id	sid	tid	token	lemma	pos
4q77fr0099z	1	1	prostate	prostate	NOUN
4q77fr0099z	1	2	cancer	cancer	NOUN
4q77fr0099z	1	3	(	(	PUNCT
4q77fr0099z	1	4	pca	pca	PROPN
4q77fr0099z	1	5	)	)	PUNCT
4q77fr0099z	1	6	has	have	VERB
4q77fr0099z	1	7	the	the	DET
4q77fr0099z	1	8	second	second	ADJ
4q77fr0099z	1	9	highest	high	ADJ
4q77fr0099z	1	10	incidence	incidence	NOUN
4q77fr0099z	1	11	of	of	ADP
4q77fr0099z	1	12	all	all	DET
4q77fr0099z	1	13	malignancies	malignancy	NOUN
4q77fr0099z	1	14	in	in	ADP
4q77fr0099z	1	15	men	man	NOUN
4q77fr0099z	1	16	worldwide	worldwide	ADV
4q77fr0099z	1	17	.	.	PUNCT
4q77fr0099z	2	1	advanced	advanced	ADJ
4q77fr0099z	2	2	pca	pca	PROPN
4q77fr0099z	2	3	shows	show	VERB
4q77fr0099z	2	4	overwhelming	overwhelming	ADJ
4q77fr0099z	2	5	de	de	X
4q77fr0099z	2	6	novo	novo	NOUN
4q77fr0099z	2	7	resistance	resistance	NOUN
4q77fr0099z	2	8	to	to	ADP
4q77fr0099z	2	9	immunotherapy	immunotherapy	NOUN
4q77fr0099z	2	10	which	which	PRON
4q77fr0099z	2	11	has	have	AUX
4q77fr0099z	2	12	revolutionized	revolutionize	VERB
4q77fr0099z	2	13	cancer	cancer	NOUN
4q77fr0099z	2	14	treatment	treatment	NOUN
4q77fr0099z	2	15	and	and	CCONJ
4q77fr0099z	2	16	achieved	achieve	VERB
4q77fr0099z	2	17	remarkable	remarkable	ADJ
4q77fr0099z	2	18	success	success	NOUN
4q77fr0099z	2	19	across	across	ADP
4q77fr0099z	2	20	many	many	ADJ
4q77fr0099z	2	21	cancer	cancer	NOUN
4q77fr0099z	2	22	types	type	NOUN
4q77fr0099z	2	23	.	.	PUNCT
4q77fr0099z	3	1	to	to	PART
4q77fr0099z	3	2	combat	combat	VERB
4q77fr0099z	3	3	the	the	DET
4q77fr0099z	3	4	resistance	resistance	NOUN
4q77fr0099z	3	5	of	of	ADP
4q77fr0099z	3	6	pca	pca	PROPN
4q77fr0099z	3	7	to	to	ADP
4q77fr0099z	3	8	immunotherapy	immunotherapy	NOUN
4q77fr0099z	3	9	,	,	PUNCT
4q77fr0099z	3	10	therapeutic	therapeutic	ADJ
4q77fr0099z	3	11	efforts	effort	NOUN
4q77fr0099z	3	12	using	use	VERB
4q77fr0099z	3	13	targeted	target	VERB
4q77fr0099z	3	14	agents	agent	NOUN
4q77fr0099z	3	15	to	to	PART
4q77fr0099z	3	16	convert	convert	VERB
4q77fr0099z	3	17	"	"	PUNCT
4q77fr0099z	3	18	cold	cold	ADJ
4q77fr0099z	3	19	"	"	PUNCT
4q77fr0099z	3	20	to	to	ADP
4q77fr0099z	3	21	"	"	PUNCT
4q77fr0099z	3	22	hot	hot	ADJ
4q77fr0099z	3	23	"	"	PUNCT
4q77fr0099z	3	24	tumor	tumor	NOUN
4q77fr0099z	3	25	microenvironment	microenvironment	NOUN
4q77fr0099z	3	26	(	(	PUNCT
4q77fr0099z	3	27	tme	tme	PROPN
4q77fr0099z	3	28	)	)	PUNCT
4q77fr0099z	3	29	are	be	AUX
4q77fr0099z	3	30	promising	promise	VERB
4q77fr0099z	3	31	approaches	approach	NOUN
4q77fr0099z	3	32	that	that	PRON
