id sid tid token lemma pos df65v694z35 1 1 many many ADJ df65v694z35 1 2 complex complex ADJ df65v694z35 1 3 siderophore siderophore NOUN df65v694z35 1 4 conjugates conjugate NOUN df65v694z35 1 5 have have AUX df65v694z35 1 6 been be AUX df65v694z35 1 7 synthesized synthesize VERB df65v694z35 1 8 by by ADP df65v694z35 1 9 the the DET df65v694z35 1 10 miller miller PROPN df65v694z35 1 11 group group NOUN df65v694z35 1 12 and and CCONJ df65v694z35 1 13 others other NOUN df65v694z35 1 14 for for ADP df65v694z35 1 15 the the DET df65v694z35 1 16 purpose purpose NOUN df65v694z35 1 17 of of ADP df65v694z35 1 18 antibiotic antibiotic ADJ df65v694z35 1 19 delivery delivery NOUN df65v694z35 1 20 , , PUNCT df65v694z35 1 21 the the DET df65v694z35 1 22 treatment treatment NOUN df65v694z35 1 23 of of ADP df65v694z35 1 24 iron iron NOUN df65v694z35 1 25 overload overload NOUN df65v694z35 1 26 diseases disease NOUN df65v694z35 1 27 and and CCONJ df65v694z35 1 28 for for ADP df65v694z35 1 29 the the DET df65v694z35 1 30 use use NOUN df65v694z35 1 31 of of ADP df65v694z35 1 32 mri mri NOUN df65v694z35 1 33 contrast contrast NOUN df65v694z35 1 34 agents agent NOUN df65v694z35 1 35 . . PUNCT df65v694z35 2 1 desferrioxamine desferrioxamine PROPN df65v694z35 2 2 b b PROPN df65v694z35 2 3 ( ( PUNCT df65v694z35 2 4 dfo dfo PROPN df65v694z35 2 5 ) ) PUNCT df65v694z35 2 6 , , PUNCT df65v694z35 2 7 a a DET df65v694z35 2 8 commercially commercially ADV df65v694z35 2 9 available available ADJ df65v694z35 2 10 siderophore siderophore NOUN df65v694z35 2 11 , , PUNCT df65v694z35 2 12 has have AUX df65v694z35 2 13 rarely rarely ADV df65v694z35 2 14 been be AUX df65v694z35 2 15 used use VERB df65v694z35 2 16 to to PART df65v694z35 2 17 synthesize synthesize VERB df65v694z35 2 18 such such ADJ df65v694z35 2 19 conjugates conjugate NOUN df65v694z35 2 20 due due ADP df65v694z35 2 21 to to ADP df65v694z35 2 22 the the DET df65v694z35 2 23 complexity complexity NOUN df65v694z35 2 24 of of ADP df65v694z35 2 25 starting start VERB df65v694z35 2 26 from from ADP df65v694z35 2 27 a a DET df65v694z35 2 28 complete complete ADJ df65v694z35 2 29 , , PUNCT df65v694z35 2 30 non non ADJ df65v694z35 2 31 - - ADJ df65v694z35 2 32 protected protected ADJ df65v694z35 2 33 siderophore siderophore NOUN df65v694z35 2 34 . . PUNCT df65v694z35 3 1 the the DET df65v694z35 3 2 methodology methodology NOUN df65v694z35 3 3 needed need VERB df65v694z35 3 4 to to PART df65v694z35 3 5 allow allow VERB df65v694z35 3 6 dfo dfo NOUN df65v694z35 3 7 conjugates conjugate NOUN df65v694z35 3 8 to to PART df65v694z35 3 9 be be AUX df65v694z35 3 10 easily easily ADV df65v694z35 3 11 prepared prepare VERB df65v694z35 3 12 without without ADP df65v694z35 3 13 the the DET df65v694z35 3 14 need need NOUN df65v694z35 3 15 for for ADP df65v694z35 3 16 standard standard ADJ df65v694z35 3 17 protecting protect VERB df65v694z35 3 18 groups group NOUN df65v694z35 3 19 has have AUX df65v694z35 3 20 been be AUX df65v694z35 3 21 discussed discuss VERB df65v694z35 