id sid tid token lemma pos 41687h17c2h 1 1 hydrogels hydrogel NOUN 41687h17c2h 1 2 have have AUX 41687h17c2h 1 3 proven prove VERB 41687h17c2h 1 4 to to PART 41687h17c2h 1 5 be be AUX 41687h17c2h 1 6 useful useful ADJ 41687h17c2h 1 7 materials material NOUN 41687h17c2h 1 8 for for ADP 41687h17c2h 1 9 myriad myriad ADJ 41687h17c2h 1 10 biomedical biomedical ADJ 41687h17c2h 1 11 applications application NOUN 41687h17c2h 1 12 , , PUNCT 41687h17c2h 1 13 with with ADP 41687h17c2h 1 14 the the DET 41687h17c2h 1 15 hydrated hydrated ADJ 41687h17c2h 1 16 network network NOUN 41687h17c2h 1 17 often often ADV 41687h17c2h 1 18 serving serve VERB 41687h17c2h 1 19 as as ADP 41687h17c2h 1 20 a a DET 41687h17c2h 1 21 crude crude ADJ 41687h17c2h 1 22 synthetic synthetic ADJ 41687h17c2h 1 23 extracellular extracellular ADJ 41687h17c2h 1 24 matrix matrix NOUN 41687h17c2h 1 25 capable capable ADJ 41687h17c2h 1 26 of of ADP 41687h17c2h 1 27 interfacing interface VERB 41687h17c2h 1 28 with with ADP 41687h17c2h 1 29 tissues tissue NOUN 41687h17c2h 1 30 in in ADP 41687h17c2h 1 31 the the DET 41687h17c2h 1 32 body body NOUN 41687h17c2h 1 33 . . PUNCT 41687h17c2h 2 1 supramolecular supramolecular ADJ 41687h17c2h 2 2 crosslinking crosslinking NOUN 41687h17c2h 2 3 of of ADP 41687h17c2h 2 4 these these DET 41687h17c2h 2 5 networks network NOUN 41687h17c2h 2 6 allows allow VERB 41687h17c2h 2 7 for for ADP 41687h17c2h 2 8 incorporation incorporation NOUN 41687h17c2h 2 9 of of ADP 41687h17c2h 2 10 tunable tunable ADJ 41687h17c2h 2 11 dynamics dynamic NOUN 41687h17c2h 2 12 within within ADP 41687h17c2h 2 13 the the DET 41687h17c2h 2 14 network network NOUN 41687h17c2h 2 15 backbone backbone NOUN 41687h17c2h 2 16 , , PUNCT 41687h17c2h 2 17 better well ADV 41687h17c2h 2 18 mimicking mimic VERB 41687h17c2h 2 19 the the DET 41687h17c2h 2 20 dynamic dynamic ADJ 41687h17c2h 2 21 properties property NOUN 41687h17c2h 2 22 of of ADP 41687h17c2h 2 23 natural natural ADJ 41687h17c2h 2 24 tissues tissue NOUN 41687h17c2h 2 25 . . PUNCT 41687h17c2h 3 1 specific specific ADJ 41687h17c2h 3 2 and and CCONJ 41687h17c2h 3 3 tunable tunable ADJ 41687h17c2h 3 4 interactions interaction NOUN 41687h17c2h 3 5 at at ADP 41687h17c2h 3 6 network network NOUN 41687h17c2h 3 7 crosslinks crosslink NOUN 41687h17c2h 3 8 can can AUX 41687h17c2h 3 9 be be AUX 41687h17c2h 3 10 achieved achieve VERB 41687h17c2h 3 11 by by ADP 41687h17c2h 3 12 supramolecular supramolecular ADJ 41687h17c2h 3 13 host host NOUN 41687h17c2h 3 14 - - PUNCT 41687h17c2h 3 15 guest guest NOUN 41687h17c2h 3 16 complexation complexation NOUN 41687h17c2h 3 17 . . PUNCT 