id	sid	tid	token	lemma	pos
dn39x061h4p	1	1	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	1	2	3'-phosphotransferases	3'-phosphotransferases	NUM
dn39x061h4p	1	3	[	[	X
dn39x061h4p	1	4	aph(3')s	aph(3')s	X
dn39x061h4p	1	5	]	]	X
dn39x061h4p	1	6	are	be	AUX
dn39x061h4p	1	7	important	important	ADJ
dn39x061h4p	1	8	bacterial	bacterial	ADJ
dn39x061h4p	1	9	resistance	resistance	NOUN
dn39x061h4p	1	10	enzymes	enzyme	NOUN
dn39x061h4p	1	11	for	for	ADP
dn39x061h4p	1	12	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	1	13	antibiotics	antibiotic	NOUN
dn39x061h4p	1	14	.	.	PUNCT
dn39x061h4p	2	1	these	these	DET
dn39x061h4p	2	2	enzymes	enzyme	NOUN
dn39x061h4p	2	3	transfer	transfer	VERB
dn39x061h4p	2	4	the	the	DET
dn39x061h4p	2	5	phosphoryl	phosphoryl	NOUN
dn39x061h4p	2	6	group	group	PROPN
dn39x061h4p	2	7	of	of	ADP
dn39x061h4p	2	8	atp	atp	PROPN
dn39x061h4p	2	9	to	to	ADP
dn39x061h4p	2	10	the	the	DET
dn39x061h4p	2	11	3'-hydroxyl	3'-hydroxyl	NUM
dn39x061h4p	2	12	of	of	ADP
dn39x061h4p	2	13	the	the	DET
dn39x061h4p	2	14	antibiotics	antibiotic	NOUN
dn39x061h4p	2	15	.	.	PUNCT
dn39x061h4p	3	1	quench	quench	NOUN
dn39x061h4p	3	2	-	-	PUNCT
dn39x061h4p	3	3	flow	flow	NOUN
dn39x061h4p	3	4	pre	pre	ADJ
dn39x061h4p	3	5	-	-	ADJ
dn39x061h4p	3	6	steady	steady	ADJ
dn39x061h4p	3	7	-	-	PUNCT
dn39x061h4p	3	8	state	state	NOUN
dn39x061h4p	3	9	kinetic	kinetic	NOUN
dn39x061h4p	3	10	analyses	analysis	NOUN
dn39x061h4p	3	11	of	of	ADP
dn39x061h4p	3	12	the	the	DET
dn39x061h4p	3	13	reactions	reaction	NOUN
dn39x061h4p	3	14	of	of	ADP
dn39x061h4p	3	15	gram	gram	NOUN
dn39x061h4p	3	16	-	-	PUNCT
dn39x061h4p	3	17	negative	negative	ADJ
dn39x061h4p	3	18	aph(3	aph(3	SPACE
dn39x061h4p	3	19	'	'	PUNCT
dn39x061h4p	3	20	)	)	PUNCT
dn39x061h4p	3	21	types	type	NOUN
dn39x061h4p	3	22	ia	ia	PROPN
dn39x061h4p	3	23	and	and	CCONJ
dn39x061h4p	3	24	iia	iia	PROPN
dn39x061h4p	3	25	were	be	AUX
dn39x061h4p	3	26	carried	carry	VERB
dn39x061h4p	3	27	out	out	ADP
dn39x061h4p	3	28	with	with	ADP
dn39x061h4p	3	29	kanamycin	kanamycin	PROPN
dn39x061h4p	3	30	a	a	DET
dn39x061h4p	3	31	,	,	PUNCT
dn39x061h4p	3	32	neamine	neamine	ADJ
dn39x061h4p	3	33	,	,	PUNCT
dn39x061h4p	3	34	their	their	PRON
dn39x061h4p	3	35	respective	respective	ADJ
dn39x061h4p	3	36	difluorinated	difluorinate	VERB
dn39x061h4p	3	37	analogues	analogue	NOUN
dn39x061h4p	3	38	and	and	CCONJ
dn39x061h4p	3	39	d198a	d198a	ADV
dn39x061h4p	3	40	mutant	mutant	ADJ
dn39x061h4p	3	41	aph(3')-ia	aph(3')-ia	PROPN
dn39x061h4p	3	42	,	,	PUNCT
dn39x061h4p	3	43	in	in	ADP
dn39x061h4p	3	44	conjunction	conjunction	NOUN
dn39x061h4p	3	45	with	with	ADP
dn39x061h4p	3	46	measurements	measurement	NOUN
dn39x061h4p	3	47	of	of	ADP
dn39x061h4p	3	48	thio	thio	NOUN
dn39x061h4p	3	49	effects	effect	NOUN