4q77fr0099z	3	33	are	be	AUX
4q77fr0099z	3	34	currently	currently	ADV
4q77fr0099z	3	35	lacking	lack	VERB
4q77fr0099z	3	36	in	in	ADP
4q77fr0099z	3	37	pca	pca	PROPN
4q77fr0099z	3	38	.	.	PUNCT
4q77fr0099z	4	1	the	the	DET
4q77fr0099z	4	2	tme	tme	PROPN
4q77fr0099z	4	3	can	can	AUX
4q77fr0099z	4	4	be	be	AUX
4q77fr0099z	4	5	shaped	shape	VERB
4q77fr0099z	4	6	by	by	ADP
4q77fr0099z	4	7	both	both	DET
4q77fr0099z	4	8	cancer	cancer	NOUN
4q77fr0099z	4	9	cell	cell	NOUN
4q77fr0099z	4	10	-	-	PUNCT
4q77fr0099z	4	11	intrinsic	intrinsic	ADJ
4q77fr0099z	4	12	and	and	CCONJ
4q77fr0099z	4	13	extrinsic	extrinsic	ADJ
4q77fr0099z	4	14	mechanisms	mechanism	NOUN
4q77fr0099z	4	15	.	.	PUNCT
4q77fr0099z	5	1	because	because	SCONJ
4q77fr0099z	5	2	malignancies	malignancy	NOUN
4q77fr0099z	5	3	originate	originate	VERB
4q77fr0099z	5	4	from	from	ADP
4q77fr0099z	5	5	genetic	genetic	ADJ
4q77fr0099z	5	6	mutations	mutation	NOUN
4q77fr0099z	5	7	,	,	PUNCT
4q77fr0099z	5	8	the	the	DET
4q77fr0099z	5	9	mechanisms	mechanism	NOUN
4q77fr0099z	5	10	dysregulating	dysregulate	VERB
4q77fr0099z	5	11	the	the	DET
4q77fr0099z	5	12	immune	immune	ADJ
4q77fr0099z	5	13	landscape	landscape	NOUN
4q77fr0099z	5	14	in	in	ADP
4q77fr0099z	5	15	solid	solid	ADJ
4q77fr0099z	5	16	tumors	tumor	NOUN
4q77fr0099z	5	17	(	(	PUNCT
4q77fr0099z	5	18	pca	pca	PROPN
4q77fr0099z	5	19	included	include	VERB
4q77fr0099z	5	20	)	)	PUNCT
4q77fr0099z	5	21	can	can	AUX
4q77fr0099z	5	22	be	be	AUX
4q77fr0099z	5	23	traced	trace	VERB
4q77fr0099z	5	24	back	back	ADV
4q77fr0099z	5	25	to	to	ADP
4q77fr0099z	5	26	cancer	cancer	NOUN
4q77fr0099z	5	27	-	-	PUNCT
4q77fr0099z	5	28	cell	cell	NOUN
4q77fr0099z	5	29	-	-	PUNCT
4q77fr0099z	5	30	intrinsic	intrinsic	ADJ
4q77fr0099z	5	31	.	.	PUNCT
4q77fr0099z	6	1	however	however	ADV
4q77fr0099z	6	2	,	,	PUNCT
4q77fr0099z	6	3	how	how	SCONJ
4q77fr0099z	6	4	genetic	genetic	ADJ
4q77fr0099z	6	5	mutations	mutation	NOUN
4q77fr0099z	6	6	affect	affect	VERB
4q77fr0099z	6	7	tme	tme	NOUN
4q77fr0099z	6	8	and	and	CCONJ
4q77fr0099z	6	9	immunotherapy	immunotherapy	NOUN
4q77fr0099z	6	10	is	be	AUX
4q77fr0099z	6	11	poorly	poorly	ADV
4q77fr0099z	6	12	understood	understand	VERB
4q77fr0099z	6	13	.	.	PUNCT
4q77fr0099z	7	1	here	here	ADV
4q77fr0099z	7	2	,	,	PUNCT
4q77fr0099z	7	3	we	we	PRON
4q77fr0099z	7	4	(	(	PUNCT
4q77fr0099z	7	5	1	1	X
4q77fr0099z	7	6	)	)	PUNCT
4q77fr0099z	7	7	discovered	discover	VERB
4q77fr0099z	7	8	chromatin	chromatin	NOUN
4q77fr0099z	7	9	effector	effector	NOUN
4q77fr0099z	7	10	pygo2	pygo2	PROPN
