id sid tid token lemma pos 3197xk84g5b 1 1 kidney kidney NOUN 3197xk84g5b 1 2 disease disease NOUN 3197xk84g5b 1 3 is be AUX 3197xk84g5b 1 4 a a DET 3197xk84g5b 1 5 devastating devastating ADJ 3197xk84g5b 1 6 condition condition NOUN 3197xk84g5b 1 7 affecting affect VERB 3197xk84g5b 1 8 millions million NOUN 3197xk84g5b 1 9 of of ADP 3197xk84g5b 1 10 people people NOUN 3197xk84g5b 1 11 worldwide worldwide ADV 3197xk84g5b 1 12 , , PUNCT 3197xk84g5b 1 13 where where SCONJ 3197xk84g5b 1 14 over over ADP 3197xk84g5b 1 15 100,000 100,000 NUM 3197xk84g5b 1 16 patients patient NOUN 3197xk84g5b 1 17 in in ADP 3197xk84g5b 1 18 the the DET 3197xk84g5b 1 19 united united PROPN 3197xk84g5b 1 20 states states PROPN 3197xk84g5b 1 21 alone alone ADV 3197xk84g5b 1 22 remain remain VERB 3197xk84g5b 1 23 waiting wait VERB 3197xk84g5b 1 24 for for ADP 3197xk84g5b 1 25 a a DET 3197xk84g5b 1 26 lifesaving lifesaving NOUN 3197xk84g5b 1 27 organ organ NOUN 3197xk84g5b 1 28 transplant transplant NOUN 3197xk84g5b 1 29 . . PUNCT 3197xk84g5b 2 1 concomitant concomitant NOUN 3197xk84g5b 2 2 with with ADP 3197xk84g5b 2 3 a a DET 3197xk84g5b 2 4 surge surge NOUN 3197xk84g5b 2 5 in in ADP 3197xk84g5b 2 6 personalized personalized ADJ 3197xk84g5b 2 7 medicine medicine NOUN 3197xk84g5b 2 8 , , PUNCT 3197xk84g5b 2 9 single single ADJ 3197xk84g5b 2 10 - - PUNCT 3197xk84g5b 2 11 gene gene NOUN 3197xk84g5b 2 12 mutations mutation NOUN 3197xk84g5b 2 13 and and CCONJ 3197xk84g5b 2 14 polygenic polygenic ADJ 3197xk84g5b 2 15 risk risk NOUN 3197xk84g5b 2 16 alleles allele NOUN 3197xk84g5b 2 17 have have AUX 3197xk84g5b 2 18 been be AUX 3197xk84g5b 2 19 brought bring VERB 3197xk84g5b 2 20 to to ADP 3197xk84g5b 2 21 the the DET 3197xk84g5b 2 22 forefront forefront NOUN 3197xk84g5b 2 23 as as ADP 3197xk84g5b 2 24 core core NOUN 3197xk84g5b 2 25 causes cause NOUN 3197xk84g5b 2 26 of of ADP 3197xk84g5b 2 27 a a DET 3197xk84g5b 2 28 spectrum spectrum NOUN 3197xk84g5b 2 29 of of ADP 3197xk84g5b 2 30 renal renal ADJ 3197xk84g5b 2 31 disorders disorder NOUN 3197xk84g5b 2 32 . . PUNCT 3197xk84g5b 3 1 due due ADP 3197xk84g5b 3 2 to to ADP 3197xk84g5b 3 3 the the DET 3197xk84g5b 3 4 increasing increase VERB 3197xk84g5b 3 5 prevalence prevalence NOUN 3197xk84g5b 3 6 of of ADP 3197xk84g5b 3 7 kidney kidney NOUN 3197xk84g5b 3 8 disease disease NOUN 3197xk84g5b 3 9 , , PUNCT 3197xk84g5b 3 10 it it PRON 3197xk84g5b 3 11 is be AUX 3197xk84g5b 3 12 imperative imperative ADJ 3197xk84g5b 3 13 to to PART 3197xk84g5b 3 14 make make VERB 3197xk84g5b 3 15 substantial substantial ADJ 3197xk84g5b 3 16 strides stride NOUN 3197xk84g5b 3 17 in in ADP 3197xk84g5b 