id	sid	tid	token	lemma	pos
7p88cf97h8n	1	1	acylnitroso	acylnitroso	PROPN
7p88cf97h8n	1	2	cycloadducts	cycloadduct	NOUN
7p88cf97h8n	1	3	have	have	AUX
7p88cf97h8n	1	4	proven	prove	VERB
7p88cf97h8n	1	5	to	to	PART
7p88cf97h8n	1	6	be	be	AUX
7p88cf97h8n	1	7	valuable	valuable	ADJ
7p88cf97h8n	1	8	intermediates	intermediate	NOUN
7p88cf97h8n	1	9	in	in	ADP
7p88cf97h8n	1	10	the	the	DET
7p88cf97h8n	1	11	syntheses	synthesis	NOUN
7p88cf97h8n	1	12	of	of	ADP
7p88cf97h8n	1	13	a	a	DET
7p88cf97h8n	1	14	plethora	plethora	NOUN
7p88cf97h8n	1	15	of	of	ADP
7p88cf97h8n	1	16	biologically	biologically	ADV
7p88cf97h8n	1	17	active	active	ADJ
7p88cf97h8n	1	18	molecules	molecule	NOUN
7p88cf97h8n	1	19	.	.	PUNCT
7p88cf97h8n	2	1	the	the	DET
7p88cf97h8n	2	2	utility	utility	NOUN
7p88cf97h8n	2	3	of	of	ADP
7p88cf97h8n	2	4	relatively	relatively	ADV
7p88cf97h8n	2	5	simple	simple	ADJ
7p88cf97h8n	2	6	intermediates	intermediate	NOUN
7p88cf97h8n	2	7	arises	arise	VERB
7p88cf97h8n	2	8	from	from	ADP
7p88cf97h8n	2	9	the	the	DET
7p88cf97h8n	2	10	multitude	multitude	NOUN
7p88cf97h8n	2	11	of	of	ADP
7p88cf97h8n	2	12	divergent	divergent	ADJ
7p88cf97h8n	2	13	pathways	pathway	NOUN
7p88cf97h8n	2	14	which	which	PRON
7p88cf97h8n	2	15	can	can	AUX
7p88cf97h8n	2	16	be	be	AUX
7p88cf97h8n	2	17	accessed	access	VERB
7p88cf97h8n	2	18	.	.	PUNCT
7p88cf97h8n	3	1	for	for	ADP
7p88cf97h8n	3	2	many	many	ADJ
7p88cf97h8n	3	3	years	year	NOUN
7p88cf97h8n	3	4	the	the	DET
7p88cf97h8n	3	5	miller	miller	PROPN
7p88cf97h8n	3	6	lab	lab	NOUN
7p88cf97h8n	3	7	has	have	AUX
7p88cf97h8n	3	8	been	be	AUX
7p88cf97h8n	3	9	at	at	ADP
7p88cf97h8n	3	10	the	the	DET
7p88cf97h8n	3	11	forefront	forefront	NOUN
7p88cf97h8n	3	12	in	in	ADP
7p88cf97h8n	3	13	the	the	DET
7p88cf97h8n	3	14	discovery	discovery	NOUN
7p88cf97h8n	3	15	of	of	ADP
7p88cf97h8n	3	16	methodologies	methodology	NOUN
7p88cf97h8n	3	17	by	by	ADP
7p88cf97h8n	3	18	which	which	PRON
7p88cf97h8n	3	19	the	the	DET
7p88cf97h8n	3	20	acylnitroso	acylnitroso	NOUN
7p88cf97h8n	3	21	cycloadduct	cycloadduct	NOUN
7p88cf97h8n	3	22	core	core	NOUN
7p88cf97h8n	3	23	may	may	AUX
7p88cf97h8n	3	24	be	be	AUX
7p88cf97h8n	3	25	modified	modify	VERB
7p88cf97h8n	3	26	.	.	PUNCT
7p88cf97h8n	4	1	recently	recently	ADV
7p88cf97h8n	4	2	,	,	PUNCT
7p88cf97h8n	4	3	organometallic	organometallic	ADJ
7p88cf97h8n	4	4	reagents	reagent	NOUN
7p88cf97h8n	4	5	were	be	AUX
7p88cf97h8n	4	6	shown	show	VERB
7p88cf97h8n	4	7	to	to	PART
7p88cf97h8n	4	8	open	open	VERB
7p88cf97h8n	4	9	bicyclic	bicyclic	NOUN
7p88cf97h8n	4	10	acylnitroso	acylnitroso	NOUN
7p88cf97h8n	4	11	cycloadducts	cycloadduct	NOUN
7p88cf97h8n	4	12	and	and	CCONJ
7p88cf97h8n	4	13	,	,	PUNCT
7p88cf97h8n	4	14	more	more	ADV
7p88cf97h8n	4	15	interestingly	interestingly	ADV
7p88cf97h8n	4	16	,	,	PUNCT
7p88cf97h8n	4	17	the	the	DET
7p88cf97h8n	4	18	prospect	prospect	NOUN
7p88cf97h8n	4	19	of	of	ADP
7p88cf97h8n	4	20	highly	highly	ADV
