id sid tid token lemma pos 2801pg17w0b 1 1 in in ADP 2801pg17w0b 1 2 the the DET 2801pg17w0b 1 3 cell cell NOUN 2801pg17w0b 1 4 , , PUNCT 2801pg17w0b 1 5 proteins protein NOUN 2801pg17w0b 1 6 are be AUX 2801pg17w0b 1 7 synthesized synthesize VERB 2801pg17w0b 1 8 from from ADP 2801pg17w0b 1 9 nto nto ADP 2801pg17w0b 1 10 c c NOUN 2801pg17w0b 1 11 - - PUNCT 2801pg17w0b 1 12 terminus terminus NOUN 2801pg17w0b 1 13 by by ADP 2801pg17w0b 1 14 the the DET 2801pg17w0b 1 15 ribosome ribosome NOUN 2801pg17w0b 1 16 . . PUNCT 2801pg17w0b 2 1 once once ADV 2801pg17w0b 2 2 emerged emerge VERB 2801pg17w0b 2 3 from from ADP 2801pg17w0b 2 4 the the DET 2801pg17w0b 2 5 ribosome ribosome ADJ 2801pg17w0b 2 6 exit exit NOUN 2801pg17w0b 2 7 tunnel tunnel NOUN 2801pg17w0b 2 8 , , PUNCT 2801pg17w0b 2 9 the the DET 2801pg17w0b 2 10 nascent nascent ADJ 2801pg17w0b 2 11 chain chain NOUN 2801pg17w0b 2 12 can can AUX 2801pg17w0b 2 13 begin begin VERB 2801pg17w0b 2 14 to to PART 2801pg17w0b 2 15 fold fold VERB 2801pg17w0b 2 16 while while SCONJ 2801pg17w0b 2 17 its its PRON 2801pg17w0b 2 18 c c NOUN 2801pg17w0b 2 19 - - PUNCT 2801pg17w0b 2 20 terminus terminus NOUN 2801pg17w0b 2 21 is be AUX 2801pg17w0b 2 22 still still ADV 2801pg17w0b 2 23 untranslated untranslated ADJ 2801pg17w0b 2 24 or or CCONJ 2801pg17w0b 2 25 constrained constrain VERB 2801pg17w0b 2 26 inside inside ADP 2801pg17w0b 2 27 the the DET 2801pg17w0b 2 28 ribosome ribosome NOUN 2801pg17w0b 2 29 . . PUNCT 2801pg17w0b 3 1 the the DET 2801pg17w0b 3 2 conformations conformation NOUN 2801pg17w0b 3 3 of of ADP 2801pg17w0b 3 4 nascent nascent ADJ 2801pg17w0b 3 5 chains chain NOUN 2801pg17w0b 3 6 once once SCONJ 2801pg17w0b 3 7 they they PRON 2801pg17w0b 3 8 emerge emerge VERB 2801pg17w0b 3 9 from from ADP 2801pg17w0b 3 10 the the DET 2801pg17w0b 3 11 exit exit NOUN 2801pg17w0b 3 12 tunnel tunnel NOUN 2801pg17w0b 3 13 , , PUNCT 2801pg17w0b 3 14 but but CCONJ 2801pg17w0b 3 15 before before SCONJ 2801pg17w0b 3 16 an an DET 2801pg17w0b 3 17 entire entire ADJ 2801pg17w0b 3 18 structural structural ADJ 2801pg17w0b 3 19 domain domain NOUN 2801pg17w0b 3 20 has have AUX 2801pg17w0b 3 21 appeared appear VERB 2801pg17w0b 3 22 , , PUNCT 2801pg17w0b 3 23 are be AUX 2801pg17w0b 3 24 poorly poorly ADV 2801pg17w0b 3 25 understood understand VERB 2801pg17w0b 3 26 but but CCONJ 2801pg17w0b 3 27 are be AUX 2801pg17w0b 3 28 known know VERB 2801pg17w0b 3 29 to to PART 2801pg17w0b 3 30 affect affect VERB 2801pg17w0b 3 31 folding fold VERB 2801pg17w0b 3 32 pathways pathway NOUN 2801pg17w0b 3 33 and and CCONJ 2801pg17w0b 3 34 yield yield NOUN 2801pg17w0b 3 35 . . PUNCT 2801pg17w0b 4 1 translation translation NOUN 2801pg17w0b 4 2 rate rate NOUN 2801pg17w0b 4 3 can can AUX 2801pg17w0b 4 4 be be AUX 2801pg17w0b 4 5 slower slow ADJ 2801pg17w0b 4 6 than than ADP 2801pg17w0b 4 7 the the DET 2801pg17w0b 4 8 formation formation NOUN 2801pg17w0b 4 9 of of ADP 2801pg17w0b 4 10 stable stable ADJ 2801pg17w0b 4 11 secondary secondary ADJ 2801pg17w0b 4 12 and and CCONJ 2801pg17w0b 4 13 tertiary tertiary ADJ 2801pg17w0b 4 14 structure structure NOUN 2801pg17w0b 4 15 , , PUNCT 2801pg17w0b 4 16 meaning mean VERB 2801pg17w0b 4 17 that that SCONJ 2801pg17w0b 4 18 altering alter VERB 2801pg17w0b 4 19 translation translation NOUN 2801pg17w0b 4 20 rate rate NOUN 2801pg17w0b 4 21 could could AUX 2801pg17w0b 4 22 potentially potentially ADV 2801pg17w0b 4 23 influence influence VERB 2801pg17w0b 4 24 the the DET 2801pg17w0b 4 25 folding fold VERB 2801pg17w0b 4 26 pathway pathway NOUN 2801pg17w0b 4 27 and and CCONJ 2801pg17w0b 4 28 even even ADV 2801pg17w0b 4 29 the the DET 2801pg17w0b 4 30 final final ADJ 2801pg17w0b 4 31 , , PUNCT 2801pg17w0b 4 32 folded fold VERB 2801pg17w0b 4 33 structure structure NOUN 2801pg17w0b 4 34 of of ADP 2801pg17w0b 4 35 a a DET 2801pg17w0b 4 36 protein protein NOUN 2801pg17w0b 4 37 . . PUNCT 2801pg17w0b 5 1 synonymous synonymous ADJ 2801pg17w0b 5 2 codon codon NOUN 2801pg17w0b 5 3 substitutions substitution NOUN 2801pg17w0b 5 4 , , PUNCT 2801pg17w0b 5 5 which which PRON 2801pg17w0b 5 6 are be AUX 2801pg17w0b 5 7 known know VERB 2801pg17w0b 5 8 to to PART 2801pg17w0b 5 9 alter alter VERB 2801pg17w0b 5 10 local local ADJ 2801pg17w0b 5 11 elongation elongation NOUN 2801pg17w0b 5 12 rates rate NOUN 2801pg17w0b 5 13 , , PUNCT 2801pg17w0b 5 14 have have AUX 2801pg17w0b 5 15 been be AUX 2801pg17w0b 5 16 shown show VERB 2801pg17w0b 5 17 to to PART 2801pg17w0b 5 18 affect affect VERB 2801pg17w0b 5 19 the the DET 2801pg17w0b 5 20 final final ADJ 2801pg17w0b 5 21 structure structure NOUN 2801pg17w0b 5 22 of of ADP 2801pg17w0b 5 23 certain certain ADJ 2801pg17w0b 5 24 proteins protein NOUN 2801pg17w0b 5 25 . . PUNCT 2801pg17w0b 6 1 however however ADV 2801pg17w0b 6 2 , , PUNCT 2801pg17w0b 6 3 the the DET 2801pg17w0b 6 4 effects effect NOUN 2801pg17w0b 6 5 of of ADP 2801pg17w0b 6 6 non non ADJ 2801pg17w0b 6 7 - - ADJ 2801pg17w0b 6 8 synonymous synonymous ADJ 2801pg17w0b 6 9 mutations mutation NOUN 2801pg17w0b 6 10 have have AUX 2801pg17w0b 6 11 not not PART 2801pg17w0b 6 12 been be AUX 2801pg17w0b 6 13 explored explore VERB 2801pg17w0b 6 14 . . PUNCT 2801pg17w0b 7 1 