id sid tid token lemma pos df65v696391 1 1 our our PRON df65v696391 1 2 laboratory laboratory NOUN df65v696391 1 3 has have AUX df65v696391 1 4 utilized utilize VERB df65v696391 1 5 total total ADJ df65v696391 1 6 synthesis synthesis NOUN df65v696391 1 7 , , PUNCT df65v696391 1 8 semi semi ADJ df65v696391 1 9 - - NOUN df65v696391 1 10 synthesis synthesis NOUN df65v696391 1 11 , , PUNCT df65v696391 1 12 and and CCONJ df65v696391 1 13 fermentation fermentation NOUN df65v696391 1 14 of of ADP df65v696391 1 15 bacterial bacterial ADJ df65v696391 1 16 species specie NOUN df65v696391 1 17 to to PART df65v696391 1 18 produce produce VERB df65v696391 1 19 natural natural ADJ df65v696391 1 20 product product NOUN df65v696391 1 21 analogs analog NOUN df65v696391 1 22 to to PART df65v696391 1 23 study study VERB df65v696391 1 24 the the DET df65v696391 1 25 relationship relationship NOUN df65v696391 1 26 between between ADP df65v696391 1 27 conformational conformational ADJ df65v696391 1 28 preferences preference NOUN df65v696391 1 29 and and CCONJ df65v696391 1 30 biological biological ADJ df65v696391 1 31 activity activity NOUN df65v696391 1 32 . . PUNCT df65v696391 2 1 our our PRON df65v696391 2 2 goal goal NOUN df65v696391 2 3 is be AUX df65v696391 2 4 to to PART df65v696391 2 5 show show VERB df65v696391 2 6 the the DET df65v696391 2 7 importance importance NOUN df65v696391 2 8 of of ADP df65v696391 2 9 the the DET df65v696391 2 10 conformational conformational ADJ df65v696391 2 11 characteristics characteristic NOUN df65v696391 2 12 of of ADP df65v696391 2 13 natural natural ADJ df65v696391 2 14 products product NOUN df65v696391 2 15 in in ADP df65v696391 2 16 the the DET df65v696391 2 17 development development NOUN df65v696391 2 18 of of ADP df65v696391 2 19 potential potential ADJ df65v696391 2 20 therapeutics therapeutic NOUN df65v696391 2 21 , , PUNCT df65v696391 2 22 features feature VERB df65v696391 2 23 that that PRON df65v696391 2 24 are be AUX df65v696391 2 25 commonly commonly ADV df65v696391 2 26 disregarded disregard VERB df65v696391 2 27 in in ADP df65v696391 2 28 structure structure NOUN df65v696391 2 29 - - PUNCT df65v696391 2 30 activity activity NOUN df65v696391 2 31 relationship relationship NOUN df65v696391 2 32 studies.a studies.a PROPN df65v696391 2 33 new new ADJ df65v696391 2 34 linear linear PROPN df65v696391 2 35 analog analog NOUN df65v696391 2 36 for for ADP df65v696391 2 37 zampanolide zampanolide PROPN df65v696391 2 38 , , PUNCT df65v696391 2 39 a a DET df65v696391 2 40 macrolide macrolide NOUN df65v696391 2 41 extracted extract VERB df65v696391 2 42 from from ADP df65v696391 2 43 the the DET df65v696391 2 44 marine marine ADJ df65v696391 2 45 sponge sponge NOUN df65v696391 2 46 faciospongia faciospongia PROPN df65v696391 2 47 rimosa rimosa PROPN df65v696391 2 48 ; ; PUNCT df65v696391 2 49 and and CCONJ df65v696391 2 50 new new ADJ df65v696391 2 51 diene diene NOUN df65v696391 2 52 analogs analog NOUN df65v696391 2 53 for for ADP df65v696391 2 54 gex1a gex1a PROPN df65v696391 2 55 , , PUNCT df65v696391 2 56 a a DET df65v696391 2 57 compound compound NOUN df65v696391 2 58 isolated isolate VERB df65v696391 2 59 from from ADP df65v696391 2 60 streptomyces streptomyce NOUN df65v696391 2 61 chromofuscus