7p88cf97h8n	4	21	regioselective	regioselective	ADJ
7p88cf97h8n	4	22	openings	opening	NOUN
7p88cf97h8n	4	23	was	be	AUX
7p88cf97h8n	4	24	raised	raise	VERB
7p88cf97h8n	4	25	.	.	PUNCT
7p88cf97h8n	5	1	this	this	DET
7p88cf97h8n	5	2	transformation	transformation	NOUN
7p88cf97h8n	5	3	was	be	AUX
7p88cf97h8n	5	4	employed	employ	VERB
7p88cf97h8n	5	5	in	in	ADP
7p88cf97h8n	5	6	the	the	DET
7p88cf97h8n	5	7	synthesis	synthesis	NOUN
7p88cf97h8n	5	8	of	of	ADP
7p88cf97h8n	5	9	a	a	DET
7p88cf97h8n	5	10	compound	compound	NOUN
7p88cf97h8n	5	11	with	with	ADP
7p88cf97h8n	5	12	the	the	DET
7p88cf97h8n	5	13	expectation	expectation	NOUN
7p88cf97h8n	5	14	of	of	ADP
7p88cf97h8n	5	15	inhibitory	inhibitory	ADJ
7p88cf97h8n	5	16	activity	activity	NOUN
7p88cf97h8n	5	17	against	against	ADP
7p88cf97h8n	5	18	5	5	NUM
7p88cf97h8n	5	19	-	-	PUNCT
7p88cf97h8n	5	20	lipoxygenase	lipoxygenase	NOUN
7p88cf97h8n	5	21	,	,	PUNCT
7p88cf97h8n	5	22	an	an	DET
7p88cf97h8n	5	23	important	important	ADJ
7p88cf97h8n	5	24	mediator	mediator	NOUN
7p88cf97h8n	5	25	of	of	ADP
7p88cf97h8n	5	26	inflammation	inflammation	NOUN
7p88cf97h8n	5	27	intimately	intimately	ADV
7p88cf97h8n	5	28	involved	involve	VERB
7p88cf97h8n	5	29	in	in	ADP
7p88cf97h8n	5	30	a	a	DET
7p88cf97h8n	5	31	number	number	NOUN
7p88cf97h8n	5	32	of	of	ADP
7p88cf97h8n	5	33	disease	disease	NOUN
7p88cf97h8n	5	34	states	state	NOUN
7p88cf97h8n	5	35	including	include	VERB
7p88cf97h8n	5	36	asthma	asthma	NOUN
7p88cf97h8n	5	37	and	and	CCONJ
7p88cf97h8n	5	38	cancer	cancer	NOUN
7p88cf97h8n	5	39	.	.	PUNCT
7p88cf97h8n	6	1	in	in	ADP
7p88cf97h8n	6	2	fact	fact	NOUN
7p88cf97h8n	6	3	,	,	PUNCT
7p88cf97h8n	6	4	the	the	DET
7p88cf97h8n	6	5	compound	compound	NOUN
7p88cf97h8n	6	6	proved	prove	VERB
7p88cf97h8n	6	7	to	to	PART
7p88cf97h8n	6	8	be	be	AUX
7p88cf97h8n	6	9	an	an	DET
7p88cf97h8n	6	10	extremely	extremely	ADV
7p88cf97h8n	6	11	potent	potent	ADJ
7p88cf97h8n	6	12	inhibitor	inhibitor	NOUN
7p88cf97h8n	6	13	(	(	PUNCT
7p88cf97h8n	6	14	ic50	ic50	PROPN
7p88cf97h8n	6	15	51	51	NUM
7p88cf97h8n	6	16	ì_åám	ì_åám	NOUN
7p88cf97h8n	6	17	)	)	PUNCT
7p88cf97h8n	6	18	.	.	PUNCT
7p88cf97h8n	7	1	the	the	DET
7p88cf97h8n	7	2	focus	focus	NOUN
7p88cf97h8n	7	3	of	of	ADP
7p88cf97h8n	7	4	the	the	DET
7p88cf97h8n	7	5	research	research	NOUN
7p88cf97h8n	7	6	described	describe	VERB
7p88cf97h8n	7	7	in	in	ADP
7p88cf97h8n	7	8	this	this	DET
7p88cf97h8n	7	9	work	work	NOUN
7p88cf97h8n	7	10	was	be	AUX
7p88cf97h8n	7	11	to	to	PART
7p88cf97h8n	7	12	expand	expand	VERB
7p88cf97h8n	7	13	upon	upon	SCONJ
7p88cf97h8n	7	14	these	these	DET
7p88cf97h8n	7	15	chemical	chemical	ADJ
7p88cf97h8n	7	16	and	and	CCONJ
7p88cf97h8n	7	17	biological	biological	ADJ
7p88cf97h8n	7	18	discoveries	discovery	NOUN
7p88cf97h8n	7	19	.	.	PUNCT
7p88cf97h8n	8	1	the	the	DET
7p88cf97h8n	8	2	first	first	ADJ
7p88cf97h8n	8	3	issue	issue	NOUN
7p88cf97h8n	8	4	addressed	address	VERB
7p88cf97h8n	8	5	was	be	AUX
7p88cf97h8n	8	6	the	the	DET