dn39x061h4p	3	50	and	and	CCONJ
dn39x061h4p	3	51	solvent	solvent	ADJ
dn39x061h4p	3	52	viscosity	viscosity	NOUN
dn39x061h4p	3	53	effects	effect	NOUN
dn39x061h4p	3	54	to	to	PART
dn39x061h4p	3	55	shed	shed	VERB
dn39x061h4p	3	56	light	light	NOUN
dn39x061h4p	3	57	on	on	ADP
dn39x061h4p	3	58	the	the	DET
dn39x061h4p	3	59	details	detail	NOUN
dn39x061h4p	3	60	of	of	ADP
dn39x061h4p	3	61	the	the	DET
dn39x061h4p	3	62	turnover	turnover	NOUN
dn39x061h4p	3	63	chemistry	chemistry	NOUN
dn39x061h4p	3	64	.	.	PUNCT
dn39x061h4p	4	1	the	the	DET
dn39x061h4p	4	2	fluorinated	fluorinate	VERB
dn39x061h4p	4	3	analogues	analogue	NOUN
dn39x061h4p	4	4	were	be	AUX
dn39x061h4p	4	5	shown	show	VERB
dn39x061h4p	4	6	to	to	PART
dn39x061h4p	4	7	be	be	AUX
dn39x061h4p	4	8	severely	severely	ADV
dn39x061h4p	4	9	impaired	impair	VERB
dn39x061h4p	4	10	as	as	ADP
dn39x061h4p	4	11	substrates	substrate	NOUN
dn39x061h4p	4	12	for	for	ADP
dn39x061h4p	4	13	these	these	DET
dn39x061h4p	4	14	enzymes	enzyme	NOUN
dn39x061h4p	4	15	.	.	PUNCT
dn39x061h4p	5	1	the	the	DET
dn39x061h4p	5	2	magnitude	magnitude	NOUN
dn39x061h4p	5	3	of	of	ADP
dn39x061h4p	5	4	the	the	DET
dn39x061h4p	5	5	effect	effect	NOUN
dn39x061h4p	5	6	of	of	ADP
dn39x061h4p	5	7	the	the	DET
dn39x061h4p	5	8	impairment	impairment	NOUN
dn39x061h4p	5	9	of	of	ADP
dn39x061h4p	5	10	the	the	DET
dn39x061h4p	5	11	fluorinated	fluorinate	VERB
dn39x061h4p	5	12	substrates	substrate	NOUN
dn39x061h4p	5	13	was	be	AUX
dn39x061h4p	5	14	in	in	ADP
dn39x061h4p	5	15	the	the	DET
dn39x061h4p	5	16	same	same	ADJ
dn39x061h4p	5	17	range	range	NOUN
dn39x061h4p	5	18	as	as	SCONJ
dn39x061h4p	5	19	when	when	SCONJ
dn39x061h4p	5	20	the	the	DET
dn39x061h4p	5	21	d198a	d198a	ADV
dn39x061h4p	5	22	mutant	mutant	ADJ
dn39x061h4p	5	23	aph(3')-ia	aph(3')-ia	NOUN
dn39x061h4p	5	24	was	be	AUX
dn39x061h4p	5	25	studied	study	VERB
dn39x061h4p	5	26	with	with	ADP
dn39x061h4p	5	27	non	non	ADJ
dn39x061h4p	5	28	-	-	ADJ
dn39x061h4p	5	29	fluorinated	fluorinated	ADJ
dn39x061h4p	5	30	substrates	substrate	NOUN
dn39x061h4p	5	31	.	.	PUNCT
dn39x061h4p	6	1	residue	residue	NOUN
dn39x061h4p	6	2	198	198	NUM
dn39x061h4p	6	3	is	be	AUX
dn39x061h4p	6	4	the	the	DET
dn39x061h4p	6	5	proposed	propose	VERB
dn39x061h4p	6	6	general	general	ADJ
dn39x061h4p	6	7	base	base	NOUN
dn39x061h4p	6	8	that	that	PRON
dn39x061h4p	6	9	promotes	promote	VERB
dn39x061h4p	6	10	the	the	DET
dn39x061h4p	6	11	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	6	12	hydroxyl	hydroxyl	PROPN
dn39x061h4p	6	13	for	for	ADP
dn39x061h4p	6	14	phosphorylation	phosphorylation	NOUN
dn39x061h4p	6	15	.	.	PUNCT
dn39x061h4p	7	1	these	these	DET
dn39x061h4p	7	2	findings	finding	NOUN
dn39x061h4p	7	3	collectively	collectively	ADV
