id sid tid token lemma pos work_wgf2msbacfaetpobn6pl73o5ui 1 1 The the DT work_wgf2msbacfaetpobn6pl73o5ui 1 2 Stoichiometry Stoichiometry NNP work_wgf2msbacfaetpobn6pl73o5ui 1 3 between between IN work_wgf2msbacfaetpobn6pl73o5ui 1 4 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 1 5 and and CC work_wgf2msbacfaetpobn6pl73o5ui 1 6 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 1 7 Determines determine VBZ work_wgf2msbacfaetpobn6pl73o5ui 1 8 the the DT work_wgf2msbacfaetpobn6pl73o5ui 1 9 Different Different NNP work_wgf2msbacfaetpobn6pl73o5ui 1 10 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 1 11 Ca2 ca2 NN work_wgf2msbacfaetpobn6pl73o5ui 1 12 + + NFP work_wgf2msbacfaetpobn6pl73o5ui 1 13 Uptake Uptake NNP work_wgf2msbacfaetpobn6pl73o5ui 1 14 Phenotypes Phenotypes NNPS work_wgf2msbacfaetpobn6pl73o5ui 1 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 1 16 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 1 17 and and CC work_wgf2msbacfaetpobn6pl73o5ui 1 18 Liver Liver NNP work_wgf2msbacfaetpobn6pl73o5ui 1 19 Wednesday Wednesday NNP work_wgf2msbacfaetpobn6pl73o5ui 1 20 , , , work_wgf2msbacfaetpobn6pl73o5ui 1 21 February February NNP work_wgf2msbacfaetpobn6pl73o5ui 1 22 11 11 CD work_wgf2msbacfaetpobn6pl73o5ui 1 23 , , , work_wgf2msbacfaetpobn6pl73o5ui 1 24 2015 2015 CD work_wgf2msbacfaetpobn6pl73o5ui 1 25 609a 609a NNPS work_wgf2msbacfaetpobn6pl73o5ui 1 26 like like IN work_wgf2msbacfaetpobn6pl73o5ui 1 27 ursodeoxycholic ursodeoxycholic JJ work_wgf2msbacfaetpobn6pl73o5ui 1 28 acid acid NN work_wgf2msbacfaetpobn6pl73o5ui 1 29 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 1 30 UDCA UDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 1 31 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 1 32 and and CC work_wgf2msbacfaetpobn6pl73o5ui 1 33 tauroursodeoxycholic tauroursodeoxycholic JJ work_wgf2msbacfaetpobn6pl73o5ui 1 34 acid acid NN work_wgf2msbacfaetpobn6pl73o5ui 1 35 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 1 36 TUDCA TUDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 1 37 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 1 38 , , , work_wgf2msbacfaetpobn6pl73o5ui 1 39 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 1 40 cytoprotective cytoprotective JJ work_wgf2msbacfaetpobn6pl73o5ui 1 41 and and CC work_wgf2msbacfaetpobn6pl73o5ui 1 42 inhibit inhibit VB work_wgf2msbacfaetpobn6pl73o5ui 1 43 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 1 44 death death NN work_wgf2msbacfaetpobn6pl73o5ui 1 45 . . . work_wgf2msbacfaetpobn6pl73o5ui 2 1 The the DT work_wgf2msbacfaetpobn6pl73o5ui 2 2 mechanisms mechanism NNS work_wgf2msbacfaetpobn6pl73o5ui 2 3 associated associate VBN work_wgf2msbacfaetpobn6pl73o5ui 2 4 with with IN work_wgf2msbacfaetpobn6pl73o5ui 2 5 these these DT work_wgf2msbacfaetpobn6pl73o5ui 2 6 distinct distinct JJ work_wgf2msbacfaetpobn6pl73o5ui 2 7 effects effect NNS work_wgf2msbacfaetpobn6pl73o5ui 2 8 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 2 9 not not RB work_wgf2msbacfaetpobn6pl73o5ui 2 10 entirely entirely RB work_wgf2msbacfaetpobn6pl73o5ui 2 11 clear clear JJ work_wgf2msbacfaetpobn6pl73o5ui 2 12 . . . work_wgf2msbacfaetpobn6pl73o5ui 3 1 However however RB work_wgf2msbacfaetpobn6pl73o5ui 3 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 3 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 3 4 effect effect NN work_wgf2msbacfaetpobn6pl73o5ui 3 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 3 6 hydrophilic hydrophilic NNP work_wgf2msbacfaetpobn6pl73o5ui 3 7 bile bile NN work_wgf2msbacfaetpobn6pl73o5ui 3 8 acids acid NNS work_wgf2msbacfaetpobn6pl73o5ui 3 9 seems seem VBZ work_wgf2msbacfaetpobn6pl73o5ui 3 10 to to TO work_wgf2msbacfaetpobn6pl73o5ui 3 11 be be VB work_wgf2msbacfaetpobn6pl73o5ui 3 12 related relate VBN work_wgf2msbacfaetpobn6pl73o5ui 3 13 with with IN work_wgf2msbacfaetpobn6pl73o5ui 3 14 the the DT work_wgf2msbacfaetpobn6pl73o5ui 3 15 blockage blockage NN work_wgf2msbacfaetpobn6pl73o5ui 3 16 of of IN work_wgf2msbacfaetpobn6pl73o5ui 3 17 a a DT work_wgf2msbacfaetpobn6pl73o5ui 3 18 series series NN work_wgf2msbacfaetpobn6pl73o5ui 3 19 of of IN work_wgf2msbacfaetpobn6pl73o5ui 3 20 processes process NNS work_wgf2msbacfaetpobn6pl73o5ui 3 21 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 3 22 converge converge VBP work_wgf2msbacfaetpobn6pl73o5ui 3 23 on on IN work_wgf2msbacfaetpobn6pl73o5ui 3 24 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 3 25 damage damage NN work_wgf2msbacfaetpobn6pl73o5ui 3 26 . . . work_wgf2msbacfaetpobn6pl73o5ui 4 1 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 4 2 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 4 3 a a DT work_wgf2msbacfaetpobn6pl73o5ui 4 4 pro pro JJ work_wgf2msbacfaetpobn6pl73o5ui 4 5 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 4 6 apoptotic apoptotic JJ work_wgf2msbacfaetpobn6pl73o5ui 4 7 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 4 8 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 4 9 belongs belong VBZ work_wgf2msbacfaetpobn6pl73o5ui 4 10 to to IN work_wgf2msbacfaetpobn6pl73o5ui 4 11 the the DT work_wgf2msbacfaetpobn6pl73o5ui 4 12 superfamily superfamily NN work_wgf2msbacfaetpobn6pl73o5ui 4 13 of of IN work_wgf2msbacfaetpobn6pl73o5ui 4 14 the the DT work_wgf2msbacfaetpobn6pl73o5ui 4 15 Bcl-2 Bcl-2 NNP work_wgf2msbacfaetpobn6pl73o5ui 4 16 proteins protein NNS work_wgf2msbacfaetpobn6pl73o5ui 4 17 and and CC work_wgf2msbacfaetpobn6pl73o5ui 4 18 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 4 19 involved involve VBN work_wgf2msbacfaetpobn6pl73o5ui 4 20 in in IN work_wgf2msbacfaetpobn6pl73o5ui 4 21 mitochondrial mitochondrial JJ work_wgf2msbacfaetpobn6pl73o5ui 4 22 pore pore NN work_wgf2msbacfaetpobn6pl73o5ui 4 23 formation formation NN work_wgf2msbacfaetpobn6pl73o5ui 4 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 5 1 Submicellar submicellar JJ work_wgf2msbacfaetpobn6pl73o5ui 5 2 concentrations concentration NNS work_wgf2msbacfaetpobn6pl73o5ui 5 3 of of IN work_wgf2msbacfaetpobn6pl73o5ui 5 4 cytoprotective cytoprotective JJ work_wgf2msbacfaetpobn6pl73o5ui 5 5 bile bile NN work_wgf2msbacfaetpobn6pl73o5ui 5 6 acids acid NNS work_wgf2msbacfaetpobn6pl73o5ui 5 7 have have VBP work_wgf2msbacfaetpobn6pl73o5ui 5 8 been be VBN work_wgf2msbacfaetpobn6pl73o5ui 5 9 shown show VBN work_wgf2msbacfaetpobn6pl73o5ui 5 10 to to TO work_wgf2msbacfaetpobn6pl73o5ui 5 11 modulate modulate VB work_wgf2msbacfaetpobn6pl73o5ui 5 12 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 5 13 concentration concentration NN work_wgf2msbacfaetpobn6pl73o5ui 5 14 in in IN work_wgf2msbacfaetpobn6pl73o5ui 5 15 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 5 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 5 17 suggesting suggest VBG work_wgf2msbacfaetpobn6pl73o5ui 5 18 that that IN work_wgf2msbacfaetpobn6pl73o5ui 5 19 these these DT work_wgf2msbacfaetpobn6pl73o5ui 5 20 molecules molecule NNS work_wgf2msbacfaetpobn6pl73o5ui 5 21 may may MD work_wgf2msbacfaetpobn6pl73o5ui 5 22 interact interact VB work_wgf2msbacfaetpobn6pl73o5ui 5 23 directly directly RB work_wgf2msbacfaetpobn6pl73o5ui 5 24 with with IN work_wgf2msbacfaetpobn6pl73o5ui 5 25 the the DT work_wgf2msbacfaetpobn6pl73o5ui 5 26 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 5 27 . . . work_wgf2msbacfaetpobn6pl73o5ui 6 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 6 2 this this DT work_wgf2msbacfaetpobn6pl73o5ui 6 3 study study NN work_wgf2msbacfaetpobn6pl73o5ui 6 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 6 5 our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 6 6 objective objective NN work_wgf2msbacfaetpobn6pl73o5ui 6 7 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 6 8 to to TO work_wgf2msbacfaetpobn6pl73o5ui 6 9 evaluate evaluate VB work_wgf2msbacfaetpobn6pl73o5ui 6 10 the the DT work_wgf2msbacfaetpobn6pl73o5ui 6 11 affinity affinity NN work_wgf2msbacfaetpobn6pl73o5ui 6 12 of of IN work_wgf2msbacfaetpobn6pl73o5ui 6 13 bile bile NN work_wgf2msbacfaetpobn6pl73o5ui 6 14 acids acid NNS work_wgf2msbacfaetpobn6pl73o5ui 6 15 to to TO work_wgf2msbacfaetpobn6pl73o5ui 6 16 recombinant recombinant VB work_wgf2msbacfaetpobn6pl73o5ui 6 17 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 6 18 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 6 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 6 20 making make VBG work_wgf2msbacfaetpobn6pl73o5ui 6 21 use use NN work_wgf2msbacfaetpobn6pl73o5ui 6 22 of of IN work_wgf2msbacfaetpobn6pl73o5ui 6 23 fluorescence fluorescence NN work_wgf2msbacfaetpobn6pl73o5ui 6 24 spectroscopy spectroscopy NN work_wgf2msbacfaetpobn6pl73o5ui 6 25 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 6 26 FRET FRET NNP work_wgf2msbacfaetpobn6pl73o5ui 6 27 and and CC work_wgf2msbacfaetpobn6pl73o5ui 6 28 fluorescence fluorescence NN work_wgf2msbacfaetpobn6pl73o5ui 6 29 anisotropy anisotropy NN work_wgf2msbacfaetpobn6pl73o5ui 6 30 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 6 31 , , , work_wgf2msbacfaetpobn6pl73o5ui 6 32 as as RB work_wgf2msbacfaetpobn6pl73o5ui 6 33 well well RB work_wgf2msbacfaetpobn6pl73o5ui 6 34 as as IN work_wgf2msbacfaetpobn6pl73o5ui 6 35 Fluorescence Fluorescence NNP work_wgf2msbacfaetpobn6pl73o5ui 6 36 Correlation Correlation NNP work_wgf2msbacfaetpobn6pl73o5ui 6 37 Spectroscopy Spectroscopy NNP work_wgf2msbacfaetpobn6pl73o5ui 6 38 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 6 39 FCS FCS NNP work_wgf2msbacfaetpobn6pl73o5ui 6 40 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 6 41 . . . work_wgf2msbacfaetpobn6pl73o5ui 7 1 Our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 7 2 results result NNS work_wgf2msbacfaetpobn6pl73o5ui 7 3 show show VBP work_wgf2msbacfaetpobn6pl73o5ui 7 4 that that IN work_wgf2msbacfaetpobn6pl73o5ui 7 5 the the DT work_wgf2msbacfaetpobn6pl73o5ui 7 6 cytoprotective cytoprotective JJ work_wgf2msbacfaetpobn6pl73o5ui 7 7 bile bile NN work_wgf2msbacfaetpobn6pl73o5ui 7 8 acids acid VBZ work_wgf2msbacfaetpobn6pl73o5ui 7 9 UDCA UDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 7 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 7 11 TUDCA TUDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 7 12 associate associate NN work_wgf2msbacfaetpobn6pl73o5ui 7 13 with with IN work_wgf2msbacfaetpobn6pl73o5ui 7 14 recombinant recombinant JJ work_wgf2msbacfaetpobn6pl73o5ui 7 15 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 7 16 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 7 17 with with IN work_wgf2msbacfaetpobn6pl73o5ui 7 18 high high JJ work_wgf2msbacfaetpobn6pl73o5ui 7 19 affinity affinity NN work_wgf2msbacfaetpobn6pl73o5ui 7 20 , , , work_wgf2msbacfaetpobn6pl73o5ui 7 21 while while IN work_wgf2msbacfaetpobn6pl73o5ui 7 22 the the DT work_wgf2msbacfaetpobn6pl73o5ui 7 23 cytotoxic cytotoxic NNP work_wgf2msbacfaetpobn6pl73o5ui 7 24 bile bile NNP work_wgf2msbacfaetpobn6pl73o5ui 7 25 acid acid NNP work_wgf2msbacfaetpobn6pl73o5ui 7 26 DCA DCA NNP work_wgf2msbacfaetpobn6pl73o5ui 7 27 only only RB work_wgf2msbacfaetpobn6pl73o5ui 7 28 seems seem VBZ work_wgf2msbacfaetpobn6pl73o5ui 7 29 to to TO work_wgf2msbacfaetpobn6pl73o5ui 7 30 be be VB work_wgf2msbacfaetpobn6pl73o5ui 7 31 able able JJ work_wgf2msbacfaetpobn6pl73o5ui 7 32 to to TO work_wgf2msbacfaetpobn6pl73o5ui 7 33 adsorb adsorb VB work_wgf2msbacfaetpobn6pl73o5ui 7 34 to to IN work_wgf2msbacfaetpobn6pl73o5ui 7 35 the the DT work_wgf2msbacfaetpobn6pl73o5ui 7 36 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 7 37 with with IN work_wgf2msbacfaetpobn6pl73o5ui 7 38 much much RB work_wgf2msbacfaetpobn6pl73o5ui 7 39 lower low JJR work_wgf2msbacfaetpobn6pl73o5ui 7 40 affinity affinity NN work_wgf2msbacfaetpobn6pl73o5ui 7 41 . . . work_wgf2msbacfaetpobn6pl73o5ui 8 1 Notably notably RB work_wgf2msbacfaetpobn6pl73o5ui 8 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 8 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 8 4 bind- bind- NN work_wgf2msbacfaetpobn6pl73o5ui 8 5 ing ing NN work_wgf2msbacfaetpobn6pl73o5ui 8 6 site site NN work_wgf2msbacfaetpobn6pl73o5ui 8 7 for for IN work_wgf2msbacfaetpobn6pl73o5ui 8 8 UDCA UDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 8 9 seems seem VBZ work_wgf2msbacfaetpobn6pl73o5ui 8 10 to to TO work_wgf2msbacfaetpobn6pl73o5ui 8 11 be be VB work_wgf2msbacfaetpobn6pl73o5ui 8 12 located locate VBN work_wgf2msbacfaetpobn6pl73o5ui 8 13 in in IN work_wgf2msbacfaetpobn6pl73o5ui 8 14 a a DT work_wgf2msbacfaetpobn6pl73o5ui 8 15 hydrophobic hydrophobic JJ work_wgf2msbacfaetpobn6pl73o5ui 8 16 pocket pocket NN work_wgf2msbacfaetpobn6pl73o5ui 8 17 of of IN work_wgf2msbacfaetpobn6pl73o5ui 8 18 the the DT work_wgf2msbacfaetpobn6pl73o5ui 8 19 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 8 20 . . . work_wgf2msbacfaetpobn6pl73o5ui 9 1 This this DT work_wgf2msbacfaetpobn6pl73o5ui 9 2 interaction interaction NN work_wgf2msbacfaetpobn6pl73o5ui 9 3 could could MD work_wgf2msbacfaetpobn6pl73o5ui 9 4 be be VB work_wgf2msbacfaetpobn6pl73o5ui 9 5 responsible responsible JJ work_wgf2msbacfaetpobn6pl73o5ui 9 6 for for IN work_wgf2msbacfaetpobn6pl73o5ui 9 7 the the DT work_wgf2msbacfaetpobn6pl73o5ui 9 8 disruption disruption NN work_wgf2msbacfaetpobn6pl73o5ui 9 9 of of IN work_wgf2msbacfaetpobn6pl73o5ui 9 10 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 9 11 translocation translocation NN work_wgf2msbacfaetpobn6pl73o5ui 9 12 to to IN work_wgf2msbacfaetpobn6pl73o5ui 9 13 the the DT work_wgf2msbacfaetpobn6pl73o5ui 9 14 mitochondrial mitochondrial JJ work_wgf2msbacfaetpobn6pl73o5ui 9 15 outer outer JJ work_wgf2msbacfaetpobn6pl73o5ui 9 16 membrane membrane NN work_wgf2msbacfaetpobn6pl73o5ui 9 17 in in IN work_wgf2msbacfaetpobn6pl73o5ui 9 18 the the DT work_wgf2msbacfaetpobn6pl73o5ui 9 19 presence presence NN work_wgf2msbacfaetpobn6pl73o5ui 9 20 of of IN work_wgf2msbacfaetpobn6pl73o5ui 9 21 UDCA UDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 9 22 and/or and/or CC work_wgf2msbacfaetpobn6pl73o5ui 9 23 TUDCA TUDCA NNP work_wgf2msbacfaetpobn6pl73o5ui 9 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 10 1 Supported support VBN work_wgf2msbacfaetpobn6pl73o5ui 10 2 from from IN work_wgf2msbacfaetpobn6pl73o5ui 10 3 FCT FCT NNP work_wgf2msbacfaetpobn6pl73o5ui 10 4 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 10 5 Portugal Portugal NNP work_wgf2msbacfaetpobn6pl73o5ui 10 6 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 10 7 Projects Projects NNPS work_wgf2msbacfaetpobn6pl73o5ui 10 8 PTDC PTDC NNP work_wgf2msbacfaetpobn6pl73o5ui 10 9 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 10 10 QUI QUI NNP work_wgf2msbacfaetpobn6pl73o5ui 10 11 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 10 12 BIQ/119494/2010 BIQ/119494/2010 NNP work_wgf2msbacfaetpobn6pl73o5ui 10 13 and and CC work_wgf2msbacfaetpobn6pl73o5ui 10 14 RECI RECI NNP work_wgf2msbacfaetpobn6pl73o5ui 10 15 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 10 16 CTM CTM NNP work_wgf2msbacfaetpobn6pl73o5ui 10 17 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 10 18 POL/0342/2012 POL/0342/2012 NNP work_wgf2msbacfaetpobn6pl73o5ui 10 19 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 10 20 . . . work_wgf2msbacfaetpobn6pl73o5ui 11 1 T.S. T.S. NNP work_wgf2msbacfaetpobn6pl73o5ui 12 1 and and CC work_wgf2msbacfaetpobn6pl73o5ui 12 2 F.F. F.F. NNP work_wgf2msbacfaetpobn6pl73o5ui 13 1 acknowledges acknowledge VBZ work_wgf2msbacfaetpobn6pl73o5ui 13 2 FCT FCT NNP work_wgf2msbacfaetpobn6pl73o5ui 13 3 grants grant NNS work_wgf2msbacfaetpobn6pl73o5ui 13 4 SFRH SFRH NNP work_wgf2msbacfaetpobn6pl73o5ui 13 5 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 13 6 BD/92398/2013 BD/92398/2013 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 7 and and CC work_wgf2msbacfaetpobn6pl73o5ui 13 8 SFRH/ SFRH/ NNP work_wgf2msbacfaetpobn6pl73o5ui 13 9 BPD/64320/2009 BPD/64320/2009 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 10 3071-Pos 3071-pos SYM work_wgf2msbacfaetpobn6pl73o5ui 13 11 Board Board NNP work_wgf2msbacfaetpobn6pl73o5ui 13 12 B501 B501 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 13 MAC MAC NNP work_wgf2msbacfaetpobn6pl73o5ui 13 14 Inhibitors inhibitor NNS work_wgf2msbacfaetpobn6pl73o5ui 13 15 Neutralize neutralize VBP work_wgf2msbacfaetpobn6pl73o5ui 13 16 the the DT work_wgf2msbacfaetpobn6pl73o5ui 13 17 Pro pro JJ work_wgf2msbacfaetpobn6pl73o5ui 13 18 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 13 19 Apoptotic apoptotic JJ work_wgf2msbacfaetpobn6pl73o5ui 13 20 Effects Effects NNPS work_wgf2msbacfaetpobn6pl73o5ui 13 21 of of IN work_wgf2msbacfaetpobn6pl73o5ui 13 22 Tbid Tbid NNP work_wgf2msbacfaetpobn6pl73o5ui 13 23 Pablo Pablo NNP work_wgf2msbacfaetpobn6pl73o5ui 13 24 M. M. NNP work_wgf2msbacfaetpobn6pl73o5ui 13 25 Peixoto1 Peixoto1 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 26 , , , work_wgf2msbacfaetpobn6pl73o5ui 13 27 Oscar Oscar NNP work_wgf2msbacfaetpobn6pl73o5ui 13 28 H. H. NNP work_wgf2msbacfaetpobn6pl73o5ui 13 29 Teijido2 Teijido2 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 30 , , , work_wgf2msbacfaetpobn6pl73o5ui 13 31 Laurent Laurent NNP work_wgf2msbacfaetpobn6pl73o5ui 13 32 M. M. NNP work_wgf2msbacfaetpobn6pl73o5ui 13 33 Dejean3 Dejean3 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 34 , , , work_wgf2msbacfaetpobn6pl73o5ui 13 35 Evgeny Evgeny NNP work_wgf2msbacfaetpobn6pl73o5ui 13 36 Pavlov4 Pavlov4 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 37 , , , work_wgf2msbacfaetpobn6pl73o5ui 13 38 Bruno Bruno NNP work_wgf2msbacfaetpobn6pl73o5ui 13 39 Antonsson5 Antonsson5 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 40 , , , work_wgf2msbacfaetpobn6pl73o5ui 13 41 Kathleen Kathleen NNP work_wgf2msbacfaetpobn6pl73o5ui 13 42 W. W. NNP work_wgf2msbacfaetpobn6pl73o5ui 13 43 Kinnally4 Kinnally4 NNP work_wgf2msbacfaetpobn6pl73o5ui 13 44 . . . work_wgf2msbacfaetpobn6pl73o5ui 14 1 1Natural 1Natural NNP work_wgf2msbacfaetpobn6pl73o5ui 14 2 Sciences Sciences NNPS work_wgf2msbacfaetpobn6pl73o5ui 14 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 4 Baruch Baruch NNP work_wgf2msbacfaetpobn6pl73o5ui 14 5 College College NNP work_wgf2msbacfaetpobn6pl73o5ui 14 6 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 14 7 CUNY CUNY NNP work_wgf2msbacfaetpobn6pl73o5ui 14 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 9 New New NNP work_wgf2msbacfaetpobn6pl73o5ui 14 10 York York NNP work_wgf2msbacfaetpobn6pl73o5ui 14 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 12 NY NY NNP work_wgf2msbacfaetpobn6pl73o5ui 14 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 14 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 14 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 16 2National 2national CD work_wgf2msbacfaetpobn6pl73o5ui 14 17 Institute Institute NNP work_wgf2msbacfaetpobn6pl73o5ui 14 18 of of IN work_wgf2msbacfaetpobn6pl73o5ui 14 19 Child Child NNP work_wgf2msbacfaetpobn6pl73o5ui 14 20 Health Health NNP work_wgf2msbacfaetpobn6pl73o5ui 14 21 and and CC work_wgf2msbacfaetpobn6pl73o5ui 14 22 Human Human NNP work_wgf2msbacfaetpobn6pl73o5ui 14 23 Development Development NNP work_wgf2msbacfaetpobn6pl73o5ui 14 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 25 Baltimore Baltimore NNP work_wgf2msbacfaetpobn6pl73o5ui 14 26 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 27 MD MD NNP work_wgf2msbacfaetpobn6pl73o5ui 14 28 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 29 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 14 30 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 31 3 3 CD work_wgf2msbacfaetpobn6pl73o5ui 14 32 Chemistry Chemistry NNP work_wgf2msbacfaetpobn6pl73o5ui 14 33 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 34 California California NNP work_wgf2msbacfaetpobn6pl73o5ui 14 35 State State NNP work_wgf2msbacfaetpobn6pl73o5ui 14 36 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 14 37 of of IN work_wgf2msbacfaetpobn6pl73o5ui 14 38 Fresno Fresno NNP work_wgf2msbacfaetpobn6pl73o5ui 14 39 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 40 Fresno Fresno NNP work_wgf2msbacfaetpobn6pl73o5ui 14 41 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 42 CA CA NNP work_wgf2msbacfaetpobn6pl73o5ui 14 43 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 44 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 14 45 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 46 4 4 CD work_wgf2msbacfaetpobn6pl73o5ui 14 47 New New NNP work_wgf2msbacfaetpobn6pl73o5ui 14 48 York York NNP work_wgf2msbacfaetpobn6pl73o5ui 14 49 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 14 50 College College NNP work_wgf2msbacfaetpobn6pl73o5ui 14 51 of of IN work_wgf2msbacfaetpobn6pl73o5ui 14 52 Dentistry Dentistry NNP work_wgf2msbacfaetpobn6pl73o5ui 14 53 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 54 New New NNP work_wgf2msbacfaetpobn6pl73o5ui 14 55 York York NNP work_wgf2msbacfaetpobn6pl73o5ui 14 56 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 57 NY NY NNP work_wgf2msbacfaetpobn6pl73o5ui 14 58 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 59 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 14 60 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 61 5 5 CD work_wgf2msbacfaetpobn6pl73o5ui 14 62 Merck Merck NNP work_wgf2msbacfaetpobn6pl73o5ui 14 63 Serono Serono NNP work_wgf2msbacfaetpobn6pl73o5ui 14 64 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 65 Geneva Geneva NNP work_wgf2msbacfaetpobn6pl73o5ui 14 66 Research Research NNP work_wgf2msbacfaetpobn6pl73o5ui 14 67 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 14 68 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 69 Geneva Geneva NNP work_wgf2msbacfaetpobn6pl73o5ui 14 70 , , , work_wgf2msbacfaetpobn6pl73o5ui 14 71 Switzerland Switzerland NNP work_wgf2msbacfaetpobn6pl73o5ui 14 72 . . . work_wgf2msbacfaetpobn6pl73o5ui 15 1 Since since IN work_wgf2msbacfaetpobn6pl73o5ui 15 2 our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 15 3 initial initial JJ work_wgf2msbacfaetpobn6pl73o5ui 15 4 characterization characterization NN work_wgf2msbacfaetpobn6pl73o5ui 15 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 15 6 the the DT work_wgf2msbacfaetpobn6pl73o5ui 15 7 iMACs imacs CD work_wgf2msbacfaetpobn6pl73o5ui 15 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 15 9 different different JJ work_wgf2msbacfaetpobn6pl73o5ui 15 10 di di JJ work_wgf2msbacfaetpobn6pl73o5ui 15 11 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 15 12 bromocarbazole bromocarbazole NN work_wgf2msbacfaetpobn6pl73o5ui 15 13 derivatives derivative NNS work_wgf2msbacfaetpobn6pl73o5ui 15 14 with with IN work_wgf2msbacfaetpobn6pl73o5ui 15 15 anti anti JJ work_wgf2msbacfaetpobn6pl73o5ui 15 16 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 15 17 apoptotic apoptotic JJ work_wgf2msbacfaetpobn6pl73o5ui 15 18 function function NN work_wgf2msbacfaetpobn6pl73o5ui 15 19 have have VBP work_wgf2msbacfaetpobn6pl73o5ui 15 20 been be VBN work_wgf2msbacfaetpobn6pl73o5ui 15 21 developed develop VBN work_wgf2msbacfaetpobn6pl73o5ui 15 22 and and CC work_wgf2msbacfaetpobn6pl73o5ui 15 23 tested test VBN work_wgf2msbacfaetpobn6pl73o5ui 15 24 in in IN work_wgf2msbacfaetpobn6pl73o5ui 15 25 several several JJ work_wgf2msbacfaetpobn6pl73o5ui 15 26 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 15 27 models model NNS work_wgf2msbacfaetpobn6pl73o5ui 15 28 of of IN work_wgf2msbacfaetpobn6pl73o5ui 15 29 brain brain NN work_wgf2msbacfaetpobn6pl73o5ui 15 30 injury injury NN work_wgf2msbacfaetpobn6pl73o5ui 15 31 and and CC work_wgf2msbacfaetpobn6pl73o5ui 15 32 neurodegeneration neurodegeneration NN work_wgf2msbacfaetpobn6pl73o5ui 15 33 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 15 34 13 13 CD work_wgf2msbacfaetpobn6pl73o5ui 15 35 - - SYM work_wgf2msbacfaetpobn6pl73o5ui 15 36 21 21 CD work_wgf2msbacfaetpobn6pl73o5ui 15 37 ] ] -RRB- work_wgf2msbacfaetpobn6pl73o5ui 15 38 . . . work_wgf2msbacfaetpobn6pl73o5ui 16 1 Owing owe VBG work_wgf2msbacfaetpobn6pl73o5ui 16 2 to to IN work_wgf2msbacfaetpobn6pl73o5ui 16 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 16 4 increased increase VBN work_wgf2msbacfaetpobn6pl73o5ui 16 5 therapeutic therapeutic JJ work_wgf2msbacfaetpobn6pl73o5ui 16 6 potential potential NN work_wgf2msbacfaetpobn6pl73o5ui 16 7 of of IN work_wgf2msbacfaetpobn6pl73o5ui 16 8 anti anti JJ work_wgf2msbacfaetpobn6pl73o5ui 16 9 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 16 10 apoptotic apoptotic JJ work_wgf2msbacfaetpobn6pl73o5ui 16 11 di di JJ work_wgf2msbacfaetpobn6pl73o5ui 16 12 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 16 13 bromocarbazole bromocarbazole NN work_wgf2msbacfaetpobn6pl73o5ui 16 14 de- de- NN work_wgf2msbacfaetpobn6pl73o5ui 16 15 rivatives rivative VBZ work_wgf2msbacfaetpobn6pl73o5ui 16 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 16 17 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 16 18 sought seek VBD work_wgf2msbacfaetpobn6pl73o5ui 16 19 to to TO work_wgf2msbacfaetpobn6pl73o5ui 16 20 expand expand VB work_wgf2msbacfaetpobn6pl73o5ui 16 21 our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 16 22 knowledge knowledge NN work_wgf2msbacfaetpobn6pl73o5ui 16 23 of of IN work_wgf2msbacfaetpobn6pl73o5ui 16 24 the the DT work_wgf2msbacfaetpobn6pl73o5ui 16 25 mechanism mechanism NN work_wgf2msbacfaetpobn6pl73o5ui 16 26 of of IN work_wgf2msbacfaetpobn6pl73o5ui 16 27 action action NN work_wgf2msbacfaetpobn6pl73o5ui 16 28 of of IN work_wgf2msbacfaetpobn6pl73o5ui 16 29 these these DT work_wgf2msbacfaetpobn6pl73o5ui 16 30 small small JJ work_wgf2msbacfaetpobn6pl73o5ui 