3 18 the the DET 3197xk84g5b 3 19 field field NOUN 3197xk84g5b 3 20 of of ADP 3197xk84g5b 3 21 kidney kidney NOUN 3197xk84g5b 3 22 genetics genetic NOUN 3197xk84g5b 3 23 . . PUNCT 3197xk84g5b 4 1 nephrons nephron NOUN 3197xk84g5b 4 2 , , PUNCT 3197xk84g5b 4 3 the the DET 3197xk84g5b 4 4 core core ADJ 3197xk84g5b 4 5 functional functional ADJ 3197xk84g5b 4 6 units unit NOUN 3197xk84g5b 4 7 of of ADP 3197xk84g5b 4 8 the the DET 3197xk84g5b 4 9 kidney kidney NOUN 3197xk84g5b 4 10 , , PUNCT 3197xk84g5b 4 11 are be AUX 3197xk84g5b 4 12 epithelial epithelial ADJ 3197xk84g5b 4 13 tubules tubule NOUN 3197xk84g5b 4 14 that that PRON 3197xk84g5b 4 15 act act VERB 3197xk84g5b 4 16 as as ADP 3197xk84g5b 4 17 gatekeepers gatekeeper NOUN 3197xk84g5b 4 18 of of ADP 3197xk84g5b 4 19 body body NOUN 3197xk84g5b 4 20 homeostasis homeostasis NOUN 3197xk84g5b 4 21 by by ADP 3197xk84g5b 4 22 absorbing absorb VERB 3197xk84g5b 4 23 and and CCONJ 3197xk84g5b 4 24 secreting secrete VERB 3197xk84g5b 4 25 ions ion NOUN 3197xk84g5b 4 26 , , PUNCT 3197xk84g5b 4 27 water water NOUN 3197xk84g5b 4 28 , , PUNCT 3197xk84g5b 4 29 and and CCONJ 3197xk84g5b 4 30 small small ADJ 3197xk84g5b 4 31 molecules molecule NOUN 3197xk84g5b 4 32 to to PART 3197xk84g5b 4 33 filter filter VERB 3197xk84g5b 4 34 the the DET 3197xk84g5b 4 35 blood blood NOUN 3197xk84g5b 4 36 . . PUNCT 3197xk84g5b 5 1 each each DET 3197xk84g5b 5 2 nephron nephron NOUN 3197xk84g5b 5 3 contains contain VERB 3197xk84g5b 5 4 a a DET 3197xk84g5b 5 5 series series NOUN 3197xk84g5b 5 6 of of ADP 3197xk84g5b 5 7 proximal proximal ADJ 3197xk84g5b 5 8 and and CCONJ 3197xk84g5b 5 9 distal distal ADJ 3197xk84g5b 5 10 segments segment NOUN 3197xk84g5b 5 11 comprised comprise VERB 3197xk84g5b 5 12 of of ADP 3197xk84g5b 5 13 distinct distinct ADJ 3197xk84g5b 5 14 stretches stretch NOUN 3197xk84g5b 5 15 of of ADP 3197xk84g5b 5 16 cells cell NOUN 3197xk84g5b 5 17 each each PRON 3197xk84g5b 5 18 expressing express VERB 3197xk84g5b 5 19 unique unique ADJ 3197xk84g5b 5 20 solute solute ADJ 3197xk84g5b 5 21 transporter transporter NOUN 3197xk84g5b 5 22 surface surface NOUN 3197xk84g5b 5 23 proteins protein NOUN 3197xk84g5b 5 24 . . PUNCT 3197xk84g5b 6 1 these these DET 3197xk84g5b 6 2 ion ion NOUN 3197xk84g5b 6 3 channels channel NOUN 3197xk84g5b 6 4 are be AUX 3197xk84g5b 6 5 tightly tightly ADV 3197xk84g5b 6 6 linked link VERB 3197xk84g5b 6 7 to to ADP 3197xk84g5b 6 8 specific specific ADJ 3197xk84g5b 6 9 nephron nephron NOUN 3197xk84g5b 6 10 cell cell NOUN 3197xk84g5b 6 11 identities identity NOUN 3197xk84g5b 6 12 and and CCONJ 3197xk84g5b 6 13 confer confer VERB 3197xk84g5b 