4q77fr0099z	7	11	,	,	PUNCT
4q77fr0099z	7	12	as	as	ADP
4q77fr0099z	7	13	a	a	DET
4q77fr0099z	7	14	driver	driver	NOUN
4q77fr0099z	7	15	of	of	ADP
4q77fr0099z	7	16	pca	pca	PROPN
4q77fr0099z	7	17	and	and	CCONJ
4q77fr0099z	7	18	have	have	VERB
4q77fr0099z	7	19	a	a	DET
4q77fr0099z	7	20	significant	significant	ADJ
4q77fr0099z	7	21	amplification	amplification	NOUN
4q77fr0099z	7	22	in	in	ADP
4q77fr0099z	7	23	pca	pca	PROPN
4q77fr0099z	7	24	patients	patient	NOUN
4q77fr0099z	7	25	,	,	PUNCT
4q77fr0099z	7	26	induced	induce	VERB
4q77fr0099z	7	27	the	the	DET
4q77fr0099z	7	28	de	de	X
4q77fr0099z	7	29	novo	novo	PROPN
4q77fr0099z	7	30	resistance	resistance	NOUN
4q77fr0099z	7	31	to	to	ADP
4q77fr0099z	7	32	immunotherapy	immunotherapy	NOUN
4q77fr0099z	7	33	through	through	ADP
4q77fr0099z	7	34	suppressing	suppress	VERB
4q77fr0099z	7	35	cytotoxic	cytotoxic	ADJ
4q77fr0099z	7	36	t	t	NOUN
4q77fr0099z	7	37	lymphocytes	lymphocyte	NOUN
4q77fr0099z	7	38	(	(	PUNCT
4q77fr0099z	7	39	ctls	ctls	PROPN
4q77fr0099z	7	40	)	)	PUNCT
4q77fr0099z	7	41	infiltration	infiltration	NOUN
4q77fr0099z	7	42	in	in	ADP
4q77fr0099z	7	43	the	the	DET
4q77fr0099z	7	44	tumor	tumor	NOUN
4q77fr0099z	7	45	area	area	NOUN
4q77fr0099z	7	46	,	,	PUNCT
4q77fr0099z	7	47	and	and	CCONJ
4q77fr0099z	7	48	(	(	PUNCT
4q77fr0099z	7	49	2	2	X
4q77fr0099z	7	50	)	)	PUNCT
4q77fr0099z	7	51	uncovered	uncover	VERB
4q77fr0099z	7	52	speckle	speckle	NOUN
4q77fr0099z	7	53	-	-	PUNCT
4q77fr0099z	7	54	type	type	NOUN
4q77fr0099z	7	55	poz	poz	ADJ
4q77fr0099z	7	56	protein	protein	NOUN
4q77fr0099z	7	57	(	(	PUNCT
4q77fr0099z	7	58	spop	spop	NOUN
4q77fr0099z	7	59	)	)	PUNCT
4q77fr0099z	7	60	and	and	CCONJ
4q77fr0099z	7	61	chromodomain	chromodomain	PROPN
4q77fr0099z	7	62	helicase	helicase	PROPN
4q77fr0099z	7	63	dna	dna	PROPN
4q77fr0099z	7	64	-	-	PUNCT
4q77fr0099z	7	65	binding	bind	VERB
4q77fr0099z	7	66	protein	protein	NOUN
4q77fr0099z	7	67	1(chd1	1(chd1	NUM
4q77fr0099z	7	68	)	)	PUNCT
4q77fr0099z	7	69	which	which	PRON
4q77fr0099z	7	70	frequently	frequently	ADV
4q77fr0099z	7	71	mutated	mutate	VERB
4q77fr0099z	7	72	and	and	CCONJ
4q77fr0099z	7	73	deleted	delete	VERB
4q77fr0099z	7	74	respectively	respectively	ADV
4q77fr0099z	7	75	in	in	ADP
4q77fr0099z	7	76	pca	pca	PROPN
4q77fr0099z	7	77	synergistically	synergistically	ADV
4q77fr0099z	7	78	protected	protect	VERB
4q77fr0099z	7	79	prostate	prostate	ADJ
4q77fr0099z	7	80	epithelial	epithelial	ADJ
4q77fr0099z	7	81	cells	cell	NOUN
4q77fr0099z	7	82	from	from	ADP
4q77fr0099z	7	83	dna	dna	PROPN