16 31 molecule molecule JJ work_wgf2msbacfaetpobn6pl73o5ui 16 32 inhibitors inhibitor NNS work_wgf2msbacfaetpobn6pl73o5ui 16 33 . . . work_wgf2msbacfaetpobn6pl73o5ui 17 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 17 2 investigated investigate VBD work_wgf2msbacfaetpobn6pl73o5ui 17 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 17 4 kinetics kinetic NNS work_wgf2msbacfaetpobn6pl73o5ui 17 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 17 6 MAC MAC NNP work_wgf2msbacfaetpobn6pl73o5ui 17 7 inhibi- inhibi- NN work_wgf2msbacfaetpobn6pl73o5ui 17 8 tion tion NN work_wgf2msbacfaetpobn6pl73o5ui 17 9 in in IN work_wgf2msbacfaetpobn6pl73o5ui 17 10 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 17 11 from from IN work_wgf2msbacfaetpobn6pl73o5ui 17 12 wild wild JJ work_wgf2msbacfaetpobn6pl73o5ui 17 13 type type NN work_wgf2msbacfaetpobn6pl73o5ui 17 14 , , , work_wgf2msbacfaetpobn6pl73o5ui 17 15 Bak Bak NNP work_wgf2msbacfaetpobn6pl73o5ui 17 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 17 17 and and CC work_wgf2msbacfaetpobn6pl73o5ui 17 18 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 17 19 knockout knockout JJ work_wgf2msbacfaetpobn6pl73o5ui 17 20 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 17 21 lines line NNS work_wgf2msbacfaetpobn6pl73o5ui 17 22 using use VBG work_wgf2msbacfaetpobn6pl73o5ui 17 23 patch patch NN work_wgf2msbacfaetpobn6pl73o5ui 17 24 clamp clamp NN work_wgf2msbacfaetpobn6pl73o5ui 17 25 electrophysiology electrophysiology NN work_wgf2msbacfaetpobn6pl73o5ui 17 26 , , , work_wgf2msbacfaetpobn6pl73o5ui 17 27 fluorescence fluorescence NN work_wgf2msbacfaetpobn6pl73o5ui 17 28 microscopy microscopy NN work_wgf2msbacfaetpobn6pl73o5ui 17 29 , , , work_wgf2msbacfaetpobn6pl73o5ui 17 30 ELISA ELISA NNP work_wgf2msbacfaetpobn6pl73o5ui 17 31 , , , work_wgf2msbacfaetpobn6pl73o5ui 17 32 and and CC work_wgf2msbacfaetpobn6pl73o5ui 17 33 quantita- quantita- VB work_wgf2msbacfaetpobn6pl73o5ui 17 34 tive tive JJ work_wgf2msbacfaetpobn6pl73o5ui 17 35 western western JJ work_wgf2msbacfaetpobn6pl73o5ui 17 36 blot blot NN work_wgf2msbacfaetpobn6pl73o5ui 17 37 analyses analysis NNS work_wgf2msbacfaetpobn6pl73o5ui 17 38 . . . work_wgf2msbacfaetpobn6pl73o5ui 18 1 Our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 18 2 results result NNS work_wgf2msbacfaetpobn6pl73o5ui 18 3 show show VBP work_wgf2msbacfaetpobn6pl73o5ui 18 4 that that IN work_wgf2msbacfaetpobn6pl73o5ui 18 5 iMACs imacs CD work_wgf2msbacfaetpobn6pl73o5ui 18 6 work work NN work_wgf2msbacfaetpobn6pl73o5ui 18 7 through through IN work_wgf2msbacfaetpobn6pl73o5ui 18 8 at at RB work_wgf2msbacfaetpobn6pl73o5ui 18 9 least least RBS work_wgf2msbacfaetpobn6pl73o5ui 18 10 two two CD work_wgf2msbacfaetpobn6pl73o5ui 18 11 mechanisms mechanism NNS work_wgf2msbacfaetpobn6pl73o5ui 18 12 : : : work_wgf2msbacfaetpobn6pl73o5ui 18 13 1 1 LS work_wgf2msbacfaetpobn6pl73o5ui 18 14 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 18 15 by by IN work_wgf2msbacfaetpobn6pl73o5ui 18 16 blocking block VBG work_wgf2msbacfaetpobn6pl73o5ui 18 17 relocation relocation NN work_wgf2msbacfaetpobn6pl73o5ui 18 18 of of IN work_wgf2msbacfaetpobn6pl73o5ui 18 19 the the DT work_wgf2msbacfaetpobn6pl73o5ui 18 20 cytoplasmic cytoplasmic JJ work_wgf2msbacfaetpobn6pl73o5ui 18 21 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 18 22 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 18 23 to to IN work_wgf2msbacfaetpobn6pl73o5ui 18 24 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 18 25 and and CC work_wgf2msbacfaetpobn6pl73o5ui 18 26 2 2 CD work_wgf2msbacfaetpobn6pl73o5ui 18 27 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 18 28 by by IN work_wgf2msbacfaetpobn6pl73o5ui 18 29 disassembling disassemble VBG work_wgf2msbacfaetpobn6pl73o5ui 18 30 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 18 31 oligomers oligomer NNS work_wgf2msbacfaetpobn6pl73o5ui 18 32 in in IN work_wgf2msbacfaetpobn6pl73o5ui 18 33 the the DT work_wgf2msbacfaetpobn6pl73o5ui 18 34 outer outer JJ work_wgf2msbacfaetpobn6pl73o5ui 18 35 membrane membrane NN work_wgf2msbacfaetpobn6pl73o5ui 18 36 . . . work_wgf2msbacfaetpobn6pl73o5ui 19 1 A a DT work_wgf2msbacfaetpobn6pl73o5ui 19 2 comparison comparison NN work_wgf2msbacfaetpobn6pl73o5ui 19 3 of of IN work_wgf2msbacfaetpobn6pl73o5ui 19 4 the the DT work_wgf2msbacfaetpobn6pl73o5ui 19 5 inhibitory inhibitory JJ work_wgf2msbacfaetpobn6pl73o5ui 19 6 effects effect NNS work_wgf2msbacfaetpobn6pl73o5ui 19 7 over over IN work_wgf2msbacfaetpobn6pl73o5ui 19 8 channel channel NN work_wgf2msbacfaetpobn6pl73o5ui 19 9 conductance conductance NN work_wgf2msbacfaetpobn6pl73o5ui 19 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 19 11 cyto- cyto- NNP work_wgf2msbacfaetpobn6pl73o5ui 19 12 chrome chrome NNP work_wgf2msbacfaetpobn6pl73o5ui 19 13 c c NNP work_wgf2msbacfaetpobn6pl73o5ui 19 14 release release NN work_wgf2msbacfaetpobn6pl73o5ui 19 15 suggests suggest VBZ work_wgf2msbacfaetpobn6pl73o5ui 19 16 that that IN work_wgf2msbacfaetpobn6pl73o5ui 19 17 the the DT work_wgf2msbacfaetpobn6pl73o5ui 19 18 iMACs imacs CD work_wgf2msbacfaetpobn6pl73o5ui 19 19 interacted interact VBN work_wgf2msbacfaetpobn6pl73o5ui 19 20 with with IN work_wgf2msbacfaetpobn6pl73o5ui 19 21 both both CC work_wgf2msbacfaetpobn6pl73o5ui 19 22 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 19 23 and and CC work_wgf2msbacfaetpobn6pl73o5ui 19 24 Bak Bak NNP work_wgf2msbacfaetpobn6pl73o5ui 19 25 with with IN work_wgf2msbacfaetpobn6pl73o5ui 19 26 similar similar JJ work_wgf2msbacfaetpobn6pl73o5ui 19 27 kinetics kinetic NNS work_wgf2msbacfaetpobn6pl73o5ui 19 28 . . . work_wgf2msbacfaetpobn6pl73o5ui 20 1 Interestingly interestingly RB work_wgf2msbacfaetpobn6pl73o5ui 20 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 20 3 wild wild JJ work_wgf2msbacfaetpobn6pl73o5ui 20 4 type type NN work_wgf2msbacfaetpobn6pl73o5ui 20 5 mitochondria mitochondrion NNS work_wgf2msbacfaetpobn6pl73o5ui 20 6 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 20 7 more more RBR work_wgf2msbacfaetpobn6pl73o5ui 20 8 suscep- suscep- JJ work_wgf2msbacfaetpobn6pl73o5ui 20 9 tible tible JJ work_wgf2msbacfaetpobn6pl73o5ui 20 10 to to IN work_wgf2msbacfaetpobn6pl73o5ui 20 11 inhibition inhibition NN work_wgf2msbacfaetpobn6pl73o5ui 20 12 than than IN work_wgf2msbacfaetpobn6pl73o5ui 20 13 the the DT work_wgf2msbacfaetpobn6pl73o5ui 20 14 Bak Bak NNP work_wgf2msbacfaetpobn6pl73o5ui 20 15 or or CC work_wgf2msbacfaetpobn6pl73o5ui 20 16 Bax Bax NNP work_wgf2msbacfaetpobn6pl73o5ui 20 17 knockouts knockout NNS work_wgf2msbacfaetpobn6pl73o5ui 20 18 . . . work_wgf2msbacfaetpobn6pl73o5ui 21 1 A a DT work_wgf2msbacfaetpobn6pl73o5ui 21 2 quantitative quantitative JJ work_wgf2msbacfaetpobn6pl73o5ui 21 3 western western JJ work_wgf2msbacfaetpobn6pl73o5ui 21 4 blot blot NN work_wgf2msbacfaetpobn6pl73o5ui 21 5 analysis analysis NN work_wgf2msbacfaetpobn6pl73o5ui 21 6 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 21 7 that that IN work_wgf2msbacfaetpobn6pl73o5ui 21 8 wild wild JJ work_wgf2msbacfaetpobn6pl73o5ui 21 9 type type NN work_wgf2msbacfaetpobn6pl73o5ui 21 10 mitochondria mitochondrion NNS work_wgf2msbacfaetpobn6pl73o5ui 21 11 had have VBD work_wgf2msbacfaetpobn6pl73o5ui 21 12 lower low JJR work_wgf2msbacfaetpobn6pl73o5ui 21 13 steady steady JJ work_wgf2msbacfaetpobn6pl73o5ui 21 14 state state NN work_wgf2msbacfaetpobn6pl73o5ui 21 15 levels level NNS work_wgf2msbacfaetpobn6pl73o5ui 21 16 of of IN work_wgf2msbacfaetpobn6pl73o5ui 21 17 Bak Bak NNP work_wgf2msbacfaetpobn6pl73o5ui 21 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 21 19 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 21 20 suggests suggest VBZ work_wgf2msbacfaetpobn6pl73o5ui 21 21 an an DT work_wgf2msbacfaetpobn6pl73o5ui 21 22 uneven uneven JJ work_wgf2msbacfaetpobn6pl73o5ui 21 23 stoichiometry stoichiometry NN work_wgf2msbacfaetpobn6pl73o5ui 21 24 of of IN work_wgf2msbacfaetpobn6pl73o5ui 21 25 the the DT work_wgf2msbacfaetpobn6pl73o5ui 21 26 MAC MAC NNP work_wgf2msbacfaetpobn6pl73o5ui 21 27 components component NNS work_wgf2msbacfaetpobn6pl73o5ui 21 28 . . . work_wgf2msbacfaetpobn6pl73o5ui 22 1 3072-Pos 3072-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 22 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 22 3 B502 B502 NNP work_wgf2msbacfaetpobn6pl73o5ui 22 4 Tyrosine Tyrosine NNP work_wgf2msbacfaetpobn6pl73o5ui 22 5 Phosphorylation Phosphorylation NNP work_wgf2msbacfaetpobn6pl73o5ui 22 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 22 7 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 22 8 Ca2D Ca2D NNP work_wgf2msbacfaetpobn6pl73o5ui 22 9 Uniporter Uniporter NNP work_wgf2msbacfaetpobn6pl73o5ui 22 10 Regulates Regulates NNP work_wgf2msbacfaetpobn6pl73o5ui 22 11 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 22 12 Ca2D Ca2D NNP work_wgf2msbacfaetpobn6pl73o5ui 22 13 Uptake Uptake NNP work_wgf2msbacfaetpobn6pl73o5ui 22 14 Jin Jin NNP work_wgf2msbacfaetpobn6pl73o5ui 22 15 O O NNP work_wgf2msbacfaetpobn6pl73o5ui 22 16 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 22 17 Uchi Uchi NNP work_wgf2msbacfaetpobn6pl73o5ui 22 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 22 19 Stephen Stephen NNP work_wgf2msbacfaetpobn6pl73o5ui 22 20 Hurst Hurst NNP work_wgf2msbacfaetpobn6pl73o5ui 22 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 22 22 Jyotsna Jyotsna NNP work_wgf2msbacfaetpobn6pl73o5ui 22 23 Mishra Mishra NNP work_wgf2msbacfaetpobn6pl73o5ui 22 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 22 25 Xiaole Xiaole NNP work_wgf2msbacfaetpobn6pl73o5ui 22 26 Xu Xu NNP work_wgf2msbacfaetpobn6pl73o5ui 22 27 , , , work_wgf2msbacfaetpobn6pl73o5ui 22 28 Bong Bong NNP work_wgf2msbacfaetpobn6pl73o5ui 22 29 Sook Sook NNP work_wgf2msbacfaetpobn6pl73o5ui 22 30 Jhun Jhun NNP work_wgf2msbacfaetpobn6pl73o5ui 22 31 , , , work_wgf2msbacfaetpobn6pl73o5ui 22 32 Shey Shey NNP work_wgf2msbacfaetpobn6pl73o5ui 22 33 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 22 34 Shing Shing NNP work_wgf2msbacfaetpobn6pl73o5ui 22 35 Sheu Sheu NNP work_wgf2msbacfaetpobn6pl73o5ui 22 36 . . . work_wgf2msbacfaetpobn6pl73o5ui 23 1 Depariment depariment NN work_wgf2msbacfaetpobn6pl73o5ui 23 2 of of IN work_wgf2msbacfaetpobn6pl73o5ui 23 3 Medicine Medicine NNP work_wgf2msbacfaetpobn6pl73o5ui 23 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 23 5 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 23 6 for for IN work_wgf2msbacfaetpobn6pl73o5ui 23 7 Translational Translational NNP work_wgf2msbacfaetpobn6pl73o5ui 23 8 Medicine Medicine NNP work_wgf2msbacfaetpobn6pl73o5ui 23 9 , , , work_wgf2msbacfaetpobn6pl73o5ui 23 10 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 23 11 Medical Medical NNP work_wgf2msbacfaetpobn6pl73o5ui 23 12 College College NNP work_wgf2msbacfaetpobn6pl73o5ui 23 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 23 14 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 23 15 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 23 16 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 23 17 , , , work_wgf2msbacfaetpobn6pl73o5ui 23 18 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 23 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 23 20 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 23 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 23 22 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 23 23 . . . work_wgf2msbacfaetpobn6pl73o5ui 24 1 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 24 2 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 24 3 has have VBZ work_wgf2msbacfaetpobn6pl73o5ui 24 4 a a DT work_wgf2msbacfaetpobn6pl73o5ui 24 5 critical critical JJ work_wgf2msbacfaetpobn6pl73o5ui 24 6 role role NN work_wgf2msbacfaetpobn6pl73o5ui 24 7 for for IN work_wgf2msbacfaetpobn6pl73o5ui 24 8 balancing balance VBG work_wgf2msbacfaetpobn6pl73o5ui 24 9 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 24 10 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 24 11 and and CC work_wgf2msbacfaetpobn6pl73o5ui 24 12 death death NN work_wgf2msbacfaetpobn6pl73o5ui 24 13 . . . work_wgf2msbacfaetpobn6pl73o5ui 25 1 Ca2þ Ca2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 25 2 influx influx NNP work_wgf2msbacfaetpobn6pl73o5ui 25 3 into into IN work_wgf2msbacfaetpobn6pl73o5ui 25 4 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 25 5 matrix matrix NN work_wgf2msbacfaetpobn6pl73o5ui 25 6 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 25 7 mediated mediate VBN work_wgf2msbacfaetpobn6pl73o5ui 25 8 primarily primarily RB work_wgf2msbacfaetpobn6pl73o5ui 25 9 by by IN work_wgf2msbacfaetpobn6pl73o5ui 25 10 the the DT work_wgf2msbacfaetpobn6pl73o5ui 25 11 mitochondrial mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 25 12 cal- cal- NNP work_wgf2msbacfaetpobn6pl73o5ui 25 13 cium cium NNP work_wgf2msbacfaetpobn6pl73o5ui 25 14 uniporter uniporter NNP work_wgf2msbacfaetpobn6pl73o5ui 25 15 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 25 16 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 25 17 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 25 18 . . . work_wgf2msbacfaetpobn6pl73o5ui 26 1 However however RB work_wgf2msbacfaetpobn6pl73o5ui 26 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 26 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 26 4 signaling signal VBG work_wgf2msbacfaetpobn6pl73o5ui 26 5 pathways pathway NNS work_wgf2msbacfaetpobn6pl73o5ui 26 6 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 26 7 regulate regulate VBP work_wgf2msbacfaetpobn6pl73o5ui 26 8 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 26 9 channel channel NN work_wgf2msbacfaetpobn6pl73o5ui 26 10 functions function NNS work_wgf2msbacfaetpobn6pl73o5ui 26 11 via via IN work_wgf2msbacfaetpobn6pl73o5ui 26 12 post post JJ work_wgf2msbacfaetpobn6pl73o5ui 26 13 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 26 14 translational translational JJ work_wgf2msbacfaetpobn6pl73o5ui 26 15 modifications modification NNS work_wgf2msbacfaetpobn6pl73o5ui 26 16 of of IN work_wgf2msbacfaetpobn6pl73o5ui 26 17 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 26 18 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 26 19 completely completely RB work_wgf2msbacfaetpobn6pl73o5ui 26 20 unknown unknown JJ work_wgf2msbacfaetpobn6pl73o5ui 26 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 27 1 Here here RB work_wgf2msbacfaetpobn6pl73o5ui 27 2 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 27 3 show show VBP work_wgf2msbacfaetpobn6pl73o5ui 27 4 that that IN work_wgf2msbacfaetpobn6pl73o5ui 27 5 adrenergic adrenergic JJ work_wgf2msbacfaetpobn6pl73o5ui 27 6 signaling signaling NN work_wgf2msbacfaetpobn6pl73o5ui 27 7 induces induce VBZ work_wgf2msbacfaetpobn6pl73o5ui 27 8 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 27 9 tyrosine tyrosine JJ work_wgf2msbacfaetpobn6pl73o5ui 27 10 phos- phos- JJ work_wgf2msbacfaetpobn6pl73o5ui 27 11 phorylation phorylation NN work_wgf2msbacfaetpobn6pl73o5ui 27 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 27 13 accelerates accelerate VBZ work_wgf2msbacfaetpobn6pl73o5ui 27 14 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 27 15 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 27 16 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 27 17 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 27 18 in in IN work_wgf2msbacfaetpobn6pl73o5ui 27 19 cardiac cardiac JJ work_wgf2msbacfaetpobn6pl73o5ui 27 20 cells cell NNS work_wgf2msbacfaetpobn6pl73o5ui 27 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 28 1 Adren- Adren- NNP work_wgf2msbacfaetpobn6pl73o5ui 28 2 ergic ergic JJ work_wgf2msbacfaetpobn6pl73o5ui 28 3 signaling signal VBG work_wgf2msbacfaetpobn6pl73o5ui 28 4 induces induce VBZ work_wgf2msbacfaetpobn6pl73o5ui 28 5 activation activation NN work_wgf2msbacfaetpobn6pl73o5ui 28 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 28 7 proline proline JJ work_wgf2msbacfaetpobn6pl73o5ui 28 8 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 28 9 rich rich JJ work_wgf2msbacfaetpobn6pl73o5ui 28 10 tyrosine tyrosine NN work_wgf2msbacfaetpobn6pl73o5ui 28 11 kinase kinase NN work_wgf2msbacfaetpobn6pl73o5ui 28 12 2 2 CD work_wgf2msbacfaetpobn6pl73o5ui 28 13 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 28 14 Pyk2 pyk2 NN work_wgf2msbacfaetpobn6pl73o5ui 28 15 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 28 16 and and CC work_wgf2msbacfaetpobn6pl73o5ui 28 17 translocation translocation NN work_wgf2msbacfaetpobn6pl73o5ui 28 18 into into IN work_wgf2msbacfaetpobn6pl73o5ui 28 19 the the DT work_wgf2msbacfaetpobn6pl73o5ui 28 20 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 28 21 matrix matrix NN work_wgf2msbacfaetpobn6pl73o5ui 28 22 ; ; : work_wgf2msbacfaetpobn6pl73o5ui 28 23 enhancing enhance VBG work_wgf2msbacfaetpobn6pl73o5ui 28 24 the the DT work_wgf2msbacfaetpobn6pl73o5ui 28 25 interaction interaction NN work_wgf2msbacfaetpobn6pl73o5ui 28 26 between between IN work_wgf2msbacfaetpobn6pl73o5ui 28 27 Pyk2 Pyk2 NNP work_wgf2msbacfaetpobn6pl73o5ui 28 28 and and CC work_wgf2msbacfaetpobn6pl73o5ui 28 29 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 28 30 , , , work_wgf2msbacfaetpobn6pl73o5ui 28 31 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 28 32 subsequently subsequently RB work_wgf2msbacfaetpobn6pl73o5ui 28 33 accelerates accelerate VBZ work_wgf2msbacfaetpobn6pl73o5ui 28 34 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 28 35 Ca2þ Ca2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 28 36 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 28 37 via via IN work_wgf2msbacfaetpobn6pl73o5ui 28 38 Pyk2-dependent pyk2-dependent NN work_wgf2msbacfaetpobn6pl73o5ui 28 39 MCU mcu NN work_wgf2msbacfaetpobn6pl73o5ui 28 40 tyrosine tyrosine NN work_wgf2msbacfaetpobn6pl73o5ui 28 41 phosphorylation phosphorylation NN work_wgf2msbacfaetpobn6pl73o5ui 28 42 . . . work_wgf2msbacfaetpobn6pl73o5ui 29 1 MCU mcu NN work_wgf2msbacfaetpobn6pl73o5ui 29 2 contains contain VBZ work_wgf2msbacfaetpobn6pl73o5ui 29 3 15 15 CD work_wgf2msbacfaetpobn6pl73o5ui 29 4 tyrosine tyrosine JJ work_wgf2msbacfaetpobn6pl73o5ui 29 5 res- res- NNS work_wgf2msbacfaetpobn6pl73o5ui 29 6 idues idue NNS work_wgf2msbacfaetpobn6pl73o5ui 29 7 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 29 8 5 5 CD work_wgf2msbacfaetpobn6pl73o5ui 29 9 in in IN work_wgf2msbacfaetpobn6pl73o5ui 29 10 the the DT work_wgf2msbacfaetpobn6pl73o5ui 29 11 N n NN work_wgf2msbacfaetpobn6pl73o5ui 29 12 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 29 13 terminus terminus NN work_wgf2msbacfaetpobn6pl73o5ui 29 14 , , , work_wgf2msbacfaetpobn6pl73o5ui 29 15 0 0 CD work_wgf2msbacfaetpobn6pl73o5ui 29 16 in in IN work_wgf2msbacfaetpobn6pl73o5ui 29 17 the the DT work_wgf2msbacfaetpobn6pl73o5ui 29 18 pore pore NN work_wgf2msbacfaetpobn6pl73o5ui 29 19 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 29 20 forming form VBG work_wgf2msbacfaetpobn6pl73o5ui 29 21 region region NN work_wgf2msbacfaetpobn6pl73o5ui 29 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 29 23 4 4 CD work_wgf2msbacfaetpobn6pl73o5ui 29 24 in in IN work_wgf2msbacfaetpobn6pl73o5ui 29 25 transmembrane transmembrane NNP work_wgf2msbacfaetpobn6pl73o5ui 29 26 do- do- JJ work_wgf2msbacfaetpobn6pl73o5ui 29 27 mains main NNS work_wgf2msbacfaetpobn6pl73o5ui 29 28 and and CC work_wgf2msbacfaetpobn6pl73o5ui 29 29 6 6 CD work_wgf2msbacfaetpobn6pl73o5ui 29 30 in in IN work_wgf2msbacfaetpobn6pl73o5ui 29 31 the the DT work_wgf2msbacfaetpobn6pl73o5ui 29 32 C c NN work_wgf2msbacfaetpobn6pl73o5ui 29 33 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 29 34 terminus terminus NN work_wgf2msbacfaetpobn6pl73o5ui 29 35 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 29 36 , , , work_wgf2msbacfaetpobn6pl73o5ui 29 37 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 29 38 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 29 39 conserved conserve VBN work_wgf2msbacfaetpobn6pl73o5ui 29 40 across across IN work_wgf2msbacfaetpobn6pl73o5ui 29 41 all all DT work_wgf2msbacfaetpobn6pl73o5ui 29 42 eukaryotic eukaryotic JJ work_wgf2msbacfaetpobn6pl73o5ui 29 43 species specie NNS work_wgf2msbacfaetpobn6pl73o5ui 29 44 . . . work_wgf2msbacfaetpobn6pl73o5ui 30 1 Among among IN work_wgf2msbacfaetpobn6pl73o5ui 30 2 them -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 30 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 30 4 only only RB work_wgf2msbacfaetpobn6pl73o5ui 30 5 3 3 CD work_wgf2msbacfaetpobn6pl73o5ui 30 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 30 7 these these DT work_wgf2msbacfaetpobn6pl73o5ui 30 8 tyrosine tyrosine JJ work_wgf2msbacfaetpobn6pl73o5ui 30 9 residues residue NNS work_wgf2msbacfaetpobn6pl73o5ui 30 10 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 30 11 Y157 y157 NN work_wgf2msbacfaetpobn6pl73o5ui 30 12 at at IN work_wgf2msbacfaetpobn6pl73o5ui 30 13 N n NN work_wgf2msbacfaetpobn6pl73o5ui 30 14 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 30 15 terminus terminus NN work_wgf2msbacfaetpobn6pl73o5ui 30 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 30 17 Y288 Y288 NNP work_wgf2msbacfaetpobn6pl73o5ui 30 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 30 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 30 20 Y316 Y316 NNP work_wgf2msbacfaetpobn6pl73o5ui 30 21 at at IN work_wgf2msbacfaetpobn6pl73o5ui 30 22 C C NNP work_wgf2msbacfaetpobn6pl73o5ui 30 23 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 30 24 terminus terminus NN work_wgf2msbacfaetpobn6pl73o5ui 30 25 in in IN work_wgf2msbacfaetpobn6pl73o5ui 30 26 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 30 27 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 30 28 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 30 29 remained remain VBD work_wgf2msbacfaetpobn6pl73o5ui 30 30 as as IN work_wgf2msbacfaetpobn6pl73o5ui 30 31 potential potential JJ work_wgf2msbacfaetpobn6pl73o5ui 30 32 phosphor- phosphor- NN work_wgf2msbacfaetpobn6pl73o5ui 30 33 ylation ylation NN work_wgf2msbacfaetpobn6pl73o5ui 30 34 candidate candidate NN work_wgf2msbacfaetpobn6pl73o5ui 30 35 sites site NNS work_wgf2msbacfaetpobn6pl73o5ui 30 36 for for IN work_wgf2msbacfaetpobn6pl73o5ui 30 37 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 30 38 tyrosine tyrosine NN work_wgf2msbacfaetpobn6pl73o5ui 30 39 kinases kinase NNS work_wgf2msbacfaetpobn6pl73o5ui 30 40 using use VBG work_wgf2msbacfaetpobn6pl73o5ui 30 41 phosphorylation phosphorylation NN work_wgf2msbacfaetpobn6pl73o5ui 30 42 predic- predic- NN work_wgf2msbacfaetpobn6pl73o5ui 30 43 tion tion NN work_wgf2msbacfaetpobn6pl73o5ui 30 44 programs program NNS work_wgf2msbacfaetpobn6pl73o5ui 30 45 . . . work_wgf2msbacfaetpobn6pl73o5ui 31 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 31 2 mutated mutate VBD work_wgf2msbacfaetpobn6pl73o5ui 31 3 these these DT work_wgf2msbacfaetpobn6pl73o5ui 31 4 tyrosine tyrosine JJ work_wgf2msbacfaetpobn6pl73o5ui 31 5 residues residue NNS work_wgf2msbacfaetpobn6pl73o5ui 31 6 to to TO work_wgf2msbacfaetpobn6pl73o5ui 31 7 phenylalanine phenylalanine VB work_wgf2msbacfaetpobn6pl73o5ui 31 8 and and CC work_wgf2msbacfaetpobn6pl73o5ui 31 9 generated generate VBD work_wgf2msbacfaetpobn6pl73o5ui 31 10 non non JJ work_wgf2msbacfaetpobn6pl73o5ui 31 11 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 31 12 phosphorylation phosphorylation JJ work_wgf2msbacfaetpobn6pl73o5ui 31 13 mimetic mimetic JJ work_wgf2msbacfaetpobn6pl73o5ui 31 14 MCU mcu NN work_wgf2msbacfaetpobn6pl73o5ui 31 15 mutants mutant NNS work_wgf2msbacfaetpobn6pl73o5ui 31 16 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 31 17 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 31 18 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 31 19 YFs YFs NNP work_wgf2msbacfaetpobn6pl73o5ui 31 20 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 31 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 32 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 32 2 confirmed confirm VBD work_wgf2msbacfaetpobn6pl73o5ui 32 3 that that IN work_wgf2msbacfaetpobn6pl73o5ui 32 4 only only RB work_wgf2msbacfaetpobn6pl73o5ui 32 5 two two CD work_wgf2msbacfaetpobn6pl73o5ui 32 6 tyrosine tyrosine JJ work_wgf2msbacfaetpobn6pl73o5ui 32 7 sites site NNS work_wgf2msbacfaetpobn6pl73o5ui 32 8 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 32 9 phosphorylated phosphorylate VBN work_wgf2msbacfaetpobn6pl73o5ui 32 10 in in IN work_wgf2msbacfaetpobn6pl73o5ui 32 11 response response NN work_wgf2msbacfaetpobn6pl73o5ui 32 12 to to IN work_wgf2msbacfaetpobn6pl73o5ui 32 13 adren- adren- VB work_wgf2msbacfaetpobn6pl73o5ui 32 14 ergic ergic JJ work_wgf2msbacfaetpobn6pl73o5ui 32 15 stimulation stimulation NN work_wgf2msbacfaetpobn6pl73o5ui 32 16 in in IN work_wgf2msbacfaetpobn6pl73o5ui 32 17 situ situ NN work_wgf2msbacfaetpobn6pl73o5ui 32 18 using use VBG work_wgf2msbacfaetpobn6pl73o5ui 32 19 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 32 20 lines line NNS work_wgf2msbacfaetpobn6pl73o5ui 32 21 stably stably RB work_wgf2msbacfaetpobn6pl73o5ui 32 22 expressing express VBG work_wgf2msbacfaetpobn6pl73o5ui 32 23 MCU mcu NN work_wgf2msbacfaetpobn6pl73o5ui 32 24 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 32 25 YFs YFs NNP work_wgf2msbacfaetpobn6pl73o5ui 32 26 . . . work_wgf2msbacfaetpobn6pl73o5ui 33 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 33 2 addi- addi- JJ work_wgf2msbacfaetpobn6pl73o5ui 33 3 tion tion NN work_wgf2msbacfaetpobn6pl73o5ui 33 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 