id sid tid token lemma pos 02870v8507t 1 1 in in ADP 02870v8507t 1 2 many many ADJ 02870v8507t 1 3 species specie NOUN 02870v8507t 1 4 , , PUNCT 02870v8507t 1 5 the the DET 02870v8507t 1 6 process process NOUN 02870v8507t 1 7 of of ADP 02870v8507t 1 8 ovarian ovarian ADJ 02870v8507t 1 9 follicle follicle NOUN 02870v8507t 1 10 selection selection NOUN 02870v8507t 1 11 is be AUX 02870v8507t 1 12 the the DET 02870v8507t 1 13 rate rate NOUN 02870v8507t 1 14 - - PUNCT 02870v8507t 1 15 limiting limit VERB 02870v8507t 1 16 step step NOUN 02870v8507t 1 17 by by ADP 02870v8507t 1 18 which which PRON 02870v8507t 1 19 a a DET 02870v8507t 1 20 species species NOUN 02870v8507t 1 21 - - PUNCT 02870v8507t 1 22 specific specific ADJ 02870v8507t 1 23 number number NOUN 02870v8507t 1 24 of of ADP 02870v8507t 1 25 follicles follicle NOUN 02870v8507t 1 26 are be AUX 02870v8507t 1 27 designated designate VERB 02870v8507t 1 28 to to PART 02870v8507t 1 29 form form VERB 02870v8507t 1 30 mature mature ADJ 02870v8507t 1 31 oocytes oocyte NOUN 02870v8507t 1 32 in in ADP 02870v8507t 1 33 the the DET 02870v8507t 1 34 reproductively reproductively ADV 02870v8507t 1 35 active active ADJ 02870v8507t 1 36 female female NOUN 02870v8507t 1 37 . . PUNCT 02870v8507t 2 1 selected select VERB 02870v8507t 2 2 follicles follicle NOUN 02870v8507t 2 3 then then ADV 02870v8507t 2 4 transition transition VERB 02870v8507t 2 5 from from ADP 02870v8507t 2 6 an an DET 02870v8507t 2 7 undifferentiated undifferentiated ADJ 02870v8507t 2 8 to to ADP 02870v8507t 2 9 a a DET 02870v8507t 2 10 differentiated differentiated ADJ 02870v8507t 2 11 state state NOUN 02870v8507t 2 12 . . PUNCT 02870v8507t 3 1 this this DET 02870v8507t 3 2 thesis thesis NOUN 02870v8507t 3 3 addresses address VERB 02870v8507t 3 4 the the DET 02870v8507t 3 5 hypothesis hypothesis NOUN 02870v8507t 3 6 that that PRON 02870v8507t 3 7 coordinately coordinately ADV 02870v8507t 3 8 timed time VERB 02870v8507t 3 9 cell cell NOUN 02870v8507t 3 10 - - PUNCT 02870v8507t 3 11 signaling signal VERB 02870v8507t 3 12 events event NOUN 02870v8507t 3 13 are be AUX 02870v8507t 3 14 requisite requisite ADJ 02870v8507t 3 15 for for ADP 02870v8507t 3 16 the the DET 02870v8507t 3 17 onset onset NOUN 02870v8507t 3 18 of of ADP 02870v8507t 3 19 differentiation differentiation NOUN 02870v8507t 3 20 , , PUNCT 02870v8507t 3 21 resulting result VERB 02870v8507t 3 22 from from ADP 02870v8507t 3 23 a a DET 02870v8507t 3 24 release release NOUN 02870v8507t 3 25 from from ADP 02870v8507t 3 26 inhibitory inhibitory ADJ 02870v8507t 3 27 signaling signal VERB 02870v8507t 3 28 in in ADP 02870v8507t 3 29 combination combination NOUN 02870v8507t 3 30 with with ADP 02870v8507t 3 31 stimulatory stimulatory ADJ 02870v8507t 3 32 cell cell NOUN 02870v8507t 3 33 signaling signal VERB 02870v8507t 3 34 events event NOUN 02870v8507t 3 35 . . PUNCT 02870v8507t 4 1 the the DET 02870v8507t 4 2 hen hen NOUN 02870v8507t 4 3 provides provide VERB 02870v8507t 4 4 an an DET 02870v8507t 