4q77fr0099z	7	84	damage	damage	NOUN
4q77fr0099z	7	85	and	and	CCONJ
4q77fr0099z	7	86	implied	imply	VERB
4q77fr0099z	7	87	that	that	SCONJ
4q77fr0099z	7	88	the	the	DET
4q77fr0099z	7	89	pca	pca	PROPN
4q77fr0099z	7	90	patients	patient	NOUN
4q77fr0099z	7	91	with	with	ADP
4q77fr0099z	7	92	spop	spop	NOUN
4q77fr0099z	7	93	mutation	mutation	NOUN
4q77fr0099z	7	94	and	and	CCONJ
4q77fr0099z	7	95	chd1	chd1	ADJ
4q77fr0099z	7	96	deletion	deletion	NOUN
4q77fr0099z	7	97	might	might	AUX
4q77fr0099z	7	98	be	be	AUX
4q77fr0099z	7	99	susceptible	susceptible	ADJ
4q77fr0099z	7	100	to	to	ADP
4q77fr0099z	7	101	poly(adp	poly(adp	PROPN
4q77fr0099z	7	102	-	-	PUNCT
4q77fr0099z	7	103	ribose	ribose	NOUN
4q77fr0099z	7	104	)	)	PUNCT
4q77fr0099z	7	105	polymerase	polymerase	NOUN
4q77fr0099z	7	106	inhibitors(parpi	inhibitors(parpi	PROPN
4q77fr0099z	7	107	)	)	PUNCT
4q77fr0099z	7	108	or	or	CCONJ
4q77fr0099z	7	109	dna	dna	PROPN
4q77fr0099z	7	110	-	-	PUNCT
4q77fr0099z	7	111	damaging	damage	VERB
4q77fr0099z	7	112	agents	agent	NOUN
4q77fr0099z	7	113	and	and	CCONJ
4q77fr0099z	7	114	immunotherapy	immunotherapy	NOUN
4q77fr0099z	7	115	because	because	SCONJ
4q77fr0099z	7	116	of	of	ADP
4q77fr0099z	7	117	the	the	DET
4q77fr0099z	7	118	potential	potential	ADJ
4q77fr0099z	7	119	higher	high	ADJ
4q77fr0099z	7	120	neoantigen	neoantigen	NOUN
4q77fr0099z	7	121	expression.although	expression.although	PROPN
4q77fr0099z	7	122	pygo2	pygo2	NOUN
4q77fr0099z	7	123	was	be	AUX
4q77fr0099z	7	124	identified	identify	VERB
4q77fr0099z	7	125	as	as	ADP
4q77fr0099z	7	126	the	the	DET
4q77fr0099z	7	127	driver	driver	NOUN
4q77fr0099z	7	128	for	for	ADP
4q77fr0099z	7	129	the	the	DET
4q77fr0099z	7	130	amplicon	amplicon	NOUN
4q77fr0099z	7	131	1q21.3	1q21.3	NUM
4q77fr0099z	7	132	in	in	ADP
4q77fr0099z	7	133	pca	pca	PROPN
4q77fr0099z	7	134	,	,	PUNCT
4q77fr0099z	7	135	it	it	PRON
4q77fr0099z	7	136	remains	remain	VERB
4q77fr0099z	7	137	unclear	unclear	ADJ
4q77fr0099z	7	138	whether	whether	SCONJ
4q77fr0099z	7	139	pygo2	pygo2	PROPN
4q77fr0099z	7	140	's	's	PART
4q77fr0099z	7	141	role	role	NOUN
4q77fr0099z	7	142	in	in	ADP
4q77fr0099z	7	143	pca	pca	PROPN
4q77fr0099z	7	144	involves	involve	VERB
4q77fr0099z	7	145	the	the	DET
4q77fr0099z	7	146	regulation	regulation	NOUN
4q77fr0099z	7	147	of	of	ADP
4q77fr0099z	7	148	the	the	DET
4q77fr0099z	7	149	tme	tme	PROPN
4q77fr0099z	7	150	.	.	PUNCT
4q77fr0099z	8	1	here	here	ADV
4q77fr0099z	8	2	,	,	PUNCT
4q77fr0099z	8	3	we	we	PRON
4q77fr0099z	8	4	identified	identify	VERB