7p88cf97h8n	8	7	optimization	optimization	NOUN
7p88cf97h8n	8	8	of	of	ADP
7p88cf97h8n	8	9	the	the	DET
7p88cf97h8n	8	10	copper	copper	NOUN
7p88cf97h8n	8	11	-	-	PUNCT
7p88cf97h8n	8	12	mediated	mediate	VERB
7p88cf97h8n	8	13	organometallic	organometallic	ADJ
7p88cf97h8n	8	14	ring	ring	NOUN
7p88cf97h8n	8	15	opening	opening	NOUN
7p88cf97h8n	8	16	reaction	reaction	NOUN
7p88cf97h8n	8	17	.	.	PUNCT
7p88cf97h8n	9	1	conditions	condition	NOUN
7p88cf97h8n	9	2	which	which	PRON
7p88cf97h8n	9	3	led	lead	VERB
7p88cf97h8n	9	4	to	to	ADP
7p88cf97h8n	9	5	exclusive	exclusive	ADJ
7p88cf97h8n	9	6	&	&	CCONJ
7p88cf97h8n	9	7	gamma;-addition	gamma;-addition	PROPN
7p88cf97h8n	9	8	were	be	AUX
7p88cf97h8n	9	9	discovered	discover	VERB
7p88cf97h8n	9	10	and	and	CCONJ
7p88cf97h8n	9	11	employed	employ	VERB
7p88cf97h8n	9	12	to	to	PART
7p88cf97h8n	9	13	produce	produce	VERB
7p88cf97h8n	9	14	sufficient	sufficient	ADJ
7p88cf97h8n	9	15	material	material	NOUN
7p88cf97h8n	9	16	for	for	ADP
7p88cf97h8n	9	17	derivatization	derivatization	NOUN
7p88cf97h8n	9	18	of	of	ADP
7p88cf97h8n	9	19	the	the	DET
7p88cf97h8n	9	20	core	core	NOUN
7p88cf97h8n	9	21	structure	structure	NOUN
7p88cf97h8n	9	22	.	.	PUNCT
7p88cf97h8n	10	1	interestingly	interestingly	ADV
7p88cf97h8n	10	2	certain	certain	ADJ
7p88cf97h8n	10	3	aspects	aspect	NOUN
7p88cf97h8n	10	4	of	of	ADP
7p88cf97h8n	10	5	the	the	DET
7p88cf97h8n	10	6	optimized	optimize	VERB
7p88cf97h8n	10	7	reaction	reaction	NOUN
7p88cf97h8n	10	8	ran	run	VERB
7p88cf97h8n	10	9	counter	counter	ADV
7p88cf97h8n	10	10	to	to	ADP
7p88cf97h8n	10	11	the	the	DET
7p88cf97h8n	10	12	commonly	commonly	ADV
7p88cf97h8n	10	13	employed	employ	VERB
7p88cf97h8n	10	14	conditions	condition	NOUN
7p88cf97h8n	10	15	for	for	ADP
7p88cf97h8n	10	16	&	&	CCONJ
7p88cf97h8n	10	17	gamma;-selective	gamma;-selective	PROPN
7p88cf97h8n	10	18	copper	copper	NOUN
7p88cf97h8n	10	19	-	-	PUNCT
7p88cf97h8n	10	20	catalyzed	catalyze	VERB
7p88cf97h8n	10	21	allylic	allylic	ADJ
7p88cf97h8n	10	22	addition	addition	NOUN
7p88cf97h8n	10	23	.	.	PUNCT
7p88cf97h8n	11	1	in	in	ADP
7p88cf97h8n	11	2	addition	addition	NOUN
7p88cf97h8n	11	3	,	,	PUNCT
7p88cf97h8n	11	4	with	with	ADP
7p88cf97h8n	11	5	respect	respect	NOUN
7p88cf97h8n	11	6	to	to	ADP
7p88cf97h8n	11	7	biological	biological	ADJ
7p88cf97h8n	11	8	activity	activity	NOUN
7p88cf97h8n	11	9	,	,	PUNCT
7p88cf97h8n	11	10	three	three	NUM
7p88cf97h8n	11	11	sites	site	NOUN
7p88cf97h8n	11	12	on	on	ADP
7p88cf97h8n	11	13	the	the	DET
7p88cf97h8n	11	14	lead	lead	ADJ
7p88cf97h8n	11	15	compound	compound	NOUN
7p88cf97h8n	11	16	were	be	AUX
7p88cf97h8n	11	17	chosen	choose	VERB
7p88cf97h8n	11	18	for	for	ADP
7p88cf97h8n	11	19	derivatization	derivatization	NOUN
7p88cf97h8n	11	20	.	.	PUNCT
7p88cf97h8n	12	1	the	the	DET
7p88cf97h8n	12	2	three	three	NUM
7p88cf97h8n	12	3	sites	site	NOUN
7p88cf97h8n	12	4	,	,	PUNCT
7p88cf97h8n	12	5	deemed	deem	VERB
7p88cf97h8n	12	6	zones	zone	NOUN
