[PDF] Hepatic Parenchymal Injury in Crigler-Najjar Type I | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1097/MPG.0000000000001843 Corpus ID: 205851364Hepatic Parenchymal Injury in Crigler-Najjar Type I @article{Mitchell2018HepaticPI, title={Hepatic Parenchymal Injury in Crigler-Najjar Type I}, author={E. Mitchell and S. Ranganathan and P. McKiernan and Robert H. Squires and K. Strauss and K. Soltys and G. Mazariegos and J. Squires}, journal={Journal of Pediatric Gastroenterology and Nutrition}, year={2018}, volume={66}, pages={588–594} } E. Mitchell, S. Ranganathan, +5 authors J. Squires Published 2018 Medicine Journal of Pediatric Gastroenterology and Nutrition Background: Crigler-Najjar syndrome type I (CNI) arises from biallelic variants of UGT1A1 that abrogate uridine diphosphate glucuronosyltransferase (UGT1A1) activity resulting in unconjugated hyperbilirubinemia. Historically, liver parenchyma in CNI was considered structurally and histologically normal. Recent review of CNI liver explants revealed fibrosis. Our aim was to investigate the association between hepatic histology and disease phenotype in CNI. Methods: We extracted data from the… Expand View on Wolters Kluwer journals.lww.com Save to Library Create Alert Cite Launch Research Feed Share This Paper 9 CitationsHighly Influential Citations 2 Background Citations 5 View All Topics from this paper Fibrosis Uridine Diphosphate Aspartic Acid Hypertensive disease Liver parenchyma Transaminases Liver diseases Liver Dysfunction Crigler Najjar syndrome, type 1 Biliary calculi Alanine Transaminase Hypertension, Portal Unconjugated hyperbilirubinemia Cholelithiasis Tail t test Disease Phenotype SGOT - Glutamate oxaloacetate transaminase Physiological Sexual Disorders 9 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Liver Cirrhosis in a Patient with Crigler Najjar Syndrome Z. Barış, F. Özçay, Y. Usta, G. 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