id sid tid token lemma pos cv43nv9584s 1 1 coronary coronary ADJ cv43nv9584s 1 2 heart heart NOUN cv43nv9584s 1 3 disease disease NOUN cv43nv9584s 1 4 is be AUX cv43nv9584s 1 5 the the DET cv43nv9584s 1 6 leading lead VERB cv43nv9584s 1 7 cause cause NOUN cv43nv9584s 1 8 of of ADP cv43nv9584s 1 9 mortality mortality NOUN cv43nv9584s 1 10 in in ADP cv43nv9584s 1 11 the the DET cv43nv9584s 1 12 u.s u.s PROPN cv43nv9584s 1 13 . . PROPN cv43nv9584s 1 14 and and CCONJ cv43nv9584s 1 15 other other ADJ cv43nv9584s 1 16 western western ADJ cv43nv9584s 1 17 countries country NOUN cv43nv9584s 1 18 . . PUNCT cv43nv9584s 2 1 two two NUM cv43nv9584s 2 2 risk risk NOUN cv43nv9584s 2 3 factors factor NOUN cv43nv9584s 2 4 for for ADP cv43nv9584s 2 5 development development NOUN cv43nv9584s 2 6 of of ADP cv43nv9584s 2 7 this this DET cv43nv9584s 2 8 disease disease NOUN cv43nv9584s 2 9 are be AUX cv43nv9584s 2 10 elevated elevate VERB cv43nv9584s 2 11 total total ADJ cv43nv9584s 2 12 cholesterol cholesterol NOUN cv43nv9584s 2 13 ( ( PUNCT cv43nv9584s 2 14 tc tc NOUN cv43nv9584s 2 15 ) ) PUNCT cv43nv9584s 2 16 and and CCONJ cv43nv9584s 2 17 low low ADJ cv43nv9584s 2 18 - - PUNCT cv43nv9584s 2 19 density density NOUN cv43nv9584s 2 20 lipoprotein lipoprotein NOUN cv43nv9584s 2 21 cholesterol cholesterol NOUN cv43nv9584s 2 22 ( ( PUNCT cv43nv9584s 2 23 ldl ldl NOUN cv43nv9584s 2 24 - - PUNCT cv43nv9584s 2 25 c c NOUN cv43nv9584s 2 26 ) ) PUNCT cv43nv9584s 2 27 levels level NOUN cv43nv9584s 2 28 . . PUNCT cv43nv9584s 3 1 therapies therapy NOUN cv43nv9584s 3 2 for for ADP cv43nv9584s 3 3 highly highly ADV cv43nv9584s 3 4 elevated elevated ADJ cv43nv9584s 3 5 cholesterol cholesterol NOUN cv43nv9584s 3 6 levels level NOUN cv43nv9584s 3 7 generally generally ADV cv43nv9584s 3 8 include include VERB cv43nv9584s 3 9 dietary dietary ADJ cv43nv9584s 3 10 modification modification NOUN cv43nv9584s 3 11 and and CCONJ cv43nv9584s 3 12 pharmaceutical pharmaceutical ADJ cv43nv9584s 3 13 treatment treatment NOUN cv43nv9584s 3 14 . . PUNCT cv43nv9584s 4 1 soy soy NOUN cv43nv9584s 4 2 consumption consumption NOUN cv43nv9584s 4 3 lowers lower VERB cv43nv9584s 4 4 tc tc PROPN cv43nv9584s 4 5 and and CCONJ cv43nv9584s 4 6 ldl ldl PROPN cv43nv9584s 4 7 - - PUNCT cv43nv9584s 4 8 c c NOUN cv43nv9584s 4 9 ; ; PUNCT cv43nv9584s 4 10 replacing replace VERB cv43nv9584s 4 11 animal animal NOUN cv43nv9584s 4 12 protein protein NOUN cv43nv9584s 4 13 sources source NOUN cv43nv9584s 4 14 with with ADP cv43nv9584s 4 15 soy soy NOUN cv43nv9584s 4 16 protein protein NOUN cv43nv9584s 4 17 in in ADP cv43nv9584s 4 18 the the DET cv43nv9584s 4 19 diet diet NOUN cv43nv9584s 4 20 is be AUX cv43nv9584s 