id sid tid token lemma pos 5m60qr48p6n 1 1 anitibiotic anitibiotic ADJ 5m60qr48p6n 1 2 resistance resistance NOUN 5m60qr48p6n 1 3 is be AUX 5m60qr48p6n 1 4 developing develop VERB 5m60qr48p6n 1 5 at at ADP 5m60qr48p6n 1 6 an an DET 5m60qr48p6n 1 7 alarming alarming ADJ 5m60qr48p6n 1 8 rate rate NOUN 5m60qr48p6n 1 9 and and CCONJ 5m60qr48p6n 1 10 is be AUX 5m60qr48p6n 1 11 one one NUM 5m60qr48p6n 1 12 of of ADP 5m60qr48p6n 1 13 the the DET 5m60qr48p6n 1 14 world world NOUN 5m60qr48p6n 1 15 's 's PART 5m60qr48p6n 1 16 most most ADV 5m60qr48p6n 1 17 pressing press VERB 5m60qr48p6n 1 18 health health NOUN 5m60qr48p6n 1 19 problems problem NOUN 5m60qr48p6n 1 20 . . PUNCT 5m60qr48p6n 2 1 new new ADJ 5m60qr48p6n 2 2 methods method NOUN 5m60qr48p6n 2 3 for for ADP 5m60qr48p6n 2 4 developing develop VERB 5m60qr48p6n 2 5 microbe microbe NOUN 5m60qr48p6n 2 6 - - PUNCT 5m60qr48p6n 2 7 selective selective ADJ 5m60qr48p6n 2 8 antibacterial antibacterial ADJ 5m60qr48p6n 2 9 agents agent NOUN 5m60qr48p6n 2 10 including include VERB 5m60qr48p6n 2 11 novel novel ADJ 5m60qr48p6n 2 12 small small ADJ 5m60qr48p6n 2 13 molecules molecule NOUN 5m60qr48p6n 2 14 and and CCONJ 5m60qr48p6n 2 15 molecular molecular ADJ 5m60qr48p6n 2 16 antibiotic antibiotic ADJ 5m60qr48p6n 2 17 delivery delivery NOUN 5m60qr48p6n 2 18 systems system NOUN 5m60qr48p6n 2 19 that that PRON 5m60qr48p6n 2 20 challenge challenge VERB 5m60qr48p6n 2 21 existing exist VERB 5m60qr48p6n 2 22 bacterial bacterial ADJ 5m60qr48p6n 2 23 resistance resistance NOUN 5m60qr48p6n 2 24 mechanisms mechanism NOUN 5m60qr48p6n 2 25 and and CCONJ 5m60qr48p6n 2 26 limit limit VERB 5m60qr48p6n 2 27 the the DET 5m60qr48p6n 2 28 emergence emergence NOUN 5m60qr48p6n 2 29 of of ADP 5m60qr48p6n 2 30 resistance resistance NOUN 5m60qr48p6n 2 31 are be AUX 5m60qr48p6n 2 32 described describe VERB 5m60qr48p6n 2 33 in in ADP 5m60qr48p6n 2 34 this this DET 5m60qr48p6n 2 35 dissertation dissertation NOUN 5m60qr48p6n 2 36 . . PUNCT 5m60qr48p6n 3 1 siderophores siderophore NOUN 5m60qr48p6n 3 2 are be AUX 5m60qr48p6n 3 3 multidentate multidentate ADJ 5m60qr48p6n 3 4 fe(iii fe(iii NOUN 5m60qr48p6n 3 5 ) ) PUNCT 5m60qr48p6n 3 6 chelators chelator NOUN 5m60qr48p6n 3 7 used use VERB 5m60qr48p6n 3 8 by by ADP 5m60qr48p6n 3 9 bacteria bacteria NOUN 5m60qr48p6n 3 10 for for ADP 5m60qr48p6n 3 11 fe fe NOUN 5m60qr48p6n 3 12 - - PUNCT 5m60qr48p6n 3 13 assimilation assimilation NOUN 5m60qr48p6n 3 14 . . PUNCT 5m60qr48p6n 4 1 siderophores siderophore NOUN 5m60qr48p6n 4 