id sid tid token lemma pos dr26xw45v34 1 1 hematopoietic hematopoietic ADJ dr26xw45v34 1 2 stem stem NOUN dr26xw45v34 1 3 and and CCONJ dr26xw45v34 1 4 progenitor progenitor NOUN dr26xw45v34 1 5 cells cell NOUN dr26xw45v34 1 6 ( ( PUNCT dr26xw45v34 1 7 hspcs hspc NOUN dr26xw45v34 1 8 ) ) PUNCT dr26xw45v34 1 9 make make VERB dr26xw45v34 1 10 up up ADP dr26xw45v34 1 11 the the DET dr26xw45v34 1 12 foundation foundation NOUN dr26xw45v34 1 13 of of ADP dr26xw45v34 1 14 the the DET dr26xw45v34 1 15 blood blood NOUN dr26xw45v34 1 16 hierarchy hierarchy NOUN dr26xw45v34 1 17 . . PUNCT dr26xw45v34 2 1 hspcs hspc NOUN dr26xw45v34 2 2 differentiate differentiate VERB dr26xw45v34 2 3 down down ADP dr26xw45v34 2 4 specific specific ADJ dr26xw45v34 2 5 lineage lineage NOUN dr26xw45v34 2 6 trees tree NOUN dr26xw45v34 2 7 towards towards ADP dr26xw45v34 2 8 mature mature ADJ dr26xw45v34 2 9 blood blood NOUN dr26xw45v34 2 10 cells cell NOUN dr26xw45v34 2 11 responsible responsible ADJ dr26xw45v34 2 12 for for ADP dr26xw45v34 2 13 systemic systemic ADJ dr26xw45v34 2 14 oxygen oxygen NOUN dr26xw45v34 2 15 transport transport NOUN dr26xw45v34 2 16 ( ( PUNCT dr26xw45v34 2 17 erythrocytes erythrocyte NOUN dr26xw45v34 2 18 ) ) PUNCT dr26xw45v34 2 19 and and CCONJ dr26xw45v34 2 20 immune immune ADJ dr26xw45v34 2 21 cells cell NOUN dr26xw45v34 2 22 responsible responsible ADJ dr26xw45v34 2 23 for for ADP dr26xw45v34 2 24 host host NOUN dr26xw45v34 2 25 defense defense NOUN dr26xw45v34 2 26 . . PUNCT dr26xw45v34 3 1 this this DET dr26xw45v34 3 2 differentiation differentiation NOUN dr26xw45v34 3 3 process process NOUN dr26xw45v34 3 4 is be AUX dr26xw45v34 3 5 coordinated coordinate VERB dr26xw45v34 3 6 by by ADP dr26xw45v34 3 7 a a DET dr26xw45v34 3 8 host host NOUN dr26xw45v34 3 9 of of ADP dr26xw45v34 3 10 factors factor NOUN dr26xw45v34 3 11 including include VERB dr26xw45v34 3 12 transcription transcription NOUN dr26xw45v34 3 13 factors factor NOUN dr26xw45v34 3 14 and and CCONJ dr26xw45v34 3 15 cytokines cytokine NOUN dr26xw45v34 3 16 . . PUNCT dr26xw45v34 4 1 recently recently ADV dr26xw45v34 4 2 the the DET dr26xw45v34 4 3 role role NOUN dr26xw45v34 4 4 of of ADP dr26xw45v34 4 5 micrornas microrna NOUN dr26xw45v34 4 6 ( ( PUNCT dr26xw45v34 4 7 mirnas mirnas PROPN dr26xw45v34 4 8 ) ) PUNCT dr26xw45v34 4 9 in in ADP dr26xw45v34 4 10 this this DET dr26xw45v34 4 11 process process NOUN dr26xw45v34 4 12 has have AUX dr26xw45v34 4 13 garnered garner VERB dr26xw45v34 4 14 more more ADJ dr26xw45v34 4 15 appreciation appreciation NOUN dr26xw45v34 4 16 . . PUNCT dr26xw45v34 5 1 mirnas mirna NOUN dr26xw45v34 5 2 are be AUX