id sid tid token lemma pos 3197xk83g21 1 1 phosphoproteomics phosphoproteomics PROPN 3197xk83g21 1 2 is be AUX 3197xk83g21 1 3 a a DET 3197xk83g21 1 4 valuable valuable ADJ 3197xk83g21 1 5 tool tool NOUN 3197xk83g21 1 6 for for ADP 3197xk83g21 1 7 mapping map VERB 3197xk83g21 1 8 molecular molecular ADJ 3197xk83g21 1 9 signaling signal VERB 3197xk83g21 1 10 events event NOUN 3197xk83g21 1 11 and and CCONJ 3197xk83g21 1 12 dissecting dissect VERB 3197xk83g21 1 13 the the DET 3197xk83g21 1 14 interactions interaction NOUN 3197xk83g21 1 15 among among ADP 3197xk83g21 1 16 biological biological ADJ 3197xk83g21 1 17 pathways pathway NOUN 3197xk83g21 1 18 . . PUNCT 3197xk83g21 2 1 despite despite SCONJ 3197xk83g21 2 2 many many ADJ 3197xk83g21 2 3 advances advance NOUN 3197xk83g21 2 4 in in ADP 3197xk83g21 2 5 the the DET 3197xk83g21 2 6 sample sample NOUN 3197xk83g21 2 7 preparation preparation NOUN 3197xk83g21 2 8 methods method NOUN 3197xk83g21 2 9 and and CCONJ 3197xk83g21 2 10 instrument instrument NOUN 3197xk83g21 2 11 technologies technology NOUN 3197xk83g21 2 12 used use VERB 3197xk83g21 2 13 for for ADP 3197xk83g21 2 14 liquid liquid ADJ 3197xk83g21 2 15 chromatography chromatography NOUN 3197xk83g21 2 16 – – PUNCT 3197xk83g21 2 17 mass mass NOUN 3197xk83g21 2 18 spectrometry spectrometry NOUN 3197xk83g21 2 19 analyses analysis NOUN 3197xk83g21 2 20 of of ADP 3197xk83g21 2 21 protein protein NOUN 3197xk83g21 2 22 phosphorylation phosphorylation NOUN 3197xk83g21 2 23 , , PUNCT 3197xk83g21 2 24 there there PRON 3197xk83g21 2 25 is be VERB 3197xk83g21 2 26 still still ADV 3197xk83g21 2 27 a a DET 3197xk83g21 2 28 lack lack NOUN 3197xk83g21 2 29 of of ADP 3197xk83g21 2 30 consensus consensus NOUN 3197xk83g21 2 31 regarding regard VERB 3197xk83g21 2 32 best good ADJ 3197xk83g21 2 33 practices practice NOUN 3197xk83g21 2 34 in in ADP 3197xk83g21 2 35 this this DET 3197xk83g21 2 36 field field NOUN 3197xk83g21 2 37 . . PUNCT 3197xk83g21 3 1 in in ADP 3197xk83g21 3 2 particular particular ADJ 3197xk83g21 3 3 , , PUNCT 3197xk83g21 3 4 the the DET 3197xk83g21 3 5 chemistry chemistry NOUN 3197xk83g21 3 6 used use VERB 3197xk83g21 3 7 to to PART 3197xk83g21 3 8 enrich enrich VERB 3197xk83g21 3 9 phosphopeptides phosphopeptide NOUN 3197xk83g21 3 10 from from ADP 3197xk83g21 3 11 complex complex ADJ 3197xk83g21 3 12 cell cell NOUN 3197xk83g21 3 13 lysates lysate NOUN 3197xk83g21 3 14 is be AUX 3197xk83g21 3 15 especially especially ADV 3197xk83g21 3 16 critical critical ADJ 3197xk83g21 3 17 to to ADP 3197xk83g21 3 18 a a DET 3197xk83g21 3 19 comprehensive comprehensive ADJ 3197xk83g21 3 20 , , PUNCT 3197xk83g21 3 21 sensitive sensitive ADJ 3197xk83g21 3 22 , , PUNCT 3197xk83g21 3 23 and and CCONJ 3197xk83g21 3 24 accurate accurate ADJ 3197xk83g21 3 25 phosphoproteomics phosphoproteomic NOUN 3197xk83g21 3 26 experiment experiment NOUN 3197xk83g21 3 27 . . PUNCT 3197xk83g21 4 1 this this DET 3197xk83g21 4 2 dissertation dissertation NOUN 3197xk83g21 4 3 compared compare VERB 