2 are be AUX 5m60qr48p6n 4 3 important important ADJ 5m60qr48p6n 4 4 therapeutic therapeutic ADJ 5m60qr48p6n 4 5 agents agent NOUN 5m60qr48p6n 4 6 in in ADP 5m60qr48p6n 4 7 the the DET 5m60qr48p6n 4 8 treatment treatment NOUN 5m60qr48p6n 4 9 of of ADP 5m60qr48p6n 4 10 chronic chronic ADJ 5m60qr48p6n 4 11 fe fe PROPN 5m60qr48p6n 4 12 - - PUNCT 5m60qr48p6n 4 13 overload overload NOUN 5m60qr48p6n 4 14 diseases disease NOUN 5m60qr48p6n 4 15 . . PUNCT 5m60qr48p6n 5 1 sideromycins sideromycin NOUN 5m60qr48p6n 5 2 , , PUNCT 5m60qr48p6n 5 3 also also ADV 5m60qr48p6n 5 4 called call VERB 5m60qr48p6n 5 5 siderophore siderophore NOUN 5m60qr48p6n 5 6 - - PUNCT 5m60qr48p6n 5 7 antibiotic antibiotic ADJ 5m60qr48p6n 5 8 conjugates conjugate NOUN 5m60qr48p6n 5 9 , , PUNCT 5m60qr48p6n 5 10 are be AUX 5m60qr48p6n 5 11 a a DET 5m60qr48p6n 5 12 unique unique ADJ 5m60qr48p6n 5 13 subset subset NOUN 5m60qr48p6n 5 14 of of ADP 5m60qr48p6n 5 15 siderophores siderophore NOUN 5m60qr48p6n 5 16 that that PRON 5m60qr48p6n 5 17 enter enter VERB 5m60qr48p6n 5 18 bacterial bacterial ADJ 5m60qr48p6n 5 19 cells cell NOUN 5m60qr48p6n 5 20 via via ADP 5m60qr48p6n 5 21 siderophore siderophore NOUN 5m60qr48p6n 5 22 uptake uptake NOUN 5m60qr48p6n 5 23 pathways pathway NOUN 5m60qr48p6n 5 24 and and CCONJ 5m60qr48p6n 5 25 deliver deliver VERB 5m60qr48p6n 5 26 a a DET 5m60qr48p6n 5 27 toxic toxic ADJ 5m60qr48p6n 5 28 antibiotic antibiotic NOUN 5m60qr48p6n 5 29 in in ADP 5m60qr48p6n 5 30 a a DET 5m60qr48p6n 5 31 ' ' PUNCT 5m60qr48p6n 5 32 trojan trojan NOUN 5m60qr48p6n 5 33 horse horse NOUN 5m60qr48p6n 5 34 ' ' PART 5m60qr48p6n 5 35 fashion fashion NOUN 5m60qr48p6n 5 36 . . PUNCT 5m60qr48p6n 6 1 sideromycins sideromycin NOUN 5m60qr48p6n 6 2 represent represent VERB 5m60qr48p6n 6 3 a a DET 5m60qr48p6n 6 4 novel novel ADJ 5m60qr48p6n 6 5 antibiotic antibiotic ADJ 5m60qr48p6n 6 6 delivery delivery NOUN 5m60qr48p6n 6 7 technology technology NOUN 5m60qr48p6n 6 8 with with ADP 5m60qr48p6n 6 9 untapped untapped ADJ 5m60qr48p6n 6 10 potential potential NOUN 5m60qr48p6n 6 11 for for ADP 5m60qr48p6n 6 12 developing develop VERB 5m60qr48p6n 6 13 sophisticated sophisticated ADJ 5m60qr48p6n 6 14 microbe microbe NOUN 5m60qr48p6n 6 15 - - PUNCT 5m60qr48p6n 6 16 selective selective ADJ 5m60qr48p6n 6 17 antibacterial antibacterial ADJ 5m60qr48p6n 6 18 agents agent NOUN 5m60qr48p6n 6 19 . . PUNCT 5m60qr48p6n 7 1 significant significant ADJ 5m60qr48p6n 7 2 advancements advancement NOUN 5m60qr48p6n 7 3 in in ADP 5m60qr48p6n 7 4 the