 MO mo NN work_wtnfwgpzqnfabpwucygbl35wyq 245 9 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 245 10 injected inject VBN work_wtnfwgpzqnfabpwucygbl35wyq 245 11 larvae larvae NNP work_wtnfwgpzqnfabpwucygbl35wyq 245 12 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 245 13 evaluate evaluate VB work_wtnfwgpzqnfabpwucygbl35wyq 245 14 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 245 15 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 245 16 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 245 17 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 245 18 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 245 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 246 1 Demarcation demarcation NN work_wtnfwgpzqnfabpwucygbl35wyq 246 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 246 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 246 4 axon axon JJ work_wtnfwgpzqnfabpwucygbl35wyq 246 5 tracts tract NNS work_wtnfwgpzqnfabpwucygbl35wyq 246 6 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 246 7 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 246 8 anti anti NN work_wtnfwgpzqnfabpwucygbl35wyq 246 9 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 246 10 acetylated acetylated JJ work_wtnfwgpzqnfabpwucygbl35wyq 246 11 α α NNP work_wtnfwgpzqnfabpwucygbl35wyq 246 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 246 13 tubulin tubulin NNP work_wtnfwgpzqnfabpwucygbl35wyq 246 14 antibody16 antibody16 VBD work_wtnfwgpzqnfabpwucygbl35wyq 246 15 41 41 CD work_wtnfwgpzqnfabpwucygbl35wyq 246 16 42 42 CD work_wtnfwgpzqnfabpwucygbl35wyq 246 17 revealed reveal VBD work_wtnfwgpzqnfabpwucygbl35wyq 246 18 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 246 19 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 246 20 reduction reduction NN work_wtnfwgpzqnfabpwucygbl35wyq 246 21 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 246 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 246 23 size size NN work_wtnfwgpzqnfabpwucygbl35wyq 246 24 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 246 25 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 246 26 structures structure NNS work_wtnfwgpzqnfabpwucygbl35wyq 246 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 247 1 Similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 247 2 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 247 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 247 4 cerebellar cerebellar JJ work_wtnfwgpzqnfabpwucygbl35wyq 247 5 hypoplasia hypoplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 247 6 observed observe VBN work_wtnfwgpzqnfabpwucygbl35wyq 247 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 247 8 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 247 9 cases case NNS work_wtnfwgpzqnfabpwucygbl35wyq 247 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 247 11 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 247 12 saw see VBD work_wtnfwgpzqnfabpwucygbl35wyq 247 13 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 247 14 ∼28 ∼28 NNP work_wtnfwgpzqnfabpwucygbl35wyq 247 15 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 247 16 reduction reduction NN work_wtnfwgpzqnfabpwucygbl35wyq 247 17 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 247 18 dorsal dorsal NN work_wtnfwgpzqnfabpwucygbl35wyq 247 19 cerebellar cerebellar JJ work_wtnfwgpzqnfabpwucygbl35wyq 247 20 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 247 21 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 247 22 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 247 23 morphants morphant NNS work_wtnfwgpzqnfabpwucygbl35wyq 247 24 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 247 25 comparison comparison NN work_wtnfwgpzqnfabpwucygbl35wyq 247 26 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 247 27 controls control NNS work_wtnfwgpzqnfabpwucygbl35wyq 247 28 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 247 29 p<0.0001 p<0.0001 NN work_wtnfwgpzqnfabpwucygbl35wyq 247 30 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 247 31 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 247 32 4C 4c NN work_wtnfwgpzqnfabpwucygbl35wyq 247 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 247 34 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 247 35 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 247 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 248 1 To to IN work_wtnfwgpzqnfabpwucygbl35wyq 248 2 deter- deter- VB work_wtnfwgpzqnfabpwucygbl35wyq 248 3 mine mine NN work_wtnfwgpzqnfabpwucygbl35wyq 248 4 whether whether IN work_wtnfwgpzqnfabpwucygbl35wyq 248 5 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 248 6 morphants morphant NNS work_wtnfwgpzqnfabpwucygbl35wyq 248 7 display display VBP work_wtnfwgpzqnfabpwucygbl35wyq 248 8 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 248 9 atrophy atrophy NN work_wtnfwgpzqnfabpwucygbl35wyq 248 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 248 11 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 248 12 marked mark VBD work_wtnfwgpzqnfabpwucygbl35wyq 248 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 248 14 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 248 15 tubules tubule NNS work_wtnfwgpzqnfabpwucygbl35wyq 248 16 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 248 17 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 248 18 dpf dpf NNP work_wtnfwgpzqnfabpwucygbl35wyq 248 19 larval larval NN work_wtnfwgpzqnfabpwucygbl35wyq 248 20 batches batch NNS work_wtnfwgpzqnfabpwucygbl35wyq 248 21 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 248 22 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 248 23 - - NNS work_wtnfwgpzqnfabpwucygbl35wyq 248 24 Na Na NNP work_wtnfwgpzqnfabpwucygbl35wyq 248 25 + + SYM work_wtnfwgpzqnfabpwucygbl35wyq 248 26 /K+ /k+ SYM work_wtnfwgpzqnfabpwucygbl35wyq 248 27 ATPase ATPase NNP work_wtnfwgpzqnfabpwucygbl35wyq 248 28 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 248 29 . . . work_wtnfwgpzqnfabpwucygbl35wyq 249 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 249 2 observed observe VBD work_wtnfwgpzqnfabpwucygbl35wyq 249 3 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 249 4 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 249 5 reduction reduction NN work_wtnfwgpzqnfabpwucygbl35wyq 249 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 249 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 249 8 lateral lateral JJ work_wtnfwgpzqnfabpwucygbl35wyq 249 9 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 249 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 249 11 convolution convolution NN work_wtnfwgpzqnfabpwucygbl35wyq 249 12 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 249 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 249 14 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 249 15 tubule tubule NN work_wtnfwgpzqnfabpwucygbl35wyq 249 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 249 17 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 249 18 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 249 19 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 249 20 injected inject VBN work_wtnfwgpzqnfabpwucygbl35wyq 249 21 batches batch NNS work_wtnfwgpzqnfabpwucygbl35wyq 249 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 249 23 p<0.0001 p<0.0001 NN work_wtnfwgpzqnfabpwucygbl35wyq 249 24 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 249 25 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 249 26 4E 4e NN work_wtnfwgpzqnfabpwucygbl35wyq 249 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 249 28 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 249 29 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 249 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 250 1 Importantly importantly RB work_wtnfwgpzqnfabpwucygbl35wyq 250 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 250 3 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 250 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 250 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 250 6 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 250 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 250 8 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 250 9 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 250 10 could could MD work_wtnfwgpzqnfabpwucygbl35wyq 250 11 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 250 12 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 250 13 rescued rescue VBN work_wtnfwgpzqnfabpwucygbl35wyq 250 14 sig- sig- RB work_wtnfwgpzqnfabpwucygbl35wyq 250 15 nificantly nificantly RB work_wtnfwgpzqnfabpwucygbl35wyq 250 16 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 250 17 co co NN work_wtnfwgpzqnfabpwucygbl35wyq 250 18 - - NN work_wtnfwgpzqnfabpwucygbl35wyq 250 19 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 250 20 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 250 21 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 250 22 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 250 23 capped cap VBN work_wtnfwgpzqnfabpwucygbl35wyq 250 24 human human NN work_wtnfwgpzqnfabpwucygbl35wyq 250 25 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 250 26 mRNA mrna NN work_wtnfwgpzqnfabpwucygbl35wyq 250 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 251 1 Finally finally RB work_wtnfwgpzqnfabpwucygbl35wyq 251 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 251 3 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 251 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 251 5 cellular cellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 251 6 level level NN work_wtnfwgpzqnfabpwucygbl35wyq 251 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 251 8 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 251 9 reproduced reproduce VBD work_wtnfwgpzqnfabpwucygbl35wyq 251 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 251 11 previ- previ- NN work_wtnfwgpzqnfabpwucygbl35wyq 251 12 ously ously RB work_wtnfwgpzqnfabpwucygbl35wyq 251 13 reported report VBN work_wtnfwgpzqnfabpwucygbl35wyq 251 14 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 251 15 apparently apparently RB work_wtnfwgpzqnfabpwucygbl35wyq 251 16 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 251 17 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 251 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 251 19 phase phase NN work_wtnfwgpzqnfabpwucygbl35wyq 251 20 marker marker NN work_wtnfwgpzqnfabpwucygbl35wyq 251 21 staining staining NN work_wtnfwgpzqnfabpwucygbl35wyq 251 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 251 23 phospho phospho NN work_wtnfwgpzqnfabpwucygbl35wyq 251 24 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 251 25 histone histone NNP work_wtnfwgpzqnfabpwucygbl35wyq 251 26 H3 H3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 251 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 251 28 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 251 29 concomitant concomitant JJ work_wtnfwgpzqnfabpwucygbl35wyq 251 30 apoptosis apoptosis NN work_wtnfwgpzqnfabpwucygbl35wyq 251 31 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 251 32 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 251 33 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 251 34 morphants morphant NNS work_wtnfwgpzqnfabpwucygbl35wyq 251 35 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 251 36 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 251 37 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 251 38 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 251 39 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 251 40 S4 S4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 251 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 252 1 2A 2a LS work_wtnfwgpzqnfabpwucygbl35wyq 252 2 – – : work_wtnfwgpzqnfabpwucygbl35wyq 252 3 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 252 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 252 5 ref ref NN work_wtnfwgpzqnfabpwucygbl35wyq 252 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 253 1 6 6 LS work_wtnfwgpzqnfabpwucygbl35wyq 253 2 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 253 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 254 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 254 2 confirm confirm VB work_wtnfwgpzqnfabpwucygbl35wyq 254 3 further further RB work_wtnfwgpzqnfabpwucygbl35wyq 254 4 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 254 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 254 6 observed observe VBN work_wtnfwgpzqnfabpwucygbl35wyq 254 7 anatomical anatomical JJ work_wtnfwgpzqnfabpwucygbl35wyq 254 8 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 254 9 cellular cellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 254 10 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 254 11 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 254 12 specific specific JJ work_wtnfwgpzqnfabpwucygbl35wyq 254 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 254 14 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 254 15 targeted target VBD work_wtnfwgpzqnfabpwucygbl35wyq 254 16 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 254 17 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 254 18 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 254 19 locus locus NN work_wtnfwgpzqnfabpwucygbl35wyq 254 20 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 254 21 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 254 22 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 254 23 Cas9 Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 254 24 genome genome NN work_wtnfwgpzqnfabpwucygbl35wyq 254 25 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 254 26 editing edit VBG work_wtnfwgpzqnfabpwucygbl35wyq 254 27 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 254 28 repeated repeat VBD work_wtnfwgpzqnfabpwucygbl35wyq 254 29 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 254 30 subset subset NN work_wtnfwgpzqnfabpwucygbl35wyq 254 31 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 254 32 phe- phe- RB work_wtnfwgpzqnfabpwucygbl35wyq 254 33 notyping notype VBG work_wtnfwgpzqnfabpwucygbl35wyq 254 34 measures measure NNS work_wtnfwgpzqnfabpwucygbl35wyq 254 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 255 1 Consistent consistent JJ work_wtnfwgpzqnfabpwucygbl35wyq 255 2 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 255 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 255 4 transient transient JJ work_wtnfwgpzqnfabpwucygbl35wyq 255 5 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 255 6 model model NN work_wtnfwgpzqnfabpwucygbl35wyq 255 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 255 8 F0 f0 NN work_wtnfwgpzqnfabpwucygbl35wyq 255 9 mutants mutant NNS work_wtnfwgpzqnfabpwucygbl35wyq 255 10 displayed display VBD work_wtnfwgpzqnfabpwucygbl35wyq 255 11 altered alter VBN work_wtnfwgpzqnfabpwucygbl35wyq 255 12 craniofacial craniofacial JJ work_wtnfwgpzqnfabpwucygbl35wyq 255 13 patterning pattern VBG work_wtnfwgpzqnfabpwucygbl35wyq 255 14 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 255 15 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 255 16 sig- sig- NN work_wtnfwgpzqnfabpwucygbl35wyq 255 17 nificantly nificantly RB work_wtnfwgpzqnfabpwucygbl35wyq 255 18 more more RBR work_wtnfwgpzqnfabpwucygbl35wyq 255 19 obtuse obtuse JJ work_wtnfwgpzqnfabpwucygbl35wyq 255 20 ceratohyal ceratohyal NN work_wtnfwgpzqnfabpwucygbl35wyq 255 21 angle angle NN work_wtnfwgpzqnfabpwucygbl35wyq 255 22 than than IN work_wtnfwgpzqnfabpwucygbl35wyq 255 23 controls control NNS work_wtnfwgpzqnfabpwucygbl35wyq 255 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 255 25 p<0.0001 p<0.0001 NNP work_wtnfwgpzqnfabpwucygbl35wyq 255 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 255 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 255 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 255 29 atrophy atrophy NN work_wtnfwgpzqnfabpwucygbl35wyq 255 30 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 255 31 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 255 32 proximal proximal JJ work_wtnfwgpzqnfabpwucygbl35wyq 255 33 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 255 34 tubules tubule NNS work_wtnfwgpzqnfabpwucygbl35wyq 255 35 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 255 36 p=0.0016 p=0.0016 RB work_wtnfwgpzqnfabpwucygbl35wyq 255 37 vs. vs. IN work_wtnfwgpzqnfabpwucygbl35wyq 255 38 controls control NNS work_wtnfwgpzqnfabpwucygbl35wyq 255 39 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 255 40 . . . work_wtnfwgpzqnfabpwucygbl35wyq 256 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 256 2 next next JJ work_wtnfwgpzqnfabpwucygbl35wyq 256 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 256 4 generation generation NN work_wtnfwgpzqnfabpwucygbl35wyq 256 5 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 256 6 approach approach NN work_wtnfwgpzqnfabpwucygbl35wyq 256 7 estimated estimate VBD work_wtnfwgpzqnfabpwucygbl35wyq 256 8 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 256 9 targeted target VBN work_wtnfwgpzqnfabpwucygbl35wyq 256 10 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 256 11 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 256 12 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 256 13 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 256 14 as as RB work_wtnfwgpzqnfabpwucygbl35wyq 256 15 much much JJ work_wtnfwgpzqnfabpwucygbl35wyq 256 16 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 256 17 76 76 CD work_wtnfwgpzqnfabpwucygbl35wyq 256 18 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 256 19 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 256 20 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 256 21 sequenced sequence VBN work_wtnfwgpzqnfabpwucygbl35wyq 256 22 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 256 23 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 256 24 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 256 25 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 256 26 , , , work_wtnfwgpzqnfabpwucygbl35wyq 256 27 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 256 28 decreased decrease VBD work_wtnfwgpzqnfabpwucygbl35wyq 256 29 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 256 30 17 17 CD work_wtnfwgpzqnfabpwucygbl35wyq 256 31 – – : work_wtnfwgpzqnfabpwucygbl35wyq 256 32 25 25 CD work_wtnfwgpzqnfabpwucygbl35wyq 256 33 % % NN work_wtnfwgpzqnfabpwucygbl35wyq 256 34 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 256 35 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 256 36 dpf dpf NN work_wtnfwgpzqnfabpwucygbl35wyq 256 37 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 256 38 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 256 39 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 256 40 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 256 41 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 256 42 S4.1F S4.1F NNP work_wtnfwgpzqnfabpwucygbl35wyq 256 43 , , , work_wtnfwgpzqnfabpwucygbl35wyq 256 44 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 256 45 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 256 46 . . . work_wtnfwgpzqnfabpwucygbl35wyq 257 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 257 2 most most RBS work_wtnfwgpzqnfabpwucygbl35wyq 257 3 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 257 4 explanation explanation NN work_wtnfwgpzqnfabpwucygbl35wyq 257 5 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 257 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 257 7 reduction reduction NN work_wtnfwgpzqnfabpwucygbl35wyq 257 8 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 257 9 apoptosis apoptosis NN work_wtnfwgpzqnfabpwucygbl35wyq 257 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 257 11 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 257 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 257 13 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 257 14 disruption disruption NN work_wtnfwgpzqnfabpwucygbl35wyq 257 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 257 16 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 257 17 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 257 18 supported support VBN work_wtnfwgpzqnfabpwucygbl35wyq 257 19 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 257 20 TUNEL TUNEL NNP work_wtnfwgpzqnfabpwucygbl35wyq 257 21 assay assay NN work_wtnfwgpzqnfabpwucygbl35wyq 257 22 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 257 23 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 257 24 dpf dpf NNP work_wtnfwgpzqnfabpwucygbl35wyq 257 25 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 257 26 see see VB work_wtnfwgpzqnfabpwucygbl35wyq 257 27 ref ref NNP work_wtnfwgpzqnfabpwucygbl35wyq 257 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 258 1 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 258 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 258 3 online online JJ work_wtnfwgpzqnfabpwucygbl35wyq 258 4 supplementary supplementary JJ work_wtnfwgpzqnfabpwucygbl35wyq 258 5 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 258 6 S4.2C S4.2C NNP work_wtnfwgpzqnfabpwucygbl35wyq 258 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 258 8 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 258 9 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 258 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 259 1 Prompted prompt VBN work_wtnfwgpzqnfabpwucygbl35wyq 259 2 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 259 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 259 4 observations observation NNS work_wtnfwgpzqnfabpwucygbl35wyq 259 5 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 259 6 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 7 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 8 harbouring harbouring NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 9 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 259 11 S425X s425x CD work_wtnfwgpzqnfabpwucygbl35wyq 259 12 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 259 13 detectable detectable JJ work_wtnfwgpzqnfabpwucygbl35wyq 259 14 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 259 15 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 16 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 259 17 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 18 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 259 19 patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 259 20 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 259 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 259 22 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 259 23 predicted predict VBN work_wtnfwgpzqnfabpwucygbl35wyq 259 24 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 259 25 produce produce VB work_wtnfwgpzqnfabpwucygbl35wyq 259 26 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 259 27 truncated truncated JJ work_wtnfwgpzqnfabpwucygbl35wyq 259 28 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 259 29 , , , work_wtnfwgpzqnfabpwucygbl35wyq 259 30 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 259 31 carried carry VBD work_wtnfwgpzqnfabpwucygbl35wyq 259 32 out out RP work_wtnfwgpzqnfabpwucygbl35wyq 259 33 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 259 34 vivo vivo NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 35 complementation complementation NNP work_wtnfwgpzqnfabpwucygbl35wyq 259 36 assays assays RB work_wtnfwgpzqnfabpwucygbl35wyq 259 37 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 259 38 determine determine VB work_wtnfwgpzqnfabpwucygbl35wyq 259 39 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 259 40 pathogenicity pathogenicity NN work_wtnfwgpzqnfabpwucygbl35wyq 259 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 260 1 First first RB work_wtnfwgpzqnfabpwucygbl35wyq 260 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 260 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 260 4 confirmed confirm VBD work_wtnfwgpzqnfabpwucygbl35wyq 260 5 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 260 6 assay assay NN work_wtnfwgpzqnfabpwucygbl35wyq 260 7 specificity specificity NN work_wtnfwgpzqnfabpwucygbl35wyq 260 8 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 260 9 comparing compare VBG work_wtnfwgpzqnfabpwucygbl35wyq 260 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 260 11 rescue rescue NN work_wtnfwgpzqnfabpwucygbl35wyq 260 12 efficiency efficiency NN work_wtnfwgpzqnfabpwucygbl35wyq 260 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 260 14 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 260 15 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 260 16 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 260 17 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 260 18 encoding encode VBG work_wtnfwgpzqnfabpwucygbl35wyq 260 19 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 260 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 260 21 H378 H378 NNP work_wtnfwgpzqnfabpwucygbl35wyq 260 22 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 260 23 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 260 24 that that DT work_wtnfwgpzqnfabpwucygbl35wyq 260 25 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 260 26 message message NN work_wtnfwgpzqnfabpwucygbl35wyq 260 27 encoding encode VBG work_wtnfwgpzqnfabpwucygbl35wyq 260 28 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 260 29 common common JJ work_wtnfwgpzqnfabpwucygbl35wyq 260 30 variant variant NN work_wtnfwgpzqnfabpwucygbl35wyq 260 31 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 260 32 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 260 33 same same JJ work_wtnfwgpzqnfabpwucygbl35wyq 260 34 amino amino JJ work_wtnfwgpzqnfabpwucygbl35wyq 260 35 acid acid NN work_wtnfwgpzqnfabpwucygbl35wyq 260 36 position position NN work_wtnfwgpzqnfabpwucygbl35wyq 260 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 260 38 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 260 39 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 260 40 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 260 41 identified identify VBN work_wtnfwgpzqnfabpwucygbl35wyq 260 42 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 260 43 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 260 44 affected affected JJ work_wtnfwgpzqnfabpwucygbl35wyq 260 45 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 260 46 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 260 47 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 260 48 . . . work_wtnfwgpzqnfabpwucygbl35wyq 260 49 L378 l378 NN work_wtnfwgpzqnfabpwucygbl35wyq 260 50 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 260 51 rs2293277 rs2293277 NNP work_wtnfwgpzqnfabpwucygbl35wyq 260 52 , , , work_wtnfwgpzqnfabpwucygbl35wyq 260 53 allele allele NNP work_wtnfwgpzqnfabpwucygbl35wyq 260 54 frequency frequency NNP work_wtnfwgpzqnfabpwucygbl35wyq 260 55 0.70 0.70 CD work_wtnfwgpzqnfabpwucygbl35wyq 260 56 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 260 57 ExAC ExAC NNP work_wtnfwgpzqnfabpwucygbl35wyq 260 58 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 260 59 . . . work_wtnfwgpzqnfabpwucygbl35wyq 261 1 For for IN work_wtnfwgpzqnfabpwucygbl35wyq 261 2 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 261 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 261 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 261 5 craniofacial craniofacial JJ work_wtnfwgpzqnfabpwucygbl35wyq 261 6 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 261 7 ceratohyal ceratohyal NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 8 angle angle NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 9 measurement measurement NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 10 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 261 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 261 12 cerebel- cerebel- NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 13 lar lar NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 14 area area NN work_wtnfwgpzqnfabpwucygbl35wyq 261 15 phenotyping phenotype VBG work_wtnfwgpzqnfabpwucygbl35wyq 261 16 approaches approach NNS work_wtnfwgpzqnfabpwucygbl35wyq 261 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 261 18 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 261 19 observed observe VBD work_wtnfwgpzqnfabpwucygbl35wyq 261 20 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 261 21 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 22 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 261 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 261 24 L378 L378 NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 25 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 261 26 rescued rescue VBD work_wtnfwgpzqnfabpwucygbl35wyq 261 27 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 261 28 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 261 29 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 30 defects defect NNS work_wtnfwgpzqnfabpwucygbl35wyq 261 31 significantly significantly RB work_wtnfwgpzqnfabpwucygbl35wyq 261 32 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 261 33 p<0.0001 p<0.0001 NNP work_wtnfwgpzqnfabpwucygbl35wyq 261 34 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 261 35 both both DT work_wtnfwgpzqnfabpwucygbl35wyq 261 36 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 261 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 261 38 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 261 39 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 261 40 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 261 41 5B 5b NN work_wtnfwgpzqnfabpwucygbl35wyq 261 42 , , , work_wtnfwgpzqnfabpwucygbl35wyq 261 43 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 261 44 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 261 45 . . . work_wtnfwgpzqnfabpwucygbl35wyq 262 1 However however RB work_wtnfwgpzqnfabpwucygbl35wyq 262 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 262 3 co co NN work_wtnfwgpzqnfabpwucygbl35wyq 262 4 - - NN work_wtnfwgpzqnfabpwucygbl35wyq 262 5 injection injection NN work_wtnfwgpzqnfabpwucygbl35wyq 262 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 262 7 sb2 sb2 JJ work_wtnfwgpzqnfabpwucygbl35wyq 262 8 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 9 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 262 10 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 11 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 12 harbour- harbour- NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 13 ing ing NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 262 15 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 262 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 262 17 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 18 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 262 19 produced produce VBD work_wtnfwgpzqnfabpwucygbl35wyq 262 20 jaw jaw NN work_wtnfwgpzqnfabpwucygbl35wyq 262 21 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 262 22 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 262 23 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 262 24 sig- sig- RB work_wtnfwgpzqnfabpwucygbl35wyq 262 25 nificantly nificantly RB work_wtnfwgpzqnfabpwucygbl35wyq 262 26 worse bad JJR work_wtnfwgpzqnfabpwucygbl35wyq 262 27 than than IN work_wtnfwgpzqnfabpwucygbl35wyq 262 28 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 29 mRNA mrna NN work_wtnfwgpzqnfabpwucygbl35wyq 262 30 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 262 31 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 262 32 . . . work_wtnfwgpzqnfabpwucygbl35wyq 262 33 H378 H378 NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 34 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 262 35 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 262 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 262 37 L378 l378 NN work_wtnfwgpzqnfabpwucygbl35wyq 262 38 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 262 39 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 262 40 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 262 41 significantly significantly RB work_wtnfwgpzqnfabpwucygbl35wyq 262 42 different different JJ work_wtnfwgpzqnfabpwucygbl35wyq 262 43 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 262 44 MO MO NNP work_wtnfwgpzqnfabpwucygbl35wyq 262 45 alone alone RB work_wtnfwgpzqnfabpwucygbl35wyq 262 46 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 262 47 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 262 48 4B 4b NN work_wtnfwgpzqnfabpwucygbl35wyq 262 49 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 262 50 . . . work_wtnfwgpzqnfabpwucygbl35wyq 263 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 263 2 trend trend NN work_wtnfwgpzqnfabpwucygbl35wyq 263 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 263 4 similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 263 5 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 263 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 263 7 cerebellar cerebellar JJ work_wtnfwgpzqnfabpwucygbl35wyq 263 8 assay assay NN work_wtnfwgpzqnfabpwucygbl35wyq 263 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 263 10 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 263 11 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 263 12 only only RB work_wtnfwgpzqnfabpwucygbl35wyq 263 13 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 263 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 263 15 p. p. NN work_wtnfwgpzqnfabpwucygbl35wyq 263 16 L378 l378 NN work_wtnfwgpzqnfabpwucygbl35wyq 263 17 encoding encode VBG work_wtnfwgpzqnfabpwucygbl35wyq 263 18 mRNA mRNA . work_wtnfwgpzqnfabpwucygbl35wyq 263 19 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 263 20 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 263 21 4D 4D NNP work_wtnfwgpzqnfabpwucygbl35wyq 263 22 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 263 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 264 1 Taken take VBN work_wtnfwgpzqnfabpwucygbl35wyq 264 2 together together RB work_wtnfwgpzqnfabpwucygbl35wyq 264 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 264 4 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 264 5 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 264 6 transient transient NN work_wtnfwgpzqnfabpwucygbl35wyq 264 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 264 8 F0 F0 NNP work_wtnfwgpzqnfabpwucygbl35wyq 264 9 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 264 10 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 264 11 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 264 12 relevance relevance NN work_wtnfwgpzqnfabpwucygbl35wyq 264 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 264 14 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 264 15 disruption disruption NN work_wtnfwgpzqnfabpwucygbl35wyq 264 16 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 264 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 264 18 primary primary JJ work_wtnfwgpzqnfabpwucygbl35wyq 264 19 clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 264 20 features feature NNS work_wtnfwgpzqnfabpwucygbl35wyq 264 21 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 264 22 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 264 23 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 264 24 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 264 25 indi- indi- NN work_wtnfwgpzqnfabpwucygbl35wyq 264 26 cate cate NN work_wtnfwgpzqnfabpwucygbl35wyq 264 27 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 264 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 264 29 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 264 30 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 264 31 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 264 32 functional functional JJ work_wtnfwgpzqnfabpwucygbl35wyq 264 33 null null NN work_wtnfwgpzqnfabpwucygbl35wyq 264 34 variant variant NN work_wtnfwgpzqnfabpwucygbl35wyq 264 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 265 1 Subcellular subcellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 265 2 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 265 3 Previous previous JJ work_wtnfwgpzqnfabpwucygbl35wyq 265 4 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 265 5 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 265 6 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 265 7 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 265 8 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 265 9 localises localise VBZ work_wtnfwgpzqnfabpwucygbl35wyq 265 10 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 265 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 12 centri- centri- NN work_wtnfwgpzqnfabpwucygbl35wyq 265 13 ole ole NNP work_wtnfwgpzqnfabpwucygbl35wyq 265 14 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 265 15 interphase interphase NN work_wtnfwgpzqnfabpwucygbl35wyq 265 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 265 17 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 265 18 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 19 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 265 20 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 265 21 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 22 intracellular intracellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 265 23 bridge bridge NN work_wtnfwgpzqnfabpwucygbl35wyq 265 24 between between IN work_wtnfwgpzqnfabpwucygbl35wyq 265 25 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 265 26 daughter daughter NN work_wtnfwgpzqnfabpwucygbl35wyq 265 27 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 265 28 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 265 29 cytokinesis.43 cytokinesis.43 NNP work_wtnfwgpzqnfabpwucygbl35wyq 265 30 Abnormal Abnormal NNP work_wtnfwgpzqnfabpwucygbl35wyq 265 31 phosphorylation phosphorylation NN work_wtnfwgpzqnfabpwucygbl35wyq 265 32 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 265 33 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 34 C c NN work_wtnfwgpzqnfabpwucygbl35wyq 265 35 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 265 36 terminus terminus NN work_wtnfwgpzqnfabpwucygbl35wyq 265 37 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 265 38 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 39 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 265 40 pre- pre- NN work_wtnfwgpzqnfabpwucygbl35wyq 265 41 vents vent VBZ work_wtnfwgpzqnfabpwucygbl35wyq 265 42 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 43 association association NN work_wtnfwgpzqnfabpwucygbl35wyq 265 44 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 265 45 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 46 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 265 47 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 265 48 causes cause VBZ work_wtnfwgpzqnfabpwucygbl35wyq 265 49 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 265 50 failure.31 failure.31 NNP work_wtnfwgpzqnfabpwucygbl35wyq 265 51 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 52 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 265 53 identified identify VBN work_wtnfwgpzqnfabpwucygbl35wyq 265 54 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 265 55 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 265 56 patients patient NNS work_wtnfwgpzqnfabpwucygbl35wyq 265 57 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 265 58 c.1274C c.1274c XX work_wtnfwgpzqnfabpwucygbl35wyq 265 59 > > FW work_wtnfwgpzqnfabpwucygbl35wyq 265 60 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 265 61 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 