dn39x061h4p	7	4	argue	argue	VERB
dn39x061h4p	7	5	that	that	SCONJ
dn39x061h4p	7	6	the	the	DET
dn39x061h4p	7	7	gram	gram	NOUN
dn39x061h4p	7	8	-	-	PUNCT
dn39x061h4p	7	9	negative	negative	ADJ
dn39x061h4p	7	10	aph(3')s	aph(3')s	NOUN
dn39x061h4p	7	11	show	show	VERB
dn39x061h4p	7	12	significant	significant	ADJ
dn39x061h4p	7	13	nucleophile	nucleophile	ADJ
dn39x061h4p	7	14	participation	participation	NOUN
dn39x061h4p	7	15	in	in	ADP
dn39x061h4p	7	16	the	the	DET
dn39x061h4p	7	17	transition	transition	NOUN
dn39x061h4p	7	18	state	state	NOUN
dn39x061h4p	7	19	for	for	ADP
dn39x061h4p	7	20	the	the	DET
dn39x061h4p	7	21	phosphate	phosphate	NOUN
dn39x061h4p	7	22	transfer	transfer	NOUN
dn39x061h4p	7	23	reaction	reaction	NOUN
dn39x061h4p	7	24	.	.	PUNCT
dn39x061h4p	8	1	pre	pre	ADJ
dn39x061h4p	8	2	-	-	ADJ
dn39x061h4p	8	3	steady	steady	ADJ
dn39x061h4p	8	4	-	-	PUNCT
dn39x061h4p	8	5	state	state	NOUN
dn39x061h4p	8	6	kinetics	kinetic	NOUN
dn39x061h4p	8	7	demonstrated	demonstrate	VERB
dn39x061h4p	8	8	that	that	SCONJ
dn39x061h4p	8	9	aph(3')-ia	aph(3')-ia	PROPN
dn39x061h4p	8	10	and	and	CCONJ
dn39x061h4p	8	11	aph(3')-iia	aph(3')-iia	VERB
dn39x061h4p	8	12	in	in	ADP
dn39x061h4p	8	13	both	both	CCONJ
dn39x061h4p	8	14	ternary	ternary	ADJ
dn39x061h4p	8	15	and	and	CCONJ
dn39x061h4p	8	16	binary	binary	ADJ
dn39x061h4p	8	17	complexes	complex	NOUN
dn39x061h4p	8	18	facilitate	facilitate	VERB
dn39x061h4p	8	19	an	an	DET
dn39x061h4p	8	20	atp	atp	ADJ
dn39x061h4p	8	21	hydrolase	hydrolase	NOUN
dn39x061h4p	8	22	activity	activity	NOUN
dn39x061h4p	8	23	(	(	PUNCT
dn39x061h4p	8	24	'	'	PUNCT
dn39x061h4p	8	25	atpase	atpase	NOUN
dn39x061h4p	8	26	'	'	PUNCT
dn39x061h4p	8	27	)	)	PUNCT
dn39x061h4p	8	28	.	.	PUNCT
dn39x061h4p	9	1	since	since	SCONJ
dn39x061h4p	9	2	these	these	DET
dn39x061h4p	9	3	enzymes	enzyme	NOUN
dn39x061h4p	9	4	are	be	AUX
dn39x061h4p	9	5	expressed	express	VERB
dn39x061h4p	9	6	constitutively	constitutively	ADV
dn39x061h4p	9	7	in	in	ADP
dn39x061h4p	9	8	resistant	resistant	ADJ
dn39x061h4p	9	9	bacteria	bacteria	NOUN
dn39x061h4p	9	10	,	,	PUNCT
dn39x061h4p	9	11	the	the	DET
dn39x061h4p	9	12	turnover	turnover	NOUN
dn39x061h4p	9	13	of	of	ADP
dn39x061h4p	9	14	atp	atp	PROPN
dn39x061h4p	9	15	is	be	AUX
dn39x061h4p	9	16	continuous	continuous	ADJ
dn39x061h4p	9	17	during	during	ADP
dn39x061h4p	9	18	the	the	DET
dn39x061h4p	9	19	lifetime	lifetime	NOUN
dn39x061h4p	9	20	of	of	ADP
dn39x061h4p	9	21	the	the	DET
dn39x061h4p	9	22	organism	organism	NOUN
dn39x061h4p	9	23	both	both	CCONJ
dn39x061h4p	9	24	in	in	ADP
dn39x061h4p	9	25	the	the	DET
dn39x061h4p	9	26	absence	absence	NOUN
dn39x061h4p	9	27	and	and	CCONJ
dn39x061h4p	9	28	the	the	DET
dn39x061h4p	9	29	presence	presence	NOUN
dn39x061h4p	9	30	of	of	ADP