the DET 5m60qr48p6n 7 5 design design NOUN 5m60qr48p6n 7 6 , , PUNCT 5m60qr48p6n 7 7 syntheses synthesis NOUN 5m60qr48p6n 7 8 , , PUNCT 5m60qr48p6n 7 9 and and CCONJ 5m60qr48p6n 7 10 understanding understanding NOUN 5m60qr48p6n 7 11 of of ADP 5m60qr48p6n 7 12 sideromycins sideromycin NOUN 5m60qr48p6n 7 13 are be AUX 5m60qr48p6n 7 14 described describe VERB 5m60qr48p6n 7 15 in in ADP 5m60qr48p6n 7 16 chapters chapter NOUN 5m60qr48p6n 7 17 2 2 NUM 5m60qr48p6n 7 18 - - SYM 5m60qr48p6n 7 19 6 6 NUM 5m60qr48p6n 7 20 . . PUNCT 5m60qr48p6n 8 1 linear linear PROPN 5m60qr48p6n 8 2 trihydroxamate trihydroxamate PROPN 5m60qr48p6n 8 3 sideropohores sideropohore NOUN 5m60qr48p6n 8 4 were be AUX 5m60qr48p6n 8 5 found find VERB 5m60qr48p6n 8 6 to to PART 5m60qr48p6n 8 7 be be AUX 5m60qr48p6n 8 8 gram gram NOUN 5m60qr48p6n 8 9 - - PUNCT 5m60qr48p6n 8 10 positive positive ADJ 5m60qr48p6n 8 11 selective selective ADJ 5m60qr48p6n 8 12 antibiotic antibiotic ADJ 5m60qr48p6n 8 13 delivery delivery NOUN 5m60qr48p6n 8 14 vectors vector NOUN 5m60qr48p6n 8 15 and and CCONJ 5m60qr48p6n 8 16 the the DET 5m60qr48p6n 8 17 full full ADJ 5m60qr48p6n 8 18 trihydroxamate trihydroxamate ADJ 5m60qr48p6n 8 19 siderophore siderophore NOUN 5m60qr48p6n 8 20 backbone backbone NOUN 5m60qr48p6n 8 21 was be AUX 5m60qr48p6n 8 22 necessary necessary ADJ 5m60qr48p6n 8 23 for for ADP 5m60qr48p6n 8 24 siderophore siderophore NOUN 5m60qr48p6n 8 25 - - PUNCT 5m60qr48p6n 8 26 associated associate VERB 5m60qr48p6n 8 27 active active ADJ 5m60qr48p6n 8 28 transport transport NOUN 5m60qr48p6n 8 29 into into ADP 5m60qr48p6n 8 30 bacterial bacterial ADJ 5m60qr48p6n 8 31 cells cell NOUN 5m60qr48p6n 8 32 . . PUNCT 5m60qr48p6n 9 1 maintaining maintain VERB 5m60qr48p6n 9 2 high high ADJ 5m60qr48p6n 9 3 fe(iii)-affinity fe(iii)-affinity NOUN 5m60qr48p6n 9 4 was be AUX 5m60qr48p6n 9 5 important important ADJ 5m60qr48p6n 9 6 for for SCONJ 5m60qr48p6n 9 7 sideromycins sideromycin NOUN 5m60qr48p6n 9 8 to to PART 5m60qr48p6n 9 9 compete compete VERB 5m60qr48p6n 9 10 with with ADP 5m60qr48p6n 9 11 siderophores siderophore NOUN 5m60qr48p6n 9 12 for for ADP 5m60qr48p6n 9 13 entry entry NOUN 5m60qr48p6n 9 14 into into ADP 5m60qr48p6n 9 15 bacterial bacterial ADJ 5m60qr48p6n 9 16 cells cell NOUN 5m60qr48p6n 9 17 . . PUNCT 5m60qr48p6n 10 1 changing change VERB 5m60qr48p6n 10 2 the the DET 5m60qr48p6n 10 3 siderophore siderophore NOUN 5m60qr48p6n 10 4 structure structure NOUN 5m60qr48p6n 10 5 changed change VERB 5m60qr48p6n 10 6 the the DET 