265 62 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 265 63 . . . work_wtnfwgpzqnfabpwucygbl35wyq 265 64 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 265 65 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 265 66 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 265 67 predicted predict VBN work_wtnfwgpzqnfabpwucygbl35wyq 265 68 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 265 69 truncate truncate VB work_wtnfwgpzqnfabpwucygbl35wyq 265 70 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 265 71 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 265 72 , , , work_wtnfwgpzqnfabpwucygbl35wyq 265 73 causing cause VBG work_wtnfwgpzqnfabpwucygbl35wyq 265 74 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 265 75 loss loss NN work_wtnfwgpzqnfabpwucygbl35wyq 265 76 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 265 77 all all DT work_wtnfwgpzqnfabpwucygbl35wyq 265 78 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 265 79 key key JJ work_wtnfwgpzqnfabpwucygbl35wyq 265 80 phosphorylated phosphorylate VBN work_wtnfwgpzqnfabpwucygbl35wyq 265 81 serines serine NNS work_wtnfwgpzqnfabpwucygbl35wyq 265 82 . . . work_wtnfwgpzqnfabpwucygbl35wyq 266 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 266 2 hypothesised hypothesise VBD work_wtnfwgpzqnfabpwucygbl35wyq 266 3 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 266 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 266 5 patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 266 6 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 266 7 would would MD work_wtnfwgpzqnfabpwucygbl35wyq 266 8 lead lead VB work_wtnfwgpzqnfabpwucygbl35wyq 266 9 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 266 10 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 266 11 similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 266 12 mislocalisation mislocalisation NN work_wtnfwgpzqnfabpwucygbl35wyq 266 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 266 14 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 266 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 267 1 To to TO work_wtnfwgpzqnfabpwucygbl35wyq 267 2 test test VB work_wtnfwgpzqnfabpwucygbl35wyq 267 3 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 267 4 idea idea NN work_wtnfwgpzqnfabpwucygbl35wyq 267 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 267 6 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 267 7 transfected transfecte VBD work_wtnfwgpzqnfabpwucygbl35wyq 267 8 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 267 9 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 267 10 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 267 11 four four CD work_wtnfwgpzqnfabpwucygbl35wyq 267 12 different different JJ work_wtnfwgpzqnfabpwucygbl35wyq 267 13 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 267 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 267 15 length length NN work_wtnfwgpzqnfabpwucygbl35wyq 267 16 cDNA cdna NN work_wtnfwgpzqnfabpwucygbl35wyq 267 17 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 267 18 constructs construct NNS work_wtnfwgpzqnfabpwucygbl35wyq 267 19 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 267 20 contain contain VBP work_wtnfwgpzqnfabpwucygbl35wyq 267 21 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 267 22 mRFP mrfp NN work_wtnfwgpzqnfabpwucygbl35wyq 267 23 tag tag NN work_wtnfwgpzqnfabpwucygbl35wyq 267 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 268 1 These these DT work_wtnfwgpzqnfabpwucygbl35wyq 268 2 constructs construct NNS work_wtnfwgpzqnfabpwucygbl35wyq 268 3 encode encode VBP work_wtnfwgpzqnfabpwucygbl35wyq 268 4 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 268 5 mRFP mrfp NN work_wtnfwgpzqnfabpwucygbl35wyq 268 6 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 268 7 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 268 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 268 9 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 268 10 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 268 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 268 12 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 268 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 268 14 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 268 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 268 16 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 268 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 268 18 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 268 19 mRFP mrfp NN work_wtnfwgpzqnfabpwucygbl35wyq 268 20 - - : work_wtnfwgpzqnfabpwucygbl35wyq 268 21 CEP55 cep55 FW work_wtnfwgpzqnfabpwucygbl35wyq 268 22 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 268 23 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 268 24 common common JJ work_wtnfwgpzqnfabpwucygbl35wyq 268 25 polymorphism polymorphism NN work_wtnfwgpzqnfabpwucygbl35wyq 268 26 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 268 27 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 268 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 268 29 H57Q h57q NN work_wtnfwgpzqnfabpwucygbl35wyq 268 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 268 31 minor minor JJ work_wtnfwgpzqnfabpwucygbl35wyq 268 32 allele allele NN work_wtnfwgpzqnfabpwucygbl35wyq 268 33 frequency frequency NN work_wtnfwgpzqnfabpwucygbl35wyq 268 34 0.23 0.23 CD work_wtnfwgpzqnfabpwucygbl35wyq 268 35 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 268 36 ExAC ExAC NNP work_wtnfwgpzqnfabpwucygbl35wyq 268 37 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 268 38 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 268 39 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 268 40 . . . work_wtnfwgpzqnfabpwucygbl35wyq 268 41 H378L h378l ADD work_wtnfwgpzqnfabpwucygbl35wyq 268 42 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 268 43 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 268 44 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 268 45 5A 5a NN work_wtnfwgpzqnfabpwucygbl35wyq 268 46 , , , work_wtnfwgpzqnfabpwucygbl35wyq 268 47 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 268 48 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 268 49 . . . work_wtnfwgpzqnfabpwucygbl35wyq 269 1 At at IN work_wtnfwgpzqnfabpwucygbl35wyq 269 2 24 24 CD work_wtnfwgpzqnfabpwucygbl35wyq 269 3 hours hour NNS work_wtnfwgpzqnfabpwucygbl35wyq 269 4 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 269 5 48 48 CD work_wtnfwgpzqnfabpwucygbl35wyq 269 6 hours hour NNS work_wtnfwgpzqnfabpwucygbl35wyq 269 7 post post NN work_wtnfwgpzqnfabpwucygbl35wyq 269 8 trans- trans- JJ work_wtnfwgpzqnfabpwucygbl35wyq 269 9 fection fection NN work_wtnfwgpzqnfabpwucygbl35wyq 269 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 269 11 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 269 12 examined examine VBD work_wtnfwgpzqnfabpwucygbl35wyq 269 13 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 269 14 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 269 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 270 1 As as IN work_wtnfwgpzqnfabpwucygbl35wyq 270 2 expected expect VBN work_wtnfwgpzqnfabpwucygbl35wyq 270 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 270 4 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 270 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 270 6 polymorphism polymorphism NN work_wtnfwgpzqnfabpwucygbl35wyq 270 7 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 270 8 containing contain VBG work_wtnfwgpzqnfabpwucygbl35wyq 270 9 mRFP mrfp NN work_wtnfwgpzqnfabpwucygbl35wyq 270 10 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 270 11 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 270 12 , , , work_wtnfwgpzqnfabpwucygbl35wyq 270 13 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 270 14 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 270 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 270 16 S425X s425x CD work_wtnfwgpzqnfabpwucygbl35wyq 270 17 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 270 18 encoding encode VBG work_wtnfwgpzqnfabpwucygbl35wyq 270 19 mutant mutant NN work_wtnfwgpzqnfabpwucygbl35wyq 270 20 localise localise RB work_wtnfwgpzqnfabpwucygbl35wyq 270 21 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 270 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 270 23 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 270 24 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 270 25 dividing divide VBG work_wtnfwgpzqnfabpwucygbl35wyq 270 26 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 270 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 271 1 On on IN work_wtnfwgpzqnfabpwucygbl35wyq 271 2 western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 3 blot blot NN work_wtnfwgpzqnfabpwucygbl35wyq 271 4 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 271 5 anti anti JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 6 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 7 CEP55 cep55 JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 8 antibody antibody NN work_wtnfwgpzqnfabpwucygbl35wyq 271 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 271 10 either either CC work_wtnfwgpzqnfabpwucygbl35wyq 271 11 WT WT NNP work_wtnfwgpzqnfabpwucygbl35wyq 271 12 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 271 13 polymorphism polymorphism NN work_wtnfwgpzqnfabpwucygbl35wyq 271 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 271 15 containing contain VBG work_wtnfwgpzqnfabpwucygbl35wyq 271 16 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 271 17 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 271 18 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 271 19 migrate migrate NN work_wtnfwgpzqnfabpwucygbl35wyq 271 20 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 271 21 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 271 22 expected expect VBN work_wtnfwgpzqnfabpwucygbl35wyq 271 23 size size NN work_wtnfwgpzqnfabpwucygbl35wyq 271 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 271 25 81 81 CD work_wtnfwgpzqnfabpwucygbl35wyq 271 26 kDa kDa NNS work_wtnfwgpzqnfabpwucygbl35wyq 271 27 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 271 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 271 29 while while IN work_wtnfwgpzqnfabpwucygbl35wyq 271 30 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 31 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 271 32 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 271 33 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 271 34 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 271 35 77 77 CD work_wtnfwgpzqnfabpwucygbl35wyq 271 36 kDa kDa NNS work_wtnfwgpzqnfabpwucygbl35wyq 271 37 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 271 38 figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 271 39 5C 5c NN work_wtnfwgpzqnfabpwucygbl35wyq 271 40 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 271 41 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 271 42 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 271 43 observations observation NNS work_wtnfwgpzqnfabpwucygbl35wyq 271 44 support support VBP work_wtnfwgpzqnfabpwucygbl35wyq 271 45 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 271 46 imaging imaging JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 47 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 271 48 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 271 49 together together RB work_wtnfwgpzqnfabpwucygbl35wyq 271 50 suggest suggest VBP work_wtnfwgpzqnfabpwucygbl35wyq 271 51 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 271 52 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 271 53 last last JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 54 40 40 CD work_wtnfwgpzqnfabpwucygbl35wyq 271 55 amino amino JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 56 acids acid NNS work_wtnfwgpzqnfabpwucygbl35wyq 271 57 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 271 58 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 271 59 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 271 60 essential essential JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 61 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 271 62 targeting target VBG work_wtnfwgpzqnfabpwucygbl35wyq 271 63 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 271 64 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 271 65 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 271 66 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 271 67 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 271 68 divi- divi- JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 69 ding ding JJ work_wtnfwgpzqnfabpwucygbl35wyq 271 70 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 271 71 . . . work_wtnfwgpzqnfabpwucygbl35wyq 272 1 DISCUSSION DISCUSSION NNP work_wtnfwgpzqnfabpwucygbl35wyq 272 2 Here here RB work_wtnfwgpzqnfabpwucygbl35wyq 272 3 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 272 4 report report VBP work_wtnfwgpzqnfabpwucygbl35wyq 272 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 272 6 identification identification NN work_wtnfwgpzqnfabpwucygbl35wyq 272 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 272 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 272 9 homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 272 10 truncating truncating JJ work_wtnfwgpzqnfabpwucygbl35wyq 272 11 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 272 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 272 13 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 272 14 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 272 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 272 16 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 272 17 cause cause NN work_wtnfwgpzqnfabpwucygbl35wyq 272 18 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 272 19 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 272 20 new new JJ work_wtnfwgpzqnfabpwucygbl35wyq 272 21 perinatal perinatal JJ work_wtnfwgpzqnfabpwucygbl35wyq 272 22 lethal lethal JJ work_wtnfwgpzqnfabpwucygbl35wyq 272 23 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 272 24 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 272 25 term term NN work_wtnfwgpzqnfabpwucygbl35wyq 272 26 MARCH MARCH NNS work_wtnfwgpzqnfabpwucygbl35wyq 272 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 273 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 273 2 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 273 3 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 273 4 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 273 5 led lead VBD work_wtnfwgpzqnfabpwucygbl35wyq 273 6 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 273 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 273 8 identification identification NN work_wtnfwgpzqnfabpwucygbl35wyq 273 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 273 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 273 11 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 273 12 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 273 13 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 273 14 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 273 15 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 273 16 single single JJ work_wtnfwgpzqnfabpwucygbl35wyq 273 17 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 273 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 273 19 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 273 20 therefore therefore RB work_wtnfwgpzqnfabpwucygbl35wyq 273 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 273 22 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 273 23 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 273 24 difficult difficult JJ work_wtnfwgpzqnfabpwucygbl35wyq 273 25 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 273 26 rule rule VB work_wtnfwgpzqnfabpwucygbl35wyq 273 27 out out RP work_wtnfwgpzqnfabpwucygbl35wyq 273 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 273 29 possibility possibility NN work_wtnfwgpzqnfabpwucygbl35wyq 273 30 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 273 31 multiple multiple JJ work_wtnfwgpzqnfabpwucygbl35wyq 273 32 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 273 33 effects effect NNS work_wtnfwgpzqnfabpwucygbl35wyq 273 34 leading lead VBG work_wtnfwgpzqnfabpwucygbl35wyq 273 35 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 273 36 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 273 37 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 273 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 274 1 However however RB work_wtnfwgpzqnfabpwucygbl35wyq 274 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 274 3 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 274 4 func- func- JJ work_wtnfwgpzqnfabpwucygbl35wyq 274 5 tional tional JJ work_wtnfwgpzqnfabpwucygbl35wyq 274 6 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 274 7 strongly strongly RB work_wtnfwgpzqnfabpwucygbl35wyq 274 8 support support VBP work_wtnfwgpzqnfabpwucygbl35wyq 274 9 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 274 10 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 274 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 274 12 sole sole JJ work_wtnfwgpzqnfabpwucygbl35wyq 274 13 contributor contributor NN work_wtnfwgpzqnfabpwucygbl35wyq 274 14 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 274 15 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 274 16 complex complex JJ work_wtnfwgpzqnfabpwucygbl35wyq 274 17 condition condition NN work_wtnfwgpzqnfabpwucygbl35wyq 274 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 275 1 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 275 2 encodes encodes NNP work_wtnfwgpzqnfabpwucygbl35wyq 275 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 275 4 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 275 5 464 464 CD work_wtnfwgpzqnfabpwucygbl35wyq 275 6 amino amino NN work_wtnfwgpzqnfabpwucygbl35wyq 275 7 acid acid NN work_wtnfwgpzqnfabpwucygbl35wyq 275 8 peptide peptide NN work_wtnfwgpzqnfabpwucygbl35wyq 275 9 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 275 10 contains contain VBZ work_wtnfwgpzqnfabpwucygbl35wyq 275 11 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 275 12 central central JJ work_wtnfwgpzqnfabpwucygbl35wyq 275 13 coiled coil VBN work_wtnfwgpzqnfabpwucygbl35wyq 275 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 275 15 coil coil NN work_wtnfwgpzqnfabpwucygbl35wyq 275 16 domains.31 domains.31 NNP work_wtnfwgpzqnfabpwucygbl35wyq 275 17 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 275 18 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 275 19 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 275 20 essential essential JJ work_wtnfwgpzqnfabpwucygbl35wyq 275 21 regulator regulator NN work_wtnfwgpzqnfabpwucygbl35wyq 275 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 275 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 275 24 final final JJ work_wtnfwgpzqnfabpwucygbl35wyq 275 25 stages stage NNS work_wtnfwgpzqnfabpwucygbl35wyq 275 26 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 275 27 mitosis mitosis NN work_wtnfwgpzqnfabpwucygbl35wyq 275 28 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 275 29 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 275 30 cultured cultured JJ work_wtnfwgpzqnfabpwucygbl35wyq 275 31 fibroblasts fibroblast NNS work_wtnfwgpzqnfabpwucygbl35wyq 275 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 275 33 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 275 34 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 275 35 localises localise VBZ work_wtnfwgpzqnfabpwucygbl35wyq 275 36 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 275 37 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 275 38 centrosome centrosome NN work_wtnfwgpzqnfabpwucygbl35wyq 275 39 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 275 40 pericentriolar pericentriolar JJ work_wtnfwgpzqnfabpwucygbl35wyq 275 41 matrix matrix NN work_wtnfwgpzqnfabpwucygbl35wyq 275 42 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 275 43 most most JJS work_wtnfwgpzqnfabpwucygbl35wyq 275 44 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 275 45 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 275 46 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 275 47 cycle cycle NN work_wtnfwgpzqnfabpwucygbl35wyq 275 48 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 275 49 diffuses diffuse NNS work_wtnfwgpzqnfabpwucygbl35wyq 275 50 throughout throughout IN work_wtnfwgpzqnfabpwucygbl35wyq 275 51 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 275 52 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 275 53 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 275 54 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 275 55 onset onset NN work_wtnfwgpzqnfabpwucygbl35wyq 275 56 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 275 57 mitosis mitosis NNP work_wtnfwgpzqnfabpwucygbl35wyq 275 58 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 275 59 prophase prophase NN work_wtnfwgpzqnfabpwucygbl35wyq 275 60 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 275 61 . . . work_wtnfwgpzqnfabpwucygbl35wyq 276 1 Later later RB work_wtnfwgpzqnfabpwucygbl35wyq 276 2 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 276 3 mitosis mitosis NN work_wtnfwgpzqnfabpwucygbl35wyq 276 4 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 276 5 anaphase anaphase NNP work_wtnfwgpzqnfabpwucygbl35wyq 276 6 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 276 7 telo- telo- NNP work_wtnfwgpzqnfabpwucygbl35wyq 276 8 phase phase NNP work_wtnfwgpzqnfabpwucygbl35wyq 276 9 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 276 10 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 276 11 aggregates aggregate NNS work_wtnfwgpzqnfabpwucygbl35wyq 276 12 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 276 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 276 14 midzone midzone NN work_wtnfwgpzqnfabpwucygbl35wyq 276 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 276 16 where where WRB work_wtnfwgpzqnfabpwucygbl35wyq 276 17 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 276 18 separation separation NN work_wtnfwgpzqnfabpwucygbl35wyq 276 19 will will MD work_wtnfwgpzqnfabpwucygbl35wyq 276 20 eventually eventually RB work_wtnfwgpzqnfabpwucygbl35wyq 276 21 take take VB work_wtnfwgpzqnfabpwucygbl35wyq 276 22 place place NN work_wtnfwgpzqnfabpwucygbl35wyq 276 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 277 1 During during IN work_wtnfwgpzqnfabpwucygbl35wyq 277 2 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 277 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 4 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 277 5 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 277 6 concentrated concentrate VBN work_wtnfwgpzqnfabpwucygbl35wyq 277 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 277 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 9 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 277 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 12 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 277 13 complex complex JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 14 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 15 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 277 16 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 17 cytoplasmic cytoplasmic JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 18 bridge bridge NN work_wtnfwgpzqnfabpwucygbl35wyq 277 19 between between IN work_wtnfwgpzqnfabpwucygbl35wyq 277 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 21 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 277 22 daughter daughter NN work_wtnfwgpzqnfabpwucygbl35wyq 277 23 cells.43 cells.43 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 24 There there RB work_wtnfwgpzqnfabpwucygbl35wyq 277 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 26 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 277 27 recruits recruit VBZ work_wtnfwgpzqnfabpwucygbl35wyq 277 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 29 Endosome Endosome NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 30 Sorting sort VBG work_wtnfwgpzqnfabpwucygbl35wyq 277 31 Complex Complex NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 32 Required require VBN work_wtnfwgpzqnfabpwucygbl35wyq 277 33 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 277 34 Transport Transport NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 35 machinery machinery NN work_wtnfwgpzqnfabpwucygbl35wyq 277 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 37 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 277 38 other other JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 39 components component NNS work_wtnfwgpzqnfabpwucygbl35wyq 277 40 involved involve VBN work_wtnfwgpzqnfabpwucygbl35wyq 277 41 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 277 42 membrane membrane NN work_wtnfwgpzqnfabpwucygbl35wyq 277 43 fission fission NN work_wtnfwgpzqnfabpwucygbl35wyq 277 44 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 45 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 277 46 promote promote VB work_wtnfwgpzqnfabpwucygbl35wyq 277 47 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 48 formation formation NN work_wtnfwgpzqnfabpwucygbl35wyq 277 49 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 277 50 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 51 cleavage cleavage NN work_wtnfwgpzqnfabpwucygbl35wyq 277 52 furrow furrow NN work_wtnfwgpzqnfabpwucygbl35wyq 277 53 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 277 54 eventually eventually RB work_wtnfwgpzqnfabpwucygbl35wyq 277 55 induce induce VBP work_wtnfwgpzqnfabpwucygbl35wyq 277 56 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 277 57 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 277 58 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 59 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 277 60 cells.44 cells.44 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 61 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 62 disassociation disassociation NN work_wtnfwgpzqnfabpwucygbl35wyq 277 63 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 277 64 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 65 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 277 66 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 67 centriole centriole NN work_wtnfwgpzqnfabpwucygbl35wyq 277 68 appears appear VBZ work_wtnfwgpzqnfabpwucygbl35wyq 277 69 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 277 70 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 277 71 dependent dependent JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 72 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 277 73 phos- phos- JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 74 phorylation phorylation NN work_wtnfwgpzqnfabpwucygbl35wyq 277 75 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 277 76 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 77 two two CD work_wtnfwgpzqnfabpwucygbl35wyq 277 78 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 79 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 277 80 terminal terminal NN work_wtnfwgpzqnfabpwucygbl35wyq 277 81 serines serine NNS work_wtnfwgpzqnfabpwucygbl35wyq 277 82 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 83 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 277 84 . . . work_wtnfwgpzqnfabpwucygbl35wyq 277 85 S425 s425 NN work_wtnfwgpzqnfabpwucygbl35wyq 277 86 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 277 87 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 277 88 . . . work_wtnfwgpzqnfabpwucygbl35wyq 277 89 S428 s428 CD work_wtnfwgpzqnfabpwucygbl35wyq 277 90 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 91 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 277 92 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 277 93 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 277 94 kinases kinase NNS work_wtnfwgpzqnfabpwucygbl35wyq 277 95 Erk2 Erk2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 96 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 277 97 Cdk1.31 Cdk1.31 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 98 Subsequently subsequently RB work_wtnfwgpzqnfabpwucygbl35wyq 277 99 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 100 myotu- myotu- JJ work_wtnfwgpzqnfabpwucygbl35wyq 277 101 bularin bularin NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 102 proteins proteins NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 103 connect connect VBP work_wtnfwgpzqnfabpwucygbl35wyq 277 104 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 105 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 277 106 another another DT work_wtnfwgpzqnfabpwucygbl35wyq 277 107 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 277 108 kinase kinase NN work_wtnfwgpzqnfabpwucygbl35wyq 277 109 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 110 PLK1 PLK1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 111 , , , work_wtnfwgpzqnfabpwucygbl35wyq 277 112 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 277 113 phosphorylates phosphorylate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 277 114 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 277 115 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 277 116 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 277 117 . . . work_wtnfwgpzqnfabpwucygbl35wyq 277 118 S436 s436 NN work_wtnfwgpzqnfabpwucygbl35wyq 277 119 . . . work_wtnfwgpzqnfabpwucygbl35wyq 278 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 278 2 stabilises stabilise VBZ work_wtnfwgpzqnfabpwucygbl35wyq 278 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 278 4 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 278 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 278 6 leads lead VBZ work_wtnfwgpzqnfabpwucygbl35wyq 278 7 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 278 8 its -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 278 9 orderly orderly JJ work_wtnfwgpzqnfabpwucygbl35wyq 278 10 introduction introduction NN work_wtnfwgpzqnfabpwucygbl35wyq 278 11 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 278 12 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 278 13 midbody.32 midbody.32 NNP work_wtnfwgpzqnfabpwucygbl35wyq 278 14 38 38 CD work_wtnfwgpzqnfabpwucygbl35wyq 278 15 45 45 CD work_wtnfwgpzqnfabpwucygbl35wyq 278 16 46 46 CD work_wtnfwgpzqnfabpwucygbl35wyq 278 17 If if IN work_wtnfwgpzqnfabpwucygbl35wyq 278 18 either either DT work_wtnfwgpzqnfabpwucygbl35wyq 278 19 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 278 20 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 278 21 phosphorylation phosphorylation NN work_wtnfwgpzqnfabpwucygbl35wyq 278 22 events event NNS work_wtnfwgpzqnfabpwucygbl35wyq 278 23 does do VBZ work_wtnfwgpzqnfabpwucygbl35wyq 278 24 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 278 25 occur occur VB work_wtnfwgpzqnfabpwucygbl35wyq 278 26 then then RB work_wtnfwgpzqnfabpwucygbl35wyq 278 27 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 278 28 fails fail VBZ work_wtnfwgpzqnfabpwucygbl35wyq 278 29 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 278 30 mitosis mitosis NN work_wtnfwgpzqnfabpwucygbl35wyq 278 31 taking take VBG work_wtnfwgpzqnfabpwucygbl35wyq 278 32 place place NN work_wtnfwgpzqnfabpwucygbl35wyq 278 33 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 278 34 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 278 35 daughter daughter NN work_wtnfwgpzqnfabpwucygbl35wyq 278 36 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 278 37 being be VBG work_wtnfwgpzqnfabpwucygbl35wyq 278 38 unable unable JJ work_wtnfwgpzqnfabpwucygbl35wyq 278 39 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 278 40 separate separate VB work_wtnfwgpzqnfabpwucygbl35wyq 278 41 , , , work_wtnfwgpzqnfabpwucygbl35wyq 278 42 leading lead VBG work_wtnfwgpzqnfabpwucygbl35wyq 278 43 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 278 44 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 278 45 binucleated binucleate VBN work_wtnfwgpzqnfabpwucygbl35wyq 278 46 cell.31 cell.31 NNP work_wtnfwgpzqnfabpwucygbl35wyq 278 47 32 32 CD work_wtnfwgpzqnfabpwucygbl35wyq 278 48 34 34 CD work_wtnfwgpzqnfabpwucygbl35wyq 278 49 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 278 50 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 278 51 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 278 52 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 278 53 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 278 54 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 278 55 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 278 56 c.1274C c.1274c XX work_wtnfwgpzqnfabpwucygbl35wyq 278 57 > > FW work_wtnfwgpzqnfabpwucygbl35wyq 278 58 A a NN work_wtnfwgpzqnfabpwucygbl35wyq 278 59 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 278 60 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 278 61 . . . work_wtnfwgpzqnfabpwucygbl35wyq 278 62 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 278 63 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 278 64 identified identify VBD work_wtnfwgpzqnfabpwucygbl35wyq 278 65 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 278 66 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 278 67 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 278 68 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 278 69 truncates truncate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 278 70 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 278 71 . . . work_wtnfwgpzqnfabpwucygbl35wyq 279 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 279 2 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 279 3 culture culture NN work_wtnfwgpzqnfabpwucygbl35wyq 279 4 experiments experiment NNS work_wtnfwgpzqnfabpwucygbl35wyq 279 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 279 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 279 7 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 279 8 version version NN work_wtnfwgpzqnfabpwucygbl35wyq 279 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 279 10 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 279 11 does do VBZ work_wtnfwgpzqnfabpwucygbl35wyq 279 12 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 279 13 localise localise VB work_wtnfwgpzqnfabpwucygbl35wyq 279 14 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 279 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 279 16 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 279 17 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 279 18 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 279 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 280 1 Given give VBN work_wtnfwgpzqnfabpwucygbl35wyq 280 2 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 280 3 loss loss NN work_wtnfwgpzqnfabpwucygbl35wyq 280 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 280 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 280 6 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 280 7 phosphorylated phosphorylated JJ work_wtnfwgpzqnfabpwucygbl35wyq 280 8 residues residue NNS work_wtnfwgpzqnfabpwucygbl35wyq 280 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 280 10 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 280 11 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 280 12 suggest suggest VBP work_wtnfwgpzqnfabpwucygbl35wyq 280 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 280 14 presence presence NN work_wtnfwgpzqnfabpwucygbl35wyq 280 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 280 16 multi- multi- JJ work_wtnfwgpzqnfabpwucygbl35wyq 280 17 nucleated nucleate VBN work_wtnfwgpzqnfabpwucygbl35wyq 280 18 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 280 19 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 280 20 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 280 21 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 280 22 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 280 23 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 280 24 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 280 25 consequence consequence NN work_wtnfwgpzqnfabpwucygbl35wyq 280 26 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 280 27 failed fail VBN work_wtnfwgpzqnfabpwucygbl35wyq 280 28 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 280 29 . . . work_wtnfwgpzqnfabpwucygbl35wyq 281 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 281 2 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 281 3 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 281 4 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 281 5 cep55l cep55l NNS work_wtnfwgpzqnfabpwucygbl35wyq 281 6 knockdown knockdown VBN work_wtnfwgpzqnfabpwucygbl35wyq 281 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 281 8 CRISPR/ CRISPR/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 281 9 498 498 CD work_wtnfwgpzqnfabpwucygbl35wyq 281 10 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 281 11   _SP work_wtnfwgpzqnfabpwucygbl35wyq 281 12 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 281 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 281 14 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 281 15   _SP work_wtnfwgpzqnfabpwucygbl35wyq 281 16 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 281 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 282 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 282 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 282 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 282 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 282 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 283 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 283 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 283 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 283 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 283 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 283 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 283 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 283 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 283 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 283 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 283 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 283 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 283 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 283 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 283 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 283 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 283 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 283 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 283 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 283 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 283 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 283 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 283 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 283 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 283 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 283 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 283 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 283 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 283 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 284 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 284 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 284 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 9 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 