in in ADP 2801pg17w0b 7 2 this this DET 2801pg17w0b 7 3 thesis thesis NOUN 2801pg17w0b 7 4 , , PUNCT 2801pg17w0b 7 5 i i PRON 2801pg17w0b 7 6 show show VERB 2801pg17w0b 7 7 that that SCONJ 2801pg17w0b 7 8 non non ADJ 2801pg17w0b 7 9 - - ADJ 2801pg17w0b 7 10 synonymous synonymous ADJ 2801pg17w0b 7 11 mutations mutation NOUN 2801pg17w0b 7 12 known know VERB 2801pg17w0b 7 13 to to PART 2801pg17w0b 7 14 affect affect VERB 2801pg17w0b 7 15 translation translation NOUN 2801pg17w0b 7 16 rate rate NOUN 2801pg17w0b 7 17 can can AUX 2801pg17w0b 7 18 predictably predictably ADV 2801pg17w0b 7 19 alter alter VERB 2801pg17w0b 7 20 the the DET 2801pg17w0b 7 21 folded fold VERB 2801pg17w0b 7 22 state state NOUN 2801pg17w0b 7 23 of of ADP 2801pg17w0b 7 24 a a DET 2801pg17w0b 7 25 protein protein NOUN 2801pg17w0b 7 26 biosensor biosensor NOUN 2801pg17w0b 7 27 . . PUNCT 2801pg17w0b 8 1 additionally additionally ADV 2801pg17w0b 8 2 , , PUNCT 2801pg17w0b 8 3 a a DET 2801pg17w0b 8 4 novel novel ADJ 2801pg17w0b 8 5 translation translation NOUN 2801pg17w0b 8 6 stall stall NOUN 2801pg17w0b 8 7 sequence sequence NOUN 2801pg17w0b 8 8 composed compose VERB 2801pg17w0b 8 9 of of ADP 2801pg17w0b 8 10 amino amino ADJ 2801pg17w0b 8 11 acids acid NOUN 2801pg17w0b 8 12 and and CCONJ 2801pg17w0b 8 13 stop stop VERB 2801pg17w0b 8 14 codon codon NOUN 2801pg17w0b 8 15 usage usage NOUN 2801pg17w0b 8 16 components component NOUN 2801pg17w0b 8 17 is be AUX 2801pg17w0b 8 18 characterized.in characterized.in X 2801pg17w0b 8 19 addition addition NOUN 2801pg17w0b 8 20 to to ADP 2801pg17w0b 8 21 its its PRON 2801pg17w0b 8 22 effects effect NOUN 2801pg17w0b 8 23 on on ADP 2801pg17w0b 8 24 protein protein NOUN 2801pg17w0b 8 25 folding fold VERB 2801pg17w0b 8 26 , , PUNCT 2801pg17w0b 8 27 stalling stalling NOUN 2801pg17w0b 8 28 of of ADP 2801pg17w0b 8 29 translation translation NOUN 2801pg17w0b 8 30 elongation elongation NOUN 2801pg17w0b 8 31 can can AUX 2801pg17w0b 8 32 also also ADV 2801pg17w0b 8 33 lead lead VERB 2801pg17w0b 8 34 to to ADP 2801pg17w0b 8 35 the the DET 2801pg17w0b 8 36 degradation degradation NOUN 2801pg17w0b 8 37 of of ADP 2801pg17w0b 8 38 nascent nascent ADJ 2801pg17w0b 8 39 polypeptides polypeptide NOUN 2801pg17w0b 8 40 in in ADP 2801pg17w0b 8 41 both both DET 2801pg17w0b 8 42 prokaryotes prokaryote NOUN 2801pg17w0b 8 43 and and CCONJ 2801pg17w0b 8 44 eukaryotes eukaryote NOUN 2801pg17w0b 8 45 . . PUNCT 2801pg17w0b 9 1 protease protease NOUN 2801pg17w0b 9 2 degradation degradation NOUN 2801pg17w0b 9 3 of of ADP 2801pg17w0b 9 4 these these DET 2801pg17w0b 9 5 