7p88cf97h8n	12	7	1	1	NUM
7p88cf97h8n	12	8	,	,	PUNCT
7p88cf97h8n	12	9	2	2	NUM
7p88cf97h8n	12	10	,	,	PUNCT
7p88cf97h8n	12	11	and	and	CCONJ
7p88cf97h8n	12	12	3	3	NUM
7p88cf97h8n	12	13	,	,	PUNCT
7p88cf97h8n	12	14	were	be	AUX
7p88cf97h8n	12	15	the	the	DET
7p88cf97h8n	12	16	iron	iron	NOUN
7p88cf97h8n	12	17	binding	bind	VERB
7p88cf97h8n	12	18	group	group	NOUN
7p88cf97h8n	12	19	,	,	PUNCT
7p88cf97h8n	12	20	the	the	DET
7p88cf97h8n	12	21	diaryl	diaryl	PROPN
7p88cf97h8n	12	22	ether	ether	NOUN
7p88cf97h8n	12	23	,	,	PUNCT
7p88cf97h8n	12	24	and	and	CCONJ
7p88cf97h8n	12	25	the	the	DET
7p88cf97h8n	12	26	cyclopentene	cyclopentene	ADJ
7p88cf97h8n	12	27	core	core	NOUN
7p88cf97h8n	12	28	,	,	PUNCT
7p88cf97h8n	12	29	respectively	respectively	ADV
7p88cf97h8n	12	30	.	.	PUNCT
7p88cf97h8n	13	1	zone	zone	PROPN
7p88cf97h8n	13	2	1	1	NUM
7p88cf97h8n	13	3	was	be	AUX
7p88cf97h8n	13	4	addressed	address	VERB
7p88cf97h8n	13	5	first	first	ADV
7p88cf97h8n	13	6	and	and	CCONJ
7p88cf97h8n	13	7	synthesis	synthesis	NOUN
7p88cf97h8n	13	8	of	of	ADP
7p88cf97h8n	13	9	a	a	DET
7p88cf97h8n	13	10	number	number	NOUN
7p88cf97h8n	13	11	of	of	ADP
7p88cf97h8n	13	12	derivatives	derivative	NOUN
7p88cf97h8n	13	13	with	with	ADP
7p88cf97h8n	13	14	varying	vary	VERB
7p88cf97h8n	13	15	affinity	affinity	NOUN
7p88cf97h8n	13	16	for	for	ADP
7p88cf97h8n	13	17	metal	metal	NOUN
7p88cf97h8n	13	18	binding	binding	NOUN
7p88cf97h8n	13	19	as	as	ADV
7p88cf97h8n	13	20	well	well	ADV
7p88cf97h8n	13	21	as	as	ADP
7p88cf97h8n	13	22	pendant	pendant	ADJ
7p88cf97h8n	13	23	groups	group	NOUN
7p88cf97h8n	13	24	in	in	ADP
7p88cf97h8n	13	25	a	a	DET
7p88cf97h8n	13	26	range	range	NOUN
7p88cf97h8n	13	27	of	of	ADP
7p88cf97h8n	13	28	sizes	size	NOUN
7p88cf97h8n	13	29	was	be	AUX
7p88cf97h8n	13	30	accomplished	accomplish	VERB
7p88cf97h8n	13	31	.	.	PUNCT
7p88cf97h8n	14	1	additionally	additionally	ADV
7p88cf97h8n	14	2	,	,	PUNCT
7p88cf97h8n	14	3	a	a	DET
7p88cf97h8n	14	4	transcarbamoylation	transcarbamoylation	NOUN
7p88cf97h8n	14	5	reaction	reaction	NOUN
7p88cf97h8n	14	6	was	be	AUX
7p88cf97h8n	14	7	discovered	discover	VERB
7p88cf97h8n	14	8	which	which	PRON
7p88cf97h8n	14	9	allowed	allow	VERB
7p88cf97h8n	14	10	the	the	DET
7p88cf97h8n	14	11	t	t	PROPN
7p88cf97h8n	14	12	-	-	PUNCT
7p88cf97h8n	14	13	butyl	butyl	PROPN
7p88cf97h8n	14	14	n	n	PROPN
7p88cf97h8n	14	15	-	-	NOUN
7p88cf97h8n	14	16	hydroxycarbamates	hydroxycarbamate	NOUN
7p88cf97h8n	14	17	to	to	PART
7p88cf97h8n	14	18	be	be	AUX
7p88cf97h8n	14	19	converted	convert	VERB
7p88cf97h8n	14	20	to	to	ADP
7p88cf97h8n	14	21	methyl	methyl	NOUN
7p88cf97h8n	14	22	n	n	NOUN
7p88cf97h8n	14	23	-	-	NOUN
7p88cf97h8n	14	24	hydroxycarbamates	hydroxycarbamate	NOUN
7p88cf97h8n	14	25	in	in	ADP
7p88cf97h8n	14	26	one	one	NUM
7p88cf97h8n	14	27	high	high	ADJ
7p88cf97h8n	14	28	yielding	yielding	NOUN
7p88cf97h8n	14	29	step	step	NOUN
7p88cf97h8n	14	30	.	.	PUNCT
7p88cf97h8n	15	1	exploration	exploration	NOUN