4 5 excellent excellent ADJ 02870v8507t 4 6 model model NOUN 02870v8507t 4 7 to to PART 02870v8507t 4 8 study study VERB 02870v8507t 4 9 granulosa granulosa ADJ 02870v8507t 4 10 cell cell NOUN 02870v8507t 4 11 differentiation differentiation NOUN 02870v8507t 4 12 based base VERB 02870v8507t 4 13 on on ADP 02870v8507t 4 14 large large ADJ 02870v8507t 4 15 follicle follicle NOUN 02870v8507t 4 16 size size NOUN 02870v8507t 4 17 and and CCONJ 02870v8507t 4 18 easy easy ADJ 02870v8507t 4 19 access access NOUN 02870v8507t 4 20 to to ADP 02870v8507t 4 21 pure pure ADJ 02870v8507t 4 22 populations population NOUN 02870v8507t 4 23 of of ADP 02870v8507t 4 24 granulosa granulosa ADJ 02870v8507t 4 25 cells cell NOUN 02870v8507t 4 26 from from ADP 02870v8507t 4 27 all all DET 02870v8507t 4 28 stages stage NOUN 02870v8507t 4 29 of of ADP 02870v8507t 4 30 follicle follicle NOUN 02870v8507t 4 31 development development NOUN 02870v8507t 4 32 . . PUNCT 02870v8507t 5 1 treatment treatment NOUN 02870v8507t 5 2 of of ADP 02870v8507t 5 3 undifferentiated undifferentiated ADJ 02870v8507t 5 4 granulosa granulosa ADJ 02870v8507t 5 5 cells cell NOUN 02870v8507t 5 6 with with ADP 02870v8507t 5 7 transforming transform VERB 02870v8507t 5 8 growth growth NOUN 02870v8507t 5 9 factor factor NOUN 02870v8507t 5 10 ( ( PUNCT 02870v8507t 5 11 tgf)β1 tgf)β1 NUM 02870v8507t 5 12 increased increase VERB 02870v8507t 5 13 fshr fshr ADJ 02870v8507t 5 14 mrna mrna NOUN 02870v8507t 5 15 and and CCONJ 02870v8507t 5 16 enhanced enhance VERB 02870v8507t 5 17 fsh fsh NOUN 02870v8507t 5 18 - - PUNCT 02870v8507t 5 19 induced induce VERB 02870v8507t 5 20 progesterone progesterone NOUN 02870v8507t 5 21 production production NOUN 02870v8507t 5 22 . . PUNCT 02870v8507t 6 1 dissimilar dissimilar ADJ 02870v8507t 6 2 results result NOUN 02870v8507t 6 3 were be AUX 02870v8507t 6 4 obtained obtain VERB 02870v8507t 6 5 with with ADP 02870v8507t 6 6 the the DET 02870v8507t 6 7 related relate VERB 02870v8507t 6 8 protein protein NOUN 02870v8507t 6 9 , , PUNCT 02870v8507t 6 10 activin activin NOUN 02870v8507t 6 11 , , PUNCT 02870v8507t 6 12 as as SCONJ 02870v8507t 6 13 high high ADJ 02870v8507t 6 14 levels level NOUN 02870v8507t 6 15 of of ADP 02870v8507t 6 16 the the DET 02870v8507t 6 17 endogenous endogenous ADJ 02870v8507t 6 18 activin activin NOUN 02870v8507t 6 19 binding bind VERB 02870v8507t 6 20 protein protein NOUN 02870v8507t 6 21 , , PUNCT 02870v8507t 6 22 follistatin follistatin NOUN 02870v8507t 6 23 , , PUNCT 02870v8507t 6 24 precluded precluded ADJ 02870v8507t 6 25 activin activin NOUN 02870v8507t 6 26 - - PUNCT 02870v8507t 6 27 mediated mediate VERB 02870v8507t 6 28 transcription transcription NOUN 02870v8507t 6 29 . . PUNCT 02870v8507t 7 1 the the DET 02870v8507t 7 2 differentiation differentiation NOUN 02870v8507t 7 3 - - PUNCT 02870v8507t 7 4 inducing induce VERB 02870v8507t 7 5 effects effect NOUN 02870v8507t 7 6 of of ADP 02870v8507t 7 7 tgfβ1 tgfβ1 NOUN 02870v8507t 7 8 were be AUX 02870v8507t 