12 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 13 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 14 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 UH work_wtnfwgpzqnfabpwucygbl35wyq 284 15 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NN work_wtnfwgpzqnfabpwucygbl35wyq 284 16 http://dx.doi.org/10.1136/jmedgenet-2016-104296 http://dx.doi.org/10.1136/jmedgenet-2016-104296 NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 17 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 18 Cas9 Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 19 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 284 20 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 284 21 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 22 recapitulates recapitulate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 284 23 most most RBS work_wtnfwgpzqnfabpwucygbl35wyq 284 24 key key JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 25 features feature NNS work_wtnfwgpzqnfabpwucygbl35wyq 284 26 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 284 27 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 284 28 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 284 29 : : : work_wtnfwgpzqnfabpwucygbl35wyq 284 30 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 284 31 reproduce reproduce VBP work_wtnfwgpzqnfabpwucygbl35wyq 284 32 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 284 33 cellular cellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 34 apoptosis apoptosis NN work_wtnfwgpzqnfabpwucygbl35wyq 284 35 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 284 36 neurological neurological JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 37 abnormalities abnormality NNS work_wtnfwgpzqnfabpwucygbl35wyq 284 38 reported report VBD work_wtnfwgpzqnfabpwucygbl35wyq 284 39 previously previously RB work_wtnfwgpzqnfabpwucygbl35wyq 284 40 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 284 41 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 42 F2 F2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 43 mutants mutants NNPS work_wtnfwgpzqnfabpwucygbl35wyq 284 44 har- har- NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 45 bouring boure VBG work_wtnfwgpzqnfabpwucygbl35wyq 284 46 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 284 47 homozygous homozygous JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 48 c.115C c.115C NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 49 > > XX work_wtnfwgpzqnfabpwucygbl35wyq 284 50 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 51 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 284 52 p p LS work_wtnfwgpzqnfabpwucygbl35wyq 284 53 . . . work_wtnfwgpzqnfabpwucygbl35wyq 284 54 E39X E39X NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 55 mutation;6 mutation;6 UH work_wtnfwgpzqnfabpwucygbl35wyq 284 56 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 284 57 quan- quan- RB work_wtnfwgpzqnfabpwucygbl35wyq 284 58 tify tify VB work_wtnfwgpzqnfabpwucygbl35wyq 284 59 further far RBR work_wtnfwgpzqnfabpwucygbl35wyq 284 60 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 284 61 cerebellar cerebellar JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 62 , , , work_wtnfwgpzqnfabpwucygbl35wyq 284 63 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 64 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 284 65 craniofacial craniofacial JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 66 features feature NNS work_wtnfwgpzqnfabpwucygbl35wyq 284 67 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 284 68 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 284 69 cep55l cep55l NN work_wtnfwgpzqnfabpwucygbl35wyq 284 70 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 71 models model NNS work_wtnfwgpzqnfabpwucygbl35wyq 284 72 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 284 73 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 284 74 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 284 75 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 284 76 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 284 77 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 284 78 can can MD work_wtnfwgpzqnfabpwucygbl35wyq 284 79 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 284 80 rescued rescue VBN work_wtnfwgpzqnfabpwucygbl35wyq 284 81 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 284 82 full full JJ work_wtnfwgpzqnfabpwucygbl35wyq 284 83 length length NN work_wtnfwgpzqnfabpwucygbl35wyq 284 84 , , , work_wtnfwgpzqnfabpwucygbl35wyq 284 85 but but CC work_wtnfwgpzqnfabpwucygbl35wyq 284 86 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 284 87 truncated truncate VBN work_wtnfwgpzqnfabpwucygbl35wyq 284 88 human human NN work_wtnfwgpzqnfabpwucygbl35wyq 284 89 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 284 90 mRNA mrna NN work_wtnfwgpzqnfabpwucygbl35wyq 284 91 . . . work_wtnfwgpzqnfabpwucygbl35wyq 285 1 It -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 285 2 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 285 3 possible possible JJ work_wtnfwgpzqnfabpwucygbl35wyq 285 4 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 285 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 285 6 lack lack NN work_wtnfwgpzqnfabpwucygbl35wyq 285 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 285 8 overt overt JJ work_wtnfwgpzqnfabpwucygbl35wyq 285 9 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 285 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 285 11 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 285 12 morphants morphant NNS work_wtnfwgpzqnfabpwucygbl35wyq 285 13 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 285 14 mutants mutant NNS work_wtnfwgpzqnfabpwucygbl35wyq 285 15 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 285 16 due due JJ work_wtnfwgpzqnfabpwucygbl35wyq 285 17 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 285 18 interspecies interspecie NNS work_wtnfwgpzqnfabpwucygbl35wyq 285 19 differences difference NNS work_wtnfwgpzqnfabpwucygbl35wyq 285 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 285 21 particu- particu- VBD work_wtnfwgpzqnfabpwucygbl35wyq 285 22 larly larly RB work_wtnfwgpzqnfabpwucygbl35wyq 285 23 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 285 24 regard regard NN work_wtnfwgpzqnfabpwucygbl35wyq 285 25 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 285 26 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 285 27 development development NN work_wtnfwgpzqnfabpwucygbl35wyq 285 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 285 29 anatomy anatomy NN work_wtnfwgpzqnfabpwucygbl35wyq 285 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 286 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 286 2 mechanism mechanism NN work_wtnfwgpzqnfabpwucygbl35wyq 286 3 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 286 4 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 286 5 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 286 6 nonsense nonsense NN work_wtnfwgpzqnfabpwucygbl35wyq 286 7 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 286 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 286 9 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 286 10 ultimately ultimately RB work_wtnfwgpzqnfabpwucygbl35wyq 286 11 leads lead VBZ work_wtnfwgpzqnfabpwucygbl35wyq 286 12 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 286 13 such such PDT work_wtnfwgpzqnfabpwucygbl35wyq 286 14 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 286 15 dramatic dramatic JJ work_wtnfwgpzqnfabpwucygbl35wyq 286 16 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 286 17 neurological neurological JJ work_wtnfwgpzqnfabpwucygbl35wyq 286 18 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 286 19 remains remain VBZ work_wtnfwgpzqnfabpwucygbl35wyq 286 20 incompletely incompletely RB work_wtnfwgpzqnfabpwucygbl35wyq 286 21 understood understand VBN work_wtnfwgpzqnfabpwucygbl35wyq 286 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 287 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 287 2 know know VBP work_wtnfwgpzqnfabpwucygbl35wyq 287 3 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 287 4 there there EX work_wtnfwgpzqnfabpwucygbl35wyq 287 5 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 287 6 large large JJ work_wtnfwgpzqnfabpwucygbl35wyq 287 7 numbers number NNS work_wtnfwgpzqnfabpwucygbl35wyq 287 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 287 9 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 287 10 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 287 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 287 12 what what WP work_wtnfwgpzqnfabpwucygbl35wyq 287 13 remains remain VBZ work_wtnfwgpzqnfabpwucygbl35wyq 287 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 287 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 287 16 patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 287 17 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 287 18 tissue tissue NN work_wtnfwgpzqnfabpwucygbl35wyq 287 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 287 20 suggesting suggest VBG work_wtnfwgpzqnfabpwucygbl35wyq 287 21 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 287 22 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 287 23 failure failure NN work_wtnfwgpzqnfabpwucygbl35wyq 287 24 likely likely RB work_wtnfwgpzqnfabpwucygbl35wyq 287 25 plays play VBZ work_wtnfwgpzqnfabpwucygbl35wyq 287 26 some some DT work_wtnfwgpzqnfabpwucygbl35wyq 287 27 part part NN work_wtnfwgpzqnfabpwucygbl35wyq 287 28 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 287 29 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 287 30 creation creation NN work_wtnfwgpzqnfabpwucygbl35wyq 287 31 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 287 32 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 287 33 anomaly anomaly NN work_wtnfwgpzqnfabpwucygbl35wyq 287 34 . . . work_wtnfwgpzqnfabpwucygbl35wyq 288 1 It -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 288 2 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 288 3 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 288 4 clear clear JJ work_wtnfwgpzqnfabpwucygbl35wyq 288 5 how how WRB work_wtnfwgpzqnfabpwucygbl35wyq 288 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 288 7 production production NN work_wtnfwgpzqnfabpwucygbl35wyq 288 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 288 9 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 288 10 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 288 11 along along IN work_wtnfwgpzqnfabpwucygbl35wyq 288 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 288 13 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 288 14 potential potential JJ work_wtnfwgpzqnfabpwucygbl35wyq 288 15 migration migration NN work_wtnfwgpzqnfabpwucygbl35wyq 288 16 abnormality abnormality NN work_wtnfwgpzqnfabpwucygbl35wyq 288 17 would would MD work_wtnfwgpzqnfabpwucygbl35wyq 288 18 induce induce VB work_wtnfwgpzqnfabpwucygbl35wyq 288 19 such such JJ work_wtnfwgpzqnfabpwucygbl35wyq 288 20 wide- wide- NN work_wtnfwgpzqnfabpwucygbl35wyq 288 21 spread spread VBN work_wtnfwgpzqnfabpwucygbl35wyq 288 22 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 288 23 death death NN work_wtnfwgpzqnfabpwucygbl35wyq 288 24 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 288 25 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 288 26 cerebral cerebral JJ work_wtnfwgpzqnfabpwucygbl35wyq 288 27 hemispheres hemisphere NNS work_wtnfwgpzqnfabpwucygbl35wyq 288 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 289 1 One one CD work_wtnfwgpzqnfabpwucygbl35wyq 289 2 potential potential JJ work_wtnfwgpzqnfabpwucygbl35wyq 289 3 mechanism mechanism NN work_wtnfwgpzqnfabpwucygbl35wyq 289 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 289 5 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 289 6 suppressed suppress VBN work_wtnfwgpzqnfabpwucygbl35wyq 289 7 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 289 8 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 289 9 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 289 10 signalling signal VBG work_wtnfwgpzqnfabpwucygbl35wyq 289 11 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 289 12 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 289 13 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 289 14 has have VBZ work_wtnfwgpzqnfabpwucygbl35wyq 289 15 been be VBN work_wtnfwgpzqnfabpwucygbl35wyq 289 16 found find VBN work_wtnfwgpzqnfabpwucygbl35wyq 289 17 previously previously RB work_wtnfwgpzqnfabpwucygbl35wyq 289 18 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 289 19 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 289 20 downregulated downregulate VBN work_wtnfwgpzqnfabpwucygbl35wyq 289 21 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 289 22 zeb- zeb- DT work_wtnfwgpzqnfabpwucygbl35wyq 289 23 rafish rafish NN work_wtnfwgpzqnfabpwucygbl35wyq 289 24 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 289 25 absent absent JJ work_wtnfwgpzqnfabpwucygbl35wyq 289 26 CEP55 cep55 UH work_wtnfwgpzqnfabpwucygbl35wyq 289 27 function.6 function.6 CD work_wtnfwgpzqnfabpwucygbl35wyq 289 28 Previous previous JJ work_wtnfwgpzqnfabpwucygbl35wyq 289 29 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 289 30 has have VBZ work_wtnfwgpzqnfabpwucygbl35wyq 289 31 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 289 32 that that DT work_wtnfwgpzqnfabpwucygbl35wyq 289 33 activation activation NN work_wtnfwgpzqnfabpwucygbl35wyq 289 34 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 289 35 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 289 36 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 289 37 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 289 38 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 289 39 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 289 40 protects protect VBZ work_wtnfwgpzqnfabpwucygbl35wyq 289 41 against against IN work_wtnfwgpzqnfabpwucygbl35wyq 289 42 cere- cere- NNP work_wtnfwgpzqnfabpwucygbl35wyq 289 43 bral bral JJ work_wtnfwgpzqnfabpwucygbl35wyq 289 44 ischaemic ischaemic JJ work_wtnfwgpzqnfabpwucygbl35wyq 289 45 damage damage NN work_wtnfwgpzqnfabpwucygbl35wyq 289 46 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 289 47 animal animal NN work_wtnfwgpzqnfabpwucygbl35wyq 289 48 models model NNS work_wtnfwgpzqnfabpwucygbl35wyq 289 49 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 289 50 protects protect VBZ work_wtnfwgpzqnfabpwucygbl35wyq 289 51 cultured cultured IN work_wtnfwgpzqnfabpwucygbl35wyq 289 52 Figure figure NN work_wtnfwgpzqnfabpwucygbl35wyq 289 53 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 289 54 Subcellular subcellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 289 55 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 289 56 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 289 57 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 289 58 . . . work_wtnfwgpzqnfabpwucygbl35wyq 290 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 290 2 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 290 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 290 4 Confocal confocal JJ work_wtnfwgpzqnfabpwucygbl35wyq 290 5 images image NNS work_wtnfwgpzqnfabpwucygbl35wyq 290 6 show show VBP work_wtnfwgpzqnfabpwucygbl35wyq 290 7 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 290 8 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 290 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 290 10 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 290 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 290 12 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 290 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 290 14 polymorphism polymorphism NN work_wtnfwgpzqnfabpwucygbl35wyq 290 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 290 16 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 290 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 290 18 H57Q h57q NN work_wtnfwgpzqnfabpwucygbl35wyq 290 19 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 290 20 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 290 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 290 22 H378L h378l ADD work_wtnfwgpzqnfabpwucygbl35wyq 290 23 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 290 24 containing contain VBG work_wtnfwgpzqnfabpwucygbl35wyq 290 25 monomeric monomeric JJ work_wtnfwgpzqnfabpwucygbl35wyq 290 26 Red Red NNP work_wtnfwgpzqnfabpwucygbl35wyq 290 27 Fluorescent Fluorescent NNP work_wtnfwgpzqnfabpwucygbl35wyq 290 28 Protein Protein NNP work_wtnfwgpzqnfabpwucygbl35wyq 290 29 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 290 30 mRFP)-CEP55 mrfp)-cep55 CD work_wtnfwgpzqnfabpwucygbl35wyq 290 31 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 290 32 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 290 33 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 290 34 . . . work_wtnfwgpzqnfabpwucygbl35wyq 291 1 Mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 291 2 mRFP mrfp NN work_wtnfwgpzqnfabpwucygbl35wyq 291 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 291 4 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 291 5 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 291 6 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 291 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 291 8 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 291 9 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 291 10 did do VBD work_wtnfwgpzqnfabpwucygbl35wyq 291 11 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 291 12 localise localise VB work_wtnfwgpzqnfabpwucygbl35wyq 291 13 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 291 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 291 15 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 291 16 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 291 17 transfected transfected JJ work_wtnfwgpzqnfabpwucygbl35wyq 291 18 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 291 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 292 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 292 2 representative representative JJ work_wtnfwgpzqnfabpwucygbl35wyq 292 3 image image NN work_wtnfwgpzqnfabpwucygbl35wyq 292 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 292 5 dividing divide VBG work_wtnfwgpzqnfabpwucygbl35wyq 292 6 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 292 7 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 292 8 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 292 9 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 292 10 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 292 11 condition condition NN work_wtnfwgpzqnfabpwucygbl35wyq 292 12 , , , work_wtnfwgpzqnfabpwucygbl35wyq 292 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 292 14 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 292 15 magnification magnification NN work_wtnfwgpzqnfabpwucygbl35wyq 292 16 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 292 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 292 18 intracellular intracellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 292 19 bridges bridge NNS work_wtnfwgpzqnfabpwucygbl35wyq 292 20 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 292 21 provided provide VBN work_wtnfwgpzqnfabpwucygbl35wyq 292 22 underneath underneath IN work_wtnfwgpzqnfabpwucygbl35wyq 292 23 each each DT work_wtnfwgpzqnfabpwucygbl35wyq 292 24 image image NN work_wtnfwgpzqnfabpwucygbl35wyq 292 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 293 1 α α LS work_wtnfwgpzqnfabpwucygbl35wyq 293 2 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 293 3 tubulin tubulin NNP work_wtnfwgpzqnfabpwucygbl35wyq 293 4 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 293 5 green green JJ work_wtnfwgpzqnfabpwucygbl35wyq 293 6 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 293 7 marks mark VBZ work_wtnfwgpzqnfabpwucygbl35wyq 293 8 mitotic mitotic JJ work_wtnfwgpzqnfabpwucygbl35wyq 293 9 bridges bridge NNS work_wtnfwgpzqnfabpwucygbl35wyq 293 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 293 11 nuclei nucleus NNS work_wtnfwgpzqnfabpwucygbl35wyq 293 12 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 293 13 stained stain VBN work_wtnfwgpzqnfabpwucygbl35wyq 293 14 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 293 15 DAPI dapi NN work_wtnfwgpzqnfabpwucygbl35wyq 293 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 293 17 blue blue NNP work_wtnfwgpzqnfabpwucygbl35wyq 293 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 293 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 294 1 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 294 2 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 294 3 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 294 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 294 5 shown show VBN work_wtnfwgpzqnfabpwucygbl35wyq 294 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 294 7 red red NN work_wtnfwgpzqnfabpwucygbl35wyq 294 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 295 1 Scale scale NN work_wtnfwgpzqnfabpwucygbl35wyq 295 2 bars bar NNS work_wtnfwgpzqnfabpwucygbl35wyq 295 3 represent represent VBP work_wtnfwgpzqnfabpwucygbl35wyq 295 4 10 10 CD work_wtnfwgpzqnfabpwucygbl35wyq 295 5 μm μm NNS work_wtnfwgpzqnfabpwucygbl35wyq 295 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 296 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 296 2 B b NN work_wtnfwgpzqnfabpwucygbl35wyq 296 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 296 4 Histogram Histogram NNP work_wtnfwgpzqnfabpwucygbl35wyq 296 5 showing show VBG work_wtnfwgpzqnfabpwucygbl35wyq 296 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 296 7 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 296 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 296 9 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 296 10 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 296 11 tagged tag VBN work_wtnfwgpzqnfabpwucygbl35wyq 296 12 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 296 13 proteins protein NNS work_wtnfwgpzqnfabpwucygbl35wyq 296 14 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 296 15 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 296 16 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 296 17 following follow VBG work_wtnfwgpzqnfabpwucygbl35wyq 296 18 24 24 CD work_wtnfwgpzqnfabpwucygbl35wyq 296 19 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 296 20 48-hour 48-hour CD work_wtnfwgpzqnfabpwucygbl35wyq 296 21 transfections transfection NNS work_wtnfwgpzqnfabpwucygbl35wyq 296 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 296 23 respectively respectively RB work_wtnfwgpzqnfabpwucygbl35wyq 296 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 297 1 Wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 297 2 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 297 3 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 297 4 mRFP mrfp NN work_wtnfwgpzqnfabpwucygbl35wyq 297 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 297 6 CEP55 cep55 NN work_wtnfwgpzqnfabpwucygbl35wyq 297 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 297 8 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 297 9 - - : work_wtnfwgpzqnfabpwucygbl35wyq 297 10 CEP55 cep55 FW work_wtnfwgpzqnfabpwucygbl35wyq 297 11 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 297 12 polymorphisms polymorphism NNS work_wtnfwgpzqnfabpwucygbl35wyq 297 13 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 297 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 297 15 H57Q h57q NN work_wtnfwgpzqnfabpwucygbl35wyq 297 16 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 297 17 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 297 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 297 19 H378L H378L NNP work_wtnfwgpzqnfabpwucygbl35wyq 297 20 localised localise VBD work_wtnfwgpzqnfabpwucygbl35wyq 297 21 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 297 22 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 297 23 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 297 24 near near IN work_wtnfwgpzqnfabpwucygbl35wyq 297 25 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 297 26 end end NN work_wtnfwgpzqnfabpwucygbl35wyq 297 27 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 297 28 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 297 29 , , , work_wtnfwgpzqnfabpwucygbl35wyq 297 30 while while IN work_wtnfwgpzqnfabpwucygbl35wyq 297 31 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 297 32 mutant mutant NN work_wtnfwgpzqnfabpwucygbl35wyq 297 33 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 297 34 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 297 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 297 36 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 297 37 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 297 38 did do VBD work_wtnfwgpzqnfabpwucygbl35wyq 297 39 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 297 40 . . . work_wtnfwgpzqnfabpwucygbl35wyq 298 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 298 2 differences difference NNS work_wtnfwgpzqnfabpwucygbl35wyq 298 3 between between IN work_wtnfwgpzqnfabpwucygbl35wyq 298 4 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 298 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 298 6 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 298 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 298 8 polymorphisms polymorphism NNS work_wtnfwgpzqnfabpwucygbl35wyq 298 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 298 10 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 298 11 conditions condition NNS work_wtnfwgpzqnfabpwucygbl35wyq 298 12 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 298 13 significant significant JJ work_wtnfwgpzqnfabpwucygbl35wyq 298 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 298 15 p<0.0001 p<0.0001 NN work_wtnfwgpzqnfabpwucygbl35wyq 298 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 298 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 299 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 299 2 number number NN work_wtnfwgpzqnfabpwucygbl35wyq 299 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 299 4 mitotic mitotic JJ work_wtnfwgpzqnfabpwucygbl35wyq 299 5 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 299 6 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 299 7 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 299 8 counted count VBN work_wtnfwgpzqnfabpwucygbl35wyq 299 9 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 299 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 299 11 48-hour 48-hour CD work_wtnfwgpzqnfabpwucygbl35wyq 299 12 transfection transfection NN work_wtnfwgpzqnfabpwucygbl35wyq 299 13 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 299 14 n=52 n=52 VBN work_wtnfwgpzqnfabpwucygbl35wyq 299 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 16 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 299 17 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 299 18 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 299 19 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 299 21 n=51 n=51 NNP work_wtnfwgpzqnfabpwucygbl35wyq 299 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 23 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 299 24 . . . work_wtnfwgpzqnfabpwucygbl35wyq 299 25 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 299 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 299 28 n=50 n=50 NNP work_wtnfwgpzqnfabpwucygbl35wyq 299 29 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 30 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 299 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 299 32 H57Q H57Q NNP work_wtnfwgpzqnfabpwucygbl35wyq 299 33 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 34 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 299 35 n=50 n=50 NNP work_wtnfwgpzqnfabpwucygbl35wyq 299 36 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 37 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 299 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 299 39 H378L h378l ADD work_wtnfwgpzqnfabpwucygbl35wyq 299 40 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 299 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 300 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 300 2 number number NN work_wtnfwgpzqnfabpwucygbl35wyq 300 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 300 4 mitotic mitotic JJ work_wtnfwgpzqnfabpwucygbl35wyq 300 5 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 300 6 analysed analyse VBN work_wtnfwgpzqnfabpwucygbl35wyq 300 7 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 300 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 300 9 24-hour 24-hour CD work_wtnfwgpzqnfabpwucygbl35wyq 300 10 transfection transfection NN work_wtnfwgpzqnfabpwucygbl35wyq 300 11 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 300 12 n=79 n=79 JJ work_wtnfwgpzqnfabpwucygbl35wyq 300 13 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 14 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 300 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 300 16 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 300 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 300 19 n=52 n=52 RB work_wtnfwgpzqnfabpwucygbl35wyq 300 20 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 21 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 300 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 300 23 S425X S425X NNP work_wtnfwgpzqnfabpwucygbl35wyq 300 24 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 300 26 n=62 n=62 NNP work_wtnfwgpzqnfabpwucygbl35wyq 300 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 28 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 300 29 . . . work_wtnfwgpzqnfabpwucygbl35wyq 300 30 H57Q H57Q NNP work_wtnfwgpzqnfabpwucygbl35wyq 300 31 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 32 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 300 33 n=69 n=69 NNP work_wtnfwgpzqnfabpwucygbl35wyq 300 34 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 35 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 300 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 300 37 H378L h378l ADD work_wtnfwgpzqnfabpwucygbl35wyq 300 38 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 300 39 . . . work_wtnfwgpzqnfabpwucygbl35wyq 301 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 301 2 24-hour 24-hour CD work_wtnfwgpzqnfabpwucygbl35wyq 301 3 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 301 4 48-hour 48-hour CD work_wtnfwgpzqnfabpwucygbl35wyq 301 5 transfections transfection NNS work_wtnfwgpzqnfabpwucygbl35wyq 301 6 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 301 7 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 301 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 301 9 duplicate duplicate NNP work_wtnfwgpzqnfabpwucygbl35wyq 301 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 302 1 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 302 2 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 302 3 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 302 4 Western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 302 5 blot blot NN work_wtnfwgpzqnfabpwucygbl35wyq 302 6 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 302 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 302 8 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 302 9 - - : work_wtnfwgpzqnfabpwucygbl35wyq 302 10 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 302 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 302 12 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 302 13 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 302 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 303 1 Lower low JJR work_wtnfwgpzqnfabpwucygbl35wyq 303 2 bands band NNS work_wtnfwgpzqnfabpwucygbl35wyq 303 3 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 303 4 indicated indicate VBN work_wtnfwgpzqnfabpwucygbl35wyq 303 5 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 303 6 * * NFP work_wtnfwgpzqnfabpwucygbl35wyq 303 7 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 303 8 show show VB work_wtnfwgpzqnfabpwucygbl35wyq 303 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 303 10 expected expect VBN work_wtnfwgpzqnfabpwucygbl35wyq 303 11 sizes size NNS work_wtnfwgpzqnfabpwucygbl35wyq 303 12 : : : work_wtnfwgpzqnfabpwucygbl35wyq 303 13 81 81 CD work_wtnfwgpzqnfabpwucygbl35wyq 303 14 kDa kDa NNS work_wtnfwgpzqnfabpwucygbl35wyq 303 15 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 303 16 mRFP mRFP NNP work_wtnfwgpzqnfabpwucygbl35wyq 303 17 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 303 18 fused fuse VBN work_wtnfwgpzqnfabpwucygbl35wyq 303 19 wild wild JJ work_wtnfwgpzqnfabpwucygbl35wyq 303 20 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 303 21 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 303 22 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 303 23 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 303 24 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 303 25 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 303 26 polymorphisms polymorphism NNS work_wtnfwgpzqnfabpwucygbl35wyq 303 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 303 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 303 29 77 77 CD work_wtnfwgpzqnfabpwucygbl35wyq 303 30 kDa kDa NNS work_wtnfwgpzqnfabpwucygbl35wyq 303 31 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 303 32 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 303 33 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 303 34 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 303 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 304 1 No no UH work_wtnfwgpzqnfabpwucygbl35wyq 304 2 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 304 3 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 304 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 304 5 detected detect VBN work_wtnfwgpzqnfabpwucygbl35wyq 304 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 304 7 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 304 8 transfected transfecte VBN work_wtnfwgpzqnfabpwucygbl35wyq 304 9 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 304 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 304 11 empty empty JJ work_wtnfwgpzqnfabpwucygbl35wyq 304 12 vector vector NN work_wtnfwgpzqnfabpwucygbl35wyq 304 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 305 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 305 2 origin origin NN work_wtnfwgpzqnfabpwucygbl35wyq 305 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 305 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 305 5 higher high JJR work_wtnfwgpzqnfabpwucygbl35wyq 305 6 band band NN work_wtnfwgpzqnfabpwucygbl35wyq 305 7 evident evident JJ work_wtnfwgpzqnfabpwucygbl35wyq 305 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 305 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 305 10 first first JJ work_wtnfwgpzqnfabpwucygbl35wyq 305 11 four four CD work_wtnfwgpzqnfabpwucygbl35wyq 305 12 lanes lane NNS work_wtnfwgpzqnfabpwucygbl35wyq 305 13 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 305 14 unclear unclear JJ work_wtnfwgpzqnfabpwucygbl35wyq 305 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 306 1 One one CD work_wtnfwgpzqnfabpwucygbl35wyq 306 2 potential potential JJ work_wtnfwgpzqnfabpwucygbl35wyq 306 3 explanation explanation NN work_wtnfwgpzqnfabpwucygbl35wyq 306 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 306 5 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 306 6 post post JJ work_wtnfwgpzqnfabpwucygbl35wyq 306 7 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 306 8 translational translational JJ work_wtnfwgpzqnfabpwucygbl35wyq 306 9 modification modification NN work_wtnfwgpzqnfabpwucygbl35wyq 306 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 306 11 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 306 12 tagged tag VBN work_wtnfwgpzqnfabpwucygbl35wyq 306 13 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 306 14 occurring occur VBG work_wtnfwgpzqnfabpwucygbl35wyq 306 15 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 306 16 COS-7 COS-7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 306 17 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 306 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 307 1 499Frosk 499Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 307 2   _SP work_wtnfwgpzqnfabpwucygbl35wyq 307 3 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 307 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 307 5 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 307 6   _SP work_wtnfwgpzqnfabpwucygbl35wyq 307 7 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 307 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 308 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 308 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 308 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 308 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 308 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 309 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 309 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 309 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 309 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 309 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 309 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 309 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 309 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 309 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 309 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 309 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 309 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 309 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 309 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 309 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 309 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 309 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 309 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 309 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 309 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 309 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 309 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 309 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 309 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 309 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 309 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 309 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 309 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 309 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 310 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 310 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 310 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 9 d d NN work_wtnfwgpzqnfabpwucygbl35wyq 310 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 12 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 13 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 310 14 against against IN work_wtnfwgpzqnfabpwucygbl35wyq 310 15 hypoxic hypoxic NN work_wtnfwgpzqnfabpwucygbl35wyq 310 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 310 17 excitotoxic excitotoxic JJ work_wtnfwgpzqnfabpwucygbl35wyq 310 18 injury.47–49 injury.47–49 NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 19 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 310 20 similar similar JJ work_wtnfwgpzqnfabpwucygbl35wyq 310 21 