4 21 a a DET cv43nv9584s 4 22 suggested suggest VERB cv43nv9584s 4 23 dietary dietary ADJ cv43nv9584s 4 24 modification modification NOUN cv43nv9584s 4 25 to to PART cv43nv9584s 4 26 improve improve VERB cv43nv9584s 4 27 cholesterol cholesterol NOUN cv43nv9584s 4 28 profiles profile NOUN cv43nv9584s 4 29 . . PUNCT cv43nv9584s 5 1 however however ADV cv43nv9584s 5 2 , , PUNCT cv43nv9584s 5 3 the the DET cv43nv9584s 5 4 mechanism mechanism NOUN cv43nv9584s 5 5 by by ADP cv43nv9584s 5 6 which which PRON cv43nv9584s 5 7 soy soy NOUN cv43nv9584s 5 8 improves improve VERB cv43nv9584s 5 9 cholesterol cholesterol NOUN cv43nv9584s 5 10 profiles profile NOUN cv43nv9584s 5 11 is be AUX cv43nv9584s 5 12 unknown unknown ADJ cv43nv9584s 5 13 . . PUNCT cv43nv9584s 6 1 we we PRON cv43nv9584s 6 2 hypothesize hypothesize VERB cv43nv9584s 6 3 that that SCONJ cv43nv9584s 6 4 consumption consumption NOUN cv43nv9584s 6 5 of of ADP cv43nv9584s 6 6 soy soy NOUN cv43nv9584s 6 7 isoflavones isoflavone NOUN cv43nv9584s 6 8 can can AUX cv43nv9584s 6 9 alter alter VERB cv43nv9584s 6 10 gene gene NOUN cv43nv9584s 6 11 expression expression NOUN cv43nv9584s 6 12 in in ADP cv43nv9584s 6 13 human human ADJ cv43nv9584s 6 14 and and CCONJ cv43nv9584s 6 15 rodent rodent NOUN cv43nv9584s 6 16 models model NOUN cv43nv9584s 6 17 , , PUNCT cv43nv9584s 6 18 and and CCONJ cv43nv9584s 6 19 that that SCONJ cv43nv9584s 6 20 this this PRON cv43nv9584s 6 21 may may AUX cv43nv9584s 6 22 be be AUX cv43nv9584s 6 23 one one NUM cv43nv9584s 6 24 mechanism mechanism NOUN cv43nv9584s 6 25 by by ADP cv43nv9584s 6 26 which which PRON cv43nv9584s 6 27 soy soy NOUN cv43nv9584s 6 28 lowers lower VERB cv43nv9584s 6 29 cholesterol.in cholesterol.in ADP cv43nv9584s 6 30 addition addition NOUN cv43nv9584s 6 31 to to ADP cv43nv9584s 6 32 dietary dietary ADJ cv43nv9584s 6 33 modification modification NOUN cv43nv9584s 6 34 , , PUNCT cv43nv9584s 6 35 some some DET cv43nv9584s 6 36 individuals individual NOUN cv43nv9584s 6 37 augment augment VERB cv43nv9584s 6 38 their their PRON cv43nv9584s 6 39 diet diet NOUN cv43nv9584s 6 40 with with ADP cv43nv9584s 6 41 soy soy NOUN cv43nv9584s 6 42 extract extract NOUN cv43nv9584s 6 43 supplements supplement NOUN cv43nv9584s 6 44 . . PUNCT cv43nv9584s 7 1 some some DET cv43nv9584s 7 2 dietary dietary ADJ cv43nv9584s 7 3 supplements supplement NOUN cv43nv9584s 7 4 have have AUX cv43nv9584s 7 5 been be AUX cv43nv9584s 7 6 demonstrated demonstrate VERB cv43nv9584s 7 7 to to PART cv43nv9584s 7 8 alter alter VERB cv43nv9584s 7 9 the the DET cv43nv9584s 7 10 effectiveness effectiveness NOUN cv43nv9584s 7 11 of of ADP cv43nv9584s 7 12 conventional conventional ADJ cv43nv9584s 7 13 drugs drug NOUN cv43nv9584s 7 14 . . PUNCT cv43nv9584s 8 1 since since SCONJ cv43nv9584s 8 2 lipidand lipidand PROPN cv43nv9584s 8 3 cholesterol cholesterol NOUN cv43nv9584s 8 4 - - PUNCT cv43nv9584s 8 5 lowering lower VERB cv43nv9584s 8 6 drugs drug NOUN cv43nv9584s 8 7 are be AUX cv43nv9584s 8 8 often often ADV cv43nv9584s 8 9 prescribed prescribe VERB cv43nv9584s 8 10 concurrently concurrently ADV cv43nv9584s 8 11 with with ADP cv43nv9584s 8 12 dietary dietary ADJ cv43nv9584s 8 13 modification modification NOUN cv43nv9584s 8 14 , , PUNCT cv43nv9584s 8 15 we we PRON cv43nv9584s 8 16 are be AUX cv43nv9584s 8 17 interested interested ADJ cv43nv9584s 8 18 in in ADP cv43nv9584s 8 19 elucidating elucidate VERB cv43nv9584s 8 20 potential potential ADJ cv43nv9584s 8 21 interactions interaction NOUN cv43nv9584s 8 22 of of ADP cv43nv9584s 8 23 soy soy NOUN cv43nv9584s 8 24 isoflavones isoflavone NOUN cv43nv9584s 8 25 with with ADP cv43nv9584s 8 26 prescription prescription NOUN cv43nv9584s 8 27 drugs drug NOUN cv43nv9584s 8 28 . . PUNCT cv43nv9584s 9 1 we we PRON cv43nv9584s 9 2 have have AUX cv43nv9584s 9 3 shown show VERB cv43nv9584s 9 4 that that SCONJ cv43nv9584s 9 5 mice mouse NOUN cv43nv9584s 9 6 consuming consume VERB cv43nv9584s 9 7 a a DET cv43nv9584s 9 8 diet diet NOUN cv43nv9584s 9 9 containing contain VERB cv43nv9584s 9 10 both both DET cv43nv9584s 9 11 a a DET cv43nv9584s 9 12 triglyceride triglyceride NOUN cv43nv9584s 9 13 - - PUNCT cv43nv9584s 9 14 lowering lower VERB cv43nv9584s 9 15 drug drug NOUN cv43nv9584s 9 16 ( ( PUNCT cv43nv9584s 9 17 fenofibrate fenofibrate VERB cv43nv9584s 9 18 ) ) PUNCT cv43nv9584s 9 19 and and CCONJ cv43nv9584s 9 20 soy soy NOUN cv43nv9584s 9 21 isoflavones isoflavone NOUN cv43nv9584s 9 22 had have VERB cv43nv9584s 9 23 lower low ADJ cv43nv9584s 9 24 serum serum NOUN cv43nv9584s 9 25 and and CCONJ cv43nv9584s 9 26 urinary urinary ADJ cv43nv9584s 9 27 and and CCONJ cv43nv9584s 9 28 higher high ADJ cv43nv9584s 9 29 fecal fecal ADJ cv43nv9584s 9 30 fenofibrate fenofibrate NOUN cv43nv9584s 9 31 concentrations concentration NOUN cv43nv9584s 9 32 than than ADP cv43nv9584s 9 33 mice mouse NOUN cv43nv9584s 9 34 consuming consume VERB cv43nv9584s 9 35 a a DET cv43nv9584s 9 36 diet diet NOUN cv43nv9584s 9 37 without without ADP cv43nv9584s 9 38 isoflavones isoflavone NOUN cv43nv9584s 9 39 . . PUNCT cv43nv9584s 10 1 additionally additionally ADV cv43nv9584s 10 2 , , PUNCT cv43nv9584s 10 3 genes gene NOUN cv43nv9584s 10 4 critical critical ADJ cv43nv9584s 10 5 to to ADP cv43nv9584s 10 6 the the DET cv43nv9584s 10 7 bile bile NOUN cv43nv9584s 10 8 synthesis synthesis NOUN cv43nv9584s 10 9 pathway