id author title date pages extension mime words sentences flesch summary cache txt work_zazrv4zhefcq3g772konheryvi J.C. Le Huec Epidemics over the centuries 2020 3 .pdf application/pdf 1687 156 68 epidemic was the Justinian plague which started in 540 AD, lasted for 2 centuries, and undoubtedly precipitated the fall of the Roman Empire.3 This was followed by the Black Death in the Middle Ages.4-6 which also originated in Asia, and lastly the bubonic plague pandemic, the third largest recorded, which originated in Yunnan during the 19th century, and the Middle Ages in Dubrovnik and then in Venice to isolate ships suspected of being carriers of the plague. on Marseilles5 in an effort to curb the Black Death which decimated more than 50,000 people in that city alone (Fig. 1). In France, Dr. Hyacinthe Vincent, despite popular reluctance, recommended wearing masks as protection against the Spanish flu, although its viral origin was not confirmed until 1933. First mask used during the plague of Paris in 1619. In 1920, after the Spanish flu epidemic, France established ./cache/work_zazrv4zhefcq3g772konheryvi.pdf ./txt/work_zazrv4zhefcq3g772konheryvi.txt