chromofuscus PROPN df65v696391 2 62 , , PUNCT df65v696391 2 63 were be AUX df65v696391 2 64 synthesized synthesize VERB df65v696391 2 65 . . PUNCT df65v696391 3 1 their their PRON df65v696391 3 2 conformational conformational ADJ df65v696391 3 3 preferences preference NOUN df65v696391 3 4 were be AUX df65v696391 3 5 predicted predict VERB df65v696391 3 6 with with ADP df65v696391 3 7 computational computational ADJ df65v696391 3 8 methods method NOUN df65v696391 3 9 and and CCONJ df65v696391 3 10 corroborated corroborate VERB df65v696391 3 11 by by ADP df65v696391 3 12 nuclear nuclear ADJ df65v696391 3 13 magnetic magnetic ADJ df65v696391 3 14 resonance resonance NOUN df65v696391 3 15 experiments experiment NOUN df65v696391 3 16 . . PUNCT df65v696391 4 1 the the DET df65v696391 4 2 biological biological ADJ df65v696391 4 3 activity activity NOUN df65v696391 4 4 of of ADP df65v696391 4 5 the the DET df65v696391 4 6 new new ADJ df65v696391 4 7 compounds compound NOUN df65v696391 4 8 was be AUX df65v696391 4 9 tested test VERB df65v696391 4 10 on on ADP df65v696391 4 11 cancer cancer NOUN df65v696391 4 12 cell cell NOUN df65v696391 4 13 lines line NOUN df65v696391 4 14 , , PUNCT df65v696391 4 15 which which PRON df65v696391 4 16 allowed allow VERB df65v696391 4 17 us we PRON df65v696391 4 18 to to PART df65v696391 4 19 assess assess VERB df65v696391 4 20 if if SCONJ df65v696391 4 21 the the DET df65v696391 4 22 initial initial ADJ df65v696391 4 23 hypotheses hypothesis NOUN df65v696391 4 24 were be AUX df65v696391 4 25 valid valid ADJ df65v696391 4 26 . . PUNCT df65v696391 5 1 in in ADP df65v696391 5 2 the the DET df65v696391 5 3 case case NOUN df65v696391 5 4 of of ADP df65v696391 5 5 zampanolide zampanolide PROPN df65v696391 5 6 , , PUNCT df65v696391 5 7 it it PRON df65v696391 5 8 was be AUX df65v696391 5 9 demonstrated demonstrate VERB df65v696391 5 10 that that SCONJ df65v696391 5 11 the the DET df65v696391 5 12 linear linear PROPN df65v696391 5 13 analog analog NOUN df65v696391 5 14 exhibited exhibit VERB df65v696391 5 15 potent potent ADJ df65v696391 5 16 biological biological ADJ df65v696391 5 17 activity activity NOUN df65v696391 5 18 due due ADP df65v696391 5 19 to to ADP df65v696391 5 20 the the DET df65v696391 5 21 conservation conservation NOUN df65v696391 5 22 of of ADP df65v696391 5 23 an an DET df65v696391 5 24 allylic allylic ADJ df65v696391 5 25 strain strain NOUN df65v696391 5 26 , , PUNCT df65v696391 5 27 which which PRON df65v696391 5 28 restricted restrict VERB df65v696391 5 29 the the DET df65v696391 5 30 conformational conformational ADJ df65v696391 5 31 flexibility flexibility NOUN df65v696391 5 32 of of ADP df65v696391 5 33 the the DET df65v696391 5 34 molecule molecule NOUN df65v696391 5 35 . . PUNCT df65v696391 6 1 for for ADP df65v696391 6 2 gex1a gex1a PROPN df65v696391 6 3 , , PUNCT df65v696391 6 4 it it PRON df65v696391 6 5 was be AUX df65v696391 6 6 shown show VERB df65v696391 6 7 that that SCONJ df65v696391 6 8 an an DET df65v696391 6 9 increase increase NOUN df65v696391 6 10 in in ADP df65v696391 6 11 the the DET df65v696391 6 12 population population NOUN df65v696391 6 13 of of ADP df65v696391 6 14 the the DET df65v696391 6 15 main main ADJ df65v696391 6 16 conformational conformational ADJ df65v696391 