33 5 overexpression overexpression NN work_wgf2msbacfaetpobn6pl73o5ui 33 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 33 7 these these DT work_wgf2msbacfaetpobn6pl73o5ui 33 8 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 33 9 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 33 10 YFs YFs NNP work_wgf2msbacfaetpobn6pl73o5ui 33 11 failed fail VBD work_wgf2msbacfaetpobn6pl73o5ui 33 12 to to TO work_wgf2msbacfaetpobn6pl73o5ui 33 13 increase increase VB work_wgf2msbacfaetpobn6pl73o5ui 33 14 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 33 15 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 33 16 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 33 17 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 33 18 in in IN work_wgf2msbacfaetpobn6pl73o5ui 33 19 response response NN work_wgf2msbacfaetpobn6pl73o5ui 33 20 to to IN work_wgf2msbacfaetpobn6pl73o5ui 33 21 cytosolic cytosolic NNP work_wgf2msbacfaetpobn6pl73o5ui 33 22 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 33 23 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 33 24 elevation elevation NN work_wgf2msbacfaetpobn6pl73o5ui 33 25 by by IN work_wgf2msbacfaetpobn6pl73o5ui 33 26 thapsigargin thapsigargin NN work_wgf2msbacfaetpobn6pl73o5ui 33 27 , , , work_wgf2msbacfaetpobn6pl73o5ui 33 28 whereas whereas IN work_wgf2msbacfaetpobn6pl73o5ui 33 29 wild- wild- NN work_wgf2msbacfaetpobn6pl73o5ui 33 30 type type NN work_wgf2msbacfaetpobn6pl73o5ui 33 31 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 33 32 transfection transfection NN work_wgf2msbacfaetpobn6pl73o5ui 33 33 dramatically dramatically RB work_wgf2msbacfaetpobn6pl73o5ui 33 34 accelerates accelerate VBZ work_wgf2msbacfaetpobn6pl73o5ui 33 35 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 33 36 Ca2þ Ca2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 33 37 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 33 38 compared compare VBN work_wgf2msbacfaetpobn6pl73o5ui 33 39 to to IN work_wgf2msbacfaetpobn6pl73o5ui 33 40 non non JJ work_wgf2msbacfaetpobn6pl73o5ui 33 41 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 33 42 transfected transfected JJ work_wgf2msbacfaetpobn6pl73o5ui 33 43 cells cell NNS work_wgf2msbacfaetpobn6pl73o5ui 33 44 . . . work_wgf2msbacfaetpobn6pl73o5ui 34 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 34 2 summary summary NN work_wgf2msbacfaetpobn6pl73o5ui 34 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 34 4 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 34 5 contains contain VBZ work_wgf2msbacfaetpobn6pl73o5ui 34 6 Pyk2-specific pyk2-specific DT work_wgf2msbacfaetpobn6pl73o5ui 34 7 phosphorylation phosphorylation NN work_wgf2msbacfaetpobn6pl73o5ui 34 8 site(s site(s NNP work_wgf2msbacfaetpobn6pl73o5ui 34 9 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 34 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 34 11 Pyk2-dependent pyk2-dependent NN work_wgf2msbacfaetpobn6pl73o5ui 34 12 tyrosine tyrosine JJ work_wgf2msbacfaetpobn6pl73o5ui 34 13 phosphorylation phosphorylation NN work_wgf2msbacfaetpobn6pl73o5ui 34 14 of of IN work_wgf2msbacfaetpobn6pl73o5ui 34 15 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 34 16 can can MD work_wgf2msbacfaetpobn6pl73o5ui 34 17 modulate modulate VB work_wgf2msbacfaetpobn6pl73o5ui 34 18 its -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 34 19 channel channel NN work_wgf2msbacfaetpobn6pl73o5ui 34 20 functions function NNS work_wgf2msbacfaetpobn6pl73o5ui 34 21 and and CC work_wgf2msbacfaetpobn6pl73o5ui 34 22 regulate regulate VB work_wgf2msbacfaetpobn6pl73o5ui 34 23 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 34 24 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 34 25 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 34 26 uptake uptake VB work_wgf2msbacfaetpobn6pl73o5ui 34 27 . . . work_wgf2msbacfaetpobn6pl73o5ui 35 1 3073-Pos 3073-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 35 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 35 3 B503 B503 NNP work_wgf2msbacfaetpobn6pl73o5ui 35 4 Cardioprotective Cardioprotective NNP work_wgf2msbacfaetpobn6pl73o5ui 35 5 Roles Roles NNPS work_wgf2msbacfaetpobn6pl73o5ui 35 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 35 7 Neuronal Neuronal NNP work_wgf2msbacfaetpobn6pl73o5ui 35 8 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 35 9 2D 2d VB work_wgf2msbacfaetpobn6pl73o5ui 35 10 Sensor-1 Sensor-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 35 11 during during IN work_wgf2msbacfaetpobn6pl73o5ui 35 12 Stress Stress NNP work_wgf2msbacfaetpobn6pl73o5ui 35 13 Tomoe Tomoe NNP work_wgf2msbacfaetpobn6pl73o5ui 35 14 Y. Y. NNP work_wgf2msbacfaetpobn6pl73o5ui 35 15 Nakamura Nakamura NNP work_wgf2msbacfaetpobn6pl73o5ui 35 16 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 35 17 Nishitani1 Nishitani1 NNP work_wgf2msbacfaetpobn6pl73o5ui 35 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 35 19 Shu Shu NNP work_wgf2msbacfaetpobn6pl73o5ui 35 20 Nakao1 Nakao1 NNP work_wgf2msbacfaetpobn6pl73o5ui 35 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 35 22 Shigeo Shigeo NNP work_wgf2msbacfaetpobn6pl73o5ui 35 23 Wakabayashi2 Wakabayashi2 NNP work_wgf2msbacfaetpobn6pl73o5ui 35 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 1 1Molecular 1Molecular NNP work_wgf2msbacfaetpobn6pl73o5ui 36 2 Physiology Physiology NNP work_wgf2msbacfaetpobn6pl73o5ui 36 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 4 Natl Natl NNP work_wgf2msbacfaetpobn6pl73o5ui 36 5 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 6 Cer Cer NNP work_wgf2msbacfaetpobn6pl73o5ui 36 7 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 8 Cardiovasc Cardiovasc NNP work_wgf2msbacfaetpobn6pl73o5ui 36 9 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 10 Ctr Ctr NNP work_wgf2msbacfaetpobn6pl73o5ui 36 11 . . NNP work_wgf2msbacfaetpobn6pl73o5ui 36 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 13 Suita Suita NNP work_wgf2msbacfaetpobn6pl73o5ui 36 14 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 15 Japan Japan NNP work_wgf2msbacfaetpobn6pl73o5ui 36 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 17 2Cardiac 2Cardiac NNP work_wgf2msbacfaetpobn6pl73o5ui 36 18 Physiology Physiology NNP work_wgf2msbacfaetpobn6pl73o5ui 36 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 20 Natl Natl NNP work_wgf2msbacfaetpobn6pl73o5ui 36 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 22 Cer Cer NNP work_wgf2msbacfaetpobn6pl73o5ui 36 23 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 24 Cardiovasc Cardiovasc NNP work_wgf2msbacfaetpobn6pl73o5ui 36 25 . . . work_wgf2msbacfaetpobn6pl73o5ui 36 26 CtrWakabayshi CtrWakabayshi NNP work_wgf2msbacfaetpobn6pl73o5ui 36 27 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 28 Suita Suita NNP work_wgf2msbacfaetpobn6pl73o5ui 36 29 , , , work_wgf2msbacfaetpobn6pl73o5ui 36 30 Japan Japan NNP work_wgf2msbacfaetpobn6pl73o5ui 36 31 . . . work_wgf2msbacfaetpobn6pl73o5ui 37 1 Dysregulation dysregulation NN work_wgf2msbacfaetpobn6pl73o5ui 37 2 of of IN work_wgf2msbacfaetpobn6pl73o5ui 37 3 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 37 4 homeostasis homeostasis NN work_wgf2msbacfaetpobn6pl73o5ui 37 5 in in IN work_wgf2msbacfaetpobn6pl73o5ui 37 6 cardiomyocytes cardiomyocyte NNS work_wgf2msbacfaetpobn6pl73o5ui 37 7 often often RB work_wgf2msbacfaetpobn6pl73o5ui 37 8 results result VBZ work_wgf2msbacfaetpobn6pl73o5ui 37 9 in in IN work_wgf2msbacfaetpobn6pl73o5ui 37 10 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 37 11 fail- fail- NN work_wgf2msbacfaetpobn6pl73o5ui 37 12 ure ure NN work_wgf2msbacfaetpobn6pl73o5ui 37 13 . . . work_wgf2msbacfaetpobn6pl73o5ui 38 1 Identifying identify VBG work_wgf2msbacfaetpobn6pl73o5ui 38 2 molecular molecular JJ work_wgf2msbacfaetpobn6pl73o5ui 38 3 targets target NNS work_wgf2msbacfaetpobn6pl73o5ui 38 4 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 38 5 regulate regulate VBP work_wgf2msbacfaetpobn6pl73o5ui 38 6 cardiomyocyte cardiomyocyte NN work_wgf2msbacfaetpobn6pl73o5ui 38 7 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 38 8 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 38 9 of of IN work_wgf2msbacfaetpobn6pl73o5ui 38 10 ther- ther- JJ work_wgf2msbacfaetpobn6pl73o5ui 38 11 apeutic apeutic JJ work_wgf2msbacfaetpobn6pl73o5ui 38 12 importance importance NN work_wgf2msbacfaetpobn6pl73o5ui 38 13 . . . work_wgf2msbacfaetpobn6pl73o5ui 39 1 Neuronal Neuronal NNP work_wgf2msbacfaetpobn6pl73o5ui 39 2 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 39 3 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 39 4 -sensor-1 -sensor-1 . work_wgf2msbacfaetpobn6pl73o5ui 39 5 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 39 6 NCS-1 NCS-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 39 7 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 39 8 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 39 9 an an DT work_wgf2msbacfaetpobn6pl73o5ui 39 10 EF EF NNP work_wgf2msbacfaetpobn6pl73o5ui 39 11 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 39 12 hand hand NN work_wgf2msbacfaetpobn6pl73o5ui 39 13 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 39 14 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 39 15 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 39 16 binding bind VBG work_wgf2msbacfaetpobn6pl73o5ui 39 17 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 39 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 39 19 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 39 20 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 39 21 important important JJ work_wgf2msbacfaetpobn6pl73o5ui 39 22 for for IN work_wgf2msbacfaetpobn6pl73o5ui 39 23 excitable excitable JJ work_wgf2msbacfaetpobn6pl73o5ui 39 24 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 39 25 functions function NNS work_wgf2msbacfaetpobn6pl73o5ui 39 26 . . . work_wgf2msbacfaetpobn6pl73o5ui 40 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 40 2 previously previously RB work_wgf2msbacfaetpobn6pl73o5ui 40 3 found find VBD work_wgf2msbacfaetpobn6pl73o5ui 40 4 that that IN work_wgf2msbacfaetpobn6pl73o5ui 40 5 NCS-1-deficient ncs-1-deficient NN work_wgf2msbacfaetpobn6pl73o5ui 40 6 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 40 7 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 40 8 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 40 9 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 40 10 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 40 11 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 40 12 mice mouse NNS work_wgf2msbacfaetpobn6pl73o5ui 40 13 had have VBD work_wgf2msbacfaetpobn6pl73o5ui 40 14 excess excess JJ work_wgf2msbacfaetpobn6pl73o5ui 40 15 neonatal neonatal JJ work_wgf2msbacfaetpobn6pl73o5ui 40 16 mortality mortality NN work_wgf2msbacfaetpobn6pl73o5ui 40 17 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 40 18 Circ Circ NNP work_wgf2msbacfaetpobn6pl73o5ui 40 19 . . . work_wgf2msbacfaetpobn6pl73o5ui 41 1 Res.2011).The Res.2011).The NNP work_wgf2msbacfaetpobn6pl73o5ui 41 2 aim aim VBP work_wgf2msbacfaetpobn6pl73o5ui 41 3 ofthe ofthe DT work_wgf2msbacfaetpobn6pl73o5ui 41 4 present present JJ work_wgf2msbacfaetpobn6pl73o5ui 41 5 study study NN work_wgf2msbacfaetpobn6pl73o5ui 41 6 isto isto NNP work_wgf2msbacfaetpobn6pl73o5ui 41 7 examinewhether examinewhether NNP work_wgf2msbacfaetpobn6pl73o5ui 41 8 NCS-1plays NCS-1plays NNP work_wgf2msbacfaetpobn6pl73o5ui 41 9 beneficial beneficial JJ work_wgf2msbacfaetpobn6pl73o5ui 41 10 roles role NNS work_wgf2msbacfaetpobn6pl73o5ui 41 11 in in IN work_wgf2msbacfaetpobn6pl73o5ui 41 12 cardiac cardiac JJ work_wgf2msbacfaetpobn6pl73o5ui 41 13 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 41 14 during during IN work_wgf2msbacfaetpobn6pl73o5ui 41 15 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 41 16 and and CC work_wgf2msbacfaetpobn6pl73o5ui 41 17 the the DT work_wgf2msbacfaetpobn6pl73o5ui 41 18 possible possible JJ work_wgf2msbacfaetpobn6pl73o5ui 41 19 mechanisms mechanism NNS work_wgf2msbacfaetpobn6pl73o5ui 41 20 un- un- VBP work_wgf2msbacfaetpobn6pl73o5ui 41 21 derlying derlye VBG work_wgf2msbacfaetpobn6pl73o5ui 41 22 these these DT work_wgf2msbacfaetpobn6pl73o5ui 41 23 effects effect NNS work_wgf2msbacfaetpobn6pl73o5ui 41 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 42 1 Neonatal neonatal JJ work_wgf2msbacfaetpobn6pl73o5ui 42 2 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 42 3 ventricular ventricular NN work_wgf2msbacfaetpobn6pl73o5ui 42 4 myocytes myocyte VBZ work_wgf2msbacfaetpobn6pl73o5ui 42 5 orwhole orwhole NN work_wgf2msbacfaetpobn6pl73o5ui 42 6 hearts heart NNS work_wgf2msbacfaetpobn6pl73o5ui 42 7 from from IN work_wgf2msbacfaetpobn6pl73o5ui 42 8 wild wild JJ work_wgf2msbacfaetpobn6pl73o5ui 42 9 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 42 10 type type NN work_wgf2msbacfaetpobn6pl73o5ui 42 11 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 42 12 WT WT NNP work_wgf2msbacfaetpobn6pl73o5ui 42 13 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 42 14 and and CC work_wgf2msbacfaetpobn6pl73o5ui 42 15 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 42 16 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 42 17 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 42 18 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 42 19 mice mouse NNS work_wgf2msbacfaetpobn6pl73o5ui 42 20 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 42 21 subjected subject VBN work_wgf2msbacfaetpobn6pl73o5ui 42 22 to to IN work_wgf2msbacfaetpobn6pl73o5ui 42 23 stressors stressor NNS work_wgf2msbacfaetpobn6pl73o5ui 42 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 42 25 and and CC work_wgf2msbacfaetpobn6pl73o5ui 42 26 the the DT work_wgf2msbacfaetpobn6pl73o5ui 42 27 resistance resistance NN work_wgf2msbacfaetpobn6pl73o5ui 42 28 to to IN work_wgf2msbacfaetpobn6pl73o5ui 42 29 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 42 30 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 42 31 evaluated evaluate VBN work_wgf2msbacfaetpobn6pl73o5ui 42 32 . . . work_wgf2msbacfaetpobn6pl73o5ui 43 1 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 43 2 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 43 3 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 43 4 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 43 5 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 43 6 hearts heart NNS work_wgf2msbacfaetpobn6pl73o5ui 43 7 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 43 8 more more RBR work_wgf2msbacfaetpobn6pl73o5ui 43 9 susceptible susceptible JJ work_wgf2msbacfaetpobn6pl73o5ui 43 10 to to IN work_wgf2msbacfaetpobn6pl73o5ui 43 11 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 43 12 induced induce VBN work_wgf2msbacfaetpobn6pl73o5ui 43 13 by by IN work_wgf2msbacfaetpobn6pl73o5ui 43 14 oxidative oxidative JJ work_wgf2msbacfaetpobn6pl73o5ui 43 15 impairment impairment NN work_wgf2msbacfaetpobn6pl73o5ui 43 16 and and CC work_wgf2msbacfaetpobn6pl73o5ui 43 17 ischemia ischemia NN work_wgf2msbacfaetpobn6pl73o5ui 43 18 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 43 19 reperfusion reperfusion NN work_wgf2msbacfaetpobn6pl73o5ui 43 20 injury injury NN work_wgf2msbacfaetpobn6pl73o5ui 43 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 44 1 Stress- Stress- NNP work_wgf2msbacfaetpobn6pl73o5ui 44 2 inducedactivationofphosphatidylinositol3-kinase inducedactivationofphosphatidylinositol3-kinase NNP work_wgf2msbacfaetpobn6pl73o5ui 44 3 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 44 4 PI3K)/Akt PI3K)/Akt NNP work_wgf2msbacfaetpobn6pl73o5ui 44 5 signaling signal VBG work_wgf2msbacfaetpobn6pl73o5ui 44 6 , , , work_wgf2msbacfaetpobn6pl73o5ui 44 7 a a DT work_wgf2msbacfaetpobn6pl73o5ui 44 8 major major JJ work_wgf2msbacfaetpobn6pl73o5ui 44 9 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 44 10 pathway pathway NN work_wgf2msbacfaetpobn6pl73o5ui 44 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 44 12 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 44 13 substantially substantially RB work_wgf2msbacfaetpobn6pl73o5ui 44 14 reduced reduce VBN work_wgf2msbacfaetpobn6pl73o5ui 44 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 44 16 the the DT work_wgf2msbacfaetpobn6pl73o5ui 44 17 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 44 18 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 44 19 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 44 20 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 44 21 group group NN work_wgf2msbacfaetpobn6pl73o5ui 44 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 44 23 and and CC work_wgf2msbacfaetpobn6pl73o5ui 44 24 overex- overex- JJ work_wgf2msbacfaetpobn6pl73o5ui 44 25 pressionofNCS-1 pressionofNCS-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 44 26 ortheconstitutiveactive ortheconstitutiveactive NN work_wgf2msbacfaetpobn6pl73o5ui 44 27 formofAkt formofAkt NNP work_wgf2msbacfaetpobn6pl73o5ui 44 28 increased increase VBD work_wgf2msbacfaetpobn6pl73o5ui 44 29 the the DT work_wgf2msbacfaetpobn6pl73o5ui 44 30 survivalrate survivalrate NN work_wgf2msbacfaetpobn6pl73o5ui 44 31 of of IN work_wgf2msbacfaetpobn6pl73o5ui 44 32 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 44 33 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 44 34 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 44 35 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 44 36 myocytes myocyte NNS work_wgf2msbacfaetpobn6pl73o5ui 44 37 . . . work_wgf2msbacfaetpobn6pl73o5ui 45 1 Cellular cellular JJ work_wgf2msbacfaetpobn6pl73o5ui 45 2 ATP ATP NNP work_wgf2msbacfaetpobn6pl73o5ui 45 3 levels level NNS work_wgf2msbacfaetpobn6pl73o5ui 45 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 45 5 as as RB work_wgf2msbacfaetpobn6pl73o5ui 45 6 well well RB work_wgf2msbacfaetpobn6pl73o5ui 45 7 as as IN work_wgf2msbacfaetpobn6pl73o5ui 45 8 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 45 9 respiration respiration NN work_wgf2msbacfaetpobn6pl73o5ui 45 10 rates rate NNS work_wgf2msbacfaetpobn6pl73o5ui 45 11 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 45 12 both both CC work_wgf2msbacfaetpobn6pl73o5ui 45 13 basal basal NN work_wgf2msbacfaetpobn6pl73o5ui 45 14 and and CC work_wgf2msbacfaetpobn6pl73o5ui 45 15 maximal maximal NNP work_wgf2msbacfaetpobn6pl73o5ui 45 16 O2 O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 45 17 consumption consumption NN work_wgf2msbacfaetpobn6pl73o5ui 45 18 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 45 19 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 45 20 significantly significantly RB work_wgf2msbacfaetpobn6pl73o5ui 45 21 depressed depress VBN work_wgf2msbacfaetpobn6pl73o5ui 45 22 in in IN work_wgf2msbacfaetpobn6pl73o5ui 45 23 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 45 24 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 45 25 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 45 26 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 45 27 myocytes myocyte VBZ work_wgf2msbacfaetpobn6pl73o5ui 45 28 ; ; : work_wgf2msbacfaetpobn6pl73o5ui 45 29 especially especially RB work_wgf2msbacfaetpobn6pl73o5ui 45 30 with with IN work_wgf2msbacfaetpobn6pl73o5ui 45 31 oxidative oxidative JJ work_wgf2msbacfaetpobn6pl73o5ui 45 32 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 45 33 . . . work_wgf2msbacfaetpobn6pl73o5ui 46 1 Furthermore furthermore RB work_wgf2msbacfaetpobn6pl73o5ui 46 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 46 3 intracellular intracellular JJ work_wgf2msbacfaetpobn6pl73o5ui 46 4 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 46 5 handling handling NN work_wgf2msbacfaetpobn6pl73o5ui 46 6 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 46 7 more more RBR work_wgf2msbacfaetpobn6pl73o5ui 46 8 easily easily RB work_wgf2msbacfaetpobn6pl73o5ui 46 9 dysregulated dysregulate VBN work_wgf2msbacfaetpobn6pl73o5ui 46 10 in in IN work_wgf2msbacfaetpobn6pl73o5ui 46 11 stressed stressed JJ work_wgf2msbacfaetpobn6pl73o5ui 46 12 Ncs1 Ncs1 NNP work_wgf2msbacfaetpobn6pl73o5ui 46 13 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 46 14 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 46 15 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 46 16 myocytes myocyte NNS work_wgf2msbacfaetpobn6pl73o5ui 46 17 than than IN work_wgf2msbacfaetpobn6pl73o5ui 46 18 WT WT NNP work_wgf2msbacfaetpobn6pl73o5ui 46 19 myocytes myocytes NNP work_wgf2msbacfaetpobn6pl73o5ui 46 20 . . . work_wgf2msbacfaetpobn6pl73o5ui 47 1 Since since IN work_wgf2msbacfaetpobn6pl73o5ui 47 2 NCS-1 NCS-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 47 3 levels level NNS work_wgf2msbacfaetpobn6pl73o5ui 47 4 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 47 5 increased increase VBN work_wgf2msbacfaetpobn6pl73o5ui 47 6 by by IN work_wgf2msbacfaetpobn6pl73o5ui 47 7 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 47 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 47 9 the the DT work_wgf2msbacfaetpobn6pl73o5ui 47 10 data datum NNS work_wgf2msbacfaetpobn6pl73o5ui 47 11 suggest suggest VBP work_wgf2msbacfaetpobn6pl73o5ui 47 12 that that IN work_wgf2msbacfaetpobn6pl73o5ui 47 13 NCS-1 NCS-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 47 14 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 47 15 a a DT work_wgf2msbacfaetpobn6pl73o5ui 47 16 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 47 17 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 47 18 promoting promote VBG work_wgf2msbacfaetpobn6pl73o5ui 47 19 factor factor NN work_wgf2msbacfaetpobn6pl73o5ui 47 20 , , , work_wgf2msbacfaetpobn6pl73o5ui 47 21 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 47 22 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 47 23 upregulated upregulate VBN work_wgf2msbacfaetpobn6pl73o5ui 47 24 by by IN work_wgf2msbacfaetpobn6pl73o5ui 47 25 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 47 26 stimuli stimulus NNS work_wgf2msbacfaetpobn6pl73o5ui 47 27 . . . work_wgf2msbacfaetpobn6pl73o5ui 48 1 Interestingly interestingly RB work_wgf2msbacfaetpobn6pl73o5ui 48 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 48 3 however however RB work_wgf2msbacfaetpobn6pl73o5ui 48 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 48 5 supra supra NN work_wgf2msbacfaetpobn6pl73o5ui 48 6 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 48 7 physiological physiological JJ work_wgf2msbacfaetpobn6pl73o5ui 48 8 NCS-1 NCS-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 48 9 expression expression NN work_wgf2msbacfaetpobn6pl73o5ui 48 10 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 48 11 toxic toxic JJ work_wgf2msbacfaetpobn6pl73o5ui 48 12 to to IN work_wgf2msbacfaetpobn6pl73o5ui 48 13 cells cell NNS work_wgf2msbacfaetpobn6pl73o5ui 48 14 . . . work_wgf2msbacfaetpobn6pl73o5ui 49 1 Taken take VBN work_wgf2msbacfaetpobn6pl73o5ui 49 2 together together RB work_wgf2msbacfaetpobn6pl73o5ui 49 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 49 4 our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 49 5 data datum NNS work_wgf2msbacfaetpobn6pl73o5ui 49 6 suggest suggest VBP work_wgf2msbacfaetpobn6pl73o5ui 49 7 that that IN work_wgf2msbacfaetpobn6pl73o5ui 49 8 moderate moderate JJ work_wgf2msbacfaetpobn6pl73o5ui 49 9 NCS-1 NCS-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 49 10 expression expression NN work_wgf2msbacfaetpobn6pl73o5ui 49 11 during during IN work_wgf2msbacfaetpobn6pl73o5ui 49 12 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 49 13 promotes promote VBZ work_wgf2msbacfaetpobn6pl73o5ui 49 14 cardiomyocyte cardiomyocyte JJ work_wgf2msbacfaetpobn6pl73o5ui 49 15 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 49 16 by by IN work_wgf2msbacfaetpobn6pl73o5ui 49 17 maintaining maintain VBG work_wgf2msbacfaetpobn6pl73o5ui 49 18 proper proper JJ work_wgf2msbacfaetpobn6pl73o5ui 49 19 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 49 20 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 49 21 handling handling NN work_wgf2msbacfaetpobn6pl73o5ui 49 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 49 23 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 49 24 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 49 25 required require VBN work_wgf2msbacfaetpobn6pl73o5ui 49 26 for for IN work_wgf2msbacfaetpobn6pl73o5ui 49 27 activation activation NN work_wgf2msbacfaetpobn6pl73o5ui 49 28 of of IN work_wgf2msbacfaetpobn6pl73o5ui 49 29 Akt Akt NNP work_wgf2msbacfaetpobn6pl73o5ui 49 30 survival survival NN work_wgf2msbacfaetpobn6pl73o5ui 49 31 pathways pathway NNS work_wgf2msbacfaetpobn6pl73o5ui 49 32 and and CC work_wgf2msbacfaetpobn6pl73o5ui 49 33 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 49 34 function function NN work_wgf2msbacfaetpobn6pl73o5ui 49 35 . . . work_wgf2msbacfaetpobn6pl73o5ui 50 1 3074-Pos 3074-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 50 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 50 3 B504 B504 NNP work_wgf2msbacfaetpobn6pl73o5ui 50 4 Initiation Initiation NNP work_wgf2msbacfaetpobn6pl73o5ui 50 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 50 6 Electron Electron NNP work_wgf2msbacfaetpobn6pl73o5ui 50 7 Transport Transport NNP work_wgf2msbacfaetpobn6pl73o5ui 50 8 Activity Activity NNP work_wgf2msbacfaetpobn6pl73o5ui 50 9 and and CC work_wgf2msbacfaetpobn6pl73o5ui 50 10 a a DT work_wgf2msbacfaetpobn6pl73o5ui 50 11 Decrease Decrease NNP work_wgf2msbacfaetpobn6pl73o5ui 50 12 of of IN work_wgf2msbacfaetpobn6pl73o5ui 