7p88cf97h8n	15	2	of	of	ADP
7p88cf97h8n	15	3	zone	zone	NOUN
7p88cf97h8n	15	4	2	2	NUM
7p88cf97h8n	15	5	was	be	AUX
7p88cf97h8n	15	6	initially	initially	ADV
7p88cf97h8n	15	7	envisioned	envision	VERB
7p88cf97h8n	15	8	to	to	PART
7p88cf97h8n	15	9	proceed	proceed	VERB
7p88cf97h8n	15	10	through	through	ADP
7p88cf97h8n	15	11	an	an	DET
7p88cf97h8n	15	12	aryl	aryl	ADJ
7p88cf97h8n	15	13	halide	halide	NOUN
7p88cf97h8n	15	14	intermediate	intermediate	ADJ
7p88cf97h8n	15	15	which	which	PRON
7p88cf97h8n	15	16	,	,	PUNCT
7p88cf97h8n	15	17	via	via	ADP
7p88cf97h8n	15	18	palladium	palladium	NOUN
7p88cf97h8n	15	19	-	-	PUNCT
7p88cf97h8n	15	20	catalyzed	catalyzed	ADJ
7p88cf97h8n	15	21	coupling	coupling	NOUN
7p88cf97h8n	15	22	,	,	PUNCT
7p88cf97h8n	15	23	would	would	AUX
7p88cf97h8n	15	24	provide	provide	VERB
7p88cf97h8n	15	25	the	the	DET
7p88cf97h8n	15	26	desired	desire	VERB
7p88cf97h8n	15	27	substituted	substituted	ADJ
7p88cf97h8n	15	28	diaryl	diaryl	PROPN
7p88cf97h8n	15	29	ethers	ether	NOUN
7p88cf97h8n	15	30	.	.	PUNCT
7p88cf97h8n	16	1	the	the	DET
7p88cf97h8n	16	2	problematic	problematic	ADJ
7p88cf97h8n	16	3	synthesis	synthesis	NOUN
7p88cf97h8n	16	4	of	of	ADP
7p88cf97h8n	16	5	the	the	DET
7p88cf97h8n	16	6	aryl	aryl	PROPN
7p88cf97h8n	16	7	halide	halide	NOUN
7p88cf97h8n	16	8	intermediate	intermediate	NOUN
7p88cf97h8n	16	9	coupled	couple	VERB
7p88cf97h8n	16	10	with	with	ADP
7p88cf97h8n	16	11	difficulties	difficulty	NOUN
7p88cf97h8n	16	12	associated	associate	VERB
7p88cf97h8n	16	13	with	with	ADP
7p88cf97h8n	16	14	the	the	DET
7p88cf97h8n	16	15	palladium	palladium	NOUN
7p88cf97h8n	16	16	-	-	PUNCT
7p88cf97h8n	16	17	catalyzed	catalyze	VERB
7p88cf97h8n	16	18	reaction	reaction	NOUN
7p88cf97h8n	16	19	ultimately	ultimately	ADV
7p88cf97h8n	16	20	led	lead	VERB
7p88cf97h8n	16	21	to	to	ADP
7p88cf97h8n	16	22	abandonment	abandonment	NOUN
7p88cf97h8n	16	23	of	of	ADP
7p88cf97h8n	16	24	this	this	DET
7p88cf97h8n	16	25	route	route	NOUN
7p88cf97h8n	16	26	.	.	PUNCT
7p88cf97h8n	17	1	an	an	DET
7p88cf97h8n	17	2	alternative	alternative	ADJ
7p88cf97h8n	17	3	route	route	NOUN
7p88cf97h8n	17	4	employing	employ	VERB
7p88cf97h8n	17	5	copper	copper	NOUN
7p88cf97h8n	17	6	-	-	PUNCT
7p88cf97h8n	17	7	mediated	mediate	VERB
7p88cf97h8n	17	8	coupling	coupling	NOUN
7p88cf97h8n	17	9	of	of	ADP
7p88cf97h8n	17	10	phenols	phenol	NOUN
7p88cf97h8n	17	11	and	and	CCONJ
7p88cf97h8n	17	12	arylboronic	arylboronic	ADJ
7p88cf97h8n	17	13	acids	acid	NOUN
7p88cf97h8n	17	14	was	be	AUX
7p88cf97h8n	17	15	designed	design	VERB
7p88cf97h8n	17	16	,	,	PUNCT
7p88cf97h8n	17	17	executed	execute	VERB
7p88cf97h8n	17	18	effectively	effectively	ADV
7p88cf97h8n	17	19	,	,	PUNCT
7p88cf97h8n	17	20	and	and	CCONJ
7p88cf97h8n	17	21	,	,	PUNCT
7p88cf97h8n	17	22	after	after	ADP
7p88cf97h8n	17	23	modification	modification	NOUN
7p88cf97h8n	17	24	of	of	ADP
7p88cf97h8n	17	25	the	the	DET
7p88cf97h8n	17	26	protecting	protect	VERB
