id sid tid token lemma pos 8p58pc3099m 1 1 saccharides saccharide NOUN 8p58pc3099m 1 2 are be AUX 8p58pc3099m 1 3 arguably arguably ADV 8p58pc3099m 1 4 the the DET 8p58pc3099m 1 5 most most ADV 8p58pc3099m 1 6 talented talented ADJ 8p58pc3099m 1 7 molecules molecule NOUN 8p58pc3099m 1 8 in in ADP 8p58pc3099m 1 9 the the DET 8p58pc3099m 1 10 biological biological ADJ 8p58pc3099m 1 11 repertoire repertoire NOUN 8p58pc3099m 1 12 of of ADP 8p58pc3099m 1 13 molecular molecular ADJ 8p58pc3099m 1 14 structures structure NOUN 8p58pc3099m 1 15 . . PUNCT 8p58pc3099m 2 1 however however ADV 8p58pc3099m 2 2 , , PUNCT 8p58pc3099m 2 3 the the DET 8p58pc3099m 2 4 code code NOUN 8p58pc3099m 2 5 correlating correlating NOUN 8p58pc3099m 2 6 complex complex ADJ 8p58pc3099m 2 7 saccharide saccharide NOUN 8p58pc3099m 2 8 structure structure NOUN 8p58pc3099m 2 9 with with ADP 8p58pc3099m 2 10 biological biological ADJ 8p58pc3099m 2 11 function function NOUN 8p58pc3099m 2 12 remains remain VERB 8p58pc3099m 2 13 elusive elusive ADJ 8p58pc3099m 2 14 . . PUNCT 8p58pc3099m 3 1 the the DET 8p58pc3099m 3 2 saccharide saccharide NOUN 8p58pc3099m 3 3 code code NOUN 8p58pc3099m 3 4 may may AUX 8p58pc3099m 3 5 involve involve VERB 8p58pc3099m 3 6 more more ADV 8p58pc3099m 3 7 subtle subtle ADJ 8p58pc3099m 3 8 physical physical ADJ 8p58pc3099m 3 9 principles principle NOUN 8p58pc3099m 3 10 involving involve VERB 8p58pc3099m 3 11 hydration hydration NOUN 8p58pc3099m 3 12 and and CCONJ 8p58pc3099m 3 13 dynamics dynamic NOUN 8p58pc3099m 3 14 , , PUNCT 8p58pc3099m 3 15 since since SCONJ 8p58pc3099m 3 16 saccharide saccharide ADJ 8p58pc3099m 3 17 oligomers oligomer NOUN 8p58pc3099m 3 18 are be AUX 8p58pc3099m 3 19 commonly commonly ADV 8p58pc3099m 3 20 considered consider VERB 8p58pc3099m 3 21 conformationally conformationally ADV 8p58pc3099m 3 22 flexible flexible ADJ 8p58pc3099m 3 23 structures structure NOUN 8p58pc3099m 3 24 , , PUNCT 8p58pc3099m 3 25 especially especially ADV 8p58pc3099m 3 26 with with ADP 8p58pc3099m 3 27 regard regard NOUN 8p58pc3099m 3 28 to to ADP 8p58pc3099m 3 29 the the DET 8p58pc3099m 3 30 glycosidic glycosidic ADJ 8p58pc3099m 3 31 bonds bond NOUN 8p58pc3099m 3 32 involved involve VERB 8p58pc3099m 3 33 in in ADP 8p58pc3099m 3 34 their their PRON 8p58pc3099m 3 35 assembly assembly NOUN 8p58pc3099m 3 36 . . PUNCT 8p58pc3099m 4 1 to to ADP 8p58pc3099m 4 2 date date NOUN 8p58pc3099m 4 3 , , PUNCT 8p58pc3099m 4 4 no no DET 8p58pc3099m 4 