id sid tid token lemma pos 70795714j8k 1 1 the the DET 70795714j8k 1 2 zebrafish zebrafish ADJ 70795714j8k 1 3 lens lens NOUN 70795714j8k 1 4 opaque opaque ADJ 70795714j8k 1 5 ( ( PUNCT 70795714j8k 1 6 lop lop PROPN 70795714j8k 1 7 ) ) PUNCT 70795714j8k 1 8 mutant mutant NOUN 70795714j8k 1 9 was be AUX 70795714j8k 1 10 identified identify VERB 70795714j8k 1 11 in in ADP 70795714j8k 1 12 a a DET 70795714j8k 1 13 mutagenesis mutagenesis NOUN 70795714j8k 1 14 screen screen NOUN 70795714j8k 1 15 for for ADP 70795714j8k 1 16 eye eye NOUN 70795714j8k 1 17 morphological morphological ADJ 70795714j8k 1 18 phenotypes phenotype NOUN 70795714j8k 1 19 , , PUNCT 70795714j8k 1 20 and and CCONJ 70795714j8k 1 21 exhibits exhibit VERB 70795714j8k 1 22 lens lens NOUN 70795714j8k 1 23 opacity opacity NOUN 70795714j8k 1 24 at at ADP 70795714j8k 1 25 7 7 NUM 70795714j8k 1 26 days day NOUN 70795714j8k 1 27 post post NOUN 70795714j8k 1 28 fertilization fertilization NOUN 70795714j8k 1 29 due due ADP 70795714j8k 1 30 to to ADP 70795714j8k 1 31 unregulated unregulated ADJ 70795714j8k 1 32 lens lens NOUN 70795714j8k 1 33 epithelial epithelial ADJ 70795714j8k 1 34 cell cell NOUN 70795714j8k 1 35 proliferation proliferation NOUN 70795714j8k 1 36 and and CCONJ 70795714j8k 1 37 fiber fiber NOUN 70795714j8k 1 38 cell cell NOUN 70795714j8k 1 39 degeneration degeneration NOUN 70795714j8k 1 40 . . PUNCT 70795714j8k 2 1 the the DET 70795714j8k 2 2 lop lop PROPN 70795714j8k 2 3 mutation mutation NOUN 70795714j8k 2 4 was be AUX 70795714j8k 2 5 shown show VERB 70795714j8k 2 6 to to PART 70795714j8k 2 7 be be AUX 70795714j8k 2 8 a a DET 70795714j8k 2 9 missense missense NOUN 70795714j8k 2 10 mutation mutation NOUN 70795714j8k 2 11 ( ( PUNCT 70795714j8k 2 12 a331 a331 PROPN 70795714j8k 2 13 t t PROPN 70795714j8k 2 14 ) ) PUNCT 70795714j8k 2 15 in in ADP 70795714j8k 2 16 the the DET 70795714j8k 2 17 cdipt cdipt PROPN 70795714j8k 2 18 ( ( PUNCT 70795714j8k 2 19 cdp cdp PROPN 70795714j8k 2 20 - - PUNCT 70795714j8k 2 21 diacylglycerol diacylglycerol PROPN 70795714j8k 2 22 -- -- PUNCT 70795714j8k 2 23 inositol inositol NOUN 70795714j8k 2 24 3 3 NUM 70795714j8k 2 25 - - PUNCT 70795714j8k 2 26 phosphatidyltransferase phosphatidyltransferase NOUN 70795714j8k 2 27 ; ; PUNCT 70795714j8k 2 28 phosphatidylinositol phosphatidylinositol NOUN 70795714j8k 2 29 ( ( PUNCT 70795714j8k 2 30 pi pi NOUN 70795714j8k 2 31 ) ) PUNCT 70795714j8k 2 32 synthase synthase NOUN 70795714j8k 2 33 ) ) PUNCT 70795714j8k 2 34 gene gene NOUN 70795714j8k 2 35 , , PUNCT 70795714j8k 2 36 resulting result VERB 70795714j8k 2 37 in in ADP 70795714j8k 2 38 an an DET 70795714j8k 2 39 s111c s111c ADJ 70795714j8k 2 40 substitution substitution NOUN 70795714j8k 2 41 in in ADP 70795714j8k 2 42 the the DET 70795714j8k 2 43 encoded encode VERB 70795714j8k 2 44 protein