dr26xw45v34 5 3 small small ADJ dr26xw45v34 5 4 , , PUNCT dr26xw45v34 5 5 noncoding noncode VERB dr26xw45v34 5 6 rnas rna NOUN dr26xw45v34 5 7 that that PRON dr26xw45v34 5 8 have have VERB dr26xw45v34 5 9 direct direct ADJ dr26xw45v34 5 10 regulatory regulatory ADJ dr26xw45v34 5 11 capacity capacity NOUN dr26xw45v34 5 12 over over ADP dr26xw45v34 5 13 both both CCONJ dr26xw45v34 5 14 the the DET dr26xw45v34 5 15 lineage lineage NOUN dr26xw45v34 5 16 commitment commitment NOUN dr26xw45v34 5 17 process process NOUN dr26xw45v34 5 18 as as ADV dr26xw45v34 5 19 well well ADV dr26xw45v34 5 20 as as ADP dr26xw45v34 5 21 immune immune ADJ dr26xw45v34 5 22 cell cell NOUN dr26xw45v34 5 23 functions function NOUN dr26xw45v34 5 24 upon upon SCONJ dr26xw45v34 5 25 terminal terminal ADJ dr26xw45v34 5 26 differentiation differentiation NOUN dr26xw45v34 5 27 . . PUNCT dr26xw45v34 6 1 the the DET dr26xw45v34 6 2 aim aim NOUN dr26xw45v34 6 3 of of ADP dr26xw45v34 6 4 this this DET dr26xw45v34 6 5 dissertation dissertation NOUN dr26xw45v34 6 6 was be AUX dr26xw45v34 6 7 to to PART dr26xw45v34 6 8 illuminate illuminate VERB dr26xw45v34 6 9 the the DET dr26xw45v34 6 10 role role NOUN dr26xw45v34 6 11 of of ADP dr26xw45v34 6 12 mirna mirna PROPN dr26xw45v34 6 13 cluster cluster PROPN dr26xw45v34 6 14 mirn23a mirn23a ADJ dr26xw45v34 6 15 in in ADP dr26xw45v34 6 16 macrophage macrophage NOUN dr26xw45v34 6 17 function function NOUN dr26xw45v34 6 18 as as ADV dr26xw45v34 6 19 well well ADV dr26xw45v34 6 20 as as ADP dr26xw45v34 6 21 in in ADP dr26xw45v34 6 22 acute acute ADJ dr26xw45v34 6 23 myeloid myeloid PROPN dr26xw45v34 6 24 leukemia leukemia NOUN dr26xw45v34 6 25 ( ( PUNCT dr26xw45v34 6 26 aml aml PROPN dr26xw45v34 6 27 ) ) PUNCT dr26xw45v34 6 28 . . PUNCT dr26xw45v34 7 1 in in ADP dr26xw45v34 7 2 chapter chapter NOUN dr26xw45v34 7 3 2 2 NUM dr26xw45v34 7 4 , , PUNCT dr26xw45v34 7 5 i i PRON dr26xw45v34 7 6 isolate isolate VERB dr26xw45v34 7 7 primary primary ADJ dr26xw45v34 7 8 bone bone NOUN dr26xw45v34 7 9 marrow marrow NOUN dr26xw45v34 7 10 derived derive VERB dr26xw45v34 7 11 macrophages macrophage NOUN dr26xw45v34 7 12 ( ( PUNCT dr26xw45v34 7 13 bmdms bmdms PROPN dr26xw45v34 7 14 ) ) PUNCT dr26xw45v34 7 15 from from ADP dr26xw45v34 7 16 mirn23a mirn23a ADJ dr26xw45v34 7 17 germline germline NOUN dr26xw45v34 7 18 knockout knockout NOUN dr26xw45v34 7 19 mice mouse NOUN dr26xw45v34 7 20 and and CCONJ dr26xw45v34 7 21 observe observe VERB dr26xw45v34 7 22 that that DET dr26xw45v34 7 23 loss loss NOUN dr26xw45v34 7 24 of of ADP dr26xw45v34 7 25 mirn23a mirn23a ADJ dr26xw45v34 7 26 results result NOUN dr26xw45v34 7 27 