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 310 22 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 310 23 involved involve VBN work_wtnfwgpzqnfabpwucygbl35wyq 310 24 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 310 25 ischaemic ischaemic JJ work_wtnfwgpzqnfabpwucygbl35wyq 310 26 damage damage NN work_wtnfwgpzqnfabpwucygbl35wyq 310 27 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 310 28 kidney.50 kidney.50 NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 29 Deficient Deficient NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 30 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 31 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 310 32 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 310 33 signalling signalling NN work_wtnfwgpzqnfabpwucygbl35wyq 310 34 may may MD work_wtnfwgpzqnfabpwucygbl35wyq 310 35 thus thus RB work_wtnfwgpzqnfabpwucygbl35wyq 310 36 help help VB work_wtnfwgpzqnfabpwucygbl35wyq 310 37 explain explain VB work_wtnfwgpzqnfabpwucygbl35wyq 310 38 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 310 39 destructive destructive JJ work_wtnfwgpzqnfabpwucygbl35wyq 310 40 fea- fea- NNS work_wtnfwgpzqnfabpwucygbl35wyq 310 41 tures ture NNS work_wtnfwgpzqnfabpwucygbl35wyq 310 42 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 310 43 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 310 44 brains brain NNS work_wtnfwgpzqnfabpwucygbl35wyq 310 45 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 310 46 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 310 47 fetuses fetus NNS work_wtnfwgpzqnfabpwucygbl35wyq 310 48 affected affect VBN work_wtnfwgpzqnfabpwucygbl35wyq 310 49 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 310 50 MARCH MARCH NNS work_wtnfwgpzqnfabpwucygbl35wyq 310 51 . . . work_wtnfwgpzqnfabpwucygbl35wyq 311 1 Interference interference NN work_wtnfwgpzqnfabpwucygbl35wyq 311 2 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 311 3 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 311 4 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 311 5 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 311 6 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 311 7 signalling signal VBG work_wtnfwgpzqnfabpwucygbl35wyq 311 8 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 311 9 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 311 10 virtue virtue NN work_wtnfwgpzqnfabpwucygbl35wyq 311 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 311 12 mutant mutant JJ work_wtnfwgpzqnfabpwucygbl35wyq 311 13 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 311 14 could could MD work_wtnfwgpzqnfabpwucygbl35wyq 311 15 allow allow VB work_wtnfwgpzqnfabpwucygbl35wyq 311 16 ischaemic ischaemic JJ work_wtnfwgpzqnfabpwucygbl35wyq 311 17 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 311 18 type type NN work_wtnfwgpzqnfabpwucygbl35wyq 311 19 damage damage NN work_wtnfwgpzqnfabpwucygbl35wyq 311 20 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 311 21 vulnerable vulnerable JJ work_wtnfwgpzqnfabpwucygbl35wyq 311 22 organs organ NNS work_wtnfwgpzqnfabpwucygbl35wyq 311 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 311 24 such such JJ work_wtnfwgpzqnfabpwucygbl35wyq 311 25 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 311 26 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 311 27 parts part NNS work_wtnfwgpzqnfabpwucygbl35wyq 311 28 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 311 29 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 311 30 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 311 31 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 311 32 distal distal JJ work_wtnfwgpzqnfabpwucygbl35wyq 311 33 circulation circulation NN work_wtnfwgpzqnfabpwucygbl35wyq 311 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 311 35 thereby thereby RB work_wtnfwgpzqnfabpwucygbl35wyq 311 36 leading lead VBG work_wtnfwgpzqnfabpwucygbl35wyq 311 37 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 311 38 destruction destruction NN work_wtnfwgpzqnfabpwucygbl35wyq 311 39 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 311 40 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 311 41 cerebrum cerebrum NN work_wtnfwgpzqnfabpwucygbl35wyq 311 42 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 311 43 resultant resultant JJ work_wtnfwgpzqnfabpwucygbl35wyq 311 44 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 311 45 . . . work_wtnfwgpzqnfabpwucygbl35wyq 312 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 312 2 summary summary NN work_wtnfwgpzqnfabpwucygbl35wyq 312 3 , , , work_wtnfwgpzqnfabpwucygbl35wyq 312 4 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 312 5 report report VBP work_wtnfwgpzqnfabpwucygbl35wyq 312 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 312 7 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 312 8 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 312 9 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 312 10 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 312 11 com- com- NN work_wtnfwgpzqnfabpwucygbl35wyq 312 12 bines bin VBZ work_wtnfwgpzqnfabpwucygbl35wyq 312 13 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 312 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 312 15 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 312 16 dysplasia dysplasia NNS work_wtnfwgpzqnfabpwucygbl35wyq 312 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 312 18 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 312 19 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 312 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 312 21 syndactyly syndactyly NNP work_wtnfwgpzqnfabpwucygbl35wyq 312 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 312 23 characteristic characteristic JJ work_wtnfwgpzqnfabpwucygbl35wyq 312 24 dysmorphism dysmorphism NN work_wtnfwgpzqnfabpwucygbl35wyq 312 25 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 312 26 we -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 312 27 have have VBP work_wtnfwgpzqnfabpwucygbl35wyq 312 28 named name VBN work_wtnfwgpzqnfabpwucygbl35wyq 312 29 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 312 30 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 312 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 313 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 313 2 provide provide VBP work_wtnfwgpzqnfabpwucygbl35wyq 313 3 evidence evidence NN work_wtnfwgpzqnfabpwucygbl35wyq 313 4 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 313 5 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 313 6 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 313 7 caused cause VBN work_wtnfwgpzqnfabpwucygbl35wyq 313 8 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 313 9 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 313 10 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 313 11 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 313 12 loss loss NN work_wtnfwgpzqnfabpwucygbl35wyq 313 13 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 313 14 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 313 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 313 16 function function NN work_wtnfwgpzqnfabpwucygbl35wyq 313 17 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 313 18 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 313 19 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 313 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 313 21 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 313 22 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 313 23 not not RB work_wtnfwgpzqnfabpwucygbl35wyq 313 24 associated associate VBN work_wtnfwgpzqnfabpwucygbl35wyq 313 25 previously previously RB work_wtnfwgpzqnfabpwucygbl35wyq 313 26 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 313 27 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 313 28 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 313 29 . . . work_wtnfwgpzqnfabpwucygbl35wyq 314 1 Our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 314 2 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 314 3 provide provide VBP work_wtnfwgpzqnfabpwucygbl35wyq 314 4 insight insight NN work_wtnfwgpzqnfabpwucygbl35wyq 314 5 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 314 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 314 7 developmental developmental JJ work_wtnfwgpzqnfabpwucygbl35wyq 314 8 functions function NNS work_wtnfwgpzqnfabpwucygbl35wyq 314 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 314 10 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 314 11 particularly particularly RB work_wtnfwgpzqnfabpwucygbl35wyq 314 12 as as IN work_wtnfwgpzqnfabpwucygbl35wyq 314 13 it -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 314 14 relates relate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 314 15 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 314 16 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 314 17 development development NN work_wtnfwgpzqnfabpwucygbl35wyq 314 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 315 1 Future future JJ work_wtnfwgpzqnfabpwucygbl35wyq 315 2 directions direction NNS work_wtnfwgpzqnfabpwucygbl35wyq 315 3 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 315 4 our -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 315 5 research research NN work_wtnfwgpzqnfabpwucygbl35wyq 315 6 include include VBP work_wtnfwgpzqnfabpwucygbl35wyq 315 7 exploring explore VBG work_wtnfwgpzqnfabpwucygbl35wyq 315 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 315 9 role role NN work_wtnfwgpzqnfabpwucygbl35wyq 315 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 315 11 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 315 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 315 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 315 14 creation creation NN work_wtnfwgpzqnfabpwucygbl35wyq 315 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 315 16 new new JJ work_wtnfwgpzqnfabpwucygbl35wyq 315 17 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 315 18 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 315 19 understanding understand VBG work_wtnfwgpzqnfabpwucygbl35wyq 315 20 how how WRB work_wtnfwgpzqnfabpwucygbl35wyq 315 21 PI3K/ PI3K/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 315 22 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 315 23 may may MD work_wtnfwgpzqnfabpwucygbl35wyq 315 24 be be VB work_wtnfwgpzqnfabpwucygbl35wyq 315 25 involved involve VBN work_wtnfwgpzqnfabpwucygbl35wyq 315 26 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 315 27 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 315 28 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 315 29 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 315 30 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 315 31 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 315 32 other other JJ work_wtnfwgpzqnfabpwucygbl35wyq 315 33 conditions condition NNS work_wtnfwgpzqnfabpwucygbl35wyq 315 34 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 315 35 include include VBP work_wtnfwgpzqnfabpwucygbl35wyq 315 36 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 315 37 anomaly anomaly JJ work_wtnfwgpzqnfabpwucygbl35wyq 315 38 . . . work_wtnfwgpzqnfabpwucygbl35wyq 316 1 We -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 316 2 propose propose VBP work_wtnfwgpzqnfabpwucygbl35wyq 316 3 that that IN work_wtnfwgpzqnfabpwucygbl35wyq 316 4 both both DT work_wtnfwgpzqnfabpwucygbl35wyq 316 5 measuring measure VBG work_wtnfwgpzqnfabpwucygbl35wyq 316 6 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 316 7 activity activity NN work_wtnfwgpzqnfabpwucygbl35wyq 316 8 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 316 9 animal animal NN work_wtnfwgpzqnfabpwucygbl35wyq 316 10 models model NNS work_wtnfwgpzqnfabpwucygbl35wyq 316 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 316 12 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 316 13 dis- dis- IN work_wtnfwgpzqnfabpwucygbl35wyq 316 14 order order NN work_wtnfwgpzqnfabpwucygbl35wyq 316 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 316 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 316 17 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 316 18 testing test VBG work_wtnfwgpzqnfabpwucygbl35wyq 316 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 316 20 hypothesis hypothesis NN work_wtnfwgpzqnfabpwucygbl35wyq 316 21 that that DT work_wtnfwgpzqnfabpwucygbl35wyq 316 22 amelioration amelioration NN work_wtnfwgpzqnfabpwucygbl35wyq 316 23 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 316 24 AKT AKT NNP work_wtnfwgpzqnfabpwucygbl35wyq 316 25 signalling signalling NN work_wtnfwgpzqnfabpwucygbl35wyq 316 26 might may MD work_wtnfwgpzqnfabpwucygbl35wyq 316 27 improve improve VB work_wtnfwgpzqnfabpwucygbl35wyq 316 28 some some DT work_wtnfwgpzqnfabpwucygbl35wyq 316 29 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 316 30 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 316 31 observed observed JJ work_wtnfwgpzqnfabpwucygbl35wyq 316 32 neuroanatom- neuroanatom- JJ work_wtnfwgpzqnfabpwucygbl35wyq 316 33 ical ical JJ work_wtnfwgpzqnfabpwucygbl35wyq 316 34 defects defect NNS work_wtnfwgpzqnfabpwucygbl35wyq 316 35 will will MD work_wtnfwgpzqnfabpwucygbl35wyq 316 36 provide provide VB work_wtnfwgpzqnfabpwucygbl35wyq 316 37 further further JJ work_wtnfwgpzqnfabpwucygbl35wyq 316 38 insight insight NN work_wtnfwgpzqnfabpwucygbl35wyq 316 39 into into IN work_wtnfwgpzqnfabpwucygbl35wyq 316 40 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 316 41 basis basis NN work_wtnfwgpzqnfabpwucygbl35wyq 316 42 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 316 43 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 316 44 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 316 45 . . . work_wtnfwgpzqnfabpwucygbl35wyq 317 1 Author author NN work_wtnfwgpzqnfabpwucygbl35wyq 317 2 affiliations affiliation NNS work_wtnfwgpzqnfabpwucygbl35wyq 317 3 1Departments 1Departments NNPS work_wtnfwgpzqnfabpwucygbl35wyq 317 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 5 Pediatrics Pediatrics NNPS work_wtnfwgpzqnfabpwucygbl35wyq 317 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 317 7 Child Child NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 8 Health Health NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 10 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 11 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 12 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 14 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 15 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 16 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 17 2Departments 2Departments NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 18 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 19 Biochemistry Biochemistry NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 20 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 317 21 Medical Medical NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 22 Genetics Genetics NNPS work_wtnfwgpzqnfabpwucygbl35wyq 317 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 24 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 25 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 26 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 28 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 29 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 30 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 31 3Departments 3Departments NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 32 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 33 Biochemistry Biochemistry NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 35 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 36 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 37 Western Western NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 38 Ontario Ontario NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 40 London London NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 41 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 42 Ontario Ontario NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 43 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 44 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 45 4Department 4department NN work_wtnfwgpzqnfabpwucygbl35wyq 317 46 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 47 Human Human NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 48 Genetics Genetics NNPS work_wtnfwgpzqnfabpwucygbl35wyq 317 49 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 50 Radboudumc Radboudumc NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 51 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 52 Nijmegen Nijmegen NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 53 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 54 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 317 55 Netherlands Netherlands NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 56 5Center 5Center NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 57 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 317 58 Human Human NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 59 Disease Disease NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 60 Modeling Modeling NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 61 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 62 Duke Duke NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 63 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 64 Medical Medical NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 65 Center Center NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 66 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 67 Durham Durham NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 68 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 69 North North NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 70 Carolina Carolina NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 71 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 72 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 73 6McGill 6McGill NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 74 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 75 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 317 76 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 77 Quebec Quebec NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 78 Innovation Innovation NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 79 Centre Centre NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 80 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 81 Montreal Montreal NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 82 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 83 Quebec Quebec NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 84 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 85 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 86 7Departments 7Departments NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 87 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 88 Medicine Medicine NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 89 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 90 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 91 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 92 Western Western NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 93 Ontario Ontario NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 94 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 95 London London NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 96 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 97 Ontario Ontario NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 98 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 99 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 100 8Departments 8Departments NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 101 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 102 Pathology Pathology NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 103 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 104 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 105 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 317 106 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 107 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 108 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 109 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 110 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 111 9Diagnostic 9Diagnostic NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 112 Services Services NNPS work_wtnfwgpzqnfabpwucygbl35wyq 317 113 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 114 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 115 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 116 , , , work_wtnfwgpzqnfabpwucygbl35wyq 317 117 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 317 118 Acknowledgements acknowledgement VBZ work_wtnfwgpzqnfabpwucygbl35wyq 317 119 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 317 120 authors author NNS work_wtnfwgpzqnfabpwucygbl35wyq 317 121 thank thank VBP work_wtnfwgpzqnfabpwucygbl35wyq 317 122 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 317 123 family family NN work_wtnfwgpzqnfabpwucygbl35wyq 317 124 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 317 125 agreeing agree VBG work_wtnfwgpzqnfabpwucygbl35wyq 317 126 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 317 127 allow allow VB work_wtnfwgpzqnfabpwucygbl35wyq 317 128 them -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 317 129 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 317 130 publish publish VB work_wtnfwgpzqnfabpwucygbl35wyq 317 131 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 317 132 research research NN work_wtnfwgpzqnfabpwucygbl35wyq 317 133 . . . work_wtnfwgpzqnfabpwucygbl35wyq 318 1 They -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 318 2 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 318 3 acknowledge acknowledge VBP work_wtnfwgpzqnfabpwucygbl35wyq 318 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 318 5 contribution contribution NN work_wtnfwgpzqnfabpwucygbl35wyq 318 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 318 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 318 8 high high JJ work_wtnfwgpzqnfabpwucygbl35wyq 318 9 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 318 10 throughput throughput NN work_wtnfwgpzqnfabpwucygbl35wyq 318 11 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 318 12 platform platform NN work_wtnfwgpzqnfabpwucygbl35wyq 318 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 318 14 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 318 15 McGill McGill NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 16 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 17 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 318 18 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 19 Quebec Quebec NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 20 Innovation Innovation NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 21 Centre Centre NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 318 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 318 24 Centre Centre NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 25 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 318 26 Applied Applied NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 27 Genomics Genomics NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 318 29 Toronto Toronto NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 318 31 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 318 33 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 318 34 SNP SNP NNP work_wtnfwgpzqnfabpwucygbl35wyq 318 35 genotyping genotyping NN work_wtnfwgpzqnfabpwucygbl35wyq 318 36 . . . work_wtnfwgpzqnfabpwucygbl35wyq 319 1 They -PRON- PRP work_wtnfwgpzqnfabpwucygbl35wyq 319 2 further further RB work_wtnfwgpzqnfabpwucygbl35wyq 319 3 thank thank VBP work_wtnfwgpzqnfabpwucygbl35wyq 319 4 H. H. NNP work_wtnfwgpzqnfabpwucygbl35wyq 319 5 Almadhoun Almadhoun NNP work_wtnfwgpzqnfabpwucygbl35wyq 319 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 319 7 S.M. S.M. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 1 Farhan Farhan NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 3 J. J. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 4 Wang Wang NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 6 M. M. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 7 Ban Ban NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 9 J. J. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 10 Robinson Robinson NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 12 J. J. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 13 Samsoondar Samsoondar NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 15 C. C. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 16 O’Neil O’Neil NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 18 V. V. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 19 Ly Ly NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 320 22 X. X. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 23 Mao Mao NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 24 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 320 25 technical technical JJ work_wtnfwgpzqnfabpwucygbl35wyq 320 26 assistance assistance NN work_wtnfwgpzqnfabpwucygbl35wyq 320 27 and/or and/or CC work_wtnfwgpzqnfabpwucygbl35wyq 320 28 discussions discussion NNS work_wtnfwgpzqnfabpwucygbl35wyq 320 29 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 30 S. S. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 31 Phillips Phillips NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 32 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 320 33 postmortem postmortem NN work_wtnfwgpzqnfabpwucygbl35wyq 320 34 examination examination NN work_wtnfwgpzqnfabpwucygbl35wyq 320 35 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 36 R. R. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 37 Roepman Roepman NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 38 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 320 39 vectors vector NNS work_wtnfwgpzqnfabpwucygbl35wyq 320 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 41 G. G. NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 42 Pickering Pickering NNP work_wtnfwgpzqnfabpwucygbl35wyq 320 43 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 320 44 use use NN work_wtnfwgpzqnfabpwucygbl35wyq 320 45 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 320 46 laboratory laboratory NN work_wtnfwgpzqnfabpwucygbl35wyq 320 47 equipment equipment NN work_wtnfwgpzqnfabpwucygbl35wyq 320 48 , , , work_wtnfwgpzqnfabpwucygbl35wyq 320 49 V.M. V.M. NNP work_wtnfwgpzqnfabpwucygbl35wyq 321 1 Siu Siu NNP work_wtnfwgpzqnfabpwucygbl35wyq 321 2 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 321 3 her -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 321 4 ethics ethic NNS work_wtnfwgpzqnfabpwucygbl35wyq 321 5 contribution contribution NN work_wtnfwgpzqnfabpwucygbl35wyq 321 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 321 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 321 8 L. L. NNP work_wtnfwgpzqnfabpwucygbl35wyq 321 9 Gyenis Gyenis NNP work_wtnfwgpzqnfabpwucygbl35wyq 321 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 321 11 D.W. D.W. NNP work_wtnfwgpzqnfabpwucygbl35wyq 321 12 Litchfield Litchfield NNP work_wtnfwgpzqnfabpwucygbl35wyq 321 13 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 321 14 scientific scientific JJ work_wtnfwgpzqnfabpwucygbl35wyq 321 15 input input NN work_wtnfwgpzqnfabpwucygbl35wyq 321 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 322 1 Collaborators collaborator NNS work_wtnfwgpzqnfabpwucygbl35wyq 322 2 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 3 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 4 Consortium Consortium NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 5 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 322 6 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 7 Steering Steering NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 8 Committee Committee NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 9 membership membership NN work_wtnfwgpzqnfabpwucygbl35wyq 322 10 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 322 11 listed list VBN work_wtnfwgpzqnfabpwucygbl35wyq 322 12 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 322 13 Supplement Supplement NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 14 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 322 15 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 322 16 Canadian Canadian NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 17 Rare Rare NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 18 Diseases Diseases NNPS work_wtnfwgpzqnfabpwucygbl35wyq 322 19 : : : work_wtnfwgpzqnfabpwucygbl35wyq 322 20 Models Models NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 21 & & CC work_wtnfwgpzqnfabpwucygbl35wyq 322 22 Mechanisms Mechanisms NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 23 Network Network NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 24 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 322 25 Canadian Canadian NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 26 Rare Rare NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 27 Diseases Diseases NNPS work_wtnfwgpzqnfabpwucygbl35wyq 322 28 : : : work_wtnfwgpzqnfabpwucygbl35wyq 322 29 Models Models NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 30 & & CC work_wtnfwgpzqnfabpwucygbl35wyq 322 31 Mechanisms Mechanisms NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 32 Network Network NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 33 Committee Committee NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 34 memberships membership NNS work_wtnfwgpzqnfabpwucygbl35wyq 322 35 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 322 36 listed list VBN work_wtnfwgpzqnfabpwucygbl35wyq 322 37 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 322 38 Supplement Supplement NNP work_wtnfwgpzqnfabpwucygbl35wyq 322 39 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 322 40 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 322 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 323 1 Contributors Contributors NNP work_wtnfwgpzqnfabpwucygbl35wyq 323 2 PF PF NNP work_wtnfwgpzqnfabpwucygbl35wyq 323 3 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 323 4 HHA HHA NNP work_wtnfwgpzqnfabpwucygbl35wyq 323 5 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 323 6 equally equally RB work_wtnfwgpzqnfabpwucygbl35wyq 323 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 324 1 PF PF NNP work_wtnfwgpzqnfabpwucygbl35wyq 324 2 provided provide VBD work_wtnfwgpzqnfabpwucygbl35wyq 324 3 clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 324 4 care care NN work_wtnfwgpzqnfabpwucygbl35wyq 324 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 324 6 designed design VBD work_wtnfwgpzqnfabpwucygbl35wyq 324 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 324 8 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 324 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 324 10 performed perform VBD work_wtnfwgpzqnfabpwucygbl35wyq 324 11 homozygosity homozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 324 12 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 324 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 324 14 wrote write VBD work_wtnfwgpzqnfabpwucygbl35wyq 324 15 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 324 16 initial initial JJ work_wtnfwgpzqnfabpwucygbl35wyq 324 17 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 324 18 . . . work_wtnfwgpzqnfabpwucygbl35wyq 325 1 HHA HHA NNP work_wtnfwgpzqnfabpwucygbl35wyq 325 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 325 3 RH RH NNP work_wtnfwgpzqnfabpwucygbl35wyq 325 4 performed perform VBD work_wtnfwgpzqnfabpwucygbl35wyq 325 5 confocal confocal JJ work_wtnfwgpzqnfabpwucygbl35wyq 325 6 microscopy microscopy NN work_wtnfwgpzqnfabpwucygbl35wyq 325 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 325 8 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 325 9 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 325 10 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 325 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 325 12 aided aid VBN work_wtnfwgpzqnfabpwucygbl35wyq 325 13 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 325 14 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 325 15 design design NN work_wtnfwgpzqnfabpwucygbl35wyq 325 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 325 17 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 325 18 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 325 19 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 325 20 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 325 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 326 1 JP JP NNP work_wtnfwgpzqnfabpwucygbl35wyq 326 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 326 3 CSG CSG NNP work_wtnfwgpzqnfabpwucygbl35wyq 326 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 326 5 CR CR NNP work_wtnfwgpzqnfabpwucygbl35wyq 326 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 326 7 YPL YPL NNP work_wtnfwgpzqnfabpwucygbl35wyq 326 8 performed perform VBD work_wtnfwgpzqnfabpwucygbl35wyq 326 9 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 326 10 experiments experiment NNS work_wtnfwgpzqnfabpwucygbl35wyq 326 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 326 12 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 326 13 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 326 14 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 326 15 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 326 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 327 1 ELB ELB NNP work_wtnfwgpzqnfabpwucygbl35wyq 327 2 performed perform VBN work_wtnfwgpzqnfabpwucygbl35wyq 327 3 confocal confocal NN work_wtnfwgpzqnfabpwucygbl35wyq 327 4 microscopy microscopy NN work_wtnfwgpzqnfabpwucygbl35wyq 327 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 327 6 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 327 7 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 327 8 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 327 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 327 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 327 11 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 327 12 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 327 13 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 327 14 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 327 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 328 1 BC BC NNP work_wtnfwgpzqnfabpwucygbl35wyq 328 2 provided provide VBD work_wtnfwgpzqnfabpwucygbl35wyq 328 3 clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 328 4 care care NN work_wtnfwgpzqnfabpwucygbl35wyq 328 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 328 6 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 328 7 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 328 8 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 328 9 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 328 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 329 1 LS LS NNP work_wtnfwgpzqnfabpwucygbl35wyq 329 2 performed perform VBD work_wtnfwgpzqnfabpwucygbl35wyq 329 3 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 329 4 validation validation NN work_wtnfwgpzqnfabpwucygbl35wyq 329 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 329 6 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 329 7 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 329 8 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 329 9 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 329 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 330 1 JM JM NNP work_wtnfwgpzqnfabpwucygbl35wyq 330 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 330 3 SF SF NNP work_wtnfwgpzqnfabpwucygbl35wyq 330 4 provided provide VBD work_wtnfwgpzqnfabpwucygbl35wyq 330 5 bioinformatics bioinformatic NNS work_wtnfwgpzqnfabpwucygbl35wyq 330 6 support support NN work_wtnfwgpzqnfabpwucygbl35wyq 330 7 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 330 8 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 330 9 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 330 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 330 11 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 330 12 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 330 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 331 1 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 331 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 331 3 RDMM RDMM NNP work_wtnfwgpzqnfabpwucygbl35wyq 331 4 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 331 5 consortia consortium NNS work_wtnfwgpzqnfabpwucygbl35wyq 331 6 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 331 7 supported support VBD work_wtnfwgpzqnfabpwucygbl35wyq 331 8 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 331 9 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 331 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 331 11 members member NNS work_wtnfwgpzqnfabpwucygbl35wyq 331 12 were be VBD work_wtnfwgpzqnfabpwucygbl35wyq 331 13 involved involve VBN work_wtnfwgpzqnfabpwucygbl35wyq 331 14 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 331 15 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 331 16 identification identification NN work_wtnfwgpzqnfabpwucygbl35wyq 331 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 331 18 connecting connect VBG work_wtnfwgpzqnfabpwucygbl35wyq 331 19 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 331 20 collaborating collaborate VBG work_wtnfwgpzqnfabpwucygbl35wyq 331 21 authors author NNS work_wtnfwgpzqnfabpwucygbl35wyq 331 22 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 331 23 providing provide VBG work_wtnfwgpzqnfabpwucygbl35wyq 331 24 feedback feedback NN work_wtnfwgpzqnfabpwucygbl35wyq 331 25 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 331 26 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 331 27 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 331 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 332 1 NK NK NNP work_wtnfwgpzqnfabpwucygbl35wyq 332 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 332 3 EED EED NNP work_wtnfwgpzqnfabpwucygbl35wyq 332 4 designed design VBD work_wtnfwgpzqnfabpwucygbl35wyq 332 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 332 6 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 332 7 experiments experiment NNS work_wtnfwgpzqnfabpwucygbl35wyq 332 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 332 9 aided aid VBN work_wtnfwgpzqnfabpwucygbl35wyq 332 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 332 11 overall overall JJ work_wtnfwgpzqnfabpwucygbl35wyq 332 12 study study NN work_wtnfwgpzqnfabpwucygbl35wyq 332 13 design design NN work_wtnfwgpzqnfabpwucygbl35wyq 332 14 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 332 15 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 332 16 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 332 17 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 332 18 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 332 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 333 1 CG CG NNP work_wtnfwgpzqnfabpwucygbl35wyq 333 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 333 3 MRDB MRDB NNP work_wtnfwgpzqnfabpwucygbl35wyq 333 4 performed perform VBD work_wtnfwgpzqnfabpwucygbl35wyq 333 5 neuropathological neuropathological JJ work_wtnfwgpzqnfabpwucygbl35wyq 333 6 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 333 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 333 8 immunohistochemistry immunohistochemistry NN work_wtnfwgpzqnfabpwucygbl35wyq 333 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 333 10 western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 333 11 blotting blotting NN work_wtnfwgpzqnfabpwucygbl35wyq 333 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 333 13 contributed contribute VBD work_wtnfwgpzqnfabpwucygbl35wyq 333 14 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 333 15 manuscript manuscript NN work_wtnfwgpzqnfabpwucygbl35wyq 333 16 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 333 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 334 1 Funding fund VBG work_wtnfwgpzqnfabpwucygbl35wyq 334 2 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 334 3 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 334 4 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 334 5 supported support VBN work_wtnfwgpzqnfabpwucygbl35wyq 334 6 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 334 7 part part NN work_wtnfwgpzqnfabpwucygbl35wyq 334 8 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 334 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 334 10 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 11 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 12 consortium consortium NN work_wtnfwgpzqnfabpwucygbl35wyq 334 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 334 14 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 334 15 catalyst catalyst NN work_wtnfwgpzqnfabpwucygbl35wyq 334 16 grant grant NN work_wtnfwgpzqnfabpwucygbl35wyq 334 17 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 334 18 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 334 19 Canadian Canadian NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 20 Rare Rare NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 21 Diseases Diseases NNPS work_wtnfwgpzqnfabpwucygbl35wyq 334 22 : : : work_wtnfwgpzqnfabpwucygbl35wyq 334 23 Models Models NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 24 & & CC work_wtnfwgpzqnfabpwucygbl35wyq 334 25 Mechanisms Mechanisms NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 26 Network Network NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 27 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 334 28 RDMM RDMM NNP work_wtnfwgpzqnfabpwucygbl35wyq 334 29 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 334 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 335 1 Both both DT work_wtnfwgpzqnfabpwucygbl35wyq 335 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 335 3 these these DT work_wtnfwgpzqnfabpwucygbl35wyq 335 4 initiatives initiative NNS work_wtnfwgpzqnfabpwucygbl35wyq 335 5 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 335 6 funded fund VBN work_wtnfwgpzqnfabpwucygbl35wyq 335 7 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 335 8 grants grant NNS work_wtnfwgpzqnfabpwucygbl35wyq 335 9 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 335 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 335 11 Canadian Canadian NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 12 Institutes Institutes NNPS work_wtnfwgpzqnfabpwucygbl35wyq 335 13 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 335 14 Health Health NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 15 Research Research NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 335 17 CIHR CIHR NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 335 19 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 335 20 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 21 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 22 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 335 23 additional additional JJ work_wtnfwgpzqnfabpwucygbl35wyq 335 24 funding funding NN work_wtnfwgpzqnfabpwucygbl35wyq 335 25 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 335 26 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 27 being be VBG work_wtnfwgpzqnfabpwucygbl35wyq 335 28 provided provide VBN work_wtnfwgpzqnfabpwucygbl35wyq 335 29 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 335 30 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 335 31 Ontario Ontario NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 32 Genomics Genomics NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 33 Institute Institute NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 335 35 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 36 Quebec Quebec NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 335 38 Genome Genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 39 British British NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 40 Columbia Columbia NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 41 , , , work_wtnfwgpzqnfabpwucygbl35wyq 335 42 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 335 43 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 335 44 McLaughlin McLaughlin NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 45 Centre Centre NNP work_wtnfwgpzqnfabpwucygbl35wyq 335 46 . . . work_wtnfwgpzqnfabpwucygbl35wyq 336 1 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 336 2 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 336 3 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 336 4 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 336 5 supported support VBN work_wtnfwgpzqnfabpwucygbl35wyq 336 6 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 336 7 US US NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 8 NIH NIH NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 9 grants grant NNS work_wtnfwgpzqnfabpwucygbl35wyq 336 10 DK096415 DK096415 NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 336 12 DK075972 DK075972 NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 336 14 HD042601 HD042601 NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 15 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 336 16 NK NK NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 17 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 336 18 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 336 19 DK072301 DK072301 NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 20 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 336 21 DK096493 DK096493 NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 22 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 336 23 NK NK NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 24 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 336 25 EED EED NNP work_wtnfwgpzqnfabpwucygbl35wyq 336 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 336 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 337 1 PF PF NNS work_wtnfwgpzqnfabpwucygbl35wyq 337 2 received receive VBD work_wtnfwgpzqnfabpwucygbl35wyq 337 3 support support NN work_wtnfwgpzqnfabpwucygbl35wyq 337 4 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 337 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 337 6 Rare Rare NNP work_wtnfwgpzqnfabpwucygbl35wyq 337 7 Disease Disease NNP work_wtnfwgpzqnfabpwucygbl35wyq 337 8 Foundation Foundation NNP work_wtnfwgpzqnfabpwucygbl35wyq 337 9 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 337 10 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 337 11 B.C. B.C. NNP work_wtnfwgpzqnfabpwucygbl35wyq 338 1 Children Children NNP work_wtnfwgpzqnfabpwucygbl35wyq 338 2 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 338 3 Hospital Hospital NNP work_wtnfwgpzqnfabpwucygbl35wyq 338 4 Foundation Foundation NNP work_wtnfwgpzqnfabpwucygbl35wyq 338 5 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 338 6 P#46 P#46 NNP work_wtnfwgpzqnfabpwucygbl35wyq 338 7 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 338 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 339 1 HHA HHA NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 2 also also RB work_wtnfwgpzqnfabpwucygbl35wyq 339 3 received receive VBD work_wtnfwgpzqnfabpwucygbl35wyq 339 4 support support NN work_wtnfwgpzqnfabpwucygbl35wyq 339 5 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 339 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 339 7 Netherlands Netherlands NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 8 Organization Organization NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 9 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 339 10 Scientific Scientific NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 11 Research Research NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 12 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 339 13 NWO NWO NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 14 Veni-91613008 veni-91613008 XX work_wtnfwgpzqnfabpwucygbl35wyq 339 15 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 339 16 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 339 17 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 339 18 Dutch Dutch NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 19 Kidney Kidney NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 20 Foundation Foundation NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 21 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 339 22 CP11.18 CP11.18 NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 23 ‘ ' `` work_wtnfwgpzqnfabpwucygbl35wyq 339 24 KOUNCIL KOUNCIL NNP work_wtnfwgpzqnfabpwucygbl35wyq 339 25 ’ ' '' work_wtnfwgpzqnfabpwucygbl35wyq 339 26 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 339 27 . . . work_wtnfwgpzqnfabpwucygbl35wyq 340 1 MRDB MRDB NNP work_wtnfwgpzqnfabpwucygbl35wyq 340 2 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 340 3 supported support VBN work_wtnfwgpzqnfabpwucygbl35wyq 340 4 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 340 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 340 6 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 340 7 Research Research NNP work_wtnfwgpzqnfabpwucygbl35wyq 340 8 Chair Chair NNP work_wtnfwgpzqnfabpwucygbl35wyq 340 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 340 10 Developmental Developmental NNP work_wtnfwgpzqnfabpwucygbl35wyq 340 11 Neuropathology Neuropathology NNP work_wtnfwgpzqnfabpwucygbl35wyq 340 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 341 1 CSG CSG NNP work_wtnfwgpzqnfabpwucygbl35wyq 341 2 was be VBD work_wtnfwgpzqnfabpwucygbl35wyq 341 3 supported support VBN work_wtnfwgpzqnfabpwucygbl35wyq 341 4 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 341 5 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 341 6 summer summer NN work_wtnfwgpzqnfabpwucygbl35wyq 341 7 studentship studentship NN work_wtnfwgpzqnfabpwucygbl35wyq 341 8 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 341 9 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 341 10 Children Children NNPS work_wtnfwgpzqnfabpwucygbl35wyq 341 11 ’s ’s POS work_wtnfwgpzqnfabpwucygbl35wyq 341 12 Hospital Hospital NNP work_wtnfwgpzqnfabpwucygbl35wyq 341 13 Research Research NNP work_wtnfwgpzqnfabpwucygbl35wyq 341 14 Institute Institute NNP work_wtnfwgpzqnfabpwucygbl35wyq 341 15 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 341 16 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 341 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 342 1 NK NK NNP work_wtnfwgpzqnfabpwucygbl35wyq 342 2 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 342 3 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 342 4 distinguished distinguished JJ work_wtnfwgpzqnfabpwucygbl35wyq 342 5 Jean Jean NNP work_wtnfwgpzqnfabpwucygbl35wyq 342 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 342 7 George George NNP work_wtnfwgpzqnfabpwucygbl35wyq 342 8 Brumley Brumley NNP work_wtnfwgpzqnfabpwucygbl35wyq 342 9 Professor Professor NNP work_wtnfwgpzqnfabpwucygbl35wyq 342 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 343 1 Competing compete VBG work_wtnfwgpzqnfabpwucygbl35wyq 343 2 interests interest NNS work_wtnfwgpzqnfabpwucygbl35wyq 343 3 None none NN work_wtnfwgpzqnfabpwucygbl35wyq 343 4 declared declare VBD work_wtnfwgpzqnfabpwucygbl35wyq 343 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 344 1 Patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 344 2 consent consent NN work_wtnfwgpzqnfabpwucygbl35wyq 344 3 Obtained obtain VBN work_wtnfwgpzqnfabpwucygbl35wyq 344 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 345 1 Ethics Ethics NNP work_wtnfwgpzqnfabpwucygbl35wyq 345 2 approval approval NN work_wtnfwgpzqnfabpwucygbl35wyq 345 3 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 345 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 345 5 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 345 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 346 1 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 346 3 Manitoba Manitoba NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 346 5 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 6 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 346 7 Ottawa Ottawa NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 346 9 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 10 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 346 11 Western Western NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 12 Ontario Ontario NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 346 14 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 346 15 McGill McGill NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 16 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 346 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 347 1 Provenance provenance NN work_wtnfwgpzqnfabpwucygbl35wyq 347 2 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 347 3 peer peer NN work_wtnfwgpzqnfabpwucygbl35wyq 347 4 review review NN work_wtnfwgpzqnfabpwucygbl35wyq 347 5 Not not RB work_wtnfwgpzqnfabpwucygbl35wyq 347 6 commissioned commission VBN work_wtnfwgpzqnfabpwucygbl35wyq 347 7 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 347 8 externally externally RB work_wtnfwgpzqnfabpwucygbl35wyq 347 9 peer peer NN work_wtnfwgpzqnfabpwucygbl35wyq 347 10 reviewed review VBD work_wtnfwgpzqnfabpwucygbl35wyq 347 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 348 1 Open open JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 2 Access access NN work_wtnfwgpzqnfabpwucygbl35wyq 348 3 This this DT work_wtnfwgpzqnfabpwucygbl35wyq 348 4 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 348 5 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 348 6 Open open JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 7 Access access NN work_wtnfwgpzqnfabpwucygbl35wyq 348 8 article article NN work_wtnfwgpzqnfabpwucygbl35wyq 348 9 distributed distribute VBN work_wtnfwgpzqnfabpwucygbl35wyq 348 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 348 11 accordance accordance NN work_wtnfwgpzqnfabpwucygbl35wyq 348 12 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 348 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 348 14 Creative Creative NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 15 Commons Commons NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 16 Attribution Attribution NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 17 Non Non NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 18 Commercial Commercial NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 19 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 348 20 CC CC NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 21 BY BY NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 22 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 348 23 NC NC NNP work_wtnfwgpzqnfabpwucygbl35wyq 348 24 4.0 4.0 CD work_wtnfwgpzqnfabpwucygbl35wyq 348 25 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 348 26 license license NN work_wtnfwgpzqnfabpwucygbl35wyq 348 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 348 28 which which WDT work_wtnfwgpzqnfabpwucygbl35wyq 348 29 permits permit VBZ work_wtnfwgpzqnfabpwucygbl35wyq 348 30 others other NNS work_wtnfwgpzqnfabpwucygbl35wyq 348 31 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 348 32 distribute distribute VB work_wtnfwgpzqnfabpwucygbl35wyq 348 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 348 34 remix remix VBP work_wtnfwgpzqnfabpwucygbl35wyq 348 35 , , , work_wtnfwgpzqnfabpwucygbl35wyq 348 36 adapt adapt NNS work_wtnfwgpzqnfabpwucygbl35wyq 348 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 348 38 build build VBP work_wtnfwgpzqnfabpwucygbl35wyq 348 39 upon upon IN work_wtnfwgpzqnfabpwucygbl35wyq 348 40 this this DT work_wtnfwgpzqnfabpwucygbl35wyq 348 41 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 348 42 non non JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 43 - - NN work_wtnfwgpzqnfabpwucygbl35wyq 348 44 commercially commercially RB work_wtnfwgpzqnfabpwucygbl35wyq 348 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 348 46 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 348 47 license license VB work_wtnfwgpzqnfabpwucygbl35wyq 348 48 their -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 348 49 derivative derivative JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 50 works work NNS work_wtnfwgpzqnfabpwucygbl35wyq 348 51 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 348 52 different different JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 53 terms term NNS work_wtnfwgpzqnfabpwucygbl35wyq 348 54 , , , work_wtnfwgpzqnfabpwucygbl35wyq 348 55 provided provide VBD work_wtnfwgpzqnfabpwucygbl35wyq 348 56 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 348 57 original original JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 58 work work NN work_wtnfwgpzqnfabpwucygbl35wyq 348 59 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 348 60 properly properly RB work_wtnfwgpzqnfabpwucygbl35wyq 348 61 cited cite VBN work_wtnfwgpzqnfabpwucygbl35wyq 348 62 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 348 63 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 348 64 use use NN work_wtnfwgpzqnfabpwucygbl35wyq 348 65 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 348 66 non non JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 67 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 68 commercial commercial JJ work_wtnfwgpzqnfabpwucygbl35wyq 348 69 . . . work_wtnfwgpzqnfabpwucygbl35wyq 349 1 See see VB work_wtnfwgpzqnfabpwucygbl35wyq 349 2 : : : work_wtnfwgpzqnfabpwucygbl35wyq 349 3 http://creativecommons.org/ http://creativecommons.org/ NN work_wtnfwgpzqnfabpwucygbl35wyq 349 4 licenses license NNS work_wtnfwgpzqnfabpwucygbl35wyq 349 5 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 349 6 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 349 7 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 349 8 nc/4.0/ nc/4.0/ NN work_wtnfwgpzqnfabpwucygbl35wyq 349 9 REFERENCES reference NNS work_wtnfwgpzqnfabpwucygbl35wyq 349 10 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 349 11 Dixon Dixon NNP work_wtnfwgpzqnfabpwucygbl35wyq 349 12 A. A. NNP work_wtnfwgpzqnfabpwucygbl35wyq 349 13 Hydranencephaly Hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 349 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 350 1 Radiography radiography NN work_wtnfwgpzqnfabpwucygbl35wyq 350 2 1988;54:12–13 1988;54:12–13 CD work_wtnfwgpzqnfabpwucygbl35wyq 350 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 351 1 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 351 2 Stevenson Stevenson NNP work_wtnfwgpzqnfabpwucygbl35wyq 351 3 RE RE NNP work_wtnfwgpzqnfabpwucygbl35wyq 351 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 351 5 Hall Hall NNP work_wtnfwgpzqnfabpwucygbl35wyq 351 6 JG JG NNP work_wtnfwgpzqnfabpwucygbl35wyq 351 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 352 1 Hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 352 2 . . . work_wtnfwgpzqnfabpwucygbl35wyq 353 1 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 353 2 : : : work_wtnfwgpzqnfabpwucygbl35wyq 353 3 Stevenson Stevenson NNP work_wtnfwgpzqnfabpwucygbl35wyq 353 4 RE RE NNP work_wtnfwgpzqnfabpwucygbl35wyq 353 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 353 6 Hall Hall NNP work_wtnfwgpzqnfabpwucygbl35wyq 353 7 JG JG NNP work_wtnfwgpzqnfabpwucygbl35wyq 353 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 353 9 eds eds XX work_wtnfwgpzqnfabpwucygbl35wyq 353 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 354 1 Human Human NNP work_wtnfwgpzqnfabpwucygbl35wyq 354 2 Malformations Malformations NNPS work_wtnfwgpzqnfabpwucygbl35wyq 354 3 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 354 4 Related Related NNP work_wtnfwgpzqnfabpwucygbl35wyq 354 5 Anomalies Anomalies NNPS work_wtnfwgpzqnfabpwucygbl35wyq 354 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 355 1 Oxford Oxford NNP work_wtnfwgpzqnfabpwucygbl35wyq 355 2 Monographs Monographs NNP work_wtnfwgpzqnfabpwucygbl35wyq 355 3 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 355 4 Medical Medical NNP work_wtnfwgpzqnfabpwucygbl35wyq 355 5 Genetics Genetics NNPS work_wtnfwgpzqnfabpwucygbl35wyq 355 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 356 1 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 356 2 : : : work_wtnfwgpzqnfabpwucygbl35wyq 356 3 Oxford Oxford NNP work_wtnfwgpzqnfabpwucygbl35wyq 356 4 University University NNP work_wtnfwgpzqnfabpwucygbl35wyq 356 5 Press Press NNP work_wtnfwgpzqnfabpwucygbl35wyq 356 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 356 7 2006:639 2006:639 CD work_wtnfwgpzqnfabpwucygbl35wyq 356 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 357 1 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 357 2 Najafzadeh Najafzadeh NNP work_wtnfwgpzqnfabpwucygbl35wyq 357 3 TM TM NNP work_wtnfwgpzqnfabpwucygbl35wyq 357 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 357 5 Reinisch Reinisch NNP work_wtnfwgpzqnfabpwucygbl35wyq 357 6 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 357 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 357 8 Dumars Dumars NNP work_wtnfwgpzqnfabpwucygbl35wyq 357 9 KW KW NNP work_wtnfwgpzqnfabpwucygbl35wyq 357 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 358 1 Etiologic etiologic JJ work_wtnfwgpzqnfabpwucygbl35wyq 358 2 heterogeneity heterogeneity NN work_wtnfwgpzqnfabpwucygbl35wyq 358 3 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 358 4 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 358 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 359 1 Birth birth NN work_wtnfwgpzqnfabpwucygbl35wyq 359 2 Defects Defects NNP work_wtnfwgpzqnfabpwucygbl35wyq 359 3 Orig Orig NNP work_wtnfwgpzqnfabpwucygbl35wyq 359 4 Artic Artic NNP work_wtnfwgpzqnfabpwucygbl35wyq 359 5 Ser Ser NNP work_wtnfwgpzqnfabpwucygbl35wyq 359 6 1982;18:229–35 1982;18:229–35 NNP work_wtnfwgpzqnfabpwucygbl35wyq 359 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 360 1 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 360 2 Cecchetto Cecchetto NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 3 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 360 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 360 5 Milanese milanese JJ work_wtnfwgpzqnfabpwucygbl35wyq 360 6 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 360 8 Giordano Giordano NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 9 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 360 11 Viero Viero NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 12 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 360 14 Suma Suma NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 15 V V NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 360 17 Manara Manara NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 18 R. R. NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 19 Looking look VBG work_wtnfwgpzqnfabpwucygbl35wyq 360 20 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 360 21 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 360 22 missing miss VBG work_wtnfwgpzqnfabpwucygbl35wyq 360 23 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 360 24 : : : work_wtnfwgpzqnfabpwucygbl35wyq 360 25 hydranencephaly hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 26 case case NN work_wtnfwgpzqnfabpwucygbl35wyq 360 27 series series NNP work_wtnfwgpzqnfabpwucygbl35wyq 360 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 360 29 literature literature NN work_wtnfwgpzqnfabpwucygbl35wyq 360 30 review review NN work_wtnfwgpzqnfabpwucygbl35wyq 360 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 361 1 Pediatr Pediatr NNP work_wtnfwgpzqnfabpwucygbl35wyq 361 2 Neurol Neurol NNP work_wtnfwgpzqnfabpwucygbl35wyq 361 3 2013;48:152–8 2013;48:152–8 CD work_wtnfwgpzqnfabpwucygbl35wyq 361 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 362 1 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 362 2 Jeffery Jeffery NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 3 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 362 5 Sinha Sinha NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 6 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 362 8 Srihari Srihari NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 9 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 362 11 Kalimutho Kalimutho NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 12 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 362 14 Khanna Khanna NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 15 KK KK NNP work_wtnfwgpzqnfabpwucygbl35wyq 362 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 363 1 Beyond beyond IN work_wtnfwgpzqnfabpwucygbl35wyq 363 2 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 363 3 : : : work_wtnfwgpzqnfabpwucygbl35wyq 363 4 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 363 5 emerging emerge VBG work_wtnfwgpzqnfabpwucygbl35wyq 363 6 roles role NNS work_wtnfwgpzqnfabpwucygbl35wyq 363 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 363 8 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 363 9 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 363 10 tumorigenesis tumorigenesis NN work_wtnfwgpzqnfabpwucygbl35wyq 363 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 364 1 Oncogene oncogene NN work_wtnfwgpzqnfabpwucygbl35wyq 364 2 2016;35:683–90 2016;35:683–90 CD work_wtnfwgpzqnfabpwucygbl35wyq 364 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 365 1 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 365 2 Jeffery Jeffery NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 3 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 5 Neyt Neyt NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 6 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 8 Moore Moore NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 9 W W NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 11 Paterson Paterson NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 12 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 14 Bower Bower NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 15 NI NI NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 17 Chenevix Chenevix NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 365 19 Trench Trench NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 20 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 22 Verkade Verkade NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 23 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 25 Hogan Hogan NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 26 BM BM NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 365 28 Khanna Khanna NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 29 KK KK NNP work_wtnfwgpzqnfabpwucygbl35wyq 365 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 366 1 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 366 2 regulates regulate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 366 3 embryonic embryonic JJ work_wtnfwgpzqnfabpwucygbl35wyq 366 4 growth growth NN work_wtnfwgpzqnfabpwucygbl35wyq 366 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 366 6 development development NN work_wtnfwgpzqnfabpwucygbl35wyq 366 7 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 366 8 promoting promote VBG work_wtnfwgpzqnfabpwucygbl35wyq 366 9 Akt Akt NNP work_wtnfwgpzqnfabpwucygbl35wyq 366 10 stability stability NN work_wtnfwgpzqnfabpwucygbl35wyq 366 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 366 12 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 366 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 367 1 FASEB FASEB NNP work_wtnfwgpzqnfabpwucygbl35wyq 367 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 367 3 2015;29:1999–2009 2015;29:1999–2009 CD work_wtnfwgpzqnfabpwucygbl35wyq 367 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 368 1 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 368 2 Carr Carr NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 3 IM IM NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 5 Diggle Diggle NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 6 CP CP NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 8 Touqan Touqan NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 9 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 11 Anwar Anwar NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 12 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 14 Sheridan Sheridan NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 15 EG EG NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 17 Bonthron Bonthron NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 18 DT DT NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 20 Johnson Johnson NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 21 CA CA NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 23 Ali Ali NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 24 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 368 26 Markham Markham NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 27 AF AF NNP work_wtnfwgpzqnfabpwucygbl35wyq 368 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 369 1 Identification identification NN work_wtnfwgpzqnfabpwucygbl35wyq 369 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 369 3 autosomal autosomal JJ work_wtnfwgpzqnfabpwucygbl35wyq 369 4 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 369 5 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 369 6 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 369 7 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 369 8 out out RB work_wtnfwgpzqnfabpwucygbl35wyq 369 9 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 369 10 bred breed VBN work_wtnfwgpzqnfabpwucygbl35wyq 369 11 nuclear nuclear JJ work_wtnfwgpzqnfabpwucygbl35wyq 369 12 families family NNS work_wtnfwgpzqnfabpwucygbl35wyq 369 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 370 1 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 370 2 Mutat Mutat NNP work_wtnfwgpzqnfabpwucygbl35wyq 370 3 2012;33:338–42 2012;33:338–42 CD work_wtnfwgpzqnfabpwucygbl35wyq 370 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 371 1 8 8 CD work_wtnfwgpzqnfabpwucygbl35wyq 371 2 Carr Carr NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 3 IM IM NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 371 5 Flintoff Flintoff NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 6 KJ KJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 371 8 Taylor Taylor NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 9 GR GR NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 371 11 Markham Markham NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 12 AF AF NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 371 14 Bonthron Bonthron NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 15 DT DT NNP work_wtnfwgpzqnfabpwucygbl35wyq 371 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 372 1 Interactive interactive JJ work_wtnfwgpzqnfabpwucygbl35wyq 372 2 visual visual JJ work_wtnfwgpzqnfabpwucygbl35wyq 372 3 analysis analysis NN work_wtnfwgpzqnfabpwucygbl35wyq 372 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 372 5 SNP SNP NNP work_wtnfwgpzqnfabpwucygbl35wyq 372 6 data datum NNS work_wtnfwgpzqnfabpwucygbl35wyq 372 7 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 372 8 rapid rapid JJ work_wtnfwgpzqnfabpwucygbl35wyq 372 9 autozygosity autozygosity NN work_wtnfwgpzqnfabpwucygbl35wyq 372 10 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 372 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 372 12 consanguineous consanguineous JJ work_wtnfwgpzqnfabpwucygbl35wyq 372 13 families family NNS work_wtnfwgpzqnfabpwucygbl35wyq 372 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 373 1 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 373 2 Mutat Mutat NNP work_wtnfwgpzqnfabpwucygbl35wyq 373 3 2006;27:1041–6 2006;27:1041–6 CD work_wtnfwgpzqnfabpwucygbl35wyq 373 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 374 1 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 374 2 Dyment Dyment NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 3 DA DA NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 5 Smith Smith NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 6 AC AC NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 8 Alcantara Alcantara NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 9 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 11 Schwartzentruber Schwartzentruber NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 12 JA JA NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 14 Basel Basel NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 374 16 Vanagaite Vanagaite NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 17 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 19 Curry Curry NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 20 CJ CJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 22 Temple Temple NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 23 IK IK NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 25 Reardon Reardon NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 26 W W NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 28 Mansour Mansour NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 29 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 31 Haq Haq NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 32 MR MR NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 34 Gilbert Gilbert NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 35 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 37 Lehmann Lehmann NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 38 OJ OJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 40 Vanstone Vanstone NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 41 MR MR NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 42 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 43 Beaulieu Beaulieu NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 44 CL CL NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 46 FORGE FORGE NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 47 Canada Canada NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 48 Consortium Consortium NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 49 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 50 Majewski Majewski NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 51 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 52 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 53 Bulman Bulman NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 54 DE DE NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 55 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 56 O’Driscoll O’Driscoll NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 57 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 58 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 59 Boycott Boycott NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 60 KM KM NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 61 , , , work_wtnfwgpzqnfabpwucygbl35wyq 374 62 Innes Innes NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 63 AM AM NNP work_wtnfwgpzqnfabpwucygbl35wyq 374 64 . . . work_wtnfwgpzqnfabpwucygbl35wyq 375 1 Mutations mutation NNS work_wtnfwgpzqnfabpwucygbl35wyq 375 2 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 375 3 PIK3R1 pik3r1 CD work_wtnfwgpzqnfabpwucygbl35wyq 375 4 cause cause VB work_wtnfwgpzqnfabpwucygbl35wyq 375 5 SHORT short JJ work_wtnfwgpzqnfabpwucygbl35wyq 375 6 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 375 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 376 1 Am be VBP work_wtnfwgpzqnfabpwucygbl35wyq 376 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 376 3 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 376 4 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 376 5 2013;93:158–66 2013;93:158–66 NNP work_wtnfwgpzqnfabpwucygbl35wyq 376 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 377 1 10 10 CD work_wtnfwgpzqnfabpwucygbl35wyq 377 2 Kague kague NN work_wtnfwgpzqnfabpwucygbl35wyq 377 3 E e NN work_wtnfwgpzqnfabpwucygbl35wyq 377 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 377 5 Gallagher Gallagher NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 6 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 377 8 Burke Burke NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 9 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 377 11 Parsons Parsons NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 12 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 377 14 Franz Franz NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 15 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 377 16 Odendaal Odendaal NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 17 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 18 , , , work_wtnfwgpzqnfabpwucygbl35wyq 377 19 Fisher Fisher NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 20 S. S. NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 21 Skeletogenic Skeletogenic NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 22 fate fate NN work_wtnfwgpzqnfabpwucygbl35wyq 377 23 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 377 24 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 25 cranial cranial JJ work_wtnfwgpzqnfabpwucygbl35wyq 377 26 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 377 27 trunk trunk NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 28 neural neural NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 29 crest crest NNP work_wtnfwgpzqnfabpwucygbl35wyq 377 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 378 1 PLoS PLoS : work_wtnfwgpzqnfabpwucygbl35wyq 378 2 ONE one CD work_wtnfwgpzqnfabpwucygbl35wyq 378 3 2012;7 2012;7 CD work_wtnfwgpzqnfabpwucygbl35wyq 378 4 : : : work_wtnfwgpzqnfabpwucygbl35wyq 378 5 e47394 e47394 NN work_wtnfwgpzqnfabpwucygbl35wyq 378 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 379 1 11 11 CD work_wtnfwgpzqnfabpwucygbl35wyq 379 2 Montague Montague NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 3 TG TG NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 379 5 Cruz Cruz NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 6 JM JM NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 379 8 Gagnon Gagnon NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 9 JA JA NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 379 11 Church Church NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 12 GM GM NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 379 14 Valen Valen NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 15 E. E. NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 16 CHOPCHOP CHOPCHOP NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 17 : : : work_wtnfwgpzqnfabpwucygbl35wyq 379 18 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 379 