protein NOUN 70795714j8k 2 45 . . PUNCT 70795714j8k 3 1 a a DET 70795714j8k 3 2 second second ADJ 70795714j8k 3 3 allele allele NOUN 70795714j8k 3 4 , , PUNCT 70795714j8k 3 5 cdipthi559 cdipthi559 PROPN 70795714j8k 3 6 , , PUNCT 70795714j8k 3 7 was be AUX 70795714j8k 3 8 previously previously ADV 70795714j8k 3 9 described describe VERB 70795714j8k 3 10 as as ADP 70795714j8k 3 11 possessing possess VERB 70795714j8k 3 12 a a DET 70795714j8k 3 13 viral viral ADJ 70795714j8k 3 14 insertion insertion NOUN 70795714j8k 3 15 in in ADP 70795714j8k 3 16 the the DET 70795714j8k 3 17 first first ADJ 70795714j8k 3 18 intron intron NOUN 70795714j8k 3 19 and and CCONJ 70795714j8k 3 20 failed fail VERB 70795714j8k 3 21 to to PART 70795714j8k 3 22 complement complement VERB 70795714j8k 3 23 cdiptlop cdiptlop PROPN 70795714j8k 3 24 . . PUNCT 70795714j8k 4 1 morpholino morpholino ADJ 70795714j8k 4 2 - - PUNCT 70795714j8k 4 3 mediated mediate VERB 70795714j8k 4 4 knockdown knockdown NOUN 70795714j8k 4 5 of of ADP 70795714j8k 4 6 pi pi NOUN 70795714j8k 4 7 synthase synthase NOUN 70795714j8k 4 8 and and CCONJ 70795714j8k 4 9 cdipt cdipt PROPN 70795714j8k 4 10 mrna mrna PROPN 70795714j8k 4 11 micro micro PROPN 70795714j8k 4 12 - - NOUN 70795714j8k 4 13 injection injection NOUN 70795714j8k 4 14 rescue rescue NOUN 70795714j8k 4 15 confirmed confirm VERB 70795714j8k 4 16 the the DET 70795714j8k 4 17 gene gene NOUN 70795714j8k 4 18 identity identity NOUN 70795714j8k 4 19 . . PUNCT 70795714j8k 5 1 to to PART 70795714j8k 5 2 examine examine VERB 70795714j8k 5 3 the the DET 70795714j8k 5 4 initial initial ADJ 70795714j8k 5 5 cellular cellular ADJ 70795714j8k 5 6 defects defect NOUN 70795714j8k 5 7 associated associate VERB 70795714j8k 5 8 with with ADP 70795714j8k 5 9 the the DET 70795714j8k 5 10 cdipt cdipt ADJ 70795714j8k 5 11 mutant mutant NOUN 70795714j8k 5 12 , , PUNCT 70795714j8k 5 13 pcr pcr ADV 70795714j8k 5 14 - - PUNCT 70795714j8k 5 15 based base VERB 70795714j8k 5 16 genotyping genotyping NOUN 70795714j8k 5 17 to to ADP 70795714j8k 5 18 identified identify VERB 70795714j8k 5 19 homozygous homozygous ADJ 70795714j8k 5 20 cdipthi559 cdipthi559 NOUN 70795714j8k 5 21 / / SYM 70795714j8k 5 22 hi559 hi559 X 70795714j8k 5 23 mutants mutant VERB 70795714j8k 5 24 prior prior ADV 70795714j8k 5 25 to to ADP 70795714j8k 5 26 lens lens NOUN 70795714j8k 5 27 opacification opacification NOUN 70795714j8k 5 28 . . PUNCT 70795714j8k 6 1 the the DET 70795714j8k 6 2 cdipthi559 cdipthi559 PROPN 70795714j8k 6 3 / / SYM 70795714j8k 6 4 hi559 hi559 X 70795714j8k 6 5 mutant mutant NOUN 70795714j8k 6 6 exhibited exhibit VERB 70795714j8k 6 7 photoreceptor photoreceptor NOUN 70795714j8k 6 8 disruption disruption NOUN 70795714j8k 6 9 and and CCONJ 70795714j8k 6 10 cell cell NOUN 70795714j8k 6 11 death death NOUN 70795714j8k 6 12 at at ADP 70795714j8k 6 13 3 3 NUM 70795714j8k 6 14 and and CCONJ 70795714j8k 6 15 4 4 NUM 70795714j8k 6 16 dpf dpf NOUN 70795714j8k 6 17 , , PUNCT 70795714j8k 6 18 respectively respectively ADV 70795714j8k 6 19 , , PUNCT 70795714j8k 6 20 followed follow VERB 70795714j8k 6 21 by by ADP 70795714j8k 6 22 lens lens NOUN 70795714j8k 6 23 dismorphogenesis dismorphogenesis NOUN 70795714j8k 6 24 by by ADP 70795714j8k 6 25 5 5 NUM 70795714j8k 6 26 dpf dpf NOUN 70795714j8k 6 27 . . PUNCT 70795714j8k 7 1 anti anti ADJ 70795714j8k 7 2 - - ADJ 70795714j8k 7 3 zebrafish zebrafish ADJ 70795714j8k 7 4 pi pi NOUN 70795714j8k 7 5 synthase synthase NOUN 70795714j8k 7 6 polyclonal polyclonal PROPN 70795714j8k 7 7 antiserum antiserum NOUN 70795714j8k 7 8 localized localize VERB 70795714j8k 7 9 the the DET 70795714j8k 7 10 protein protein NOUN 70795714j8k 7 11 throughout throughout ADP 70795714j8k 7 12 the the DET 70795714j8k 7 13 developing develop VERB 70795714j8k 7 14 wild wild ADJ 70795714j8k 7 15 - - PUNCT 70795714j8k 7 16 type type NOUN 70795714j8k 7 17 eye eye NOUN 70795714j8k 7 18 , , PUNCT 70795714j8k 7 19 including include VERB 70795714j8k 7 20 the the DET 70795714j8k 7 21 photoreceptor photoreceptor NOUN 70795714j8k 7 22 layer layer NOUN 70795714j8k 7 23 and and CCONJ 70795714j8k 7 24 lens lens NOUN 70795714j8k 7 25 cortical cortical ADJ 70795714j8k 7 26 secondary secondary ADJ 70795714j8k 7 27 fiber fiber NOUN 70795714j8k 7 28 cells cell NOUN 70795714j8k 7 29 , , PUNCT 70795714j8k 7 30 but but CCONJ 70795714j8k 7 31 the the DET 70795714j8k 7 32 protein protein NOUN 70795714j8k 7 33 was be AUX 70795714j8k 7 34 reduced reduce VERB 70795714j8k 7 35 in in ADP 70795714j8k 7 36 both both PRON 70795714j8k 7 37 the the DET 70795714j8k 7 38 cdiptlop cdiptlop PROPN 70795714j8k 7 39 / / SYM 70795714j8k 7 40 lop lop PROPN 70795714j8k 7 41 and and CCONJ 70795714j8k 7 42 cdipthi559 cdipthi559 PROPN 70795714j8k 7 43 / / SYM 70795714j8k 7 44 hi559 hi559 X 70795714j8k 7 45 mutants mutant NOUN 70795714j8k 7 46 . . PUNCT 70795714j8k 8 1 moreover moreover ADV 70795714j8k 8 2 , , PUNCT 70795714j8k 8 3 tetrad tetrad ADJ 70795714j8k 8 4 analysis analysis NOUN 70795714j8k 8 5 of of ADP 70795714j8k 8 6 a a DET 70795714j8k 8 7 heterozygous heterozygous ADJ 70795714j8k 8 8 pis1diploid pis1diploid ADJ 70795714j8k 8 9 yeast yeast NOUN 70795714j8k 8 10 strain strain NOUN 70795714j8k 8 11 transformed transform VERB 70795714j8k 8 12 with with ADP 70795714j8k 8 13 either either CCONJ 70795714j8k 8 14 wild wild ADJ 70795714j8k 8 15 - - PUNCT 70795714j8k 8 16 type type NOUN 70795714j8k 8 17 or or CCONJ 70795714j8k 8 18 cdiptlop cdiptlop PROPN 70795714j8k 8 19 zebrafish zebrafish PROPN 70795714j8k 8 20 cdnas cdnas PROPN 70795714j8k 8 21 demonstrated demonstrate VERB 70795714j8k 8 22 that that SCONJ 70795714j8k 8 23 both both DET 70795714j8k 8 24 proteins protein NOUN 70795714j8k 8 25 possessed possess VERB 70795714j8k 8 26 pi pi NOUN 70795714j8k 8 27 synthase synthase NOUN 70795714j8k 8 28 activity activity NOUN 70795714j8k 8 29 . . PUNCT 70795714j8k 9 1 to to PART 70795714j8k 9 2 identify identify VERB 70795714j8k 9 3 signaling signal VERB 70795714j8k 9 4 pathways pathway NOUN 70795714j8k 9 5 that that PRON 70795714j8k 9 6 may may AUX 70795714j8k 9 7 be be AUX 70795714j8k 9 8 disrupted disrupt VERB 70795714j8k 9 9 in in ADP 70795714j8k 9 10 the the DET 70795714j8k 9 11 cdipt cdipt ADJ 70795714j8k 9 12 mutant mutant ADJ 70795714j8k 9 13 eye eye NOUN 70795714j8k 9 14 , , PUNCT 70795714j8k 9 15 global global ADJ 70795714j8k 9 16 gene gene NOUN 70795714j8k 9 17 expression expression NOUN 70795714j8k 9 18 changes change NOUN 70795714j8k 9 19 were be AUX 70795714j8k 9 20 analyzed analyze VERB 70795714j8k 9 21 by by ADP 70795714j8k 9 22 comparative comparative ADJ 70795714j8k 9 23 microarray microarray PROPN 70795714j8k 9 24 hybridization hybridization PROPN 70795714j8k 9 25 using use VERB 70795714j8k 9 26 rna rna PROPN 70795714j8k 9 27 extracted extract VERB 70795714j8k 9 28 from from ADP 70795714j8k 9 29 cdiptlop cdiptlop PROPN 70795714j8k 9 30 / / SYM 70795714j8k 9 31 lop lop PROPN 70795714j8k 9 32 mutant mutant ADJ 70795714j8k 9 33 and and CCONJ 70795714j8k 9 34 wild wild ADJ 70795714j8k 9 35 - - PUNCT 70795714j8k 9 36 type type NOUN 70795714j8k 9 37 eyes eye NOUN 70795714j8k 9 38 . . PUNCT 70795714j8k 10 1 in in ADP 70795714j8k 10 2 a a DET 70795714j8k 10 3 complimentary complimentary ADJ 70795714j8k 10 4 approach approach NOUN 70795714j8k 10 5 , , PUNCT 70795714j8k 10 6 protein protein NOUN 70795714j8k 10 7 was be AUX 70795714j8k 10 8 isolated isolate VERB 70795714j8k 10 9 from from ADP 70795714j8k 10 10 cdiptlop cdiptlop PROPN 70795714j8k 10 11 / / SYM 70795714j8k 10 12 lop lop PROPN 70795714j8k 10 13 mutant mutant ADJ 70795714j8k 10 14 and and CCONJ 70795714j8k 10 15 wild wild ADJ 70795714j8k 10 16 - - PUNCT 70795714j8k 10 17 type type NOUN 70795714j8k 10 18 eyes eye NOUN 70795714j8k 10 19 and and CCONJ 70795714j8k 10 20 analyzed analyze VERB 70795714j8k 10 21 by by ADP 70795714j8k 10 22 fluorescent fluorescent NOUN 70795714j8k 10 23 2d 2d NOUN 70795714j8k 10 24 difference difference NOUN 70795714j8k 10 25 gel gel NOUN 70795714j8k 10 26 electrophoresis electrophoresis NOUN 70795714j8k 10 27 , , PUNCT 70795714j8k 10 28 followed follow VERB 70795714j8k 10 29 by by ADP 70795714j8k 10 30 mass mass ADJ 70795714j8k 10 31 spectrometry spectrometry NOUN 70795714j8k 10 32 of of ADP 70795714j8k 10 33 differentially differentially ADV 70795714j8k 10 34 expressed express VERB 70795714j8k 10 35 proteins protein NOUN 70795714j8k 10 36 . . PUNCT 70795714j8k 11 1 the the DET 70795714j8k 11 2 resulting result VERB 