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PublisherName : BioMed Central

PublisherLocation : London

PublisherImprintName : BioMed Central

BAG-1 can predict survival from breast cancer
ArticleInfo

ArticleID : 4003

ArticleDOI : 10.1186/gb-spotlight-20010308-01

ArticleCitationID : spotlight-20010308-01

ArticleSequenceNumber : 74

ArticleCategory : Research news

ArticleFirstPage : 1

ArticleLastPage : 2

ArticleHistory :
RegistrationDate : 2001–03–08

OnlineDate : 2001–03–08

ArticleCopyright : BioMed Central Ltd2001

ArticleGrants :

ArticleContext : 130592211



Tudor Toma
Email: ttoma@mail.dntis.ro

Measuring tumour levels of the protein BAG-1 can predict which women with localised breast cancer
are at greatest risk of metastases, according to a paper in the February Journal of Clinical Oncology.
Bruce Turner, from Thomas Jefferson Universityin Philadelphia, and colleagues studied 122 women
with early stage breast cancer. They analysed paraffin blocks of excised tumors and found that cytosolic
immunostaining for BAG-1 - a protein that inhibits apoptosis - was greater in 79 of 122 invasive breast
cancers.

Interestingly, 82% of women who had tumours that contained high levels of BAG-1 had a longer
survival time and were still alive 10 years after diagnosis, compared with 42% of women whose tumours
contained low levels of the protein. No other biomarkers tested reached statistical significance for
predicting survival (J Clin Oncol 2001, 19:992-1000).

Patients with tumours containing low levels of BAG-1 may benefit from more aggressive cancer
treatments early in the course of the disease.

References
1. Turner BC, Krajewski S, Krajewska M, et al:BAG-1: A novel biomarker predicting long-term
survival in early-stage breast cancer. J Clin Oncol 2001, 19:992-1000., [http://www.jco.org/cgi/content/
abstract/19/4/992]

2. Thomas Jefferson University, [http://www.tju.edu/]

This PDF file was created after publication.

http://www.jco.org/cgi/content/abstract/19/4/992
http://www.jco.org/cgi/content/abstract/19/4/992
http://www.tju.edu/

	BAG-1 can predict survival from breast cancer
	References