19 CRISPR/ CRISPR/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 20 Cas9 Cas9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 379 22 TALEN TALEN NNP work_wtnfwgpzqnfabpwucygbl35wyq 379 23 web web NN work_wtnfwgpzqnfabpwucygbl35wyq 379 24 tool tool NN work_wtnfwgpzqnfabpwucygbl35wyq 379 25 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 379 26 genome genome JJ work_wtnfwgpzqnfabpwucygbl35wyq 379 27 editing editing NN work_wtnfwgpzqnfabpwucygbl35wyq 379 28 . . . work_wtnfwgpzqnfabpwucygbl35wyq 380 1 Nucleic Nucleic NNP work_wtnfwgpzqnfabpwucygbl35wyq 380 2 Acids Acids NNPS work_wtnfwgpzqnfabpwucygbl35wyq 380 3 Res res NN work_wtnfwgpzqnfabpwucygbl35wyq 380 4 2014;42(Web 2014;42(Web NNP work_wtnfwgpzqnfabpwucygbl35wyq 380 5 Server Server NNP work_wtnfwgpzqnfabpwucygbl35wyq 380 6 issue):W401–7 issue):W401–7 NNP work_wtnfwgpzqnfabpwucygbl35wyq 380 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 381 1 12 12 CD work_wtnfwgpzqnfabpwucygbl35wyq 381 2 Jao Jao NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 3 LE LE NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 381 5 Wente Wente NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 6 SR SR NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 381 8 Chen Chen NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 9 W. W. NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 10 Efficient Efficient NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 11 multiplex multiplex VBD work_wtnfwgpzqnfabpwucygbl35wyq 381 12 biallelic biallelic JJ work_wtnfwgpzqnfabpwucygbl35wyq 381 13 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 14 genome genome NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 15 editing editing NN work_wtnfwgpzqnfabpwucygbl35wyq 381 16 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 381 17 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 381 18 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 381 19 nuclease nuclease NN work_wtnfwgpzqnfabpwucygbl35wyq 381 20 system system NN work_wtnfwgpzqnfabpwucygbl35wyq 381 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 382 1 Proc Proc NNP work_wtnfwgpzqnfabpwucygbl35wyq 382 2 Natl Natl NNP work_wtnfwgpzqnfabpwucygbl35wyq 382 3 Acad Acad NNP work_wtnfwgpzqnfabpwucygbl35wyq 382 4 Sci Sci NNP work_wtnfwgpzqnfabpwucygbl35wyq 382 5 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 382 6 2013;110:13904–9 2013;110:13904–9 CD work_wtnfwgpzqnfabpwucygbl35wyq 382 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 383 1 13 13 CD work_wtnfwgpzqnfabpwucygbl35wyq 383 2 Chen Chen NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 3 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 383 5 Khaleel Khaleel NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 6 SS SS NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 383 8 Huang Huang NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 9 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 383 11 Wu Wu NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 12 CH CH NNP work_wtnfwgpzqnfabpwucygbl35wyq 383 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 384 1 Software software NN work_wtnfwgpzqnfabpwucygbl35wyq 384 2 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 384 3 pre pre JJ work_wtnfwgpzqnfabpwucygbl35wyq 384 4 - - JJ work_wtnfwgpzqnfabpwucygbl35wyq 384 5 processing process VBG work_wtnfwgpzqnfabpwucygbl35wyq 384 6 Illumina Illumina NNP work_wtnfwgpzqnfabpwucygbl35wyq 384 7 next next JJ work_wtnfwgpzqnfabpwucygbl35wyq 384 8 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 384 9 generation generation NN work_wtnfwgpzqnfabpwucygbl35wyq 384 10 sequencing sequence VBG work_wtnfwgpzqnfabpwucygbl35wyq 384 11 short short JJ work_wtnfwgpzqnfabpwucygbl35wyq 384 12 read read NN work_wtnfwgpzqnfabpwucygbl35wyq 384 13 sequences sequence NNS work_wtnfwgpzqnfabpwucygbl35wyq 384 14 . . . work_wtnfwgpzqnfabpwucygbl35wyq 385 1 Source source NN work_wtnfwgpzqnfabpwucygbl35wyq 385 2 Code Code NNP work_wtnfwgpzqnfabpwucygbl35wyq 385 3 Biol Biol NNP work_wtnfwgpzqnfabpwucygbl35wyq 385 4 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 385 5 2014;9:8 2014;9:8 CD work_wtnfwgpzqnfabpwucygbl35wyq 385 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 385 7 eCollection ecollection NN work_wtnfwgpzqnfabpwucygbl35wyq 385 8 2014 2014 CD work_wtnfwgpzqnfabpwucygbl35wyq 385 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 386 1 14 14 CD work_wtnfwgpzqnfabpwucygbl35wyq 386 2 Pinello Pinello NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 3 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 386 5 Canver Canver NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 6 MC MC NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 386 8 Hoban Hoban NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 9 MD MD NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 386 11 Orkin Orkin NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 12 SH SH NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 386 14 Kohn Kohn NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 15 DB DB NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 386 17 Bauer Bauer NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 18 DE DE NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 386 20 Yuan Yuan NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 21 GC GC NNP work_wtnfwgpzqnfabpwucygbl35wyq 386 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 387 1 Analyzing analyze VBG work_wtnfwgpzqnfabpwucygbl35wyq 387 2 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 387 3 genome genome NN work_wtnfwgpzqnfabpwucygbl35wyq 387 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 387 5 editing edit VBG work_wtnfwgpzqnfabpwucygbl35wyq 387 6 experiments experiment NNS work_wtnfwgpzqnfabpwucygbl35wyq 387 7 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 387 8 CRISPResso crispresso NN work_wtnfwgpzqnfabpwucygbl35wyq 387 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 388 1 Nat Nat NNP work_wtnfwgpzqnfabpwucygbl35wyq 388 2 Biotechnol Biotechnol NNP work_wtnfwgpzqnfabpwucygbl35wyq 388 3 2016;34:695–7 2016;34:695–7 CD work_wtnfwgpzqnfabpwucygbl35wyq 388 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 389 1 15 15 CD work_wtnfwgpzqnfabpwucygbl35wyq 389 2 Isrie Isrie NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 3 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 5 Breuss Breuss NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 6 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 8 Tian Tian NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 9 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 11 Hansen Hansen NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 12 AH AH NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 14 Cristofoli Cristofoli NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 15 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 17 Morandell Morandell NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 18 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 20 Kupchinsky Kupchinsky NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 21 ZA ZA NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 23 Sifrim Sifrim NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 24 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 26 Rodriguez Rodriguez NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 27 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 389 28 Rodriguez Rodriguez NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 29 CM CM NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 31 Dapena Dapena NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 32 EP EP NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 34 Doonanco Doonanco NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 35 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 37 Leonard Leonard NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 38 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 40 Tinsa Tinsa NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 41 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 42 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 43 Moortgat Moortgat NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 44 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 46 Ulucan Ulucan NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 47 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 48 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 49 Koparir Koparir NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 50 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 51 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 52 Karaca Karaca NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 53 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 54 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 55 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 56 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 57 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 58 Marton Marton NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 59 V V NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 60 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 61 Vermeesch Vermeesch NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 62 JR JR NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 63 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 64 Davis Davis NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 65 EE EE NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 66 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 67 Cowan Cowan NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 68 NJ NJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 69 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 70 Keays Keays NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 71 DA DA NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 72 , , , work_wtnfwgpzqnfabpwucygbl35wyq 389 73 Van Van NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 74 Esch Esch NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 75 H. H. NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 76 Mutations Mutations NNPS work_wtnfwgpzqnfabpwucygbl35wyq 389 77 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 389 78 Either either CC work_wtnfwgpzqnfabpwucygbl35wyq 389 79 TUBB tubb NN work_wtnfwgpzqnfabpwucygbl35wyq 389 80 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 389 81 MAPRE2 mapre2 NN work_wtnfwgpzqnfabpwucygbl35wyq 389 82 Cause cause IN work_wtnfwgpzqnfabpwucygbl35wyq 389 83 Circumferential circumferential JJ work_wtnfwgpzqnfabpwucygbl35wyq 389 84 Skin skin NN work_wtnfwgpzqnfabpwucygbl35wyq 389 85 Creases crease NNS work_wtnfwgpzqnfabpwucygbl35wyq 389 86 Kunze Kunze NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 87 Type Type NNP work_wtnfwgpzqnfabpwucygbl35wyq 389 88 . . . work_wtnfwgpzqnfabpwucygbl35wyq 390 1 Am be VBP work_wtnfwgpzqnfabpwucygbl35wyq 390 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 390 3 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 390 4 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 390 5 2015;97:790–800 2015;97:790–800 CD work_wtnfwgpzqnfabpwucygbl35wyq 390 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 391 1 16 16 CD work_wtnfwgpzqnfabpwucygbl35wyq 391 2 Golzio Golzio NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 3 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 5 Willer Willer NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 6 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 8 Talkowski Talkowski NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 9 ME ME NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 11 Oh oh UH work_wtnfwgpzqnfabpwucygbl35wyq 391 12 EC EC NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 14 Taniguchi Taniguchi NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 15 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 17 Jacquemont Jacquemont NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 18 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 20 Reymond Reymond NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 21 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 23 Sun Sun NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 24 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 26 Sawa Sawa NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 27 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 29 Gusella Gusella NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 30 JF JF NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 32 Kamiya Kamiya NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 33 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 35 Beckmann Beckmann NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 36 JS JS NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 391 38 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 39 N. N. NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 40 KCTD13 KCTD13 NNP work_wtnfwgpzqnfabpwucygbl35wyq 391 41 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 391 42 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 391 43 major major JJ work_wtnfwgpzqnfabpwucygbl35wyq 391 44 driver driver NN work_wtnfwgpzqnfabpwucygbl35wyq 391 45 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 391 46 mirrored mirror VBN work_wtnfwgpzqnfabpwucygbl35wyq 391 47 neuroanatomical neuroanatomical JJ work_wtnfwgpzqnfabpwucygbl35wyq 391 48 phenotypes phenotype NNS work_wtnfwgpzqnfabpwucygbl35wyq 391 49 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 391 50 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 391 51 16p11.2 16p11.2 NNS work_wtnfwgpzqnfabpwucygbl35wyq 391 52 copy copy NN work_wtnfwgpzqnfabpwucygbl35wyq 391 53 number number NN work_wtnfwgpzqnfabpwucygbl35wyq 391 54 variant variant JJ work_wtnfwgpzqnfabpwucygbl35wyq 391 55 . . . work_wtnfwgpzqnfabpwucygbl35wyq 392 1 Nature nature NN work_wtnfwgpzqnfabpwucygbl35wyq 392 2 2012;485:363–7 2012;485:363–7 CD work_wtnfwgpzqnfabpwucygbl35wyq 392 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 393 1 500 500 CD work_wtnfwgpzqnfabpwucygbl35wyq 393 2 Frosk Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 393 3   _SP work_wtnfwgpzqnfabpwucygbl35wyq 393 4 P p NN work_wtnfwgpzqnfabpwucygbl35wyq 393 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 393 6 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 393 7   _SP work_wtnfwgpzqnfabpwucygbl35wyq 393 8 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 393 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 394 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 394 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 394 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 394 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 394 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 395 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 395 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 395 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 395 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 395 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 395 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 395 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 395 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 395 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 395 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 395 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 395 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 395 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 395 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 395 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 395 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 395 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 395 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 395 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 395 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 395 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 395 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 395 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 395 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 395 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 395 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 395 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 395 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 395 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 396 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 396 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 396 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 9 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 12 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 13 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 14 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 15 http://dx.doi.org/10.1016/j.pediatrneurol.2012.10.009 http://dx.doi.org/10.1016/j.pediatrneurol.2012.10.009 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 16 http://dx.doi.org/10.1038/onc.2015.128 http://dx.doi.org/10.1038/onc.2015.128 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 17 http://dx.doi.org/10.1096/fj.14-265090 http://dx.doi.org/10.1096/fj.14-265090 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 18 http://dx.doi.org/10.1002/humu.21645 http://dx.doi.org/10.1002/humu.21645 NN work_wtnfwgpzqnfabpwucygbl35wyq 396 19 http://dx.doi.org/10.1002/humu.20383 http://dx.doi.org/10.1002/humu.20383 -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 396 20 http://dx.doi.org/10.1016/j.ajhg.2013.06.005 http://dx.doi.org/10.1016/j.ajhg.2013.06.005 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 21 http://dx.doi.org/10.1016/j.ajhg.2013.06.005 http://dx.doi.org/10.1016/j.ajhg.2013.06.005 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 22 http://dx.doi.org/10.1371/journal.pone.0047394 http://dx.doi.org/10.1371/journal.pone.0047394 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 23 http://dx.doi.org/10.1093/nar/gku410 http://dx.doi.org/10.1093/nar/gku410 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 24 http://dx.doi.org/10.1073/pnas.1308335110 http://dx.doi.org/10.1073/pnas.1308335110 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 25 http://dx.doi.org/10.1186/1751-0473-9-8 http://dx.doi.org/10.1186/1751-0473-9-8 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 26 http://dx.doi.org/10.1038/nbt.3583 http://dx.doi.org/10.1038/nbt.3583 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 27 http://dx.doi.org/10.1016/j.ajhg.2015.10.014 http://dx.doi.org/10.1016/j.ajhg.2015.10.014 VBZ work_wtnfwgpzqnfabpwucygbl35wyq 396 28 http://dx.doi.org/10.1038/nature11091 http://dx.doi.org/10.1038/nature11091 NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 29 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 30 17 17 CD work_wtnfwgpzqnfabpwucygbl35wyq 396 31 Brooks Brooks NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 32 SS SS NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 34 Wall Wall NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 35 AL AL NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 37 Golzio Golzio NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 38 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 40 Reid Reid NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 41 DW DW NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 42 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 43 Kondyles Kondyles NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 44 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 46 Willer Willer NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 47 JR JR NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 48 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 49 Botti Botti NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 50 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 51 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 52 Nicchitta Nicchitta NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 53 CV CV NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 54 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 55 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 56 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 57 , , , work_wtnfwgpzqnfabpwucygbl35wyq 396 58 Davis Davis NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 59 EE EE NNP work_wtnfwgpzqnfabpwucygbl35wyq 396 60 . . . work_wtnfwgpzqnfabpwucygbl35wyq 397 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 397 2 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 397 3 ribosomopathy ribosomopathy NN work_wtnfwgpzqnfabpwucygbl35wyq 397 4 caused cause VBN work_wtnfwgpzqnfabpwucygbl35wyq 397 5 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 397 6 dysfunction dysfunction NN work_wtnfwgpzqnfabpwucygbl35wyq 397 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 397 8 RPL10 RPL10 NNP work_wtnfwgpzqnfabpwucygbl35wyq 397 9 disrupts disrupt NNS work_wtnfwgpzqnfabpwucygbl35wyq 397 10 neurodevelopment neurodevelopment JJ work_wtnfwgpzqnfabpwucygbl35wyq 397 11 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 397 12 causes cause VBZ work_wtnfwgpzqnfabpwucygbl35wyq 397 13 X X NNP work_wtnfwgpzqnfabpwucygbl35wyq 397 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 397 15 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 397 16 microcephaly microcephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 397 17 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 397 18 humans human NNS work_wtnfwgpzqnfabpwucygbl35wyq 397 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 398 1 Genetics Genetics NNP work_wtnfwgpzqnfabpwucygbl35wyq 398 2 2014;198:723–33 2014;198:723–33 CD work_wtnfwgpzqnfabpwucygbl35wyq 398 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 399 1 18 18 CD work_wtnfwgpzqnfabpwucygbl35wyq 399 2 Drummond Drummond NNP work_wtnfwgpzqnfabpwucygbl35wyq 399 3 IA IA NNP work_wtnfwgpzqnfabpwucygbl35wyq 399 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 399 5 Davidson Davidson NNP work_wtnfwgpzqnfabpwucygbl35wyq 399 6 AJ AJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 399 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 400 1 Zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 400 2 kidney kidney NN work_wtnfwgpzqnfabpwucygbl35wyq 400 3 development development NN work_wtnfwgpzqnfabpwucygbl35wyq 400 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 401 1 Methods Methods NNP work_wtnfwgpzqnfabpwucygbl35wyq 401 2 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 401 3 Biol Biol NNP work_wtnfwgpzqnfabpwucygbl35wyq 401 4 2010;100:233–60 2010;100:233–60 CD work_wtnfwgpzqnfabpwucygbl35wyq 401 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 402 1 19 19 CD work_wtnfwgpzqnfabpwucygbl35wyq 402 2 Lindstrand Lindstrand NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 3 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 5 Davis Davis NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 6 EE EE NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 8 Carvalho Carvalho NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 9 CM CM NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 11 Pehlivan Pehlivan NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 12 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 14 Willer Willer NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 15 JR JR NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 17 Tsai Tsai NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 18 IC IC NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 20 Ramanathan Ramanathan NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 21 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 23 Zuppan Zuppan NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 24 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 26 Sabo Sabo NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 27 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 29 Muzny Muzny NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 30 D d NN work_wtnfwgpzqnfabpwucygbl35wyq 402 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 32 Gibbs Gibbs NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 33 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 35 Liu Liu NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 36 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 38 Lewis Lewis NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 39 RA RA NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 41 Banin Banin NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 42 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 43 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 44 Lupski Lupski NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 45 JR JR NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 46 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 47 Clark Clark NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 48 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 49 , , , work_wtnfwgpzqnfabpwucygbl35wyq 402 50 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 51 N. N. NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 52 Recurrent Recurrent NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 53 CNVs CNVs NNPS work_wtnfwgpzqnfabpwucygbl35wyq 402 54 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 402 55 SNVs SNVs NNPS work_wtnfwgpzqnfabpwucygbl35wyq 402 56 at at IN work_wtnfwgpzqnfabpwucygbl35wyq 402 57 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 402 58 NPHP1 NPHP1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 59 locus locus NN work_wtnfwgpzqnfabpwucygbl35wyq 402 60 contribute contribute VBP work_wtnfwgpzqnfabpwucygbl35wyq 402 61 pathogenic pathogenic JJ work_wtnfwgpzqnfabpwucygbl35wyq 402 62 alleles allele NNS work_wtnfwgpzqnfabpwucygbl35wyq 402 63 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 402 64 Bardet Bardet NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 65 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 402 66 Biedl Biedl NNP work_wtnfwgpzqnfabpwucygbl35wyq 402 67 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 402 68 . . . work_wtnfwgpzqnfabpwucygbl35wyq 403 1 Am be VBP work_wtnfwgpzqnfabpwucygbl35wyq 403 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 403 3 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 403 4 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 403 5 2014;94:745–54 2014;94:745–54 NNP work_wtnfwgpzqnfabpwucygbl35wyq 403 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 404 1 20 20 CD work_wtnfwgpzqnfabpwucygbl35wyq 404 2 Niederriter niederriter NN work_wtnfwgpzqnfabpwucygbl35wyq 404 3 AR AR NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 404 5 Davis Davis NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 6 EE EE NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 404 8 Golzio Golzio NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 9 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 404 11 Oh oh UH work_wtnfwgpzqnfabpwucygbl35wyq 404 12 EC EC NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 404 14 Tsai Tsai NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 15 IC IC NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 404 17 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 18 N. N. NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 19 In in IN work_wtnfwgpzqnfabpwucygbl35wyq 404 20 vivo vivo NN work_wtnfwgpzqnfabpwucygbl35wyq 404 21 modeling modeling NN work_wtnfwgpzqnfabpwucygbl35wyq 404 22 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 404 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 404 24 morbid morbid NN work_wtnfwgpzqnfabpwucygbl35wyq 404 25 human human NN work_wtnfwgpzqnfabpwucygbl35wyq 404 26 genome genome NN work_wtnfwgpzqnfabpwucygbl35wyq 404 27 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 404 28 Danio Danio NNP work_wtnfwgpzqnfabpwucygbl35wyq 404 29 rerio rerio NN work_wtnfwgpzqnfabpwucygbl35wyq 404 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 405 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 405 2 Vis Vis NNP work_wtnfwgpzqnfabpwucygbl35wyq 405 3 Exp Exp NNP work_wtnfwgpzqnfabpwucygbl35wyq 405 4 2013;(78):e50338 2013;(78):e50338 CD work_wtnfwgpzqnfabpwucygbl35wyq 405 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 406 1 21 21 CD work_wtnfwgpzqnfabpwucygbl35wyq 406 2 Roepman Roepman NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 3 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 5 Letteboer Letteboer NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 6 SJ SJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 8 Arts Arts NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 9 HH HH NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 11 van van NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 12 Beersum Beersum NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 13 SE SE NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 15 Lu Lu NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 16 X X NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 18 Krieger Krieger NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 19 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 21 Ferreira Ferreira NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 22 PA PA NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 23 , , , work_wtnfwgpzqnfabpwucygbl35wyq 406 24 Cremers Cremers NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 25 FP FP NNP work_wtnfwgpzqnfabpwucygbl35wyq 406 26 . . . work_wtnfwgpzqnfabpwucygbl35wyq 407 1 Interaction Interaction NNP work_wtnfwgpzqnfabpwucygbl35wyq 407 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 407 3 nephrocystin-4 nephrocystin-4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 407 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 407 5 RPGRIP1 RPGRIP1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 407 6 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 407 7 disrupted disrupt VBN work_wtnfwgpzqnfabpwucygbl35wyq 407 8 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 407 9 nephronophthisis nephronophthisis NN work_wtnfwgpzqnfabpwucygbl35wyq 407 10 or or CC work_wtnfwgpzqnfabpwucygbl35wyq 407 11 Leber Leber NNP work_wtnfwgpzqnfabpwucygbl35wyq 407 12 congenital congenital JJ work_wtnfwgpzqnfabpwucygbl35wyq 407 13 amaurosis amaurosis NN work_wtnfwgpzqnfabpwucygbl35wyq 407 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 407 15 associated associate VBN work_wtnfwgpzqnfabpwucygbl35wyq 407 16 mutations mutation NNS work_wtnfwgpzqnfabpwucygbl35wyq 407 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 408 1 Proc Proc NNP work_wtnfwgpzqnfabpwucygbl35wyq 408 2 Natl Natl NNP work_wtnfwgpzqnfabpwucygbl35wyq 408 3 Acad Acad NNP work_wtnfwgpzqnfabpwucygbl35wyq 408 4 Sci Sci NNP work_wtnfwgpzqnfabpwucygbl35wyq 408 5 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 408 6 2005;102:18520–5 2005;102:18520–5 CD work_wtnfwgpzqnfabpwucygbl35wyq 408 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 409 1 22 22 CD work_wtnfwgpzqnfabpwucygbl35wyq 409 2 Lahiry Lahiry NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 3 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 409 5 Lee Lee NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 6 LJ LJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 409 8 Frey Frey NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 9 BJ BJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 409 11 Rupar Rupar NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 12 CA CA NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 409 14 Siu Siu NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 15 VM VM NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 409 17 Blencowe Blencowe NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 18 BJ BJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 409 20 Hegele Hegele NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 21 RA RA NNP work_wtnfwgpzqnfabpwucygbl35wyq 409 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 410 1 Transcriptional transcriptional JJ work_wtnfwgpzqnfabpwucygbl35wyq 410 2 profiling profiling NN work_wtnfwgpzqnfabpwucygbl35wyq 410 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 410 4 endocrine endocrine NN work_wtnfwgpzqnfabpwucygbl35wyq 410 5 cerebro cerebro NNP work_wtnfwgpzqnfabpwucygbl35wyq 410 6 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 410 7 osteodysplasia osteodysplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 410 8 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 410 9 microarray microarray JJ work_wtnfwgpzqnfabpwucygbl35wyq 410 10 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 410 11 next next JJ work_wtnfwgpzqnfabpwucygbl35wyq 410 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 410 13 generation generation NN work_wtnfwgpzqnfabpwucygbl35wyq 410 14 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 410 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 411 1 PLoS PLoS NNP work_wtnfwgpzqnfabpwucygbl35wyq 411 2 ONE one CD work_wtnfwgpzqnfabpwucygbl35wyq 411 3 2011;6 2011;6 CD work_wtnfwgpzqnfabpwucygbl35wyq 411 4 : : : work_wtnfwgpzqnfabpwucygbl35wyq 411 5 e25400 e25400 NNP work_wtnfwgpzqnfabpwucygbl35wyq 411 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 412 1 23 23 CD work_wtnfwgpzqnfabpwucygbl35wyq 412 2 Harding Harding NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 3 BN BN NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 5 Moccia Moccia NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 6 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 8 Drunat Drunat NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 9 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 11 Soukarieh Soukarieh NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 12 O O NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 14 Tubeuf Tubeuf NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 15 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 17 Chitty Chitty NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 18 LS LS NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 20 Verloes Verloes NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 21 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 23 Gressens Gressens NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 24 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 26 El El NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 27 Ghouzzi Ghouzzi NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 28 V V NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 29 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 30 Joriot Joriot NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 31 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 32 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 33 Di Di NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 34 Cunto Cunto NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 35 F F NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 37 Martins Martins NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 38 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 40 Passemard Passemard NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 41 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 42 , , , work_wtnfwgpzqnfabpwucygbl35wyq 412 43 Bielas Bielas NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 44 SL SL NNP work_wtnfwgpzqnfabpwucygbl35wyq 412 45 . . . work_wtnfwgpzqnfabpwucygbl35wyq 413 1 Mutations mutation NNS work_wtnfwgpzqnfabpwucygbl35wyq 413 2 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 413 3 citron citron NN work_wtnfwgpzqnfabpwucygbl35wyq 413 4 kinase kinase NNP work_wtnfwgpzqnfabpwucygbl35wyq 413 5 cause cause NNP work_wtnfwgpzqnfabpwucygbl35wyq 413 6 recessive recessive JJ work_wtnfwgpzqnfabpwucygbl35wyq 413 7 microlissencephaly microlissencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 413 8 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 413 9 multinucleated multinucleated JJ work_wtnfwgpzqnfabpwucygbl35wyq 413 10 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 413 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 414 1 Am be VBP work_wtnfwgpzqnfabpwucygbl35wyq 414 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 414 3 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 414 4 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 414 5 2016;99:511–20 2016;99:511–20 NNP work_wtnfwgpzqnfabpwucygbl35wyq 414 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 415 1 24 24 CD work_wtnfwgpzqnfabpwucygbl35wyq 415 2 Bendon Bendon NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 3 RW RW NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 415 5 Siddiqi Siddiqi NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 6 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 415 8 de de NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 9 Courten Courten NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 10 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 415 11 Myers Myers NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 12 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 415 14 Dignan Dignan NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 15 P. P. NNP work_wtnfwgpzqnfabpwucygbl35wyq 415 16 Recurrent recurrent JJ work_wtnfwgpzqnfabpwucygbl35wyq 415 17 developmental developmental JJ work_wtnfwgpzqnfabpwucygbl35wyq 415 18 anomalies anomaly NNS work_wtnfwgpzqnfabpwucygbl35wyq 415 19 : : : work_wtnfwgpzqnfabpwucygbl35wyq 415 20 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 415 21 . . . work_wtnfwgpzqnfabpwucygbl35wyq 416 1 Syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 416 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 416 3 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 416 4 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 416 5 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 416 6 aplastic aplastic NNP work_wtnfwgpzqnfabpwucygbl35wyq 416 7 dysplasia dysplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 416 8 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 416 9 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 416 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 417 1 Polyvalvular polyvalvular JJ work_wtnfwgpzqnfabpwucygbl35wyq 417 2 developmental developmental JJ work_wtnfwgpzqnfabpwucygbl35wyq 417 3 heart heart NN work_wtnfwgpzqnfabpwucygbl35wyq 417 4 defect defect NN work_wtnfwgpzqnfabpwucygbl35wyq 417 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 418 1 Am be VBP work_wtnfwgpzqnfabpwucygbl35wyq 418 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 418 3 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 418 4 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 418 5 Suppl Suppl NNP work_wtnfwgpzqnfabpwucygbl35wyq 418 6 1987;3:357–65 1987;3:357–65 CD work_wtnfwgpzqnfabpwucygbl35wyq 418 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 419 1 25 25 CD work_wtnfwgpzqnfabpwucygbl35wyq 419 2 Gschwendtner Gschwendtner NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 3 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 419 5 Mairinger Mairinger NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 6 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 419 8 Soelder Soelder NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 9 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 419 11 Alge Alge NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 12 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 419 14 Kreczy Kreczy NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 15 A. a. NN work_wtnfwgpzqnfabpwucygbl35wyq 419 16 Hydranencephaly Hydranencephaly NNP work_wtnfwgpzqnfabpwucygbl35wyq 