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bax in neuroendocrine lung tumors. Am J Pathol 1996;149:
1949 –52.

67. Umpiere SA, Burke TW, Tornos C, Ordonez N, Levenback C,
Morris M. Immunohistochemical analysis of uterine papil-
lary serous carcinomas for estrogen and progesterone recep-
tors. Int J Gynecol Pathol 1994;13:127–30.

68. Nanbu K, Konishi J, Komatsu T, Mandai M, Yamamoto S,
Kurada H, et al. Expression of heat shock proteins HSP70
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Book Review

Fenoglio-Preiser CM, Noffsinger AE, Stemmer-
mann GN, Lantz PE, Listrom MB, Rilke FO:
Gastrointestinal Pathology Plus on CD-
ROM, Philadelphia, Lippincott Williams &
Wilkins, 1999 ($350).

The second edition of Gastrointestinal Pathology
is now available on CD-ROM. The electronic ver-
sion contains an expanded text and more illus-
trations. It runs under Windows or Macintosh
operating systems and requires at least 8 MB of
RAM. I have run it on Windows 95, 98, and NT.
Installation notes recommend setting virtual
memory at 20 MB or greater for optimal pictorial
quality. A good rule of thumb is to set virtual
memory at twice the amount of RAM, but keep in
mind that Windows prefers to self-manage vir-
tual memory for most applications. The produc-
tion disk contains 270 MB of data, with approx-
imately 85% of the space devoted to pictures and
diagrams. A combination of software products
are bundled together to run this reference work.
The vendors include Folio Corporation for text
retrieval and Iterated Systems for image display.

Navigation around the disk is easy at the top
level but awkward when paging through individ-
ual chapters. There are shortcuts to individual
topics via the Go To option, but one needs to
enter a numerical address. Hyperlinks to pictures
and illustrations allow you to overlay windows
for side-by-side comparisons with the written
text, and there is a clever pop-up option to view
immediately any cited reference. An effective
search engine that uses Boolean logic is available
for names or key words, and there are shortcuts
to jump to your results. Instructions on printing

text items and exporting images are available in
the Read Me files. Overall, this disk contains
sufficient tools to keep most users occupied for a
long time.

The text and illustrations have been revised
for the second edition, and references are up-
dated through 1995 (some through 1996). A se-
lective review of dysplasia in ulcerative colitis
shows it to be clear, concise, and complete. The
recommendations for dysplasia-associated le-
sions or masses are practical. The section on
gastritis generally follows the Sydney System
with the usual caveats. However, I was disap-
pointed not to find the 1996 article by Dixon et
al. concerning the updated principles and grad-
ing data. A discussion of gastroesophageal reflux
disease, 24-h acid testing, and short-segment
Barrett esophagus is lacking. Gross photographs,
radiographs, and diagrams are of excellent qual-
ity. Unfortunately, photomicrographs appear
pixelated and rapidly degraded when zoomed.

The combination of content, search capabil-
ities, and the ability to print text and export
images makes this CD a powerful reference work.
The one disadvantage of this format is the quality
of the photomicrographs. Keeping in mind that
the capacity of an ordinary 75-cent disk is 650
MB and the availability of file compression tech-
nology, one would think that medical publishers
could produce higher quality microscopic im-
ages.

Peter A. McCue
Thomas Jefferson University
Philadelphia, Pennsylvania

388 Modern Pathology


	Book Review