dn39x061h4p	9	31	aminoglycosides	aminoglycoside	NOUN
dn39x061h4p	9	32	.	.	PUNCT
dn39x061h4p	10	1	atpase	atpase	ADJ
dn39x061h4p	10	2	activity	activity	NOUN
dn39x061h4p	10	3	would	would	AUX
dn39x061h4p	10	4	potentially	potentially	ADV
dn39x061h4p	10	5	consume	consume	VERB
dn39x061h4p	10	6	as	as	ADV
dn39x061h4p	10	7	much	much	ADJ
dn39x061h4p	10	8	as	as	ADP
dn39x061h4p	10	9	several	several	ADJ
dn39x061h4p	10	10	fold	fold	NOUN
dn39x061h4p	10	11	of	of	ADP
dn39x061h4p	10	12	the	the	DET
dn39x061h4p	10	13	total	total	ADJ
dn39x061h4p	10	14	existing	exist	VERB
dn39x061h4p	10	15	atp	atp	NOUN
dn39x061h4p	10	16	.	.	PUNCT
dn39x061h4p	11	1	studies	study	NOUN
dn39x061h4p	11	2	with	with	ADP
dn39x061h4p	11	3	bacteria	bacteria	NOUN
dn39x061h4p	11	4	harboring	harbor	VERB
dn39x061h4p	11	5	the	the	DET
dn39x061h4p	11	6	aph(3')-ia	aph(3')-ia	PROPN
dn39x061h4p	11	7	gene	gene	NOUN
dn39x061h4p	11	8	revealed	reveal	VERB
dn39x061h4p	11	9	that	that	SCONJ
dn39x061h4p	11	10	bacteria	bacteria	NOUN
dn39x061h4p	11	11	are	be	AUX
dn39x061h4p	11	12	able	able	ADJ
dn39x061h4p	11	13	to	to	PART
dn39x061h4p	11	14	absorb	absorb	VERB
dn39x061h4p	11	15	the	the	DET
dn39x061h4p	11	16	cost	cost	NOUN
dn39x061h4p	11	17	of	of	ADP
dn39x061h4p	11	18	this	this	DET
dn39x061h4p	11	19	atp	atp	ADJ
dn39x061h4p	11	20	turnover	turnover	NOUN
dn39x061h4p	11	21	,	,	PUNCT
dn39x061h4p	11	22	as	as	SCONJ
dn39x061h4p	11	23	atp	atp	PROPN
dn39x061h4p	11	24	is	be	AUX
dn39x061h4p	11	25	recycled	recycle	VERB
dn39x061h4p	11	26	.	.	PUNCT
dn39x061h4p	12	1	however	however	ADV
dn39x061h4p	12	2	,	,	PUNCT
dn39x061h4p	12	3	the	the	DET
dn39x061h4p	12	4	cost	cost	NOUN
dn39x061h4p	12	5	burden	burden	NOUN
dn39x061h4p	12	6	of	of	ADP
dn39x061h4p	12	7	this	this	DET
dn39x061h4p	12	8	adventitious	adventitious	ADJ
dn39x061h4p	12	9	activity	activity	NOUN
dn39x061h4p	12	10	manifests	manifest	VERB
dn39x061h4p	12	11	a	a	DET
dn39x061h4p	12	12	selection	selection	NOUN
dn39x061h4p	12	13	pressure	pressure	NOUN
dn39x061h4p	12	14	against	against	ADP
dn39x061h4p	12	15	maintenance	maintenance	NOUN
dn39x061h4p	12	16	of	of	ADP
dn39x061h4p	12	17	the	the	DET
dn39x061h4p	12	18	plasmids	plasmid	NOUN
dn39x061h4p	12	19	that	that	PRON
dn39x061h4p	12	20	harbor	harbor	VERB
dn39x061h4p	12	21	the	the	DET
dn39x061h4p	12	22	aph(3')-ia	aph(3')-ia	PROPN
dn39x061h4p	12	23	gene	gene	NOUN
dn39x061h4p	12	24	,	,	PUNCT
dn39x061h4p	12	25	such	such	ADJ
dn39x061h4p	12	26	that	that	SCONJ
dn39x061h4p	12	27	approximately	approximately	ADV
dn39x061h4p	12	28	50	50	NUM
dn39x061h4p	12	29	%	%	NOUN
dn39x061h4p	12	30	of	of	ADP
dn39x061h4p	12	31	the	the	DET
dn39x061h4p	12	32	plasmid	plasmid	NOUN
dn39x061h4p	12	33	is	be	AUX
dn39x061h4p	12	34	lost	lose	VERB
dn39x061h4p	12	35	in	in	ADP
