id sid tid token lemma pos b8515m62t70 1 1 rho rho PROPN b8515m62t70 1 2 gtpases gtpase NOUN b8515m62t70 1 3 and and CCONJ b8515m62t70 1 4 their their PRON b8515m62t70 1 5 regulators regulator NOUN b8515m62t70 1 6 , , PUNCT b8515m62t70 1 7 which which PRON b8515m62t70 1 8 are be AUX b8515m62t70 1 9 aberrantly aberrantly ADV b8515m62t70 1 10 expressed express VERB b8515m62t70 1 11 in in ADP b8515m62t70 1 12 breast breast NOUN b8515m62t70 1 13 cancer cancer NOUN b8515m62t70 1 14 , , PUNCT b8515m62t70 1 15 have have AUX b8515m62t70 1 16 been be AUX b8515m62t70 1 17 implicated implicate VERB b8515m62t70 1 18 as as ADP b8515m62t70 1 19 important important ADJ b8515m62t70 1 20 mediators mediator NOUN b8515m62t70 1 21 of of ADP b8515m62t70 1 22 extracellular extracellular ADJ b8515m62t70 1 23 signaling signaling NOUN b8515m62t70 1 24 between between ADP b8515m62t70 1 25 the the DET b8515m62t70 1 26 epithelial epithelial ADJ b8515m62t70 1 27 and and CCONJ b8515m62t70 1 28 stromal stromal ADJ b8515m62t70 1 29 compartments compartment NOUN b8515m62t70 1 30 . . PUNCT b8515m62t70 2 1 here here ADV b8515m62t70 2 2 we we PRON b8515m62t70 2 3 sought seek VERB b8515m62t70 2 4 to to PART b8515m62t70 2 5 elucidate elucidate VERB b8515m62t70 2 6 the the DET b8515m62t70 2 7 role role NOUN b8515m62t70 2 8 of of ADP b8515m62t70 2 9 rho rho NOUN b8515m62t70 2 10 gtpase gtpase NOUN b8515m62t70 2 11 signaling signal VERB b8515m62t70 2 12 in in ADP b8515m62t70 2 13 epithelial epithelial ADJ b8515m62t70 2 14 - - PUNCT b8515m62t70 2 15 stromal stromal NOUN b8515m62t70 2 16 interactions interaction NOUN b8515m62t70 2 17 in in ADP b8515m62t70 2 18 the the DET b8515m62t70 2 19 developing develop VERB b8515m62t70 2 20 mammary mammary ADJ b8515m62t70 2 21 gland gland NOUN b8515m62t70 2 22 using use VERB b8515m62t70 2 23 two two NUM b8515m62t70 2 24 mouse mouse NOUN b8515m62t70 2 25 models model NOUN b8515m62t70 2 26 of of ADP b8515m62t70 2 27 mammary mammary ADJ b8515m62t70 2 28 gland gland NOUN b8515m62t70 2 29 development development NOUN b8515m62t70 2 30 that that PRON b8515m62t70 2 31 conditionally conditionally ADV b8515m62t70 2 32 overexpress overexpress VERB b8515m62t70 2 33 different different ADJ b8515m62t70 2 34 components component NOUN b8515m62t70 2 35 of of ADP b8515m62t70 2 36 rho rho NOUN b8515m62t70 2 37 gtpase gtpase NOUN b8515m62t70 2 38 signaling signaling NOUN b8515m62t70 2 39 , , PUNCT b8515m62t70 2 40 a a DET b8515m62t70 2 41 rho rho NOUN b8515m62t70 2 42 gtpase gtpase NOUN b8515m62t70 2 43 regulator regulator NOUN b8515m62t70 2 44 p190b p190b ADV b8515m62t70 2 45 rho rho NOUN b8515m62t70 2 46 gap gap NOUN b8515m62t70 2 47 and and CCONJ b8515m62t70 2 48 the the DET b8515m62t70 2 49 rho rho PROPN b8515m62t70 2 50 gtpase gtpase NOUN b8515m62t70 2 51 cdc42 cdc42 PROPN b8515m62t70 