3197xk83g21 4 4 two two NUM 3197xk83g21 4 5 popular popular ADJ 3197xk83g21 4 6 phosphoproteomics phosphoproteomic NOUN 3197xk83g21 4 7 enrichment enrichment NOUN 3197xk83g21 4 8 methods method NOUN 3197xk83g21 4 9 , , PUNCT 3197xk83g21 4 10 immobilized immobilize VERB 3197xk83g21 4 11 metal metal NOUN 3197xk83g21 4 12 affinity affinity NOUN 3197xk83g21 4 13 chromatography chromatography NOUN 3197xk83g21 4 14 ( ( PUNCT 3197xk83g21 4 15 imac imac NOUN 3197xk83g21 4 16 ) ) PUNCT 3197xk83g21 4 17 and and CCONJ 3197xk83g21 4 18 titanium titanium NOUN 3197xk83g21 4 19 dioxide dioxide NOUN 3197xk83g21 4 20 ( ( PUNCT 3197xk83g21 4 21 tio2)-based tio2)-base VERB 3197xk83g21 4 22 metal metal NOUN 3197xk83g21 4 23 oxide oxide NOUN 3197xk83g21 4 24 affinity affinity NOUN 3197xk83g21 4 25 chromatography chromatography NOUN 3197xk83g21 4 26 ( ( PUNCT 3197xk83g21 4 27 moac moac PROPN 3197xk83g21 4 28 ) ) PUNCT 3197xk83g21 4 29 . . PUNCT 3197xk83g21 5 1 a a DET 3197xk83g21 5 2 multi multi ADJ 3197xk83g21 5 3 - - ADJ 3197xk83g21 5 4 step step NOUN 3197xk83g21 5 5 enrichment enrichment NOUN 3197xk83g21 5 6 protocol protocol NOUN 3197xk83g21 5 7 incorporating incorporate VERB 3197xk83g21 5 8 benchtop benchtop NOUN 3197xk83g21 5 9 high high ADJ 3197xk83g21 5 10 - - PUNCT 3197xk83g21 5 11 ph ph NOUN 3197xk83g21 5 12 reverse reverse ADJ 3197xk83g21 5 13 phase phase NOUN 3197xk83g21 5 14 fractionation fractionation NOUN 3197xk83g21 5 15 , , PUNCT 3197xk83g21 5 16 developed develop VERB 3197xk83g21 5 17 in in ADP 3197xk83g21 5 18 the the DET 3197xk83g21 5 19 hummon hummon PROPN 3197xk83g21 5 20 lab lab PROPN 3197xk83g21 5 21 , , PUNCT 3197xk83g21 5 22 minimizes minimize VERB 3197xk83g21 5 23 the the DET 3197xk83g21 5 24 amount amount NOUN 3197xk83g21 5 25 of of ADP 3197xk83g21 5 26 peptide peptide NOUN 3197xk83g21 5 27 starting start VERB 3197xk83g21 5 28 material material NOUN 3197xk83g21 5 29 required require VERB 3197xk83g21 5 30 for for ADP 3197xk83g21 5 31 maximal maximal ADJ 3197xk83g21 5 32 recovery recovery NOUN 3197xk83g21 5 33 from from ADP 3197xk83g21 5 34 both both DET 3197xk83g21 5 35 imac imac NOUN 3197xk83g21 5 36 and and CCONJ 3197xk83g21 5 37 tio2 tio2 PROPN 3197xk83g21 5 38 . . PUNCT 3197xk83g21 6 1 the the DET 3197xk83g21 6 2 two two NUM 3197xk83g21 6 3 chemistries chemistry NOUN 3197xk83g21 6 4 were be AUX 3197xk83g21 6 5 found find VERB 3197xk83g21 6 6 to to PART 3197xk83g21 6 7 enrich enrich VERB 3197xk83g21 6 8 phosphopeptides phosphopeptide NOUN 3197xk83g21 6 9 equally equally ADV 3197xk83g21 6 10 well well ADV 3197xk83g21 6 11 , , PUNCT 3197xk83g21 6 12 but but CCONJ 3197xk83g21 6 13 favor favor VERB 3197xk83g21 6 14 unique unique ADJ 3197xk83g21 6 15 subgroups subgroup NOUN 3197xk83g21 6 16 of of ADP 3197xk83g21 6 17 peptides peptide NOUN 3197xk83g21 6 18 . . PUNCT 3197xk83g21 7 1 tio2 tio2 NOUN 3197xk83g21 7 2 enriches enrich VERB 3197xk83g21 7 3 peptides peptide NOUN 3197xk83g21 7 4 that that PRON 3197xk83g21 7 5 are be AUX 3197xk83g21 7 6 slightly slightly ADV 3197xk83g21 