7p88cf97h8n	17	27	group	group	NOUN
7p88cf97h8n	17	28	strategy	strategy	NOUN
7p88cf97h8n	17	29	,	,	PUNCT
7p88cf97h8n	17	30	provided	provide	VERB
7p88cf97h8n	17	31	a	a	DET
7p88cf97h8n	17	32	set	set	NOUN
7p88cf97h8n	17	33	of	of	ADP
7p88cf97h8n	17	34	analogues	analogue	NOUN
7p88cf97h8n	17	35	suitable	suitable	ADJ
7p88cf97h8n	17	36	for	for	ADP
7p88cf97h8n	17	37	the	the	DET
7p88cf97h8n	17	38	exploration	exploration	NOUN
7p88cf97h8n	17	39	of	of	ADP
7p88cf97h8n	17	40	zone	zone	NOUN
7p88cf97h8n	17	41	2	2	NUM
7p88cf97h8n	17	42	.	.	PUNCT
7p88cf97h8n	18	1	synthetic	synthetic	ADJ
7p88cf97h8n	18	2	work	work	NOUN
7p88cf97h8n	18	3	on	on	ADP
7p88cf97h8n	18	4	zone	zone	NOUN
7p88cf97h8n	18	5	3	3	NUM
7p88cf97h8n	18	6	derivatives	derivative	NOUN
7p88cf97h8n	18	7	was	be	AUX
7p88cf97h8n	18	8	limited	limit	VERB
7p88cf97h8n	18	9	and	and	CCONJ
7p88cf97h8n	18	10	although	although	SCONJ
7p88cf97h8n	18	11	met	meet	VERB
7p88cf97h8n	18	12	with	with	ADP
7p88cf97h8n	18	13	some	some	DET
7p88cf97h8n	18	14	success	success	NOUN
7p88cf97h8n	18	15	was	be	AUX
7p88cf97h8n	18	16	not	not	PART
7p88cf97h8n	18	17	expanded	expand	VERB
7p88cf97h8n	18	18	upon	upon	SCONJ
7p88cf97h8n	18	19	.	.	PUNCT
7p88cf97h8n	19	1	allylic	allylic	ADJ
7p88cf97h8n	19	2	oxidations	oxidation	NOUN
7p88cf97h8n	19	3	of	of	ADP
7p88cf97h8n	19	4	the	the	DET
7p88cf97h8n	19	5	lead	lead	ADJ
7p88cf97h8n	19	6	structure	structure	NOUN
7p88cf97h8n	19	7	were	be	AUX
7p88cf97h8n	19	8	attempted	attempt	VERB
7p88cf97h8n	19	9	with	with	ADP
7p88cf97h8n	19	10	numerous	numerous	ADJ
7p88cf97h8n	19	11	established	establish	VERB
7p88cf97h8n	19	12	reagents	reagent	NOUN
7p88cf97h8n	19	13	and	and	CCONJ
7p88cf97h8n	19	14	conditions	condition	NOUN
7p88cf97h8n	19	15	and	and	CCONJ
7p88cf97h8n	19	16	in	in	ADP
7p88cf97h8n	19	17	all	all	DET
7p88cf97h8n	19	18	cases	case	NOUN
7p88cf97h8n	19	19	failed	fail	VERB
7p88cf97h8n	19	20	to	to	PART
7p88cf97h8n	19	21	provide	provide	VERB
7p88cf97h8n	19	22	a	a	DET
7p88cf97h8n	19	23	useful	useful	ADJ
7p88cf97h8n	19	24	intermediate	intermediate	NOUN
7p88cf97h8n	19	25	.	.	PUNCT
7p88cf97h8n	20	1	hydroboration	hydroboration	NOUN
7p88cf97h8n	20	2	of	of	ADP
7p88cf97h8n	20	3	the	the	DET
7p88cf97h8n	20	4	cyclopentene	cyclopentene	PROPN
7p88cf97h8n	20	5	core	core	NOUN
7p88cf97h8n	20	6	successfully	successfully	ADV
7p88cf97h8n	20	7	provided	provide	VERB
7p88cf97h8n	20	8	ketones	ketone	NOUN
7p88cf97h8n	20	9	after	after	ADP
7p88cf97h8n	20	10	oxidation	oxidation	NOUN
7p88cf97h8n	20	11	.	.	PUNCT
7p88cf97h8n	21	1	further	further	ADJ
7p88cf97h8n	21	2	exploration	exploration	NOUN
7p88cf97h8n	21	3	of	of	ADP
7p88cf97h8n	21	4	this	this	DET
7p88cf97h8n	21	5	route	route	NOUN
7p88cf97h8n	21	6	was	be	AUX
7p88cf97h8n	21	7	limited	limited	ADJ
7p88cf97h8n	21	8	and	and	CCONJ
7p88cf97h8n	21	9	,	,	PUNCT
7p88cf97h8n	21	10	while	while	SCONJ
7p88cf97h8n	21	11	unsuccessful	unsuccessful	ADJ
7p88cf97h8n	21	12	,	,	PUNCT