6 14 explicit explicit ADJ 3197xk84g5b 6 15 metabolic metabolic NOUN 3197xk84g5b 6 16 functions function NOUN 3197xk84g5b 6 17 . . PUNCT 3197xk84g5b 7 1 to to ADP 3197xk84g5b 7 2 date date NOUN 3197xk84g5b 7 3 , , PUNCT 3197xk84g5b 7 4 the the DET 3197xk84g5b 7 5 transcriptional transcriptional NOUN 3197xk84g5b 7 6 code code NOUN 3197xk84g5b 7 7 driving drive VERB 3197xk84g5b 7 8 nephron nephron NOUN 3197xk84g5b 7 9 patterning patterning NOUN 3197xk84g5b 7 10 , , PUNCT 3197xk84g5b 7 11 epithelial epithelial ADJ 3197xk84g5b 7 12 maturation maturation NOUN 3197xk84g5b 7 13 , , PUNCT 3197xk84g5b 7 14 solute solute ADJ 3197xk84g5b 7 15 transporter transporter NOUN 3197xk84g5b 7 16 program program NOUN 3197xk84g5b 7 17 activation activation NOUN 3197xk84g5b 7 18 , , PUNCT 3197xk84g5b 7 19 and and CCONJ 3197xk84g5b 7 20 subsequent subsequent ADJ 3197xk84g5b 7 21 terminal terminal ADJ 3197xk84g5b 7 22 differentiation differentiation NOUN 3197xk84g5b 7 23 of of ADP 3197xk84g5b 7 24 specialized specialized ADJ 3197xk84g5b 7 25 nephron nephron PROPN 3197xk84g5b 7 26 segments segment NOUN 3197xk84g5b 7 27 remains remains AUX 3197xk84g5b 7 28 poorly poorly ADV 3197xk84g5b 7 29 understood understand VERB 3197xk84g5b 7 30 . . PUNCT 3197xk84g5b 8 1 the the DET 3197xk84g5b 8 2 embryonic embryonic ADJ 3197xk84g5b 8 3 zebrafish zebrafish NOUN 3197xk84g5b 8 4 provides provide VERB 3197xk84g5b 8 5 an an DET 3197xk84g5b 8 6 ideal ideal ADJ 3197xk84g5b 8 7 platform platform NOUN 3197xk84g5b 8 8 to to PART 3197xk84g5b 8 9 dissect dissect VERB 3197xk84g5b 8 10 the the DET 3197xk84g5b 8 11 genetic genetic ADJ 3197xk84g5b 8 12 cues cue NOUN 3197xk84g5b 8 13 governing govern VERB 3197xk84g5b 8 14 kidney kidney NOUN 3197xk84g5b 8 15 development development NOUN 3197xk84g5b 8 16 . . PUNCT 3197xk84g5b 9 1 this this DET 3197xk84g5b 9 2 aquatic aquatic ADJ 3197xk84g5b 9 3 vertebrate vertebrate NOUN 3197xk84g5b 9 4 possesses possess VERB 3197xk84g5b 9 5 an an DET 3197xk84g5b 9 6 architecturally architecturally ADV 3197xk84g5b 9 7 simple simple ADJ 3197xk84g5b 9 8 two two NUM 3197xk84g5b 9 9 - - PUNCT 3197xk84g5b 9 10 nephron nephron NOUN 3197xk84g5b 9 11 kidney kidney NOUN 3197xk84g5b 9 12 ( ( PUNCT 3197xk84g5b 9 13 pronephros pronephros PROPN 3197xk84g5b 9 14 ) ) PUNCT 3197xk84g5b 9 15 and and CCONJ 3197xk84g5b 9 16 a a DET 3197xk84g5b 9 17 conserved conserved ADJ 3197xk84g5b 9 18 nephron nephron NOUN 3197xk84g5b 9 19 segmentation segmentation NOUN 3197xk84g5b 9 20 pattern pattern NOUN 3197xk84g5b 9 21 coupled couple VERB 3197xk84g5b 9 22 with with ADP 3197xk84g5b 9 23 high high ADJ 3197xk84g5b 9 24 fecundity fecundity NOUN 