50 13 Oxidative Oxidative NNP work_wgf2msbacfaetpobn6pl73o5ui 50 14 Stress Stress NNP work_wgf2msbacfaetpobn6pl73o5ui 50 15 Occur occur VB work_wgf2msbacfaetpobn6pl73o5ui 50 16 Simultaneously simultaneously RB work_wgf2msbacfaetpobn6pl73o5ui 50 17 during during IN work_wgf2msbacfaetpobn6pl73o5ui 50 18 Embryonic Embryonic NNP work_wgf2msbacfaetpobn6pl73o5ui 50 19 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 50 20 Development Development NNP work_wgf2msbacfaetpobn6pl73o5ui 50 21 Gisela Gisela NNP work_wgf2msbacfaetpobn6pl73o5ui 50 22 Beutner Beutner NNP work_wgf2msbacfaetpobn6pl73o5ui 50 23 , , , work_wgf2msbacfaetpobn6pl73o5ui 50 24 George George NNP work_wgf2msbacfaetpobn6pl73o5ui 50 25 A. A. NNP work_wgf2msbacfaetpobn6pl73o5ui 50 26 Porter Porter NNP work_wgf2msbacfaetpobn6pl73o5ui 50 27 , , , work_wgf2msbacfaetpobn6pl73o5ui 50 28 Jr. Jr. NNP work_wgf2msbacfaetpobn6pl73o5ui 50 29 Pediatrics Pediatrics NNP work_wgf2msbacfaetpobn6pl73o5ui 50 30 , , , work_wgf2msbacfaetpobn6pl73o5ui 50 31 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 50 32 of of IN work_wgf2msbacfaetpobn6pl73o5ui 50 33 Rochester Rochester NNP work_wgf2msbacfaetpobn6pl73o5ui 50 34 Medical Medical NNP work_wgf2msbacfaetpobn6pl73o5ui 50 35 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 50 36 , , , work_wgf2msbacfaetpobn6pl73o5ui 50 37 Rochester Rochester NNP work_wgf2msbacfaetpobn6pl73o5ui 50 38 , , , work_wgf2msbacfaetpobn6pl73o5ui 50 39 NY NY NNP work_wgf2msbacfaetpobn6pl73o5ui 50 40 , , , work_wgf2msbacfaetpobn6pl73o5ui 50 41 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 50 42 . . . work_wgf2msbacfaetpobn6pl73o5ui 51 1 Mitochondria Mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 51 2 in in IN work_wgf2msbacfaetpobn6pl73o5ui 51 3 early early JJ work_wgf2msbacfaetpobn6pl73o5ui 51 4 embryonic embryonic JJ work_wgf2msbacfaetpobn6pl73o5ui 51 5 hearts heart NNS work_wgf2msbacfaetpobn6pl73o5ui 51 6 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 51 7 not not RB work_wgf2msbacfaetpobn6pl73o5ui 51 8 thought think VBN work_wgf2msbacfaetpobn6pl73o5ui 51 9 to to TO work_wgf2msbacfaetpobn6pl73o5ui 51 10 produce produce VB work_wgf2msbacfaetpobn6pl73o5ui 51 11 ATP ATP NNP work_wgf2msbacfaetpobn6pl73o5ui 51 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 51 13 yet yet CC work_wgf2msbacfaetpobn6pl73o5ui 51 14 they -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 51 15 do do VBP work_wgf2msbacfaetpobn6pl73o5ui 51 16 produce produce VB work_wgf2msbacfaetpobn6pl73o5ui 51 17 reactive reactive JJ work_wgf2msbacfaetpobn6pl73o5ui 51 18 oxygen oxygen NN work_wgf2msbacfaetpobn6pl73o5ui 51 19 species specie NNS work_wgf2msbacfaetpobn6pl73o5ui 51 20 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 51 21 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 51 22 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 51 23 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 51 24 regulate regulate VBP work_wgf2msbacfaetpobn6pl73o5ui 51 25 myocyte myocyte NNP work_wgf2msbacfaetpobn6pl73o5ui 51 26 differen- differen- NNP work_wgf2msbacfaetpobn6pl73o5ui 51 27 tiation tiation NN work_wgf2msbacfaetpobn6pl73o5ui 51 28 . . . work_wgf2msbacfaetpobn6pl73o5ui 52 1 To to TO work_wgf2msbacfaetpobn6pl73o5ui 52 2 assess assess VB work_wgf2msbacfaetpobn6pl73o5ui 52 3 changes change NNS work_wgf2msbacfaetpobn6pl73o5ui 52 4 in in IN work_wgf2msbacfaetpobn6pl73o5ui 52 5 ATP atp NN work_wgf2msbacfaetpobn6pl73o5ui 52 6 and and CC work_wgf2msbacfaetpobn6pl73o5ui 52 7 ROS ros NN work_wgf2msbacfaetpobn6pl73o5ui 52 8 generation generation NN work_wgf2msbacfaetpobn6pl73o5ui 52 9 in in IN work_wgf2msbacfaetpobn6pl73o5ui 52 10 the the DT work_wgf2msbacfaetpobn6pl73o5ui 52 11 developing develop VBG work_wgf2msbacfaetpobn6pl73o5ui 52 12 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 52 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 52 14 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 52 15 measured measure VBD work_wgf2msbacfaetpobn6pl73o5ui 52 16 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 52 17 oxygen oxygen NN work_wgf2msbacfaetpobn6pl73o5ui 52 18 consumption consumption NN work_wgf2msbacfaetpobn6pl73o5ui 52 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 52 20 the the DT work_wgf2msbacfaetpobn6pl73o5ui 52 21 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 52 22 of of IN work_wgf2msbacfaetpobn6pl73o5ui 52 23 the the DT work_wgf2msbacfaetpobn6pl73o5ui 52 24 complexes complex NNS work_wgf2msbacfaetpobn6pl73o5ui 52 25 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 52 26 Cx Cx NNP work_wgf2msbacfaetpobn6pl73o5ui 52 27 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 52 28 1 1 CD work_wgf2msbacfaetpobn6pl73o5ui 52 29 and and CC work_wgf2msbacfaetpobn6pl73o5ui 52 30 2 2 CD work_wgf2msbacfaetpobn6pl73o5ui 52 31 of of IN work_wgf2msbacfaetpobn6pl73o5ui 52 32 the the DT work_wgf2msbacfaetpobn6pl73o5ui 52 33 electron electron NNP work_wgf2msbacfaetpobn6pl73o5ui 52 34 transport transport NN work_wgf2msbacfaetpobn6pl73o5ui 52 35 chain chain NN work_wgf2msbacfaetpobn6pl73o5ui 52 36 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 52 37 ETC ETC NNP work_wgf2msbacfaetpobn6pl73o5ui 52 38 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 52 39 , , , work_wgf2msbacfaetpobn6pl73o5ui 52 40 ETC etc FW work_wgf2msbacfaetpobn6pl73o5ui 52 41 supercomplex supercomplex NN work_wgf2msbacfaetpobn6pl73o5ui 52 42 assem- assem- RB work_wgf2msbacfaetpobn6pl73o5ui 52 43 bly bly RB work_wgf2msbacfaetpobn6pl73o5ui 52 44 , , , work_wgf2msbacfaetpobn6pl73o5ui 52 45 and and CC work_wgf2msbacfaetpobn6pl73o5ui 52 46 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 52 47 in in IN work_wgf2msbacfaetpobn6pl73o5ui 52 48 embryonic embryonic JJ work_wgf2msbacfaetpobn6pl73o5ui 52 49 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 52 50 hearts heart NNS work_wgf2msbacfaetpobn6pl73o5ui 52 51 . . . work_wgf2msbacfaetpobn6pl73o5ui 53 1 At at IN work_wgf2msbacfaetpobn6pl73o5ui 53 2 embryonic embryonic JJ work_wgf2msbacfaetpobn6pl73o5ui 53 3 day day NN work_wgf2msbacfaetpobn6pl73o5ui 53 4 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 53 5 E e NN work_wgf2msbacfaetpobn6pl73o5ui 53 6 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 53 7 9.5 9.5 CD work_wgf2msbacfaetpobn6pl73o5ui 53 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 53 9 mitochon- mitochon- FW work_wgf2msbacfaetpobn6pl73o5ui 53 10 drial drial FW work_wgf2msbacfaetpobn6pl73o5ui 53 11 ETC ETC NNP work_wgf2msbacfaetpobn6pl73o5ui 53 12 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 53 13 and and CC work_wgf2msbacfaetpobn6pl73o5ui 53 14 oxidative oxidative JJ work_wgf2msbacfaetpobn6pl73o5ui 53 15 phosphorylation phosphorylation NN work_wgf2msbacfaetpobn6pl73o5ui 53 16 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 53 17 OXPHOS OXPHOS NNP work_wgf2msbacfaetpobn6pl73o5ui 53 18 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 53 19 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 53 20 not not RB work_wgf2msbacfaetpobn6pl73o5ui 53 21 coupled couple VBN work_wgf2msbacfaetpobn6pl73o5ui 53 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 53 23 even even RB work_wgf2msbacfaetpobn6pl73o5ui 53 24 though though IN work_wgf2msbacfaetpobn6pl73o5ui 53 25 the the DT work_wgf2msbacfaetpobn6pl73o5ui 53 26 ETC ETC NNP work_wgf2msbacfaetpobn6pl73o5ui 53 27 complexes complex NNS work_wgf2msbacfaetpobn6pl73o5ui 53 28 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 53 29 present present JJ work_wgf2msbacfaetpobn6pl73o5ui 53 30 . . . work_wgf2msbacfaetpobn6pl73o5ui 54 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 54 2 show show VBP work_wgf2msbacfaetpobn6pl73o5ui 54 3 that that IN work_wgf2msbacfaetpobn6pl73o5ui 54 4 Cx-1 Cx-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 54 5 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 54 6 able able JJ work_wgf2msbacfaetpobn6pl73o5ui 54 7 to to TO work_wgf2msbacfaetpobn6pl73o5ui 54 8 accept accept VB work_wgf2msbacfaetpobn6pl73o5ui 54 9 electrons electron NNS work_wgf2msbacfaetpobn6pl73o5ui 54 10 from from IN work_wgf2msbacfaetpobn6pl73o5ui 54 11 the the DT work_wgf2msbacfaetpobn6pl73o5ui 54 12 Krebs Krebs NNP work_wgf2msbacfaetpobn6pl73o5ui 54 13 cycle cycle NN work_wgf2msbacfaetpobn6pl73o5ui 54 14 , , , work_wgf2msbacfaetpobn6pl73o5ui 54 15 but but CC work_wgf2msbacfaetpobn6pl73o5ui 54 16 enzyme enzyme VBZ work_wgf2msbacfaetpobn6pl73o5ui 54 17 assays assays RB work_wgf2msbacfaetpobn6pl73o5ui 54 18 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 54 19 specifically specifically RB work_wgf2msbacfaetpobn6pl73o5ui 54 20 mea- mea- VBZ work_wgf2msbacfaetpobn6pl73o5ui 54 21 sure sure JJ work_wgf2msbacfaetpobn6pl73o5ui 54 22 electron electron NN work_wgf2msbacfaetpobn6pl73o5ui 54 23 flow flow NN work_wgf2msbacfaetpobn6pl73o5ui 54 24 to to IN work_wgf2msbacfaetpobn6pl73o5ui 54 25 ubiquinone ubiquinone NNP work_wgf2msbacfaetpobn6pl73o5ui 54 26 or or CC work_wgf2msbacfaetpobn6pl73o5ui 54 27 Cx-3 Cx-3 NNP work_wgf2msbacfaetpobn6pl73o5ui 54 28 show show VB work_wgf2msbacfaetpobn6pl73o5ui 54 29 no no DT work_wgf2msbacfaetpobn6pl73o5ui 54 30 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 54 31 at at IN work_wgf2msbacfaetpobn6pl73o5ui 54 32 this this DT work_wgf2msbacfaetpobn6pl73o5ui 54 33 early early JJ work_wgf2msbacfaetpobn6pl73o5ui 54 34 embry- embry- JJ work_wgf2msbacfaetpobn6pl73o5ui 54 35 onic onic JJ work_wgf2msbacfaetpobn6pl73o5ui 54 36 stage stage NN work_wgf2msbacfaetpobn6pl73o5ui 54 37 . . . work_wgf2msbacfaetpobn6pl73o5ui 55 1 At at IN work_wgf2msbacfaetpobn6pl73o5ui 55 2 E11.5 e11.5 RB work_wgf2msbacfaetpobn6pl73o5ui 55 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 55 4 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 55 5 appear appear VBP work_wgf2msbacfaetpobn6pl73o5ui 55 6 functionally functionally RB work_wgf2msbacfaetpobn6pl73o5ui 55 7 more more RBR work_wgf2msbacfaetpobn6pl73o5ui 55 8 mature mature JJ work_wgf2msbacfaetpobn6pl73o5ui 55 9 ; ; : work_wgf2msbacfaetpobn6pl73o5ui 55 10 ETC etc NN work_wgf2msbacfaetpobn6pl73o5ui 55 11 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 55 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 55 13 OXPHOS OXPHOS NNP work_wgf2msbacfaetpobn6pl73o5ui 55 14 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 55 15 coupled couple VBN work_wgf2msbacfaetpobn6pl73o5ui 55 16 and and CC work_wgf2msbacfaetpobn6pl73o5ui 55 17 respond respond VB work_wgf2msbacfaetpobn6pl73o5ui 55 18 to to IN work_wgf2msbacfaetpobn6pl73o5ui 55 19 ETC ETC NNP work_wgf2msbacfaetpobn6pl73o5ui 55 20 inhibitors inhibitor NNS work_wgf2msbacfaetpobn6pl73o5ui 55 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 56 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 56 2 addition addition NN work_wgf2msbacfaetpobn6pl73o5ui 56 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 56 4 the the DT work_wgf2msbacfaetpobn6pl73o5ui 56 5 assembly assembly NN work_wgf2msbacfaetpobn6pl73o5ui 56 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 56 7 highly highly RB work_wgf2msbacfaetpobn6pl73o5ui 56 8 efficient efficient JJ work_wgf2msbacfaetpobn6pl73o5ui 56 9 respiratory respiratory JJ work_wgf2msbacfaetpobn6pl73o5ui 56 10 supercomplexes supercomplexe NNS work_wgf2msbacfaetpobn6pl73o5ui 56 11 containing contain VBG work_wgf2msbacfaetpobn6pl73o5ui 56 12 Cx Cx NNP work_wgf2msbacfaetpobn6pl73o5ui 56 13 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 56 14 1 1 CD work_wgf2msbacfaetpobn6pl73o5ui 56 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 56 16 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 56 17 3 3 CD work_wgf2msbacfaetpobn6pl73o5ui 56 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 56 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 56 20 � � NNP work_wgf2msbacfaetpobn6pl73o5ui 56 21 4 4 CD work_wgf2msbacfaetpobn6pl73o5ui 56 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 56 23 ubiquinone ubiquinone RB work_wgf2msbacfaetpobn6pl73o5ui 56 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 56 25 and and CC work_wgf2msbacfaetpobn6pl73o5ui 56 26 cytochrome cytochrome DT work_wgf2msbacfaetpobn6pl73o5ui 56 27 c c NN work_wgf2msbacfaetpobn6pl73o5ui 56 28 begins begin VBZ work_wgf2msbacfaetpobn6pl73o5ui 56 29 at at IN work_wgf2msbacfaetpobn6pl73o5ui 56 30 E11.5 e11.5 NN work_wgf2msbacfaetpobn6pl73o5ui 56 31 , , , work_wgf2msbacfaetpobn6pl73o5ui 56 32 the the DT work_wgf2msbacfaetpobn6pl73o5ui 56 33 exact exact JJ work_wgf2msbacfaetpobn6pl73o5ui 56 34 time time NN work_wgf2msbacfaetpobn6pl73o5ui 56 35 when when WRB work_wgf2msbacfaetpobn6pl73o5ui 56 36 Cx-1 Cx-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 56 37 becomes become VBZ work_wgf2msbacfaetpobn6pl73o5ui 56 38 functional functional JJ work_wgf2msbacfaetpobn6pl73o5ui 56 39 activated activate VBN work_wgf2msbacfaetpobn6pl73o5ui 56 40 . . . work_wgf2msbacfaetpobn6pl73o5ui 57 1 At at IN work_wgf2msbacfaetpobn6pl73o5ui 57 2 E13.5 e13.5 RB work_wgf2msbacfaetpobn6pl73o5ui 57 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 57 4 ETC etc NN work_wgf2msbacfaetpobn6pl73o5ui 57 5 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 57 6 and and CC work_wgf2msbacfaetpobn6pl73o5ui 57 7 OXPHOS OXPHOS NNP work_wgf2msbacfaetpobn6pl73o5ui 57 8 of of IN work_wgf2msbacfaetpobn6pl73o5ui 57 9 embryonic embryonic JJ work_wgf2msbacfaetpobn6pl73o5ui 57 10 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 57 11 mitochondria mitochondrion NNS work_wgf2msbacfaetpobn6pl73o5ui 57 12 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 57 13 indistinguishable indistinguishable JJ work_wgf2msbacfaetpobn6pl73o5ui 57 14 from from IN work_wgf2msbacfaetpobn6pl73o5ui 57 15 adult adult NN work_wgf2msbacfaetpobn6pl73o5ui 57 16 mitochon- mitochon- NNP work_wgf2msbacfaetpobn6pl73o5ui 57 17 dria dria NN work_wgf2msbacfaetpobn6pl73o5ui 57 18 . . . work_wgf2msbacfaetpobn6pl73o5ui 58 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 58 2 contrast contrast NN work_wgf2msbacfaetpobn6pl73o5ui 58 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 58 4 generation generation NN work_wgf2msbacfaetpobn6pl73o5ui 58 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 58 6 reactive reactive JJ work_wgf2msbacfaetpobn6pl73o5ui 58 7 oxygen oxygen NN work_wgf2msbacfaetpobn6pl73o5ui 58 8 species specie NNS work_wgf2msbacfaetpobn6pl73o5ui 58 9 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 58 10 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 58 11 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 58 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 58 13 as as IN work_wgf2msbacfaetpobn6pl73o5ui 58 14 measured measure VBN work_wgf2msbacfaetpobn6pl73o5ui 58 15 with with IN work_wgf2msbacfaetpobn6pl73o5ui 58 16 Amplex Amplex NNP work_wgf2msbacfaetpobn6pl73o5ui 58 17 Red Red NNP work_wgf2msbacfaetpobn6pl73o5ui 58 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 58 19 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 58 20 high high JJ work_wgf2msbacfaetpobn6pl73o5ui 58 21 at at IN work_wgf2msbacfaetpobn6pl73o5ui 58 22 E9.5 E9.5 NNP work_wgf2msbacfaetpobn6pl73o5ui 58 23 and and CC work_wgf2msbacfaetpobn6pl73o5ui 58 24 drops drop VBZ work_wgf2msbacfaetpobn6pl73o5ui 58 25 significantly significantly RB work_wgf2msbacfaetpobn6pl73o5ui 58 26 by by IN work_wgf2msbacfaetpobn6pl73o5ui 58 27 E11.5 e11.5 XX work_wgf2msbacfaetpobn6pl73o5ui 58 28 , , , work_wgf2msbacfaetpobn6pl73o5ui 58 29 coinciding coincide VBG work_wgf2msbacfaetpobn6pl73o5ui 58 30 with with IN work_wgf2msbacfaetpobn6pl73o5ui 58 31 activation activation NN work_wgf2msbacfaetpobn6pl73o5ui 58 32 of of IN work_wgf2msbacfaetpobn6pl73o5ui 58 33 the the DT work_wgf2msbacfaetpobn6pl73o5ui 58 34 ETC ETC NNP work_wgf2msbacfaetpobn6pl73o5ui 58 35 . . . work_wgf2msbacfaetpobn6pl73o5ui 59 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 59 2 summary summary NN work_wgf2msbacfaetpobn6pl73o5ui 59 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 59 4 our -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 59 5 data datum NNS work_wgf2msbacfaetpobn6pl73o5ui 59 6 suggest suggest VBP work_wgf2msbacfaetpobn6pl73o5ui 59 7 that that IN work_wgf2msbacfaetpobn6pl73o5ui 59 8 between between IN work_wgf2msbacfaetpobn6pl73o5ui 59 9 E9.5 E9.5 NNP work_wgf2msbacfaetpobn6pl73o5ui 59 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 59 11 E11.5 e11.5 FW work_wgf2msbacfaetpobn6pl73o5ui 59 12 dramatic dramatic JJ work_wgf2msbacfaetpobn6pl73o5ui 59 13 changes change NNS work_wgf2msbacfaetpobn6pl73o5ui 59 14 occur occur VBP work_wgf2msbacfaetpobn6pl73o5ui 59 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 59 16 the the DT work_wgf2msbacfaetpobn6pl73o5ui 59 17 mitochondria mitochondria NN work_wgf2msbacfaetpobn6pl73o5ui 59 18 of of IN work_wgf2msbacfaetpobn6pl73o5ui 59 19 the the DT work_wgf2msbacfaetpobn6pl73o5ui 59 20 embryonic embryonic JJ work_wgf2msbacfaetpobn6pl73o5ui 59 21 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 59 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 59 23 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 59 24 result result VBP work_wgf2msbacfaetpobn6pl73o5ui 59 25 in in IN work_wgf2msbacfaetpobn6pl73o5ui 59 26 a a DT work_wgf2msbacfaetpobn6pl73o5ui 59 27 decrease decrease NN work_wgf2msbacfaetpobn6pl73o5ui 59 28 of of IN work_wgf2msbacfaetpobn6pl73o5ui 59 29 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 59 30 generation generation NN work_wgf2msbacfaetpobn6pl73o5ui 59 31 and and CC work_wgf2msbacfaetpobn6pl73o5ui 59 32 an an DT work_wgf2msbacfaetpobn6pl73o5ui 59 33 increase increase NN work_wgf2msbacfaetpobn6pl73o5ui 59 34 in in IN work_wgf2msbacfaetpobn6pl73o5ui 59 35 OXPHOS OXPHOS NNP work_wgf2msbacfaetpobn6pl73o5ui 59 36 due due IN work_wgf2msbacfaetpobn6pl73o5ui 59 37 to to IN work_wgf2msbacfaetpobn6pl73o5ui 59 38 the the DT work_wgf2msbacfaetpobn6pl73o5ui 59 39 activation activation NN work_wgf2msbacfaetpobn6pl73o5ui 59 40 of of IN work_wgf2msbacfaetpobn6pl73o5ui 59 41 Cx-1 Cx-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 59 42 and and CC work_wgf2msbacfaetpobn6pl73o5ui 59 43 the the DT work_wgf2msbacfaetpobn6pl73o5ui 59 44 formation formation NN work_wgf2msbacfaetpobn6pl73o5ui 59 45 of of IN work_wgf2msbacfaetpobn6pl73o5ui 59 46 supercomplexes supercomplexe NNS work_wgf2msbacfaetpobn6pl73o5ui 59 47 . . . work_wgf2msbacfaetpobn6pl73o5ui 60 1 3075-Pos 3075-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 60 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 60 3 B505 B505 NNP work_wgf2msbacfaetpobn6pl73o5ui 60 4 The the DT work_wgf2msbacfaetpobn6pl73o5ui 60 5 Stoichiometry Stoichiometry NNP work_wgf2msbacfaetpobn6pl73o5ui 60 6 between between IN work_wgf2msbacfaetpobn6pl73o5ui 60 7 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 60 8 and and CC work_wgf2msbacfaetpobn6pl73o5ui 60 9 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 60 10 Determines determine VBZ work_wgf2msbacfaetpobn6pl73o5ui 60 11 the the DT work_wgf2msbacfaetpobn6pl73o5ui 60 12 Different Different NNP work_wgf2msbacfaetpobn6pl73o5ui 60 13 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 60 14 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 60 15 2D 2d VB work_wgf2msbacfaetpobn6pl73o5ui 60 16 Uptake Uptake NNP work_wgf2msbacfaetpobn6pl73o5ui 60 17 Phenotypes Phenotypes NNP work_wgf2msbacfaetpobn6pl73o5ui 60 18 in in IN work_wgf2msbacfaetpobn6pl73o5ui 60 19 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 60 20 and and CC work_wgf2msbacfaetpobn6pl73o5ui 60 21 Liver Liver NNP work_wgf2msbacfaetpobn6pl73o5ui 60 22 Melanie Melanie NNP work_wgf2msbacfaetpobn6pl73o5ui 60 23 Paillard Paillard NNP work_wgf2msbacfaetpobn6pl73o5ui 60 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 60 25 György György NNP work_wgf2msbacfaetpobn6pl73o5ui 60 26 Csordás Csordás NNP work_wgf2msbacfaetpobn6pl73o5ui 60 27 , , , work_wgf2msbacfaetpobn6pl73o5ui 60 28 Tünde Tünde NNP work_wgf2msbacfaetpobn6pl73o5ui 60 29 Golenár Golenár NNP work_wgf2msbacfaetpobn6pl73o5ui 60 30 , , , work_wgf2msbacfaetpobn6pl73o5ui 60 31 Cynthia Cynthia NNP work_wgf2msbacfaetpobn6pl73o5ui 60 32 Moffat Moffat NNP work_wgf2msbacfaetpobn6pl73o5ui 60 33 , , , work_wgf2msbacfaetpobn6pl73o5ui 60 34 Erin Erin NNP work_wgf2msbacfaetpobn6pl73o5ui 60 35 Seifert Seifert NNP work_wgf2msbacfaetpobn6pl73o5ui 60 36 , , , work_wgf2msbacfaetpobn6pl73o5ui 60 37 György György NNP work_wgf2msbacfaetpobn6pl73o5ui 60 38 Hajnóczky Hajnóczky NNP work_wgf2msbacfaetpobn6pl73o5ui 60 39 . . . work_wgf2msbacfaetpobn6pl73o5ui 61 1 MitoCare MitoCare NNP work_wgf2msbacfaetpobn6pl73o5ui 61 2 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 61 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 61 4 Pathology Pathology NNP work_wgf2msbacfaetpobn6pl73o5ui 61 5 , , , work_wgf2msbacfaetpobn6pl73o5ui 61 6 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 61 7 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 61 8 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 61 9 , , , work_wgf2msbacfaetpobn6pl73o5ui 61 10 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 61 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 61 12 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 61 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 61 14 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 61 15 . . . work_wgf2msbacfaetpobn6pl73o5ui 62 1 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 62 2 Ca2þ Ca2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 62 3 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 62 4 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 62 5 central central JJ work_wgf2msbacfaetpobn6pl73o5ui 62 6 to to IN work_wgf2msbacfaetpobn6pl73o5ui 62 7 oxidative oxidative JJ work_wgf2msbacfaetpobn6pl73o5ui 62 8 metabolism metabolism NN work_wgf2msbacfaetpobn6pl73o5ui 62 9 and and CC work_wgf2msbacfaetpobn6pl73o5ui 62 10 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 62 11 death death NN work_wgf2msbacfaetpobn6pl73o5ui 62 12 signaling signaling NN work_wgf2msbacfaetpobn6pl73o5ui 62 13 . . . work_wgf2msbacfaetpobn6pl73o5ui 63 1 The the DT work_wgf2msbacfaetpobn6pl73o5ui 63 2 first first JJ work_wgf2msbacfaetpobn6pl73o5ui 63 3 clues clue NNS work_wgf2msbacfaetpobn6pl73o5ui 63 4 to to IN work_wgf2msbacfaetpobn6pl73o5ui 63 5 its -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 63 6 molecular molecular JJ work_wgf2msbacfaetpobn6pl73o5ui 63 7 mechanism mechanism NN work_wgf2msbacfaetpobn6pl73o5ui 63 8 have have VBP work_wgf2msbacfaetpobn6pl73o5ui 63 9 emerged emerge VBN work_wgf2msbacfaetpobn6pl73o5ui 63 10 from from IN work_wgf2msbacfaetpobn6pl73o5ui 63 11 the the DT work_wgf2msbacfaetpobn6pl73o5ui 63 12 recent recent JJ work_wgf2msbacfaetpobn6pl73o5ui 63 13 identification identification NN work_wgf2msbacfaetpobn6pl73o5ui 63 14 of of IN work_wgf2msbacfaetpobn6pl73o5ui 63 15 the the DT work_wgf2msbacfaetpobn6pl73o5ui 63 16 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 63 17 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 63 18 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 63 19 uniporter uniporter NN work_wgf2msbacfaetpobn6pl73o5ui 63 20 ’s ’s POS work_wgf2msbacfaetpobn6pl73o5ui 63 21 pore pore NN work_wgf2msbacfaetpobn6pl73o5ui 63 22 forming form VBG work_wgf2msbacfaetpobn6pl73o5ui 63 23 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 63 24 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 63 25 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 63 26 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 63 27 as as RB work_wgf2msbacfaetpobn6pl73o5ui 63 28 well well RB work_wgf2msbacfaetpobn6pl73o5ui 63 29 as as IN work_wgf2msbacfaetpobn6pl73o5ui 63 30 its -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 63 31 regulators regulator NNS work_wgf2msbacfaetpobn6pl73o5ui 63 32 . . . work_wgf2msbacfaetpobn6pl73o5ui 64 1 Among among IN work_wgf2msbacfaetpobn6pl73o5ui 64 2 the the DT work_wgf2msbacfaetpobn6pl73o5ui 64 3 regulators regulator NNS work_wgf2msbacfaetpobn6pl73o5ui 64 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 64 5 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 64 6 shows show NNS work_wgf2msbacfaetpobn6pl73o5ui 64 7 striking striking JJ work_wgf2msbacfaetpobn6pl73o5ui 64 8 610a 610a NNPS work_wgf2msbacfaetpobn6pl73o5ui 64 9 Wednesday Wednesday NNP work_wgf2msbacfaetpobn6pl73o5ui 64 10 , , , work_wgf2msbacfaetpobn6pl73o5ui 64 11 February February NNP work_wgf2msbacfaetpobn6pl73o5ui 64 12 11 11 CD work_wgf2msbacfaetpobn6pl73o5ui 64 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 64 14 2015 2015 CD work_wgf2msbacfaetpobn6pl73o5ui 64 15 co co NN work_wgf2msbacfaetpobn6pl73o5ui 64 16 - - NN work_wgf2msbacfaetpobn6pl73o5ui 64 17 expression expression NN work_wgf2msbacfaetpobn6pl73o5ui 64 18 and and CC work_wgf2msbacfaetpobn6pl73o5ui 64 19 co co NN work_wgf2msbacfaetpobn6pl73o5ui 64 20 - - NN work_wgf2msbacfaetpobn6pl73o5ui 64 21 evolution evolution NN work_wgf2msbacfaetpobn6pl73o5ui 64 22 with with IN work_wgf2msbacfaetpobn6pl73o5ui 64 23 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 64 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 65 1 MICU1 MICU1 NNP work_wgf2msbacfaetpobn6pl73o5ui 65 2 has have VBZ work_wgf2msbacfaetpobn6pl73o5ui 65 3 been be VBN work_wgf2msbacfaetpobn6pl73o5ui 65 4 demonstrated demonstrate VBN work_wgf2msbacfaetpobn6pl73o5ui 65 5 to to TO work_wgf2msbacfaetpobn6pl73o5ui 65 6 be be VB work_wgf2msbacfaetpobn6pl73o5ui 65 7 a a DT work_wgf2msbacfaetpobn6pl73o5ui 65 8 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 65 9 