id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2020_05_15_090266	Zhang, R.	SpacePHARER: Sensitive identification of phages from CRISPR spacers in prokaryotic hosts	2021	6	.pdf	application/pdf	2191	283	64	Summary: SpacePHARER (CRISPR Spacer Phage-Host Pair Finder) is a sensitive and fast tool for de novo prediction of phage-host relationships via identifying phage genomes that match CRISPR spacers in genomic or metagenomic data. SpacePHARER gains sensitivity by comparing spacers and phages at the protein level, optimizing its scores for matching SpacePHARER by searching a comprehensive spacer list against all complete phage genomes. methods compare individual CRISPR spacers with phage To increase sensitivity, (1) we compare protein coding sequences because phage genomes are mostly coding, and, (0) Preprocess input: scan the phage genome and CRISPR spacers in six ORFs q of CRISPR spacers extracted from one prokaryotic genome, and each target set T comprises the putative protein sequences t from a single phage. The performance of SpacePHARER was evaluated on the spacer test set against a target database predicted the correct host for more phages than BLASTN BLASTN in detecting phage-host pairs, due to searching	./cache/10_1101-2020_05_15_090266.pdf	./txt/10_1101-2020_05_15_090266.txt