3197xk84g5b 9 25 , , PUNCT 3197xk84g5b 9 26 ex ex PROPN 3197xk84g5b 9 27 utero utero NOUN 3197xk84g5b 9 28 development development NOUN 3197xk84g5b 9 29 , , PUNCT 3197xk84g5b 9 30 and and CCONJ 3197xk84g5b 9 31 optical optical ADJ 3197xk84g5b 9 32 transparency transparency NOUN 3197xk84g5b 9 33 for for ADP 3197xk84g5b 9 34 easy easy ADJ 3197xk84g5b 9 35 visualization visualization NOUN 3197xk84g5b 9 36 of of ADP 3197xk84g5b 9 37 organogenesis organogenesis NOUN 3197xk84g5b 9 38 . . PUNCT 3197xk84g5b 10 1 here here ADV 3197xk84g5b 10 2 , , PUNCT 3197xk84g5b 10 3 we we PRON 3197xk84g5b 10 4 demonstrate demonstrate VERB 3197xk84g5b 10 5 that that SCONJ 3197xk84g5b 10 6 employing employ VERB 3197xk84g5b 10 7 the the DET 3197xk84g5b 10 8 zebrafish zebrafish NOUN 3197xk84g5b 10 9 to to PART 3197xk84g5b 10 10 perform perform VERB 3197xk84g5b 10 11 genetic genetic ADJ 3197xk84g5b 10 12 studies study NOUN 3197xk84g5b 10 13 cultivates cultivate VERB 3197xk84g5b 10 14 the the DET 3197xk84g5b 10 15 identification identification NOUN 3197xk84g5b 10 16 of of ADP 3197xk84g5b 10 17 novel novel ADJ 3197xk84g5b 10 18 nephron nephron NOUN 3197xk84g5b 10 19 regulators regulator NOUN 3197xk84g5b 10 20 . . PUNCT 3197xk84g5b 11 1 by by ADP 3197xk84g5b 11 2 performing perform VERB 3197xk84g5b 11 3 a a DET 3197xk84g5b 11 4 forward forward ADV 3197xk84g5b 11 5 haploid haploid NOUN 3197xk84g5b 11 6 genetic genetic ADJ 3197xk84g5b 11 7 screen screen NOUN 3197xk84g5b 11 8 , , PUNCT 3197xk84g5b 11 9 we we PRON 3197xk84g5b 11 10 discovered discover VERB 3197xk84g5b 11 11 that that SCONJ 3197xk84g5b 11 12 the the DET 3197xk84g5b 11 13 transcription transcription NOUN 3197xk84g5b 11 14 factor factor NOUN 3197xk84g5b 11 15 ap-2 ap-2 SPACE 3197xk84g5b 11 16 alpha alpha NOUN 3197xk84g5b 11 17 ( ( PUNCT 3197xk84g5b 11 18 tfap2a tfap2a SPACE 3197xk84g5b 11 19 ) ) PUNCT 3197xk84g5b 11 20 directs direct VERB 3197xk84g5b 11 21 a a DET 3197xk84g5b 11 22 genetic genetic ADJ 3197xk84g5b 11 23 regulatory regulatory ADJ 3197xk84g5b 11 24 network network NOUN 3197xk84g5b 11 25 that that PRON 3197xk84g5b 11 26 promotes promote VERB 3197xk84g5b 11 27 the the DET 3197xk84g5b 11 28 terminal terminal ADJ 3197xk84g5b 11 29 differentiation differentiation NOUN 3197xk84g5b 11 30 of of ADP 3197xk84g5b 11 31 the the DET 3197xk84g5b 11 32 distal distal ADJ 3197xk84g5b 11 33 early early ADV 3197xk84g5b 11 34 / / SYM 3197xk84g5b 11 35 thick thick ADJ 3197xk84g5b 11 36 ascending ascend VERB 3197xk84g5b 11 37 limb limb NOUN 3197xk84g5b 11 38 ( ( PUNCT 3197xk84g5b 11 39 de de X 3197xk84g5b 11 40 / / SYM 3197xk84g5b 11 41 tal tal PROPN 3197xk84g5b 11 