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 65 10 -sensing -sense VBG work_wgf2msbacfaetpobn6pl73o5ui 65 11 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 65 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 65 13 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 65 14 both both DT work_wgf2msbacfaetpobn6pl73o5ui 65 15 sets set VBZ work_wgf2msbacfaetpobn6pl73o5ui 65 16 a a DT work_wgf2msbacfaetpobn6pl73o5ui 65 17 threshold threshold NN work_wgf2msbacfaetpobn6pl73o5ui 65 18 for for IN work_wgf2msbacfaetpobn6pl73o5ui 65 19 low low JJ work_wgf2msbacfaetpobn6pl73o5ui 65 20 Ca ca NN work_wgf2msbacfaetpobn6pl73o5ui 65 21 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 65 22 concentration concentration NN work_wgf2msbacfaetpobn6pl73o5ui 65 23 while while IN work_wgf2msbacfaetpobn6pl73o5ui 65 24 it -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 65 25 assures assure VBZ work_wgf2msbacfaetpobn6pl73o5ui 65 26 cooperative cooperative JJ work_wgf2msbacfaetpobn6pl73o5ui 65 27 activation activation NN work_wgf2msbacfaetpobn6pl73o5ui 65 28 during during IN work_wgf2msbacfaetpobn6pl73o5ui 65 29 high high JJ work_wgf2msbacfaetpobn6pl73o5ui 65 30 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 65 31 rises rise NNS work_wgf2msbacfaetpobn6pl73o5ui 65 32 . . . work_wgf2msbacfaetpobn6pl73o5ui 66 1 Mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 66 2 Ca2þ Ca2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 66 3 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 66 4 shows show VBZ work_wgf2msbacfaetpobn6pl73o5ui 66 5 tissue tissue NN work_wgf2msbacfaetpobn6pl73o5ui 66 6 specific specific JJ work_wgf2msbacfaetpobn6pl73o5ui 66 7 differences difference NNS work_wgf2msbacfaetpobn6pl73o5ui 66 8 and and CC work_wgf2msbacfaetpobn6pl73o5ui 66 9 interestingly interestingly RB work_wgf2msbacfaetpobn6pl73o5ui 66 10 , , , work_wgf2msbacfaetpobn6pl73o5ui 66 11 mRNA mrna JJ work_wgf2msbacfaetpobn6pl73o5ui 66 12 level level NN work_wgf2msbacfaetpobn6pl73o5ui 66 13 for for IN work_wgf2msbacfaetpobn6pl73o5ui 66 14 MICUs micu NNS work_wgf2msbacfaetpobn6pl73o5ui 66 15 and and CC work_wgf2msbacfaetpobn6pl73o5ui 66 16 MCUs MCUs NNP work_wgf2msbacfaetpobn6pl73o5ui 66 17 also also RB work_wgf2msbacfaetpobn6pl73o5ui 66 18 displays display VBZ work_wgf2msbacfaetpobn6pl73o5ui 66 19 tissue tissue NN work_wgf2msbacfaetpobn6pl73o5ui 66 20 specificity specificity NN work_wgf2msbacfaetpobn6pl73o5ui 66 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 67 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 67 2 set set VBD work_wgf2msbacfaetpobn6pl73o5ui 67 3 out out RP work_wgf2msbacfaetpobn6pl73o5ui 67 4 to to TO work_wgf2msbacfaetpobn6pl73o5ui 67 5 investigate investigate VB work_wgf2msbacfaetpobn6pl73o5ui 67 6 if if IN work_wgf2msbacfaetpobn6pl73o5ui 67 7 the the DT work_wgf2msbacfaetpobn6pl73o5ui 67 8 stoichiometry stoichiometry NN work_wgf2msbacfaetpobn6pl73o5ui 67 9 between between IN work_wgf2msbacfaetpobn6pl73o5ui 67 10 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 67 11 and and CC work_wgf2msbacfaetpobn6pl73o5ui 67 12 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 67 13 could could MD work_wgf2msbacfaetpobn6pl73o5ui 67 14 account account VB work_wgf2msbacfaetpobn6pl73o5ui 67 15 for for IN work_wgf2msbacfaetpobn6pl73o5ui 67 16 the the DT work_wgf2msbacfaetpobn6pl73o5ui 67 17 previously previously RB work_wgf2msbacfaetpobn6pl73o5ui 67 18 described describe VBN work_wgf2msbacfaetpobn6pl73o5ui 67 19 differences difference NNS work_wgf2msbacfaetpobn6pl73o5ui 67 20 between between IN work_wgf2msbacfaetpobn6pl73o5ui 67 21 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 67 22 and and CC work_wgf2msbacfaetpobn6pl73o5ui 67 23 liver liver NN work_wgf2msbacfaetpobn6pl73o5ui 67 24 in in IN work_wgf2msbacfaetpobn6pl73o5ui 67 25 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 67 26 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 67 27 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 67 28 uptake uptake VB work_wgf2msbacfaetpobn6pl73o5ui 67 29 . . . work_wgf2msbacfaetpobn6pl73o5ui 68 1 Immunoblotting immunoblotte VBG work_wgf2msbacfaetpobn6pl73o5ui 68 2 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 68 3 higher high JJR work_wgf2msbacfaetpobn6pl73o5ui 68 4 expression expression NN work_wgf2msbacfaetpobn6pl73o5ui 68 5 for for IN work_wgf2msbacfaetpobn6pl73o5ui 68 6 all all DT work_wgf2msbacfaetpobn6pl73o5ui 68 7 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 68 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 68 9 MICU2 micu2 NN work_wgf2msbacfaetpobn6pl73o5ui 68 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 68 11 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 68 12 in in IN work_wgf2msbacfaetpobn6pl73o5ui 68 13 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 68 14 liver liver NN work_wgf2msbacfaetpobn6pl73o5ui 68 15 versus versus IN work_wgf2msbacfaetpobn6pl73o5ui 68 16 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 68 17 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 68 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 68 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 68 20 a a DT work_wgf2msbacfaetpobn6pl73o5ui 68 21 4.5 4.5 CD work_wgf2msbacfaetpobn6pl73o5ui 68 22 fold fold VB work_wgf2msbacfaetpobn6pl73o5ui 68 23 higher high JJR work_wgf2msbacfaetpobn6pl73o5ui 68 24 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 68 25 to to IN work_wgf2msbacfaetpobn6pl73o5ui 68 26 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 68 27 ratio ratio NN work_wgf2msbacfaetpobn6pl73o5ui 68 28 in in IN work_wgf2msbacfaetpobn6pl73o5ui 68 29 liver liver NN work_wgf2msbacfaetpobn6pl73o5ui 68 30 . . . work_wgf2msbacfaetpobn6pl73o5ui 69 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 69 2 fluorometric fluorometric JJ work_wgf2msbacfaetpobn6pl73o5ui 69 3 measurements measurement NNS work_wgf2msbacfaetpobn6pl73o5ui 69 4 of of IN work_wgf2msbacfaetpobn6pl73o5ui 69 5 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 69 6 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 69 7 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 69 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 69 9 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 69 10 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 69 11 displayed display VBD work_wgf2msbacfaetpobn6pl73o5ui 69 12 a a DT work_wgf2msbacfaetpobn6pl73o5ui 69 13 decreased decreased JJ work_wgf2msbacfaetpobn6pl73o5ui 69 14 threshold threshold NN work_wgf2msbacfaetpobn6pl73o5ui 69 15 and and CC work_wgf2msbacfaetpobn6pl73o5ui 69 16 lesser less JJR work_wgf2msbacfaetpobn6pl73o5ui 69 17 cooperativity cooperativity NN work_wgf2msbacfaetpobn6pl73o5ui 69 18 compared compare VBN work_wgf2msbacfaetpobn6pl73o5ui 69 19 to to IN work_wgf2msbacfaetpobn6pl73o5ui 69 20 liver liver NN work_wgf2msbacfaetpobn6pl73o5ui 69 21 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 69 22 . . . work_wgf2msbacfaetpobn6pl73o5ui 70 1 Additionally additionally RB work_wgf2msbacfaetpobn6pl73o5ui 70 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 70 3 NAD(P)H nad(p)h JJ work_wgf2msbacfaetpobn6pl73o5ui 70 4 elevation elevation NN work_wgf2msbacfaetpobn6pl73o5ui 70 5 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 70 6 detect- detect- JJ work_wgf2msbacfaetpobn6pl73o5ui 70 7 able able JJ work_wgf2msbacfaetpobn6pl73o5ui 70 8 after after IN work_wgf2msbacfaetpobn6pl73o5ui 70 9 exposure exposure NN work_wgf2msbacfaetpobn6pl73o5ui 70 10 to to TO work_wgf2msbacfaetpobn6pl73o5ui 70 11 moderate moderate VB work_wgf2msbacfaetpobn6pl73o5ui 70 12 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 70 13 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 70 14 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 70 15 ] ] -RRB- work_wgf2msbacfaetpobn6pl73o5ui 70 16 elevations elevation NNS work_wgf2msbacfaetpobn6pl73o5ui 70 17 only only RB work_wgf2msbacfaetpobn6pl73o5ui 70 18 in in IN work_wgf2msbacfaetpobn6pl73o5ui 70 19 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 70 20 mitochondria mitochondrion NNS work_wgf2msbacfaetpobn6pl73o5ui 70 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 71 1 Overexpression overexpression NN work_wgf2msbacfaetpobn6pl73o5ui 71 2 of of IN work_wgf2msbacfaetpobn6pl73o5ui 71 3 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 71 4 in in IN work_wgf2msbacfaetpobn6pl73o5ui 71 5 the the DT work_wgf2msbacfaetpobn6pl73o5ui 71 6 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 71 7 using use VBG work_wgf2msbacfaetpobn6pl73o5ui 71 8 AAV9-MICU1 aav9-micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 71 9 tail tail NN work_wgf2msbacfaetpobn6pl73o5ui 71 10 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 71 11 vein vein NN work_wgf2msbacfaetpobn6pl73o5ui 71 12 injection injection NN work_wgf2msbacfaetpobn6pl73o5ui 71 13 significantly significantly RB work_wgf2msbacfaetpobn6pl73o5ui 71 14 increased increase VBD work_wgf2msbacfaetpobn6pl73o5ui 71 15 the the DT work_wgf2msbacfaetpobn6pl73o5ui 71 16 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 71 17 protein protein NN work_wgf2msbacfaetpobn6pl73o5ui 71 18 level level NN work_wgf2msbacfaetpobn6pl73o5ui 71 19 without without IN work_wgf2msbacfaetpobn6pl73o5ui 71 20 any any DT work_wgf2msbacfaetpobn6pl73o5ui 71 21 changes change NNS work_wgf2msbacfaetpobn6pl73o5ui 71 22 of of IN work_wgf2msbacfaetpobn6pl73o5ui 71 23 MICU2 micu2 NN work_wgf2msbacfaetpobn6pl73o5ui 71 24 or or CC work_wgf2msbacfaetpobn6pl73o5ui 71 25 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 71 26 . . . work_wgf2msbacfaetpobn6pl73o5ui 72 1 This this DT work_wgf2msbacfaetpobn6pl73o5ui 72 2 increased increase VBD work_wgf2msbacfaetpobn6pl73o5ui 72 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 72 4 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 72 5 to to IN work_wgf2msbacfaetpobn6pl73o5ui 72 6 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 72 7 ratio ratio NN work_wgf2msbacfaetpobn6pl73o5ui 72 8 in in IN work_wgf2msbacfaetpobn6pl73o5ui 72 9 the the DT work_wgf2msbacfaetpobn6pl73o5ui 72 10 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 72 11 and and CC work_wgf2msbacfaetpobn6pl73o5ui 72 12 led lead VBD work_wgf2msbacfaetpobn6pl73o5ui 72 13 to to IN work_wgf2msbacfaetpobn6pl73o5ui 72 14 increased increase VBN work_wgf2msbacfaetpobn6pl73o5ui 72 15 thresholding thresholding NN work_wgf2msbacfaetpobn6pl73o5ui 72 16 and and CC work_wgf2msbacfaetpobn6pl73o5ui 72 17 cooperativity cooperativity NN work_wgf2msbacfaetpobn6pl73o5ui 72 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 72 19 reproducing reproduce VBG work_wgf2msbacfaetpobn6pl73o5ui 72 20 the the DT work_wgf2msbacfaetpobn6pl73o5ui 72 21 liver liver NN work_wgf2msbacfaetpobn6pl73o5ui 72 22 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 72 23 like like JJ work_wgf2msbacfaetpobn6pl73o5ui 72 24 mito- mito- NN work_wgf2msbacfaetpobn6pl73o5ui 72 25 chondrialCa2þ chondrialCa2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 72 26 uptakephenotype uptakephenotype NN work_wgf2msbacfaetpobn6pl73o5ui 72 27 . . . work_wgf2msbacfaetpobn6pl73o5ui 72 28 ViceversaMICU1downregulationintheliver ViceversaMICU1downregulationintheliver NNP work_wgf2msbacfaetpobn6pl73o5ui 72 29 has have VBZ work_wgf2msbacfaetpobn6pl73o5ui 72 30 been be VBN work_wgf2msbacfaetpobn6pl73o5ui 72 31 shown show VBN work_wgf2msbacfaetpobn6pl73o5ui 72 32 to to IN work_wgf2msbacfaetpobn6pl73o5ui 72 33 lower lower VB work_wgf2msbacfaetpobn6pl73o5ui 72 34 the the DT work_wgf2msbacfaetpobn6pl73o5ui 72 35 threshold threshold NN work_wgf2msbacfaetpobn6pl73o5ui 72 36 and and CC work_wgf2msbacfaetpobn6pl73o5ui 72 37 cooperativity cooperativity NN work_wgf2msbacfaetpobn6pl73o5ui 72 38 of of IN work_wgf2msbacfaetpobn6pl73o5ui 72 39 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 72 40 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 72 41 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 72 42 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 72 43 in in IN work_wgf2msbacfaetpobn6pl73o5ui 72 44 hepatocytes hepatocyte NNS work_wgf2msbacfaetpobn6pl73o5ui 72 45 . . . work_wgf2msbacfaetpobn6pl73o5ui 73 1 Thus thus RB work_wgf2msbacfaetpobn6pl73o5ui 73 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 73 3 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 73 4 and and CC work_wgf2msbacfaetpobn6pl73o5ui 73 5 liver liver NN work_wgf2msbacfaetpobn6pl73o5ui 73 6 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 73 7 show show VBP work_wgf2msbacfaetpobn6pl73o5ui 73 8 different different JJ work_wgf2msbacfaetpobn6pl73o5ui 73 9 levels level NNS work_wgf2msbacfaetpobn6pl73o5ui 73 10 of of IN work_wgf2msbacfaetpobn6pl73o5ui 73 11 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 73 12 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 73 13 threshold threshold JJ work_wgf2msbacfaetpobn6pl73o5ui 73 14 and and CC work_wgf2msbacfaetpobn6pl73o5ui 73 15 cooperative cooperative JJ work_wgf2msbacfaetpobn6pl73o5ui 73 16 activation activation NN work_wgf2msbacfaetpobn6pl73o5ui 73 17 of of IN work_wgf2msbacfaetpobn6pl73o5ui 73 18 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 73 19 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 73 20 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 73 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 73 22 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 73 23 seem seem VBP work_wgf2msbacfaetpobn6pl73o5ui 73 24 to to TO work_wgf2msbacfaetpobn6pl73o5ui 73 25 result result VB work_wgf2msbacfaetpobn6pl73o5ui 73 26 from from IN work_wgf2msbacfaetpobn6pl73o5ui 73 27 differential differential NN work_wgf2msbacfaetpobn6pl73o5ui 73 28 quantitative quantitative JJ work_wgf2msbacfaetpobn6pl73o5ui 73 29 relationship relationship NN work_wgf2msbacfaetpobn6pl73o5ui 73 30 between between IN work_wgf2msbacfaetpobn6pl73o5ui 73 31 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 73 32 and and CC work_wgf2msbacfaetpobn6pl73o5ui 73 33 MCU mcu NN work_wgf2msbacfaetpobn6pl73o5ui 73 34 . . . work_wgf2msbacfaetpobn6pl73o5ui 74 1 3076-Pos 3076-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 74 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 74 3 B506 B506 NNP work_wgf2msbacfaetpobn6pl73o5ui 74 4 ER ER NNP work_wgf2msbacfaetpobn6pl73o5ui 74 5 Calcium Calcium NNP work_wgf2msbacfaetpobn6pl73o5ui 74 6 Release Release NNP work_wgf2msbacfaetpobn6pl73o5ui 74 7 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 74 8 Tuned tune VBN work_wgf2msbacfaetpobn6pl73o5ui 74 9 by by IN work_wgf2msbacfaetpobn6pl73o5ui 74 10 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 74 11 Redox Redox NNP work_wgf2msbacfaetpobn6pl73o5ui 74 12 Nanodomains Nanodomains NNP work_wgf2msbacfaetpobn6pl73o5ui 74 13 David David NNP work_wgf2msbacfaetpobn6pl73o5ui 74 14 M. M. NNP work_wgf2msbacfaetpobn6pl73o5ui 74 15 Booth1 Booth1 NNP work_wgf2msbacfaetpobn6pl73o5ui 74 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 74 17 Balázs Balázs NNP work_wgf2msbacfaetpobn6pl73o5ui 74 18 Enyedi2 Enyedi2 NNP work_wgf2msbacfaetpobn6pl73o5ui 74 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 74 20 Miklós Miklós NNP work_wgf2msbacfaetpobn6pl73o5ui 74 21 Geiszt2 Geiszt2 NNP work_wgf2msbacfaetpobn6pl73o5ui 74 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 74 23 Péter péter CD work_wgf2msbacfaetpobn6pl73o5ui 74 24 Várnai2 várnai2 CD work_wgf2msbacfaetpobn6pl73o5ui 74 25 , , , work_wgf2msbacfaetpobn6pl73o5ui 74 26 György György NNP work_wgf2msbacfaetpobn6pl73o5ui 74 27 Hajnóczky1 Hajnóczky1 NNP work_wgf2msbacfaetpobn6pl73o5ui 74 28 . . . work_wgf2msbacfaetpobn6pl73o5ui 75 1 1MitoCare 1mitocare CD work_wgf2msbacfaetpobn6pl73o5ui 75 2 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 75 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 4 Pathology Pathology NNP work_wgf2msbacfaetpobn6pl73o5ui 75 5 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 6 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 75 7 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 75 8 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 75 9 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 10 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 75 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 12 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 75 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 14 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 75 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 16 2Department 2department CD work_wgf2msbacfaetpobn6pl73o5ui 75 17 of of IN work_wgf2msbacfaetpobn6pl73o5ui 75 18 Physiology Physiology NNP work_wgf2msbacfaetpobn6pl73o5ui 75 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 20 Semmelweis Semmelweis NNP work_wgf2msbacfaetpobn6pl73o5ui 75 21 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 75 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 23 Budapest Budapest NNP work_wgf2msbacfaetpobn6pl73o5ui 75 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 75 25 Hungary Hungary NNP work_wgf2msbacfaetpobn6pl73o5ui 75 26 . . . work_wgf2msbacfaetpobn6pl73o5ui 76 1 Spatially spatially RB work_wgf2msbacfaetpobn6pl73o5ui 76 2 and and CC work_wgf2msbacfaetpobn6pl73o5ui 76 3 temporally temporally RB work_wgf2msbacfaetpobn6pl73o5ui 76 4 controlled control VBN work_wgf2msbacfaetpobn6pl73o5ui 76 5 increases increase NNS work_wgf2msbacfaetpobn6pl73o5ui 76 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 76 7 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 76 8 emerge emerge NN work_wgf2msbacfaetpobn6pl73o5ui 76 9 as as IN work_wgf2msbacfaetpobn6pl73o5ui 76 10 an an DT work_wgf2msbacfaetpobn6pl73o5ui 76 11 intracellular intracellular JJ work_wgf2msbacfaetpobn6pl73o5ui 76 12 signal signal NN work_wgf2msbacfaetpobn6pl73o5ui 76 13 . . . work_wgf2msbacfaetpobn6pl73o5ui 77 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 77 2 hypothesized hypothesize VBD work_wgf2msbacfaetpobn6pl73o5ui 77 3 that that DT work_wgf2msbacfaetpobn6pl73o5ui 77 4 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 77 5 and and CC work_wgf2msbacfaetpobn6pl73o5ui 77 6 Ca Ca MD work_wgf2msbacfaetpobn6pl73o5ui 77 7 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 77 8 interact interact VB work_wgf2msbacfaetpobn6pl73o5ui 77 9 locally locally RB work_wgf2msbacfaetpobn6pl73o5ui 77 10 , , , work_wgf2msbacfaetpobn6pl73o5ui 77 11 in in IN work_wgf2msbacfaetpobn6pl73o5ui 77 12 the the DT work_wgf2msbacfaetpobn6pl73o5ui 77 13 restricted restricted JJ work_wgf2msbacfaetpobn6pl73o5ui 77 14 vol- vol- NN work_wgf2msbacfaetpobn6pl73o5ui 77 15 ume ume NN work_wgf2msbacfaetpobn6pl73o5ui 77 16 of of IN work_wgf2msbacfaetpobn6pl73o5ui 77 17 the the DT work_wgf2msbacfaetpobn6pl73o5ui 77 18 ER ER NNP work_wgf2msbacfaetpobn6pl73o5ui 77 19 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 77 20 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 77 21 interface interface NN work_wgf2msbacfaetpobn6pl73o5ui 77 22 . . . work_wgf2msbacfaetpobn6pl73o5ui 78 1 These these DT work_wgf2msbacfaetpobn6pl73o5ui 78 2 physically physically RB work_wgf2msbacfaetpobn6pl73o5ui 78 3 tethered tether VBN work_wgf2msbacfaetpobn6pl73o5ui 78 4 structures structure NNS work_wgf2msbacfaetpobn6pl73o5ui 78 5 host host VBP work_wgf2msbacfaetpobn6pl73o5ui 78 6 enrichments enrichment NNS work_wgf2msbacfaetpobn6pl73o5ui 78 7 of of IN work_wgf2msbacfaetpobn6pl73o5ui 78 8 ion ion NN work_wgf2msbacfaetpobn6pl73o5ui 78 9 transport transport NN work_wgf2msbacfaetpobn6pl73o5ui 78 10 proteins protein NNS work_wgf2msbacfaetpobn6pl73o5ui 78 11 such such JJ work_wgf2msbacfaetpobn6pl73o5ui 78 12 as as IN work_wgf2msbacfaetpobn6pl73o5ui 78 13 the the DT work_wgf2msbacfaetpobn6pl73o5ui 78 14 IP3 IP3 NNP work_wgf2msbacfaetpobn6pl73o5ui 78 15 receptor receptor NN work_wgf2msbacfaetpobn6pl73o5ui 78 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 78 17 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 78 18 support support VBP work_wgf2msbacfaetpobn6pl73o5ui 78 19 elevated elevated JJ work_wgf2msbacfaetpobn6pl73o5ui 78 20 nanodomains nanodomain NNS work_wgf2msbacfaetpobn6pl73o5ui 78 21 of of IN work_wgf2msbacfaetpobn6pl73o5ui 78 22 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 78 23 during during IN work_wgf2msbacfaetpobn6pl73o5ui 78 24 signalling signal VBG work_wgf2msbacfaetpobn6pl73o5ui 78 25 events event NNS work_wgf2msbacfaetpobn6pl73o5ui 78 26 and and CC work_wgf2msbacfaetpobn6pl73o5ui 78 27 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 78 28 sensitive sensitive JJ work_wgf2msbacfaetpobn6pl73o5ui 78 29 to to IN work_wgf2msbacfaetpobn6pl73o5ui 78 30 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 78 31 . . . work_wgf2msbacfaetpobn6pl73o5ui 79 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 79 2 used use VBD work_wgf2msbacfaetpobn6pl73o5ui 79 3 the the DT work_wgf2msbacfaetpobn6pl73o5ui 79 4 genetically genetically RB work_wgf2msbacfaetpobn6pl73o5ui 79 5 encoded encode VBN work_wgf2msbacfaetpobn6pl73o5ui 79 6 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 79 7 sensor sensor NN work_wgf2msbacfaetpobn6pl73o5ui 79 8 HyPer HyPer NNP work_wgf2msbacfaetpobn6pl73o5ui 79 9 incorporated incorporate VBD work_wgf2msbacfaetpobn6pl73o5ui 79 10 into into IN work_wgf2msbacfaetpobn6pl73o5ui 79 11 an an DT work_wgf2msbacfaetpobn6pl73o5ui 79 12 inducible inducible JJ work_wgf2msbacfaetpobn6pl73o5ui 79 13 linker linker NN work_wgf2msbacfaetpobn6pl73o5ui 79 14 system system NN work_wgf2msbacfaetpobn6pl73o5ui 79 15 to to TO work_wgf2msbacfaetpobn6pl73o5ui 79 16 probe probe VB work_wgf2msbacfaetpobn6pl73o5ui 79 17 the the DT work_wgf2msbacfaetpobn6pl73o5ui 79 18 redox redox JJ work_wgf2msbacfaetpobn6pl73o5ui 79 19 environment environment NN work_wgf2msbacfaetpobn6pl73o5ui 79 20 at at IN work_wgf2msbacfaetpobn6pl73o5ui 79 21 the the DT work_wgf2msbacfaetpobn6pl73o5ui 79 22 ER- ER- NNP work_wgf2msbacfaetpobn6pl73o5ui 79 23 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 79 24 interface interface NN work_wgf2msbacfaetpobn6pl73o5ui 79 25 in in IN work_wgf2msbacfaetpobn6pl73o5ui 79 26 HepG2 HepG2 NNP work_wgf2msbacfaetpobn6pl73o5ui 79 27 cells cell NNS work_wgf2msbacfaetpobn6pl73o5ui 79 28 . . . work_wgf2msbacfaetpobn6pl73o5ui 80 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 80 2 found find VBD work_wgf2msbacfaetpobn6pl73o5ui 80 3 a a DT work_wgf2msbacfaetpobn6pl73o5ui 80 4 moderately moderately RB work_wgf2msbacfaetpobn6pl73o5ui 80 5 elevated elevated JJ work_wgf2msbacfaetpobn6pl73o5ui 80 6 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 80 7 nanodomain nanodomain NN work_wgf2msbacfaetpobn6pl73o5ui 80 8 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 80 9 developes develop VBZ work_wgf2msbacfaetpobn6pl73o5ui 80 10 into into IN work_wgf2msbacfaetpobn6pl73o5ui 80 11 a a DT work_wgf2msbacfaetpobn6pl73o5ui 80 12 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 80 13 transient transient NN work_wgf2msbacfaetpobn6pl73o5ui 80 14 following follow VBG work_wgf2msbacfaetpobn6pl73o5ui 80 15 IP3 IP3 NNP work_wgf2msbacfaetpobn6pl73o5ui 80 16 receptor- receptor- NN work_wgf2msbacfaetpobn6pl73o5ui 80 17 mediated mediate VBN work_wgf2msbacfaetpobn6pl73o5ui 80 18 ER ER NNP work_wgf2msbacfaetpobn6pl73o5ui 80 19 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 80 20 release release NN work_wgf2msbacfaetpobn6pl73o5ui 80 21 and and CC work_wgf2msbacfaetpobn6pl73o5ui 80 22 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 80 23 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 80 24 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 80 25 . . . work_wgf2msbacfaetpobn6pl73o5ui 81 1 Pharmacological pharmacological JJ work_wgf2msbacfaetpobn6pl73o5ui 81 2 in- in- JJ work_wgf2msbacfaetpobn6pl73o5ui 81 3 hibition hibition NN work_wgf2msbacfaetpobn6pl73o5ui 81 4 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 81 5 that that IN work_wgf2msbacfaetpobn6pl73o5ui 81 6 the the DT work_wgf2msbacfaetpobn6pl73o5ui 81 7 transient transient NN work_wgf2msbacfaetpobn6pl73o5ui 81 8 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 81 9 dependent dependent JJ work_wgf2msbacfaetpobn6pl73o5ui 81 10 upon upon IN work_wgf2msbacfaetpobn6pl73o5ui 81 11 ER ER NNP work_wgf2msbacfaetpobn6pl73o5ui 81 12 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 81 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 81 14 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 81 15 membrane membrane NN work_wgf2msbacfaetpobn6pl73o5ui 81 16 potential potential NN work_wgf2msbacfaetpobn6pl73o5ui 81 17 and and CC work_wgf2msbacfaetpobn6pl73o5ui 81 18 functional functional JJ work_wgf2msbacfaetpobn6pl73o5ui 81 19 electron electron NN work_wgf2msbacfaetpobn6pl73o5ui 81 20 transport transport NN work_wgf2msbacfaetpobn6pl73o5ui 81 21 chain chain NN work_wgf2msbacfaetpobn6pl73o5ui 81 22 . . . work_wgf2msbacfaetpobn6pl73o5ui 82 1 HyPer HyPer NNP work_wgf2msbacfaetpobn6pl73o5ui 82 2 measure- measure- JJ work_wgf2msbacfaetpobn6pl73o5ui 82 3 ments ment NNS work_wgf2msbacfaetpobn6pl73o5ui 82 4 of of IN work_wgf2msbacfaetpobn6pl73o5ui 82 5 the the DT work_wgf2msbacfaetpobn6pl73o5ui 82 6 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 82 7 intermembrane intermembrane NN work_wgf2msbacfaetpobn6pl73o5ui 82 8 space space NN work_wgf2msbacfaetpobn6pl73o5ui 82 9 revealed reveal VBD work_wgf2msbacfaetpobn6pl73o5ui 82 10 significantly significantly RB work_wgf2msbacfaetpobn6pl73o5ui 82 11 elevated elevate VBD work_wgf2msbacfaetpobn6pl73o5ui 82 12 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 82 13 within within IN