2 52 , , PUNCT b8515m62t70 2 53 in in ADP b8515m62t70 2 54 the the DET b8515m62t70 2 55 mammary mammary ADJ b8515m62t70 2 56 epithelium epithelium NOUN b8515m62t70 2 57 . . PUNCT b8515m62t70 3 1 previous previous ADJ b8515m62t70 3 2 studies study NOUN b8515m62t70 3 3 with with ADP b8515m62t70 3 4 these these DET b8515m62t70 3 5 mouse mouse NOUN b8515m62t70 3 6 models model NOUN b8515m62t70 3 7 identified identify VERB b8515m62t70 3 8 stromal stromal ADJ b8515m62t70 3 9 alterations alteration NOUN b8515m62t70 3 10 reminiscent reminiscent ADJ b8515m62t70 3 11 of of ADP b8515m62t70 3 12 tumor tumor NOUN b8515m62t70 3 13 associated associate VERB b8515m62t70 3 14 stroma stroma PROPN b8515m62t70 3 15 in in ADP b8515m62t70 3 16 conjunction conjunction NOUN b8515m62t70 3 17 with with ADP b8515m62t70 3 18 increased increase VERB b8515m62t70 3 19 ductal ductal ADJ b8515m62t70 3 20 branching branching NOUN b8515m62t70 3 21 and and CCONJ b8515m62t70 3 22 aberrant aberrant ADJ b8515m62t70 3 23 terminal terminal ADJ b8515m62t70 3 24 end end NOUN b8515m62t70 3 25 bud bud PROPN b8515m62t70 3 26 ( ( PUNCT b8515m62t70 3 27 teb teb PROPN b8515m62t70 3 28 ) ) PUNCT b8515m62t70 3 29 formation formation NOUN b8515m62t70 3 30 in in ADP b8515m62t70 3 31 the the DET b8515m62t70 3 32 overexpressing overexpressing ADJ b8515m62t70 3 33 mammary mammary ADJ b8515m62t70 3 34 glands gland NOUN b8515m62t70 3 35 . . PUNCT b8515m62t70 4 1 interestingly interestingly ADV b8515m62t70 4 2 , , PUNCT b8515m62t70 4 3 our our PRON b8515m62t70 4 4 investigation investigation NOUN b8515m62t70 4 5 into into ADP b8515m62t70 4 6 the the DET b8515m62t70 4 7 mechanisms mechanism NOUN b8515m62t70 4 8 of of ADP b8515m62t70 4 9 stromal stromal ADJ b8515m62t70 4 10 activation activation NOUN b8515m62t70 4 11 in in ADP b8515m62t70 4 12 response response NOUN b8515m62t70 4 13 altered alter VERB b8515m62t70 4 14 rho rho PROPN b8515m62t70 4 15 signaling signal VERB b8515m62t70 4 16 in in ADP b8515m62t70 4 17 the the DET b8515m62t70 4 18 epithelium epithelium NOUN b8515m62t70 4 19 yielded yield VERB b8515m62t70 4 20 distinct distinct ADJ b8515m62t70 4 21 mechanisms mechanism NOUN b8515m62t70 4 22 for for ADP b8515m62t70 4 23 each each DET b8515m62t70 4 24 model model NOUN b8515m62t70 4 25 . . PUNCT b8515m62t70 5 1 stromal stromal ADJ b8515m62t70 5 2 activation activation NOUN b8515m62t70 5 3 characterized characterize VERB b8515m62t70 5 4 by by ADP b8515m62t70 5 5 increased increase VERB b8515m62t70 5 6 extracellular extracellular ADJ b8515m62t70 5 7 matrix matrix NOUN b8515m62t70 5 8 ( ( PUNCT b8515m62t70 5 9 ecm ecm NOUN b8515m62t70 5 10 ) ) PUNCT b8515m62t70 5 11 deposition deposition NOUN b8515m62t70 5 12 and and CCONJ b8515m62t70 5 13 remodeling remodeling NOUN b8515m62t70 5 14 in in ADP b8515m62t70 5 15 the the