Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment. | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.3791/52886 Corpus ID: 207550788Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment. @article{Walker2015EstablishmentOA, title={Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment.}, author={Janice L. Walker and B. Bleaken and I. Wolff and A. S. Menko}, journal={Journal of visualized experiments : JoVE}, year={2015}, volume={100}, pages={ e52886 } } Janice L. Walker, B. Bleaken, +1 author A. S. Menko Published 2015 Biology, Medicine Journal of visualized experiments : JoVE The major impediment to understanding how an epithelial tissue executes wound repair is the limited availability of models in which it is possible to follow and manipulate the wound response ex vivo in an environment that closely mimics that of epithelial tissue injury in vivo. This issue was addressed by creating a clinically relevant epithelial ex vivo injury-repair model based on cataract surgery. In this culture model, the response of the lens epithelium to wounding can be followed live in… Expand View on PubMed europepmc.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 5 CitationsBackground Citations 2 Methods Citations 2 View All Figures and Topics from this paper figure 1 figure 2 Cataract double-strand break repair via homologous recombination Epithelium Structure of lens capsule Soft Tissue Injuries Posterior Capsule of the Lens Providing (action) Leukemia, B-Cell Lens Diseases 5 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Fibrosis: Shared Lessons From the Lens and Cornea A. S. Menko, Janice L. Walker, M. A. Stepp Medicine Anatomical record 2019 5 View 20 excerpts, cites background Save Alert Research Feed In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype J. Walker, B. Bleaken, A. Romisher, A. A. Alnwibit, A. S. Menko Biology, Medicine Molecular biology of the cell 2018 17 PDF View 3 excerpts, cites methods Save Alert Research Feed Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens A. Sue Menko, JodiRae DeDreu, Caitlin M. Logan, Heather Paulson, A. Levin, Janice L. Walker Medicine FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Save Alert Research Feed Development of a novel ex vivo equine corneal model T. Marlo, E. Giuliano, A. Sharma, R. Mohan Medicine Veterinary ophthalmology 2017 2 Save Alert Research Feed Cells activated for wound repair have the potential to direct collective invasion of an epithelium B. Bleaken, A. S. Menko, Janice L. Walker Biology, Medicine Molecular biology of the cell 2016 11 PDF View 3 excerpts, cites methods and background Save Alert Research Feed References SHOWING 1-10 OF 46 REFERENCES SORT BYRelevance Most Influenced Papers Recency Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. B. M. Stramer, J. Zieske, Jae-Chang Jung, J. Austin, M. Fini Biology, Medicine Investigative ophthalmology & visual science 2003 185 PDF Save Alert Research Feed An in vivo model of wound healing in genetically modified skin-humanized mice. M. Escámez, M. García, +4 authors M. del Río Medicine, Biology The Journal of investigative dermatology 2004 106 PDF Save Alert Research Feed Disruption of the basement membrane after corneal débridement. D. D. Sta Iglesia, M. A. Stepp Biology, Medicine Investigative ophthalmology & visual science 2000 47 PDF Save Alert Research Feed Removal of the basement membrane enhances corneal wound healing. S. 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Cooper, W. Wood, B. Stramer, P. Martin Biology, Medicine Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004 242 Save Alert Research Feed Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. M. Ferguson, S. O'kane Medicine, Biology Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004 682 PDF Save Alert Research Feed ... 1 2 3 4 5 ... Related Papers Abstract Figures and Topics 5 Citations 46 References Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. 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