42 ) ) PUNCT 3197xk84g5b 11 43 and and CCONJ 3197xk84g5b 11 44 distal distal ADJ 3197xk84g5b 11 45 late late ADJ 3197xk84g5b 11 46 / / SYM 3197xk84g5b 11 47 distal distal ADJ 3197xk84g5b 11 48 convoluted convoluted ADJ 3197xk84g5b 11 49 tubule tubule NOUN 3197xk84g5b 11 50 ( ( PUNCT 3197xk84g5b 11 51 dl dl PROPN 3197xk84g5b 11 52 / / SYM 3197xk84g5b 11 53 dct dct PROPN 3197xk84g5b 11 54 ) ) PUNCT 3197xk84g5b 11 55 nephron nephron NOUN 3197xk84g5b 11 56 segments segment NOUN 3197xk84g5b 11 57 . . PUNCT 3197xk84g5b 12 1 tfap2a tfap2a PUNCT 3197xk84g5b 12 2 operates operate VERB 3197xk84g5b 12 3 a a DET 3197xk84g5b 12 4 circuit circuit NOUN 3197xk84g5b 12 5 consisting consist VERB 3197xk84g5b 12 6 of of ADP 3197xk84g5b 12 7 tfap2b tfap2b NUM 3197xk84g5b 12 8 and and CCONJ 3197xk84g5b 12 9 irx1a irx1a ADV 3197xk84g5b 12 10 to to PART 3197xk84g5b 12 11 activate activate VERB 3197xk84g5b 12 12 the the DET 3197xk84g5b 12 13 expression expression NOUN 3197xk84g5b 12 14 of of ADP 3197xk84g5b 12 15 distal distal ADJ 3197xk84g5b 12 16 nephron nephron PROPN 3197xk84g5b 12 17 solute solute PROPN 3197xk84g5b 12 18 transporter transporter NOUN 3197xk84g5b 12 19 genes gene NOUN 3197xk84g5b 12 20 clcnk clcnk PROPN 3197xk84g5b 12 21 , , PUNCT 3197xk84g5b 12 22 slc12a1 slc12a1 PROPN 3197xk84g5b 12 23 , , PUNCT 3197xk84g5b 12 24 kcnj1a.1 kcnj1a.1 PROPN 3197xk84g5b 12 25 , , PUNCT 3197xk84g5b 12 26 and and CCONJ 3197xk84g5b 12 27 slc12a3 slc12a3 PROPN 3197xk84g5b 12 28 . . PUNCT 3197xk84g5b 13 1 in in ADP 3197xk84g5b 13 2 a a DET 3197xk84g5b 13 3 separate separate ADJ 3197xk84g5b 13 4 study study NOUN 3197xk84g5b 13 5 , , PUNCT 3197xk84g5b 13 6 we we PRON 3197xk84g5b 13 7 reported report VERB 3197xk84g5b 13 8 for for ADP 3197xk84g5b 13 9 the the DET 3197xk84g5b 13 10 first first ADJ 3197xk84g5b 13 11 time time NOUN 3197xk84g5b 13 12 that that PRON 3197xk84g5b 13 13 kctd15 kctd15 NOUN 3197xk84g5b 13 14 paralogs paralog VERB 3197xk84g5b 13 15 , , PUNCT 3197xk84g5b 13 16 kctd15a kctd15a PROPN 3197xk84g5b 13 17 and and CCONJ 3197xk84g5b 13 18 kctd15b kctd15b NOUN 3197xk84g5b 13 19 , , PUNCT 3197xk84g5b 13 20 are be AUX 3197xk84g5b 13 21 key key ADJ 3197xk84g5b 13 22 components component NOUN 3197xk84g5b 13 23 of of ADP 3197xk84g5b 13 24 the the DET 3197xk84g5b 13 25 tfap2a tfap2a VERB 3197xk84g5b 13 26 distal distal ADJ 3197xk84g5b 13 27 nephron nephron PROPN 3197xk84g5b 13 28 network network NOUN 3197xk84g5b 13 29 . . PUNCT 3197xk84g5b 14 1 by by ADP 3197xk84g5b 14 2 employing employ VERB 3197xk84g5b 14 3 crispr crispr PROPN 3197xk84g5b 14 4 - - PUNCT 3197xk84g5b 14 5 cas9 cas9 NOUN 3197xk84g5b 14 6 and and CCONJ 