5 clear clear ADJ 8p58pc3099m 4 6 set set NOUN 8p58pc3099m 4 7 of of ADP 8p58pc3099m 4 8 rules rule NOUN 8p58pc3099m 4 9 has have AUX 8p58pc3099m 4 10 been be AUX 8p58pc3099m 4 11 developed develop VERB 8p58pc3099m 4 12 that that PRON 8p58pc3099m 4 13 correlates correlate VERB 8p58pc3099m 4 14 oligosaccharide oligosaccharide NOUN 8p58pc3099m 4 15 primary primary ADJ 8p58pc3099m 4 16 structure structure NOUN 8p58pc3099m 4 17 with with ADP 8p58pc3099m 4 18 conformational conformational ADJ 8p58pc3099m 4 19 preference preference NOUN 8p58pc3099m 4 20 and and CCONJ 8p58pc3099m 4 21 dynamic dynamic ADJ 8p58pc3099m 4 22 properties property NOUN 8p58pc3099m 4 23 . . PUNCT 8p58pc3099m 5 1 a a DET 8p58pc3099m 5 2 large large ADJ 8p58pc3099m 5 3 component component NOUN 8p58pc3099m 5 4 of of ADP 8p58pc3099m 5 5 this this DET 8p58pc3099m 5 6 work work NOUN 8p58pc3099m 5 7 involved involve VERB 8p58pc3099m 5 8 developing develop VERB 8p58pc3099m 5 9 experimental experimental ADJ 8p58pc3099m 5 10 and and CCONJ 8p58pc3099m 5 11 theoretical theoretical ADJ 8p58pc3099m 5 12 methods method NOUN 8p58pc3099m 5 13 to to PART 8p58pc3099m 5 14 prepare prepare VERB 8p58pc3099m 5 15 biologically biologically ADV 8p58pc3099m 5 16 important important ADJ 8p58pc3099m 5 17 oligosaccharides oligosaccharide NOUN 8p58pc3099m 5 18 with with ADP 8p58pc3099m 5 19 isotopic isotopic ADJ 8p58pc3099m 5 20 enrichment enrichment NOUN 8p58pc3099m 5 21 and and CCONJ 8p58pc3099m 5 22 to to PART 8p58pc3099m 5 23 study study VERB 8p58pc3099m 5 24 their their PRON 8p58pc3099m 5 25 solution solution NOUN 8p58pc3099m 5 26 properties property NOUN 8p58pc3099m 5 27 . . PUNCT 8p58pc3099m 6 1 the the DET 8p58pc3099m 6 2 use use NOUN 8p58pc3099m 6 3 of of ADP 8p58pc3099m 6 4 isotopically isotopically ADV 8p58pc3099m 6 5 labeled label VERB 8p58pc3099m 6 6 monosaccharide monosaccharide NOUN 8p58pc3099m 6 7 precursors precursor NOUN 8p58pc3099m 6 8 dramatically dramatically ADV 8p58pc3099m 6 9 increases increase VERB 8p58pc3099m 6 10 the the DET 8p58pc3099m 6 11 information information NOUN 8p58pc3099m 6 12 content content NOUN 8p58pc3099m 6 13 of of ADP 8p58pc3099m 6 14 structural structural ADJ 8p58pc3099m 6 15 studies study NOUN 8p58pc3099m 6 16 of of ADP 8p58pc3099m 6 17 monoand monoand PROPN 8p58pc3099m 6 18 oligosaccharides oligosaccharide NOUN 8p58pc3099m 6 19 . . PUNCT 8p58pc3099m 7 1 detailed detailed ADJ 8p58pc3099m 7 2 structural structural ADJ 8p58pc3099m 7 3 