work_wgf2msbacfaetpobn6pl73o5ui 82 14 this this DT work_wgf2msbacfaetpobn6pl73o5ui 82 15 volume volume NN work_wgf2msbacfaetpobn6pl73o5ui 82 16 . . . work_wgf2msbacfaetpobn6pl73o5ui 83 1 Using use VBG work_wgf2msbacfaetpobn6pl73o5ui 83 2 electron electron NN work_wgf2msbacfaetpobn6pl73o5ui 83 3 microscopy microscopy JJ work_wgf2msbacfaetpobn6pl73o5ui 83 4 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 83 5 found find VBD work_wgf2msbacfaetpobn6pl73o5ui 83 6 that that IN work_wgf2msbacfaetpobn6pl73o5ui 83 7 HepG2 HepG2 NNP work_wgf2msbacfaetpobn6pl73o5ui 83 8 mito- mito- NN work_wgf2msbacfaetpobn6pl73o5ui 83 9 chondria chondria NNP work_wgf2msbacfaetpobn6pl73o5ui 83 10 possess possess VBP work_wgf2msbacfaetpobn6pl73o5ui 83 11 a a DT work_wgf2msbacfaetpobn6pl73o5ui 83 12 cohort cohort NN work_wgf2msbacfaetpobn6pl73o5ui 83 13 of of IN work_wgf2msbacfaetpobn6pl73o5ui 83 14 dilated dilated JJ work_wgf2msbacfaetpobn6pl73o5ui 83 15 cristae cristae NN work_wgf2msbacfaetpobn6pl73o5ui 83 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 83 17 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 83 18 disappeared disappear VBD work_wgf2msbacfaetpobn6pl73o5ui 83 19 following follow VBG work_wgf2msbacfaetpobn6pl73o5ui 83 20 IP3- IP3- NNP work_wgf2msbacfaetpobn6pl73o5ui 83 21 linked link VBN work_wgf2msbacfaetpobn6pl73o5ui 83 22 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 83 23 release release NN work_wgf2msbacfaetpobn6pl73o5ui 83 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 84 1 Paxilline Paxilline NNP work_wgf2msbacfaetpobn6pl73o5ui 84 2 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 84 3 inhibits inhibit VBZ work_wgf2msbacfaetpobn6pl73o5ui 84 4 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 84 5 BKCa BKCa NNS work_wgf2msbacfaetpobn6pl73o5ui 84 6 channels channel NNS work_wgf2msbacfaetpobn6pl73o5ui 84 7 blocked block VBD work_wgf2msbacfaetpobn6pl73o5ui 84 8 the the DT work_wgf2msbacfaetpobn6pl73o5ui 84 9 cristae cristae NN work_wgf2msbacfaetpobn6pl73o5ui 84 10 reshaping reshape VBG work_wgf2msbacfaetpobn6pl73o5ui 84 11 and and CC work_wgf2msbacfaetpobn6pl73o5ui 84 12 also also RB work_wgf2msbacfaetpobn6pl73o5ui 84 13 abolished abolish VBD work_wgf2msbacfaetpobn6pl73o5ui 84 14 the the DT work_wgf2msbacfaetpobn6pl73o5ui 84 15 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 84 16 transient transient NN work_wgf2msbacfaetpobn6pl73o5ui 84 17 at at IN work_wgf2msbacfaetpobn6pl73o5ui 84 18 the the DT work_wgf2msbacfaetpobn6pl73o5ui 84 19 inter- inter- NN work_wgf2msbacfaetpobn6pl73o5ui 84 20 face face NN work_wgf2msbacfaetpobn6pl73o5ui 84 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 85 1 Furthermore furthermore RB work_wgf2msbacfaetpobn6pl73o5ui 85 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 85 3 paxilline paxilline NN work_wgf2msbacfaetpobn6pl73o5ui 85 4 caused cause VBD work_wgf2msbacfaetpobn6pl73o5ui 85 5 suppression suppression NN work_wgf2msbacfaetpobn6pl73o5ui 85 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 85 7 the the DT work_wgf2msbacfaetpobn6pl73o5ui 85 8 IP3-linked ip3-linked JJ work_wgf2msbacfaetpobn6pl73o5ui 85 9 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 85 10 signal signal NN work_wgf2msbacfaetpobn6pl73o5ui 85 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 85 12 whereas whereas IN work_wgf2msbacfaetpobn6pl73o5ui 85 13 interface interface NN work_wgf2msbacfaetpobn6pl73o5ui 85 14 targeted target VBD work_wgf2msbacfaetpobn6pl73o5ui 85 15 killer killer NN work_wgf2msbacfaetpobn6pl73o5ui 85 16 red red NN work_wgf2msbacfaetpobn6pl73o5ui 85 17 , , , work_wgf2msbacfaetpobn6pl73o5ui 85 18 a a DT work_wgf2msbacfaetpobn6pl73o5ui 85 19 photoactivated photoactivate VBN work_wgf2msbacfaetpobn6pl73o5ui 85 20 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 85 21 source source NN work_wgf2msbacfaetpobn6pl73o5ui 85 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 85 23 induced induce VBN work_wgf2msbacfaetpobn6pl73o5ui 85 24 sensitization sensitization NN work_wgf2msbacfaetpobn6pl73o5ui 85 25 to to IN work_wgf2msbacfaetpobn6pl73o5ui 85 26 the the DT work_wgf2msbacfaetpobn6pl73o5ui 85 27 IP3-linked ip3-linked JJ work_wgf2msbacfaetpobn6pl73o5ui 85 28 agonist agonist NN work_wgf2msbacfaetpobn6pl73o5ui 85 29 . . . work_wgf2msbacfaetpobn6pl73o5ui 86 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 86 2 conclude conclude VBP work_wgf2msbacfaetpobn6pl73o5ui 86 3 that that IN work_wgf2msbacfaetpobn6pl73o5ui 86 4 the the DT work_wgf2msbacfaetpobn6pl73o5ui 86 5 intermembrane/ intermembrane/ NNP work_wgf2msbacfaetpobn6pl73o5ui 86 6 cristae cristae NN work_wgf2msbacfaetpobn6pl73o5ui 86 7 volume volume NN work_wgf2msbacfaetpobn6pl73o5ui 86 8 of of IN work_wgf2msbacfaetpobn6pl73o5ui 86 9 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 86 10 represents represent VBZ work_wgf2msbacfaetpobn6pl73o5ui 86 11 an an DT work_wgf2msbacfaetpobn6pl73o5ui 86 12 oxidized oxidized JJ work_wgf2msbacfaetpobn6pl73o5ui 86 13 pool pool NN work_wgf2msbacfaetpobn6pl73o5ui 86 14 fed feed VBN work_wgf2msbacfaetpobn6pl73o5ui 86 15 by by IN work_wgf2msbacfaetpobn6pl73o5ui 86 16 the the DT work_wgf2msbacfaetpobn6pl73o5ui 86 17 electron electron NNP work_wgf2msbacfaetpobn6pl73o5ui 86 18 transport transport NN work_wgf2msbacfaetpobn6pl73o5ui 86 19 chain chain NN work_wgf2msbacfaetpobn6pl73o5ui 86 20 . . . work_wgf2msbacfaetpobn6pl73o5ui 87 1 Ca ca NN work_wgf2msbacfaetpobn6pl73o5ui 87 2 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 87 3 -uptake -uptake NN work_wgf2msbacfaetpobn6pl73o5ui 87 4 stimulates stimulate VBZ work_wgf2msbacfaetpobn6pl73o5ui 87 5 expansion expansion NN work_wgf2msbacfaetpobn6pl73o5ui 87 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 87 7 the the DT work_wgf2msbacfaetpobn6pl73o5ui 87 8 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 87 9 matrix matrix NN work_wgf2msbacfaetpobn6pl73o5ui 87 10 via via IN work_wgf2msbacfaetpobn6pl73o5ui 87 11 Kþ Kþ NNP work_wgf2msbacfaetpobn6pl73o5ui 87 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 87 13 concomitant concomitant JJ work_wgf2msbacfaetpobn6pl73o5ui 87 14 water water NN work_wgf2msbacfaetpobn6pl73o5ui 87 15 uptake uptake NN work_wgf2msbacfaetpobn6pl73o5ui 87 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 87 17 squeezing squeeze VBG work_wgf2msbacfaetpobn6pl73o5ui 87 18 the the DT work_wgf2msbacfaetpobn6pl73o5ui 87 19 oxidized oxidize VBN work_wgf2msbacfaetpobn6pl73o5ui 87 20 volume volume NN work_wgf2msbacfaetpobn6pl73o5ui 87 21 of of IN work_wgf2msbacfaetpobn6pl73o5ui 87 22 the the DT work_wgf2msbacfaetpobn6pl73o5ui 87 23 cristae cristae NN work_wgf2msbacfaetpobn6pl73o5ui 87 24 to to IN work_wgf2msbacfaetpobn6pl73o5ui 87 25 the the DT work_wgf2msbacfaetpobn6pl73o5ui 87 26 interface interface NN work_wgf2msbacfaetpobn6pl73o5ui 87 27 . . . work_wgf2msbacfaetpobn6pl73o5ui 88 1 Here here RB work_wgf2msbacfaetpobn6pl73o5ui 88 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 88 3 a a DT work_wgf2msbacfaetpobn6pl73o5ui 88 4 transient transient JJ work_wgf2msbacfaetpobn6pl73o5ui 88 5 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 88 6 nanodomain nanodomain NN work_wgf2msbacfaetpobn6pl73o5ui 88 7 sensitizes sensitize VBZ work_wgf2msbacfaetpobn6pl73o5ui 88 8 IP3 IP3 NNP work_wgf2msbacfaetpobn6pl73o5ui 88 9 recep- recep- VBD work_wgf2msbacfaetpobn6pl73o5ui 88 10 tors tor NNS work_wgf2msbacfaetpobn6pl73o5ui 88 11 to to IN work_wgf2msbacfaetpobn6pl73o5ui 88 12 further further JJ work_wgf2msbacfaetpobn6pl73o5ui 88 13 stimulation stimulation NN work_wgf2msbacfaetpobn6pl73o5ui 88 14 . . . work_wgf2msbacfaetpobn6pl73o5ui 89 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 89 2 demonstrate demonstrate VBP work_wgf2msbacfaetpobn6pl73o5ui 89 3 a a DT work_wgf2msbacfaetpobn6pl73o5ui 89 4 physiological physiological JJ work_wgf2msbacfaetpobn6pl73o5ui 89 5 setting setting NN work_wgf2msbacfaetpobn6pl73o5ui 89 6 where where WRB work_wgf2msbacfaetpobn6pl73o5ui 89 7 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 89 8 release release NN work_wgf2msbacfaetpobn6pl73o5ui 89 9 may may MD work_wgf2msbacfaetpobn6pl73o5ui 89 10 autoregulate autoregulate VB work_wgf2msbacfaetpobn6pl73o5ui 89 11 using use VBG work_wgf2msbacfaetpobn6pl73o5ui 89 12 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 89 13 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 89 14 released release VBD work_wgf2msbacfaetpobn6pl73o5ui 89 15 from from IN work_wgf2msbacfaetpobn6pl73o5ui 89 16 the the DT work_wgf2msbacfaetpobn6pl73o5ui 89 17 cristae cristae NN work_wgf2msbacfaetpobn6pl73o5ui 89 18 . . . work_wgf2msbacfaetpobn6pl73o5ui 90 1 3077-Pos 3077-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 90 2 Board Board NNP work_wgf2msbacfaetpobn6pl73o5ui 90 3 B507 B507 NNP work_wgf2msbacfaetpobn6pl73o5ui 90 4 Reactive Reactive NNP work_wgf2msbacfaetpobn6pl73o5ui 90 5 Oxygen Oxygen NNP work_wgf2msbacfaetpobn6pl73o5ui 90 6 Species Species NNPS work_wgf2msbacfaetpobn6pl73o5ui 90 7 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 90 8 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 90 9 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 90 10 Suppress Suppress NNP work_wgf2msbacfaetpobn6pl73o5ui 90 11 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 90 12 Motility Motility NNP work_wgf2msbacfaetpobn6pl73o5ui 90 13 Valentina Valentina NNP work_wgf2msbacfaetpobn6pl73o5ui 90 14 Debattisti Debattisti NNP work_wgf2msbacfaetpobn6pl73o5ui 90 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 90 16 Masao Masao NNP work_wgf2msbacfaetpobn6pl73o5ui 90 17 Saotome Saotome NNP work_wgf2msbacfaetpobn6pl73o5ui 90 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 90 19 Sudipto Sudipto NNP work_wgf2msbacfaetpobn6pl73o5ui 90 20 Das Das NNP work_wgf2msbacfaetpobn6pl73o5ui 90 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 90 22 Gyorgy Gyorgy NNP work_wgf2msbacfaetpobn6pl73o5ui 90 23 Hajnoczky Hajnoczky NNP work_wgf2msbacfaetpobn6pl73o5ui 90 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 91 1 MitoCare MitoCare NNP work_wgf2msbacfaetpobn6pl73o5ui 91 2 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 91 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 91 4 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 91 5 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 91 6 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 91 7 , , , work_wgf2msbacfaetpobn6pl73o5ui 91 8 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 91 9 , , , work_wgf2msbacfaetpobn6pl73o5ui 91 10 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 91 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 91 12 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 91 13 . . . work_wgf2msbacfaetpobn6pl73o5ui 92 1 Mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 92 2 distribution distribution NN work_wgf2msbacfaetpobn6pl73o5ui 92 3 and and CC work_wgf2msbacfaetpobn6pl73o5ui 92 4 transport transport NN work_wgf2msbacfaetpobn6pl73o5ui 92 5 play play VBP work_wgf2msbacfaetpobn6pl73o5ui 92 6 pivotal pivotal JJ work_wgf2msbacfaetpobn6pl73o5ui 92 7 roles role NNS work_wgf2msbacfaetpobn6pl73o5ui 92 8 for for IN work_wgf2msbacfaetpobn6pl73o5ui 92 9 many many JJ work_wgf2msbacfaetpobn6pl73o5ui 92 10 cellular cellular JJ work_wgf2msbacfaetpobn6pl73o5ui 92 11 functions function NNS work_wgf2msbacfaetpobn6pl73o5ui 92 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 92 13 including include VBG work_wgf2msbacfaetpobn6pl73o5ui 92 14 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 92 15 differentiation differentiation NN work_wgf2msbacfaetpobn6pl73o5ui 92 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 92 17 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 92 18 division division NN work_wgf2msbacfaetpobn6pl73o5ui 92 19 to to TO work_wgf2msbacfaetpobn6pl73o5ui 92 20 ensure ensure VB work_wgf2msbacfaetpobn6pl73o5ui 92 21 proper proper JJ work_wgf2msbacfaetpobn6pl73o5ui 92 22 inheri- inheri- NN work_wgf2msbacfaetpobn6pl73o5ui 92 23 tance tance NN work_wgf2msbacfaetpobn6pl73o5ui 92 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 92 25 apoptosis apoptosis NN work_wgf2msbacfaetpobn6pl73o5ui 92 26 , , , work_wgf2msbacfaetpobn6pl73o5ui 92 27 ATP atp NN work_wgf2msbacfaetpobn6pl73o5ui 92 28 supply supply NN work_wgf2msbacfaetpobn6pl73o5ui 92 29 at at IN work_wgf2msbacfaetpobn6pl73o5ui 92 30 the the DT work_wgf2msbacfaetpobn6pl73o5ui 92 31 local local JJ work_wgf2msbacfaetpobn6pl73o5ui 92 32 sites site NNS work_wgf2msbacfaetpobn6pl73o5ui 92 33 of of IN work_wgf2msbacfaetpobn6pl73o5ui 92 34 demand demand NN work_wgf2msbacfaetpobn6pl73o5ui 92 35 , , , work_wgf2msbacfaetpobn6pl73o5ui 92 36 Ca ca NN work_wgf2msbacfaetpobn6pl73o5ui 92 37 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 92 38 buffering buffer VBG work_wgf2msbacfaetpobn6pl73o5ui 92 39 for for IN work_wgf2msbacfaetpobn6pl73o5ui 92 40 intracellular intracellular JJ work_wgf2msbacfaetpobn6pl73o5ui 92 41 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 92 42 homeostasis homeostasis NN work_wgf2msbacfaetpobn6pl73o5ui 92 43 . . . work_wgf2msbacfaetpobn6pl73o5ui 93 1 We -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 93 2 previously previously RB work_wgf2msbacfaetpobn6pl73o5ui 93 3 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 93 4 that that IN work_wgf2msbacfaetpobn6pl73o5ui 93 5 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 93 6 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 93 7 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 93 8 mito mito NNP work_wgf2msbacfaetpobn6pl73o5ui 93 9 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 93 10 motility motility NNP work_wgf2msbacfaetpobn6pl73o5ui 93 11 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 93 12 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 93 13 regulated regulate VBN work_wgf2msbacfaetpobn6pl73o5ui 93 14 by by IN work_wgf2msbacfaetpobn6pl73o5ui 93 15 the the DT work_wgf2msbacfaetpobn6pl73o5ui 93 16 cytosolic cytosolic JJ work_wgf2msbacfaetpobn6pl73o5ui 93 17 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 93 18 concentration concentration NN work_wgf2msbacfaetpobn6pl73o5ui 93 19 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 93 20 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 93 21 Ca2þ]c ca2þ]c NN work_wgf2msbacfaetpobn6pl73o5ui 93 22 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 93 23 , , , work_wgf2msbacfaetpobn6pl73o5ui 93 24 providing provide VBG work_wgf2msbacfaetpobn6pl73o5ui 93 25 the the DT work_wgf2msbacfaetpobn6pl73o5ui 93 26 basis basis NN work_wgf2msbacfaetpobn6pl73o5ui 93 27 for for IN work_wgf2msbacfaetpobn6pl73o5ui 93 28 a a DT work_wgf2msbacfaetpobn6pl73o5ui 93 29 homeostatic homeostatic JJ work_wgf2msbacfaetpobn6pl73o5ui 93 30 circuit circuit NN work_wgf2msbacfaetpobn6pl73o5ui 93 31 in in IN work_wgf2msbacfaetpobn6pl73o5ui 93 32 which which WDT work_wgf2msbacfaetpobn6pl73o5ui 93 33 the the DT work_wgf2msbacfaetpobn6pl73o5ui 93 34 organelles organelle NNS work_wgf2msbacfaetpobn6pl73o5ui 93 35 decrease decrease VBP work_wgf2msbacfaetpobn6pl73o5ui 93 36 their -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 93 37 movements movement NNS work_wgf2msbacfaetpobn6pl73o5ui 93 38 along along IN work_wgf2msbacfaetpobn6pl73o5ui 93 39 microtubules microtubule NNS work_wgf2msbacfaetpobn6pl73o5ui 93 40 to to TO work_wgf2msbacfaetpobn6pl73o5ui 93 41 locally locally RB work_wgf2msbacfaetpobn6pl73o5ui 93 42 buffer buffer VB work_wgf2msbacfaetpobn6pl73o5ui 93 43 high high JJ work_wgf2msbacfaetpobn6pl73o5ui 93 44 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 93 45 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 93 46 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 93 47 ] ] -RRB- work_wgf2msbacfaetpobn6pl73o5ui 93 48 c c NN work_wgf2msbacfaetpobn6pl73o5ui 93 49 and and CC work_wgf2msbacfaetpobn6pl73o5ui 93 50 contribute contribute VB work_wgf2msbacfaetpobn6pl73o5ui 93 51 to to IN work_wgf2msbacfaetpobn6pl73o5ui 93 52 ATP atp NN work_wgf2msbacfaetpobn6pl73o5ui 93 53 supply supply NN work_wgf2msbacfaetpobn6pl73o5ui 93 54 . . . work_wgf2msbacfaetpobn6pl73o5ui 94 1 Mito- Mito- NNP work_wgf2msbacfaetpobn6pl73o5ui 94 2 chondria chondria NNP work_wgf2msbacfaetpobn6pl73o5ui 94 3 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 94 4 also also RB work_wgf2msbacfaetpobn6pl73o5ui 94 5 a a DT work_wgf2msbacfaetpobn6pl73o5ui 94 6 major major JJ work_wgf2msbacfaetpobn6pl73o5ui 94 7 site site NN work_wgf2msbacfaetpobn6pl73o5ui 94 8 for for IN work_wgf2msbacfaetpobn6pl73o5ui 94 9 production production NN work_wgf2msbacfaetpobn6pl73o5ui 94 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 94 11 scavenging scavenging NN work_wgf2msbacfaetpobn6pl73o5ui 94 12 of of IN work_wgf2msbacfaetpobn6pl73o5ui 94 13 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 94 14 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 94 15 serve serve VBP work_wgf2msbacfaetpobn6pl73o5ui 94 16 as as IN work_wgf2msbacfaetpobn6pl73o5ui 94 17 both both CC work_wgf2msbacfaetpobn6pl73o5ui 94 18 a a DT work_wgf2msbacfaetpobn6pl73o5ui 94 19 messenger messenger NN work_wgf2msbacfaetpobn6pl73o5ui 94 20 and and CC work_wgf2msbacfaetpobn6pl73o5ui 94 21 regulator regulator NN work_wgf2msbacfaetpobn6pl73o5ui 94 22 of of IN work_wgf2msbacfaetpobn6pl73o5ui 94 23 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 94 24 signaling signaling NN work_wgf2msbacfaetpobn6pl73o5ui 94 25 and and CC work_wgf2msbacfaetpobn6pl73o5ui 94 26 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 94 27 particularly particularly RB work_wgf2msbacfaetpobn6pl73o5ui 94 28 rele- rele- JJ work_wgf2msbacfaetpobn6pl73o5ui 94 29 vant vant JJ work_wgf2msbacfaetpobn6pl73o5ui 94 30 for for IN work_wgf2msbacfaetpobn6pl73o5ui 94 31 the the DT work_wgf2msbacfaetpobn6pl73o5ui 94 32 control control NN work_wgf2msbacfaetpobn6pl73o5ui 94 33 of of IN work_wgf2msbacfaetpobn6pl73o5ui 94 34 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 94 35 function function NN work_wgf2msbacfaetpobn6pl73o5ui 94 36 . . . work_wgf2msbacfaetpobn6pl73o5ui 95 1 Here here RB work_wgf2msbacfaetpobn6pl73o5ui 95 2 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 95 3 tested test VBD work_wgf2msbacfaetpobn6pl73o5ui 95 4 the the DT work_wgf2msbacfaetpobn6pl73o5ui 95 5 hypothesis hypothesis NN work_wgf2msbacfaetpobn6pl73o5ui 95 6 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 95 7 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 95 8 target target NN work_wgf2msbacfaetpobn6pl73o5ui 95 9 mito mito NNP work_wgf2msbacfaetpobn6pl73o5ui 95 10 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 95 11 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 95 12 to to TO work_wgf2msbacfaetpobn6pl73o5ui 95 13 control control VB work_wgf2msbacfaetpobn6pl73o5ui 95 14 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 95 15 function function NN work_wgf2msbacfaetpobn6pl73o5ui 95 16 . . . work_wgf2msbacfaetpobn6pl73o5ui 96 1 H9c2 H9c2 NNP work_wgf2msbacfaetpobn6pl73o5ui 96 2 myoblast myoblast NN work_wgf2msbacfaetpobn6pl73o5ui 96 3 cells cell NNS work_wgf2msbacfaetpobn6pl73o5ui 96 4 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 96 5 transfected transfecte VBN work_wgf2msbacfaetpobn6pl73o5ui 96 6 with with IN work_wgf2msbacfaetpobn6pl73o5ui 96 7 a a DT work_wgf2msbacfaetpobn6pl73o5ui 96 8 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 96 9 matrix matrix NN work_wgf2msbacfaetpobn6pl73o5ui 96 10 targeted target VBD work_wgf2msbacfaetpobn6pl73o5ui 96 11 YFP YFP NNP work_wgf2msbacfaetpobn6pl73o5ui 96 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 96 13 then then RB work_wgf2msbacfaetpobn6pl73o5ui 96 14 loaded load VBN work_wgf2msbacfaetpobn6pl73o5ui 96 15 with with IN work_wgf2msbacfaetpobn6pl73o5ui 96 16 fura2 fura2 NN work_wgf2msbacfaetpobn6pl73o5ui 96 17 , , , work_wgf2msbacfaetpobn6pl73o5ui 96 18 to to TO work_wgf2msbacfaetpobn6pl73o5ui 96 19 monitor monitor VB work_wgf2msbacfaetpobn6pl73o5ui 96 20 the the DT work_wgf2msbacfaetpobn6pl73o5ui 96 21 mito mito NNP work_wgf2msbacfaetpobn6pl73o5ui 96 22 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 96 23 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 96 24 simultaneously simultaneously RB work_wgf2msbacfaetpobn6pl73o5ui 96 25 with with IN work_wgf2msbacfaetpobn6pl73o5ui 96 26 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 96 27 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 96 28 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 96 29 ] ] -RRB- work_wgf2msbacfaetpobn6pl73o5ui 96 30 c. c. NN work_wgf2msbacfaetpobn6pl73o5ui 96 31 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 96 32 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 96 33 100 100 CD work_wgf2msbacfaetpobn6pl73o5ui 96 34 mM mM NNP work_wgf2msbacfaetpobn6pl73o5ui 96 35 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 96 36 caused cause VBD work_wgf2msbacfaetpobn6pl73o5ui 96 37 a a DT work_wgf2msbacfaetpobn6pl73o5ui 96 38 decrease decrease NN work_wgf2msbacfaetpobn6pl73o5ui 96 39 in in IN work_wgf2msbacfaetpobn6pl73o5ui 96 40 mito mito NNP work_wgf2msbacfaetpobn6pl73o5ui 96 41 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 96 42 motility motility NNP work_wgf2msbacfaetpobn6pl73o5ui 96 43 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 96 44 6458 6458 CD work_wgf2msbacfaetpobn6pl73o5ui 96 45 % % NN work_wgf2msbacfaetpobn6pl73o5ui 96 46 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 96 47 and and CC work_wgf2msbacfaetpobn6pl73o5ui 96 48 an an DT work_wgf2msbacfaetpobn6pl73o5ui 96 49 elevation elevation NN work_wgf2msbacfaetpobn6pl73o5ui 96 50 in in IN work_wgf2msbacfaetpobn6pl73o5ui 96 51 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 96 52 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 96 53 2þ 2þ NNP work_wgf2msbacfaetpobn6pl73o5ui 96 54 ] ] -RRB- work_wgf2msbacfaetpobn6pl73o5ui 96 55 c c NN work_wgf2msbacfaetpobn6pl73o5ui 96 56 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 96 57 from from IN work_wgf2msbacfaetpobn6pl73o5ui 96 58 5558 5558 CD work_wgf2msbacfaetpobn6pl73o5ui 96 59 to to IN work_wgf2msbacfaetpobn6pl73o5ui 96 60 9158 9158 CD work_wgf2msbacfaetpobn6pl73o5ui 96 61 nM nM NNP work_wgf2msbacfaetpobn6pl73o5ui 96 62 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 96 63 at at IN work_wgf2msbacfaetpobn6pl73o5ui 96 64 the the DT work_wgf2msbacfaetpobn6pl73o5ui 96 65 same same JJ work_wgf2msbacfaetpobn6pl73o5ui 96 66 time time NN work_wgf2msbacfaetpobn6pl73o5ui 96 67 . . . work_wgf2msbacfaetpobn6pl73o5ui 97 1 When when WRB work_wgf2msbacfaetpobn6pl73o5ui 97 2 the the DT work_wgf2msbacfaetpobn6pl73o5ui 97 3 cells cell NNS work_wgf2msbacfaetpobn6pl73o5ui 97 4 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 97 5 incu- incu- NN work_wgf2msbacfaetpobn6pl73o5ui 97 6 bated bate VBN work_wgf2msbacfaetpobn6pl73o5ui 97 7 in in IN work_wgf2msbacfaetpobn6pl73o5ui 97 8 a a DT work_wgf2msbacfaetpobn6pl73o5ui 97 9 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 97 10 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 97 11 -free -free JJ work_wgf2msbacfaetpobn6pl73o5ui 97 12 medium medium NN work_wgf2msbacfaetpobn6pl73o5ui 97 13 and and CC work_wgf2msbacfaetpobn6pl73o5ui 97 14 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 97 15 pretreated pretreate VBN work_wgf2msbacfaetpobn6pl73o5ui 97 16 with with IN work_wgf2msbacfaetpobn6pl73o5ui 97 17 thapsigargin thapsigargin NN work_wgf2msbacfaetpobn6pl73o5ui 97 18 to to TO work_wgf2msbacfaetpobn6pl73o5ui 97 19 prevent prevent VB work_wgf2msbacfaetpobn6pl73o5ui 97 20 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 97 21 entry entry NN work_wgf2msbacfaetpobn6pl73o5ui 97 22 and and CC work_wgf2msbacfaetpobn6pl73o5ui 97 23 intracellular intracellular JJ work_wgf2msbacfaetpobn6pl73o5ui 97 24 Ca2þ ca2þ NN work_wgf2msbacfaetpobn6pl73o5ui 97 25 mobilization mobilization NN work_wgf2msbacfaetpobn6pl73o5ui 97 26 , , , work_wgf2msbacfaetpobn6pl73o5ui 97 27 respectively respectively RB work_wgf2msbacfaetpobn6pl73o5ui 97 28 , , , work_wgf2msbacfaetpobn6pl73o5ui 97 29 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 97 30 continued continue VBD work_wgf2msbacfaetpobn6pl73o5ui 97 31 to to TO work_wgf2msbacfaetpobn6pl73o5ui 97 32 inhibit inhibit VB work_wgf2msbacfaetpobn6pl73o5ui 97 33 the the DT work_wgf2msbacfaetpobn6pl73o5ui 97 34 mito mito NNP work_wgf2msbacfaetpobn6pl73o5ui 97 35 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 97 36 motility motility NNP work_wgf2msbacfaetpobn6pl73o5ui 97 37 dose dose NN work_wgf2msbacfaetpobn6pl73o5ui 97 38 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 97 39 dependently dependently RB work_wgf2msbacfaetpobn6pl73o5ui 97 40 without without IN work_wgf2msbacfaetpobn6pl73o5ui 97 41 any any DT work_wgf2msbacfaetpobn6pl73o5ui 97 42 changes change NNS work_wgf2msbacfaetpobn6pl73o5ui 97 43 in in IN work_wgf2msbacfaetpobn6pl73o5ui 97 44 [ [ -LRB- work_wgf2msbacfaetpobn6pl73o5ui 97 45 Ca2þ]c Ca2þ]c NNS work_wgf2msbacfaetpobn6pl73o5ui 97 46 . . . work_wgf2msbacfaetpobn6pl73o5ui 97 47 These these DT work_wgf2msbacfaetpobn6pl73o5ui 97 48 results result NNS work_wgf2msbacfaetpobn6pl73o5ui 97 49 indicate indicate VBP work_wgf2msbacfaetpobn6pl73o5ui 97 50 that that IN work_wgf2msbacfaetpobn6pl73o5ui 97 51 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 97 52 can can MD work_wgf2msbacfaetpobn6pl73o5ui 97 53 cause cause VB work_wgf2msbacfaetpobn6pl73o5ui 97 54 suppression suppression NN work_wgf2msbacfaetpobn6pl73o5ui 97 55 of of IN work_wgf2msbacfaetpobn6pl73o5ui 97 56 mito mito NNP work_wgf2msbacfaetpobn6pl73o5ui 97 