41687h17c2h 4 1 in in ADP 41687h17c2h 4 2 this this DET 41687h17c2h 4 3 work work NOUN 41687h17c2h 4 4 , , PUNCT 41687h17c2h 4 5 i i PRON 41687h17c2h 4 6 have have AUX 41687h17c2h 4 7 chosen choose VERB 41687h17c2h 4 8 to to PART 41687h17c2h 4 9 focus focus VERB 41687h17c2h 4 10 on on ADP 41687h17c2h 4 11 the the DET 41687h17c2h 4 12 host host NOUN 41687h17c2h 4 13 macrocycle macrocycle NOUN 41687h17c2h 4 14 cucurbit[7]uril cucurbit[7]uril PROPN 41687h17c2h 4 15 ( ( PUNCT 41687h17c2h 4 16 cb[7 cb[7 NOUN 41687h17c2h 4 17 ] ] X 41687h17c2h 4 18 ) ) PUNCT 41687h17c2h 4 19 due due ADP 41687h17c2h 4 20 to to ADP 41687h17c2h 4 21 the the DET 41687h17c2h 4 22 wide wide ADJ 41687h17c2h 4 23 range range NOUN 41687h17c2h 4 24 and and CCONJ 41687h17c2h 4 25 exceedingly exceedingly ADV 41687h17c2h 4 26 high high ADJ 41687h17c2h 4 27 upper upper ADJ 41687h17c2h 4 28 limits limit NOUN 41687h17c2h 4 29 of of ADP 41687h17c2h 4 30 its its PRON 41687h17c2h 4 31 attainable attainable ADJ 41687h17c2h 4 32 binding bind VERB 41687h17c2h 4 33 affinities affinity NOUN 41687h17c2h 4 34 in in ADP 41687h17c2h 4 35 monovalent monovalent NOUN 41687h17c2h 4 36 binding binding NOUN 41687h17c2h 4 37 to to ADP 41687h17c2h 4 38 small small ADJ 41687h17c2h 4 39 molecule molecule NOUN 41687h17c2h 4 40 motifs motif NOUN 41687h17c2h 4 41 . . PUNCT 41687h17c2h 5 1 herein herein ADV 41687h17c2h 5 2 , , PUNCT 41687h17c2h 5 3 i i PRON 41687h17c2h 5 4 first first ADV 41687h17c2h 5 5 survey survey VERB 41687h17c2h 5 6 commonly commonly ADV 41687h17c2h 5 7 available available ADJ 41687h17c2h 5 8 host host NOUN 41687h17c2h 5 9 - - PUNCT 41687h17c2h 5 10 guest guest NOUN 41687h17c2h 5 11 systems system NOUN 41687h17c2h 5 12 and and CCONJ 41687h17c2h 5 13 review review VERB 41687h17c2h 5 14 design design NOUN 41687h17c2h 5 15 considerations consideration NOUN 41687h17c2h 5 16 of of ADP 41687h17c2h 5 17 tuning tune VERB 41687h17c2h 5 18 the the DET 41687h17c2h 5 19 complimentary complimentary ADJ 41687h17c2h 5 20 interactions interaction NOUN 41687h17c2h 5 21 underlying underlie VERB 41687h17c2h 5 22 this this DET 41687h17c2h 5 23 supramolecular supramolecular ADJ 41687h17c2h 5 24 paradigm paradigm NOUN 41687h17c2h 5 25 . . PUNCT 41687h17c2h 6 1 i i PRON 41687h17c2h 6 2 then then ADV 41687h17c2h 6 3 demonstrate demonstrate VERB 41687h17c2h 6 4 the the DET 41687h17c2h 6 5 incorporation incorporation NOUN 41687h17c2h 6 6 of of ADP 41687h17c2h 6 7 cb[7 cb[7 SPACE 41687h17c2h 6 8 ] ] X 41687h17c2h 6 9 at at ADP 41687h17c2h 6 10 the the DET 41687h17c2h 6 11 crosslinks crosslink NOUN 41687h17c2h 6 12 of of ADP 41687h17c2h 6 13 