id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
5d86nz82z8n	Mark Evan Fraser	Novel Anti-Viral Strategies for Lipid-Enveloped Viruses	2019		.txt	text/plain	768	22	34	By utilizing UCN-01 at lower concentrations than used for anti-cancer clinical trials it is hypothesized that viral replication in multiple lipid enveloped viruses can be inhibited in two ways: first, by inhibiting matrix protein localization to the plasma membrane and viral budding by localizing PS to endomembranes from the plasma membrane, and second, by inhibiting viral infection which utilizes apoptotic mimicry by reducing available PS on viral particles and by also inhibiting host cell kinase activity of receptor proteins known to interact with PS. Using these concentrations UCN-01 was shown to reduce plasma membrane localization of Ebola VP40, Marburg VP40, and HIV-1-Gag significantly using confocal imaging of recombinant GFP tagged viral proteins.	cache/5d86nz82z8n.txt	txt/5d86nz82z8n.txt