pathway NOUN cv43nv9584s 10 10 were be AUX cv43nv9584s 10 11 identified identify VERB cv43nv9584s 10 12 in in ADP cv43nv9584s 10 13 this this DET cv43nv9584s 10 14 work work NOUN cv43nv9584s 10 15 to to PART cv43nv9584s 10 16 be be AUX cv43nv9584s 10 17 induced induce VERB cv43nv9584s 10 18 in in ADP cv43nv9584s 10 19 mice mouse NOUN cv43nv9584s 10 20 consuming consume VERB cv43nv9584s 10 21 an an DET cv43nv9584s 10 22 isoflavone isoflavone NOUN cv43nv9584s 10 23 - - PUNCT cv43nv9584s 10 24 containing contain VERB cv43nv9584s 10 25 diet diet NOUN cv43nv9584s 10 26 . . PUNCT cv43nv9584s 11 1 mice mouse NOUN cv43nv9584s 11 2 consuming consume VERB cv43nv9584s 11 3 a a DET cv43nv9584s 11 4 diet diet NOUN cv43nv9584s 11 5 high high ADJ cv43nv9584s 11 6 in in ADP cv43nv9584s 11 7 isoflavones isoflavone NOUN cv43nv9584s 11 8 demonstrated demonstrate VERB cv43nv9584s 11 9 increased increase VERB cv43nv9584s 11 10 mrna mrna PROPN cv43nv9584s 11 11 levels level NOUN cv43nv9584s 11 12 of of ADP cv43nv9584s 11 13 cyp7a1 cyp7a1 PROPN cv43nv9584s 11 14 and and CCONJ cv43nv9584s 11 15 cyp27a1 cyp27a1 PROPN cv43nv9584s 11 16 ( ( PUNCT cv43nv9584s 11 17 the the DET cv43nv9584s 11 18 rate rate NOUN cv43nv9584s 11 19 - - PUNCT cv43nv9584s 11 20 limiting limit VERB cv43nv9584s 11 21 steps step NOUN cv43nv9584s 11 22 of of ADP cv43nv9584s 11 23 the the DET cv43nv9584s 11 24 classic classic ADJ cv43nv9584s 11 25 and and CCONJ cv43nv9584s 11 26 alternative alternative ADJ cv43nv9584s 11 27 bile bile NOUN cv43nv9584s 11 28 acid acid NOUN cv43nv9584s 11 29 synthetic synthetic ADJ cv43nv9584s 11 30 pathways pathway NOUN cv43nv9584s 11 31 , , PUNCT cv43nv9584s 11 32 respectively respectively ADV cv43nv9584s 11 33 ) ) PUNCT cv43nv9584s 11 34 , , PUNCT cv43nv9584s 11 35 as as ADV cv43nv9584s 11 36 well well ADV cv43nv9584s 11 37 as as ADP cv43nv9584s 11 38 decreased decrease VERB cv43nv9584s 11 39 mrna mrna PROPN cv43nv9584s 11 40 levels level NOUN cv43nv9584s 11 41 of of ADP cv43nv9584s 11 42 asbt asbt PROPN cv43nv9584s 11 43 ( ( PUNCT cv43nv9584s 11 44 a a DET cv43nv9584s 11 45 transporter transporter NOUN cv43nv9584s 11 46 which which PRON cv43nv9584s 11 47 recovers recover VERB cv43nv9584s 11 48 bile bile NOUN cv43nv9584s 11 49 acids acid NOUN cv43nv9584s 11 50 back back ADV cv43nv9584s 11 51 into into ADP cv43nv9584s 11 52 enterohepatic enterohepatic ADJ cv43nv9584s 11 53 recirculation recirculation NOUN cv43nv9584s 11 54 ) ) PUNCT cv43nv9584s 11 55 . . PUNCT cv43nv9584s 12 1 the the DET cv43nv9584s 12 2 outcome outcome NOUN cv43nv9584s 12 3 of of ADP cv43nv9584s 12 4 these these DET cv43nv9584s 12 5 changes change NOUN cv43nv9584s 12 6 would would AUX