id sid tid token lemma pos c821gh95k6p 1 1 this this DET c821gh95k6p 1 2 thesis thesis NOUN c821gh95k6p 1 3 details detail VERB c821gh95k6p 1 4 the the DET c821gh95k6p 1 5 synthetic synthetic ADJ c821gh95k6p 1 6 progress progress NOUN c821gh95k6p 1 7 towards towards ADP c821gh95k6p 1 8 the the DET c821gh95k6p 1 9 preparation preparation NOUN c821gh95k6p 1 10 of of ADP c821gh95k6p 1 11 myriaporone myriaporone NOUN c821gh95k6p 1 12 - - PUNCT c821gh95k6p 1 13 tedanolide tedanolide NOUN c821gh95k6p 1 14 analogues analogue NOUN c821gh95k6p 1 15 through through ADP c821gh95k6p 1 16 novel novel ADJ c821gh95k6p 1 17 precursor precursor NOUN c821gh95k6p 1 18 - - PUNCT c821gh95k6p 1 19 directed direct VERB c821gh95k6p 1 20 biosynthesis biosynthesis NOUN c821gh95k6p 1 21 as as ADV c821gh95k6p 1 22 well well ADV c821gh95k6p 1 23 as as ADP c821gh95k6p 1 24 general general ADJ c821gh95k6p 1 25 organic organic ADJ c821gh95k6p 1 26 synthesis synthesis NOUN c821gh95k6p 1 27 . . PUNCT c821gh95k6p 2 1 with with ADP c821gh95k6p 2 2 the the DET c821gh95k6p 2 3 recent recent ADJ c821gh95k6p 2 4 completion completion NOUN c821gh95k6p 2 5 of of ADP c821gh95k6p 2 6 the the DET c821gh95k6p 2 7 total total ADJ c821gh95k6p 2 8 synthesis synthesis NOUN c821gh95k6p 2 9 of of ADP c821gh95k6p 2 10 the the DET c821gh95k6p 2 11 cytotoxic cytotoxic ADJ c821gh95k6p 2 12 natural natural ADJ c821gh95k6p 2 13 products product NOUN c821gh95k6p 2 14 myriaporones myriaporone NOUN c821gh95k6p 2 15 1 1 NUM c821gh95k6p 2 16 , , PUNCT c821gh95k6p 2 17 3 3 NUM c821gh95k6p 2 18 and and CCONJ c821gh95k6p 2 19 4 4 NUM c821gh95k6p 2 20 in in ADP c821gh95k6p 2 21 our our PRON c821gh95k6p 2 22 group group NOUN c821gh95k6p 2 23 , , PUNCT c821gh95k6p 2 24 our our PRON c821gh95k6p 2 25 focus focus NOUN c821gh95k6p 2 26 has have AUX c821gh95k6p 2 27 switched switch VERB c821gh95k6p 2 28 to to PART c821gh95k6p 2 29 prepare prepare VERB c821gh95k6p 2 30 analogues analogue NOUN c821gh95k6p 2 31 of of ADP c821gh95k6p 2 32 myriaporones myriaporone NOUN c821gh95k6p 2 33 , , PUNCT c821gh95k6p 2 34 including include VERB c821gh95k6p 2 35 more more ADJ c821gh95k6p 2 36 structurally structurally ADV c821gh95k6p 2 37 complex complex ADJ c821gh95k6p 2 38 myriaporone myriaporone NOUN c821gh95k6p 2 39 - - PUNCT c821gh95k6p 2 40 tedanolide tedanolide NOUN c821gh95k6p 2 41 hybrids hybrid NOUN c821gh95k6p 2 42 . . PUNCT c821gh95k6p 3 1 by by ADP c821gh95k6p 3 2 generating generate VERB c821gh95k6p 3 3 these these DET c821gh95k6p 3 4 analogues analogue NOUN c821gh95k6p 3 5 that that PRON c821gh95k6p 3 6 are be AUX c821gh95k6p 3 7 biased bias VERB c821gh95k6p 3 8 toward toward ADP c821gh95k6p 3 9 specific specific ADJ c821gh95k6p 3 10 conformations conformation NOUN c821gh95k6p 3 11 , , PUNCT c821gh95k6p 3 12 we we PRON c821gh95k6p 3 13 hope hope VERB c821gh95k6p 3 14 to to PART c821gh95k6p 3 15 maximize maximize VERB c821gh95k6p 3 16 biological biological ADJ c821gh95k6p 3 17 activity activity NOUN c821gh95k6p 3 18 and and CCONJ c821gh95k6p 3 19 learn learn VERB c821gh95k6p 3 20 more more ADJ c821gh95k6p 3 21 about about