3 22 here here ADV df65v694z35 3 23 . . PUNCT df65v694z35 4 1 a a DET df65v694z35 4 2 dfo dfo NOUN df65v694z35 4 3 - - PUNCT df65v694z35 4 4 ferritin ferritin NOUN df65v694z35 4 5 binding binding ADJ df65v694z35 4 6 peptide peptide NOUN df65v694z35 4 7 conjugate conjugate NOUN df65v694z35 4 8 was be AUX df65v694z35 4 9 synthesized synthesize VERB df65v694z35 4 10 by by ADP df65v694z35 4 11 using use VERB df65v694z35 4 12 fe(iii fe(iii PROPN df65v694z35 4 13 ) ) PUNCT df65v694z35 4 14 as as ADP df65v694z35 4 15 a a DET df65v694z35 4 16 protecting protect VERB df65v694z35 4 17 group group NOUN df65v694z35 4 18 . . PUNCT df65v694z35 5 1 using use VERB df65v694z35 5 2 a a DET df65v694z35 5 3 ph ph NOUN df65v694z35 5 4 controlled control VERB df65v694z35 5 5 edc edc PROPN df65v694z35 5 6 coupling coupling NOUN df65v694z35 5 7 reaction reaction NOUN df65v694z35 5 8 , , PUNCT df65v694z35 5 9 selective selective ADJ df65v694z35 5 10 reaction reaction NOUN df65v694z35 5 11 at at ADP df65v694z35 5 12 the the DET df65v694z35 5 13 terminal terminal ADJ df65v694z35 5 14 serine serine NOUN df65v694z35 5 15 of of ADP df65v694z35 5 16 the the DET df65v694z35 5 17 ferritin ferritin NOUN df65v694z35 5 18 binding bind VERB df65v694z35 5 19 peptide peptide NOUN df65v694z35 5 20 versus versus ADP df65v694z35 5 21 the the DET df65v694z35 5 22 internal internal ADJ df65v694z35 5 23 lysine lysine NOUN df65v694z35 5 24 of of ADP df65v694z35 5 25 the the DET df65v694z35 5 26 peptide peptide NOUN df65v694z35 5 27 was be AUX df65v694z35 5 28 facilitated facilitate VERB df65v694z35 5 29 . . PUNCT df65v694z35 6 1 the the DET df65v694z35 6 2 dfo dfo NOUN df65v694z35 6 3 - - PUNCT df65v694z35 6 4 peptide peptide NOUN df65v694z35 6 5 conjugate conjugate NOUN df65v694z35 6 6 was be AUX df65v694z35 6 7 found find VERB df65v694z35 6 8 to to PART df65v694z35 6 9 increase increase VERB df65v694z35 6 10 the the DET df65v694z35 6 11 demineralization demineralization NOUN df65v694z35 6 12 of of ADP df65v694z35 6 13 ferritin ferritin NOUN df65v694z35 6 14 by by ADP df65v694z35 6 15 8 8 NUM df65v694z35 6 16 - - PUNCT df65v694z35 6 17 times time NOUN df65v694z35 6 18 . . PUNCT df65v694z35 7 1 after after ADP df65v694z35 7 2 the the DET df65v694z35 7 3 synthesis synthesis NOUN df65v694z35 7 4 of of ADP df65v694z35 7 5 the the DET df65v694z35 7 6 first first ADJ df65v694z35 7 7 peptide peptide NOUN df65v694z35 7 8 conjugate conjugate NOUN df65v694z35 7 9 a a DET df65v694z35 7 10 scaled scale VERB df65v694z35 7 11 up up ADP df65v694z35 7 12 synthesis synthesis NOUN df65v694z35 7 13 was be AUX df65v694z35 7 14 designed design VERB df65v694z35 7 15 to to PART df65v694z35 7 16 provide provide VERB df65v694z35 7 17 enough enough ADJ df65v694z35 7 18 conjugate conjugate NOUN df65v694z35 7 19 for for ADP df65v694z35 7 20 in in ADP df65v694z35 7 21 vivo vivo ADJ df65v694z35 7 22 testing testing NOUN df65v694z35 7 23 in in ADP df65v694z35 7 24 mice mouse NOUN df65v694z35 7 25 . . PUNCT df65v694z35 8 1 a a DET df65v694z35 8 2 