dn39x061h4p	12	36	1500	1500	NUM
dn39x061h4p	12	37	bacterial	bacterial	ADJ
dn39x061h4p	12	38	generations	generation	NOUN
dn39x061h4p	12	39	in	in	ADP
dn39x061h4p	12	40	the	the	DET
dn39x061h4p	12	41	absence	absence	NOUN
dn39x061h4p	12	42	of	of	ADP
dn39x061h4p	12	43	antibiotics	antibiotic	NOUN
dn39x061h4p	12	44	.	.	PUNCT
dn39x061h4p	13	1	the	the	DET
dn39x061h4p	13	2	implication	implication	NOUN
dn39x061h4p	13	3	is	be	AUX
dn39x061h4p	13	4	that	that	PRON
dn39x061h4p	13	5	,	,	PUNCT
dn39x061h4p	13	6	in	in	ADP
dn39x061h4p	13	7	the	the	DET
dn39x061h4p	13	8	absence	absence	NOUN
dn39x061h4p	13	9	of	of	ADP
dn39x061h4p	13	10	selection	selection	NOUN
dn39x061h4p	13	11	,	,	PUNCT
dn39x061h4p	13	12	bacteria	bacteria	NOUN
dn39x061h4p	13	13	harboring	harbor	VERB
dn39x061h4p	13	14	an	an	DET
dn39x061h4p	13	15	enzyme	enzyme	NOUN
dn39x061h4p	13	16	that	that	PRON
dn39x061h4p	13	17	catalyzes	catalyze	VERB
dn39x061h4p	13	18	the	the	DET
dn39x061h4p	13	19	consumption	consumption	NOUN
dn39x061h4p	13	20	of	of	ADP
dn39x061h4p	13	21	key	key	ADJ
dn39x061h4p	13	22	metabolites	metabolite	NOUN
dn39x061h4p	13	23	could	could	AUX
dn39x061h4p	13	24	experience	experience	VERB
dn39x061h4p	13	25	the	the	DET
dn39x061h4p	13	26	loss	loss	NOUN
dn39x061h4p	13	27	of	of	ADP
dn39x061h4p	13	28	the	the	DET
dn39x061h4p	13	29	plasmid	plasmid	NOUN
dn39x061h4p	13	30	that	that	PRON
dn39x061h4p	13	31	encodes	encode	VERB
dn39x061h4p	13	32	for	for	ADP
dn39x061h4p	13	33	the	the	DET
dn39x061h4p	13	34	given	give	VERB
dn39x061h4p	13	35	enzyme.a	enzyme.a	PROPN
dn39x061h4p	13	36	newly	newly	ADV
dn39x061h4p	13	37	discovered	discover	VERB
dn39x061h4p	13	38	bifunctional	bifunctional	ADJ
dn39x061h4p	13	39	antibiotic	antibiotic	ADJ
dn39x061h4p	13	40	resistance	resistance	NOUN
dn39x061h4p	13	41	enzyme	enzyme	NOUN
dn39x061h4p	13	42	(	(	PUNCT
dn39x061h4p	13	43	ant(3')-ii	ant(3')-ii	PROPN
dn39x061h4p	13	44	/	/	SYM
dn39x061h4p	13	45	aac(6')-iid	aac(6')-iid	PROPN
dn39x061h4p	13	46	)	)	PUNCT
dn39x061h4p	13	47	from	from	ADP
dn39x061h4p	13	48	serratia	serratia	NOUN
dn39x061h4p	13	49	marcescens	marcescen	NOUN
dn39x061h4p	13	50	catalyzes	catalyze	VERB
dn39x061h4p	13	51	adenylation	adenylation	NOUN
dn39x061h4p	13	52	of	of	ADP
dn39x061h4p	13	53	streptomycin	streptomycin	PROPN
dn39x061h4p	13	54	and	and	CCONJ
dn39x061h4p	13	55	spectinomycin	spectinomycin	PROPN
dn39x061h4p	13	56	on	on	ADP
dn39x061h4p	13	57	the	the	DET
dn39x061h4p	13	58	3'and	3'and	NUM
dn39x061h4p	13	59	9	9	NUM
dn39x061h4p	13	60	-	-	PUNCT
dn39x061h4p	13	61	hydroxyl	hydroxyl	PROPN
dn39x061h4p	13	62	groups	group	NOUN
dn39x061h4p	13	63	,	,	PUNCT
dn39x061h4p	13	64	respectively	respectively	ADV
dn39x061h4p	13	65	,	,	PUNCT
dn39x061h4p	13	66	and	and	CCONJ