7 7 shorter short ADJ 3197xk83g21 7 8 , , PUNCT 3197xk83g21 7 9 more more ADV 3197xk83g21 7 10 acidic acidic ADJ 3197xk83g21 7 11 , , PUNCT 3197xk83g21 7 12 and and CCONJ 3197xk83g21 7 13 more more ADJ 3197xk83g21 7 14 hydrophobic hydrophobic NOUN 3197xk83g21 7 15 than than ADP 3197xk83g21 7 16 imac imac NOUN 3197xk83g21 7 17 does do VERB 3197xk83g21 7 18 . . PUNCT 3197xk83g21 8 1 the the DET 3197xk83g21 8 2 improved improved ADJ 3197xk83g21 8 3 enrichment enrichment NOUN 3197xk83g21 8 4 protocol protocol NOUN 3197xk83g21 8 5 was be AUX 3197xk83g21 8 6 applied apply VERB 3197xk83g21 8 7 to to ADP 3197xk83g21 8 8 two two NUM 3197xk83g21 8 9 cancer cancer NOUN 3197xk83g21 8 10 - - PUNCT 3197xk83g21 8 11 relevant relevant ADJ 3197xk83g21 8 12 signaling signal VERB 3197xk83g21 8 13 networks network NOUN 3197xk83g21 8 14 . . PUNCT 3197xk83g21 9 1 the the DET 3197xk83g21 9 2 first first ADV 3197xk83g21 9 3 examined examine VERB 3197xk83g21 9 4 constitutive constitutive ADJ 3197xk83g21 9 5 phosphorylation phosphorylation NOUN 3197xk83g21 9 6 differences difference NOUN 3197xk83g21 9 7 between between ADP 3197xk83g21 9 8 a a DET 3197xk83g21 9 9 primary primary ADJ 3197xk83g21 9 10 tumor tumor NOUN 3197xk83g21 9 11 - - PUNCT 3197xk83g21 9 12 derived derive VERB 3197xk83g21 9 13 cell cell NOUN 3197xk83g21 9 14 line line NOUN 3197xk83g21 9 15 and and CCONJ 3197xk83g21 9 16 its its PRON 3197xk83g21 9 17 patient patient NOUN 3197xk83g21 9 18 - - PUNCT 3197xk83g21 9 19 matched match VERB 3197xk83g21 9 20 lymph lymph NOUN 3197xk83g21 9 21 node node NOUN 3197xk83g21 9 22 metastasis metastasis NOUN 3197xk83g21 9 23 cell cell NOUN 3197xk83g21 9 24 line line NOUN 3197xk83g21 9 25 . . PUNCT 3197xk83g21 10 1 this this DET 3197xk83g21 10 2 study study NOUN 3197xk83g21 10 3 of of ADP 3197xk83g21 10 4 the the DET 3197xk83g21 10 5 phosphoproteomes phosphoproteome NOUN 3197xk83g21 10 6 of of ADP 3197xk83g21 10 7 sw480 sw480 PROPN 3197xk83g21 10 8 and and CCONJ 3197xk83g21 10 9 sw620 sw620 PROPN 3197xk83g21 10 10 revealed reveal VERB 3197xk83g21 10 11 that that SCONJ 3197xk83g21 10 12 the the DET 3197xk83g21 10 13 lines line NOUN 3197xk83g21 10 14 differ differ VERB 3197xk83g21 10 15 significantly significantly ADV 3197xk83g21 10 16 in in ADP 3197xk83g21 10 17 their their PRON 3197xk83g21 10 18 regulation regulation NOUN 3197xk83g21 10 19 of of ADP 3197xk83g21 10 20 cellular cellular ADJ 3197xk83g21 10 21 adhesion adhesion NOUN 3197xk83g21 10 22 , , PUNCT 3197xk83g21 10 23 mitosis mitosis NOUN 3197xk83g21 10 24 , , PUNCT 3197xk83g21 10 25 and and CCONJ 3197xk83g21 10 26 mrna mrna PROPN 3197xk83g21 10 27 translation translation NOUN 3197xk83g21 10 28 . . PUNCT 3197xk83g21 11 1 in in ADP 3197xk83g21 11 2 the the DET 3197xk83g21 11 3 second second ADJ 3197xk83g21 11 4 study study NOUN 3197xk83g21 11 5 , , PUNCT 3197xk83g21 11 6 a a DET 3197xk83g21 11 7 single single ADJ 3197xk83g21 11 8 - - PUNCT 3197xk83g21 11 9 step step NOUN 3197xk83g21 11 10 tio2 tio2 NOUN 3197xk83g21 11 11 enrichment