4q77fr0099z	8	5	a	a	DET
4q77fr0099z	8	6	novel	novel	NOUN
4q77fr0099z	8	7	mechanism	mechanism	NOUN
4q77fr0099z	8	8	where	where	SCONJ
4q77fr0099z	8	9	pygo2	pygo2	PROPN
4q77fr0099z	8	10	orchestrates	orchestrate	VERB
4q77fr0099z	8	11	a	a	DET
4q77fr0099z	8	12	p53	p53	NOUN
4q77fr0099z	8	13	/	/	SYM
4q77fr0099z	8	14	sp1	sp1	NOUN
4q77fr0099z	8	15	/	/	SYM
4q77fr0099z	8	16	kit	kit	PROPN
4q77fr0099z	8	17	/	/	SYM
4q77fr0099z	8	18	ido1	ido1	NOUN
4q77fr0099z	8	19	signaling	signal	VERB
4q77fr0099z	8	20	network	network	NOUN
4q77fr0099z	8	21	to	to	PART
4q77fr0099z	8	22	restrict	restrict	VERB
4q77fr0099z	8	23	ctls	ctls	NOUN
4q77fr0099z	8	24	and	and	CCONJ
4q77fr0099z	8	25	augment	augment	VERB
4q77fr0099z	8	26	regulatory	regulatory	ADJ
4q77fr0099z	8	27	t	t	NOUN
4q77fr0099z	8	28	cells	cell	NOUN
4q77fr0099z	8	29	in	in	ADP
4q77fr0099z	8	30	prostate	prostate	NOUN
4q77fr0099z	8	31	tumors	tumor	NOUN
4q77fr0099z	8	32	.	.	PUNCT
4q77fr0099z	9	1	importantly	importantly	ADV
4q77fr0099z	9	2	,	,	PUNCT
4q77fr0099z	9	3	genetic	genetic	ADJ
4q77fr0099z	9	4	ablation	ablation	NOUN
4q77fr0099z	9	5	of	of	ADP
4q77fr0099z	9	6	pygo2	pygo2	NOUN
4q77fr0099z	9	7	or	or	CCONJ
4q77fr0099z	9	8	small	small	ADJ
4q77fr0099z	9	9	-	-	PUNCT
4q77fr0099z	9	10	molecule	molecule	NOUN
4q77fr0099z	9	11	inhibitors	inhibitor	NOUN
4q77fr0099z	9	12	(	(	PUNCT
4q77fr0099z	9	13	jbc117	jbc117	PROPN
4q77fr0099z	9	14	,	,	PUNCT
4q77fr0099z	9	15	jbc117ana	jbc117ana	PROPN
4q77fr0099z	9	16	)	)	PUNCT
4q77fr0099z	9	17	targeting	target	VERB
4q77fr0099z	9	18	the	the	DET
4q77fr0099z	9	19	binding	binding	NOUN
4q77fr0099z	9	20	between	between	ADP
4q77fr0099z	9	21	pygo2	pygo2	NOUN
4q77fr0099z	9	22	and	and	CCONJ
4q77fr0099z	9	23	histone	histone	NOUN
4q77fr0099z	9	24	h3k4me2/3	h3k4me2/3	PROPN
4q77fr0099z	9	25	significantly	significantly	ADV
4q77fr0099z	9	26	enhanced	enhance	VERB
4q77fr0099z	9	27	the	the	DET
4q77fr0099z	9	28	antitumor	antitumor	PROPN
4q77fr0099z	9	29	efficacy	efficacy	NOUN
4q77fr0099z	9	30	of	of	ADP
4q77fr0099z	9	31	several	several	ADJ
4q77fr0099z	9	32	modalities	modality	NOUN
4q77fr0099z	9	33	of	of	ADP
4q77fr0099z	9	34	immunotherapeutics	immunotherapeutic	NOUN
4q77fr0099z	9	35	,	,	PUNCT
4q77fr0099z	9	36	including	include	VERB
4q77fr0099z	9	37	icb	icb	PROPN
4q77fr0099z	9	38	(	(	PUNCT
4q77fr0099z	9	39	anti	anti	ADJ
4q77fr0099z	9	40	-	-	NOUN
4q77fr0099z	9	41	pd1	pd1	NOUN
4q77fr0099z	9	42	/	/	SYM
4q77fr0099z	9	43	anti	anti	ADJ
4q77fr0099z	9	44	-	-	ADJ
4q77fr0099z	9	45	ctla4	ctla4	ADJ