57 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 97 58 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 97 59 through through IN work_wgf2msbacfaetpobn6pl73o5ui 97 60 a a DT work_wgf2msbacfaetpobn6pl73o5ui 97 61 Ca Ca NNP work_wgf2msbacfaetpobn6pl73o5ui 97 62 2þ 2þ CD work_wgf2msbacfaetpobn6pl73o5ui 97 63 independent independent JJ work_wgf2msbacfaetpobn6pl73o5ui 97 64 mechanism mechanism NN work_wgf2msbacfaetpobn6pl73o5ui 97 65 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 97 66 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 97 67 currently currently RB work_wgf2msbacfaetpobn6pl73o5ui 97 68 analyzing analyze VBG work_wgf2msbacfaetpobn6pl73o5ui 97 69 . . . work_wgf2msbacfaetpobn6pl73o5ui 98 1 3078-Pos 3078-Pos : work_wgf2msbacfaetpobn6pl73o5ui 98 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 98 3 B508 B508 NNP work_wgf2msbacfaetpobn6pl73o5ui 98 4 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 98 5 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 98 6 Dispensable dispensable JJ work_wgf2msbacfaetpobn6pl73o5ui 98 7 for for IN work_wgf2msbacfaetpobn6pl73o5ui 98 8 Calcium Calcium NNP work_wgf2msbacfaetpobn6pl73o5ui 98 9 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 98 10 Mediated mediate VBN work_wgf2msbacfaetpobn6pl73o5ui 98 11 Inhibition Inhibition NNP work_wgf2msbacfaetpobn6pl73o5ui 98 12 of of IN work_wgf2msbacfaetpobn6pl73o5ui 98 13 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 98 14 Movement Movement NNP work_wgf2msbacfaetpobn6pl73o5ui 98 15 David David NNP work_wgf2msbacfaetpobn6pl73o5ui 98 16 B. B. NNP work_wgf2msbacfaetpobn6pl73o5ui 98 17 Weaver1 Weaver1 NNP work_wgf2msbacfaetpobn6pl73o5ui 98 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 98 19 Agnieszka Agnieszka NNP work_wgf2msbacfaetpobn6pl73o5ui 98 20 Lewandowska2 Lewandowska2 NNP work_wgf2msbacfaetpobn6pl73o5ui 98 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 98 22 Tammy Tammy NNP work_wgf2msbacfaetpobn6pl73o5ui 98 23 T. T. NNP work_wgf2msbacfaetpobn6pl73o5ui 98 24 Nguyen2 Nguyen2 NNP work_wgf2msbacfaetpobn6pl73o5ui 98 25 , , , work_wgf2msbacfaetpobn6pl73o5ui 98 26 Valentina Valentina NNP work_wgf2msbacfaetpobn6pl73o5ui 98 27 Debattisti1 Debattisti1 NNP work_wgf2msbacfaetpobn6pl73o5ui 98 28 , , , work_wgf2msbacfaetpobn6pl73o5ui 98 29 Janet Janet NNP work_wgf2msbacfaetpobn6pl73o5ui 98 30 M. M. NNP work_wgf2msbacfaetpobn6pl73o5ui 98 31 Shaw2 Shaw2 NNS work_wgf2msbacfaetpobn6pl73o5ui 98 32 , , , work_wgf2msbacfaetpobn6pl73o5ui 98 33 Gyorgy Gyorgy NNP work_wgf2msbacfaetpobn6pl73o5ui 98 34 Hajnoczky1 Hajnoczky1 NNP work_wgf2msbacfaetpobn6pl73o5ui 98 35 . . . work_wgf2msbacfaetpobn6pl73o5ui 99 1 1MitoCare 1mitocare CD work_wgf2msbacfaetpobn6pl73o5ui 99 2 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 99 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 4 Dept Dept NNP work_wgf2msbacfaetpobn6pl73o5ui 99 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 99 6 Pathology Pathology NNP work_wgf2msbacfaetpobn6pl73o5ui 99 7 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 8 Anatomy Anatomy NNP work_wgf2msbacfaetpobn6pl73o5ui 99 9 and and CC work_wgf2msbacfaetpobn6pl73o5ui 99 10 Cell Cell NNP work_wgf2msbacfaetpobn6pl73o5ui 99 11 Biology Biology NNP work_wgf2msbacfaetpobn6pl73o5ui 99 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 13 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 99 14 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 99 15 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 99 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 17 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 99 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 19 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 99 20 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 21 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 99 22 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 23 2Biochemistry 2Biochemistry NNP work_wgf2msbacfaetpobn6pl73o5ui 99 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 25 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 99 26 of of IN work_wgf2msbacfaetpobn6pl73o5ui 99 27 Utah Utah NNP work_wgf2msbacfaetpobn6pl73o5ui 99 28 School School NNP work_wgf2msbacfaetpobn6pl73o5ui 99 29 of of IN work_wgf2msbacfaetpobn6pl73o5ui 99 30 Medicine Medicine NNP work_wgf2msbacfaetpobn6pl73o5ui 99 31 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 32 Salt Salt NNP work_wgf2msbacfaetpobn6pl73o5ui 99 33 Lake Lake NNP work_wgf2msbacfaetpobn6pl73o5ui 99 34 City City NNP work_wgf2msbacfaetpobn6pl73o5ui 99 35 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 36 UT UT NNP work_wgf2msbacfaetpobn6pl73o5ui 99 37 , , , work_wgf2msbacfaetpobn6pl73o5ui 99 38 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 99 39 . . . work_wgf2msbacfaetpobn6pl73o5ui 100 1 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 100 2 and and CC work_wgf2msbacfaetpobn6pl73o5ui 100 3 2 2 CD work_wgf2msbacfaetpobn6pl73o5ui 100 4 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 100 5 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 100 6 Rhot1 Rhot1 NNS work_wgf2msbacfaetpobn6pl73o5ui 100 7 and and CC work_wgf2msbacfaetpobn6pl73o5ui 100 8 2 2 CD work_wgf2msbacfaetpobn6pl73o5ui 100 9 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 100 10 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 100 11 two two CD work_wgf2msbacfaetpobn6pl73o5ui 100 12 highly highly RB work_wgf2msbacfaetpobn6pl73o5ui 100 13 similar similar JJ work_wgf2msbacfaetpobn6pl73o5ui 100 14 GTPases gtpase NNS work_wgf2msbacfaetpobn6pl73o5ui 100 15 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 100 16 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 100 17 bound bind VBN work_wgf2msbacfaetpobn6pl73o5ui 100 18 to to IN work_wgf2msbacfaetpobn6pl73o5ui 100 19 the the DT work_wgf2msbacfaetpobn6pl73o5ui 100 20 surface surface NN work_wgf2msbacfaetpobn6pl73o5ui 100 21 of of IN work_wgf2msbacfaetpobn6pl73o5ui 100 22 mitochondria mitochondrion NNS work_wgf2msbacfaetpobn6pl73o5ui 100 23 and and CC work_wgf2msbacfaetpobn6pl73o5ui 100 24 possess possess VB work_wgf2msbacfaetpobn6pl73o5ui 100 25 EF EF NNP work_wgf2msbacfaetpobn6pl73o5ui 100 26 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 100 27 hand hand NN work_wgf2msbacfaetpobn6pl73o5ui 100 28 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 100 29 binding bind VBG work_wgf2msbacfaetpobn6pl73o5ui 100 30 motifs motif NNS work_wgf2msbacfaetpobn6pl73o5ui 100 31 . . . work_wgf2msbacfaetpobn6pl73o5ui 101 1 Several several JJ work_wgf2msbacfaetpobn6pl73o5ui 101 2 groups group NNS work_wgf2msbacfaetpobn6pl73o5ui 101 3 have have VBP work_wgf2msbacfaetpobn6pl73o5ui 101 4 reported report VBN work_wgf2msbacfaetpobn6pl73o5ui 101 5 that that IN work_wgf2msbacfaetpobn6pl73o5ui 101 6 Miro Miro NNP work_wgf2msbacfaetpobn6pl73o5ui 101 7 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 101 8 involved involve VBN work_wgf2msbacfaetpobn6pl73o5ui 101 9 in in IN work_wgf2msbacfaetpobn6pl73o5ui 101 10 mitochondrial mitochondrial JJ work_wgf2msbacfaetpobn6pl73o5ui 101 11 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 101 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 101 13 inheritance inheritance NN work_wgf2msbacfaetpobn6pl73o5ui 101 14 , , , work_wgf2msbacfaetpobn6pl73o5ui 101 15 and and CC work_wgf2msbacfaetpobn6pl73o5ui 101 16 particularly particularly RB work_wgf2msbacfaetpobn6pl73o5ui 101 17 its -PRON- PRP$ work_wgf2msbacfaetpobn6pl73o5ui 101 18 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 101 19 regulation regulation NN work_wgf2msbacfaetpobn6pl73o5ui 101 20 , , , work_wgf2msbacfaetpobn6pl73o5ui 101 21 but but CC work_wgf2msbacfaetpobn6pl73o5ui 101 22 the the DT work_wgf2msbacfaetpobn6pl73o5ui 101 23 roles role NNS work_wgf2msbacfaetpobn6pl73o5ui 101 24 of of IN work_wgf2msbacfaetpobn6pl73o5ui 101 25 the the DT work_wgf2msbacfaetpobn6pl73o5ui 101 26 two two CD work_wgf2msbacfaetpobn6pl73o5ui 101 27 isoforms isoform NNS work_wgf2msbacfaetpobn6pl73o5ui 101 28 have have VBP work_wgf2msbacfaetpobn6pl73o5ui 101 29 not not RB work_wgf2msbacfaetpobn6pl73o5ui 101 30 been be VBN work_wgf2msbacfaetpobn6pl73o5ui 101 31 established establish VBN work_wgf2msbacfaetpobn6pl73o5ui 101 32 . . . work_wgf2msbacfaetpobn6pl73o5ui 102 1 Genetic genetic JJ work_wgf2msbacfaetpobn6pl73o5ui 102 2 deletion deletion NN work_wgf2msbacfaetpobn6pl73o5ui 102 3 of of IN work_wgf2msbacfaetpobn6pl73o5ui 102 4 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 102 5 in in IN work_wgf2msbacfaetpobn6pl73o5ui 102 6 mouse mouse NN work_wgf2msbacfaetpobn6pl73o5ui 102 7 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 102 8 lethal lethal JJ work_wgf2msbacfaetpobn6pl73o5ui 102 9 at at IN work_wgf2msbacfaetpobn6pl73o5ui 102 10 birth birth NN work_wgf2msbacfaetpobn6pl73o5ui 102 11 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 102 12 Nguyen Nguyen NNP work_wgf2msbacfaetpobn6pl73o5ui 102 13 et et NNP work_wgf2msbacfaetpobn6pl73o5ui 102 14 al al NNP work_wgf2msbacfaetpobn6pl73o5ui 102 15 . . NNP work_wgf2msbacfaetpobn6pl73o5ui 102 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 102 17 2014 2014 CD work_wgf2msbacfaetpobn6pl73o5ui 102 18 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 102 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 102 20 fibroblasts fibroblast NNS work_wgf2msbacfaetpobn6pl73o5ui 102 21 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 102 22 MEFs MEFs NNPS work_wgf2msbacfaetpobn6pl73o5ui 102 23 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 102 24 derived derive VBN work_wgf2msbacfaetpobn6pl73o5ui 102 25 from from IN work_wgf2msbacfaetpobn6pl73o5ui 102 26 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 102 27 KO KO NNP work_wgf2msbacfaetpobn6pl73o5ui 102 28 em- em- NNP work_wgf2msbacfaetpobn6pl73o5ui 102 29 bryos bryos NNP work_wgf2msbacfaetpobn6pl73o5ui 102 30 show show VBP work_wgf2msbacfaetpobn6pl73o5ui 102 31 abnormal abnormal JJ work_wgf2msbacfaetpobn6pl73o5ui 102 32 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 102 33 distribution distribution NN work_wgf2msbacfaetpobn6pl73o5ui 102 34 , , , work_wgf2msbacfaetpobn6pl73o5ui 102 35 but but CC work_wgf2msbacfaetpobn6pl73o5ui 102 36 the the DT work_wgf2msbacfaetpobn6pl73o5ui 102 37 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 102 38 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 102 39 dependent dependent JJ work_wgf2msbacfaetpobn6pl73o5ui 102 40 in- in- JJ work_wgf2msbacfaetpobn6pl73o5ui 102 41 hibition hibition NN work_wgf2msbacfaetpobn6pl73o5ui 102 42 of of IN work_wgf2msbacfaetpobn6pl73o5ui 102 43 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 102 44 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 102 45 unaffected unaffected JJ work_wgf2msbacfaetpobn6pl73o5ui 102 46 and and CC work_wgf2msbacfaetpobn6pl73o5ui 102 47 the the DT work_wgf2msbacfaetpobn6pl73o5ui 102 48 respiratory respiratory JJ work_wgf2msbacfaetpobn6pl73o5ui 102 49 and and CC work_wgf2msbacfaetpobn6pl73o5ui 102 50 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 102 51 buffering buffering NN work_wgf2msbacfaetpobn6pl73o5ui 102 52 capacities capacity NNS work_wgf2msbacfaetpobn6pl73o5ui 102 53 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 102 54 normal normal JJ work_wgf2msbacfaetpobn6pl73o5ui 102 55 . . . work_wgf2msbacfaetpobn6pl73o5ui 103 1 Neuron neuron NN work_wgf2msbacfaetpobn6pl73o5ui 103 2 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 103 3 specific specific JJ work_wgf2msbacfaetpobn6pl73o5ui 103 4 knockout knockout NN work_wgf2msbacfaetpobn6pl73o5ui 103 5 of of IN work_wgf2msbacfaetpobn6pl73o5ui 103 6 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 103 7 leads lead NNS work_wgf2msbacfaetpobn6pl73o5ui 103 8 to to IN work_wgf2msbacfaetpobn6pl73o5ui 103 9 progressive progressive JJ work_wgf2msbacfaetpobn6pl73o5ui 103 10 deficits deficit NNS work_wgf2msbacfaetpobn6pl73o5ui 103 11 of of IN work_wgf2msbacfaetpobn6pl73o5ui 103 12 upper upper JJ work_wgf2msbacfaetpobn6pl73o5ui 103 13 motor motor NNP work_wgf2msbacfaetpobn6pl73o5ui 103 14 neuron neuron NNP work_wgf2msbacfaetpobn6pl73o5ui 103 15 function function NN work_wgf2msbacfaetpobn6pl73o5ui 103 16 , , , work_wgf2msbacfaetpobn6pl73o5ui 103 17 however however RB work_wgf2msbacfaetpobn6pl73o5ui 103 18 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 103 19 in in IN work_wgf2msbacfaetpobn6pl73o5ui 103 20 processes process NNS work_wgf2msbacfaetpobn6pl73o5ui 103 21 of of IN work_wgf2msbacfaetpobn6pl73o5ui 103 22 cortical cortical JJ work_wgf2msbacfaetpobn6pl73o5ui 103 23 neurons neuron NNS work_wgf2msbacfaetpobn6pl73o5ui 103 24 from from IN work_wgf2msbacfaetpobn6pl73o5ui 103 25 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 103 26 KO KO NNP work_wgf2msbacfaetpobn6pl73o5ui 103 27 and and CC work_wgf2msbacfaetpobn6pl73o5ui 103 28 wild wild JJ work_wgf2msbacfaetpobn6pl73o5ui 103 29 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 103 30 type type NN work_wgf2msbacfaetpobn6pl73o5ui 103 31 embryos embryo NNS work_wgf2msbacfaetpobn6pl73o5ui 103 32 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 103 33 comparable comparable JJ work_wgf2msbacfaetpobn6pl73o5ui 103 34 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 103 35 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 103 36 sensitive sensitive JJ work_wgf2msbacfaetpobn6pl73o5ui 103 37 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 103 38 inhibition inhibition NN work_wgf2msbacfaetpobn6pl73o5ui 103 39 . . . work_wgf2msbacfaetpobn6pl73o5ui 104 1 While while IN work_wgf2msbacfaetpobn6pl73o5ui 104 2 no no DT work_wgf2msbacfaetpobn6pl73o5ui 104 3 significant significant JJ work_wgf2msbacfaetpobn6pl73o5ui 104 4 increase increase NN work_wgf2msbacfaetpobn6pl73o5ui 104 5 in in IN work_wgf2msbacfaetpobn6pl73o5ui 104 6 Miro2 miro2 JJ work_wgf2msbacfaetpobn6pl73o5ui 104 7 pro- pro- NN work_wgf2msbacfaetpobn6pl73o5ui 104 8 tein tein NN work_wgf2msbacfaetpobn6pl73o5ui 104 9 was be VBD work_wgf2msbacfaetpobn6pl73o5ui 104 10 observed observe VBN work_wgf2msbacfaetpobn6pl73o5ui 104 11 in in IN work_wgf2msbacfaetpobn6pl73o5ui 104 12 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 104 13 KO KO NNP work_wgf2msbacfaetpobn6pl73o5ui 104 14 MEFs MEFs NNPS work_wgf2msbacfaetpobn6pl73o5ui 104 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 104 16 these these DT work_wgf2msbacfaetpobn6pl73o5ui 104 17 data datum NNS work_wgf2msbacfaetpobn6pl73o5ui 104 18 raise raise VBP work_wgf2msbacfaetpobn6pl73o5ui 104 19 two two CD work_wgf2msbacfaetpobn6pl73o5ui 104 20 possibilities possibility NNS work_wgf2msbacfaetpobn6pl73o5ui 104 21 : : : work_wgf2msbacfaetpobn6pl73o5ui 104 22 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 104 23 and and CC work_wgf2msbacfaetpobn6pl73o5ui 104 24 2 2 CD work_wgf2msbacfaetpobn6pl73o5ui 104 25 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 104 26 interchangeable interchangeable JJ work_wgf2msbacfaetpobn6pl73o5ui 104 27 with with IN work_wgf2msbacfaetpobn6pl73o5ui 104 28 regard regard NN work_wgf2msbacfaetpobn6pl73o5ui 104 29 to to IN work_wgf2msbacfaetpobn6pl73o5ui 104 30 calcium calcium NN work_wgf2msbacfaetpobn6pl73o5ui 104 31 regulation regulation NN work_wgf2msbacfaetpobn6pl73o5ui 104 32 of of IN work_wgf2msbacfaetpobn6pl73o5ui 104 33 mitochondrial mitochondrial JJ work_wgf2msbacfaetpobn6pl73o5ui 104 34 motility motility NN work_wgf2msbacfaetpobn6pl73o5ui 104 35 or or CC work_wgf2msbacfaetpobn6pl73o5ui 104 36 Miro2 miro2 NN work_wgf2msbacfaetpobn6pl73o5ui 104 37 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 104 38 the the DT work_wgf2msbacfaetpobn6pl73o5ui 104 39 key key JJ work_wgf2msbacfaetpobn6pl73o5ui 104 40 player player NN work_wgf2msbacfaetpobn6pl73o5ui 104 41 in in IN work_wgf2msbacfaetpobn6pl73o5ui 104 42 this this DT work_wgf2msbacfaetpobn6pl73o5ui 104 43 regard regard NN work_wgf2msbacfaetpobn6pl73o5ui 104 44 . . . work_wgf2msbacfaetpobn6pl73o5ui 105 1 To to TO work_wgf2msbacfaetpobn6pl73o5ui 105 2 finally finally RB work_wgf2msbacfaetpobn6pl73o5ui 105 3 resolve resolve VB work_wgf2msbacfaetpobn6pl73o5ui 105 4 this this DT work_wgf2msbacfaetpobn6pl73o5ui 105 5 question question NN work_wgf2msbacfaetpobn6pl73o5ui 105 6 , , , work_wgf2msbacfaetpobn6pl73o5ui 105 7 we -PRON- PRP work_wgf2msbacfaetpobn6pl73o5ui 105 8 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 105 9 in in IN work_wgf2msbacfaetpobn6pl73o5ui 105 10 the the DT work_wgf2msbacfaetpobn6pl73o5ui 105 11 process process NN work_wgf2msbacfaetpobn6pl73o5ui 105 12 of of IN work_wgf2msbacfaetpobn6pl73o5ui 105 13 generating generate VBG work_wgf2msbacfaetpobn6pl73o5ui 105 14 Miro2 miro2 CD work_wgf2msbacfaetpobn6pl73o5ui 105 15 KO KO NNP work_wgf2msbacfaetpobn6pl73o5ui 105 16 and and CC work_wgf2msbacfaetpobn6pl73o5ui 105 17 Miro1/2 Miro1/2 NNP work_wgf2msbacfaetpobn6pl73o5ui 105 18 KO KO NNP work_wgf2msbacfaetpobn6pl73o5ui 105 19 cell cell NN work_wgf2msbacfaetpobn6pl73o5ui 105 20 lines line NNS work_wgf2msbacfaetpobn6pl73o5ui 105 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 106 1 3079-Pos 3079-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 106 2 Board Board NNP work_wgf2msbacfaetpobn6pl73o5ui 106 3 B509 B509 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 4 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 106 5 Fusion Fusion NNP work_wgf2msbacfaetpobn6pl73o5ui 106 6 Dynamics Dynamics NNPS work_wgf2msbacfaetpobn6pl73o5ui 106 7 in in IN work_wgf2msbacfaetpobn6pl73o5ui 106 8 the the DT work_wgf2msbacfaetpobn6pl73o5ui 106 9 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 106 10 Veronica Veronica NNP work_wgf2msbacfaetpobn6pl73o5ui 106 11 Eisner1 Eisner1 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 13 Ryan Ryan NNP work_wgf2msbacfaetpobn6pl73o5ui 106 14 Cupo1 Cupo1 NNS work_wgf2msbacfaetpobn6pl73o5ui 106 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 16 Erhe Erhe NNP work_wgf2msbacfaetpobn6pl73o5ui 106 17 Gao2 Gao2 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 19 György György NNP work_wgf2msbacfaetpobn6pl73o5ui 106 20 Csordás1 csordás1 ADD work_wgf2msbacfaetpobn6pl73o5ui 106 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 22 Lan Lan NNP work_wgf2msbacfaetpobn6pl73o5ui 106 23 Cheng3 Cheng3 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 25 Jessica Jessica NNP work_wgf2msbacfaetpobn6pl73o5ui 106 26 Ibetti2 Ibetti2 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 27 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 28 J. J. NNP work_wgf2msbacfaetpobn6pl73o5ui 106 29 Kurt Kurt NNP work_wgf2msbacfaetpobn6pl73o5ui 106 30 Chuprun2 Chuprun2 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 31 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 32 Walter Walter NNP work_wgf2msbacfaetpobn6pl73o5ui 106 33 J. J. NNP work_wgf2msbacfaetpobn6pl73o5ui 106 34 Koch2 koch2 NN work_wgf2msbacfaetpobn6pl73o5ui 106 35 , , , work_wgf2msbacfaetpobn6pl73o5ui 106 36 György György NNP work_wgf2msbacfaetpobn6pl73o5ui 106 37 Hajnóczky1 Hajnóczky1 NNP work_wgf2msbacfaetpobn6pl73o5ui 106 38 . . . work_wgf2msbacfaetpobn6pl73o5ui 107 1 1MitoCare 1mitocare CD work_wgf2msbacfaetpobn6pl73o5ui 107 2 Center Center NNP work_wgf2msbacfaetpobn6pl73o5ui 107 3 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 4 Pathology Pathology NNP work_wgf2msbacfaetpobn6pl73o5ui 107 5 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 6 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 107 7 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 107 8 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 107 9 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 10 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 107 11 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 12 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 107 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 14 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 107 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 16 2Center 2Center NNP work_wgf2msbacfaetpobn6pl73o5ui 107 17 for for IN work_wgf2msbacfaetpobn6pl73o5ui 107 18 Translational Translational NNP work_wgf2msbacfaetpobn6pl73o5ui 107 19 Medicine Medicine NNP work_wgf2msbacfaetpobn6pl73o5ui 107 20 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 21 Temple Temple NNP work_wgf2msbacfaetpobn6pl73o5ui 107 22 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 107 23 School School NNP work_wgf2msbacfaetpobn6pl73o5ui 107 24 of of IN work_wgf2msbacfaetpobn6pl73o5ui 107 25 Medicine Medicine NNP work_wgf2msbacfaetpobn6pl73o5ui 107 26 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 27 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 107 28 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 29 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 107 30 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 31 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 107 32 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 33 3Center 3Center NNP work_wgf2msbacfaetpobn6pl73o5ui 107 34 for for IN work_wgf2msbacfaetpobn6pl73o5ui 107 35 Translational Translational NNP work_wgf2msbacfaetpobn6pl73o5ui 107 36 Medicine Medicine NNP work_wgf2msbacfaetpobn6pl73o5ui 107 37 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 38 Thomas Thomas NNP work_wgf2msbacfaetpobn6pl73o5ui 107 39 Jefferson Jefferson NNP work_wgf2msbacfaetpobn6pl73o5ui 107 40 University University NNP work_wgf2msbacfaetpobn6pl73o5ui 107 41 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 42 Philadelphia Philadelphia NNP work_wgf2msbacfaetpobn6pl73o5ui 107 43 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 44 PA PA NNP work_wgf2msbacfaetpobn6pl73o5ui 107 45 , , , work_wgf2msbacfaetpobn6pl73o5ui 107 46 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 107 47 . . . work_wgf2msbacfaetpobn6pl73o5ui 108 1 Heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 108 2 physiology physiology NN work_wgf2msbacfaetpobn6pl73o5ui 108 3 depends depend VBZ work_wgf2msbacfaetpobn6pl73o5ui 108 4 on on IN work_wgf2msbacfaetpobn6pl73o5ui 108 5 oxidative oxidative JJ work_wgf2msbacfaetpobn6pl73o5ui 108 6 metabolism metabolism NN work_wgf2msbacfaetpobn6pl73o5ui 108 7 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 108 8 likely likely RB work_wgf2msbacfaetpobn6pl73o5ui 108 9 requires require VBZ work_wgf2msbacfaetpobn6pl73o5ui 108 10 dy- dy- PRP work_wgf2msbacfaetpobn6pl73o5ui 108 11 namic namic JJ work_wgf2msbacfaetpobn6pl73o5ui 108 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 108 13 permanent permanent JJ work_wgf2msbacfaetpobn6pl73o5ui 108 14 reorganization reorganization NN work_wgf2msbacfaetpobn6pl73o5ui 108 15 of of IN work_wgf2msbacfaetpobn6pl73o5ui 108 16 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 108 17 by by IN work_wgf2msbacfaetpobn6pl73o5ui 108 18 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 108 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 108 20 fission fission NN work_wgf2msbacfaetpobn6pl73o5ui 108 21 . . . work_wgf2msbacfaetpobn6pl73o5ui 109 1 To to TO work_wgf2msbacfaetpobn6pl73o5ui 109 2 directly directly RB work_wgf2msbacfaetpobn6pl73o5ui 109 3 evaluate evaluate VB work_wgf2msbacfaetpobn6pl73o5ui 109 4 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 109 5 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 109 6 dynamics dynamic NNS work_wgf2msbacfaetpobn6pl73o5ui 109 7 in in IN work_wgf2msbacfaetpobn6pl73o5ui 109 8 cardiomyocytes cardiomyocyte NNS work_wgf2msbacfaetpobn6pl73o5ui 109 9 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 109 10 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 109 11 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 109 12 , , , work_wgf2msbacfaetpobn6pl73o5ui 109 13 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 109 14 matrix matrix NN work_wgf2msbacfaetpobn6pl73o5ui 109 15 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 109 16 targeted target VBN work_wgf2msbacfaetpobn6pl73o5ui 109 17 photoactivatable photoactivatable JJ work_wgf2msbacfaetpobn6pl73o5ui 109 18 GFP GFP NNP work_wgf2msbacfaetpobn6pl73o5ui 109 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 109 20 DsRed DsRed NNP work_wgf2msbacfaetpobn6pl73o5ui 109 21 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 109 22 intro- intro- NN work_wgf2msbacfaetpobn6pl73o5ui 109 23 duced duce VBN work_wgf2msbacfaetpobn6pl73o5ui 109 24 either either CC work_wgf2msbacfaetpobn6pl73o5ui 109 25 in in IN work_wgf2msbacfaetpobn6pl73o5ui 109 26 vitro vitro FW work_wgf2msbacfaetpobn6pl73o5ui 109 27 or or CC work_wgf2msbacfaetpobn6pl73o5ui 109 28 in in IN work_wgf2msbacfaetpobn6pl73o5ui 109 29 vivo vivo NNP work_wgf2msbacfaetpobn6pl73o5ui 109 30 by by IN work_wgf2msbacfaetpobn6pl73o5ui 109 31 adenovirus adenovirus NN work_wgf2msbacfaetpobn6pl73o5ui 109 32 and and CC work_wgf2msbacfaetpobn6pl73o5ui 109 33 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 109 34 followed follow VBN work_wgf2msbacfaetpobn6pl73o5ui 109 35 by by IN work_wgf2msbacfaetpobn6pl73o5ui 109 36 confocal confocal JJ work_wgf2msbacfaetpobn6pl73o5ui 109 37 microscopy microscopy NN work_wgf2msbacfaetpobn6pl73o5ui 109 38 . . . work_wgf2msbacfaetpobn6pl73o5ui 110 1 Four four CD work_wgf2msbacfaetpobn6pl73o5ui 110 2 conditions condition NNS work_wgf2msbacfaetpobn6pl73o5ui 110 3 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 110 4 analyzed analyze VBN work_wgf2msbacfaetpobn6pl73o5ui 110 5 : : : work_wgf2msbacfaetpobn6pl73o5ui 110 6 24 24 CD work_wgf2msbacfaetpobn6pl73o5ui 110 7 to to TO work_wgf2msbacfaetpobn6pl73o5ui 110 8 48 48 CD