DET b8515m62t70 5 16 p190b p190b PROPN b8515m62t70 5 17 overexpressing overexpresse VERB b8515m62t70 5 18 mammary mammary ADJ b8515m62t70 5 19 glands gland NOUN b8515m62t70 5 20 appears appear VERB b8515m62t70 5 21 to to PART b8515m62t70 5 22 be be AUX b8515m62t70 5 23 due due ADJ b8515m62t70 5 24 in in ADP b8515m62t70 5 25 part part NOUN b8515m62t70 5 26 to to PART b8515m62t70 5 27 altered altered VERB b8515m62t70 5 28 mechanical mechanical ADJ b8515m62t70 5 29 signaling signaling NOUN b8515m62t70 5 30 between between ADP b8515m62t70 5 31 the the DET b8515m62t70 5 32 epithelial epithelial ADJ b8515m62t70 5 33 and and CCONJ b8515m62t70 5 34 stromal stromal ADJ b8515m62t70 5 35 compartments compartment NOUN b8515m62t70 5 36 and and CCONJ b8515m62t70 5 37 increased increase VERB b8515m62t70 5 38 paracrine paracrine NOUN b8515m62t70 5 39 tgfβ tgfβ PROPN b8515m62t70 5 40 ; ; PUNCT b8515m62t70 5 41 singaling singale VERB b8515m62t70 5 42 from from ADP b8515m62t70 5 43 the the DET b8515m62t70 5 44 p190b p190b PROPN b8515m62t70 5 45 overexpressing overexpresse VERB b8515m62t70 5 46 mammary mammary ADJ b8515m62t70 5 47 epithelial epithelial ADJ b8515m62t70 5 48 cells cell NOUN b8515m62t70 5 49 ( ( PUNCT b8515m62t70 5 50 mecs mecs PROPN b8515m62t70 5 51 ) ) PUNCT b8515m62t70 5 52 . . PUNCT b8515m62t70 6 1 while while SCONJ b8515m62t70 6 2 the the DET b8515m62t70 6 3 cdc42 cdc42 NOUN b8515m62t70 6 4 overexpressing overexpresse VERB b8515m62t70 6 5 mammary mammary ADJ b8515m62t70 6 6 glands gland NOUN b8515m62t70 6 7 also also ADV b8515m62t70 6 8 demonstrated demonstrate VERB b8515m62t70 6 9 increased increase VERB b8515m62t70 6 10 levels level NOUN b8515m62t70 6 11 of of ADP b8515m62t70 6 12 ecm ecm NOUN b8515m62t70 6 13 proteins protein NOUN b8515m62t70 6 14 and and CCONJ b8515m62t70 6 15 remodeling remodeling NOUN b8515m62t70 6 16 enzymes enzyme NOUN b8515m62t70 6 17 , , PUNCT b8515m62t70 6 18 the the DET b8515m62t70 6 19 stroma stroma NOUN b8515m62t70 6 20 was be AUX b8515m62t70 6 21 additionally additionally ADV b8515m62t70 6 22 characterized characterize VERB b8515m62t70 6 23 by by ADP b8515m62t70 6 24 differential differential ADJ b8515m62t70 6 25 activation activation NOUN b8515m62t70 6 26 of of ADP b8515m62t70 6 27 the the DET b8515m62t70 6 28 macrophage macrophage NOUN b8515m62t70 6 29 population population NOUN b8515m62t70 6 30 . . PUNCT b8515m62t70 7 1 interestingly interestingly ADV b8515m62t70 7 2 , , PUNCT b8515m62t70 7 3 cdc42 cdc42 NOUN b8515m62t70 7 4 overexpressing overexpresse VERB b8515m62t70 7 5 mammary mammary ADJ b8515m62t70 7 6 glands gland NOUN b8515m62t70 7 7 were be AUX b8515m62t70 7 8 found find VERB b8515m62t70 7 9 to to PART b8515m62t70 7 10 contain contain VERB b8515m62t70 7 11 more more ADJ b8515m62t70 7 12 senescent senescent ADJ b8515m62t70 