dn39x061h4p	13	67	acetylation	acetylation	NOUN
dn39x061h4p	13	68	of	of	ADP
dn39x061h4p	13	69	kanamycin	kanamycin	PROPN
dn39x061h4p	13	70	a	a	PRON
dn39x061h4p	13	71	on	on	ADP
dn39x061h4p	13	72	the	the	DET
dn39x061h4p	13	73	6'-amine	6'-amine	NUM
dn39x061h4p	13	74	.	.	PUNCT
dn39x061h4p	14	1	the	the	DET
dn39x061h4p	14	2	adenyltransferase	adenyltransferase	NOUN
dn39x061h4p	14	3	domain	domain	NOUN
dn39x061h4p	14	4	appears	appear	VERB
dn39x061h4p	14	5	to	to	PART
dn39x061h4p	14	6	be	be	AUX
dn39x061h4p	14	7	specific	specific	ADJ
dn39x061h4p	14	8	to	to	ADP
dn39x061h4p	14	9	spectinomycin	spectinomycin	PROPN
dn39x061h4p	14	10	and	and	CCONJ
dn39x061h4p	14	11	streptomycin	streptomycin	PROPN
dn39x061h4p	14	12	,	,	PUNCT
dn39x061h4p	14	13	while	while	SCONJ
dn39x061h4p	14	14	the	the	DET
dn39x061h4p	14	15	acetyltransferase	acetyltransferase	NOUN
dn39x061h4p	14	16	domain	domain	NOUN
dn39x061h4p	14	17	shows	show	VERB
dn39x061h4p	14	18	a	a	DET
dn39x061h4p	14	19	broad	broad	ADJ
dn39x061h4p	14	20	substrate	substrate	NOUN
dn39x061h4p	14	21	profile	profile	NOUN
dn39x061h4p	14	22	.	.	PUNCT
dn39x061h4p	15	1	studies	study	NOUN
dn39x061h4p	15	2	using	use	VERB
dn39x061h4p	15	3	initial	initial	ADJ
dn39x061h4p	15	4	velocity	velocity	NOUN
dn39x061h4p	15	5	patterns	pattern	NOUN
dn39x061h4p	15	6	,	,	PUNCT
dn39x061h4p	15	7	dead	dead	ADJ
dn39x061h4p	15	8	-	-	PUNCT
dn39x061h4p	15	9	end	end	NOUN
dn39x061h4p	15	10	and	and	CCONJ
dn39x061h4p	15	11	product	product	NOUN
dn39x061h4p	15	12	inhibitions	inhibition	NOUN
dn39x061h4p	15	13	,	,	PUNCT
dn39x061h4p	15	14	solvent	solvent	ADJ
dn39x061h4p	15	15	isotope	isotope	NOUN
dn39x061h4p	15	16	effects	effect	NOUN
dn39x061h4p	15	17	,	,	PUNCT
dn39x061h4p	15	18	and	and	CCONJ
dn39x061h4p	15	19	solvent	solvent	ADJ
dn39x061h4p	15	20	viscosity	viscosity	NOUN
dn39x061h4p	15	21	effects	effect	NOUN
dn39x061h4p	15	22	reveal	reveal	VERB
dn39x061h4p	15	23	that	that	SCONJ
dn39x061h4p	15	24	adenyltransferase	adenyltransferase	NOUN
dn39x061h4p	15	25	domain	domain	NOUN
dn39x061h4p	15	26	catalyzes	catalyze	VERB
dn39x061h4p	15	27	the	the	DET
dn39x061h4p	15	28	reaction	reaction	NOUN
dn39x061h4p	15	29	by	by	ADP
dn39x061h4p	15	30	a	a	DET
dn39x061h4p	15	31	theorell	theorell	NOUN
dn39x061h4p	15	32	-	-	PUNCT
dn39x061h4p	15	33	chance	chance	NOUN
dn39x061h4p	15	34	kinetic	kinetic	NOUN
dn39x061h4p	15	35	mechanism	mechanism	NOUN
dn39x061h4p	15	36	,	,	PUNCT
dn39x061h4p	15	37	where	where	SCONJ
dn39x061h4p	15	38	atp	atp	PROPN
dn39x061h4p	15	39	binds	bind	VERB
dn39x061h4p	15	40	to	to	ADP
dn39x061h4p	15	41	the	the	DET
dn39x061h4p	15	42	enzyme	enzyme	NOUN
dn39x061h4p	15	43	prior	prior	ADV
dn39x061h4p	15	44	to	to	ADP
dn39x061h4p	15	45	the	the	DET
