id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_mjwbu5u4gbh5zkf4xswmmm2xja	Steven J. Thomson	N-Terminal Regulation of hERG1 K+ Channel Deactivation	2014	1	.pdf	application/pdf	1515	113	43	been used to measure binding affinity of Adnectin-A to the cell surface expressed receptor X to measure the effect of avidity of the multivalent adnectin the channel activation gate; and KChIP4a KID directly interacts with the T1 interaction between the voltage sensing domain and the intracellular activation gate underlies CSI (Bähring & Covarrubias, 2011, J Physiol 589:461studies of structural mechanisms of hERG channel activation by small molecules are truly novel. pharmacophore model for hERG channel openers using PHASE protocol. Pharmacophore model is also combined with previously developed receptorbased homology model of hERG K channel and novel activators are generated Slow deactivation of hERG1 (Kv 11.1) potassium channels maintains IKr during final repolarization of the cardiac action potential and opposes asynchronous early depolarization. A-Type Kv4 Channel Closed-State Inactivation is Modulated by the Tetramerization Domain Interacting with Auxilary KChIP4a Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Development and Validation Studies of Universal Pharmacophore Models for hERG Channel Openers	./cache/work_mjwbu5u4gbh5zkf4xswmmm2xja.pdf	./txt/work_mjwbu5u4gbh5zkf4xswmmm2xja.txt