7 9 attenuated attenuate VERB 02870v8507t 7 10 by by ADP 02870v8507t 7 11 activation activation NOUN 02870v8507t 7 12 of of ADP 02870v8507t 7 13 erk erk PROPN 02870v8507t 7 14 signaling signaling PROPN 02870v8507t 7 15 . . PUNCT 02870v8507t 8 1 while while SCONJ 02870v8507t 8 2 erk erk PROPN 02870v8507t 8 3 signaling signal VERB 02870v8507t 8 4 inhibited inhibited ADJ 02870v8507t 8 5 tgfβ1 tgfβ1 NOUN 02870v8507t 8 6 induced induce VERB 02870v8507t 8 7 differentiation differentiation NOUN 02870v8507t 8 8 , , PUNCT 02870v8507t 8 9 it it PRON 02870v8507t 8 10 up up ADV 02870v8507t 8 11 - - PUNCT 02870v8507t 8 12 regulated regulate VERB 02870v8507t 8 13 tgfβ1 tgfβ1 NOUN 02870v8507t 8 14 mrna mrna PROPN 02870v8507t 8 15 , , PUNCT 02870v8507t 9 1 indicating indicate VERB 02870v8507t 9 2 that that SCONJ 02870v8507t 9 3 alleviation alleviation NOUN 02870v8507t 9 4 of of ADP 02870v8507t 9 5 erk erk PROPN 02870v8507t 9 6 signaling signaling PROPN 02870v8507t 9 7 is be AUX 02870v8507t 9 8 requisite requisite ADJ 02870v8507t 9 9 for for ADP 02870v8507t 9 10 tgfβ1 tgfβ1 NOUN 02870v8507t 9 11 induced induce VERB 02870v8507t 9 12 differentiation differentiation NOUN 02870v8507t 9 13 . . PUNCT 02870v8507t 10 1 results result NOUN 02870v8507t 10 2 also also ADV 02870v8507t 10 3 indicate indicate VERB 02870v8507t 10 4 that that SCONJ 02870v8507t 10 5 erk erk NOUN 02870v8507t 10 6 up up ADV 02870v8507t 10 7 - - PUNCT 02870v8507t 10 8 regulates regulate NOUN 02870v8507t 10 9 mapk mapk NOUN 02870v8507t 10 10 phosphatases phosphatase NOUN 02870v8507t 10 11 ( ( PUNCT 02870v8507t 10 12 mkps mkps PROPN 02870v8507t 10 13 ) ) PUNCT 02870v8507t 10 14 mkp-1 mkp-1 X 02870v8507t 10 15 and and CCONJ 02870v8507t 10 16 -3 -3 X 02870v8507t 10 17 , , PUNCT 02870v8507t 10 18 as as ADV 02870v8507t 10 19 well well ADV 02870v8507t 10 20 as as ADP 02870v8507t 10 21 dual dual ADJ 02870v8507t 10 22 specificity specificity NOUN 02870v8507t 10 23 phosphatase phosphatase NOUN 02870v8507t 10 24 ( ( PUNCT 02870v8507t 10 25 dusp)-5 dusp)-5 NOUN 02870v8507t 10 26 . . PUNCT 02870v8507t 11 1 in in ADP 02870v8507t 11 2 turn turn NOUN 02870v8507t 11 3 , , PUNCT 02870v8507t 11 4 erk erk PROPN 02870v8507t 11 5 signaling signaling NOUN 02870v8507t 11 6 is be AUX 02870v8507t 11 7 terminated terminate VERB 02870v8507t 11 8 , , PUNCT 02870v8507t 11 9 allowing allow VERB 02870v8507t 11 10 tgfβ1 tgfβ1 NOUN 02870v8507t 11 11 to to PART 02870v8507t 11 12 initiate initiate VERB 02870v8507t 11 13 differentiation differentiation NOUN 02870v8507t 11 14 . . PUNCT 02870v8507t 12 1 while while SCONJ 02870v8507t 12 2 erk erk PROPN 02870v8507t 12 3 signaling signaling NOUN 02870v8507t 12 4 inhibits inhibit NOUN 02870v8507t 12 5 differentiation differentiation NOUN 02870v8507t 12 6 in in ADP 02870v8507t 12 7 granulosa granulosa ADJ 02870v8507t 12 8 cells cell NOUN 02870v8507t 12 9 from from ADP 02870v8507t 12 10 undifferentiated undifferentiated ADJ 02870v8507t 12 11 follicles follicle NOUN 02870v8507t 12 12 , , PUNCT 