hydrogel hydrogel NOUN 41687h17c2h 6 14 networks network NOUN 41687h17c2h 6 15 , , PUNCT 41687h17c2h 6 16 and and CCONJ 41687h17c2h 6 17 subsequent subsequent ADJ 41687h17c2h 6 18 tuning tuning NOUN 41687h17c2h 6 19 of of ADP 41687h17c2h 6 20 crosslink crosslink ADJ 41687h17c2h 6 21 host host NOUN 41687h17c2h 6 22 - - PUNCT 41687h17c2h 6 23 guest guest NOUN 41687h17c2h 6 24 binding bind VERB 41687h17c2h 6 25 affinity affinity NOUN 41687h17c2h 6 26 , , PUNCT 41687h17c2h 6 27 propagates propagate VERB 41687h17c2h 6 28 across across ADP 41687h17c2h 6 29 length length NOUN 41687h17c2h 6 30 scales scale NOUN 41687h17c2h 6 31 to to PART 41687h17c2h 6 32 allow allow VERB 41687h17c2h 6 33 for for ADP 41687h17c2h 6 34 control control NOUN 41687h17c2h 6 35 of of ADP 41687h17c2h 6 36 resultant resultant ADJ 41687h17c2h 6 37 bulk bulk ADJ 41687h17c2h 6 38 material material NOUN 41687h17c2h 6 39 properties property NOUN 41687h17c2h 6 40 . . PUNCT 41687h17c2h 7 1 next next ADV 41687h17c2h 7 2 , , PUNCT 41687h17c2h 7 3 i i PRON 41687h17c2h 7 4 investigate investigate VERB 41687h17c2h 7 5 the the DET 41687h17c2h 7 6 impact impact NOUN 41687h17c2h 7 7 of of ADP 41687h17c2h 7 8 crosslink crosslink ADJ 41687h17c2h 7 9 affinity affinity NOUN 41687h17c2h 7 10 and and CCONJ 41687h17c2h 7 11 dynamics dynamic NOUN 41687h17c2h 7 12 on on ADP 41687h17c2h 7 13 diffusion diffusion NOUN 41687h17c2h 7 14 of of ADP 41687h17c2h 7 15 macromolecular macromolecular ADJ 41687h17c2h 7 16 solutes solute NOUN 41687h17c2h 7 17 within within ADP 41687h17c2h 7 18 a a DET 41687h17c2h 7 19 hydrogel hydrogel NOUN 41687h17c2h 7 20 network network NOUN 41687h17c2h 7 21 , , PUNCT 41687h17c2h 7 22 incorporating incorporate VERB 41687h17c2h 7 23 discussions discussion NOUN 41687h17c2h 7 24 on on ADP 41687h17c2h 7 25 the the DET 41687h17c2h 7 26 interplay interplay NOUN 41687h17c2h 7 27 between between ADP 41687h17c2h 7 28 mean mean ADJ 41687h17c2h 7 29 mesh mesh NOUN 41687h17c2h 7 30 size size NOUN 41687h17c2h 7 31 , , PUNCT 41687h17c2h 7 32 model model NOUN 41687h17c2h 7 33 drug drug NOUN 41687h17c2h 7 34 molecular molecular ADJ 41687h17c2h 7 35 weights weight NOUN 41687h17c2h 7 36 , , PUNCT 41687h17c2h 7 37 thermodynamics thermodynamic NOUN 41687h17c2h 7 38 of of ADP 41687h17c2h 7 39 crosslink crosslink ADJ 41687h17c2h 7 40 reorganization reorganization NOUN 41687h17c2h 7 41 , , PUNCT 41687h17c2h 7 42 optimization optimization NOUN 41687h17c2h 7 43 of of ADP 41687h17c2h 7 44 ideal ideal ADJ 41687h17c2h 7 45 networks network NOUN 41687h17c2h 7 46 , , PUNCT 41687h17c2h 7 47 and and CCONJ 41687h17c2h 7 48 deviations deviation