id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_p4knzwiifzc4zmyvc6lli6wn5q	Anya Plutynski	What and How Do Cancer Systems Biologists Explain?	2018	13	.pdf	application/pdf	5733	453	51	Second, we argue that some explanations in systems biology of cancer are concerned with properties of signaling networks This distinction is helpful in that it illuminates how systems biological explorations of cancer are often multiscale, building "up" from biochemistry and cell and molecular biology and, simultaneously, moving "down" organized, and mined to generate network models, for instance, documenting the co-occurrence of mutations or gene products in various cancer subtypes. In contrast, systems theoretical approaches can help us illuminate relevant features of ERBB network structure, which may contribute to its robustness, its role in our vulnerability to approaches help explain why certain kinds of circuitry and network structures are so common, across a variety of species (see, e.g., Levine and Davidson 2005) and how they come to play a role in cancer. particular genes mutated in cancer and then build a network model, a representation of both the organizational structure and dynamics of gene expression over time, as a tumor progresses.	./cache/work_p4knzwiifzc4zmyvc6lli6wn5q.pdf	./txt/work_p4knzwiifzc4zmyvc6lli6wn5q.txt