02870v8507t 12 13 it it PRON 02870v8507t 12 14 becomes becomes AUX 02870v8507t 12 15 required require VERB 02870v8507t 12 16 for for ADP 02870v8507t 12 17 differentiation differentiation NOUN 02870v8507t 12 18 in in ADP 02870v8507t 12 19 preovulatory preovulatory ADJ 02870v8507t 12 20 follicles follicle NOUN 02870v8507t 12 21 . . PUNCT 02870v8507t 13 1 this this DET 02870v8507t 13 2 transition transition NOUN 02870v8507t 13 3 occurs occur VERB 02870v8507t 13 4 post post ADJ 02870v8507t 13 5 - - ADJ 02870v8507t 13 6 follicle follicle ADJ 02870v8507t 13 7 selection selection NOUN 02870v8507t 13 8 , , PUNCT 02870v8507t 13 9 as as ADP 02870v8507t 13 10 results result NOUN 02870v8507t 13 11 from from ADP 02870v8507t 13 12 the the DET 02870v8507t 13 13 9 9 NUM 02870v8507t 13 14 - - SYM 02870v8507t 13 15 12 12 NUM 02870v8507t 13 16 mm mm PROPN 02870v8507t 13 17 ( ( PUNCT 02870v8507t 13 18 most most ADV 02870v8507t 13 19 recently recently ADV 02870v8507t 13 20 selected select VERB 02870v8507t 13 21 ) ) PUNCT 02870v8507t 13 22 follicle follicle NOUN 02870v8507t 13 23 indicate indicate VERB 02870v8507t 13 24 that that SCONJ 02870v8507t 13 25 erk erk NOUN 02870v8507t 13 26 signaling signal VERB 02870v8507t 13 27 inhibits inhibit NOUN 02870v8507t 13 28 steroidogenesis steroidogenesis NOUN 02870v8507t 13 29 at at ADP 02870v8507t 13 30 this this DET 02870v8507t 13 31 stage stage NOUN 02870v8507t 13 32 . . PUNCT 02870v8507t 14 1 significantly significantly ADV 02870v8507t 14 2 , , PUNCT 02870v8507t 14 3 while while SCONJ 02870v8507t 14 4 previous previous ADJ 02870v8507t 14 5 work work NOUN 02870v8507t 14 6 has have AUX 02870v8507t 14 7 demonstrated demonstrate VERB 02870v8507t 14 8 that that SCONJ 02870v8507t 14 9 protein protein NOUN 02870v8507t 14 10 kinase kinase NOUN 02870v8507t 14 11 c c NOUN 02870v8507t 14 12 ( ( PUNCT 02870v8507t 14 13 pkc pkc NOUN 02870v8507t 14 14 ) ) PUNCT 02870v8507t 14 15 inhibits inhibit VERB 02870v8507t 14 16 differentiation differentiation NOUN 02870v8507t 14 17 in in ADP 02870v8507t 14 18 granulosa granulosa ADJ 02870v8507t 14 19 cells cell NOUN 02870v8507t 14 20 from from ADP 02870v8507t 14 21 prehierarchal prehierarchal ADJ 02870v8507t 14 22 follicles follicle NOUN 02870v8507t 14 23 , , PUNCT 02870v8507t 14 24 results result NOUN 02870v8507t 14 25 herein herein ADV 02870v8507t 14 26 demonstrate demonstrate VERB 02870v8507t 14 27 that that SCONJ 02870v8507t 14 28 pkc pkc ADJ 02870v8507t 14 29 activity activity NOUN 02870v8507t 14 30 is be AUX 02870v8507t 14 31 required require VERB 02870v8507t 14 32 for for ADP 02870v8507t 14 33 differentiation differentiation NOUN 02870v8507t 14 34 of of ADP 02870v8507t 14 35 granulosa granulosa ADJ 02870v8507t 14 36 cells cell NOUN 02870v8507t 14 37 in in ADP 02870v8507t 14 38 preovulatory preovulatory ADJ 02870v8507t 14 39 follicles follicle NOUN 02870v8507t 14 40 . . PUNCT 02870v8507t 15 1 unlike unlike ADP 02870v8507t 15 2 erk erk PROPN 02870v8507t 15 3 signaling signaling PROPN 02870v8507t 15 