studies study NOUN 8p58pc3099m 7 4 of of ADP 8p58pc3099m 7 5 oligosaccharides oligosaccharide NOUN 8p58pc3099m 7 6 are be AUX 8p58pc3099m 7 7 best well ADV 8p58pc3099m 7 8 conducted conduct VERB 8p58pc3099m 7 9 by by ADP 8p58pc3099m 7 10 experimental experimental ADJ 8p58pc3099m 7 11 methods method NOUN 8p58pc3099m 7 12 involving involve VERB 8p58pc3099m 7 13 the the DET 8p58pc3099m 7 14 use use NOUN 8p58pc3099m 7 15 of of ADP 8p58pc3099m 7 16 aqueous aqueous ADJ 8p58pc3099m 7 17 solutions solution NOUN 8p58pc3099m 7 18 that that PRON 8p58pc3099m 7 19 mimic mimic VERB 8p58pc3099m 7 20 , , PUNCT 8p58pc3099m 7 21 as as ADV 8p58pc3099m 7 22 well well ADV 8p58pc3099m 7 23 as as ADP 8p58pc3099m 7 24 possible possible ADJ 8p58pc3099m 7 25 , , PUNCT 8p58pc3099m 7 26 the the DET 8p58pc3099m 7 27 biological biological ADJ 8p58pc3099m 7 28 environment environment NOUN 8p58pc3099m 7 29 . . PUNCT 8p58pc3099m 8 1 nmr nmr PROPN 8p58pc3099m 8 2 spectroscopy spectroscopy NOUN 8p58pc3099m 8 3 offers offer VERB 8p58pc3099m 8 4 a a DET 8p58pc3099m 8 5 powerful powerful ADJ 8p58pc3099m 8 6 means mean NOUN 8p58pc3099m 8 7 to to PART 8p58pc3099m 8 8 conduct conduct VERB 8p58pc3099m 8 9 these these DET 8p58pc3099m 8 10 studies study NOUN 8p58pc3099m 8 11 , , PUNCT 8p58pc3099m 8 12 partly partly ADV 8p58pc3099m 8 13 based base VERB 8p58pc3099m 8 14 on on ADP 8p58pc3099m 8 15 the the DET 8p58pc3099m 8 16 conformational conformational ADJ 8p58pc3099m 8 17 dependencies dependency NOUN 8p58pc3099m 8 18 of of ADP 8p58pc3099m 8 19 nmr nmr ADJ 8p58pc3099m 8 20 spin spin NOUN 8p58pc3099m 8 21 - - PUNCT 8p58pc3099m 8 22 spin spin NOUN 8p58pc3099m 8 23 coupling coupling NOUN 8p58pc3099m 8 24 constants constant NOUN 8p58pc3099m 8 25 involving involve VERB 8p58pc3099m 8 26 carbon carbon NOUN 8p58pc3099m 8 27 and and CCONJ 8p58pc3099m 8 28 hydrogen hydrogen NOUN 8p58pc3099m 8 29 ( ( PUNCT 8p58pc3099m 8 30 jh jh PROPN 8p58pc3099m 8 31 , , PUNCT 8p58pc3099m 8 32 h h PROPN 8p58pc3099m 8 33 , , PUNCT 8p58pc3099m 8 34 jc jc PROPN 8p58pc3099m 8 35 , , PUNCT 8p58pc3099m 8 36 h h PROPN 8p58pc3099m 8 37 , , PUNCT 8p58pc3099m 8 38 jc jc PROPN 8p58pc3099m 8 39 , , PUNCT 8p58pc3099m 8 40 c c PROPN 8p58pc3099m 8 41 ) ) PUNCT 8p58pc3099m 8 42 and and CCONJ 8p58pc3099m 8 43 other other ADJ 8p58pc3099m 8 44 nmr nmr NOUN 8p58pc3099m 8 45 parameters parameter NOUN 8p58pc3099m 8 46 . . PUNCT 8p58pc3099m 9 1 in in ADP 8p58pc3099m 9 2 this this DET 8p58pc3099m 9 3 dissertation