4q77fr0099z	9	46	)	)	PUNCT
4q77fr0099z	9	47	,	,	PUNCT
4q77fr0099z	9	48	adoptive	adoptive	PROPN
4q77fr0099z	9	49	t	t	PROPN
4q77fr0099z	9	50	cell	cell	NOUN
4q77fr0099z	9	51	transfer	transfer	NOUN
4q77fr0099z	9	52	,	,	PUNCT
4q77fr0099z	9	53	and	and	CCONJ
4q77fr0099z	9	54	cxcr1/2	cxcr1/2	ADJ
4q77fr0099z	9	55	inhibitor	inhibitor	NOUN
4q77fr0099z	9	56	that	that	PRON
4q77fr0099z	9	57	blocks	block	VERB
4q77fr0099z	9	58	polymorphonuclear	polymorphonuclear	ADJ
4q77fr0099z	9	59	myeloid	myeloid	NOUN
4q77fr0099z	9	60	-	-	PUNCT
4q77fr0099z	9	61	derived	derive	VERB
4q77fr0099z	9	62	suppressor	suppressor	NOUN
4q77fr0099z	9	63	cells	cell	NOUN
4q77fr0099z	9	64	(	(	PUNCT
4q77fr0099z	9	65	pmn	pmn	PROPN
4q77fr0099z	9	66	-	-	PUNCT
4q77fr0099z	9	67	mdscs	mdsc	NOUN
4q77fr0099z	9	68	)	)	PUNCT
4q77fr0099z	9	69	.	.	PUNCT
4q77fr0099z	10	1	strikingly	strikingly	ADV
4q77fr0099z	10	2	,	,	PUNCT
4q77fr0099z	10	3	pygo2	pygo2	ADJ
4q77fr0099z	10	4	-	-	PUNCT
4q77fr0099z	10	5	knockout	knockout	PROPN
4q77fr0099z	10	6	and	and	CCONJ
4q77fr0099z	10	7	icb	icb	CCONJ
4q77fr0099z	10	8	combination	combination	NOUN
4q77fr0099z	10	9	led	lead	VERB
4q77fr0099z	10	10	to	to	ADP
4q77fr0099z	10	11	a	a	DET
4q77fr0099z	10	12	100	100	NUM
4q77fr0099z	10	13	%	%	NOUN
4q77fr0099z	10	14	cure	cure	NOUN
4q77fr0099z	10	15	of	of	ADP
4q77fr0099z	10	16	the	the	DET
4q77fr0099z	10	17	rm9	rm9	NOUN
4q77fr0099z	10	18	murine	murine	NOUN
4q77fr0099z	10	19	prostate	prostate	NOUN
4q77fr0099z	10	20	.	.	PUNCT
4q77fr0099z	11	1	clinically	clinically	ADV
4q77fr0099z	11	2	,	,	PUNCT
4q77fr0099z	11	3	pygo2	pygo2	NOUN
4q77fr0099z	11	4	expression	expression	NOUN
4q77fr0099z	11	5	was	be	AUX
4q77fr0099z	11	6	inversely	inversely	ADV
4q77fr0099z	11	7	correlated	correlate	VERB
4q77fr0099z	11	8	with	with	ADP
4q77fr0099z	11	9	ctl	ctl	PROPN
4q77fr0099z	11	10	gene	gene	NOUN
4q77fr0099z	11	11	signatures	signature	NOUN
4q77fr0099z	11	12	and	and	CCONJ
4q77fr0099z	11	13	cd8	cd8	PROPN
4q77fr0099z	11	14	+	+	PROPN
4q77fr0099z	11	15	t	t	PROPN
4q77fr0099z	11	16	cell	cell	NOUN
4q77fr0099z	11	17	infiltration	infiltration	NOUN
4q77fr0099z	11	18	in	in	ADP
4q77fr0099z	11	19	prostate	prostate	NOUN
4q77fr0099z	11	20	cancer	cancer	NOUN
4q77fr0099z	11	21	.	.	PUNCT
4q77fr0099z	12	1	because	because	SCONJ
4q77fr0099z	12	2	pygo2	pygo2	NOUN
4q77fr0099z	12	3	is	be	AUX
4q77fr0099z	12	4	highly	highly	ADV
4q77fr0099z	12	5	expressed	express	VERB
4q77fr0099z	12	6	in	in	ADP
4q77fr0099z	12	7	several	several	ADJ
4q77fr0099z	12	8	other	other	ADJ