3197xk84g5b 14 7 knockdown knockdown NOUN 3197xk84g5b 14 8 strategies strategy NOUN 3197xk84g5b 14 9 , , PUNCT 3197xk84g5b 14 10 we we PRON 3197xk84g5b 14 11 determined determine VERB 3197xk84g5b 14 12 kctd15a kctd15a PROPN 3197xk84g5b 14 13 / / SYM 3197xk84g5b 14 14 b b PROPN 3197xk84g5b 14 15 loss loss NOUN 3197xk84g5b 14 16 primes primes PROPN 3197xk84g5b 14 17 nephron nephron NOUN 3197xk84g5b 14 18 cells cell NOUN 3197xk84g5b 14 19 to to PART 3197xk84g5b 14 20 adopt adopt VERB 3197xk84g5b 14 21 a a DET 3197xk84g5b 14 22 de de PROPN 3197xk84g5b 14 23 / / SYM 3197xk84g5b 14 24 tal tal PROPN 3197xk84g5b 14 25 cell cell NOUN 3197xk84g5b 14 26 signature signature NOUN 3197xk84g5b 14 27 . . PUNCT 3197xk84g5b 15 1 mechanistically mechanistically ADV 3197xk84g5b 15 2 , , PUNCT 3197xk84g5b 15 3 kctd15a kctd15a PROPN 3197xk84g5b 15 4 / / SYM 3197xk84g5b 15 5 b b PROPN 3197xk84g5b 15 6 restricts restrict VERB 3197xk84g5b 15 7 de de X 3197xk84g5b 15 8 / / SYM 3197xk84g5b 15 9 tal tal NOUN 3197xk84g5b 15 10 differentiation differentiation NOUN 3197xk84g5b 15 11 by by ADP 3197xk84g5b 15 12 repressing repress VERB 3197xk84g5b 15 13 tfap2a tfap2a VERB 3197xk84g5b 15 14 activity activity NOUN 3197xk84g5b 15 15 in in ADP 3197xk84g5b 15 16 developing develop VERB 3197xk84g5b 15 17 nephrons nephron NOUN 3197xk84g5b 15 18 . . PUNCT 3197xk84g5b 16 1 further further ADJ 3197xk84g5b 16 2 interrogation interrogation NOUN 3197xk84g5b 16 3 of of ADP 3197xk84g5b 16 4 this this DET 3197xk84g5b 16 5 signaling signal VERB 3197xk84g5b 16 6 axis axis NOUN 3197xk84g5b 16 7 revealed reveal VERB 3197xk84g5b 16 8 tfap2a tfap2a PUNCT 3197xk84g5b 16 9 can can AUX 3197xk84g5b 16 10 reciprocally reciprocally ADV 3197xk84g5b 16 11 promote promote VERB 3197xk84g5b 16 12 kctd15 kctd15 NOUN 3197xk84g5b 16 13 transcription transcription NOUN 3197xk84g5b 16 14 . . PUNCT 3197xk84g5b 17 1 our our PRON 3197xk84g5b 17 2 data datum NOUN 3197xk84g5b 17 3 presents present VERB 3197xk84g5b 17 4 a a DET 3197xk84g5b 17 5 new new ADJ 3197xk84g5b 17 6 transcription transcription NOUN 3197xk84g5b 17 7 factor factor NOUN 3197xk84g5b 17 8 - - PUNCT 3197xk84g5b 17 9 repressor repressor NOUN 3197xk84g5b 17 10 feedback feedback NOUN 3197xk84g5b 17 11 module module NOUN 3197xk84g5b 17 12 where where SCONJ 3197xk84g5b 17 13 nephron nephron PROPN 3197xk84g5b 17 14 segment segment NOUN 3197xk84g5b 17 15 fate fate NOUN 3197xk84g5b 17 16 is be AUX 3197xk84g5b 17 17 controlled control VERB 3197xk84g5b 17 18 by by ADP 3197xk84g5b 17 19 precise precise ADJ 3197xk84g5b 17 20 regulation regulation NOUN 3197xk84g5b 17 21 of of ADP 3197xk84g5b 17 22 tfap2a tfap2a