dn39x061h4p	15	46	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	15	47	and	and	CCONJ
dn39x061h4p	15	48	the	the	DET
dn39x061h4p	15	49	modified	modify	VERB
dn39x061h4p	15	50	antibiotic	antibiotic	NOUN
dn39x061h4p	15	51	is	be	AUX
dn39x061h4p	15	52	the	the	DET
dn39x061h4p	15	53	last	last	ADJ
dn39x061h4p	15	54	product	product	NOUN
dn39x061h4p	15	55	to	to	PART
dn39x061h4p	15	56	be	be	AUX
dn39x061h4p	15	57	released	release	VERB
dn39x061h4p	15	58	.	.	PUNCT
dn39x061h4p	16	1	the	the	DET
dn39x061h4p	16	2	acetyltransferase	acetyltransferase	NOUN
dn39x061h4p	16	3	domain	domain	NOUN
dn39x061h4p	16	4	follows	follow	VERB
dn39x061h4p	16	5	an	an	DET
dn39x061h4p	16	6	ordered	order	VERB
dn39x061h4p	16	7	bi	bi	ADJ
dn39x061h4p	16	8	-	-	ADJ
dn39x061h4p	16	9	bi	bi	ADJ
dn39x061h4p	16	10	kinetic	kinetic	NOUN
dn39x061h4p	16	11	mechanism	mechanism	NOUN
dn39x061h4p	16	12	,	,	PUNCT
dn39x061h4p	16	13	in	in	ADP
dn39x061h4p	16	14	which	which	PRON
dn39x061h4p	16	15	the	the	DET
dn39x061h4p	16	16	antibiotic	antibiotic	NOUN
dn39x061h4p	16	17	is	be	AUX
dn39x061h4p	16	18	the	the	DET
dn39x061h4p	16	19	first	first	ADJ
dn39x061h4p	16	20	substrate	substrate	NOUN
dn39x061h4p	16	21	that	that	PRON
dn39x061h4p	16	22	binds	bind	VERB
dn39x061h4p	16	23	to	to	ADP
dn39x061h4p	16	24	the	the	DET
dn39x061h4p	16	25	active	active	ADJ
dn39x061h4p	16	26	site	site	NOUN
dn39x061h4p	16	27	and	and	CCONJ
dn39x061h4p	16	28	coenzyme	coenzyme	NOUN
dn39x061h4p	16	29	a	a	PRON
dn39x061h4p	16	30	is	be	AUX
dn39x061h4p	16	31	released	release	VERB
dn39x061h4p	16	32	prior	prior	ADV
dn39x061h4p	16	33	to	to	ADP
dn39x061h4p	16	34	the	the	DET
dn39x061h4p	16	35	modified	modify	VERB
dn39x061h4p	16	36	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	16	37	.	.	PUNCT
dn39x061h4p	17	1	another	another	DET
dn39x061h4p	17	2	bifunctional	bifunctional	ADJ
dn39x061h4p	17	3	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	17	4	-	-	PUNCT
dn39x061h4p	17	5	modifying	modify	VERB
dn39x061h4p	17	6	enzyme	enzyme	NOUN
dn39x061h4p	17	7	(	(	PUNCT
dn39x061h4p	17	8	aac(3)-ib	aac(3)-ib	NOUN
dn39x061h4p	17	9	/	/	SYM
dn39x061h4p	17	10	aac(6')-ib	aac(6')-ib	NOUN
dn39x061h4p	17	11	'	'	PUNCT
dn39x061h4p	17	12	)	)	PUNCT
dn39x061h4p	17	13	from	from	ADP
dn39x061h4p	17	14	pseudomonas	pseudomonas	PROPN
dn39x061h4p	17	15	aeruginosa	aeruginosa	PROPN
dn39x061h4p	17	16	catalyzes	catalyze	VERB
dn39x061h4p	17	17	acetylation	acetylation	NOUN
dn39x061h4p	17	18	of	of	ADP
dn39x061h4p	17	19	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	17	20	antibiotics	antibiotic	NOUN
dn39x061h4p	17	21	.	.	PUNCT
dn39x061h4p	18	1	aac(3)-ib	aac(3)-ib	PROPN
dn39x061h4p	18	2	is	be	AUX
dn39x061h4p	18	3	specific	specific	ADJ
dn39x061h4p	18	4	to	to	ADP
dn39x061h4p	18	5	gentamicin	gentamicin	NOUN