4q77fr0099z	12	9	solid	solid	ADJ
4q77fr0099z	12	10	malignancies	malignancy	NOUN
4q77fr0099z	12	11	,	,	PUNCT
4q77fr0099z	12	12	therapeutic	therapeutic	ADJ
4q77fr0099z	12	13	targeting	targeting	NOUN
4q77fr0099z	12	14	of	of	ADP
4q77fr0099z	12	15	pygo2	pygo2	NOUN
4q77fr0099z	12	16	may	may	AUX
4q77fr0099z	12	17	have	have	VERB
4q77fr0099z	12	18	broad	broad	ADJ
4q77fr0099z	12	19	applications	application	NOUN
4q77fr0099z	12	20	as	as	ADP
4q77fr0099z	12	21	monotherapy	monotherapy	NOUN
4q77fr0099z	12	22	or	or	CCONJ
4q77fr0099z	12	23	immunotherapy	immunotherapy	NOUN
4q77fr0099z	12	24	sensitizer	sensitizer	ADJ
4q77fr0099z	12	25	for	for	ADP
4q77fr0099z	12	26	the	the	DET
4q77fr0099z	12	27	improved	improved	ADJ
4q77fr0099z	12	28	outcome	outcome	NOUN
4q77fr0099z	12	29	of	of	ADP
4q77fr0099z	12	30	cancer	cancer	NOUN
4q77fr0099z	12	31	patients	patient	NOUN
4q77fr0099z	12	32	.	.	PUNCT
4q77fr0099z	13	1	spop	spop	NOUN
4q77fr0099z	13	2	mutations	mutation	NOUN
4q77fr0099z	13	3	are	be	AUX
4q77fr0099z	13	4	highly	highly	ADV
4q77fr0099z	13	5	associated	associate	VERB
4q77fr0099z	13	6	with	with	ADP
4q77fr0099z	13	7	chd1	chd1	PROPN
4q77fr0099z	13	8	deletion	deletion	NOUN
4q77fr0099z	13	9	,	,	PUNCT
4q77fr0099z	13	10	defining	define	VERB
4q77fr0099z	13	11	a	a	DET
4q77fr0099z	13	12	new	new	ADJ
4q77fr0099z	13	13	subtype	subtype	NOUN
4q77fr0099z	13	14	of	of	ADP
4q77fr0099z	13	15	pca	pca	PROPN
4q77fr0099z	13	16	associated	associate	VERB
4q77fr0099z	13	17	with	with	ADP
4q77fr0099z	13	18	increased	increase	VERB
4q77fr0099z	13	19	genomic	genomic	ADJ
4q77fr0099z	13	20	instability	instability	NOUN
4q77fr0099z	13	21	.	.	PUNCT
4q77fr0099z	14	1	prostate	prostate	NOUN
4q77fr0099z	14	2	-	-	PUNCT
4q77fr0099z	14	3	specific	specific	ADJ
4q77fr0099z	14	4	single	single	ADJ
4q77fr0099z	14	5	or	or	CCONJ
4q77fr0099z	14	6	double	double	ADJ
4q77fr0099z	14	7	knockout	knockout	NOUN
4q77fr0099z	14	8	of	of	ADP
4q77fr0099z	14	9	spop	spop	NOUN
4q77fr0099z	14	10	and	and	CCONJ
4q77fr0099z	14	11	chd1	chd1	PROPN
4q77fr0099z	14	12	mice	mouse	NOUN
4q77fr0099z	14	13	failed	fail	VERB
4q77fr0099z	14	14	to	to	PART
4q77fr0099z	14	15	generate	generate	VERB
4q77fr0099z	14	16	prostate	prostate	NOUN
4q77fr0099z	14	17	adenocarcinoma	adenocarcinoma	NOUN
4q77fr0099z	14	18	.	.	PUNCT
4q77fr0099z	15	1	compared	compare	VERB
4q77fr0099z	15	2	with	with	ADP
4q77fr0099z	15	3	wild	wild	ADJ
4q77fr0099z	15	4	-	-	PUNCT
4q77fr0099z	15	5	type	type	NOUN
4q77fr0099z	15	6	or	or	CCONJ
4q77fr0099z	15	7	single	single	ADJ