5m60qr48p6n 10 7 microbe microbe NOUN 5m60qr48p6n 10 8 - - PUNCT 5m60qr48p6n 10 9 selectivity selectivity NOUN 5m60qr48p6n 10 10 of of ADP 5m60qr48p6n 10 11 sideromycins sideromycin NOUN 5m60qr48p6n 10 12 . . PUNCT 5m60qr48p6n 11 1 antibiotics antibiotic NOUN 5m60qr48p6n 11 2 with with ADP 5m60qr48p6n 11 3 intracellular intracellular ADJ 5m60qr48p6n 11 4 targets target NOUN 5m60qr48p6n 11 5 were be AUX 5m60qr48p6n 11 6 useful useful ADJ 5m60qr48p6n 11 7 against against ADP 5m60qr48p6n 11 8 gram gram ADJ 5m60qr48p6n 11 9 - - PUNCT 5m60qr48p6n 11 10 positive positive ADJ 5m60qr48p6n 11 11 pathogens pathogen NOUN 5m60qr48p6n 11 12 and and CCONJ 5m60qr48p6n 11 13 antibiotics antibiotic NOUN 5m60qr48p6n 11 14 with with ADP 5m60qr48p6n 11 15 periplasmic periplasmic ADJ 5m60qr48p6n 11 16 targets target NOUN 5m60qr48p6n 11 17 were be AUX 5m60qr48p6n 11 18 useful useful ADJ 5m60qr48p6n 11 19 against against ADP 5m60qr48p6n 11 20 gram gram ADJ 5m60qr48p6n 11 21 - - PUNCT 5m60qr48p6n 11 22 negative negative ADJ 5m60qr48p6n 11 23 pathogens pathogen NOUN 5m60qr48p6n 11 24 . . PUNCT 5m60qr48p6n 12 1 sideromycins sideromycin NOUN 5m60qr48p6n 12 2 were be AUX 5m60qr48p6n 12 3 found find VERB 5m60qr48p6n 12 4 to to PART 5m60qr48p6n 12 5 bring bring VERB 5m60qr48p6n 12 6 new new ADJ 5m60qr48p6n 12 7 life life NOUN 5m60qr48p6n 12 8 to to ADP 5m60qr48p6n 12 9 antibiotics antibiotic NOUN 5m60qr48p6n 12 10 that that PRON 5m60qr48p6n 12 11 fail fail VERB 5m60qr48p6n 12 12 to to PART 5m60qr48p6n 12 13 enter enter VERB 5m60qr48p6n 12 14 bacterial bacterial ADJ 5m60qr48p6n 12 15 cells cell NOUN 5m60qr48p6n 12 16 due due ADJ 5m60qr48p6n 12 17 to to ADP 5m60qr48p6n 12 18 permeability permeability NOUN 5m60qr48p6n 12 19 problems problem NOUN 5m60qr48p6n 12 20 . . PUNCT 5m60qr48p6n 13 1 finally finally ADV 5m60qr48p6n 13 2 , , PUNCT 5m60qr48p6n 13 3 a a DET 5m60qr48p6n 13 4 microbe microbe NOUN 5m60qr48p6n 13 5 - - PUNCT 5m60qr48p6n 13 6 triggered trigger VERB 5m60qr48p6n 13 7 antibiotic antibiotic ADJ 5m60qr48p6n 13 8 release release NOUN 5m60qr48p6n 13 9 process process NOUN 5m60qr48p6n 13 10 was be AUX 5m60qr48p6n 13 11 not not PART 5m60qr48p6n 13 12 required require VERB 5m60qr48p6n 13 13 for for ADP 5m60qr48p6n 13 14 activity activity NOUN 5m60qr48p6n 13 15 , , PUNCT 5m60qr48p6n 13 16 but but CCONJ 5m60qr48p6n 13 17 was be AUX 5m60qr48p6n 13 18 desired desire VERB 5m60qr48p6n 13 19 to to PART 5m60qr48p6n 13 20 maximize maximize VERB 5m60qr48p6n 13 21 sideromycin sideromycin PROPN 5m60qr48p6n 