id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
sj139022736	Matthew David Lynx	An Investigation into 3'-Azido-3'-Deoxythymidine Toxicity: Inhibtion of Thymidine Phosphorylation	2008		.txt	text/plain	324	16	50	From this work, an alternative mechanism for AZT toxicity was proposed, wherein AZT's inhibition of thymidine phosphorylation leads to a depletion of the TTP pool, which causes mitochondrial DNA depletion. The toxicity of AZT is hypothesized to be due to AZT-5'-triphosphate (AZT-TP) inhibition of the mitochondrial DNA polymerase γ, leading to mitochondrial DNA depletion.	cache/sj139022736.txt	txt/sj139022736.txt