id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_wgf2msbacfaetpobn6pl73o5ui	Melanie Paillard	The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver	2015	2	.pdf	application/pdf	3100	220	43	We investigated the kinetics of MAC inhibition in mitochondria from wild type, Bak, and Bax knockout cell lines using Mitochondrial Ca2þ has a critical role for balancing cell survival and death. Here we show that adrenergic signaling induces MCU tyrosine phosphorylation and accelerates mitochondrial Ca Pyk2 and MCU, which subsequently accelerates mitochondrial Ca2þ uptake via confirmed that only two tyrosine sites were phosphorylated in response to adrenergic stimulation in situ using cell lines stably expressing MCU-YFs. In addition, overexpression of these MCU-YFs failed to increase mitochondrial Ca elevation by thapsigargin, whereas wildtype MCU transfection dramatically accelerates mitochondrial Ca2þ uptake Mitochondrial Ca2þ uptake is central to oxidative metabolism and cell death The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver The Stoichiometry between MICU1 and MCU Determines the Different Mitochondrial Ca2+ Uptake Phenotypes in Heart and Liver	./cache/work_wgf2msbacfaetpobn6pl73o5ui.pdf	./txt/work_wgf2msbacfaetpobn6pl73o5ui.txt