dissertation NOUN 8p58pc3099m 9 4 , , PUNCT 8p58pc3099m 9 5 spin spin NOUN 8p58pc3099m 9 6 - - PUNCT 8p58pc3099m 9 7 spin spin NOUN 8p58pc3099m 9 8 coupling coupling NOUN 8p58pc3099m 9 9 constants constant NOUN 8p58pc3099m 9 10 measured measure VERB 8p58pc3099m 9 11 in in ADP 8p58pc3099m 9 12 these these DET 8p58pc3099m 9 13 compounds compound NOUN 8p58pc3099m 9 14 are be AUX 8p58pc3099m 9 15 interpreted interpret VERB 8p58pc3099m 9 16 using use VERB 8p58pc3099m 9 17 theoretically theoretically ADV 8p58pc3099m 9 18 - - PUNCT 8p58pc3099m 9 19 derived derive VERB 8p58pc3099m 9 20 karplus karplus ADJ 8p58pc3099m 9 21 or or CCONJ 8p58pc3099m 9 22 karplus karplus ADJ 8p58pc3099m 9 23 - - PUNCT 8p58pc3099m 9 24 like like ADJ 8p58pc3099m 9 25 relationships relationship NOUN 8p58pc3099m 9 26 between between ADP 8p58pc3099m 9 27 molecular molecular ADJ 8p58pc3099m 9 28 structure structure NOUN 8p58pc3099m 9 29 conformation conformation NOUN 8p58pc3099m 9 30 and and CCONJ 8p58pc3099m 9 31 coupling coupling NOUN 8p58pc3099m 9 32 magnitude magnitude NOUN 8p58pc3099m 9 33 . . PUNCT 8p58pc3099m 10 1 in in ADP 8p58pc3099m 10 2 chapter chapter NOUN 8p58pc3099m 10 3 2 2 NUM 8p58pc3099m 10 4 , , PUNCT 8p58pc3099m 10 5 fundamental fundamental ADJ 8p58pc3099m 10 6 studies study NOUN 8p58pc3099m 10 7 of of ADP 8p58pc3099m 10 8 j j NOUN 8p58pc3099m 10 9 - - PUNCT 8p58pc3099m 10 10 couplings coupling NOUN 8p58pc3099m 10 11 in in ADP 8p58pc3099m 10 12 biologically biologically ADV 8p58pc3099m 10 13 important important ADJ 8p58pc3099m 10 14 , , PUNCT 8p58pc3099m 10 15 isotopically isotopically ADV 8p58pc3099m 10 16 labeled label VERB 8p58pc3099m 10 17 hexuronic hexuronic ADJ 8p58pc3099m 10 18 acids acid NOUN 8p58pc3099m 10 19 ( ( PUNCT 8p58pc3099m 10 20 monosaccharide monosaccharide ADJ 8p58pc3099m 10 21 level level NOUN 8p58pc3099m 10 22 ) ) PUNCT 8p58pc3099m 10 23 are be AUX 8p58pc3099m 10 24 presented present VERB 8p58pc3099m 10 25 . . PUNCT 8p58pc3099m 11 1 chapter chapter NOUN 8p58pc3099m 11 2 3 3 NUM 8p58pc3099m 11 3 focuses focus VERB 8p58pc3099m 11 4 on on ADP 8p58pc3099m 11 5 conformational conformational ADJ 8p58pc3099m 11 6 and and CCONJ 8p58pc3099m 11 7 dynamics dynamic NOUN 8p58pc3099m 11 8 studies study NOUN 8p58pc3099m 11 9 of of ADP 8p58pc3099m 11 10 isotopically isotopically ADV 8p58pc3099m 11 11 - - PUNCT 8p58pc3099m 11 12 labeled label VERB 8p58pc3099m 11 13 mannose mannose NOUN 8p58pc3099m 11 14 - - PUNCT 8p58pc3099m 11 15 containing