419 17 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 419 18 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 419 19 dysgenesis dysgenesis NN work_wtnfwgpzqnfabpwucygbl35wyq 419 20 : : : work_wtnfwgpzqnfabpwucygbl35wyq 419 21 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 419 22 coincidental coincidental JJ work_wtnfwgpzqnfabpwucygbl35wyq 419 23 finding finding NN work_wtnfwgpzqnfabpwucygbl35wyq 419 24 ? ? . work_wtnfwgpzqnfabpwucygbl35wyq 420 1 Case case NN work_wtnfwgpzqnfabpwucygbl35wyq 420 2 report report VBP work_wtnfwgpzqnfabpwucygbl35wyq 420 3 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 420 4 review review NN work_wtnfwgpzqnfabpwucygbl35wyq 420 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 420 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 420 7 literature literature NN work_wtnfwgpzqnfabpwucygbl35wyq 420 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 421 1 Gynecol Gynecol NNP work_wtnfwgpzqnfabpwucygbl35wyq 421 2 Obstet Obstet NNP work_wtnfwgpzqnfabpwucygbl35wyq 421 3 Invest Invest NNP work_wtnfwgpzqnfabpwucygbl35wyq 421 4 1997;44:206–10 1997;44:206–10 NN work_wtnfwgpzqnfabpwucygbl35wyq 421 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 422 1 26 26 CD work_wtnfwgpzqnfabpwucygbl35wyq 422 2 Hamby Hamby NNP work_wtnfwgpzqnfabpwucygbl35wyq 422 3 WB WB NNP work_wtnfwgpzqnfabpwucygbl35wyq 422 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 422 5 Krauss Krauss NNP work_wtnfwgpzqnfabpwucygbl35wyq 422 6 RF RF NNP work_wtnfwgpzqnfabpwucygbl35wyq 422 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 422 8 Beswick Beswick NNP work_wtnfwgpzqnfabpwucygbl35wyq 422 9 WF WF NNP work_wtnfwgpzqnfabpwucygbl35wyq 422 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 423 1 Hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 423 2 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 423 3 clinical clinical JJ work_wtnfwgpzqnfabpwucygbl35wyq 423 4 diagnosis diagnosis NN work_wtnfwgpzqnfabpwucygbl35wyq 423 5 ; ; : work_wtnfwgpzqnfabpwucygbl35wyq 423 6 presentation presentation NN work_wtnfwgpzqnfabpwucygbl35wyq 423 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 423 8 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 423 9 cases case NNS work_wtnfwgpzqnfabpwucygbl35wyq 423 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 424 1 Pediatrics pediatric NNS work_wtnfwgpzqnfabpwucygbl35wyq 424 2 1950;6:371–83 1950;6:371–83 CD work_wtnfwgpzqnfabpwucygbl35wyq 424 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 425 1 27 27 CD work_wtnfwgpzqnfabpwucygbl35wyq 425 2 Strauss Strauss NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 3 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 425 5 Bouzouki Bouzouki NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 6 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 425 8 Goldfarb Goldfarb NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 9 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 425 11 Uppal Uppal NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 12 V V NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 425 14 Costales Costales NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 15 F. F. NNP work_wtnfwgpzqnfabpwucygbl35wyq 425 16 Antenatal antenatal JJ work_wtnfwgpzqnfabpwucygbl35wyq 425 17 ultrasound ultrasound JJ work_wtnfwgpzqnfabpwucygbl35wyq 425 18 diagnosis diagnosis NN work_wtnfwgpzqnfabpwucygbl35wyq 425 19 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 425 20 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 425 21 unusual unusual JJ work_wtnfwgpzqnfabpwucygbl35wyq 425 22 case case NN work_wtnfwgpzqnfabpwucygbl35wyq 425 23 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 425 24 hydranencephaly hydranencephaly NN work_wtnfwgpzqnfabpwucygbl35wyq 425 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 426 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 426 2 Clin Clin NNP work_wtnfwgpzqnfabpwucygbl35wyq 426 3 Ultrasound Ultrasound NNP work_wtnfwgpzqnfabpwucygbl35wyq 426 4 1984;12:420–2 1984;12:420–2 CD work_wtnfwgpzqnfabpwucygbl35wyq 426 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 427 1 28 28 CD work_wtnfwgpzqnfabpwucygbl35wyq 427 2 Chu Chu NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 3 GC GC NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 427 5 Miller Miller NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 6 WA WA NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 427 8 Norton Norton NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 9 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 427 11 Kinney Kinney NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 12 HC HC NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 427 14 Genest Genest NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 15 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 427 17 Folkerth Folkerth NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 18 RD RD NNP work_wtnfwgpzqnfabpwucygbl35wyq 427 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 428 1 Hydranencephaly hydranencephaly VB work_wtnfwgpzqnfabpwucygbl35wyq 428 2 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 428 3 binucleate binucleate JJ work_wtnfwgpzqnfabpwucygbl35wyq 428 4 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 428 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 428 6 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 428 7 dysplasia dysplasia NNP work_wtnfwgpzqnfabpwucygbl35wyq 428 8 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 428 9 syndactyly syndactyly NNP work_wtnfwgpzqnfabpwucygbl35wyq 428 10 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 428 11 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 428 12 three three CD work_wtnfwgpzqnfabpwucygbl35wyq 428 13 siblings sibling NNS work_wtnfwgpzqnfabpwucygbl35wyq 428 14 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 428 15 Abstract Abstract NNP work_wtnfwgpzqnfabpwucygbl35wyq 428 16 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 428 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 429 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 429 2 Neuropathol Neuropathol NNP work_wtnfwgpzqnfabpwucygbl35wyq 429 3 Exp Exp NNP work_wtnfwgpzqnfabpwucygbl35wyq 429 4 Neurol Neurol NNP work_wtnfwgpzqnfabpwucygbl35wyq 429 5 1998;54:483 1998;54:483 CD work_wtnfwgpzqnfabpwucygbl35wyq 429 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 430 1 29 29 CD work_wtnfwgpzqnfabpwucygbl35wyq 430 2 Orton Orton NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 3 NC NC NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 430 5 Innes Innes NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 6 AM AM NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 430 8 Chudley Chudley NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 9 AE AE NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 430 11 Bech Bech NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 12 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 430 13 Hansen Hansen NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 14 NT NT NNP work_wtnfwgpzqnfabpwucygbl35wyq 430 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 431 1 Unique unique JJ work_wtnfwgpzqnfabpwucygbl35wyq 431 2 disease disease NN work_wtnfwgpzqnfabpwucygbl35wyq 431 3 heritage heritage NN work_wtnfwgpzqnfabpwucygbl35wyq 431 4 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 431 5 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 431 6 Dutch dutch JJ work_wtnfwgpzqnfabpwucygbl35wyq 431 7 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 431 8 German german JJ work_wtnfwgpzqnfabpwucygbl35wyq 431 9 Mennonite Mennonite NNP work_wtnfwgpzqnfabpwucygbl35wyq 431 10 population population NN work_wtnfwgpzqnfabpwucygbl35wyq 431 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 432 1 Am be VBP work_wtnfwgpzqnfabpwucygbl35wyq 432 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 432 3 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 432 4 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 432 5 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 432 6 2008;146A:1072–87 2008;146a:1072–87 NN work_wtnfwgpzqnfabpwucygbl35wyq 432 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 433 1 http://dx.doi.org/10.1002/ajmg.a.32061 http://dx.doi.org/10.1002/ajmg.a.32061 NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 2 30 30 CD work_wtnfwgpzqnfabpwucygbl35wyq 433 3 Schweingruber Schweingruber NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 4 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 5 , , , work_wtnfwgpzqnfabpwucygbl35wyq 433 6 Rufener Rufener NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 7 SC SC NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 433 9 Zünd Zünd NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 10 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 433 12 Yamashita Yamashita NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 13 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 433 15 Muhlemann Muhlemann NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 16 O. O. NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 17 Nonsense Nonsense NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 433 19 mediated mediate VBN work_wtnfwgpzqnfabpwucygbl35wyq 433 20 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 21 decay decay NN work_wtnfwgpzqnfabpwucygbl35wyq 433 22 — — : work_wtnfwgpzqnfabpwucygbl35wyq 433 23 mechanisms mechanism NNS work_wtnfwgpzqnfabpwucygbl35wyq 433 24 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 433 25 substrate substrate NN work_wtnfwgpzqnfabpwucygbl35wyq 433 26 mRNA mRNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 433 27 recognition recognition NN work_wtnfwgpzqnfabpwucygbl35wyq 433 28 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 433 29 degradation degradation NN work_wtnfwgpzqnfabpwucygbl35wyq 433 30 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 433 31 mammalian mammalian JJ work_wtnfwgpzqnfabpwucygbl35wyq 433 32 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 433 33 . . . work_wtnfwgpzqnfabpwucygbl35wyq 434 1 Biochim Biochim NNP work_wtnfwgpzqnfabpwucygbl35wyq 434 2 Biophys Biophys NNP work_wtnfwgpzqnfabpwucygbl35wyq 434 3 Acta Acta NNP work_wtnfwgpzqnfabpwucygbl35wyq 434 4 2013;1829:612–23 2013;1829:612–23 NNP work_wtnfwgpzqnfabpwucygbl35wyq 434 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 435 1 31 31 CD work_wtnfwgpzqnfabpwucygbl35wyq 435 2 Fabbro Fabbro NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 3 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 5 Zhou Zhou NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 6 BB BB NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 8 Takahashi Takahashi NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 9 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 11 Sarcevic Sarcevic NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 12 B B NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 14 Lal Lal NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 15 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 17 Graham Graham NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 18 ME ME NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 20 Gabrielli Gabrielli NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 21 BG BG NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 23 Robinson Robinson NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 24 PJ PJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 26 Nigg Nigg NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 27 EA EA NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 29 Ono Ono NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 30 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 435 32 Khanna Khanna NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 33 KK KK NNP work_wtnfwgpzqnfabpwucygbl35wyq 435 34 . . . work_wtnfwgpzqnfabpwucygbl35wyq 436 1 Cdk1 cdk1 JJ work_wtnfwgpzqnfabpwucygbl35wyq 436 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 436 3 Erk2- Erk2- NNP work_wtnfwgpzqnfabpwucygbl35wyq 436 4 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 436 5 Plk1-dependent plk1-dependent JJ work_wtnfwgpzqnfabpwucygbl35wyq 436 6 phosphorylation phosphorylation NN work_wtnfwgpzqnfabpwucygbl35wyq 436 7 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 436 8 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 436 9 centrosome centrosome NN work_wtnfwgpzqnfabpwucygbl35wyq 436 10 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 436 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 436 12 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 436 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 436 14 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 436 15 required require VBN work_wtnfwgpzqnfabpwucygbl35wyq 436 16 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 436 17 its -PRON- PRP$ work_wtnfwgpzqnfabpwucygbl35wyq 436 18 recruitment recruitment NN work_wtnfwgpzqnfabpwucygbl35wyq 436 19 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 436 20 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 436 21 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 436 22 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 436 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 437 1 Dev Dev NNP work_wtnfwgpzqnfabpwucygbl35wyq 437 2 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 437 3 2005;9:477–88 2005;9:477–88 CD work_wtnfwgpzqnfabpwucygbl35wyq 437 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 438 1 32 32 CD work_wtnfwgpzqnfabpwucygbl35wyq 438 2 van van NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 3 der der XX work_wtnfwgpzqnfabpwucygbl35wyq 438 4 Horst Horst NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 5 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 438 7 Simmons Simmons NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 8 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 438 10 Khanna Khanna NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 11 KK KK NNP work_wtnfwgpzqnfabpwucygbl35wyq 438 12 . . . work_wtnfwgpzqnfabpwucygbl35wyq 439 1 Cep55 cep55 JJ work_wtnfwgpzqnfabpwucygbl35wyq 439 2 stabilization stabilization NN work_wtnfwgpzqnfabpwucygbl35wyq 439 3 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 439 4 required require VBN work_wtnfwgpzqnfabpwucygbl35wyq 439 5 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 439 6 normal normal JJ work_wtnfwgpzqnfabpwucygbl35wyq 439 7 execution execution NN work_wtnfwgpzqnfabpwucygbl35wyq 439 8 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 439 9 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 439 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 440 1 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 440 2 Cycle Cycle NNP work_wtnfwgpzqnfabpwucygbl35wyq 440 3 2009;8:3742–9 2009;8:3742–9 CD work_wtnfwgpzqnfabpwucygbl35wyq 440 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 441 1 33 33 CD work_wtnfwgpzqnfabpwucygbl35wyq 441 2 Kircher Kircher NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 3 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 441 5 Witten Witten NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 6 DM DM NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 441 8 Jain Jain NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 9 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 441 11 O’Roak O’Roak NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 12 BJ BJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 441 14 Cooper Cooper NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 15 GM GM NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 441 17 Shendure Shendure NNP work_wtnfwgpzqnfabpwucygbl35wyq 441 18 J. J. NNP work_wtnfwgpzqnfabpwucygbl35wyq 442 1 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 442 2 general general JJ work_wtnfwgpzqnfabpwucygbl35wyq 442 3 framework framework NN work_wtnfwgpzqnfabpwucygbl35wyq 442 4 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 442 5 estimating estimate VBG work_wtnfwgpzqnfabpwucygbl35wyq 442 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 442 7 relative relative JJ work_wtnfwgpzqnfabpwucygbl35wyq 442 8 pathogenicity pathogenicity NN work_wtnfwgpzqnfabpwucygbl35wyq 442 9 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 442 10 human human JJ work_wtnfwgpzqnfabpwucygbl35wyq 442 11 genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 442 12 variants variant NNS work_wtnfwgpzqnfabpwucygbl35wyq 442 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 443 1 Nat Nat NNP work_wtnfwgpzqnfabpwucygbl35wyq 443 2 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 443 3 2014;46:310–15 2014;46:310–15 NN work_wtnfwgpzqnfabpwucygbl35wyq 443 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 444 1 34 34 CD work_wtnfwgpzqnfabpwucygbl35wyq 444 2 Bastos Bastos NNP work_wtnfwgpzqnfabpwucygbl35wyq 444 3 RN RN NNP work_wtnfwgpzqnfabpwucygbl35wyq 444 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 444 5 Barr Barr NNP work_wtnfwgpzqnfabpwucygbl35wyq 444 6 FA FA NNP work_wtnfwgpzqnfabpwucygbl35wyq 444 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 445 1 Plk1 plk1 JJ work_wtnfwgpzqnfabpwucygbl35wyq 445 2 negatively negatively RB work_wtnfwgpzqnfabpwucygbl35wyq 445 3 regulates regulate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 445 4 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 445 5 recruitment recruitment NN work_wtnfwgpzqnfabpwucygbl35wyq 445 6 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 445 7 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 445 8 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 445 9 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 445 10 ensure ensure VB work_wtnfwgpzqnfabpwucygbl35wyq 445 11 orderly orderly JJ work_wtnfwgpzqnfabpwucygbl35wyq 445 12 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 445 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 446 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 446 2 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 446 3 Biol Biol NNP work_wtnfwgpzqnfabpwucygbl35wyq 446 4 2010;191:751–60 2010;191:751–60 CD work_wtnfwgpzqnfabpwucygbl35wyq 446 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 447 1 35 35 CD work_wtnfwgpzqnfabpwucygbl35wyq 447 2 Chang Chang NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 3 YC YC NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 447 5 Wu Wu NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 6 CH CH NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 447 8 Yen yen NN work_wtnfwgpzqnfabpwucygbl35wyq 447 9 TC TC NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 447 11 Ouyang Ouyang NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 12 P. P. NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 13 Centrosomal Centrosomal NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 14 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 447 15 55 55 CD work_wtnfwgpzqnfabpwucygbl35wyq 447 16 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 447 17 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 18 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 447 19 stability stability NN work_wtnfwgpzqnfabpwucygbl35wyq 447 20 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 447 21 negatively negatively RB work_wtnfwgpzqnfabpwucygbl35wyq 447 22 regulated regulate VBN work_wtnfwgpzqnfabpwucygbl35wyq 447 23 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 447 24 p53 p53 NN work_wtnfwgpzqnfabpwucygbl35wyq 447 25 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 447 26 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 447 27 Polo Polo NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 28 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 447 29 like like JJ work_wtnfwgpzqnfabpwucygbl35wyq 447 30 kinase kinase NN work_wtnfwgpzqnfabpwucygbl35wyq 447 31 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 447 32 ( ( -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 447 33 Plk1 Plk1 NNP work_wtnfwgpzqnfabpwucygbl35wyq 447 34 ) ) -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 447 35 . . . work_wtnfwgpzqnfabpwucygbl35wyq 448 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 448 2 Biol Biol NNP work_wtnfwgpzqnfabpwucygbl35wyq 448 3 Chem Chem NNP work_wtnfwgpzqnfabpwucygbl35wyq 448 4 2012;287:4376–85 2012;287:4376–85 NNP work_wtnfwgpzqnfabpwucygbl35wyq 448 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 449 1 36 36 CD work_wtnfwgpzqnfabpwucygbl35wyq 449 2 Inoda Inoda NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 3 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 5 Hirohashi Hirohashi NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 6 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 8 Torigoe Torigoe NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 9 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 11 Nakatsugawa Nakatsugawa NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 12 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 14 Kiriyama Kiriyama NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 15 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 17 Nakazawa Nakazawa NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 18 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 20 Harada Harada NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 21 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 23 Takasu Takasu NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 24 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 26 Tamura Tamura NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 27 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 29 Kamiguchi Kamiguchi NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 30 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 32 Asanuma Asanuma NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 33 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 35 Tsuruma Tsuruma NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 36 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 38 Terui Terui NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 39 T t NN work_wtnfwgpzqnfabpwucygbl35wyq 449 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 41 Ishitani Ishitani NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 42 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 43 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 44 Ohmura Ohmura NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 45 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 46 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 47 Wang Wang NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 48 Q Q NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 49 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 50 Greene Greene NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 51 MI MI NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 52 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 53 Hasegawa Hasegawa NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 54 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 55 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 56 Hirata Hirata NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 57 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 58 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 59 Sato Sato NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 60 N. N. NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 61 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 62 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 449 63 c10orf3 c10orf3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 449 64 , , , work_wtnfwgpzqnfabpwucygbl35wyq 449 65 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 449 66 tumor tumor NN work_wtnfwgpzqnfabpwucygbl35wyq 449 67 antigen antigen NN work_wtnfwgpzqnfabpwucygbl35wyq 449 68 derived derive VBN work_wtnfwgpzqnfabpwucygbl35wyq 449 69 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 449 70 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 449 71 centrosome centrosome NN work_wtnfwgpzqnfabpwucygbl35wyq 449 72 residing reside VBG work_wtnfwgpzqnfabpwucygbl35wyq 449 73 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 449 74 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 449 75 breast breast NN work_wtnfwgpzqnfabpwucygbl35wyq 449 76 carcinoma carcinoma NN work_wtnfwgpzqnfabpwucygbl35wyq 449 77 . . . work_wtnfwgpzqnfabpwucygbl35wyq 450 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 450 2 Immunother Immunother NNP work_wtnfwgpzqnfabpwucygbl35wyq 450 3 2009;32:474–85 2009;32:474–85 NNP work_wtnfwgpzqnfabpwucygbl35wyq 450 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 451 1 37 37 CD work_wtnfwgpzqnfabpwucygbl35wyq 451 2 Zhao Zhao NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 3 WM WM NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 451 5 Seki Seki NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 6 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 451 8 Fang Fang NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 9 G. G. NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 10 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 11 , , , work_wtnfwgpzqnfabpwucygbl35wyq 451 12 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 451 13 microtubule microtubule NN work_wtnfwgpzqnfabpwucygbl35wyq 451 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 451 15 bundling bundle VBG work_wtnfwgpzqnfabpwucygbl35wyq 451 16 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 451 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 451 18 associates associate NNS work_wtnfwgpzqnfabpwucygbl35wyq 451 19 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 451 20 centralspindlin centralspindlin NNP work_wtnfwgpzqnfabpwucygbl35wyq 451 21 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 451 22 control control VB work_wtnfwgpzqnfabpwucygbl35wyq 451 23 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 451 24 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 451 25 integrity integrity NN work_wtnfwgpzqnfabpwucygbl35wyq 451 26 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 451 27 cell cell NN work_wtnfwgpzqnfabpwucygbl35wyq 451 28 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 451 29 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 451 30 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 451 31 . . . work_wtnfwgpzqnfabpwucygbl35wyq 452 1 Mol Mol NNP work_wtnfwgpzqnfabpwucygbl35wyq 452 2 Biol Biol NNP work_wtnfwgpzqnfabpwucygbl35wyq 452 3 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 452 4 2006;17:3881–96 2006;17:3881–96 CD work_wtnfwgpzqnfabpwucygbl35wyq 452 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 453 1 38 38 CD work_wtnfwgpzqnfabpwucygbl35wyq 453 2 van van NNP work_wtnfwgpzqnfabpwucygbl35wyq 453 3 der der XX work_wtnfwgpzqnfabpwucygbl35wyq 453 4 Horst Horst NNP work_wtnfwgpzqnfabpwucygbl35wyq 453 5 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 453 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 453 7 Khanna Khanna NNP work_wtnfwgpzqnfabpwucygbl35wyq 453 8 KK KK NNP work_wtnfwgpzqnfabpwucygbl35wyq 453 9 . . . work_wtnfwgpzqnfabpwucygbl35wyq 454 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 454 2 peptidyl peptidyl NN work_wtnfwgpzqnfabpwucygbl35wyq 454 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 454 4 prolyl prolyl JJ work_wtnfwgpzqnfabpwucygbl35wyq 454 5 isomerase isomerase NN work_wtnfwgpzqnfabpwucygbl35wyq 454 6 Pin1 pin1 NN work_wtnfwgpzqnfabpwucygbl35wyq 454 7 regulates regulate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 454 8 cytokinesis cytokinesis NN work_wtnfwgpzqnfabpwucygbl35wyq 454 9 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 454 10 Cep55 Cep55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 454 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 455 1 Cancer cancer NN work_wtnfwgpzqnfabpwucygbl35wyq 455 2 Res Res NNP work_wtnfwgpzqnfabpwucygbl35wyq 455 3 2009;69:6651–9 2009;69:6651–9 CD work_wtnfwgpzqnfabpwucygbl35wyq 455 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 456 1 39 39 CD work_wtnfwgpzqnfabpwucygbl35wyq 456 2 BrainSpan BrainSpan NNP work_wtnfwgpzqnfabpwucygbl35wyq 456 3 : : : work_wtnfwgpzqnfabpwucygbl35wyq 456 4 Atlas Atlas NNP work_wtnfwgpzqnfabpwucygbl35wyq 456 5 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 456 6 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 456 7 Developing Developing NNP work_wtnfwgpzqnfabpwucygbl35wyq 456 8 Human Human NNP work_wtnfwgpzqnfabpwucygbl35wyq 456 9 Brain Brain NNP work_wtnfwgpzqnfabpwucygbl35wyq 456 10 [ [ -LRB- work_wtnfwgpzqnfabpwucygbl35wyq 456 11 Internet internet NN work_wtnfwgpzqnfabpwucygbl35wyq 456 12 ] ] -RRB- work_wtnfwgpzqnfabpwucygbl35wyq 456 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 457 1 Funded fund VBN work_wtnfwgpzqnfabpwucygbl35wyq 457 2 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 457 3 ARRA ARRA NNP work_wtnfwgpzqnfabpwucygbl35wyq 457 4 Awards Awards NNPS work_wtnfwgpzqnfabpwucygbl35wyq 457 5 1RC2MH089921 1rc2mh089921 CD work_wtnfwgpzqnfabpwucygbl35wyq 457 6 - - SYM work_wtnfwgpzqnfabpwucygbl35wyq 457 7 01 01 CD work_wtnfwgpzqnfabpwucygbl35wyq 457 8 , , , work_wtnfwgpzqnfabpwucygbl35wyq 457 9 1RC2MH090047 1rc2mh090047 CD work_wtnfwgpzqnfabpwucygbl35wyq 457 10 - - SYM work_wtnfwgpzqnfabpwucygbl35wyq 457 11 01 01 CD work_wtnfwgpzqnfabpwucygbl35wyq 457 12 , , , work_wtnfwgpzqnfabpwucygbl35wyq 457 13 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 457 14 1RC2MH089929 1rc2mh089929 CD work_wtnfwgpzqnfabpwucygbl35wyq 457 15 - - SYM work_wtnfwgpzqnfabpwucygbl35wyq 457 16 01 01 CD work_wtnfwgpzqnfabpwucygbl35wyq 457 17 . . . work_wtnfwgpzqnfabpwucygbl35wyq 458 1 2011 2011 CD work_wtnfwgpzqnfabpwucygbl35wyq 458 2 . . . work_wtnfwgpzqnfabpwucygbl35wyq 458 3 http://developinghumanbrain.org http://developinghumanbrain.org ADD work_wtnfwgpzqnfabpwucygbl35wyq 458 4 40 40 CD work_wtnfwgpzqnfabpwucygbl35wyq 458 5 Stiles Stiles NNPS work_wtnfwgpzqnfabpwucygbl35wyq 458 6 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 458 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 458 8 Jernigan Jernigan NNP work_wtnfwgpzqnfabpwucygbl35wyq 458 9 TL TL NNP work_wtnfwgpzqnfabpwucygbl35wyq 458 10 . . . work_wtnfwgpzqnfabpwucygbl35wyq 459 1 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 459 2 basics basic NNS work_wtnfwgpzqnfabpwucygbl35wyq 459 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 459 4 brain brain NN work_wtnfwgpzqnfabpwucygbl35wyq 459 5 development development NN work_wtnfwgpzqnfabpwucygbl35wyq 459 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 460 1 Neuropsychol Neuropsychol NNP work_wtnfwgpzqnfabpwucygbl35wyq 460 2 Rev Rev NNP work_wtnfwgpzqnfabpwucygbl35wyq 460 3 2010;20:327–48 2010;20:327–48 NNP work_wtnfwgpzqnfabpwucygbl35wyq 460 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 461 1 41 41 CD work_wtnfwgpzqnfabpwucygbl35wyq 461 2 Magini Magini NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 3 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 5 Pippucci Pippucci NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 6 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 8 Tsai Tsai NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 9 IC IC NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 11 Coppola Coppola NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 12 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 14 Stellacci Stellacci NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 15 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 17 Bartoletti Bartoletti NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 18 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 461 19 Stella Stella NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 20 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 21 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 22 Turchetti Turchetti NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 23 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 24 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 25 Graziano Graziano NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 26 C C NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 27 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 28 Cenacchi Cenacchi NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 29 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 30 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 31 Neri Neri NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 32 I I NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 33 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 34 Cordelli Cordelli NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 35 DM DM NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 36 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 37 Marchiani Marchiani NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 38 V V NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 39 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 40 Bergamaschi Bergamaschi NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 41 R R NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 42 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 43 Gasparre Gasparre NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 44 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 45 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 46 Neri Neri NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 47 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 48 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 49 Mazzanti Mazzanti NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 50 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 51 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 52 Patrizi Patrizi NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 53 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 54 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 55 Franzoni Franzoni NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 56 E E NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 57 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 58 Romeo Romeo NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 59 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 60 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 61 Bordo Bordo NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 62 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 63 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 64 Tartaglia Tartaglia NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 65 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 66 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 67 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 68 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 69 , , , work_wtnfwgpzqnfabpwucygbl35wyq 461 70 Seri Seri NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 71 M. M. NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 72 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 73 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 461 74 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 461 75 PAK3 PAK3 NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 76 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 461 77 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 461 78 dual dual JJ work_wtnfwgpzqnfabpwucygbl35wyq 461 79 molecular molecular JJ work_wtnfwgpzqnfabpwucygbl35wyq 461 80 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 461 81 deregulates deregulate VBZ work_wtnfwgpzqnfabpwucygbl35wyq 461 82 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 461 83 RAS RAS NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 84 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 461 85 MAPK MAPK NNP work_wtnfwgpzqnfabpwucygbl35wyq 461 86 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 461 87 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 461 88 drives drive VBZ work_wtnfwgpzqnfabpwucygbl35wyq 461 89 an an DT work_wtnfwgpzqnfabpwucygbl35wyq 461 90 X x NN work_wtnfwgpzqnfabpwucygbl35wyq 461 91 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 461 92 linked link VBN work_wtnfwgpzqnfabpwucygbl35wyq 461 93 syndromic syndromic JJ work_wtnfwgpzqnfabpwucygbl35wyq 461 94 phenotype phenotype NN work_wtnfwgpzqnfabpwucygbl35wyq 461 95 . . . work_wtnfwgpzqnfabpwucygbl35wyq 462 1 Hum Hum NNP work_wtnfwgpzqnfabpwucygbl35wyq 462 2 Mol Mol NNP work_wtnfwgpzqnfabpwucygbl35wyq 462 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 462 4 2014;23:3607–17 2014;23:3607–17 CD work_wtnfwgpzqnfabpwucygbl35wyq 462 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 463 1 42 42 CD work_wtnfwgpzqnfabpwucygbl35wyq 463 2 Margolin Margolin NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 3 DH DH NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 5 Kousi Kousi NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 6 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 8 Chan Chan NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 9 YM YM NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 11 Lim Lim NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 12 ET ET NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 14 Schmahmann Schmahmann NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 15 JD JD NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 17 Hadjivassiliou Hadjivassiliou NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 18 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 20 Hall Hall NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 21 JE JE NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 23 Adam Adam NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 24 I I NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 26 Dwyer Dwyer NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 27 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 29 Plummer Plummer NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 30 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 32 Aldrin Aldrin NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 33 SV SV NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 35 O’Rourke O’Rourke NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 36 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 37 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 38 Kirby Kirby NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 39 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 40 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 41 Lage Lage NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 42 K k NN work_wtnfwgpzqnfabpwucygbl35wyq 463 43 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 44 Milunsky Milunsky NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 45 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 46 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 47 Milunsky Milunsky NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 48 JM JM NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 49 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 50 Chan Chan NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 51 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 52 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 53 Hedley Hedley NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 54 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 463 55 Whyte Whyte NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 56 ET ET NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 57 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 58 Daly Daly NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 59 MJ MJ NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 