SPACE 3197xk84g5b 17 23 - - PUNCT 3197xk84g5b 17 24 kctd15 kctd15 NOUN 3197xk84g5b 17 25 kinetics kinetic NOUN 3197xk84g5b 17 26 . . PUNCT 3197xk84g5b 18 1 lastly lastly ADV 3197xk84g5b 18 2 , , PUNCT 3197xk84g5b 18 3 we we PRON 3197xk84g5b 18 4 identified identify VERB 3197xk84g5b 18 5 two two NUM 3197xk84g5b 18 6 discrete discrete ADJ 3197xk84g5b 18 7 roles role NOUN 3197xk84g5b 18 8 for for ADP 3197xk84g5b 18 9 the the DET 3197xk84g5b 18 10 grhl2 grhl2 ADJ 3197xk84g5b 18 11 paralogs paralog NOUN 3197xk84g5b 18 12 , , PUNCT 3197xk84g5b 18 13 grhl2a grhl2a NOUN 3197xk84g5b 18 14 and and CCONJ 3197xk84g5b 18 15 grhl2b grhl2b SPACE 3197xk84g5b 18 16 , , PUNCT 3197xk84g5b 18 17 in in ADP 3197xk84g5b 18 18 solute solute ADJ 3197xk84g5b 18 19 transporter transporter NOUN 3197xk84g5b 18 20 program program NOUN 3197xk84g5b 18 21 activation activation NOUN 3197xk84g5b 18 22 and and CCONJ 3197xk84g5b 18 23 epithelial epithelial ADJ 3197xk84g5b 18 24 maturation maturation NOUN 3197xk84g5b 18 25 during during ADP 3197xk84g5b 18 26 distal distal ADJ 3197xk84g5b 18 27 nephron nephron PROPN 3197xk84g5b 18 28 development development NOUN 3197xk84g5b 18 29 . . PUNCT 3197xk84g5b 19 1 loss loss NOUN 3197xk84g5b 19 2 of of ADP 3197xk84g5b 19 3 grhl2a grhl2a SPACE 3197xk84g5b 19 4 / / SYM 3197xk84g5b 19 5 b b ADP 3197xk84g5b 19 6 produced produce VERB 3197xk84g5b 19 7 developmental developmental ADJ 3197xk84g5b 19 8 abnormalities abnormality NOUN 3197xk84g5b 19 9 in in ADP 3197xk84g5b 19 10 both both CCONJ 3197xk84g5b 19 11 the the DET 3197xk84g5b 19 12 pronephric pronephric ADJ 3197xk84g5b 19 13 duct duct NOUN 3197xk84g5b 19 14 and and CCONJ 3197xk84g5b 19 15 otic otic ADJ 3197xk84g5b 19 16 vesicle vesicle NOUN 3197xk84g5b 19 17 . . PUNCT 3197xk84g5b 20 1 in in ADP 3197xk84g5b 20 2 addition addition NOUN 3197xk84g5b 20 3 to to ADP 3197xk84g5b 20 4 reductions reduction NOUN 3197xk84g5b 20 5 in in ADP 3197xk84g5b 20 6 clcnk clcnk PROPN 3197xk84g5b 20 7 and and CCONJ 3197xk84g5b 20 8 slc12a3 slc12a3 NOUN 3197xk84g5b 20 9 expression expression NOUN 3197xk84g5b 20 10 , , PUNCT 3197xk84g5b 20 11 grhl2a grhl2a SPACE 3197xk84g5b 20 12 / / SYM 3197xk84g5b 20 13 b b X 3197xk84g5b 20 14 - - PUNCT 3197xk84g5b 20 15 deficient deficient ADJ 3197xk84g5b 20 16 nephrons nephron NOUN 3197xk84g5b 20 17 exhibited exhibit VERB 3197xk84g5b 20 18 defects defect NOUN 3197xk84g5b 20 19 in in ADP 3197xk84g5b 20 20 cell cell NOUN 3197xk84g5b 20 21 polarity polarity NOUN 3197xk84g5b 20 22 , , PUNCT 3197xk84g5b 20 23 ciliogenesis ciliogenesis NOUN 3197xk84g5b 20 24 , , PUNCT 3197xk84g5b 20 25 and and CCONJ 3197xk84g5b 20 26 basement