contain VERB 8p58pc3099m 11 16 oligosaccharides oligosaccharide NOUN 8p58pc3099m 11 17 that that PRON 8p58pc3099m 11 18 form form VERB 8p58pc3099m 11 19 part part NOUN 8p58pc3099m 11 20 of of ADP 8p58pc3099m 11 21 the the DET 8p58pc3099m 11 22 structures structure NOUN 8p58pc3099m 11 23 of of ADP 8p58pc3099m 11 24 high high ADJ 8p58pc3099m 11 25 - - PUNCT 8p58pc3099m 11 26 mannose mannose NOUN 8p58pc3099m 11 27 n n NOUN 8p58pc3099m 11 28 - - PUNCT 8p58pc3099m 11 29 glycans glycan NOUN 8p58pc3099m 11 30 of of ADP 8p58pc3099m 11 31 human human ADJ 8p58pc3099m 11 32 glycoproteins glycoprotein NOUN 8p58pc3099m 11 33 ( ( PUNCT 8p58pc3099m 11 34 oligosaccharide oligosaccharide NOUN 8p58pc3099m 11 35 level level NOUN 8p58pc3099m 11 36 ) ) PUNCT 8p58pc3099m 11 37 . . PUNCT 8p58pc3099m 12 1 concentrations concentration NOUN 8p58pc3099m 12 2 of of ADP 8p58pc3099m 12 3 3 3 NUM 8p58pc3099m 12 4 - - PUNCT 8p58pc3099m 12 5 deoxyglucosone deoxyglucosone NOUN 8p58pc3099m 12 6 ( ( PUNCT 8p58pc3099m 12 7 3dg 3dg NOUN 8p58pc3099m 12 8 ) ) PUNCT 8p58pc3099m 12 9 are be AUX 8p58pc3099m 12 10 elevated elevate VERB 8p58pc3099m 12 11 several several ADJ 8p58pc3099m 12 12 fold fold NOUN 8p58pc3099m 12 13 above above ADP 8p58pc3099m 12 14 normal normal ADJ 8p58pc3099m 12 15 levels level NOUN 8p58pc3099m 12 16 in in ADP 8p58pc3099m 12 17 serum serum NOUN 8p58pc3099m 12 18 and and CCONJ 8p58pc3099m 12 19 tissues tissue NOUN 8p58pc3099m 12 20 of of ADP 8p58pc3099m 12 21 diabetic diabetic ADJ 8p58pc3099m 12 22 patients patient NOUN 8p58pc3099m 12 23 . . PUNCT 8p58pc3099m 13 1 3dg 3dg NOUN 8p58pc3099m 13 2 can can AUX 8p58pc3099m 13 3 damage damage VERB 8p58pc3099m 13 4 protein protein NOUN 8p58pc3099m 13 5 functionality functionality NOUN 8p58pc3099m 13 6 and and CCONJ 8p58pc3099m 13 7 pyridoxamine pyridoxamine NOUN 8p58pc3099m 13 8 ( ( PUNCT 8p58pc3099m 13 9 pm pm NOUN 8p58pc3099m 13 10 ) ) PUNCT 8p58pc3099m 13 11 can can AUX 8p58pc3099m 13 12 protect protect VERB 8p58pc3099m 13 13 from from ADP 8p58pc3099m 13 14 3 3 NUM 8p58pc3099m 13 15 - - PUNCT 8p58pc3099m 13 16 dg dg NOUN 8p58pc3099m 13 17 - - PUNCT 8p58pc3099m 13 18 induced induce VERB 8p58pc3099m 13 19 protein protein NOUN 8p58pc3099m 13 20 damage damage NOUN 8p58pc3099m 13 21 . . PUNCT 8p58pc3099m 14 1 in in ADP 8p58pc3099m 14 2 chapter chapter NOUN 8p58pc3099m 14 3 4 4 NUM 8p58pc3099m 14 4 , , PUNCT 8p58pc3099m 14 5 a a DET 8p58pc3099m 14 6 novel novel ADJ 8p58pc3099m 14 7 protection