[PDF] Rational Therapy from Bench to Bedside for a Rare Epilepsy | Semantic Scholar


    
    Skip to search formSkip to main content>



Semantic Scholar's Logo
Search




Sign InCreate Free Account


You are currently offline. Some features of the site may not work correctly.

	DOI:10.5698/1535-7597-14.5.286

Corpus ID: 12353783Rational Therapy from Bench to Bedside for a Rare Epilepsy
@article{Patino2014RationalTF,
  title={Rational Therapy from Bench to Bedside for a Rare Epilepsy},
  author={Gustavo A Patino and J. Parent},
  journal={Epilepsy Currents},
  year={2014},
  volume={14},
  pages={286 - 288}
}
	Gustavo A Patino, J. Parent
	Published 2014
	Medicine
	Epilepsy Currents

Commentary The Mammalian (also called Mechanistic) Target of Rapamycin (mTOR) is a protein kinase critical for integrating extracellular and intracellular signals to control multiple cell functions, including autophagy, RNA expression and translation, mitochondrial and lipid metabolism, cell polarity and growth, and cytoskeletal organization. mTOR hyperactivation has been linked to many human diseases, among them diabetes, cancer, and developmental brain malformations (1, 2). mTOR exerts its… Expand

View on SAGE
aesnet.org





Save to Library
Create Alert
Cite
Launch Research Feed





Share This Paper

2 Citations
View All









Topics from this paper


	Epilepsy










2 Citations



Citation Type
Citation Type

	All Types
	Cites Results
	Cites Methods
	Cites Background






Has PDF
Publication Type


Author


More Filters
More Filters
Filters

Sort by Relevance
Sort by Most Influenced Papers
Sort by Citation Count
Sort by Recency






The effect of translational medicine idea in training nerve internal medicine graduate students
	Wang Xiang-qing


Save
Alert
Research Feed




Management of long‐lasting phantosmia: a systematic review
	Mohamad Z Saltagi, Cyrus C. Rabbani, J. Ting, Thomas S Higgins
	Medicine
	International forum of allergy & rhinology
	2018

	5



Save
Alert
Research Feed








References


SHOWING 1-9 OF 9 REFERENCES

Dissecting the role of mTOR: lessons from mTOR inhibitors.
	R. Dowling, I. Topisirovic, B. Fonseca, N. Sonenberg
	Biology, Medicine
	Biochimica et biophysica acta
	2010

	385



	View 1 excerpt, references background



Save
Alert
Research Feed




mTOR: A pathogenic signaling pathway in developmental brain malformations.
	P. Crino
	Biology, Medicine
	Trends in molecular medicine
	2011

	195



	View 2 excerpts, references background



Save
Alert
Research Feed




Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex
	D. Franz
	Medicine
	Biologics : targets & therapy
	2013

	48

	PDF




Save
Alert
Research Feed




Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
	L. Zeng, Lin Xu, D. Gutmann, M. Wong
	Medicine
	Annals of neurology
	2008

	511

	




	View 1 excerpt, references background



Save
Alert
Research Feed




STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.
	K. Orlova, Whitney E. Parker, +6 authors P. Crino
	Biology, Medicine
	The Journal of clinical investigation
	2010

	87

	Highly Influential

	




	View 3 excerpts, references background



Save
Alert
Research Feed




Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases
	D. Lebwohl, Ö. Anak, +6 authors W. Berg
	Medicine
	Annals of the New York Academy of Sciences
	2013

	61



	View 1 excerpt, references background



Save
Alert
Research Feed




mTOR: from growth signal integration to cancer, diabetes and ageing
	R. Zoncu, A. Efeyan, D. Sabatini
	Biology, Medicine
	Nature Reviews Molecular Cell Biology
	2011

	3,243

	PDF





	View 1 excerpt, references background



Save
Alert
Research Feed




Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5.
	E. Puffenberger, K. Strauss, +10 authors D. Morton
	Medicine
	Brain : a journal of neurology
	2007

	94

	PDF




Save
Alert
Research Feed




STRADα deficiency results in aberrant mTORC 1 signaling during corticogenesis in humans and mice
	J Clin Invest
	2010






Related Papers

















	Abstract
	Topics
	2 Citations
	9 References
	Related Papers







Stay Connected With Semantic Scholar
Sign Up

About Semantic Scholar
Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI.
Learn More →

Resources
DatasetsSupp.aiAPIOpen Corpus
Organization
About UsResearchPublishing PartnersData Partners
 
FAQContact



Proudly built by AI2 with the help of our Collaborators
Terms of Service•Privacy Policy

The Allen Institute for AI


By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE