id	sid	tid	token	lemma	pos
73666397v54	1	1	it	it	PRON
73666397v54	1	2	has	have	AUX
73666397v54	1	3	become	become	VERB
73666397v54	1	4	more	more	ADV
73666397v54	1	5	evident	evident	ADJ
73666397v54	1	6	that	that	SCONJ
73666397v54	1	7	many	many	ADJ
73666397v54	1	8	proteins	protein	NOUN
73666397v54	1	9	experience	experience	VERB
73666397v54	1	10	activity	activity	NOUN
73666397v54	1	11	regulation	regulation	NOUN
73666397v54	1	12	via	via	ADP
73666397v54	1	13	binding	bind	VERB
73666397v54	1	14	of	of	ADP
73666397v54	1	15	small	small	ADJ
73666397v54	1	16	molecules	molecule	NOUN
73666397v54	1	17	or	or	CCONJ
73666397v54	1	18	other	other	ADJ
73666397v54	1	19	proteins	protein	NOUN
73666397v54	1	20	to	to	ADP
73666397v54	1	21	sites	site	NOUN
73666397v54	1	22	that	that	PRON
73666397v54	1	23	are	be	AUX
73666397v54	1	24	distal	distal	ADJ
73666397v54	1	25	from	from	ADP
73666397v54	1	26	the	the	DET
73666397v54	1	27	active	active	ADJ
73666397v54	1	28	site	site	NOUN
73666397v54	1	29	.	.	PUNCT
73666397v54	2	1	this	this	DET
73666397v54	2	2	phenomenon	phenomenon	NOUN
73666397v54	2	3	,	,	PUNCT
73666397v54	2	4	commonly	commonly	ADV
73666397v54	2	5	referred	refer	VERB
73666397v54	2	6	to	to	ADP
73666397v54	2	7	as	as	ADP
73666397v54	2	8	allostery	allostery	NOUN
73666397v54	2	9	,	,	PUNCT
73666397v54	2	10	plays	play	VERB
73666397v54	2	11	an	an	DET
73666397v54	2	12	important	important	ADJ
73666397v54	2	13	role	role	NOUN
73666397v54	2	14	as	as	ADP
73666397v54	2	15	a	a	DET
73666397v54	2	16	mechanism	mechanism	NOUN
73666397v54	2	17	for	for	ADP
73666397v54	2	18	signal	signal	NOUN
73666397v54	2	19	transduction	transduction	NOUN
73666397v54	2	20	within	within	ADP
73666397v54	2	21	and	and	CCONJ
73666397v54	2	22	between	between	ADP
73666397v54	2	23	proteins	protein	NOUN
73666397v54	2	24	to	to	PART
73666397v54	2	25	make	make	VERB
73666397v54	2	26	up	up	ADP
73666397v54	2	27	the	the	DET
73666397v54	2	28	complex	complex	ADJ
73666397v54	2	29	cellular	cellular	ADJ
73666397v54	2	30	information	information	NOUN
73666397v54	2	31	networks	network	NOUN
73666397v54	2	32	.	.	PUNCT
73666397v54	3	1	proteins	protein	NOUN
73666397v54	3	2	of	of	ADP
73666397v54	3	3	modular	modular	ADJ
73666397v54	3	4	design	design	NOUN
73666397v54	3	5	represent	represent	VERB
73666397v54	3	6	a	a	DET
73666397v54	3	7	unique	unique	ADJ
73666397v54	3	8	class	class	NOUN
73666397v54	3	9	of	of	ADP
73666397v54	3	10	proteins	protein	NOUN
73666397v54	3	11	that	that	PRON
73666397v54	3	12	construct	construct	VERB
73666397v54	3	13	such	such	ADJ
73666397v54	3	14	information	information	NOUN
73666397v54	3	15	systems	system	NOUN
73666397v54	3	16	whereby	whereby	SCONJ
73666397v54	3	17	a	a	DET
73666397v54	3	18	docking	docking	NOUN
73666397v54	3	19	module	module	NOUN
73666397v54	3	20	and	and	CCONJ
73666397v54	3	21	a	a	DET
73666397v54	3	22	loosely	loosely	ADV
73666397v54	3	23	connected	connect	VERB
73666397v54	3	24	module	module	NOUN
73666397v54	3	25	of	of	ADP
73666397v54	3	26	catalytic	catalytic	ADJ
73666397v54	3	27	function	function	NOUN
73666397v54	3	28	operate	operate	VERB
73666397v54	3	29	in	in	ADP
73666397v54	3	30	concert	concert	NOUN
73666397v54	3	31	to	to	PART
73666397v54	3	32	achieve	achieve	VERB
73666397v54	3	33	optimal	optimal	ADJ
73666397v54	3	34	activity	activity	NOUN
73666397v54	3	35	for	for	ADP
73666397v54	3	36	the	the	DET
73666397v54	3	37	viability	viability	NOUN
73666397v54	3	38	of	of	ADP
73666397v54	3	39	the	the	DET
73666397v54	3	40	cell	cell	NOUN
73666397v54	3	41	.	.	PUNCT
73666397v54	4	1	in	in	ADP
73666397v54	4	2	this	this	DET
73666397v54	4	3	case	case	NOUN
73666397v54	4	4	,	,	PUNCT
73666397v54	4	5	inter	inter	ADJ
73666397v54	4	6	-	-	NOUN
73666397v54	4	7	domain	domain	ADJ
73666397v54	4	8	signal	signal	NOUN
73666397v54	4	9	transduction	transduction	NOUN
73666397v54	4	10	is	be	AUX
73666397v54	4	11	carried	carry	VERB
73666397v54	4	12	out	out	ADP
73666397v54	4	13	by	by	ADP
73666397v54	4	14	the	the	DET
73666397v54	4	15	process	process	NOUN
73666397v54	4	16	known	know	VERB
73666397v54	4	17	as	as	ADP
73666397v54	4	18	modular	modular	ADJ
73666397v54	4	19	allostery	allostery	NOUN
73666397v54	4	20	.	.	PUNCT
73666397v54	5	1	unlike	unlike	ADP
73666397v54	5	2	the	the	DET
73666397v54	5	3	classic	classic	ADJ
73666397v54	5	4	intra	intra	ADJ
73666397v54	5	5	-	-	ADJ
73666397v54	5	6	domain	domain	ADJ
73666397v54	5	7	allosteric	allosteric	NOUN
73666397v54	5	8	mechanism	mechanism	NOUN
73666397v54	5	9	,	,	PUNCT
73666397v54	5	10	modular	modular	ADJ
73666397v54	5	11	allostery	allostery	NOUN
73666397v54	5	12	is	be	AUX
73666397v54	5	13	also	also	ADV
73666397v54	5	14	associated	associate	VERB
73666397v54	5	15	with	with	ADP
73666397v54	5	16	large	large	ADJ
73666397v54	5	17	inter	inter	ADJ
73666397v54	5	18	-	-	ADJ
73666397v54	5	19	domain	domain	ADJ
73666397v54	5	20	structural	structural	ADJ
73666397v54	5	21	transitions	transition	NOUN
73666397v54	5	22	to	to	PART
73666397v54	5	23	regulate	regulate	VERB
73666397v54	5	24	activity	activity	NOUN
73666397v54	5	25	.	.	PUNCT
73666397v54	6	1	for	for	ADP
73666397v54	6	2	instance	instance	NOUN
73666397v54	6	3	,	,	PUNCT
73666397v54	6	4	ligand	ligand	VERB
73666397v54	6	5	binding	bind	VERB
73666397v54	6	6	at	at	ADP
73666397v54	6	7	one	one	NUM
73666397v54	6	8	domain	domain	NOUN
73666397v54	6	9	may	may	AUX
73666397v54	6	10	control	control	VERB
73666397v54	6	11	access	access	NOUN
73666397v54	6	12	of	of	ADP
73666397v54	6	13	substrate	substrate	NOUN
73666397v54	6	14	to	to	ADP
73666397v54	6	15	the	the	DET
73666397v54	6	16	active	active	ADJ
73666397v54	6	17	site	site	NOUN
73666397v54	6	18	of	of	ADP
73666397v54	6	19	another	another	DET
73666397v54	6	20	domain	domain	NOUN
73666397v54	6	21	by	by	ADP
73666397v54	6	22	directly	directly	ADV
73666397v54	6	23	blocking	block	VERB
73666397v54	6	24	the	the	DET
73666397v54	6	25	active	active	ADJ
73666397v54	6	26	site	site	NOUN
73666397v54	6	27	or	or	CCONJ
73666397v54	6	28	indirectly	indirectly	ADV
73666397v54	6	29	via	via	ADP
73666397v54	6	30	a	a	DET
73666397v54	6	31	distal	distal	ADJ
73666397v54	6	32	allosteric	allosteric	NOUN
73666397v54	6	33	site	site	NOUN
73666397v54	6	34	.	.	PUNCT
73666397v54	7	1	pin1	pin1	NOUN
73666397v54	7	2	is	be	AUX
73666397v54	7	3	a	a	DET
73666397v54	7	4	model	model	NOUN
73666397v54	7	5	system	system	NOUN
73666397v54	7	6	of	of	ADP
73666397v54	7	7	an	an	DET
73666397v54	7	8	allosteric	allosteric	ADJ
73666397v54	7	9	protein	protein	NOUN
73666397v54	7	10	of	of	ADP
73666397v54	7	11	modular	modular	ADJ
73666397v54	7	12	design	design	NOUN
73666397v54	7	13	which	which	PRON
73666397v54	7	14	consists	consist	VERB
73666397v54	7	15	of	of	ADP
73666397v54	7	16	the	the	DET
73666397v54	7	17	binding	bind	VERB
73666397v54	7	18	ww	ww	PROPN
73666397v54	7	19	domain	domain	NOUN
73666397v54	7	20	that	that	PRON
73666397v54	7	21	is	be	AUX
73666397v54	7	22	flexibly	flexibly	ADV
73666397v54	7	23	tethered	tethered	ADJ
73666397v54	7	24	to	to	ADP
73666397v54	7	25	a	a	DET
73666397v54	7	26	peptidyl	peptidyl	NOUN
73666397v54	7	27	-	-	PUNCT
73666397v54	7	28	prolyl	prolyl	ADJ
73666397v54	7	29	cis	cis	NOUN
73666397v54	7	30	-	-	PUNCT
73666397v54	7	31	trans	trans	NOUN
73666397v54	7	32	isomerase	isomerase	NOUN
73666397v54	7	33	(	(	PUNCT
73666397v54	7	34	ppiase	ppiase	NOUN
73666397v54	7	35	)	)	PUNCT
73666397v54	7	36	domain	domain	NOUN
73666397v54	7	37	.	.	PUNCT
73666397v54	8	1	pin1	pin1	NOUN
73666397v54	8	2	recognizes	recognize	NOUN
73666397v54	8	3	and	and	CCONJ
73666397v54	8	4	catalyses	catalyse	VERB
73666397v54	8	5	the	the	DET
73666397v54	8	6	cis	cis	NOUN
73666397v54	8	7	-	-	PUNCT
73666397v54	8	8	trans	trans	NOUN
73666397v54	8	9	conversion	conversion	NOUN
73666397v54	8	10	of	of	ADP
73666397v54	8	11	the	the	DET
73666397v54	8	12	peptidyl	peptidyl	NOUN
73666397v54	8	13	pser	pser	NOUN
73666397v54	8	14	/	/	SYM
73666397v54	8	15	pthr	pthr	ADJ
73666397v54	8	16	-	-	PUNCT
73666397v54	8	17	pro	pro	ADJ
73666397v54	8	18	bond	bond	NOUN
73666397v54	8	19	of	of	ADP
73666397v54	8	20	many	many	ADJ
73666397v54	8	21	targets	target	NOUN
73666397v54	8	22	.	.	PUNCT
73666397v54	9	1	variations	variation	NOUN
73666397v54	9	2	in	in	ADP
73666397v54	9	3	the	the	DET
73666397v54	9	4	substrate	substrate	NOUN
73666397v54	9	5	'	'	PUNCT
73666397v54	9	6	input	input	NOUN
73666397v54	9	7	'	'	PUNCT
73666397v54	9	8	sequence	sequence	NOUN
73666397v54	9	9	induces	induce	VERB
73666397v54	9	10	differential	differential	ADJ
73666397v54	9	11	processing	processing	NOUN
73666397v54	9	12	by	by	ADP
73666397v54	9	13	pin1	pin1	NOUN
73666397v54	9	14	,	,	PUNCT
73666397v54	9	15	thereby	thereby	ADV
73666397v54	9	16	modulating	modulate	VERB
73666397v54	9	17	the	the	DET
73666397v54	9	18	resultant	resultant	NOUN
73666397v54	9	19	'	'	PUNCT
73666397v54	9	20	output	output	NOUN
73666397v54	9	21	'	'	PUNCT
73666397v54	9	22	activities	activity	NOUN
73666397v54	9	23	for	for	ADP
73666397v54	9	24	binding	bind	VERB
73666397v54	9	25	and/or	and/or	CCONJ
73666397v54	9	26	catalysis	catalysis	NOUN
73666397v54	9	27	.	.	PUNCT
73666397v54	10	1	the	the	DET
73666397v54	10	2	isolated	isolated	ADJ
73666397v54	10	3	domains	domain	NOUN
73666397v54	10	4	only	only	ADV
73666397v54	10	5	hold	hold	VERB
73666397v54	10	6	part	part	NOUN
73666397v54	10	7	of	of	ADP
73666397v54	10	8	the	the	DET
73666397v54	10	9	full	full	ADJ
73666397v54	10	10	activity	activity	NOUN
73666397v54	10	11	that	that	PRON
73666397v54	10	12	is	be	AUX
73666397v54	10	13	observed	observe	VERB
73666397v54	10	14	when	when	SCONJ
73666397v54	10	15	they	they	PRON
73666397v54	10	16	are	be	AUX
73666397v54	10	17	linked	link	VERB
73666397v54	10	18	.	.	PUNCT
73666397v54	11	1	although	although	SCONJ
73666397v54	11	2	the	the	DET
73666397v54	11	3	ww	ww	PROPN
73666397v54	11	4	domain	domain	NOUN
73666397v54	11	5	has	have	VERB
73666397v54	11	6	no	no	DET
73666397v54	11	7	catalytic	catalytic	ADJ
73666397v54	11	8	activity	activity	NOUN
73666397v54	11	9	,	,	PUNCT
73666397v54	11	10	its	its	PRON
73666397v54	11	11	absence	absence	NOUN
73666397v54	11	12	has	have	VERB
73666397v54	11	13	deleterious	deleterious	ADJ
73666397v54	11	14	consequences	consequence	NOUN
73666397v54	11	15	on	on	ADP
73666397v54	11	16	the	the	DET
73666397v54	11	17	catalytic	catalytic	ADJ
73666397v54	11	18	activity	activity	NOUN
73666397v54	11	19	of	of	ADP
73666397v54	11	20	pin1	pin1	NOUN
73666397v54	11	21	.	.	PUNCT
73666397v54	12	1	in	in	ADP
73666397v54	12	2	addition	addition	NOUN
73666397v54	12	3	,	,	PUNCT
73666397v54	12	4	ligand	ligand	NOUN
73666397v54	12	5	interaction	interaction	NOUN
73666397v54	12	6	results	result	NOUN
73666397v54	12	7	in	in	ADP
73666397v54	12	8	inter	inter	ADJ
73666397v54	12	9	-	-	ADJ
73666397v54	12	10	domain	domain	ADJ
73666397v54	12	11	coupling	coupling	NOUN
73666397v54	12	12	.	.	PUNCT
73666397v54	13	1	therefore	therefore	ADV
73666397v54	13	2	,	,	PUNCT
73666397v54	13	3	a	a	DET
73666397v54	13	4	mode	mode	NOUN
73666397v54	13	5	of	of	ADP
73666397v54	13	6	information	information	NOUN
73666397v54	13	7	transformation	transformation	NOUN
73666397v54	13	8	exists	exist	VERB
73666397v54	13	9	that	that	PRON
73666397v54	13	10	qualifies	qualify	VERB
73666397v54	13	11	the	the	DET
73666397v54	13	12	ww	ww	PROPN
73666397v54	13	13	as	as	ADP
73666397v54	13	14	an	an	DET
73666397v54	13	15	allosteric	allosteric	NOUN
73666397v54	13	16	modulator	modulator	NOUN
73666397v54	13	17	of	of	ADP
73666397v54	13	18	the	the	DET
73666397v54	13	19	activity	activity	NOUN
73666397v54	13	20	of	of	ADP
73666397v54	13	21	pin1	pin1	NOUN
73666397v54	13	22	-	-	PUNCT
73666397v54	13	23	ppiase	ppiase	NOUN
73666397v54	13	24	.	.	PUNCT
73666397v54	14	1	the	the	DET
73666397v54	14	2	underlying	underlying	ADJ
73666397v54	14	3	molecular	molecular	ADJ
73666397v54	14	4	processes	process	NOUN
73666397v54	14	5	for	for	ADP
73666397v54	14	6	site	site	NOUN
73666397v54	14	7	to	to	PART
73666397v54	14	8	site	site	VERB
73666397v54	14	9	communication	communication	NOUN
73666397v54	14	10	in	in	ADP
73666397v54	14	11	proteins	protein	NOUN
73666397v54	14	12	are	be	AUX
73666397v54	14	13	thought	think	VERB
73666397v54	14	14	to	to	PART
73666397v54	14	15	involve	involve	VERB
73666397v54	14	16	conformational	conformational	ADJ
73666397v54	14	17	transitions	transition	NOUN
73666397v54	14	18	that	that	PRON
73666397v54	14	19	are	be	AUX
73666397v54	14	20	propagated	propagate	VERB
73666397v54	14	21	between	between	ADP
73666397v54	14	22	the	the	DET
73666397v54	14	23	active	active	ADJ
73666397v54	14	24	site	site	NOUN
73666397v54	14	25	and	and	CCONJ
73666397v54	14	26	the	the	DET
73666397v54	14	27	allosteric	allosteric	NOUN
73666397v54	14	28	site	site	NOUN
73666397v54	14	29	.	.	PUNCT
73666397v54	15	1	the	the	DET
73666397v54	15	2	time	time	NOUN
73666397v54	15	3	scales	scale	NOUN
73666397v54	15	4	for	for	ADP
73666397v54	15	5	such	such	ADJ
73666397v54	15	6	motions	motion	NOUN
73666397v54	15	7	can	can	AUX
73666397v54	15	8	be	be	AUX
73666397v54	15	9	in	in	ADP
73666397v54	15	10	the	the	DET
73666397v54	15	11	order	order	NOUN
73666397v54	15	12	of	of	ADP
73666397v54	15	13	slow	slow	ADJ
73666397v54	15	14	(	(	PUNCT
73666397v54	15	15	ì_å_s	ì_å_s	PROPN
73666397v54	15	16	-	-	PUNCT
73666397v54	15	17	ms	ms	PROPN
73666397v54	15	18	)	)	PUNCT
73666397v54	15	19	displacements	displacement	NOUN
73666397v54	15	20	to	to	PART
73666397v54	15	21	fast	fast	VERB
73666397v54	15	22	(	(	PUNCT
73666397v54	15	23	ps	ps	NOUN
73666397v54	15	24	-	-	PUNCT
73666397v54	15	25	ns	ns	NOUN
73666397v54	15	26	)	)	PUNCT
73666397v54	15	27	fluctuating	fluctuate	VERB
73666397v54	15	28	motions	motion	NOUN
73666397v54	15	29	.	.	PUNCT
73666397v54	16	1	nuclear	nuclear	ADJ
73666397v54	16	2	magnetic	magnetic	ADJ
73666397v54	16	3	resonance	resonance	NOUN
73666397v54	16	4	(	(	PUNCT
73666397v54	16	5	nmr	nmr	NOUN
73666397v54	16	6	)	)	PUNCT
73666397v54	16	7	is	be	AUX
73666397v54	16	8	a	a	DET
73666397v54	16	9	versatile	versatile	ADJ
73666397v54	16	10	non	non	ADJ
73666397v54	16	11	-	-	ADJ
73666397v54	16	12	invasive	invasive	ADJ
73666397v54	16	13	technique	technique	NOUN
73666397v54	16	14	that	that	PRON
73666397v54	16	15	probes	probe	VERB
73666397v54	16	16	such	such	ADJ
73666397v54	16	17	molecular	molecular	ADJ
73666397v54	16	18	dynamics	dynamic	NOUN
73666397v54	16	19	in	in	ADP
73666397v54	16	20	solution	solution	NOUN
73666397v54	16	21	and	and	CCONJ
73666397v54	16	22	at	at	ADP
73666397v54	16	23	multiple	multiple	ADJ
73666397v54	16	24	sites	site	NOUN
73666397v54	16	25	.	.	PUNCT
73666397v54	17	1	this	this	DET
73666397v54	17	2	dissertation	dissertation	NOUN
73666397v54	17	3	reports	report	VERB
73666397v54	17	4	the	the	DET
73666397v54	17	5	research	research	NOUN
73666397v54	17	6	on	on	ADP
73666397v54	17	7	the	the	DET
73666397v54	17	8	discovery	discovery	NOUN
73666397v54	17	9	of	of	ADP
73666397v54	17	10	a	a	DET
73666397v54	17	11	novel	novel	ADJ
73666397v54	17	12	internal	internal	ADJ
73666397v54	17	13	dynamic	dynamic	ADJ
73666397v54	17	14	conduit	conduit	NOUN
73666397v54	17	15	of	of	ADP
73666397v54	17	16	modular	modular	ADJ
73666397v54	17	17	allosteric	allosteric	NOUN
73666397v54	17	18	communication	communication	NOUN
73666397v54	17	19	between	between	ADP
73666397v54	17	20	the	the	DET
73666397v54	17	21	catalytic	catalytic	ADJ
73666397v54	17	22	site	site	NOUN
73666397v54	17	23	of	of	ADP
73666397v54	17	24	pin1	pin1	NOUN
73666397v54	17	25	-	-	PUNCT
73666397v54	17	26	ppiase	ppiase	NOUN
73666397v54	17	27	and	and	CCONJ
73666397v54	17	28	the	the	DET
73666397v54	17	29	allosteric	allosteric	NOUN
73666397v54	17	30	ww	ww	PROPN
73666397v54	17	31	interaction	interaction	NOUN
73666397v54	17	32	site	site	NOUN
73666397v54	17	33	located	locate	VERB
73666397v54	17	34	about	about	ADV
73666397v54	17	35	12	12	NUM
73666397v54	17	36	angstroms	angstrom	NOUN
73666397v54	17	37	away	away	ADV
73666397v54	17	38	.	.	PUNCT
73666397v54	18	1	in	in	ADP
73666397v54	18	2	particular	particular	ADJ
73666397v54	18	3	,	,	PUNCT
73666397v54	18	4	deuterium	deuterium	NOUN
73666397v54	18	5	(	(	PUNCT
73666397v54	18	6	2d	2d	NOUN
73666397v54	18	7	)	)	PUNCT
73666397v54	18	8	nmr	nmr	NOUN
73666397v54	18	9	relaxation	relaxation	NOUN
73666397v54	18	10	experiments	experiment	NOUN
73666397v54	18	11	were	be	AUX
73666397v54	18	12	used	use	VERB
73666397v54	18	13	to	to	PART
73666397v54	18	14	probe	probe	VERB
73666397v54	18	15	the	the	DET
73666397v54	18	16	internal	internal	ADJ
73666397v54	18	17	flexibility	flexibility	NOUN
73666397v54	18	18	of	of	ADP
73666397v54	18	19	methyl	methyl	NOUN
73666397v54	18	20	side	side	NOUN
73666397v54	18	21	chains	chain	NOUN
73666397v54	18	22	of	of	ADP
73666397v54	18	23	pin1	pin1	NOUN
73666397v54	18	24	-	-	PUNCT
73666397v54	18	25	ppiase	ppiase	NOUN
73666397v54	18	26	upon	upon	SCONJ
73666397v54	18	27	ligand	ligand	NOUN
73666397v54	18	28	interaction	interaction	NOUN
73666397v54	18	29	.	.	PUNCT
73666397v54	19	1	ligands	ligand	NOUN
73666397v54	19	2	of	of	ADP
73666397v54	19	3	different	different	ADJ
73666397v54	19	4	chemical	chemical	ADJ
73666397v54	19	5	compositions	composition	NOUN
73666397v54	19	6	,	,	PUNCT
73666397v54	19	7	configurations	configuration	NOUN
73666397v54	19	8	and	and	CCONJ
73666397v54	19	9	flexibilities	flexibility	NOUN
73666397v54	19	10	induced	induce	VERB
73666397v54	19	11	varying	vary	VERB
73666397v54	19	12	rigidification	rigidification	NOUN
73666397v54	19	13	magnitudes	magnitude	NOUN
73666397v54	19	14	of	of	ADP
73666397v54	19	15	pin1	pin1	NOUN
73666397v54	19	16	's	's	PART
73666397v54	19	17	internal	internal	ADJ
73666397v54	19	18	fast	fast	NOUN
73666397v54	19	19	(	(	PUNCT
73666397v54	19	20	ps	ps	NOUN
73666397v54	19	21	-	-	PUNCT
73666397v54	19	22	ns	ns	NOUN
73666397v54	19	23	)	)	PUNCT
73666397v54	19	24	fluctuating	fluctuate	VERB
73666397v54	19	25	motions	motion	NOUN
73666397v54	19	26	.	.	PUNCT
73666397v54	20	1	the	the	DET
73666397v54	20	2	greatest	great	ADJ
73666397v54	20	3	flexibility	flexibility	NOUN
73666397v54	20	4	loss	loss	NOUN
73666397v54	20	5	was	be	AUX
73666397v54	20	6	observed	observe	VERB
73666397v54	20	7	for	for	ADP
73666397v54	20	8	ligands	ligand	NOUN
73666397v54	20	9	with	with	ADP
73666397v54	20	10	high	high	ADJ
73666397v54	20	11	binding	binding	ADJ
73666397v54	20	12	affinities	affinity	NOUN
73666397v54	20	13	.	.	PUNCT
73666397v54	21	1	because	because	SCONJ
73666397v54	21	2	the	the	DET
73666397v54	21	3	locked	lock	VERB
73666397v54	21	4	-	-	PUNCT
73666397v54	21	5	cis	cis	NOUN
73666397v54	21	6	ground	ground	NOUN
73666397v54	21	7	state	state	NOUN
73666397v54	21	8	analog	analog	NOUN
73666397v54	21	9	of	of	ADP
73666397v54	21	10	substrate	substrate	NOUN
73666397v54	21	11	showed	show	VERB
73666397v54	21	12	a	a	DET
73666397v54	21	13	greater	great	ADJ
73666397v54	21	14	response	response	NOUN
73666397v54	21	15	than	than	ADP
73666397v54	21	16	the	the	DET
73666397v54	21	17	trans	trans	PROPN
73666397v54	21	18	counterpart	counterpart	NOUN
73666397v54	21	19	,	,	PUNCT
73666397v54	21	20	the	the	DET
73666397v54	21	21	dynamic	dynamic	ADJ
73666397v54	21	22	conduit	conduit	NOUN
73666397v54	21	23	observed	observe	VERB
73666397v54	21	24	with	with	ADP
73666397v54	21	25	peptide	peptide	NOUN
73666397v54	21	26	substrate	substrate	NOUN
73666397v54	21	27	must	must	AUX
73666397v54	21	28	coordinate	coordinate	VERB
73666397v54	21	29	the	the	DET
73666397v54	21	30	interaction	interaction	NOUN
73666397v54	21	31	of	of	ADP
73666397v54	21	32	cis	cis	NOUN
73666397v54	21	33	-	-	PUNCT
73666397v54	21	34	like	like	ADJ
73666397v54	21	35	substrate	substrate	NOUN
73666397v54	21	36	conformers	conformer	VERB
73666397v54	21	37	.	.	PUNCT
73666397v54	22	1	although	although	SCONJ
73666397v54	22	2	the	the	DET
73666397v54	22	3	cis	cis	NOUN
73666397v54	22	4	-	-	PUNCT
73666397v54	22	5	locked	lock	VERB
73666397v54	22	6	isostere	isostere	NOUN
73666397v54	22	7	does	do	AUX
73666397v54	22	8	not	not	PART
73666397v54	22	9	bind	bind	VERB
73666397v54	22	10	pin1	pin1	NOUN
73666397v54	22	11	-	-	PUNCT
73666397v54	22	12	ww	ww	PROPN
73666397v54	22	13	,	,	PUNCT
73666397v54	22	14	it	it	PRON
73666397v54	22	15	caused	cause	VERB
73666397v54	22	16	a	a	DET
73666397v54	22	17	much	much	ADV
73666397v54	22	18	weaker	weak	ADJ
73666397v54	22	19	response	response	NOUN
73666397v54	22	20	in	in	ADP
73666397v54	22	21	the	the	DET
73666397v54	22	22	internal	internal	ADJ
73666397v54	22	23	conduit	conduit	NOUN
73666397v54	22	24	for	for	ADP
73666397v54	22	25	the	the	DET
73666397v54	22	26	isolated	isolated	ADJ
73666397v54	22	27	ppiase	ppiase	NOUN
73666397v54	22	28	domain	domain	NOUN
73666397v54	22	29	and	and	CCONJ
73666397v54	22	30	bound	bind	VERB
73666397v54	22	31	weakly	weakly	ADJ
73666397v54	22	32	than	than	ADP
73666397v54	22	33	pin1	pin1	NOUN
73666397v54	22	34	-	-	PUNCT
73666397v54	22	35	ppiase	ppiase	NOUN
73666397v54	22	36	.	.	PUNCT
73666397v54	23	1	this	this	PRON
73666397v54	23	2	suggests	suggest	VERB
73666397v54	23	3	that	that	SCONJ
73666397v54	23	4	the	the	DET
73666397v54	23	5	dynamic	dynamic	ADJ
73666397v54	23	6	conduit	conduit	NOUN
73666397v54	23	7	links	link	NOUN
73666397v54	23	8	ligand	ligand	VERB
73666397v54	23	9	binding	bind	VERB
73666397v54	23	10	activity	activity	NOUN
73666397v54	23	11	at	at	ADP
73666397v54	23	12	the	the	DET
73666397v54	23	13	ppiase	ppiase	NOUN
73666397v54	23	14	active	active	ADJ
73666397v54	23	15	site	site	NOUN
73666397v54	23	16	and	and	CCONJ
73666397v54	23	17	the	the	DET
73666397v54	23	18	interaction	interaction	NOUN
73666397v54	23	19	of	of	ADP
73666397v54	23	20	the	the	DET
73666397v54	23	21	ww	ww	PROPN
73666397v54	23	22	domain	domain	NOUN
73666397v54	23	23	at	at	ADP
73666397v54	23	24	the	the	DET
73666397v54	23	25	domain	domain	NOUN
73666397v54	23	26	interface	interface	NOUN
73666397v54	23	27	on	on	ADP
73666397v54	23	28	pin1	pin1	NOUN
73666397v54	23	29	-	-	PUNCT
73666397v54	23	30	ppiase	ppiase	NOUN
73666397v54	23	31	.	.	PUNCT
73666397v54	24	1	in	in	ADP
73666397v54	24	2	addition	addition	NOUN
73666397v54	24	3	to	to	ADP
73666397v54	24	4	probing	probe	VERB
73666397v54	24	5	the	the	DET
73666397v54	24	6	dynamics	dynamic	NOUN
73666397v54	24	7	-	-	PUNCT
73666397v54	24	8	function	function	NOUN
73666397v54	24	9	relationships	relationship	NOUN
73666397v54	24	10	of	of	ADP
73666397v54	24	11	pin1	pin1	NOUN
73666397v54	24	12	,	,	PUNCT
73666397v54	24	13	natural	natural	ADJ
73666397v54	24	14	abundance	abundance	NOUN
73666397v54	24	15	carbon	carbon	NOUN
73666397v54	24	16	(	(	PUNCT
73666397v54	24	17	13cì_å±	13cì_å±	NUM
73666397v54	24	18	)	)	PUNCT
73666397v54	24	19	nmr	nmr	NOUN
73666397v54	24	20	relaxation	relaxation	NOUN
73666397v54	24	21	dispersion	dispersion	NOUN
73666397v54	24	22	experiments	experiment	NOUN
73666397v54	24	23	were	be	AUX
73666397v54	24	24	used	use	VERB
73666397v54	24	25	to	to	PART
73666397v54	24	26	probe	probe	VERB
73666397v54	24	27	the	the	DET
73666397v54	24	28	dynamics	dynamic	NOUN
73666397v54	24	29	of	of	ADP
73666397v54	24	30	the	the	DET
73666397v54	24	31	backbone	backbone	NOUN
73666397v54	24	32	dihedrals	dihedral	NOUN
73666397v54	24	33	of	of	ADP
73666397v54	24	34	a	a	DET
73666397v54	24	35	pin1	pin1	NOUN
73666397v54	24	36	ligand	ligand	NOUN
73666397v54	24	37	system	system	NOUN
73666397v54	24	38	comprised	comprise	VERB
73666397v54	24	39	of	of	ADP
73666397v54	24	40	a	a	DET
73666397v54	24	41	peptide	peptide	NOUN
73666397v54	24	42	substrate	substrate	NOUN
73666397v54	24	43	and	and	CCONJ
73666397v54	24	44	its	its	PRON
73666397v54	24	45	representative	representative	ADJ
73666397v54	24	46	ground	ground	NOUN
73666397v54	24	47	state	state	NOUN
73666397v54	24	48	cis	cis	PROPN
73666397v54	24	49	and	and	CCONJ
73666397v54	24	50	trans	trans	X
73666397v54	24	51	locked	lock	VERB
73666397v54	24	52	analogues	analogue	NOUN
73666397v54	24	53	.	.	PUNCT
73666397v54	25	1	from	from	ADP
73666397v54	25	2	this	this	PRON
73666397v54	25	3	,	,	PUNCT
73666397v54	25	4	newer	new	ADJ
73666397v54	25	5	findings	finding	NOUN
73666397v54	25	6	on	on	ADP
73666397v54	25	7	the	the	DET
73666397v54	25	8	site	site	NOUN
73666397v54	25	9	-	-	PUNCT
73666397v54	25	10	specific	specific	ADJ
73666397v54	25	11	kinetics	kinetic	NOUN
73666397v54	25	12	and	and	CCONJ
