id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
7m01bk15f0h	Himani N. Patel	Computational Studies on HMG-CoA Reductases and Other Biomolecular Systems	2023		.txt	text/plain	439	18	38	The computational studies performed using theozyme (DFT) and QM/MM models show that the thiohemiacetal decomposition reaction, that occurs between the two hydride transfer reactions, has an energy barrier of ~ 7 kcal/mol in presence of cofactor NADH. This suggests soaking the PmHMGR crystals in photocaged substrate and cofactor since the flap domain only closes over the active site in presence of both ligands.	cache/7m01bk15f0h.txt	txt/7m01bk15f0h.txt