basement NOUN 3197xk84g5b 20 27 membrane membrane NOUN 3197xk84g5b 20 28 integrity integrity NOUN 3197xk84g5b 20 29 . . PUNCT 3197xk84g5b 21 1 significantly significantly ADV 3197xk84g5b 21 2 , , PUNCT 3197xk84g5b 21 3 grhl2a grhl2a SPACE 3197xk84g5b 21 4 / / SYM 3197xk84g5b 21 5 b b NOUN 3197xk84g5b 21 6 functions function NOUN 3197xk84g5b 21 7 as as ADP 3197xk84g5b 21 8 part part NOUN 3197xk84g5b 21 9 of of ADP 3197xk84g5b 21 10 the the DET 3197xk84g5b 21 11 tfap2 tfap2 ADJ 3197xk84g5b 21 12 genetic genetic ADJ 3197xk84g5b 21 13 network network NOUN 3197xk84g5b 21 14 and and CCONJ 3197xk84g5b 21 15 promotes promote VERB 3197xk84g5b 21 16 expression expression NOUN 3197xk84g5b 21 17 of of ADP 3197xk84g5b 21 18 tfap2b tfap2b PUNCT 3197xk84g5b 21 19 in in ADP 3197xk84g5b 21 20 the the DET 3197xk84g5b 21 21 distal distal ADJ 3197xk84g5b 21 22 nephron nephron PROPN 3197xk84g5b 21 23 . . PUNCT 3197xk84g5b 22 1 taken take VERB 3197xk84g5b 22 2 together together ADV 3197xk84g5b 22 3 , , PUNCT 3197xk84g5b 22 4 key key ADJ 3197xk84g5b 22 5 developmental developmental ADJ 3197xk84g5b 22 6 insights insight NOUN 3197xk84g5b 22 7 from from ADP 3197xk84g5b 22 8 our our PRON 3197xk84g5b 22 9 zebrafish zebrafish NOUN 3197xk84g5b 22 10 studies study NOUN 3197xk84g5b 22 11 will will AUX 3197xk84g5b 22 12 support support VERB 3197xk84g5b 22 13 the the DET 3197xk84g5b 22 14 assembly assembly NOUN 3197xk84g5b 22 15 of of ADP 3197xk84g5b 22 16 the the DET 3197xk84g5b 22 17 genetic genetic ADJ 3197xk84g5b 22 18 blueprint blueprint NOUN 3197xk84g5b 22 19 required require VERB 3197xk84g5b 22 20 to to PART 3197xk84g5b 22 21 fashion fashion VERB 3197xk84g5b 22 22 a a DET 3197xk84g5b 22 23 nephron nephron NOUN 3197xk84g5b 22 24 , , PUNCT 3197xk84g5b 22 25 and and CCONJ 3197xk84g5b 22 26 in in ADP 3197xk84g5b 22 27 turn turn NOUN 3197xk84g5b 22 28 support support VERB 3197xk84g5b 22 29 efforts effort NOUN 3197xk84g5b 22 30 to to PART 3197xk84g5b 22 31 advance advance VERB 3197xk84g5b 22 32 kidney kidney NOUN 3197xk84g5b 22 33 organoid organoid NOUN 3197xk84g5b 22 34 technology technology NOUN 3197xk84g5b 22 35 , , PUNCT 3197xk84g5b 22 36 further far ADV 3197xk84g5b 22 37 develop develop VERB 3197xk84g5b 22 38 precision precision NOUN 3197xk84g5b 22 39 medicine medicine NOUN 3197xk84g5b 22 40 , , PUNCT 3197xk84g5b 22 41 and and CCONJ 3197xk84g5b 22 42 deepen deepen VERB 3197xk84g5b 22 43 our our PRON 3197xk84g5b 22 44 understanding understanding NOUN 3197xk84g5b 22 45 of of ADP 3197xk84g5b 22 46 congenital congenital ADJ 3197xk84g5b 22 47 renal renal ADJ 3197xk84g5b 22 48 syndromes syndrome NOUN 3197xk84g5b 22 49 . . PUNCT