maleimide maleimide ADJ df65v694z35 8 3 linker linker NOUN df65v694z35 8 4 containing contain VERB df65v694z35 8 5 dfo dfo PROPN df65v694z35 8 6 derivative derivative NOUN df65v694z35 8 7 was be AUX df65v694z35 8 8 synthesized synthesize VERB df65v694z35 8 9 . . PUNCT df65v694z35 9 1 a a DET df65v694z35 9 2 second second ADJ df65v694z35 9 3 dfo dfo NOUN df65v694z35 9 4 - - PUNCT df65v694z35 9 5 ferritin ferritin NOUN df65v694z35 9 6 binding bind VERB df65v694z35 9 7 peptide peptide NOUN df65v694z35 9 8 conjugate conjugate NOUN df65v694z35 9 9 was be AUX df65v694z35 9 10 synthesized synthesize VERB df65v694z35 9 11 using use VERB df65v694z35 9 12 a a DET df65v694z35 9 13 thiol thiol PROPN df65v694z35 9 14 maleimide maleimide PROPN df65v694z35 9 15 michael michael PROPN df65v694z35 9 16 reaction reaction NOUN df65v694z35 9 17 as as ADP df65v694z35 9 18 the the DET df65v694z35 9 19 key key ADJ df65v694z35 9 20 conjugation conjugation NOUN df65v694z35 9 21 step step NOUN df65v694z35 9 22 . . PUNCT df65v694z35 10 1 preliminary preliminary ADJ df65v694z35 10 2 results result NOUN df65v694z35 10 3 indicate indicate VERB df65v694z35 10 4 the the DET df65v694z35 10 5 dfo dfo NOUN df65v694z35 10 6 - - PUNCT df65v694z35 10 7 peptide peptide NOUN df65v694z35 10 8 conjugate conjugate NOUN df65v694z35 10 9 does do AUX df65v694z35 10 10 not not PART df65v694z35 10 11 increase increase VERB df65v694z35 10 12 iron iron NOUN df65v694z35 10 13 excretion.a excretion.a PROPN df65v694z35 10 14 dfo dfo PROPN df65v694z35 10 15 - - PUNCT df65v694z35 10 16 dual dual ADJ df65v694z35 10 17 action action NOUN df65v694z35 10 18 cephalosporin cephalosporin NOUN df65v694z35 10 19 conjugated conjugate VERB df65v694z35 10 20 was be AUX df65v694z35 10 21 designed design VERB df65v694z35 10 22 which which PRON df65v694z35 10 23 would would AUX df65v694z35 10 24 also also ADV df65v694z35 10 25 use use VERB df65v694z35 10 26 a a DET df65v694z35 10 27 thiol thiol PROPN df65v694z35 10 28 maleimide maleimide ADJ df65v694z35 10 29 michael michael PROPN df65v694z35 10 30 reaction reaction NOUN df65v694z35 10 31 for for ADP df65v694z35 10 32 the the DET df65v694z35 10 33 key key ADJ df65v694z35 10 34 conjugation conjugation NOUN df65v694z35 10 35 step step NOUN df65v694z35 10 36 . . PUNCT df65v694z35 11 1 a a DET df65v694z35 11 2 dual dual ADJ df65v694z35 11 3 action action NOUN df65v694z35 11 4 cephalosporin cephalosporin NOUN df65v694z35 11 5 ( ( PUNCT df65v694z35 11 6 dac dac PROPN df65v694z35 11 7 ) ) PUNCT df65v694z35 11 8 releases release VERB df65v694z35 11 9 a a DET df65v694z35 11 10 drug drug NOUN df65v694z35 11 11 when when SCONJ df65v694z35 11 12 attacked attack VERB df65v694z35 11 13 at at ADP df65v694z35 11 14 the the DET df65v694z35 11 15 ìøå¢-lactam ìøå¢-lactam NOUN df65v694z35 11 16 ring ring NOUN df65v694z35 11 17 . . PUNCT df65v694z35 12 1 although although SCONJ df65v694z35 12 2 the the DET df65v694z35 12 3 final final ADJ df65v694z35 12 4 conjugation conjugation NOUN df65v694z35 12 5 step step NOUN df65v694z35 