60 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 61 Katsanis Katsanis NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 62 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 63 , , , work_wtnfwgpzqnfabpwucygbl35wyq 463 64 Seminara Seminara NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 65 SB SB NNP work_wtnfwgpzqnfabpwucygbl35wyq 463 66 . . . work_wtnfwgpzqnfabpwucygbl35wyq 464 1 Ataxia Ataxia NNP work_wtnfwgpzqnfabpwucygbl35wyq 464 2 , , , work_wtnfwgpzqnfabpwucygbl35wyq 464 3 dementia dementia NN work_wtnfwgpzqnfabpwucygbl35wyq 464 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 464 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 464 6 hypogonadotropism hypogonadotropism NNP work_wtnfwgpzqnfabpwucygbl35wyq 464 7 caused cause VBN work_wtnfwgpzqnfabpwucygbl35wyq 464 8 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 464 9 disordered disorder VBN work_wtnfwgpzqnfabpwucygbl35wyq 464 10 ubiquitination ubiquitination NN work_wtnfwgpzqnfabpwucygbl35wyq 464 11 . . . work_wtnfwgpzqnfabpwucygbl35wyq 465 1 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 465 2 Engl engl NN work_wtnfwgpzqnfabpwucygbl35wyq 465 3 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 465 4 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 465 5 2013;368:1992–2003 2013;368:1992–2003 NNP work_wtnfwgpzqnfabpwucygbl35wyq 465 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 466 1 43 43 CD work_wtnfwgpzqnfabpwucygbl35wyq 466 2 Martinez Martinez NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 466 4 Garay Garay NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 5 I I NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 466 7 Rustom Rustom NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 8 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 466 10 Gerdes Gerdes NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 11 HH HH NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 12 , , , work_wtnfwgpzqnfabpwucygbl35wyq 466 13 Kutsche Kutsche NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 14 K. K. NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 15 The the DT work_wtnfwgpzqnfabpwucygbl35wyq 466 16 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 466 17 centrosomal centrosomal NN work_wtnfwgpzqnfabpwucygbl35wyq 466 18 associated associate VBD work_wtnfwgpzqnfabpwucygbl35wyq 466 19 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 466 20 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 466 21 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 466 22 present present JJ work_wtnfwgpzqnfabpwucygbl35wyq 466 23 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 466 24 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 466 25 spindle spindle JJ work_wtnfwgpzqnfabpwucygbl35wyq 466 26 midzone midzone NN work_wtnfwgpzqnfabpwucygbl35wyq 466 27 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 466 28 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 466 29 midbody midbody NN work_wtnfwgpzqnfabpwucygbl35wyq 466 30 . . . work_wtnfwgpzqnfabpwucygbl35wyq 467 1 Genomics genomic NNS work_wtnfwgpzqnfabpwucygbl35wyq 467 2 2006;87:243–53 2006;87:243–53 NNP work_wtnfwgpzqnfabpwucygbl35wyq 467 3 . . . work_wtnfwgpzqnfabpwucygbl35wyq 468 1 44 44 CD work_wtnfwgpzqnfabpwucygbl35wyq 468 2 Morita Morita NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 3 E e NN work_wtnfwgpzqnfabpwucygbl35wyq 468 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 468 5 Colf Colf NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 6 LA LA NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 468 8 Karren Karren NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 9 MA MA NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 468 11 Sandrin Sandrin NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 12 V V NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 468 14 Rodesch Rodesch NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 15 CK CK NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 468 17 Sundquist Sundquist NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 18 WI WI NNP work_wtnfwgpzqnfabpwucygbl35wyq 468 19 . . . work_wtnfwgpzqnfabpwucygbl35wyq 469 1 Human Human NNP work_wtnfwgpzqnfabpwucygbl35wyq 469 2 ESCRT ESCRT NNP work_wtnfwgpzqnfabpwucygbl35wyq 469 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 469 4 III III NNP work_wtnfwgpzqnfabpwucygbl35wyq 469 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 469 6 VPS4 VPS4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 469 7 proteins protein NNS work_wtnfwgpzqnfabpwucygbl35wyq 469 8 are be VBP work_wtnfwgpzqnfabpwucygbl35wyq 469 9 required require VBN work_wtnfwgpzqnfabpwucygbl35wyq 469 10 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 469 11 centrosome centrosome NN work_wtnfwgpzqnfabpwucygbl35wyq 469 12 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 469 13 spindle spindle JJ work_wtnfwgpzqnfabpwucygbl35wyq 469 14 maintenance maintenance NN work_wtnfwgpzqnfabpwucygbl35wyq 469 15 . . . work_wtnfwgpzqnfabpwucygbl35wyq 470 1 Proc Proc NNP work_wtnfwgpzqnfabpwucygbl35wyq 470 2 Natl Natl NNP work_wtnfwgpzqnfabpwucygbl35wyq 470 3 Acad Acad NNP work_wtnfwgpzqnfabpwucygbl35wyq 470 4 Sci Sci NNP work_wtnfwgpzqnfabpwucygbl35wyq 470 5 USA USA NNP work_wtnfwgpzqnfabpwucygbl35wyq 470 6 2010;107:12889–94 2010;107:12889–94 CD work_wtnfwgpzqnfabpwucygbl35wyq 470 7 . . . work_wtnfwgpzqnfabpwucygbl35wyq 471 1 45 45 CD work_wtnfwgpzqnfabpwucygbl35wyq 471 2 Agromayor Agromayor NNP work_wtnfwgpzqnfabpwucygbl35wyq 471 3 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 471 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 471 5 Martin Martin NNP work_wtnfwgpzqnfabpwucygbl35wyq 471 6 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 471 7 Serrano Serrano NNP work_wtnfwgpzqnfabpwucygbl35wyq 471 8 J. J. NNP work_wtnfwgpzqnfabpwucygbl35wyq 472 1 Knowing know VBG work_wtnfwgpzqnfabpwucygbl35wyq 472 2 when when WRB work_wtnfwgpzqnfabpwucygbl35wyq 472 3 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 472 4 cut cut VB work_wtnfwgpzqnfabpwucygbl35wyq 472 5 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 472 6 run run VB work_wtnfwgpzqnfabpwucygbl35wyq 472 7 : : : work_wtnfwgpzqnfabpwucygbl35wyq 472 8 mechanisms mechanism NNS work_wtnfwgpzqnfabpwucygbl35wyq 472 9 that that WDT work_wtnfwgpzqnfabpwucygbl35wyq 472 10 control control VBP work_wtnfwgpzqnfabpwucygbl35wyq 472 11 cytokinetic cytokinetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 472 12 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 472 13 . . . work_wtnfwgpzqnfabpwucygbl35wyq 473 1 Trends Trends NNPS work_wtnfwgpzqnfabpwucygbl35wyq 473 2 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 473 3 Biol Biol NNP work_wtnfwgpzqnfabpwucygbl35wyq 473 4 2013;23:433–41 2013;23:433–41 CD work_wtnfwgpzqnfabpwucygbl35wyq 473 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 474 1 46 46 CD work_wtnfwgpzqnfabpwucygbl35wyq 474 2 St St NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 3 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 474 4 Denis Denis NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 5 N N NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 6 , , , work_wtnfwgpzqnfabpwucygbl35wyq 474 7 Gupta Gupta NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 8 GD GD NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 474 10 Lin Lin NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 11 ZY ZY NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 12 , , , work_wtnfwgpzqnfabpwucygbl35wyq 474 13 Gonzalez Gonzalez NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 14 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 474 15 Badillo Badillo NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 16 B B NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 17 , , , work_wtnfwgpzqnfabpwucygbl35wyq 474 18 Pelletier Pelletier NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 19 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 20 , , , work_wtnfwgpzqnfabpwucygbl35wyq 474 21 Gingras Gingras NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 22 AC AC NNP work_wtnfwgpzqnfabpwucygbl35wyq 474 23 . . . work_wtnfwgpzqnfabpwucygbl35wyq 475 1 Myotubularin Myotubularin NNP work_wtnfwgpzqnfabpwucygbl35wyq 475 2 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 475 3 related relate VBN work_wtnfwgpzqnfabpwucygbl35wyq 475 4 proteins protein NNS work_wtnfwgpzqnfabpwucygbl35wyq 475 5 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 475 6 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 475 7 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 475 8 interact interact NN work_wtnfwgpzqnfabpwucygbl35wyq 475 9 with with IN work_wtnfwgpzqnfabpwucygbl35wyq 475 10 polo polo NN work_wtnfwgpzqnfabpwucygbl35wyq 475 11 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 475 12 like like JJ work_wtnfwgpzqnfabpwucygbl35wyq 475 13 kinase kinase NN work_wtnfwgpzqnfabpwucygbl35wyq 475 14 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 475 15 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 475 16 centrosomal centrosomal NN work_wtnfwgpzqnfabpwucygbl35wyq 475 17 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 475 18 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 475 19 55 55 CD work_wtnfwgpzqnfabpwucygbl35wyq 475 20 kDa kDa NNS work_wtnfwgpzqnfabpwucygbl35wyq 475 21 to to TO work_wtnfwgpzqnfabpwucygbl35wyq 475 22 ensure ensure VB work_wtnfwgpzqnfabpwucygbl35wyq 475 23 proper proper JJ work_wtnfwgpzqnfabpwucygbl35wyq 475 24 abscission abscission NN work_wtnfwgpzqnfabpwucygbl35wyq 475 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 476 1 Mol Mol NNP work_wtnfwgpzqnfabpwucygbl35wyq 476 2 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 476 3 Proteomics Proteomics NNP work_wtnfwgpzqnfabpwucygbl35wyq 476 4 2015;14:946–60 2015;14:946–60 JJ work_wtnfwgpzqnfabpwucygbl35wyq 476 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 477 1 47 47 CD work_wtnfwgpzqnfabpwucygbl35wyq 477 2 Tsai Tsai NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 3 CY CY NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 477 5 Chen Chen NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 6 CH CH NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 477 8 Chang Chang NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 9 AY AY NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 477 11 Chan Chan NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 12 JY JY NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 477 14 Chan Chan NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 15 SH SH NNP work_wtnfwgpzqnfabpwucygbl35wyq 477 16 . . . work_wtnfwgpzqnfabpwucygbl35wyq 478 1 Upregulation upregulation NN work_wtnfwgpzqnfabpwucygbl35wyq 478 2 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 478 3 FLJ10540 FLJ10540 NNP work_wtnfwgpzqnfabpwucygbl35wyq 478 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 478 5 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 478 6 PI3K- PI3K- NNP work_wtnfwgpzqnfabpwucygbl35wyq 478 7 association association NN work_wtnfwgpzqnfabpwucygbl35wyq 478 8 protein protein NN work_wtnfwgpzqnfabpwucygbl35wyq 478 9 , , , work_wtnfwgpzqnfabpwucygbl35wyq 478 10 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 478 11 rostral rostral JJ work_wtnfwgpzqnfabpwucygbl35wyq 478 12 ventrolateral ventrolateral NNP work_wtnfwgpzqnfabpwucygbl35wyq 478 13 medulla medulla NNP work_wtnfwgpzqnfabpwucygbl35wyq 478 14 impairs impairs NNP work_wtnfwgpzqnfabpwucygbl35wyq 478 15 brain brain NNP work_wtnfwgpzqnfabpwucygbl35wyq 478 16 stem stem NN work_wtnfwgpzqnfabpwucygbl35wyq 478 17 cardiovascular cardiovascular JJ work_wtnfwgpzqnfabpwucygbl35wyq 478 18 regulation regulation NN work_wtnfwgpzqnfabpwucygbl35wyq 478 19 during during IN work_wtnfwgpzqnfabpwucygbl35wyq 478 20 mevinphos mevinpho NNS work_wtnfwgpzqnfabpwucygbl35wyq 478 21 intoxication intoxication NN work_wtnfwgpzqnfabpwucygbl35wyq 478 22 . . . work_wtnfwgpzqnfabpwucygbl35wyq 479 1 Biochem Biochem NNP work_wtnfwgpzqnfabpwucygbl35wyq 479 2 Pharmacol Pharmacol NNP work_wtnfwgpzqnfabpwucygbl35wyq 479 3 2015;93:34–41 2015;93:34–41 CD work_wtnfwgpzqnfabpwucygbl35wyq 479 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 480 1 48 48 CD work_wtnfwgpzqnfabpwucygbl35wyq 480 2 Luo Luo NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 3 T T NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 5 Liu Liu NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 6 G G NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 8 Ma Ma NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 9 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 11 Lu Lu NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 12 B B NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 14 Xu Xu NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 15 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 17 Wang Wang NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 18 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 20 Wu Wu NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 21 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 23 Ge Ge NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 24 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 480 26 Liang Liang NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 27 J. J. NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 28 Inhibition Inhibition NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 29 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 480 30 autophagy autophagy NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 31 via via IN work_wtnfwgpzqnfabpwucygbl35wyq 480 32 activation activation NN work_wtnfwgpzqnfabpwucygbl35wyq 480 33 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 480 34 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 35 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 480 36 Akt Akt NNP work_wtnfwgpzqnfabpwucygbl35wyq 480 37 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 480 38 contributes contribute VBZ work_wtnfwgpzqnfabpwucygbl35wyq 480 39 to to IN work_wtnfwgpzqnfabpwucygbl35wyq 480 40 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 480 41 protection protection NN work_wtnfwgpzqnfabpwucygbl35wyq 480 42 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 480 43 ginsenoside ginsenoside NN work_wtnfwgpzqnfabpwucygbl35wyq 480 44 Rb1 rb1 NN work_wtnfwgpzqnfabpwucygbl35wyq 480 45 against against IN work_wtnfwgpzqnfabpwucygbl35wyq 480 46 neuronal neuronal JJ work_wtnfwgpzqnfabpwucygbl35wyq 480 47 death death NN work_wtnfwgpzqnfabpwucygbl35wyq 480 48 caused cause VBN work_wtnfwgpzqnfabpwucygbl35wyq 480 49 by by IN work_wtnfwgpzqnfabpwucygbl35wyq 480 50 ischemic ischemic JJ work_wtnfwgpzqnfabpwucygbl35wyq 480 51 insults insult NNS work_wtnfwgpzqnfabpwucygbl35wyq 480 52 . . . work_wtnfwgpzqnfabpwucygbl35wyq 481 1 Int Int NNP work_wtnfwgpzqnfabpwucygbl35wyq 481 2 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 481 3 Mol Mol NNP work_wtnfwgpzqnfabpwucygbl35wyq 481 4 Sci Sci NNP work_wtnfwgpzqnfabpwucygbl35wyq 481 5 2014;15:15426–42 2014;15:15426–42 CD work_wtnfwgpzqnfabpwucygbl35wyq 481 6 . . . work_wtnfwgpzqnfabpwucygbl35wyq 482 1 49 49 CD work_wtnfwgpzqnfabpwucygbl35wyq 482 2 Zhang Zhang NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 3 L L NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 482 5 Qu Qu NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 6 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 482 8 Tang Tang NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 9 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 482 11 Chen Chen NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 12 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 482 14 Fu Fu NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 15 X X NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 482 17 Mao Mao NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 18 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 482 20 Mu Mu NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 21 D. D. NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 22 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 23 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 482 24 Akt Akt NNP work_wtnfwgpzqnfabpwucygbl35wyq 482 25 signaling signal VBG work_wtnfwgpzqnfabpwucygbl35wyq 482 26 pathway pathway NN work_wtnfwgpzqnfabpwucygbl35wyq 482 27 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 482 28 required require VBN work_wtnfwgpzqnfabpwucygbl35wyq 482 29 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 482 30 neuroprotection neuroprotection NN work_wtnfwgpzqnfabpwucygbl35wyq 482 31 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 482 32 thalidomide thalidomide NN work_wtnfwgpzqnfabpwucygbl35wyq 482 33 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 482 34 hypoxic hypoxic JJ work_wtnfwgpzqnfabpwucygbl35wyq 482 35 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 482 36 ischemic ischemic JJ work_wtnfwgpzqnfabpwucygbl35wyq 482 37 cortical cortical JJ work_wtnfwgpzqnfabpwucygbl35wyq 482 38 neurons neuron NNS work_wtnfwgpzqnfabpwucygbl35wyq 482 39 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 482 40 vitro vitro FW work_wtnfwgpzqnfabpwucygbl35wyq 482 41 . . . work_wtnfwgpzqnfabpwucygbl35wyq 483 1 Brain Brain NNP work_wtnfwgpzqnfabpwucygbl35wyq 483 2 Res Res NNP work_wtnfwgpzqnfabpwucygbl35wyq 483 3 2010;1357:157–65 2010;1357:157–65 CD work_wtnfwgpzqnfabpwucygbl35wyq 483 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 484 1 50 50 CD work_wtnfwgpzqnfabpwucygbl35wyq 484 2 Satake Satake NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 3 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 5 Takaoka Takaoka NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 6 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 7 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 8 Nishikawa Nishikawa NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 9 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 10 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 11 Yuba Yuba NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 12 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 13 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 14 Shibata Shibata NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 15 Y Y NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 16 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 17 Okumura Okumura NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 18 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 19 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 20 Kitano Kitano NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 21 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 22 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 23 Tsutsui Tsutsui NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 24 H H NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 25 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 26 Fujii Fujii NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 27 K K NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 28 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 29 Kobuchi Kobuchi NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 30 S S NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 31 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 32 Ohkita Ohkita NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 33 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 34 , , , work_wtnfwgpzqnfabpwucygbl35wyq 484 35 Matsumura Matsumura NNP work_wtnfwgpzqnfabpwucygbl35wyq 484 36 Y. Y. NNP work_wtnfwgpzqnfabpwucygbl35wyq 485 1 Protective protective JJ work_wtnfwgpzqnfabpwucygbl35wyq 485 2 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 485 3 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 485 4 17beta 17beta NN work_wtnfwgpzqnfabpwucygbl35wyq 485 5 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 485 6 estradiol estradiol NN work_wtnfwgpzqnfabpwucygbl35wyq 485 7 on on IN work_wtnfwgpzqnfabpwucygbl35wyq 485 8 ischemic ischemic JJ work_wtnfwgpzqnfabpwucygbl35wyq 485 9 acute acute JJ work_wtnfwgpzqnfabpwucygbl35wyq 485 10 renal renal JJ work_wtnfwgpzqnfabpwucygbl35wyq 485 11 failure failure NN work_wtnfwgpzqnfabpwucygbl35wyq 485 12 through through IN work_wtnfwgpzqnfabpwucygbl35wyq 485 13 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 485 14 PI3K PI3K NNP work_wtnfwgpzqnfabpwucygbl35wyq 485 15 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 485 16 Akt Akt NNP work_wtnfwgpzqnfabpwucygbl35wyq 485 17 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 485 18 eNOS enos NN work_wtnfwgpzqnfabpwucygbl35wyq 485 19 pathway pathway NNP work_wtnfwgpzqnfabpwucygbl35wyq 485 20 . . . work_wtnfwgpzqnfabpwucygbl35wyq 486 1 Kidney Kidney NNP work_wtnfwgpzqnfabpwucygbl35wyq 486 2 Int Int NNP work_wtnfwgpzqnfabpwucygbl35wyq 486 3 2008;73:308–17 2008;73:308–17 NNP work_wtnfwgpzqnfabpwucygbl35wyq 486 4 . . . work_wtnfwgpzqnfabpwucygbl35wyq 487 1 501Frosk 501Frosk NNP work_wtnfwgpzqnfabpwucygbl35wyq 487 2   _SP work_wtnfwgpzqnfabpwucygbl35wyq 487 3 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 487 4 , , , work_wtnfwgpzqnfabpwucygbl35wyq 487 5 et et NN work_wtnfwgpzqnfabpwucygbl35wyq 487 6   _SP work_wtnfwgpzqnfabpwucygbl35wyq 487 7 al al NNP work_wtnfwgpzqnfabpwucygbl35wyq 487 8 . . . work_wtnfwgpzqnfabpwucygbl35wyq 488 1 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 488 2 Med Med NNP work_wtnfwgpzqnfabpwucygbl35wyq 488 3 Genet Genet NNP work_wtnfwgpzqnfabpwucygbl35wyq 488 4 2017;54:490–501 2017;54:490–501 CD work_wtnfwgpzqnfabpwucygbl35wyq 488 5 . . . work_wtnfwgpzqnfabpwucygbl35wyq 489 1 doi:10.1136 doi:10.1136 NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 2 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 489 3 jmedgenet-2016 jmedgenet-2016 JJ work_wtnfwgpzqnfabpwucygbl35wyq 489 4 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 489 5 104296 104296 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 6 New New NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 7 loci loci NN work_wtnfwgpzqnfabpwucygbl35wyq 489 8 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 489 9 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 489 10 A A NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 11 p p NN work_wtnfwgpzqnfabpwucygbl35wyq 489 12 ril ril NN work_wtnfwgpzqnfabpwucygbl35wyq 489 13 5 5 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 14 , , , work_wtnfwgpzqnfabpwucygbl35wyq 489 15 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 16 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 17 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 18 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 19 b b NN work_wtnfwgpzqnfabpwucygbl35wyq 489 20 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 21 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 22 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 23 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 24 st st NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 25 . . . work_wtnfwgpzqnfabpwucygbl35wyq 489 26 P P NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 27 ro ro CC work_wtnfwgpzqnfabpwucygbl35wyq 489 28 te te NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 29 cte cte NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 30 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 31 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 32 y y NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 33 co co NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 34 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 35 yrig yrig NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 36 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 37 t. t. NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 38 h h NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 39 ttp ttp NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 40 : : : work_wtnfwgpzqnfabpwucygbl35wyq 489 41 //jm //jm . work_wtnfwgpzqnfabpwucygbl35wyq 489 42 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 43 .b .b . work_wtnfwgpzqnfabpwucygbl35wyq 489 44 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 45 j.co j.co NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 46 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 47 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 489 48 J J NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 49 M M NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 50 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 51 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 52 G g NN work_wtnfwgpzqnfabpwucygbl35wyq 489 53 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 54 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 55 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 56 t t NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 57 : : : work_wtnfwgpzqnfabpwucygbl35wyq 489 58 first first RB work_wtnfwgpzqnfabpwucygbl35wyq 489 59 p p NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 60 u u NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 61 b b NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 62 lish lish NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 63 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 64 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 65 a a NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 66 s s NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 67 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 68 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 69 .1 .1 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 70 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 71 3 3 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 72 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 73 /jm /jm SYM work_wtnfwgpzqnfabpwucygbl35wyq 489 74 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 75 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 76 g g NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 77 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 78 n n NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 79 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 80 t-2 t-2 NNP work_wtnfwgpzqnfabpwucygbl35wyq 489 81 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 82 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 83 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 84 -1 -1 NN work_wtnfwgpzqnfabpwucygbl35wyq 489 85 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 86 4 4 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 87 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 88 9 9 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 89 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 90 o o NN work_wtnfwgpzqnfabpwucygbl35wyq 489 91 n n NN work_wtnfwgpzqnfabpwucygbl35wyq 489 92 6 6 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 93 M m NN work_wtnfwgpzqnfabpwucygbl35wyq 489 94 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 489 95 rch rch NN work_wtnfwgpzqnfabpwucygbl35wyq 489 96 2 2 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 97 0 0 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 98 1 1 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 99 7 7 CD work_wtnfwgpzqnfabpwucygbl35wyq 489 100 . . . work_wtnfwgpzqnfabpwucygbl35wyq 490 1 D D NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 2 o o NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 3 w w NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 4 n n XX work_wtnfwgpzqnfabpwucygbl35wyq 490 5 lo lo NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 6 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 490 7 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 8 e e NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 9 d d NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 10 fro fro NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 11 m m NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 12 http://dx.doi.org/10.1534/genetics.114.168211 http://dx.doi.org/10.1534/genetics.114.168211 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 13 http://dx.doi.org/10.1016/B978-0-12-384892-5.00009-8 http://dx.doi.org/10.1016/B978-0-12-384892-5.00009-8 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 14 http://dx.doi.org/10.1016/j.ajhg.2014.03.017 http://dx.doi.org/10.1016/j.ajhg.2014.03.017 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 15 http://dx.doi.org/10.3791/50338 http://dx.doi.org/10.3791/50338 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 16 http://dx.doi.org/10.1073/pnas.0505774102 http://dx.doi.org/10.1073/pnas.0505774102 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 17 http://dx.doi.org/10.1073/pnas.0505774102 http://dx.doi.org/10.1073/pnas.0505774102 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 18 http://dx.doi.org/10.1371/journal.pone.0025400 http://dx.doi.org/10.1371/journal.pone.0025400 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 19 http://dx.doi.org/10.1016/j.ajhg.2016.07.003 http://dx.doi.org/10.1016/j.ajhg.2016.07.003 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 20 http://dx.doi.org/10.1002/jcu.1870120708 http://dx.doi.org/10.1002/jcu.1870120708 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 21 & & CC work_wtnfwgpzqnfabpwucygbl35wyq 490 22 nbsp;http://dx.doi.org/10.1002 nbsp;http://dx.doi.org/10.1002 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 23 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 490 24 ajmg.a.32061 ajmg.a.32061 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 25 & & CC work_wtnfwgpzqnfabpwucygbl35wyq 490 26 nbsp;http://dx.doi.org/10.1002 nbsp;http://dx.doi.org/10.1002 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 27 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 490 28 ajmg.a.32061 ajmg.a.32061 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 29 http://dx.doi.org/10.1016/j.bbagrm.2013.02.005 http://dx.doi.org/10.1016/j.bbagrm.2013.02.005 UH work_wtnfwgpzqnfabpwucygbl35wyq 490 30 http://dx.doi.org/10.1016/j.devcel.2005.09.003 http://dx.doi.org/10.1016/j.devcel.2005.09.003 UH work_wtnfwgpzqnfabpwucygbl35wyq 490 31 http://dx.doi.org/10.4161/cc.8.22.10047 http://dx.doi.org/10.4161/cc.8.22.10047 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 32 http://dx.doi.org/10.1038/ng.2892 http://dx.doi.org/10.1038/ng.2892 UH work_wtnfwgpzqnfabpwucygbl35wyq 490 33 http://dx.doi.org/10.1038/ng.2892 http://dx.doi.org/10.1038/ng.2892 UH work_wtnfwgpzqnfabpwucygbl35wyq 490 34 http://dx.doi.org/10.1083/jcb.201008108 http://dx.doi.org/10.1083/jcb.201008108 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 35 http://dx.doi.org/10.1074/jbc.M111.289108 http://dx.doi.org/10.1074/jbc.M111.289108 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 36 http://dx.doi.org/10.1097/CJI.0b013e3181a1d109 http://dx.doi.org/10.1097/CJI.0b013e3181a1d109 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 37 http://dx.doi.org/10.1091/mbc.E06-01-0015 http://dx.doi.org/10.1091/mbc.E06-01-0015 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 38 http://dx.doi.org/10.1158/0008-5472.CAN-09-0825 http://dx.doi.org/10.1158/0008-5472.CAN-09-0825 NNS work_wtnfwgpzqnfabpwucygbl35wyq 490 39 http://developinghumanbrain.org http://developinghumanbrain.org ADD work_wtnfwgpzqnfabpwucygbl35wyq 490 40 http://developinghumanbrain.org http://developinghumanbrain.org NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 41 http://dx.doi.org/10.1007/s11065-010-9148-4 http://dx.doi.org/10.1007/s11065-010-9148-4 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 42 http://dx.doi.org/10.1093/hmg/ddu070 http://dx.doi.org/10.1093/hmg/ddu070 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 43 http://dx.doi.org/10.1093/hmg/ddu070 http://dx.doi.org/10.1093/hmg/ddu070 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 44 http://dx.doi.org/10.1056/NEJMoa1215993 http://dx.doi.org/10.1056/NEJMoa1215993 JJR work_wtnfwgpzqnfabpwucygbl35wyq 490 45 http://dx.doi.org/10.1016/j.ygeno.2005.11.006 http://dx.doi.org/10.1016/j.ygeno.2005.11.006 NN work_wtnfwgpzqnfabpwucygbl35wyq 490 46 http://dx.doi.org/10.1073/pnas.1005938107 http://dx.doi.org/10.1073/pnas.1005938107 ADD work_wtnfwgpzqnfabpwucygbl35wyq 490 47 http://dx.doi.org/10.1016/j.tcb.2013.04.006 http://dx.doi.org/10.1016/j.tcb.2013.04.006 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 48 http://dx.doi.org/10.1074/mcp.M114.046086 http://dx.doi.org/10.1074/mcp.M114.046086 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 49 http://dx.doi.org/10.1016/j.bcp.2014.10.018 http://dx.doi.org/10.1016/j.bcp.2014.10.018 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 50 http://dx.doi.org/10.3390/ijms150915426 http://dx.doi.org/10.3390/ijms150915426 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 51 http://dx.doi.org/10.1016/j.brainres.2010.08.007 http://dx.doi.org/10.1016/j.brainres.2010.08.007 NN work_wtnfwgpzqnfabpwucygbl35wyq 490 52 http://dx.doi.org/10.1038/sj.ki.5002690 http://dx.doi.org/10.1038/sj.ki.5002690 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 53 http://jmg.bmj.com/ http://jmg.bmj.com/ NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 54 A a DT work_wtnfwgpzqnfabpwucygbl35wyq 490 55 truncating truncating JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 56 mutation mutation NN work_wtnfwgpzqnfabpwucygbl35wyq 490 57 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 490 58 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 59 is be VBZ work_wtnfwgpzqnfabpwucygbl35wyq 490 60 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 490 61 likely likely JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 62 cause cause NN work_wtnfwgpzqnfabpwucygbl35wyq 490 63 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 490 64 MARCH MARCH NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 65 , , , work_wtnfwgpzqnfabpwucygbl35wyq 490 66 a a DT work_wtnfwgpzqnfabpwucygbl35wyq 490 67 novel novel JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 68 syndrome syndrome NN work_wtnfwgpzqnfabpwucygbl35wyq 490 69 affecting affect VBG work_wtnfwgpzqnfabpwucygbl35wyq 490 70 neuronal neuronal JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 71 mitosis mitosis NN work_wtnfwgpzqnfabpwucygbl35wyq 490 72 Abstract Abstract NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 73 Introduction introduction NN work_wtnfwgpzqnfabpwucygbl35wyq 490 74 Methods Methods NNPS work_wtnfwgpzqnfabpwucygbl35wyq 490 75 Patient Patient NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 76 material material NN work_wtnfwgpzqnfabpwucygbl35wyq 490 77 Genetic genetic JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 78 mapping mapping NN work_wtnfwgpzqnfabpwucygbl35wyq 490 79 Exome Exome NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 80 sequencing sequencing NN work_wtnfwgpzqnfabpwucygbl35wyq 490 81 RNA RNA NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 82 isolation isolation NN work_wtnfwgpzqnfabpwucygbl35wyq 490 83 from from IN work_wtnfwgpzqnfabpwucygbl35wyq 490 84 patient patient JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 85 cells cell NNS work_wtnfwgpzqnfabpwucygbl35wyq 490 86 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 490 87 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 490 88 studies study NNS work_wtnfwgpzqnfabpwucygbl35wyq 490 89 using use VBG work_wtnfwgpzqnfabpwucygbl35wyq 490 90 RT RT NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 91 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 490 92 PCR PCR NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 93 Transient Transient NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 94 gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 490 95 suppression suppression NN work_wtnfwgpzqnfabpwucygbl35wyq 490 96 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 490 97 zebrafish zebrafish JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 98 embryos embryo NNS work_wtnfwgpzqnfabpwucygbl35wyq 490 99 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 100 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 490 101 CAS9 CAS9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 102 genome genome JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 103 editing editing NN work_wtnfwgpzqnfabpwucygbl35wyq 490 104 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 490 105 cep55l cep55l NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 106 NGS NGS NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 107 library library NN work_wtnfwgpzqnfabpwucygbl35wyq 490 108 preparation preparation NN work_wtnfwgpzqnfabpwucygbl35wyq 490 109 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 490 110 sequencing sequence VBG work_wtnfwgpzqnfabpwucygbl35wyq 490 111 for for IN work_wtnfwgpzqnfabpwucygbl35wyq 490 112 CRISPR CRISPR NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 113 / / SYM work_wtnfwgpzqnfabpwucygbl35wyq 490 114 CAS9 CAS9 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 115 outcomes outcome VBZ work_wtnfwgpzqnfabpwucygbl35wyq 490 116 Automated Automated NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 117 zebrafish zebrafish NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 118 imaging image VBG work_wtnfwgpzqnfabpwucygbl35wyq 490 119 Whole whole JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 120 mount mount JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 121 TUNEL TUNEL NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 122 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 490 123 immunostaining immunostaine VBG work_wtnfwgpzqnfabpwucygbl35wyq 490 124 Molecular molecular JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 125 cloning cloning NN work_wtnfwgpzqnfabpwucygbl35wyq 490 126 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 490 127 site site NN work_wtnfwgpzqnfabpwucygbl35wyq 490 128 - - HYPH work_wtnfwgpzqnfabpwucygbl35wyq 490 129 directed direct VBN work_wtnfwgpzqnfabpwucygbl35wyq 490 130 mutagenesis mutagenesis NN work_wtnfwgpzqnfabpwucygbl35wyq 490 131 Cell Cell NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 132 culture culture NN work_wtnfwgpzqnfabpwucygbl35wyq 490 133 , , , work_wtnfwgpzqnfabpwucygbl35wyq 490 134 transfections transfection NNS work_wtnfwgpzqnfabpwucygbl35wyq 490 135 and and CC work_wtnfwgpzqnfabpwucygbl35wyq 490 136 subcellular subcellular JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 137 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 490 138 Western western JJ work_wtnfwgpzqnfabpwucygbl35wyq 490 139 blotting blotting NN work_wtnfwgpzqnfabpwucygbl35wyq 490 140 Results Results NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 141 Clinical Clinical NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 142 features feature VBZ work_wtnfwgpzqnfabpwucygbl35wyq 490 143 Gene gene NN work_wtnfwgpzqnfabpwucygbl35wyq 490 144 identification identification NN work_wtnfwgpzqnfabpwucygbl35wyq 490 145 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 146 expression expression NN work_wtnfwgpzqnfabpwucygbl35wyq 490 147 Modelling model VBG work_wtnfwgpzqnfabpwucygbl35wyq 490 148 the the DT work_wtnfwgpzqnfabpwucygbl35wyq 490 149 effect effect NN work_wtnfwgpzqnfabpwucygbl35wyq 490 150 of of IN work_wtnfwgpzqnfabpwucygbl35wyq 490 151 CEP55 CEP55 NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 152 truncation truncation NN work_wtnfwgpzqnfabpwucygbl35wyq 490 153 in in IN work_wtnfwgpzqnfabpwucygbl35wyq 490 154 vivo vivo NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 155 Subcellular Subcellular NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 156 localisation localisation NN work_wtnfwgpzqnfabpwucygbl35wyq 490 157 Discussion Discussion NNP work_wtnfwgpzqnfabpwucygbl35wyq 490 158 References reference NNS