enrichment NOUN 3197xk83g21 11 12 allowed allow VERB 3197xk83g21 11 13 characterization characterization NOUN 3197xk83g21 11 14 of of ADP 3197xk83g21 11 15 signaling signal VERB 3197xk83g21 11 16 networks network NOUN 3197xk83g21 11 17 affected affect VERB 3197xk83g21 11 18 by by ADP 3197xk83g21 11 19 low low ADJ 3197xk83g21 11 20 dose dose NOUN 3197xk83g21 11 21 and and CCONJ 3197xk83g21 11 22 high high ADJ 3197xk83g21 11 23 dose dose NOUN 3197xk83g21 11 24 ionizing ionize VERB 3197xk83g21 11 25 radiation radiation NOUN 3197xk83g21 11 26 in in ADP 3197xk83g21 11 27 non non ADJ 3197xk83g21 11 28 - - ADJ 3197xk83g21 11 29 malignant malignant ADJ 3197xk83g21 11 30 breast breast NOUN 3197xk83g21 11 31 cell cell NOUN 3197xk83g21 11 32 line line NOUN 3197xk83g21 11 33 mcf10a mcf10a SPACE 3197xk83g21 11 34 . . PUNCT 3197xk83g21 12 1 this this PRON 3197xk83g21 12 2 revealed reveal VERB 3197xk83g21 12 3 that that SCONJ 3197xk83g21 12 4 atm atm PROPN 3197xk83g21 12 5 & & CCONJ 3197xk83g21 12 6 amp amp PROPN 3197xk83g21 12 7 ; ; PUNCT 3197xk83g21 12 8 dnapk dnapk PROPN 3197xk83g21 12 9 kinases kinase NOUN 3197xk83g21 12 10 are be AUX 3197xk83g21 12 11 induced induce VERB 3197xk83g21 12 12 by by ADP 3197xk83g21 12 13 10 10 NUM 3197xk83g21 12 14 gy gy NOUN 3197xk83g21 12 15 of of ADP 3197xk83g21 12 16 γ γ NOUN 3197xk83g21 12 17 - - PUNCT 3197xk83g21 12 18 rays ray NOUN 3197xk83g21 12 19 but but CCONJ 3197xk83g21 12 20 not not PART 3197xk83g21 12 21 0.05 0.05 NUM 3197xk83g21 12 22 gy gy NOUN 3197xk83g21 12 23 . . PUNCT 3197xk83g21 13 1 in in ADP 3197xk83g21 13 2 contrast contrast NOUN 3197xk83g21 13 3 , , PUNCT 3197xk83g21 13 4 the the DET 3197xk83g21 13 5 mapk mapk NOUN 3197xk83g21 13 6 signaling signal VERB 3197xk83g21 13 7 response response NOUN 3197xk83g21 13 8 to to ADP 3197xk83g21 13 9 ir ir VERB 3197xk83g21 13 10 was be AUX 3197xk83g21 13 11 dose dose NOUN 3197xk83g21 13 12 - - PUNCT 3197xk83g21 13 13 independent independent ADJ 3197xk83g21 13 14 . . PUNCT 3197xk83g21 14 1 taken take VERB 3197xk83g21 14 2 together together ADV 3197xk83g21 14 3 , , PUNCT 3197xk83g21 14 4 this this DET 3197xk83g21 14 5 work work NOUN 3197xk83g21 14 6 demonstrates demonstrate VERB 3197xk83g21 14 7 the the DET 3197xk83g21 14 8 utility utility NOUN 3197xk83g21 14 9 of of ADP 3197xk83g21 14 10 the the DET 3197xk83g21 14 11 imac imac NOUN 3197xk83g21 14 12 – – PUNCT 3197xk83g21 14 13 tio2 tio2 NOUN 3197xk83g21 14 14 – – PUNCT 3197xk83g21 14 15 high high ADJ 3197xk83g21 14 16 ph ph NOUN 3197xk83g21 14 17 reverse reverse ADJ 3197xk83g21 14 18 phase phase NOUN 3197xk83g21 14 19 workflow workflow NOUN 3197xk83g21 14 20 to to PART 3197xk83g21 14 21 maximize maximize VERB 3197xk83g21 14 22 phosphoproteome phosphoproteome ADJ 3197xk83g21 14 23 coverage coverage NOUN 3197xk83g21 14 24 and and CCONJ 3197xk83g21 14 25 to to PART 3197xk83g21 14 26 generate generate VERB 3197xk83g21 14 27 novel novel ADJ 3197xk83g21 14 28 biological biological ADJ 3197xk83g21 14 29 insights insight NOUN 3197xk83g21 14 30 . . PUNCT