ADP c821gh95k6p 3 22 the the DET c821gh95k6p 3 23 relationship relationship NOUN c821gh95k6p 3 24 between between ADP c821gh95k6p 3 25 the the DET c821gh95k6p 3 26 myriaporones myriaporone NOUN c821gh95k6p 3 27 and and CCONJ c821gh95k6p 3 28 tedanolides tedanolide NOUN c821gh95k6p 3 29 . . PUNCT c821gh95k6p 4 1 here here ADV c821gh95k6p 4 2 , , PUNCT c821gh95k6p 4 3 we we PRON c821gh95k6p 4 4 are be AUX c821gh95k6p 4 5 exploring explore VERB c821gh95k6p 4 6 an an DET c821gh95k6p 4 7 alternative alternative ADJ c821gh95k6p 4 8 synthesis synthesis NOUN c821gh95k6p 4 9 of of ADP c821gh95k6p 4 10 these these DET c821gh95k6p 4 11 compounds compound NOUN c821gh95k6p 4 12 through through ADP c821gh95k6p 4 13 the the DET c821gh95k6p 4 14 use use NOUN c821gh95k6p 4 15 of of ADP c821gh95k6p 4 16 modular modular ADJ c821gh95k6p 4 17 polyketide polyketide NOUN c821gh95k6p 4 18 synthase.an synthase.an X c821gh95k6p 4 19 efficient efficient ADJ c821gh95k6p 4 20 synthetic synthetic ADJ c821gh95k6p 4 21 sequence sequence NOUN c821gh95k6p 4 22 toward toward ADP c821gh95k6p 4 23 the the DET c821gh95k6p 4 24 diketide diketide NOUN c821gh95k6p 4 25 biosynthesis biosynthesis NOUN c821gh95k6p 4 26 precursor precursor NOUN c821gh95k6p 4 27 in in ADP c821gh95k6p 4 28 7 7 NUM c821gh95k6p 4 29 linear linear ADJ c821gh95k6p 4 30 steps step NOUN c821gh95k6p 4 31 is be AUX c821gh95k6p 4 32 discussed discuss VERB c821gh95k6p 4 33 in in ADP c821gh95k6p 4 34 this this DET c821gh95k6p 4 35 thesis thesis NOUN c821gh95k6p 4 36 . . PUNCT c821gh95k6p 5 1 the the DET c821gh95k6p 5 2 enzymes enzyme NOUN c821gh95k6p 5 3 , , PUNCT c821gh95k6p 5 4 module module NOUN c821gh95k6p 5 5 2 2 NUM c821gh95k6p 5 6 and and CCONJ c821gh95k6p 5 7 module module NOUN c821gh95k6p 5 8 3 3 NUM c821gh95k6p 5 9 plus plus CCONJ c821gh95k6p 5 10 thioesterase thioesterase NOUN c821gh95k6p 5 11 of of ADP c821gh95k6p 5 12 6 6 NUM c821gh95k6p 5 13 - - PUNCT c821gh95k6p 5 14 deoxyerythronolide deoxyerythronolide NOUN c821gh95k6p 5 15 b b NOUN c821gh95k6p 5 16 synthase synthase NOUN c821gh95k6p 5 17 , , PUNCT c821gh95k6p 5 18 are be AUX c821gh95k6p 5 19 successfully successfully ADV c821gh95k6p 5 20 expressed express VERB c821gh95k6p 5 21 in in ADP c821gh95k6p 5 22 escherichia escherichia PROPN c821gh95k6p 5 23 coli coli PROPN c821gh95k6p 5 24 bap1 bap1 PROPN c821gh95k6p 5 25 and and CCONJ c821gh95k6p 5 26 purified purify VERB c821gh95k6p 5 27 . . PUNCT c821gh95k6p 6 1 another another DET c821gh95k6p 6 2 synthetic synthetic ADJ c821gh95k6p 6 3 sequence sequence NOUN c821gh95k6p 6 4 towards towards ADP c821gh95k6p 6 5 the the DET c821gh95k6p 6 6 preparation preparation NOUN c821gh95k6p 6 7 of of ADP c821gh95k6p 6 8 the the DET c821gh95k6p 6 9 biosynthesis biosynthesis NOUN c821gh95k6p 6 10 product product NOUN c821gh95k6p 6 11 was be AUX c821gh95k6p 6 12 close close ADJ c821gh95k6p 6 13 to to PART c821gh95k6p 6 14 be be AUX c821gh95k6p 6 15 finished finish VERB c821gh95k6p 6 16 to to PART c821gh95k6p 6 17 help help AUX c821gh95k6p 6 18 identify identify VERB c821gh95k6p 6 19 it it PRON c821gh95k6p 6 20 . . PUNCT