4q77fr0099z	15	8	knockout	knockout	NOUN
4q77fr0099z	15	9	mice	mouse	NOUN
4q77fr0099z	15	10	,	,	PUNCT
4q77fr0099z	15	11	the	the	DET
4q77fr0099z	15	12	double	double	ADJ
4q77fr0099z	15	13	knockout	knockout	NOUN
4q77fr0099z	15	14	prostate	prostate	NOUN
4q77fr0099z	15	15	harbored	harbor	VERB
4q77fr0099z	15	16	moderately	moderately	ADV
4q77fr0099z	15	17	higher	high	ADJ
4q77fr0099z	15	18	proliferating	proliferate	VERB
4q77fr0099z	15	19	cells	cell	NOUN
4q77fr0099z	15	20	and	and	CCONJ
4q77fr0099z	15	21	dramatically	dramatically	ADV
4q77fr0099z	15	22	augmented	augment	VERB
4q77fr0099z	15	23	levels	level	NOUN
4q77fr0099z	15	24	of	of	ADP
4q77fr0099z	15	25	γh2ax	γh2ax	ADJ
4q77fr0099z	15	26	staining	stain	VERB
4q77fr0099z	15	27	.	.	PUNCT
4q77fr0099z	16	1	spop	spop	NOUN
4q77fr0099z	16	2	mutant	mutant	ADJ
4q77fr0099z	16	3	overexpression	overexpression	NOUN
4q77fr0099z	16	4	and	and	CCONJ
4q77fr0099z	16	5	chd1	chd1	NOUN
4q77fr0099z	16	6	silencing	silencing	NOUN
4q77fr0099z	16	7	synergistically	synergistically	ADV
4q77fr0099z	16	8	sensitized	sensitize	VERB
4q77fr0099z	16	9	bph1	bph1	NOUN
4q77fr0099z	16	10	to	to	ADP
4q77fr0099z	16	11	dna	dna	NOUN
4q77fr0099z	16	12	damage	damage	NOUN
4q77fr0099z	16	13	by	by	ADP
4q77fr0099z	16	14	camptothecin	camptothecin	PROPN
4q77fr0099z	16	15	.	.	PUNCT
4q77fr0099z	17	1	our	our	PRON
4q77fr0099z	17	2	results	result	NOUN
4q77fr0099z	17	3	indicated	indicate	VERB
4q77fr0099z	17	4	that	that	SCONJ
4q77fr0099z	17	5	spop	spop	NOUN
4q77fr0099z	17	6	and	and	CCONJ
4q77fr0099z	17	7	chd1	chd1	PROPN
4q77fr0099z	17	8	could	could	AUX
4q77fr0099z	17	9	synergistically	synergistically	ADV
4q77fr0099z	17	10	promote	promote	VERB
4q77fr0099z	17	11	the	the	DET
4q77fr0099z	17	12	repair	repair	NOUN
4q77fr0099z	17	13	of	of	ADP
4q77fr0099z	17	14	dna	dna	NOUN
4q77fr0099z	17	15	damage	damage	NOUN
4q77fr0099z	17	16	in	in	ADP
4q77fr0099z	17	17	prostate	prostate	ADJ
4q77fr0099z	17	18	epithelial	epithelial	ADJ
4q77fr0099z	17	19	cells	cell	NOUN
4q77fr0099z	17	20	.	.	PUNCT
4q77fr0099z	18	1	it	it	PRON
4q77fr0099z	18	2	implied	imply	VERB
4q77fr0099z	18	3	that	that	SCONJ
4q77fr0099z	18	4	this	this	DET
4q77fr0099z	18	5	subtype	subtype	NOUN
4q77fr0099z	18	6	patient	patient	NOUN
4q77fr0099z	18	7	might	might	AUX
4q77fr0099z	18	8	be	be	AUX
4q77fr0099z	18	9	sensitive	sensitive	ADJ
4q77fr0099z	18	10	to	to	ADP
4q77fr0099z	18	11	parpi	parpi	NOUN
4q77fr0099z	18	12	and	and	CCONJ
4q77fr0099z	18	13	immunotherapy	immunotherapy	NOUN
4q77fr0099z	18	14	.	.	PUNCT