id author title date pages extension mime words sentences flesch summary cache txt 10_1101-2021_02_08_430343 Gibbs, David L Patient-specific cell communication networks associate with disease progression in cancer 2021 29 .pdf application/pdf 11335 1445 58 tumor microenvironment, the method identified ligands, receptors and cells meeting certain criteria of 56 9,234 samples in The Cancer Genome Atlas (TCGA), starting from a network of 64 cell types and 1,894 62 Data sources including TCGA and cell-sorted gene expression, bulk tumor expression, cell type scores, 78 ligands and receptors for each of the 64 cell types in xCell, using the source gene expression data. With this procedure, a network scaffold is induced, where cells produce ligands that bind to receptors on 113 (PFI) and tumor stage for each sample, a matrix of patient-specific edge weights was constructed 206 number of high weight edges in each tumor type did not associate with the number of samples, as might 254 in the tumor stage contrast, a majority of ligand-producing cells include GMP cells, Osteoblasts, MSC 283 In the PFI results, Th1 cells appeared in 13 high scoring edges in SKCM, all with 394 ./cache/10_1101-2021_02_08_430343.pdf ./txt/10_1101-2021_02_08_430343.txt