7p88cf97h8n	21	13	opportunity	opportunity	NOUN
7p88cf97h8n	21	14	still	still	ADV
7p88cf97h8n	21	15	exists	exist	VERB
7p88cf97h8n	21	16	for	for	ADP
7p88cf97h8n	21	17	derivatization	derivatization	NOUN
7p88cf97h8n	21	18	via	via	ADP
7p88cf97h8n	21	19	this	this	DET
7p88cf97h8n	21	20	route	route	NOUN
7p88cf97h8n	21	21	.	.	PUNCT
7p88cf97h8n	22	1	a	a	DET
7p88cf97h8n	22	2	final	final	ADJ
7p88cf97h8n	22	3	route	route	NOUN
7p88cf97h8n	22	4	employing	employ	VERB
7p88cf97h8n	22	5	the	the	DET
7p88cf97h8n	22	6	aminocyclopentenol	aminocyclopentenol	NOUN
7p88cf97h8n	22	7	from	from	ADP
7p88cf97h8n	22	8	n	n	PROPN
7p88cf97h8n	22	9	-	-	PUNCT
7p88cf97h8n	22	10	o	o	NOUN
7p88cf97h8n	22	11	bond	bond	NOUN
7p88cf97h8n	22	12	reduction	reduction	NOUN
7p88cf97h8n	22	13	of	of	ADP
7p88cf97h8n	22	14	the	the	DET
7p88cf97h8n	22	15	acylnitroso	acylnitroso	NOUN
7p88cf97h8n	22	16	cycloadduct	cycloadduct	NOUN
7p88cf97h8n	22	17	was	be	AUX
7p88cf97h8n	22	18	unsuccessfully	unsuccessfully	ADV
7p88cf97h8n	22	19	explored	explore	VERB
7p88cf97h8n	22	20	.	.	PUNCT
7p88cf97h8n	23	1	biological	biological	ADJ
7p88cf97h8n	23	2	evaluation	evaluation	NOUN
7p88cf97h8n	23	3	of	of	ADP
7p88cf97h8n	23	4	the	the	DET
7p88cf97h8n	23	5	analogues	analogue	NOUN
7p88cf97h8n	23	6	was	be	AUX
7p88cf97h8n	23	7	undertaken	undertake	VERB
7p88cf97h8n	23	8	first	first	ADV
7p88cf97h8n	23	9	through	through	ADP
7p88cf97h8n	23	10	the	the	DET
7p88cf97h8n	23	11	implementation	implementation	NOUN
7p88cf97h8n	23	12	of	of	ADP
7p88cf97h8n	23	13	an	an	DET
7p88cf97h8n	23	14	in	in	ADP
7p88cf97h8n	23	15	-	-	PUNCT
7p88cf97h8n	23	16	house	house	NOUN
7p88cf97h8n	23	17	biochemical	biochemical	ADJ
7p88cf97h8n	23	18	assay	assay	PROPN
7p88cf97h8n	23	19	.	.	PUNCT
7p88cf97h8n	24	1	the	the	DET
7p88cf97h8n	24	2	instability	instability	NOUN
7p88cf97h8n	24	3	of	of	ADP
7p88cf97h8n	24	4	the	the	DET
7p88cf97h8n	24	5	5	5	NUM
7p88cf97h8n	24	6	-	-	PUNCT
7p88cf97h8n	24	7	lipoxygenase	lipoxygenase	NOUN
7p88cf97h8n	24	8	enzyme	enzyme	NOUN
7p88cf97h8n	24	9	along	along	ADV
7p88cf97h8n	24	10	with	with	ADP
7p88cf97h8n	24	11	potential	potential	ADJ
7p88cf97h8n	24	12	interference	interference	NOUN
7p88cf97h8n	24	13	of	of	ADP
7p88cf97h8n	24	14	the	the	DET
7p88cf97h8n	24	15	inhibitors	inhibitor	NOUN
7p88cf97h8n	24	16	with	with	ADP
7p88cf97h8n	24	17	the	the	DET
7p88cf97h8n	24	18	developing	develop	VERB
7p88cf97h8n	24	19	reagent	reagent	NOUN
7p88cf97h8n	24	20	necessitated	necessitate	VERB
7p88cf97h8n	24	21	an	an	DET
7p88cf97h8n	24	22	alternative	alternative	ADJ
7p88cf97h8n	24	23	evaluation	evaluation	NOUN
7p88cf97h8n	24	24	procedure	procedure	NOUN
7p88cf97h8n	24	25	.	.	PUNCT
7p88cf97h8n	25	1	through	through	ADP
7p88cf97h8n	25	2	a	a	DET
7p88cf97h8n	25	3	collaboration	collaboration	NOUN
7p88cf97h8n	25	4	several	several	ADJ
7p88cf97h8n	25	5	zone	zone	NOUN
7p88cf97h8n	25	6	1	1	NUM
7p88cf97h8n	25	7	analogues	analogue	NOUN