NOUN 41687h17c2h 7 49 from from ADP 41687h17c2h 7 50 classical classical ADJ 41687h17c2h 7 51 stokes stoke NOUN 41687h17c2h 7 52 - - PUNCT 41687h17c2h 7 53 einstein einstein ADJ 41687h17c2h 7 54 predictions prediction NOUN 41687h17c2h 7 55 . . PUNCT 41687h17c2h 8 1 this this DET 41687h17c2h 8 2 work work NOUN 41687h17c2h 8 3 transitions transition NOUN 41687h17c2h 8 4 to to ADP 41687h17c2h 8 5 a a DET 41687h17c2h 8 6 critical critical ADJ 41687h17c2h 8 7 evaluation evaluation NOUN 41687h17c2h 8 8 of of ADP 41687h17c2h 8 9 the the DET 41687h17c2h 8 10 disconnect disconnect NOUN 41687h17c2h 8 11 between between ADP 41687h17c2h 8 12 in in ADP 41687h17c2h 8 13 vitro vitro X 41687h17c2h 8 14 and and CCONJ 41687h17c2h 8 15 in in ADP 41687h17c2h 8 16 vivo vivo ADJ 41687h17c2h 8 17 modeling modeling NOUN 41687h17c2h 8 18 of of ADP 41687h17c2h 8 19 drug drug NOUN 41687h17c2h 8 20 delivery delivery NOUN 41687h17c2h 8 21 by by ADP 41687h17c2h 8 22 hydrogel hydrogel NOUN 41687h17c2h 8 23 encapsulation encapsulation NOUN 41687h17c2h 8 24 . . PUNCT 41687h17c2h 9 1 my my PRON 41687h17c2h 9 2 final final ADJ 41687h17c2h 9 3 investigation investigation NOUN 41687h17c2h 9 4 of of ADP 41687h17c2h 9 5 fundamental fundamental ADJ 41687h17c2h 9 6 phenomena phenomenon NOUN 41687h17c2h 9 7 focuses focus VERB 41687h17c2h 9 8 on on ADP 41687h17c2h 9 9 effects effect NOUN 41687h17c2h 9 10 of of ADP 41687h17c2h 9 11 bulk bulk ADJ 41687h17c2h 9 12 material material NOUN 41687h17c2h 9 13 properties property NOUN 41687h17c2h 9 14 arising arise VERB 41687h17c2h 9 15 from from ADP 41687h17c2h 9 16 differences difference NOUN 41687h17c2h 9 17 in in ADP 41687h17c2h 9 18 guest guest NOUN 41687h17c2h 9 19 orientation orientation NOUN 41687h17c2h 9 20 within within ADP 41687h17c2h 9 21 crosslinks crosslink NOUN 41687h17c2h 9 22 , , PUNCT 41687h17c2h 9 23 leveraging leverage VERB 41687h17c2h 9 24 asymmetric asymmetric ADJ 41687h17c2h 9 25 guest guest NOUN 41687h17c2h 9 26 topology topology NOUN 41687h17c2h 9 27 to to PART 41687h17c2h 9 28 underscore underscore VERB 41687h17c2h 9 29 a a DET 41687h17c2h 9 30 key key ADJ 41687h17c2h 9 31 aspect aspect NOUN 41687h17c2h 9 32 of of ADP 41687h17c2h 9 33 host host NOUN 41687h17c2h 9 34 - - PUNCT 41687h17c2h 9 35 guest guest NOUN 41687h17c2h 9 36 system system NOUN 41687h17c2h 9 37 design design NOUN 41687h17c2h 9 38 considerations consideration NOUN 41687h17c2h 9 39 previously previously ADV 41687h17c2h 9 40 unaddressed unaddresse VERB 41687h17c2h 9 41 . . PUNCT 41687h17c2h 10 1 transitioning transition VERB 41687h17c2h 10 2 to to ADP 41687h17c2h 10 3 applications application