dn39x061h4p	18	6	and	and	CCONJ
dn39x061h4p	18	7	fortimicin	fortimicin	VERB
dn39x061h4p	18	8	a	a	PRON
dn39x061h4p	18	9	among	among	ADP
dn39x061h4p	18	10	a	a	DET
dn39x061h4p	18	11	dozen	dozen	NOUN
dn39x061h4p	18	12	of	of	ADP
dn39x061h4p	18	13	aminoglycosides	aminoglycoside	NOUN
dn39x061h4p	18	14	.	.	PUNCT
dn39x061h4p	19	1	initial	initial	ADJ
dn39x061h4p	19	2	velocity	velocity	NOUN
dn39x061h4p	19	3	and	and	CCONJ
dn39x061h4p	19	4	inhibition	inhibition	NOUN
dn39x061h4p	19	5	patterns	pattern	NOUN
dn39x061h4p	19	6	and	and	CCONJ
dn39x061h4p	19	7	the	the	DET
dn39x061h4p	19	8	solvent	solvent	NOUN
dn39x061h4p	19	9	isotope	isotope	NOUN
dn39x061h4p	19	10	effects	effect	NOUN
dn39x061h4p	19	11	indicate	indicate	VERB
dn39x061h4p	19	12	that	that	SCONJ
dn39x061h4p	19	13	aac(3)-ib	aac(3)-ib	NOUN
dn39x061h4p	19	14	catalyzes	catalyze	VERB
dn39x061h4p	19	15	its	its	PRON
dn39x061h4p	19	16	reaction	reaction	NOUN
dn39x061h4p	19	17	through	through	ADP
dn39x061h4p	19	18	an	an	DET
dn39x061h4p	19	19	ordered	order	VERB
dn39x061h4p	19	20	bi	bi	ADJ
dn39x061h4p	19	21	-	-	ADJ
dn39x061h4p	19	22	bi	bi	ADJ
dn39x061h4p	19	23	kinetic	kinetic	NOUN
dn39x061h4p	19	24	mechanism	mechanism	NOUN
dn39x061h4p	19	25	where	where	SCONJ
dn39x061h4p	19	26	acetyl	acetyl	NOUN
dn39x061h4p	19	27	-	-	PUNCT
dn39x061h4p	19	28	coa	coa	NOUN
dn39x061h4p	19	29	binds	bind	VERB
dn39x061h4p	19	30	first	first	ADV
dn39x061h4p	19	31	to	to	ADP
dn39x061h4p	19	32	the	the	DET
dn39x061h4p	19	33	enzyme	enzyme	NOUN
dn39x061h4p	19	34	followed	follow	VERB
dn39x061h4p	19	35	by	by	ADP
dn39x061h4p	19	36	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	19	37	and	and	CCONJ
dn39x061h4p	19	38	the	the	DET
dn39x061h4p	19	39	acetylated	acetylated	ADJ
dn39x061h4p	19	40	aminoglycoside	aminoglycoside	NOUN
dn39x061h4p	19	41	is	be	AUX
dn39x061h4p	19	42	released	release	VERB
dn39x061h4p	19	43	from	from	ADP
dn39x061h4p	19	44	the	the	DET
dn39x061h4p	19	45	active	active	ADJ
dn39x061h4p	19	46	site	site	NOUN
dn39x061h4p	19	47	prior	prior	ADV
dn39x061h4p	19	48	to	to	ADP
dn39x061h4p	19	49	coenzyme	coenzyme	NOUN
dn39x061h4p	19	50	a.	a.	NOUN
dn39x061h4p	20	1	the	the	DET
dn39x061h4p	20	2	solvent	solvent	NOUN
dn39x061h4p	20	3	viscosity	viscosity	NOUN
dn39x061h4p	20	4	effects	effect	NOUN
dn39x061h4p	20	5	suggest	suggest	VERB
dn39x061h4p	20	6	that	that	SCONJ
dn39x061h4p	20	7	the	the	DET
dn39x061h4p	20	8	product	product	NOUN
dn39x061h4p	20	9	release	release	NOUN
dn39x061h4p	20	10	is	be	AUX
dn39x061h4p	20	11	a	a	DET
dn39x061h4p	20	12	rate	rate	NOUN
dn39x061h4p	20	13	-	-	PUNCT
dn39x061h4p	20	14	limiting	limit	VERB
dn39x061h4p	20	15	step	step	NOUN
dn39x061h4p	20	16	in	in	ADP
dn39x061h4p	20	17	catalysis	catalysis	NOUN
dn39x061h4p	20	18	.	.	PUNCT