7p88cf97h8n	25	8	were	be	AUX
7p88cf97h8n	25	9	tested	test	VERB
7p88cf97h8n	25	10	in	in	ADP
7p88cf97h8n	25	11	a	a	DET
7p88cf97h8n	25	12	whole	whole	ADJ
7p88cf97h8n	25	13	cell	cell	NOUN
7p88cf97h8n	25	14	assay	assay	NOUN
7p88cf97h8n	25	15	and	and	CCONJ
7p88cf97h8n	25	16	,	,	PUNCT
7p88cf97h8n	25	17	while	while	SCONJ
7p88cf97h8n	25	18	specific	specific	ADJ
7p88cf97h8n	25	19	ic50s	ic50	NOUN
7p88cf97h8n	25	20	were	be	AUX
7p88cf97h8n	25	21	not	not	PART
7p88cf97h8n	25	22	determined	determined	ADJ
7p88cf97h8n	25	23	,	,	PUNCT
7p88cf97h8n	25	24	very	very	ADV
7p88cf97h8n	25	25	interesting	interesting	ADJ
7p88cf97h8n	25	26	results	result	NOUN
7p88cf97h8n	25	27	were	be	AUX
7p88cf97h8n	25	28	obtained	obtain	VERB
7p88cf97h8n	25	29	.	.	PUNCT
7p88cf97h8n	26	1	the	the	DET
7p88cf97h8n	26	2	assay	assay	PROPN
7p88cf97h8n	26	3	revealed	reveal	VERB
7p88cf97h8n	26	4	a	a	DET
7p88cf97h8n	26	5	subset	subset	NOUN
7p88cf97h8n	26	6	of	of	ADP
7p88cf97h8n	26	7	the	the	DET
7p88cf97h8n	26	8	compounds	compound	NOUN
7p88cf97h8n	26	9	to	to	PART
7p88cf97h8n	26	10	be	be	AUX
7p88cf97h8n	26	11	inhibitors	inhibitor	NOUN
7p88cf97h8n	26	12	of	of	ADP
7p88cf97h8n	26	13	enzyme	enzyme	NOUN
7p88cf97h8n	26	14	translocation	translocation	NOUN
7p88cf97h8n	26	15	,	,	PUNCT
7p88cf97h8n	26	16	a	a	DET
7p88cf97h8n	26	17	mode	mode	NOUN
7p88cf97h8n	26	18	of	of	ADP
7p88cf97h8n	26	19	action	action	NOUN
7p88cf97h8n	26	20	not	not	PART
7p88cf97h8n	26	21	previously	previously	ADV
7p88cf97h8n	26	22	known	know	VERB
7p88cf97h8n	26	23	and	and	CCONJ
7p88cf97h8n	26	24	,	,	PUNCT
7p88cf97h8n	26	25	potentially	potentially	ADV
7p88cf97h8n	26	26	,	,	PUNCT
7p88cf97h8n	26	27	extremely	extremely	ADV
7p88cf97h8n	26	28	important	important	ADJ
7p88cf97h8n	26	29	for	for	ADP
7p88cf97h8n	26	30	better	well	ADJ
7p88cf97h8n	26	31	understanding	understanding	NOUN
7p88cf97h8n	26	32	of	of	ADP
7p88cf97h8n	26	33	the	the	DET
7p88cf97h8n	26	34	enzyme	enzyme	NOUN
7p88cf97h8n	26	35	and	and	CCONJ
7p88cf97h8n	26	36	inhibitor	inhibitor	NOUN
7p88cf97h8n	26	37	development	development	NOUN
7p88cf97h8n	26	38	.	.	PUNCT
7p88cf97h8n	27	1	additionally	additionally	ADV
7p88cf97h8n	27	2	,	,	PUNCT
7p88cf97h8n	27	3	the	the	DET
7p88cf97h8n	27	4	lead	lead	ADJ
7p88cf97h8n	27	5	compound	compound	NOUN
7p88cf97h8n	27	6	was	be	AUX
7p88cf97h8n	27	7	tested	test	VERB
7p88cf97h8n	27	8	in	in	ADP
7p88cf97h8n	27	9	vivo	vivo	NOUN
7p88cf97h8n	27	10	in	in	ADP
7p88cf97h8n	27	11	an	an	DET
7p88cf97h8n	27	12	established	establish	VERB
7p88cf97h8n	27	13	colon	colon	NOUN
7p88cf97h8n	27	14	cancer	cancer	NOUN
7p88cf97h8n	27	15	model	model	NOUN
7p88cf97h8n	27	16	and	and	CCONJ
7p88cf97h8n	27	17	showed	show	VERB
7p88cf97h8n	27	18	very	very	ADV
7p88cf97h8n	27	19	encouraging	encouraging	ADJ
7p88cf97h8n	27	20	anti	anti	ADJ
7p88cf97h8n	27	21	-	-	ADJ
7p88cf97h8n	27	22	tumorogenic	tumorogenic	ADJ
7p88cf97h8n	27	23	properties	property	NOUN
7p88cf97h8n	27	24	.	.	PUNCT