work_wgf2msbacfaetpobn6pl73o5ui 110 9 h h NN work_wgf2msbacfaetpobn6pl73o5ui 110 10 cultured cultured IN work_wgf2msbacfaetpobn6pl73o5ui 110 11 neonatal neonatal NN work_wgf2msbacfaetpobn6pl73o5ui 110 12 and and CC work_wgf2msbacfaetpobn6pl73o5ui 110 13 in in FW work_wgf2msbacfaetpobn6pl73o5ui 110 14 vitro vitro FW work_wgf2msbacfaetpobn6pl73o5ui 110 15 transduced transduce VBN work_wgf2msbacfaetpobn6pl73o5ui 110 16 adult adult NN work_wgf2msbacfaetpobn6pl73o5ui 110 17 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 110 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 110 19 and and CC work_wgf2msbacfaetpobn6pl73o5ui 110 20 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 110 21 from from IN work_wgf2msbacfaetpobn6pl73o5ui 110 22 in in IN work_wgf2msbacfaetpobn6pl73o5ui 110 23 vivo vivo NNP work_wgf2msbacfaetpobn6pl73o5ui 110 24 infected infected JJ work_wgf2msbacfaetpobn6pl73o5ui 110 25 rat rat NNP work_wgf2msbacfaetpobn6pl73o5ui 110 26 hearts heart NNS work_wgf2msbacfaetpobn6pl73o5ui 110 27 . . . work_wgf2msbacfaetpobn6pl73o5ui 111 1 In in IN work_wgf2msbacfaetpobn6pl73o5ui 111 2 the the DT work_wgf2msbacfaetpobn6pl73o5ui 111 3 latter latter JJ work_wgf2msbacfaetpobn6pl73o5ui 111 4 case case NN work_wgf2msbacfaetpobn6pl73o5ui 111 5 , , , work_wgf2msbacfaetpobn6pl73o5ui 111 6 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 111 7 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 111 8 isolated isolate VBN work_wgf2msbacfaetpobn6pl73o5ui 111 9 7 7 CD work_wgf2msbacfaetpobn6pl73o5ui 111 10 - - SYM work_wgf2msbacfaetpobn6pl73o5ui 111 11 10 10 CD work_wgf2msbacfaetpobn6pl73o5ui 111 12 days day NNS work_wgf2msbacfaetpobn6pl73o5ui 111 13 after after IN work_wgf2msbacfaetpobn6pl73o5ui 111 14 infection infection NN work_wgf2msbacfaetpobn6pl73o5ui 111 15 and and CC work_wgf2msbacfaetpobn6pl73o5ui 111 16 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 111 17 imaged image VBN work_wgf2msbacfaetpobn6pl73o5ui 111 18 promptly promptly RB work_wgf2msbacfaetpobn6pl73o5ui 111 19 or or CC work_wgf2msbacfaetpobn6pl73o5ui 111 20 24 24 CD work_wgf2msbacfaetpobn6pl73o5ui 111 21 - - SYM work_wgf2msbacfaetpobn6pl73o5ui 111 22 48 48 CD work_wgf2msbacfaetpobn6pl73o5ui 111 23 h h NN work_wgf2msbacfaetpobn6pl73o5ui 111 24 post post NN work_wgf2msbacfaetpobn6pl73o5ui 111 25 harvesting harvesting NN work_wgf2msbacfaetpobn6pl73o5ui 111 26 . . . work_wgf2msbacfaetpobn6pl73o5ui 112 1 Neonatal Neonatal NNP work_wgf2msbacfaetpobn6pl73o5ui 112 2 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 112 3 mitochondria mitochondrion NNS work_wgf2msbacfaetpobn6pl73o5ui 112 4 form form VBP work_wgf2msbacfaetpobn6pl73o5ui 112 5 a a DT work_wgf2msbacfaetpobn6pl73o5ui 112 6 highly highly RB work_wgf2msbacfaetpobn6pl73o5ui 112 7 connected connected JJ work_wgf2msbacfaetpobn6pl73o5ui 112 8 network network NN work_wgf2msbacfaetpobn6pl73o5ui 112 9 , , , work_wgf2msbacfaetpobn6pl73o5ui 112 10 whereas whereas IN work_wgf2msbacfaetpobn6pl73o5ui 112 11 both both DT work_wgf2msbacfaetpobn6pl73o5ui 112 12 in in IN work_wgf2msbacfaetpobn6pl73o5ui 112 13 vitro vitro FW work_wgf2msbacfaetpobn6pl73o5ui 112 14 and and CC work_wgf2msbacfaetpobn6pl73o5ui 112 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 112 16 vivo vivo NNP work_wgf2msbacfaetpobn6pl73o5ui 112 17 transformed transform VBN work_wgf2msbacfaetpobn6pl73o5ui 112 18 cultured cultured IN work_wgf2msbacfaetpobn6pl73o5ui 112 19 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 112 20 displayed display VBD work_wgf2msbacfaetpobn6pl73o5ui 112 21 only only RB work_wgf2msbacfaetpobn6pl73o5ui 112 22 some some DT work_wgf2msbacfaetpobn6pl73o5ui 112 23 connectivity connectivity NN work_wgf2msbacfaetpobn6pl73o5ui 112 24 . . . work_wgf2msbacfaetpobn6pl73o5ui 113 1 Impressively impressively RB work_wgf2msbacfaetpobn6pl73o5ui 113 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 113 3 in in IN work_wgf2msbacfaetpobn6pl73o5ui 113 4 vivo vivo NNP work_wgf2msbacfaetpobn6pl73o5ui 113 5 transduced transduce VBD work_wgf2msbacfaetpobn6pl73o5ui 113 6 adult adult NN work_wgf2msbacfaetpobn6pl73o5ui 113 7 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 113 8 that that WDT work_wgf2msbacfaetpobn6pl73o5ui 113 9 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 113 10 imaged image VBN work_wgf2msbacfaetpobn6pl73o5ui 113 11 promptly promptly RB work_wgf2msbacfaetpobn6pl73o5ui 113 12 after after IN work_wgf2msbacfaetpobn6pl73o5ui 113 13 harvesting harvesting NN work_wgf2msbacfaetpobn6pl73o5ui 113 14 , , , work_wgf2msbacfaetpobn6pl73o5ui 113 15 unveiled unveil VBD work_wgf2msbacfaetpobn6pl73o5ui 113 16 a a DT work_wgf2msbacfaetpobn6pl73o5ui 113 17 significantly significantly RB work_wgf2msbacfaetpobn6pl73o5ui 113 18 higher high JJR work_wgf2msbacfaetpobn6pl73o5ui 113 19 con- con- NN work_wgf2msbacfaetpobn6pl73o5ui 113 20 nectivity nectivity NN work_wgf2msbacfaetpobn6pl73o5ui 113 21 among among IN work_wgf2msbacfaetpobn6pl73o5ui 113 22 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 113 23 than than IN work_wgf2msbacfaetpobn6pl73o5ui 113 24 the the DT work_wgf2msbacfaetpobn6pl73o5ui 113 25 24 24 CD work_wgf2msbacfaetpobn6pl73o5ui 113 26 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 113 27 48h 48h NNS work_wgf2msbacfaetpobn6pl73o5ui 113 28 cultured cultured JJ work_wgf2msbacfaetpobn6pl73o5ui 113 29 adult adult NN work_wgf2msbacfaetpobn6pl73o5ui 113 30 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 113 31 . . . work_wgf2msbacfaetpobn6pl73o5ui 114 1 Furthermore furthermore RB work_wgf2msbacfaetpobn6pl73o5ui 114 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 114 3 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 114 4 events event NNS work_wgf2msbacfaetpobn6pl73o5ui 114 5 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 114 6 f.e./75 f.e./75 IN work_wgf2msbacfaetpobn6pl73o5ui 114 7 square square JJ work_wgf2msbacfaetpobn6pl73o5ui 114 8 micrometers micrometer NNS work_wgf2msbacfaetpobn6pl73o5ui 114 9 / / SYM work_wgf2msbacfaetpobn6pl73o5ui 114 10 min min NNP work_wgf2msbacfaetpobn6pl73o5ui 114 11 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 114 12 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 114 13 almost almost RB work_wgf2msbacfaetpobn6pl73o5ui 114 14 absent absent JJ work_wgf2msbacfaetpobn6pl73o5ui 114 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 114 16 cultured cultured JJ work_wgf2msbacfaetpobn6pl73o5ui 114 17 in in IN work_wgf2msbacfaetpobn6pl73o5ui 114 18 vitro vitro FW work_wgf2msbacfaetpobn6pl73o5ui 114 19 transduced transduced NNP work_wgf2msbacfaetpobn6pl73o5ui 114 20 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 114 21 , , , work_wgf2msbacfaetpobn6pl73o5ui 114 22 meanwhile meanwhile RB work_wgf2msbacfaetpobn6pl73o5ui 114 23 in in IN work_wgf2msbacfaetpobn6pl73o5ui 114 24 vivo vivo NNP work_wgf2msbacfaetpobn6pl73o5ui 114 25 transduced transduced NNP work_wgf2msbacfaetpobn6pl73o5ui 114 26 and and CC work_wgf2msbacfaetpobn6pl73o5ui 114 27 cultured cultured JJ work_wgf2msbacfaetpobn6pl73o5ui 114 28 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 114 29 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 114 30 0.450.2 0.450.2 NNP work_wgf2msbacfaetpobn6pl73o5ui 114 31 f.e./min f.e./min LS work_wgf2msbacfaetpobn6pl73o5ui 114 32 , , , work_wgf2msbacfaetpobn6pl73o5ui 114 33 whereas whereas IN work_wgf2msbacfaetpobn6pl73o5ui 114 34 isolated isolated JJ work_wgf2msbacfaetpobn6pl73o5ui 114 35 , , , work_wgf2msbacfaetpobn6pl73o5ui 114 36 freshly freshly RB work_wgf2msbacfaetpobn6pl73o5ui 114 37 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 114 38 imaged image VBN work_wgf2msbacfaetpobn6pl73o5ui 114 39 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 114 40 displayed display VBD work_wgf2msbacfaetpobn6pl73o5ui 114 41 1.45 1.45 CD work_wgf2msbacfaetpobn6pl73o5ui 114 42 0.1 0.1 CD work_wgf2msbacfaetpobn6pl73o5ui 114 43 f.e./min f.e./min NNS work_wgf2msbacfaetpobn6pl73o5ui 114 44 . . . work_wgf2msbacfaetpobn6pl73o5ui 115 1 Imaging image VBG work_wgf2msbacfaetpobn6pl73o5ui 115 2 in in IN work_wgf2msbacfaetpobn6pl73o5ui 115 3 perfused perfuse VBN work_wgf2msbacfaetpobn6pl73o5ui 115 4 whole whole JJ work_wgf2msbacfaetpobn6pl73o5ui 115 5 heart heart NN work_wgf2msbacfaetpobn6pl73o5ui 115 6 ex ex NNP work_wgf2msbacfaetpobn6pl73o5ui 115 7 vivo vivo NNP work_wgf2msbacfaetpobn6pl73o5ui 115 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 115 9 showed show VBD work_wgf2msbacfaetpobn6pl73o5ui 115 10 consider- consider- JJ work_wgf2msbacfaetpobn6pl73o5ui 115 11 able able JJ work_wgf2msbacfaetpobn6pl73o5ui 115 12 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 115 13 continuity continuity NN work_wgf2msbacfaetpobn6pl73o5ui 115 14 and and CC work_wgf2msbacfaetpobn6pl73o5ui 115 15 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 115 16 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 115 17 in in IN work_wgf2msbacfaetpobn6pl73o5ui 115 18 ventricular ventricular JJ work_wgf2msbacfaetpobn6pl73o5ui 115 19 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 115 20 . . . work_wgf2msbacfaetpobn6pl73o5ui 116 1 To to TO work_wgf2msbacfaetpobn6pl73o5ui 116 2 study study VB work_wgf2msbacfaetpobn6pl73o5ui 116 3 more more RBR work_wgf2msbacfaetpobn6pl73o5ui 116 4 directly directly RB work_wgf2msbacfaetpobn6pl73o5ui 116 5 the the DT work_wgf2msbacfaetpobn6pl73o5ui 116 6 role role NN work_wgf2msbacfaetpobn6pl73o5ui 116 7 of of IN work_wgf2msbacfaetpobn6pl73o5ui 116 8 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 116 9 ’s ’s POS work_wgf2msbacfaetpobn6pl73o5ui 116 10 contractile contractile NN work_wgf2msbacfaetpobn6pl73o5ui 116 11 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 116 12 in in IN work_wgf2msbacfaetpobn6pl73o5ui 116 13 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 116 14 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 116 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 116 16 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 116 17 were be VBD work_wgf2msbacfaetpobn6pl73o5ui 116 18 incubated incubate VBN work_wgf2msbacfaetpobn6pl73o5ui 116 19 with with IN work_wgf2msbacfaetpobn6pl73o5ui 116 20 Verapamil Verapamil NNP work_wgf2msbacfaetpobn6pl73o5ui 116 21 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 116 22 10mM 10mm CD work_wgf2msbacfaetpobn6pl73o5ui 116 23 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 116 24 , , , work_wgf2msbacfaetpobn6pl73o5ui 116 25 that that DT work_wgf2msbacfaetpobn6pl73o5ui 116 26 blocked block VBD work_wgf2msbacfaetpobn6pl73o5ui 116 27 spontaneous spontaneous JJ work_wgf2msbacfaetpobn6pl73o5ui 116 28 contrac- contrac- NN work_wgf2msbacfaetpobn6pl73o5ui 116 29 tion tion NN work_wgf2msbacfaetpobn6pl73o5ui 116 30 and and CC work_wgf2msbacfaetpobn6pl73o5ui 116 31 partially partially RB work_wgf2msbacfaetpobn6pl73o5ui 116 32 suppressed suppress VBD work_wgf2msbacfaetpobn6pl73o5ui 116 33 the the DT work_wgf2msbacfaetpobn6pl73o5ui 116 34 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 116 35 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 116 36 of of IN work_wgf2msbacfaetpobn6pl73o5ui 116 37 mitochondria mitochondria NNP work_wgf2msbacfaetpobn6pl73o5ui 116 38 . . . work_wgf2msbacfaetpobn6pl73o5ui 117 1 Also also RB work_wgf2msbacfaetpobn6pl73o5ui 117 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 117 3 mito- mito- NNP work_wgf2msbacfaetpobn6pl73o5ui 117 4 chondrial chondrial JJ work_wgf2msbacfaetpobn6pl73o5ui 117 5 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 117 6 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 117 7 appeared appear VBD work_wgf2msbacfaetpobn6pl73o5ui 117 8 to to TO work_wgf2msbacfaetpobn6pl73o5ui 117 9 be be VB work_wgf2msbacfaetpobn6pl73o5ui 117 10 higher high JJR work_wgf2msbacfaetpobn6pl73o5ui 117 11 after after IN work_wgf2msbacfaetpobn6pl73o5ui 117 12 spontaneous spontaneous JJ work_wgf2msbacfaetpobn6pl73o5ui 117 13 contraction contraction NN work_wgf2msbacfaetpobn6pl73o5ui 117 14 or or CC work_wgf2msbacfaetpobn6pl73o5ui 117 15 short short JJ work_wgf2msbacfaetpobn6pl73o5ui 117 16 term term NN work_wgf2msbacfaetpobn6pl73o5ui 117 17 field field NN work_wgf2msbacfaetpobn6pl73o5ui 117 18 stimulation stimulation NN work_wgf2msbacfaetpobn6pl73o5ui 117 19 in in IN work_wgf2msbacfaetpobn6pl73o5ui 117 20 isolated isolate VBN work_wgf2msbacfaetpobn6pl73o5ui 117 21 freshly freshly RB work_wgf2msbacfaetpobn6pl73o5ui 117 22 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 117 23 imaged image VBN work_wgf2msbacfaetpobn6pl73o5ui 117 24 CM cm NN work_wgf2msbacfaetpobn6pl73o5ui 117 25 . . . work_wgf2msbacfaetpobn6pl73o5ui 118 1 Thus thus RB work_wgf2msbacfaetpobn6pl73o5ui 118 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 118 3 mitochon- mitochon- NNP work_wgf2msbacfaetpobn6pl73o5ui 118 4 dria dria NN work_wgf2msbacfaetpobn6pl73o5ui 118 5 are be VBP work_wgf2msbacfaetpobn6pl73o5ui 118 6 dynamic dynamic JJ work_wgf2msbacfaetpobn6pl73o5ui 118 7 in in IN work_wgf2msbacfaetpobn6pl73o5ui 118 8 both both CC work_wgf2msbacfaetpobn6pl73o5ui 118 9 neonatal neonatal NN work_wgf2msbacfaetpobn6pl73o5ui 118 10 and and CC work_wgf2msbacfaetpobn6pl73o5ui 118 11 adult adult NN work_wgf2msbacfaetpobn6pl73o5ui 118 12 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 118 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 118 14 but but CC work_wgf2msbacfaetpobn6pl73o5ui 118 15 under under IN work_wgf2msbacfaetpobn6pl73o5ui 118 16 culture culture NN work_wgf2msbacfaetpobn6pl73o5ui 118 17 conditions condition NNS work_wgf2msbacfaetpobn6pl73o5ui 118 18 , , , work_wgf2msbacfaetpobn6pl73o5ui 118 19 adult adult NN work_wgf2msbacfaetpobn6pl73o5ui 118 20 CM CM NNP work_wgf2msbacfaetpobn6pl73o5ui 118 21 lose lose JJ work_wgf2msbacfaetpobn6pl73o5ui 118 22 mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 118 23 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 118 24 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 118 25 . . . work_wgf2msbacfaetpobn6pl73o5ui 119 1 This this DT work_wgf2msbacfaetpobn6pl73o5ui 119 2 might may MD work_wgf2msbacfaetpobn6pl73o5ui 119 3 be be VB work_wgf2msbacfaetpobn6pl73o5ui 119 4 at at IN work_wgf2msbacfaetpobn6pl73o5ui 119 5 least least JJS work_wgf2msbacfaetpobn6pl73o5ui 119 6 in in IN work_wgf2msbacfaetpobn6pl73o5ui 119 7 part part NN work_wgf2msbacfaetpobn6pl73o5ui 119 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 119 9 because because IN work_wgf2msbacfaetpobn6pl73o5ui 119 10 cardiomyocyte cardiomyocyte NNP work_wgf2msbacfaetpobn6pl73o5ui 119 11 contractile contractile NN work_wgf2msbacfaetpobn6pl73o5ui 119 12 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 119 13 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 119 14 altered alter VBN work_wgf2msbacfaetpobn6pl73o5ui 119 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 119 16 culture culture NN work_wgf2msbacfaetpobn6pl73o5ui 119 17 and and CC work_wgf2msbacfaetpobn6pl73o5ui 119 18 contractions contraction NNS work_wgf2msbacfaetpobn6pl73o5ui 119 19 likely likely RB work_wgf2msbacfaetpobn6pl73o5ui 119 20 provide provide VBP work_wgf2msbacfaetpobn6pl73o5ui 119 21 some some DT work_wgf2msbacfaetpobn6pl73o5ui 119 22 factors factor NNS work_wgf2msbacfaetpobn6pl73o5ui 119 23 to to TO work_wgf2msbacfaetpobn6pl73o5ui 119 24 support support VB work_wgf2msbacfaetpobn6pl73o5ui 119 25 mitochondrial mitochondrial JJ work_wgf2msbacfaetpobn6pl73o5ui 119 26 fusion fusion NN work_wgf2msbacfaetpobn6pl73o5ui 119 27 activity activity NN work_wgf2msbacfaetpobn6pl73o5ui 119 28 . . . work_wgf2msbacfaetpobn6pl73o5ui 120 1 3080-Pos 3080-Pos NFP work_wgf2msbacfaetpobn6pl73o5ui 120 2 Board board NN work_wgf2msbacfaetpobn6pl73o5ui 120 3 B510 B510 NNP work_wgf2msbacfaetpobn6pl73o5ui 120 4 Mechanistic Mechanistic NNP work_wgf2msbacfaetpobn6pl73o5ui 120 5 Characterization Characterization NNP work_wgf2msbacfaetpobn6pl73o5ui 120 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 120 7 the the DT work_wgf2msbacfaetpobn6pl73o5ui 120 8 Thioredoxin Thioredoxin NNP work_wgf2msbacfaetpobn6pl73o5ui 120 9 System System NNP work_wgf2msbacfaetpobn6pl73o5ui 120 10 in in IN work_wgf2msbacfaetpobn6pl73o5ui 120 11 the the DT work_wgf2msbacfaetpobn6pl73o5ui 120 12 Removal Removal NNP work_wgf2msbacfaetpobn6pl73o5ui 120 13 of of IN work_wgf2msbacfaetpobn6pl73o5ui 120 14 Hydrogen Hydrogen NNP work_wgf2msbacfaetpobn6pl73o5ui 120 15 Peroxide Peroxide NNP work_wgf2msbacfaetpobn6pl73o5ui 120 16 Venkat Venkat NNP work_wgf2msbacfaetpobn6pl73o5ui 120 17 R. R. NNP work_wgf2msbacfaetpobn6pl73o5ui 120 18 Pannala Pannala NNP work_wgf2msbacfaetpobn6pl73o5ui 120 19 , , , work_wgf2msbacfaetpobn6pl73o5ui 120 20 Ranjan Ranjan NNP work_wgf2msbacfaetpobn6pl73o5ui 120 21 K. K. NNP work_wgf2msbacfaetpobn6pl73o5ui 120 22 Dash Dash NNP work_wgf2msbacfaetpobn6pl73o5ui 120 23 . . . work_wgf2msbacfaetpobn6pl73o5ui 121 1 Bioengineering bioengineering NN work_wgf2msbacfaetpobn6pl73o5ui 121 2 and and CC work_wgf2msbacfaetpobn6pl73o5ui 121 3 Biotechnology Biotechnology NNP work_wgf2msbacfaetpobn6pl73o5ui 121 4 , , , work_wgf2msbacfaetpobn6pl73o5ui 121 5 Department Department NNP work_wgf2msbacfaetpobn6pl73o5ui 121 6 of of IN work_wgf2msbacfaetpobn6pl73o5ui 121 7 Physiology Physiology NNP work_wgf2msbacfaetpobn6pl73o5ui 121 8 , , , work_wgf2msbacfaetpobn6pl73o5ui 121 9 Medical Medical NNP work_wgf2msbacfaetpobn6pl73o5ui 121 10 College College NNP work_wgf2msbacfaetpobn6pl73o5ui 121 11 of of IN work_wgf2msbacfaetpobn6pl73o5ui 121 12 Wisconsin Wisconsin NNP work_wgf2msbacfaetpobn6pl73o5ui 121 13 , , , work_wgf2msbacfaetpobn6pl73o5ui 121 14 Wauwatosa Wauwatosa NNP work_wgf2msbacfaetpobn6pl73o5ui 121 15 , , , work_wgf2msbacfaetpobn6pl73o5ui 121 16 WI WI NNP work_wgf2msbacfaetpobn6pl73o5ui 121 17 , , , work_wgf2msbacfaetpobn6pl73o5ui 121 18 USA USA NNP work_wgf2msbacfaetpobn6pl73o5ui 121 19 . . . work_wgf2msbacfaetpobn6pl73o5ui 122 1 The the DT work_wgf2msbacfaetpobn6pl73o5ui 122 2 thioredoxin thioredoxin NN work_wgf2msbacfaetpobn6pl73o5ui 122 3 system system NN work_wgf2msbacfaetpobn6pl73o5ui 122 4 plays play VBZ work_wgf2msbacfaetpobn6pl73o5ui 122 5 a a DT work_wgf2msbacfaetpobn6pl73o5ui 122 6 critical critical JJ work_wgf2msbacfaetpobn6pl73o5ui 122 7 role role NN work_wgf2msbacfaetpobn6pl73o5ui 122 8 in in IN work_wgf2msbacfaetpobn6pl73o5ui 122 9 the the DT work_wgf2msbacfaetpobn6pl73o5ui 122 10 defense defense NN work_wgf2msbacfaetpobn6pl73o5ui 122 11 against against IN work_wgf2msbacfaetpobn6pl73o5ui 122 12 oxidative oxidative JJ work_wgf2msbacfaetpobn6pl73o5ui 122 13 stress stress NN work_wgf2msbacfaetpobn6pl73o5ui 122 14 by by IN work_wgf2msbacfaetpobn6pl73o5ui 122 15 removing remove VBG work_wgf2msbacfaetpobn6pl73o5ui 122 16 harmful harmful JJ work_wgf2msbacfaetpobn6pl73o5ui 122 17 hydrogen hydrogen NN work_wgf2msbacfaetpobn6pl73o5ui 122 18 peroxide peroxide NN work_wgf2msbacfaetpobn6pl73o5ui 122 19 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 122 20 H2O2 H2O2 NNP work_wgf2msbacfaetpobn6pl73o5ui 122 21 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 122 22 . . . work_wgf2msbacfaetpobn6pl73o5ui 123 1 Specifically specifically RB work_wgf2msbacfaetpobn6pl73o5ui 123 2 , , , work_wgf2msbacfaetpobn6pl73o5ui 123 3 MAC MAC NNP work_wgf2msbacfaetpobn6pl73o5ui 123 4 Inhibitors inhibitor NNS work_wgf2msbacfaetpobn6pl73o5ui 123 5 Neutralize neutralize VBP work_wgf2msbacfaetpobn6pl73o5ui 123 6 the the DT work_wgf2msbacfaetpobn6pl73o5ui 123 7 Pro pro JJ work_wgf2msbacfaetpobn6pl73o5ui 123 8 - - JJ work_wgf2msbacfaetpobn6pl73o5ui 123 9 Apoptotic apoptotic JJ work_wgf2msbacfaetpobn6pl73o5ui 123 10 Effects Effects NNPS work_wgf2msbacfaetpobn6pl73o5ui 123 11 of of IN work_wgf2msbacfaetpobn6pl73o5ui 123 12 Tbid Tbid NNP work_wgf2msbacfaetpobn6pl73o5ui 123 13 Tyrosine Tyrosine NNP work_wgf2msbacfaetpobn6pl73o5ui 123 14 Phosphorylation Phosphorylation NNP work_wgf2msbacfaetpobn6pl73o5ui 123 15 of of IN work_wgf2msbacfaetpobn6pl73o5ui 123 16 Mitochondrial mitochondrial NN work_wgf2msbacfaetpobn6pl73o5ui 123 17 Ca2 ca2 NN work_wgf2msbacfaetpobn6pl73o5ui 123 18 + + DT work_wgf2msbacfaetpobn6pl73o5ui 123 19 Uniporter Uniporter NNP work_wgf2msbacfaetpobn6pl73o5ui 123 20 Regulates Regulates NNP work_wgf2msbacfaetpobn6pl73o5ui 123 21 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 123 22 Ca2 ca2 NN work_wgf2msbacfaetpobn6pl73o5ui 123 23 + + CC work_wgf2msbacfaetpobn6pl73o5ui 123 24 Uptake Uptake NNP work_wgf2msbacfaetpobn6pl73o5ui 123 25 Cardioprotective Cardioprotective NNP work_wgf2msbacfaetpobn6pl73o5ui 123 26 Roles Roles NNPS work_wgf2msbacfaetpobn6pl73o5ui 123 27 of of IN work_wgf2msbacfaetpobn6pl73o5ui 123 28 Neuronal Neuronal NNP work_wgf2msbacfaetpobn6pl73o5ui 123 29 Ca2 ca2 NN work_wgf2msbacfaetpobn6pl73o5ui 123 30 + + CC work_wgf2msbacfaetpobn6pl73o5ui 123 31 Sensor-1 Sensor-1 NNP work_wgf2msbacfaetpobn6pl73o5ui 123 32 during during IN work_wgf2msbacfaetpobn6pl73o5ui 123 33 Stress Stress NNP work_wgf2msbacfaetpobn6pl73o5ui 123 34 Initiation Initiation NNP work_wgf2msbacfaetpobn6pl73o5ui 123 35 of of IN work_wgf2msbacfaetpobn6pl73o5ui 123 36 Electron Electron NNP work_wgf2msbacfaetpobn6pl73o5ui 123 37 Transport Transport NNP work_wgf2msbacfaetpobn6pl73o5ui 123 38 Activity Activity NNP work_wgf2msbacfaetpobn6pl73o5ui 123 39 and and CC work_wgf2msbacfaetpobn6pl73o5ui 123 40 a a DT work_wgf2msbacfaetpobn6pl73o5ui 123 41 Decrease Decrease NNP work_wgf2msbacfaetpobn6pl73o5ui 123 42 of of IN work_wgf2msbacfaetpobn6pl73o5ui 123 43 Oxidative Oxidative NNP work_wgf2msbacfaetpobn6pl73o5ui 123 44 Stress Stress NNP work_wgf2msbacfaetpobn6pl73o5ui 123 45 Occur occur VB work_wgf2msbacfaetpobn6pl73o5ui 123 46 Simultaneously simultaneously RB work_wgf2msbacfaetpobn6pl73o5ui 123 47 during during IN work_wgf2msbacfaetpobn6pl73o5ui 123 48 Embryonic Embryonic NNP work_wgf2msbacfaetpobn6pl73o5ui 123 49 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 123 50 De De NNP work_wgf2msbacfaetpobn6pl73o5ui 123 51 ... ... . work_wgf2msbacfaetpobn6pl73o5ui 124 1 The the DT work_wgf2msbacfaetpobn6pl73o5ui 124 2 Stoichiometry Stoichiometry NNP work_wgf2msbacfaetpobn6pl73o5ui 124 3 between between IN work_wgf2msbacfaetpobn6pl73o5ui 124 4 MICU1 micu1 NN work_wgf2msbacfaetpobn6pl73o5ui 124 5 and and CC work_wgf2msbacfaetpobn6pl73o5ui 124 6 MCU MCU NNP work_wgf2msbacfaetpobn6pl73o5ui 124 7 Determines determine VBZ work_wgf2msbacfaetpobn6pl73o5ui 124 8 the the DT work_wgf2msbacfaetpobn6pl73o5ui 124 9 Different Different NNP work_wgf2msbacfaetpobn6pl73o5ui 124 10 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 124 11 Ca2 ca2 NN work_wgf2msbacfaetpobn6pl73o5ui 124 12 + + NFP work_wgf2msbacfaetpobn6pl73o5ui 124 13 Uptake Uptake NNP work_wgf2msbacfaetpobn6pl73o5ui 124 14 Phenotypes Phenotypes NNPS work_wgf2msbacfaetpobn6pl73o5ui 124 15 in in IN work_wgf2msbacfaetpobn6pl73o5ui 124 16 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 124 17 and and CC work_wgf2msbacfaetpobn6pl73o5ui 124 18 Liver Liver NNP work_wgf2msbacfaetpobn6pl73o5ui 124 19 ER ER NNP work_wgf2msbacfaetpobn6pl73o5ui 124 20 Calcium Calcium NNP work_wgf2msbacfaetpobn6pl73o5ui 124 21 Release Release NNP work_wgf2msbacfaetpobn6pl73o5ui 124 22 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 124 23 Tuned tune VBN work_wgf2msbacfaetpobn6pl73o5ui 124 24 by by IN work_wgf2msbacfaetpobn6pl73o5ui 124 25 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 124 26 Redox Redox NNP work_wgf2msbacfaetpobn6pl73o5ui 124 27 Nanodomains Nanodomains NNP work_wgf2msbacfaetpobn6pl73o5ui 124 28 Reactive Reactive NNP work_wgf2msbacfaetpobn6pl73o5ui 124 29 Oxygen Oxygen NNP work_wgf2msbacfaetpobn6pl73o5ui 124 30 Species Species NNPS work_wgf2msbacfaetpobn6pl73o5ui 124 31 ( ( -LRB- work_wgf2msbacfaetpobn6pl73o5ui 124 32 ROS ROS NNP work_wgf2msbacfaetpobn6pl73o5ui 124 33 ) ) -RRB- work_wgf2msbacfaetpobn6pl73o5ui 124 34 Suppress Suppress NNP work_wgf2msbacfaetpobn6pl73o5ui 124 35 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 124 36 Motility Motility NNP work_wgf2msbacfaetpobn6pl73o5ui 124 37 Miro1 miro1 CD work_wgf2msbacfaetpobn6pl73o5ui 124 38 is be VBZ work_wgf2msbacfaetpobn6pl73o5ui 124 39 Dispensable dispensable JJ work_wgf2msbacfaetpobn6pl73o5ui 124 40 for for IN work_wgf2msbacfaetpobn6pl73o5ui 124 41 Calcium Calcium NNP work_wgf2msbacfaetpobn6pl73o5ui 124 42 - - HYPH work_wgf2msbacfaetpobn6pl73o5ui 124 43 Mediated mediate VBN work_wgf2msbacfaetpobn6pl73o5ui 124 44 Inhibition Inhibition NNP work_wgf2msbacfaetpobn6pl73o5ui 124 45 of of IN work_wgf2msbacfaetpobn6pl73o5ui 124 46 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 124 47 Movement Movement NNP work_wgf2msbacfaetpobn6pl73o5ui 124 48 Mitochondrial Mitochondrial NNP work_wgf2msbacfaetpobn6pl73o5ui 124 49 Fusion Fusion NNP work_wgf2msbacfaetpobn6pl73o5ui 124 50 Dynamics Dynamics NNPS work_wgf2msbacfaetpobn6pl73o5ui 124 51 in in IN work_wgf2msbacfaetpobn6pl73o5ui 124 52 the the DT work_wgf2msbacfaetpobn6pl73o5ui 124 53 Heart Heart NNP work_wgf2msbacfaetpobn6pl73o5ui 124 54 Mechanistic Mechanistic NNP work_wgf2msbacfaetpobn6pl73o5ui 124 55 Characterization Characterization NNP work_wgf2msbacfaetpobn6pl73o5ui 124 56 of of IN work_wgf2msbacfaetpobn6pl73o5ui 124 57 the the DT work_wgf2msbacfaetpobn6pl73o5ui 124 58 Thioredoxin Thioredoxin NNP work_wgf2msbacfaetpobn6pl73o5ui 124 59 System System NNP work_wgf2msbacfaetpobn6pl73o5ui 124 60 in in IN work_wgf2msbacfaetpobn6pl73o5ui 124 61 the the DT work_wgf2msbacfaetpobn6pl73o5ui 124 62 Removal Removal NNP work_wgf2msbacfaetpobn6pl73o5ui 124 63 of of IN work_wgf2msbacfaetpobn6pl73o5ui 124 64 Hydrogen Hydrogen NNP work_wgf2msbacfaetpobn6pl73o5ui 124 65 Peroxide Peroxide NNP