Expressive writing has been established over the last several decades as an effective way to cope with distressing life events. Although the literature has clearly established the health benefits of expressive writing, the mechanisms that cause those benefits are still under debate. An area that has yet to be explored in the expressive writing literature is that of blame attributions in the writing. Previous research has shown that placing blame on oneself or others is associated with poorer physical and mental health outcomes. However, no studies have tested the effects of manipulating blame in the writing. The current study filled a gap in both the expressive writing and blame literatures by manipulating self versus other blame in the writing of participants. Approximately 217 undergraduates were randomly assigned to engage in one of five 25-min writing tasks. The first group wrote about a distressing event and served as a standard expressive writing control. A second control group wrote about trivial events. The remaining 3 groups were asked to write about a distressing event while engaging in one of the following: (a) placing the blame for the event on oneself, (b) placing the blame for the event on someone else, or (c) not blaming anyone for the event. All groups completed pre- and post-test measures of psychological and physical symptomatology. Results found that participants in the other-blame group showed significantly less symptom reduction that those in the standard expressive writing group. However, participants in the self-blame group showed symptom reduction equivalent to that of the standard expressive writing group. The findings point to the study of self-blame, particularly behavioral self-blame, as a promising future research direction in the expressive writing literature.