cv43nv9584s 12 7 be be AUX cv43nv9584s 12 8 a a DET cv43nv9584s 12 9 decrease decrease NOUN cv43nv9584s 12 10 in in ADP cv43nv9584s 12 11 recovered recover VERB cv43nv9584s 12 12 bile bile NOUN cv43nv9584s 12 13 acids acid NOUN cv43nv9584s 12 14 and and CCONJ cv43nv9584s 12 15 a a DET cv43nv9584s 12 16 resulting result VERB cv43nv9584s 12 17 increase increase NOUN cv43nv9584s 12 18 in in ADP cv43nv9584s 12 19 conversion conversion NOUN cv43nv9584s 12 20 of of ADP cv43nv9584s 12 21 cholesterol cholesterol NOUN cv43nv9584s 12 22 to to PART cv43nv9584s 12 23 keep keep VERB cv43nv9584s 12 24 the the DET cv43nv9584s 12 25 bile bile NOUN cv43nv9584s 12 26 acid acid NOUN cv43nv9584s 12 27 pool pool NOUN cv43nv9584s 12 28 in in ADP cv43nv9584s 12 29 homeostasis homeostasis NOUN cv43nv9584s 12 30 . . PUNCT cv43nv9584s 13 1 serum serum NOUN cv43nv9584s 13 2 total total ADJ cv43nv9584s 13 3 bile bile NOUN cv43nv9584s 13 4 acids acid NOUN cv43nv9584s 13 5 decreased decrease VERB cv43nv9584s 13 6 in in ADP cv43nv9584s 13 7 keeping keep VERB cv43nv9584s 13 8 with with ADP cv43nv9584s 13 9 the the DET cv43nv9584s 13 10 mrna mrna PROPN cv43nv9584s 13 11 changes change NOUN cv43nv9584s 13 12 . . PUNCT cv43nv9584s 14 1 we we PRON cv43nv9584s 14 2 also also ADV cv43nv9584s 14 3 found find VERB cv43nv9584s 14 4 that that SCONJ cv43nv9584s 14 5 the the DET cv43nv9584s 14 6 effects effect NOUN cv43nv9584s 14 7 were be AUX cv43nv9584s 14 8 greatest great ADJ cv43nv9584s 14 9 when when SCONJ cv43nv9584s 14 10 cholesterol cholesterol NOUN cv43nv9584s 14 11 was be AUX cv43nv9584s 14 12 provided provide VERB cv43nv9584s 14 13 in in ADP cv43nv9584s 14 14 the the DET cv43nv9584s 14 15 diet diet NOUN cv43nv9584s 14 16 . . PUNCT cv43nv9584s 15 1 taken take VERB cv43nv9584s 15 2 together together ADV cv43nv9584s 15 3 , , PUNCT cv43nv9584s 15 4 the the DET cv43nv9584s 15 5 isoflavones isoflavone NOUN cv43nv9584s 15 6 are be AUX cv43nv9584s 15 7 able able ADJ cv43nv9584s 15 8 to to PART cv43nv9584s 15 9 affect affect VERB cv43nv9584s 15 10 gene gene NOUN cv43nv9584s 15 11 expression expression NOUN cv43nv9584s 15 12 in in ADP cv43nv9584s 15 13 the the DET cv43nv9584s 15 14 bile bile NOUN cv43nv9584s 15 15 synthetic synthetic ADJ cv43nv9584s 15 16 pathway pathway NOUN cv43nv9584s 15 17 as as ADV cv43nv9584s 15 18 well well ADV cv43nv9584s 15 19 as as ADP cv43nv9584s 15 20 alter alter VERB cv43nv9584s 15 21 the the DET cv43nv9584s 15 22 disposition disposition NOUN cv43nv9584s 15 23 of of ADP cv43nv9584s 15 24 a a DET cv43nv9584s 15 25 lipid lipid NOUN cv43nv9584s 15 26 - - PUNCT cv43nv9584s 15 27 lowering lower VERB cv43nv9584s 15 28 drug drug NOUN cv43nv9584s 15 29 . . PUNCT