stalled stall VERB 2801pg17w0b 9 6 nascent nascent ADJ 2801pg17w0b 9 7 polypeptides polypeptide NOUN 2801pg17w0b 9 8 requires require VERB 2801pg17w0b 9 9 addition addition NOUN 2801pg17w0b 9 10 of of ADP 2801pg17w0b 9 11 a a DET 2801pg17w0b 9 12 peptide peptide NOUN 2801pg17w0b 9 13 tag tag NOUN 2801pg17w0b 9 14 by by ADP 2801pg17w0b 9 15 quality quality NOUN 2801pg17w0b 9 16 control control NOUN 2801pg17w0b 9 17 machinery machinery NOUN 2801pg17w0b 9 18 . . PUNCT 2801pg17w0b 10 1 i i PRON 2801pg17w0b 10 2 demonstrate demonstrate VERB 2801pg17w0b 10 3 that that SCONJ 2801pg17w0b 10 4 the the DET 2801pg17w0b 10 5 fragmentation fragmentation NOUN 2801pg17w0b 10 6 of of ADP 2801pg17w0b 10 7 a a DET 2801pg17w0b 10 8 model model NOUN 2801pg17w0b 10 9 protein protein NOUN 2801pg17w0b 10 10 is be AUX 2801pg17w0b 10 11 controlled control VERB 2801pg17w0b 10 12 by by ADP 2801pg17w0b 10 13 both both DET 2801pg17w0b 10 14 its its PRON 2801pg17w0b 10 15 translation translation NOUN 2801pg17w0b 10 16 rate rate NOUN 2801pg17w0b 10 17 and and CCONJ 2801pg17w0b 10 18 its its PRON 2801pg17w0b 10 19 c c ADJ 2801pg17w0b 10 20 - - PUNCT 2801pg17w0b 10 21 terminal terminal ADJ 2801pg17w0b 10 22 sequence sequence NOUN 2801pg17w0b 10 23 polarity polarity NOUN 2801pg17w0b 10 24 . . PUNCT 2801pg17w0b 11 1 the the DET 2801pg17w0b 11 2 conformations conformation NOUN 2801pg17w0b 11 3 nascent nascent ADJ 2801pg17w0b 11 4 polypeptide polypeptide NOUN 2801pg17w0b 11 5 chains chain NOUN 2801pg17w0b 11 6 adopt adopt VERB 2801pg17w0b 11 7 while while SCONJ 2801pg17w0b 11 8 still still ADV 2801pg17w0b 11 9 tethered tether VERB 2801pg17w0b 11 10 to to ADP 2801pg17w0b 11 11 the the DET 2801pg17w0b 11 12 ribosome ribosome NOUN 2801pg17w0b 11 13 are be AUX 2801pg17w0b 11 14 not not PART 2801pg17w0b 11 15 well well ADV 2801pg17w0b 11 16 - - PUNCT 2801pg17w0b 11 17 characterized characterize VERB 2801pg17w0b 11 18 . . PUNCT 2801pg17w0b 12 1 the the DET 2801pg17w0b 12 2 conformations conformation NOUN 2801pg17w0b 12 3 of of ADP 2801pg17w0b 12 4 proteins protein NOUN 2801pg17w0b 12 5 composed compose VERB 2801pg17w0b 12 6 of of ADP 2801pg17w0b 12 7 primarily primarily ADV 2801pg17w0b 12 8 β β NUM 2801pg17w0b 12 9 - - PUNCT 2801pg17w0b 12 10 sheet sheet NOUN 2801pg17w0b 12 11 structure structure NOUN 2801pg17w0b 12 12 , , PUNCT 2801pg17w0b 12 13 which which PRON 2801pg17w0b 12 14 contains contain VERB 2801pg17w0b 12 15 many many ADJ 2801pg17w0b 12 16 long long ADJ 2801pg17w0b 12 17 - - PUNCT 2801pg17w0b 12 18 range range NOUN 2801pg17w0b 12 19 interactions interaction NOUN 