13 22 potency potency PROPN 5m60qr48p6n 13 23 . . PUNCT 5m60qr48p6n 14 1 the the DET 5m60qr48p6n 14 2 work work NOUN 5m60qr48p6n 14 3 from from ADP 5m60qr48p6n 14 4 chapters chapter NOUN 5m60qr48p6n 14 5 2 2 NUM 5m60qr48p6n 14 6 - - SYM 5m60qr48p6n 14 7 6 6 NUM 5m60qr48p6n 14 8 culminated culminate VERB 5m60qr48p6n 14 9 with with ADP 5m60qr48p6n 14 10 the the DET 5m60qr48p6n 14 11 discovery discovery NOUN 5m60qr48p6n 14 12 of of ADP 5m60qr48p6n 14 13 a a DET 5m60qr48p6n 14 14 trihydroxamate trihydroxamate NOUN 5m60qr48p6n 14 15 - - PUNCT 5m60qr48p6n 14 16 fluoroquinolone fluoroquinolone NOUN 5m60qr48p6n 14 17 sideromycin sideromycin PROPN 5m60qr48p6n 14 18 with with ADP 5m60qr48p6n 14 19 potent potent ADJ 5m60qr48p6n 14 20 and and CCONJ 5m60qr48p6n 14 21 selective selective ADJ 5m60qr48p6n 14 22 activity activity NOUN 5m60qr48p6n 14 23 against against ADP 5m60qr48p6n 14 24 staphylococcus staphylococcus PROPN 5m60qr48p6n 14 25 aureus aureus PROPN 5m60qr48p6n 14 26 sg511 sg511 PROPN 5m60qr48p6n 14 27 ( ( PUNCT 5m60qr48p6n 14 28 mic90=1 mic90=1 PROPN 5m60qr48p6n 14 29 ìâm ìâm PROPN 5m60qr48p6n 14 30 ) ) PUNCT 5m60qr48p6n 14 31 and and CCONJ 5m60qr48p6n 14 32 a a DET 5m60qr48p6n 14 33 mixed mixed ADJ 5m60qr48p6n 14 34 ligand ligand NOUN 5m60qr48p6n 14 35 biscatecholate biscatecholate NOUN 5m60qr48p6n 14 36 - - PUNCT 5m60qr48p6n 14 37 monohydroxamate monohydroxamate ADJ 5m60qr48p6n 14 38 - - PUNCT 5m60qr48p6n 14 39 ì¢-lactam ì¢-lactam ADJ 5m60qr48p6n 14 40 sideromycin sideromycin PROPN 5m60qr48p6n 14 41 with with ADP 5m60qr48p6n 14 42 potent potent ADJ 5m60qr48p6n 14 43 and and CCONJ 5m60qr48p6n 14 44 selective selective ADJ 5m60qr48p6n 14 45 activity activity NOUN 5m60qr48p6n 14 46 against against ADP 5m60qr48p6n 14 47 acinetobacter acinetobacter ADJ 5m60qr48p6n 14 48 baumanii baumanii PROPN 5m60qr48p6n 14 49 atcc atcc PROPN 5m60qr48p6n 14 50 17961 17961 NUM 5m60qr48p6n 14 51 ( ( PUNCT 5m60qr48p6n 14 52 mic90=0.0078 mic90=0.0078 NOUN 5m60qr48p6n 14 53 nm nm NOUN 5m60qr48p6n 14 54 ) ) PUNCT 5m60qr48p6n 14 55 . . PUNCT 5m60qr48p6n 15 1 the the DET 5m60qr48p6n 15 2 discovery discovery NOUN 5m60qr48p6n 15 3 of of ADP 5m60qr48p6n 15 4 a a DET 5m60qr48p6n 15 5 structurally structurally ADV 5m60qr48p6n 15 6 novel novel ADJ 5m60qr48p6n 15 7 small small ADJ 5m60qr48p6n 15 8 molecule molecule NOUN 5m60qr48p6n 15 9 antibacterial antibacterial ADJ 5m60qr48p6n 15 10 scaffold scaffold NOUN 5m60qr48p6n 15 11 based base VERB 5m60qr48p6n 15 12 on on ADP 5m60qr48p6n 15 13 n n NOUN 5m60qr48p6n 