7 13 mecs mecs NOUN b8515m62t70 7 14 and and CCONJ b8515m62t70 7 15 an an DET b8515m62t70 7 16 altered altered ADJ b8515m62t70 7 17 secretory secretory NOUN b8515m62t70 7 18 profile profile NOUN b8515m62t70 7 19 that that PRON b8515m62t70 7 20 appears appear VERB b8515m62t70 7 21 to to PART b8515m62t70 7 22 be be AUX b8515m62t70 7 23 contributing contribute VERB b8515m62t70 7 24 to to ADP b8515m62t70 7 25 the the DET b8515m62t70 7 26 pro pro ADJ b8515m62t70 7 27 - - ADJ b8515m62t70 7 28 inflammatory inflammatory ADJ b8515m62t70 7 29 activation activation NOUN b8515m62t70 7 30 of of ADP b8515m62t70 7 31 the the DET b8515m62t70 7 32 adjacent adjacent ADJ b8515m62t70 7 33 stroma stroma PROPN b8515m62t70 7 34 . . PUNCT b8515m62t70 8 1 collectively collectively ADV b8515m62t70 8 2 , , PUNCT b8515m62t70 8 3 our our PRON b8515m62t70 8 4 studies study NOUN b8515m62t70 8 5 demonstrate demonstrate VERB b8515m62t70 8 6 that that SCONJ b8515m62t70 8 7 altered alter VERB b8515m62t70 8 8 rho rho NOUN b8515m62t70 8 9 gtpase gtpase NOUN b8515m62t70 8 10 signaling signal VERB b8515m62t70 8 11 in in ADP b8515m62t70 8 12 the the DET b8515m62t70 8 13 epithelium epithelium NOUN b8515m62t70 8 14 dramatically dramatically ADV b8515m62t70 8 15 alters alter VERB b8515m62t70 8 16 the the DET b8515m62t70 8 17 adjacent adjacent ADJ b8515m62t70 8 18 environment environment NOUN b8515m62t70 8 19 through through ADP b8515m62t70 8 20 multiple multiple ADJ b8515m62t70 8 21 mechanisms mechanism NOUN b8515m62t70 8 22 involving involve VERB b8515m62t70 8 23 aberrant aberrant ADJ b8515m62t70 8 24 epithelial epithelial ADJ b8515m62t70 8 25 - - PUNCT b8515m62t70 8 26 stromal stromal NOUN b8515m62t70 8 27 interactions interaction NOUN b8515m62t70 8 28 . . PUNCT b8515m62t70 9 1 furthermore furthermore ADV b8515m62t70 9 2 , , PUNCT b8515m62t70 9 3 our our PRON b8515m62t70 9 4 work work NOUN b8515m62t70 9 5 highlights highlight VERB b8515m62t70 9 6 the the DET b8515m62t70 9 7 need need NOUN b8515m62t70 9 8 for for ADP b8515m62t70 9 9 future future ADJ b8515m62t70 9 10 studies study NOUN b8515m62t70 9 11 investigating investigate VERB b8515m62t70 9 12 the the DET b8515m62t70 9 13 involvement involvement NOUN b8515m62t70 9 14 of of ADP b8515m62t70 9 15 aberrant aberrant ADJ b8515m62t70 9 16 rho rho NOUN b8515m62t70 9 17 gtpase gtpase NOUN b8515m62t70 9 18 signaling signal VERB b8515m62t70 9 19 in in ADP b8515m62t70 9 20 creating create VERB b8515m62t70 9 21 a a DET b8515m62t70 9 22 microenvironment microenvironment NOUN b8515m62t70 9 23 permissive permissive NOUN b8515m62t70 9 24 to to ADP b8515m62t70 9 25 breast breast NOUN b8515m62t70 9 26 cancer cancer NOUN b8515m62t70 9 27 development development NOUN b8515m62t70 9 28 and and CCONJ b8515m62t70 9 29 progression progression NOUN b8515m62t70 9 30 . . PUNCT