2801pg17w0b 12 20 , , PUNCT 2801pg17w0b 12 21 are be AUX 2801pg17w0b 12 22 particularly particularly ADV 2801pg17w0b 12 23 unknown unknown ADJ 2801pg17w0b 12 24 . . PUNCT 2801pg17w0b 13 1 here here ADV 2801pg17w0b 13 2 , , PUNCT 2801pg17w0b 13 3 i i PRON 2801pg17w0b 13 4 describe describe VERB 2801pg17w0b 13 5 the the DET 2801pg17w0b 13 6 development development NOUN 2801pg17w0b 13 7 of of ADP 2801pg17w0b 13 8 a a DET 2801pg17w0b 13 9 technique technique NOUN 2801pg17w0b 13 10 to to PART 2801pg17w0b 13 11 probe probe VERB 2801pg17w0b 13 12 the the DET 2801pg17w0b 13 13 surface surface NOUN 2801pg17w0b 13 14 exposure exposure NOUN 2801pg17w0b 13 15 of of ADP 2801pg17w0b 13 16 a a DET 2801pg17w0b 13 17 model model NOUN 2801pg17w0b 13 18 β β NOUN 2801pg17w0b 13 19 - - PUNCT 2801pg17w0b 13 20 sheet sheet NOUN 2801pg17w0b 13 21 protein protein NOUN 2801pg17w0b 13 22 ( ( PUNCT 2801pg17w0b 13 23 gfp gfp NOUN 2801pg17w0b 13 24 ) ) PUNCT 2801pg17w0b 13 25 on on ADP 2801pg17w0b 13 26 the the DET 2801pg17w0b 13 27 ribosome ribosome NOUN 2801pg17w0b 13 28 using use VERB 2801pg17w0b 13 29 covalent covalent NOUN 2801pg17w0b 13 30 labeling labeling NOUN 2801pg17w0b 13 31 of of ADP 2801pg17w0b 13 32 ribosome ribosome ADJ 2801pg17w0b 13 33 - - PUNCT 2801pg17w0b 13 34 gfp gfp NOUN 2801pg17w0b 13 35 - - PUNCT 2801pg17w0b 13 36 nascent nascent ADJ 2801pg17w0b 13 37 chain chain NOUN 2801pg17w0b 13 38 complexes complex NOUN 2801pg17w0b 13 39 coupled couple VERB 2801pg17w0b 13 40 to to ADP 2801pg17w0b 13 41 mass mass ADJ 2801pg17w0b 13 42 spectrometry spectrometry NOUN 2801pg17w0b 13 43 . . PUNCT 2801pg17w0b 14 1 a a DET 2801pg17w0b 14 2 method method NOUN 2801pg17w0b 14 3 to to PART 2801pg17w0b 14 4 isolate isolate VERB 2801pg17w0b 14 5 ribosome ribosome ADJ 2801pg17w0b 14 6 - - PUNCT 2801pg17w0b 14 7 nascent nascent ADJ 2801pg17w0b 14 8 chain chain NOUN 2801pg17w0b 14 9 complexes complex NOUN 2801pg17w0b 14 10 from from ADP 2801pg17w0b 14 11 released release VERB 2801pg17w0b 14 12 gfp gfp NOUN 2801pg17w0b 14 13 was be AUX 2801pg17w0b 14 14 presented present VERB 2801pg17w0b 14 15 and and CCONJ 2801pg17w0b 14 16 the the DET 2801pg17w0b 14 17 association association NOUN 2801pg17w0b 14 18 of of ADP 2801pg17w0b 14 19 nascent nascent PROPN 2801pg17w0b 14 20 gfp gfp PROPN 2801pg17w0b 14 21 with with ADP 2801pg17w0b 14 22 the the DET 2801pg17w0b 14 23 ribosome ribosome NOUN 2801pg17w0b 14 24 in in ADP 2801pg17w0b 14 25 the the DET 2801pg17w0b 14 26 complexes complex NOUN 2801pg17w0b 14 27 was be AUX 2801pg17w0b 14 28 verified verify VERB 2801pg17w0b 14 29 . . PUNCT