12 6 had have AUX df65v694z35 12 7 been be AUX df65v694z35 12 8 worked work VERB df65v694z35 12 9 out out ADP df65v694z35 12 10 , , PUNCT df65v694z35 12 11 the the DET df65v694z35 12 12 synthesis synthesis NOUN df65v694z35 12 13 of of ADP df65v694z35 12 14 the the DET df65v694z35 12 15 cephalosporin cephalosporin NOUN df65v694z35 12 16 portion portion NOUN df65v694z35 12 17 of of ADP df65v694z35 12 18 the the DET df65v694z35 12 19 dfo dfo PROPN df65v694z35 12 20 - - PUNCT df65v694z35 12 21 dac dac NOUN df65v694z35 12 22 conjugate conjugate NOUN df65v694z35 12 23 had have VERB df65v694z35 12 24 not not PART df65v694z35 12 25 . . PUNCT df65v694z35 13 1 work work VERB df65v694z35 13 2 toward toward ADP df65v694z35 13 3 the the DET df65v694z35 13 4 cephalosporin cephalosporin NOUN df65v694z35 13 5 portion portion NOUN df65v694z35 13 6 of of ADP df65v694z35 13 7 the the DET df65v694z35 13 8 conjugate conjugate NOUN df65v694z35 13 9 led lead VERB df65v694z35 13 10 to to ADP df65v694z35 13 11 the the DET df65v694z35 13 12 development development NOUN df65v694z35 13 13 of of ADP df65v694z35 13 14 a a DET df65v694z35 13 15 method method NOUN df65v694z35 13 16 to to PART df65v694z35 13 17 deacetylate deacetylate VERB df65v694z35 13 18 an an DET df65v694z35 13 19 acid acid NOUN df65v694z35 13 20 protected protect VERB df65v694z35 13 21 cephalosporin cephalosporin NOUN df65v694z35 13 22 . . PUNCT df65v694z35 14 1 the the DET df65v694z35 14 2 final final ADJ df65v694z35 14 3 dfo dfo PROPN df65v694z35 14 4 - - PUNCT df65v694z35 14 5 dac dac NOUN df65v694z35 14 6 conjugate conjugate NOUN df65v694z35 14 7 was be AUX df65v694z35 14 8 not not PART df65v694z35 14 9 obtained obtain VERB df65v694z35 14 10 due due ADJ df65v694z35 14 11 to to ADP df65v694z35 14 12 the the DET df65v694z35 14 13 inability inability NOUN df65v694z35 14 14 to to PART df65v694z35 14 15 remove remove VERB df65v694z35 14 16 the the DET df65v694z35 14 17 cephalosporin cephalosporin NOUN df65v694z35 14 18 protecting protect VERB df65v694z35 14 19 groups group NOUN df65v694z35 14 20 . . PUNCT df65v694z35 15 1 further further ADJ df65v694z35 15 2 development development NOUN df65v694z35 15 3 of of ADP df65v694z35 15 4 the the DET df65v694z35 15 5 methodology methodology NOUN df65v694z35 15 6 reported report VERB df65v694z35 15 7 , , PUNCT df65v694z35 15 8 however however ADV df65v694z35 15 9 , , PUNCT df65v694z35 15 10 is be AUX df65v694z35 15 11 anticipated anticipate VERB df65v694z35 15 12 to to PART df65v694z35 15 13 provide provide VERB df65v694z35 15 14 an an DET df65v694z35 15 15 opportunity opportunity NOUN df65v694z35 15 16 for for ADP df65v694z35 15 17 the the DET df65v694z35 15 18 discovery discovery NOUN df65v694z35 15 19 of of ADP df65v694z35 15 20 new new ADJ df65v694z35 15 21 , , PUNCT df65v694z35 15 22 selective selective ADJ df65v694z35 15 23 antibiotics antibiotic NOUN df65v694z35 15 24 and and CCONJ df65v694z35 15 25 diagnostic diagnostic ADJ df65v694z35 15 26 agents agent NOUN df65v694z35 15 27 . . PUNCT