15 14 - - PUNCT 5m60qr48p6n 15 15 alkyl alkyl ADJ 5m60qr48p6n 15 16 - - PUNCT 5m60qr48p6n 15 17 n-(pyridin-2 n-(pyridin-2 NUM 5m60qr48p6n 15 18 - - PUNCT 5m60qr48p6n 15 19 yl)hydroxylamines yl)hydroxylamine NOUN 5m60qr48p6n 15 20 is be AUX 5m60qr48p6n 15 21 described describe VERB 5m60qr48p6n 15 22 in in ADP 5m60qr48p6n 15 23 chapter chapter NOUN 5m60qr48p6n 15 24 7 7 NUM 5m60qr48p6n 15 25 . . PUNCT 5m60qr48p6n 16 1 the the DET 5m60qr48p6n 16 2 scaffold scaffold NOUN 5m60qr48p6n 16 3 was be AUX 5m60qr48p6n 16 4 discovered discover VERB 5m60qr48p6n 16 5 from from ADP 5m60qr48p6n 16 6 antibacterial antibacterial ADJ 5m60qr48p6n 16 7 testing testing NOUN 5m60qr48p6n 16 8 of of ADP 5m60qr48p6n 16 9 a a DET 5m60qr48p6n 16 10 compound compound NOUN 5m60qr48p6n 16 11 library library NOUN 5m60qr48p6n 16 12 generated generate VERB 5m60qr48p6n 16 13 from from ADP 5m60qr48p6n 16 14 nitroso nitroso NOUN 5m60qr48p6n 16 15 diels diel NOUN 5m60qr48p6n 16 16 - - PUNCT 5m60qr48p6n 16 17 alder alder NOUN 5m60qr48p6n 16 18 and and CCONJ 5m60qr48p6n 16 19 ene ene ADJ 5m60qr48p6n 16 20 chemistry chemistry NOUN 5m60qr48p6n 16 21 . . PUNCT 5m60qr48p6n 17 1 the the DET 5m60qr48p6n 17 2 scaffold scaffold NOUN 5m60qr48p6n 17 3 had have VERB 5m60qr48p6n 17 4 selective selective ADJ 5m60qr48p6n 17 5 and and CCONJ 5m60qr48p6n 17 6 potent potent ADJ 5m60qr48p6n 17 7 antibacterial antibacterial ADJ 5m60qr48p6n 17 8 activity activity NOUN 5m60qr48p6n 17 9 against against ADP 5m60qr48p6n 17 10 micrococcus micrococcus PROPN 5m60qr48p6n 17 11 luteus luteus PROPN 5m60qr48p6n 17 12 atcc atcc PROPN 5m60qr48p6n 17 13 10240 10240 NUM 5m60qr48p6n 17 14 ( ( PUNCT 5m60qr48p6n 17 15 mic90=2 mic90=2 PROPN 5m60qr48p6n 17 16 ìâm ìâm PROPN 5m60qr48p6n 17 17 ) ) PUNCT 5m60qr48p6n 17 18 and and CCONJ 5m60qr48p6n 17 19 other other ADJ 5m60qr48p6n 17 20 gram gram ADJ 5m60qr48p6n 17 21 - - PUNCT 5m60qr48p6n 17 22 positive positive ADJ 5m60qr48p6n 17 23 organisms organism NOUN 5m60qr48p6n 17 24 , , PUNCT 5m60qr48p6n 17 25 including include VERB 5m60qr48p6n 17 26 resistant resistant ADJ 5m60qr48p6n 17 27 strains strain NOUN 5m60qr48p6n 17 28 of of ADP 5m60qr48p6n 17 29 s. s. PROPN 5m60qr48p6n 17 30 aureus aureus PROPN 5m60qr48p6n 17 31 ( ( PUNCT 5m60qr48p6n 17 32 mrsa mrsa PROPN 5m60qr48p6n 17 33 ) ) PUNCT 5m60qr48p6n 17 34 and and CCONJ 5m60qr48p6n 17 35 e. e. PROPN 5m60qr48p6n 17 36 faecalis faecalis PROPN 5m60qr48p6n 17 37 ( ( PUNCT 5m60qr48p6n 17 38 vre vre NOUN 5m60qr48p6n 17 39 ) ) PUNCT 5m60qr48p6n 17 40 . . PUNCT