4 , , PUNCT 02870v8507t 15 5 the the DET 02870v8507t 15 6 requirement requirement NOUN 02870v8507t 15 7 for for ADP 02870v8507t 15 8 pkc pkc NOUN 02870v8507t 15 9 signaling signaling NOUN 02870v8507t 15 10 occurs occur VERB 02870v8507t 15 11 concurrent concurrent ADJ 02870v8507t 15 12 with with ADP 02870v8507t 15 13 follicle follicle NOUN 02870v8507t 15 14 selection selection NOUN 02870v8507t 15 15 , , PUNCT 02870v8507t 15 16 as as SCONJ 02870v8507t 15 17 cells cell NOUN 02870v8507t 15 18 treated treat VERB 02870v8507t 15 19 with with ADP 02870v8507t 15 20 a a DET 02870v8507t 15 21 pkc pkc ADJ 02870v8507t 15 22 inhibitor inhibitor NOUN 02870v8507t 15 23 in in ADP 02870v8507t 15 24 combination combination NOUN 02870v8507t 15 25 with with ADP 02870v8507t 15 26 gonadotropin gonadotropin PROPN 02870v8507t 15 27 failed fail VERB 02870v8507t 15 28 to to PART 02870v8507t 15 29 produce produce VERB 02870v8507t 15 30 progesterone progesterone NOUN 02870v8507t 15 31 in in ADP 02870v8507t 15 32 the the DET 02870v8507t 15 33 most most ADV 02870v8507t 15 34 recently recently ADV 02870v8507t 15 35 selected select VERB 02870v8507t 15 36 follicle follicle NOUN 02870v8507t 15 37 . . PUNCT 02870v8507t 16 1 in in ADP 02870v8507t 16 2 summary summary NOUN 02870v8507t 16 3 , , PUNCT 02870v8507t 16 4 these these DET 02870v8507t 16 5 data datum NOUN 02870v8507t 16 6 support support VERB 02870v8507t 16 7 the the DET 02870v8507t 16 8 hypothesis hypothesis NOUN 02870v8507t 16 9 that that SCONJ 02870v8507t 16 10 alleviation alleviation NOUN 02870v8507t 16 11 from from ADP 02870v8507t 16 12 inhibitory inhibitory ADJ 02870v8507t 16 13 signaling signaling NOUN 02870v8507t 16 14 is be AUX 02870v8507t 16 15 required require VERB 02870v8507t 16 16 for for ADP 02870v8507t 16 17 granulosa granulosa ADJ 02870v8507t 16 18 cell cell NOUN 02870v8507t 16 19 differentiation differentiation NOUN 02870v8507t 16 20 . . PUNCT 02870v8507t 17 1 however however ADV 02870v8507t 17 2 , , PUNCT 02870v8507t 17 3 these these DET 02870v8507t 17 4 results result NOUN 02870v8507t 17 5 also also ADV 02870v8507t 17 6 indicate indicate VERB 02870v8507t 17 7 that that SCONJ 02870v8507t 17 8 the the DET 02870v8507t 17 9 removal removal NOUN 02870v8507t 17 10 of of ADP 02870v8507t 17 11 inhibitory inhibitory ADJ 02870v8507t 17 12 signaling signaling NOUN 02870v8507t 17 13 is be AUX 02870v8507t 17 14 transient transient ADJ 02870v8507t 17 15 , , PUNCT 02870v8507t 17 16 as as SCONJ 02870v8507t 17 17 indicated indicate VERB 02870v8507t 17 18 by by ADP 02870v8507t 17 19 the the DET 02870v8507t 17 20 requirement requirement NOUN 02870v8507t 17 21 for for ADP 02870v8507t 17 22 erk erk PROPN 02870v8507t 17 23 and and CCONJ 02870v8507t 17 24 pkc pkc ADJ 02870v8507t 17 25 signaling signal VERB 02870v8507t 17 26 in in ADP 02870v8507t 17 27 the the DET 02870v8507t 17 28 latter latter ADJ 02870v8507t 17 29 , , PUNCT 02870v8507t 17 30 preovulatory preovulatory ADJ 02870v8507t 17 31 stage stage NOUN 02870v8507t 17 32 . . PUNCT