6 17 family family NOUN df65v696391 6 18 did do AUX df65v696391 6 19 not not PART df65v696391 6 20 lead lead VERB df65v696391 6 21 to to ADP df65v696391 6 22 enhanced enhance VERB df65v696391 6 23 bioactivity.additionally bioactivity.additionally ADV df65v696391 6 24 , , PUNCT df65v696391 6 25 an an DET df65v696391 6 26 introduction introduction NOUN df65v696391 6 27 to to ADP df65v696391 6 28 machine machine NOUN df65v696391 6 29 learning learning NOUN df65v696391 6 30 and and CCONJ df65v696391 6 31 some some DET df65v696391 6 32 examples example NOUN df65v696391 6 33 of of ADP df65v696391 6 34 its its PRON df65v696391 6 35 use use NOUN df65v696391 6 36 in in ADP df65v696391 6 37 organic organic ADJ df65v696391 6 38 chemistry chemistry NOUN df65v696391 6 39 is be AUX df65v696391 6 40 given give VERB df65v696391 6 41 . . PUNCT df65v696391 7 1 this this PRON df65v696391 7 2 is be AUX df65v696391 7 3 in in ADP df65v696391 7 4 light light NOUN df65v696391 7 5 of of ADP df65v696391 7 6 the the DET df65v696391 7 7 work work NOUN df65v696391 7 8 done do VERB df65v696391 7 9 in in ADP df65v696391 7 10 iridium iridium NOUN df65v696391 7 11 - - PUNCT df65v696391 7 12 catalyzed catalyze VERB df65v696391 7 13 hydrogen hydrogen NOUN df65v696391 7 14 isotope isotope PROPN df65v696391 7 15 exchange exchange NOUN df65v696391 7 16 reactions reaction NOUN df65v696391 7 17 , , PUNCT df65v696391 7 18 that that PRON df65v696391 7 19 was be AUX df65v696391 7 20 performed perform VERB df65v696391 7 21 during during ADP df65v696391 7 22 a a DET df65v696391 7 23 six six NUM df65v696391 7 24 - - PUNCT df65v696391 7 25 month month NOUN df65v696391 7 26 internship internship NOUN df65v696391 7 27 at at ADP df65v696391 7 28 the the DET df65v696391 7 29 catalysis catalysis NOUN df65v696391 7 30 group group NOUN df65v696391 7 31 in in ADP df65v696391 7 32 merck merck PROPN df65v696391 7 33 . . PUNCT df65v696391 8 1 high high ADJ df65v696391 8 2 throughput throughput NOUN df65v696391 8 3 experimentation experimentation NOUN df65v696391 8 4 was be AUX df65v696391 8 5 used use VERB df65v696391 8 6 to to PART df65v696391 8 7 create create VERB df65v696391 8 8 a a DET df65v696391 8 9 large large ADJ df65v696391 8 10 dataset dataset NOUN df65v696391 8 11 to to PART df65v696391 8 12 train train VERB df65v696391 8 13 a a DET df65v696391 8 14 machine machine NOUN df65v696391 8 15 learning learning NOUN df65v696391 8 16 model model NOUN df65v696391 8 17 , , PUNCT df65v696391 8 18 that that PRON df65v696391 8 19 predicted predict VERB df65v696391 8 20 the the DET df65v696391 8 21 deuterium deuterium NOUN df65v696391 8 22 incorporation incorporation NOUN df65v696391 8 23 on on ADP df65v696391 8 24 drug drug NOUN df65v696391 8 25 - - PUNCT df65v696391 8 26 like like ADJ df65v696391 8 27 molecules molecule NOUN df65v696391 8 28 . . PUNCT df65v696391 9 1 this this DET df65v696391 9 2 model model NOUN df65v696391 9 3 is be AUX df65v696391 9 4 now now ADV df65v696391 9 5 being be AUX df65v696391 9 6 used use VERB df65v696391 9 7 and and CCONJ df65v696391 9 8 optimized optimize VERB df65v696391 9 9 on on ADP df65v696391 9 10 pipeline pipeline NOUN df65v696391 9 11 projects project NOUN df65v696391 9 12 at at ADP df65v696391 9 13 merck merck NOUN df65v696391 9 14 . . PUNCT