73666397v54	25	13	thermodynamics	thermodynamic	NOUN
73666397v54	25	14	of	of	ADP
73666397v54	25	15	the	the	DET
73666397v54	25	16	ppiase	ppiase	NOUN
73666397v54	25	17	rotomerization	rotomerization	NOUN
73666397v54	25	18	mechanism	mechanism	NOUN
73666397v54	25	19	are	be	AUX
73666397v54	25	20	hereby	hereby	ADV
73666397v54	25	21	reported	report	VERB
73666397v54	25	22	.	.	PUNCT
73666397v54	26	1	in	in	ADP
73666397v54	26	2	particular	particular	ADJ
73666397v54	26	3	,	,	PUNCT
73666397v54	26	4	the	the	DET
73666397v54	26	5	cis	cis	NOUN
73666397v54	26	6	conformer	conformer	NOUN
73666397v54	26	7	is	be	AUX
73666397v54	26	8	more	more	ADV
73666397v54	26	9	conformationally	conformationally	ADV
73666397v54	26	10	restricted	restrict	VERB
73666397v54	26	11	and	and	CCONJ
73666397v54	26	12	primed	prime	VERB
73666397v54	26	13	for	for	ADP
73666397v54	26	14	docking	docking	NOUN
73666397v54	26	15	ppiase	ppiase	NOUN
73666397v54	26	16	than	than	SCONJ
73666397v54	26	17	the	the	DET
73666397v54	26	18	trans	trans	PROPN
73666397v54	26	19	counterpart	counterpart	NOUN
73666397v54	26	20	which	which	PRON
73666397v54	26	21	experiences	experience	VERB
73666397v54	26	22	pre	pre	NOUN
73666397v54	26	23	-	-	NOUN
73666397v54	26	24	organization	organization	NOUN
73666397v54	26	25	at	at	ADP
73666397v54	26	26	the	the	DET
73666397v54	26	27	terminal	terminal	NOUN
73666397v54	26	28	ends	end	VERB
73666397v54	26	29	upon	upon	SCONJ
73666397v54	26	30	binding	bind	VERB
73666397v54	26	31	ppiase	ppiase	NOUN
73666397v54	26	32	.	.	PUNCT
73666397v54	27	1	substrate	substrate	NOUN
73666397v54	27	2	isomerization	isomerization	NOUN
73666397v54	27	3	proceeds	proceed	VERB
73666397v54	27	4	with	with	ADP
73666397v54	27	5	anchoring	anchoring	NOUN
73666397v54	27	6	of	of	ADP
73666397v54	27	7	residues	residue	NOUN
73666397v54	27	8	located	locate	VERB
73666397v54	27	9	at	at	ADP
73666397v54	27	10	the	the	DET
73666397v54	27	11	n	n	NOUN
73666397v54	27	12	-	-	NOUN
73666397v54	27	13	terminal	terminal	NOUN
73666397v54	27	14	of	of	ADP
73666397v54	27	15	the	the	DET
73666397v54	27	16	peptidyl	peptidyl	NOUN
73666397v54	27	17	-	-	PUNCT
73666397v54	27	18	prolyl	prolyl	ADJ
73666397v54	27	19	bond	bond	NOUN
73666397v54	27	20	and	and	CCONJ
73666397v54	27	21	rotation	rotation	NOUN
73666397v54	27	22	at	at	ADP
73666397v54	27	23	the	the	DET
73666397v54	27	24	c	c	NOUN
73666397v54	27	25	-	-	PUNCT
73666397v54	27	26	terminal	terminal	ADJ
73666397v54	27	27	end	end	NOUN
73666397v54	27	28	with	with	ADP
73666397v54	27	29	activation	activation	NOUN
73666397v54	27	30	free	free	ADJ
73666397v54	27	31	energies	energy	NOUN
73666397v54	27	32	for	for	ADP
73666397v54	27	33	cis	cis	NOUN
73666397v54	27	34	-	-	PUNCT
73666397v54	27	35	trans	trans	NOUN
73666397v54	27	36	conversion	conversion	NOUN
73666397v54	27	37	of	of	ADP
73666397v54	27	38	ì	ì	PROPN
73666397v54	27	39	_	_	PROPN
73666397v54	27	40	'	'	PUNCT
73666397v54	27	41	gì¢	gì¢	PROPN
73666397v54	27	42	ââåêct	ââåêct	VERB
73666397v54	27	43	13.3	13.3	NUM
73666397v54	27	44	kcal	kcal	PROPN
73666397v54	27	45	/	/	SYM
73666397v54	27	46	mol	mol	PROPN
73666397v54	27	47	and	and	CCONJ
73666397v54	27	48	ì	ì	PROPN
73666397v54	27	49	_	_	PUNCT
73666397v54	27	50	'	'	PUNCT
73666397v54	27	51	gì¢	gì¢	PROPN
73666397v54	28	1	ââåêtc	ââåêtc	VERB
73666397v54	28	2	15.4	15.4	NUM
73666397v54	28	3	kcal	kcal	PROPN
73666397v54	28	4	/	/	SYM
73666397v54	28	5	mol	mol	PROPN
73666397v54	28	6	.	.	PUNCT