id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_c5k5k5nry5cytm2hgfefux36yy	Tunde Golenar	Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells	2012	1	.pdf	application/pdf	1456	116	36	mitochondrial membranes which result in the dramatic increase of their permeability. study investigated how mtDNA T8993G (NARP)-induced inhibition of mitochondrial complex V altered mitochondrial dynamics in association with a protective mitochondrial phospholipid, cardiolipin (CL), as a potential therapeutic a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca2þ and lipidstress. Intriguingly, melatonin, by differentially preserving CL during various stresses (oxidation > Ca2þ > lipid), rescuesdifferentially CL-altered mitochondrial dynamics and cell death (oxidation > CL to prevent its oxidization and/or depletion and, therefore, it exerts great potential in rescuing CL-dependent mitochondrial dynamics-associated mitochondrial pathologies for treatment of NARP-induced pathologies and diseases. MICU1 in mitochondrial Ca2þ uptake, we used wild type HeLa cells (Ctrl), mtDNA T8993G Mutation-Induced Mitochondrial Complex V Inhibition Augments Cardiolipin-Dependent Alterations of Mitochondria ... Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells Dichotomy between Mitochondrial Ca2+ Uptake and Martix [Ca2+] in MICU1 Deficient Cells	./cache/work_c5k5k5nry5cytm2hgfefux36yy.pdf	./txt/work_c5k5k5nry5cytm2hgfefux36yy.txt