protection NOUN 8p58pc3099m 14 8 mechanism mechanism NOUN 8p58pc3099m 14 9 involving involve VERB 8p58pc3099m 14 10 pm pm NOUN 8p58pc3099m 14 11 was be AUX 8p58pc3099m 14 12 investigated investigate VERB 8p58pc3099m 14 13 , , PUNCT 8p58pc3099m 14 14 which which PRON 8p58pc3099m 14 15 includes include VERB 8p58pc3099m 14 16 transient transient ADJ 8p58pc3099m 14 17 adduction adduction NOUN 8p58pc3099m 14 18 of of ADP 8p58pc3099m 14 19 3 3 NUM 8p58pc3099m 14 20 - - PUNCT 8p58pc3099m 14 21 dg dg NOUN 8p58pc3099m 14 22 by by ADP 8p58pc3099m 14 23 pm pm NOUN 8p58pc3099m 14 24 followed follow VERB 8p58pc3099m 14 25 by by ADP 8p58pc3099m 14 26 irreversible irreversible ADJ 8p58pc3099m 14 27 pm pm NOUN 8p58pc3099m 14 28 - - PUNCT 8p58pc3099m 14 29 mediated mediate VERB 8p58pc3099m 14 30 oxidative oxidative ADJ 8p58pc3099m 14 31 cleavage cleavage NOUN 8p58pc3099m 14 32 of of ADP 8p58pc3099m 14 33 3 3 NUM 8p58pc3099m 14 34 - - PUNCT 8p58pc3099m 14 35 dg dg NOUN 8p58pc3099m 14 36 . . PUNCT 8p58pc3099m 15 1 lastly lastly ADV 8p58pc3099m 15 2 , , PUNCT 8p58pc3099m 15 3 in in ADP 8p58pc3099m 15 4 chapter chapter NOUN 8p58pc3099m 15 5 5 5 NUM 8p58pc3099m 15 6 an an DET 8p58pc3099m 15 7 x x NUM 8p58pc3099m 15 8 - - NOUN 8p58pc3099m 15 9 ray ray NOUN 8p58pc3099m 15 10 crystal crystal NOUN 8p58pc3099m 15 11 structure structure NOUN 8p58pc3099m 15 12 of of ADP 8p58pc3099m 15 13 3 3 NUM 8p58pc3099m 15 14 - - PUNCT 8p58pc3099m 15 15 deoxy deoxy ADJ 8p58pc3099m 15 16 - - PUNCT 8p58pc3099m 15 17 beta beta NOUN 8p58pc3099m 15 18 - - PUNCT 8p58pc3099m 15 19 d d NOUN 8p58pc3099m 15 20 - - NOUN 8p58pc3099m 15 21 glucopyranose glucopyranose NOUN 8p58pc3099m 15 22 is be AUX 8p58pc3099m 15 23 presented present VERB 8p58pc3099m 15 24 with with ADP 8p58pc3099m 15 25 a a DET 8p58pc3099m 15 26 full full ADJ 8p58pc3099m 15 27 structural structural ADJ 8p58pc3099m 15 28 analysis analysis NOUN 8p58pc3099m 15 29 , , PUNCT 8p58pc3099m 15 30 including include VERB 8p58pc3099m 15 31 discussion discussion NOUN 8p58pc3099m 15 32 of of ADP 8p58pc3099m 15 33 ring ring NOUN 8p58pc3099m 15 34 - - PUNCT 8p58pc3099m 15 35 puckering pucker VERB 8p58pc3099m 15 36 behavior behavior NOUN 8p58pc3099m 15 37 and and CCONJ 8p58pc3099m 15 38 comparison comparison NOUN 8p58pc3099m 15 39 with with ADP 8p58pc3099m 15 40 other other ADJ 8p58pc3099m 15 41 structurally structurally ADV 8p58pc3099m 15 42 related relate VERB 8p58pc3099m 15 43 sugars sugar NOUN 8p58pc3099m 15 44 . . PUNCT