NOUN 41687h17c2h 10 4 of of ADP 41687h17c2h 10 5 such such ADJ 41687h17c2h 10 6 fundamental fundamental ADJ 41687h17c2h 10 7 phenomena phenomenon NOUN 41687h17c2h 10 8 , , PUNCT 41687h17c2h 10 9 i i PRON 41687h17c2h 10 10 next next ADV 41687h17c2h 10 11 discuss discuss VERB 41687h17c2h 10 12 my my PRON 41687h17c2h 10 13 contributions contribution NOUN 41687h17c2h 10 14 to to ADP 41687h17c2h 10 15 the the DET 41687h17c2h 10 16 use use NOUN 41687h17c2h 10 17 of of ADP 41687h17c2h 10 18 cb[7]-based cb[7]-base VERB 41687h17c2h 10 19 biomaterials biomaterial NOUN 41687h17c2h 10 20 in in ADP 41687h17c2h 10 21 the the DET 41687h17c2h 10 22 targeted targeted ADJ 41687h17c2h 10 23 delivery delivery NOUN 41687h17c2h 10 24 of of ADP 41687h17c2h 10 25 chemotherapeutics chemotherapeutic NOUN 41687h17c2h 10 26 . . PUNCT 41687h17c2h 11 1 through through ADP 41687h17c2h 11 2 the the DET 41687h17c2h 11 3 pre pre NOUN 41687h17c2h 11 4 - - ADJ 41687h17c2h 11 5 targeting targeting NOUN 41687h17c2h 11 6 of of ADP 41687h17c2h 11 7 a a DET 41687h17c2h 11 8 site site NOUN 41687h17c2h 11 9 of of ADP 41687h17c2h 11 10 interest interest NOUN 41687h17c2h 11 11 in in ADP 41687h17c2h 11 12 vivo vivo NOUN 41687h17c2h 11 13 with with ADP 41687h17c2h 11 14 a a DET 41687h17c2h 11 15 cb[7]-rich cb[7]-rich ADJ 41687h17c2h 11 16 hydrogel hydrogel NOUN 41687h17c2h 11 17 , , PUNCT 41687h17c2h 11 18 delivery delivery NOUN 41687h17c2h 11 19 of of ADP 41687h17c2h 11 20 guest guest NOUN 41687h17c2h 11 21 - - PUNCT 41687h17c2h 11 22 modified modify VERB 41687h17c2h 11 23 chemotherapeutic chemotherapeutic ADJ 41687h17c2h 11 24 drugs drug NOUN 41687h17c2h 11 25 were be AUX 41687h17c2h 11 26 directed direct VERB 41687h17c2h 11 27 to to ADP 41687h17c2h 11 28 and and CCONJ 41687h17c2h 11 29 sequestered sequester VERB 41687h17c2h 11 30 at at ADP 41687h17c2h 11 31 the the DET 41687h17c2h 11 32 site site NOUN 41687h17c2h 11 33 of of ADP 41687h17c2h 11 34 interest interest NOUN 41687h17c2h 11 35 as as ADP 41687h17c2h 11 36 a a DET 41687h17c2h 11 37 function function NOUN 41687h17c2h 11 38 of of ADP 41687h17c2h 11 39 supramolecular supramolecular ADJ 41687h17c2h 11 40 host host NOUN 41687h17c2h 11 41 - - PUNCT 41687h17c2h 11 42 guest guest NOUN 41687h17c2h 11 43 affinity affinity NOUN 41687h17c2h 11 44 . . PUNCT 41687h17c2h 12 1 this this DET 41687h17c2h 12 2 drug drug NOUN 41687h17c2h 12 3 delivery delivery NOUN 41687h17c2h 12 4 platform platform NOUN 41687h17c2h 12 5 parallels parallel VERB 41687h17c2h 12 6 modern modern ADJ 41687h17c2h 12 7 advances advance NOUN 41687h17c2h 12 8 in in ADP 41687h17c2h 12 9 antibody antibody