70795714j8k 11 3 proteomic proteomic ADJ 70795714j8k 11 4 data datum NOUN 70795714j8k 11 5 complemented complement VERB 70795714j8k 11 6 the the DET 70795714j8k 11 7 transcriptome transcriptome ADJ 70795714j8k 11 8 analysis analysis NOUN 70795714j8k 11 9 , , PUNCT 70795714j8k 11 10 with with ADP 70795714j8k 11 11 both both DET 70795714j8k 11 12 approaches approach NOUN 70795714j8k 11 13 identifying identify VERB 70795714j8k 11 14 components component NOUN 70795714j8k 11 15 in in ADP 70795714j8k 11 16 the the DET 70795714j8k 11 17 pi pi NOUN 70795714j8k 11 18 3 3 NUM 70795714j8k 11 19 - - PUNCT 70795714j8k 11 20 kinase kinase ADJ 70795714j8k 11 21 signaling signal VERB 70795714j8k 11 22 pathway pathway NOUN 70795714j8k 11 23 . . PUNCT 70795714j8k 12 1 additionally additionally ADV 70795714j8k 12 2 , , PUNCT 70795714j8k 12 3 differentially differentially ADV 70795714j8k 12 4 regulated regulate VERB 70795714j8k 12 5 genes gene NOUN 70795714j8k 12 6 were be AUX 70795714j8k 12 7 identified identify VERB 70795714j8k 12 8 that that SCONJ 70795714j8k 12 9 correlated correlate VERB 70795714j8k 12 10 with with ADP 70795714j8k 12 11 genes gene NOUN 70795714j8k 12 12 previously previously ADV 70795714j8k 12 13 identified identify VERB 70795714j8k 12 14 with with ADP 70795714j8k 12 15 human human ADJ 70795714j8k 12 16 anterior anterior ADJ 70795714j8k 12 17 subcapsular subcapsular ADJ 70795714j8k 12 18 cataracts cataract NOUN 70795714j8k 12 19 . . PUNCT 70795714j8k 13 1 through through ADP 70795714j8k 13 2 phenotypic phenotypic ADJ 70795714j8k 13 3 , , PUNCT 70795714j8k 13 4 transcriptomic transcriptomic ADJ 70795714j8k 13 5 and and CCONJ 70795714j8k 13 6 proteomic proteomic ADJ 70795714j8k 13 7 analyses analysis NOUN 70795714j8k 13 8 , , PUNCT 70795714j8k 13 9 the the DET 70795714j8k 13 10 zebrafish zebrafish NOUN 70795714j8k 13 11 cdipt cdipt ADJ 70795714j8k 13 12 alleles allele NOUN 70795714j8k 13 13 represent represent VERB 70795714j8k 13 14 an an DET 70795714j8k 13 15 excellent excellent NOUN 70795714j8k 13 16 in in ADP 70795714j8k 13 17 vivo vivo ADJ 70795714j8k 13 18 model model NOUN 70795714j8k 13 19 to to PART 70795714j8k 13 20 investigate investigate VERB 70795714j8k 13 21 the the DET 70795714j8k 13 22 contribution contribution NOUN 70795714j8k 13 23 of of ADP 70795714j8k 13 24 phosphoinositide phosphoinositide NOUN 70795714j8k 13 25 - - PUNCT 70795714j8k 13 26 associated associate VERB 70795714j8k 13 27 signaling signal VERB 70795714j8k 13 28 pathways pathway NOUN 70795714j8k 13 29 in in ADP 70795714j8k 13 30 maintaining maintain VERB 70795714j8k 13 31 lens lens NOUN 70795714j8k 13 32 clarity clarity NOUN 70795714j8k 13 33 and and CCONJ 70795714j8k 13 34 photoreceptor photoreceptor NOUN 70795714j8k 13 35 cell cell NOUN 70795714j8k 13 36 integrity integrity NOUN 70795714j8k 13 37 . . PUNCT