NOUN 41687h17c2h 12 10 - - PUNCT 41687h17c2h 12 11 drug drug NOUN 41687h17c2h 12 12 conjugates conjugate NOUN 41687h17c2h 12 13 ( ( PUNCT 41687h17c2h 12 14 adcs adcs PROPN 41687h17c2h 12 15 ) ) PUNCT 41687h17c2h 12 16 but but CCONJ 41687h17c2h 12 17 achieves achieve VERB 41687h17c2h 12 18 a a DET 41687h17c2h 12 19 remarkable remarkable ADJ 41687h17c2h 12 20 improvement improvement NOUN 41687h17c2h 12 21 in in ADP 41687h17c2h 12 22 drug drug NOUN 41687h17c2h 12 23 delivery delivery NOUN 41687h17c2h 12 24 efficiency efficiency NOUN 41687h17c2h 12 25 while while SCONJ 41687h17c2h 12 26 reducing reduce VERB 41687h17c2h 12 27 off off ADP 41687h17c2h 12 28 - - PUNCT 41687h17c2h 12 29 target target NOUN 41687h17c2h 12 30 effects effect NOUN 41687h17c2h 12 31 . . PUNCT 41687h17c2h 13 1 lastly lastly ADV 41687h17c2h 13 2 , , PUNCT 41687h17c2h 13 3 i i PRON 41687h17c2h 13 4 introduce introduce VERB 41687h17c2h 13 5 the the DET 41687h17c2h 13 6 selective selective ADJ 41687h17c2h 13 7 binding binding NOUN 41687h17c2h 13 8 of of ADP 41687h17c2h 13 9 fentanyl fentanyl NOUN 41687h17c2h 13 10 by by ADP 41687h17c2h 13 11 cb[7 cb[7 PROPN 41687h17c2h 13 12 ] ] PUNCT 41687h17c2h 13 13 and and CCONJ 41687h17c2h 13 14 present present VERB 41687h17c2h 13 15 a a DET 41687h17c2h 13 16 novel novel ADJ 41687h17c2h 13 17 synthesis synthesis NOUN 41687h17c2h 13 18 for for ADP 41687h17c2h 13 19 a a DET 41687h17c2h 13 20 modified modify VERB 41687h17c2h 13 21 cb[7 cb[7 NOUN 41687h17c2h 13 22 ] ] PUNCT 41687h17c2h 13 23 designed design VERB 41687h17c2h 13 24 for for ADP 41687h17c2h 13 25 decorating decorate VERB 41687h17c2h 13 26 nanoparticles nanoparticle NOUN 41687h17c2h 13 27 , , PUNCT 41687h17c2h 13 28 making make VERB 41687h17c2h 13 29 this this DET 41687h17c2h 13 30 selective selective ADJ 41687h17c2h 13 31 binding bind VERB 41687h17c2h 13 32 amenable amenable NOUN 41687h17c2h 13 33 to to ADP 41687h17c2h 13 34 quantification quantification NOUN 41687h17c2h 13 35 via via ADP 41687h17c2h 13 36 surface surface NOUN 41687h17c2h 13 37 enhanced enhance VERB 41687h17c2h 13 38 raman raman NOUN 41687h17c2h 13 39 spectroscopy spectroscopy NOUN 41687h17c2h 13 40 ( ( PUNCT 41687h17c2h 13 41 sers ser NOUN 41687h17c2h 13 42 ) ) PUNCT 41687h17c2h 13 43 , , PUNCT 41687h17c2h 13 44 in in ADP 41687h17c2h 13 45 response response NOUN 41687h17c2h 13 46 to to ADP 41687h17c2h 13 47 the the DET 41687h17c2h 13 48 current current ADJ 41687h17c2h 13 49 opioid opioid NOUN 41687h17c2h 13 50 epidemic epidemic PROPN 41687h17c2h 13 51 national national ADJ 41687h17c2h 13 52 emergency emergency NOUN 41687h17c2h 13 53 . . PUNCT