in in ADP dr26xw45v34 7 28 a a DET dr26xw45v34 7 29 more more ADV dr26xw45v34 7 30 anti anti ADJ dr26xw45v34 7 31 - - ADJ dr26xw45v34 7 32 inflammatory inflammatory ADJ dr26xw45v34 7 33 macrophage macrophage NOUN dr26xw45v34 7 34 . . PUNCT dr26xw45v34 8 1 i i PRON dr26xw45v34 8 2 then then ADV dr26xw45v34 8 3 investigate investigate VERB dr26xw45v34 8 4 the the DET dr26xw45v34 8 5 physiological physiological ADJ dr26xw45v34 8 6 impact impact NOUN dr26xw45v34 8 7 of of ADP dr26xw45v34 8 8 losing lose VERB dr26xw45v34 8 9 mirn23a mirn23a ADJ dr26xw45v34 8 10 expression expression NOUN dr26xw45v34 8 11 in in ADP dr26xw45v34 8 12 the the DET dr26xw45v34 8 13 tumor tumor NOUN dr26xw45v34 8 14 microenvironment microenvironment NOUN dr26xw45v34 8 15 . . PUNCT dr26xw45v34 9 1 chapter chapter NOUN dr26xw45v34 9 2 3 3 NUM dr26xw45v34 9 3 focuses focus VERB dr26xw45v34 9 4 on on ADP dr26xw45v34 9 5 the the DET dr26xw45v34 9 6 physiological physiological ADJ dr26xw45v34 9 7 consequences consequence NOUN dr26xw45v34 9 8 of of ADP dr26xw45v34 9 9 mirn23a mirn23a ADJ dr26xw45v34 9 10 and and CCONJ dr26xw45v34 9 11 mirn23b mirn23b ADJ dr26xw45v34 9 12 loss loss NOUN dr26xw45v34 9 13 ( ( PUNCT dr26xw45v34 9 14 mirn23a-/and mirn23a-/and NOUN dr26xw45v34 9 15 mirn23a-/-mirn23b-/- mirn23a-/-mirn23b-/- PRON dr26xw45v34 9 16 ) ) PUNCT dr26xw45v34 9 17 in in ADP dr26xw45v34 9 18 hematopoietic hematopoietic ADJ dr26xw45v34 9 19 stem stem NOUN dr26xw45v34 9 20 cell cell NOUN dr26xw45v34 9 21 ( ( PUNCT dr26xw45v34 9 22 hsc hsc NOUN dr26xw45v34 9 23 ) ) PUNCT dr26xw45v34 9 24 health health NOUN dr26xw45v34 9 25 and and CCONJ dr26xw45v34 9 26 disease disease NOUN dr26xw45v34 9 27 . . PUNCT dr26xw45v34 10 1 this this DET dr26xw45v34 10 2 chapter chapter NOUN dr26xw45v34 10 3 shows show VERB dr26xw45v34 10 4 that that SCONJ dr26xw45v34 10 5 mirn23a mirn23a ADJ dr26xw45v34 10 6 and and CCONJ dr26xw45v34 10 7 mirn23b mirn23b ADJ dr26xw45v34 10 8 expression expression NOUN dr26xw45v34 10 9 is be AUX dr26xw45v34 10 10 important important ADJ dr26xw45v34 10 11 to to PART dr26xw45v34 10 12 hsc hsc VERB dr26xw45v34 10 13 fitness fitness NOUN dr26xw45v34 10 14 has have VERB dr26xw45v34 10 15 a a DET dr26xw45v34 10 16 strikingly strikingly ADV dr26xw45v34 10 17 opposite opposite ADJ dr26xw45v34 10 18 influence influence NOUN dr26xw45v34 10 19 under under ADP dr26xw45v34 10 20 leukemic leukemic ADJ dr26xw45v34 10 21 context context NOUN dr26xw45v34 10 22 by by ADP dr26xw45v34 10 23 investigating investigate VERB dr26xw45v34 10 24 if if SCONJ dr26xw45v34 10 25 mirn23a mirn23a ADJ dr26xw45v34 10 26 acts act VERB dr26xw45v34 10 27 as as ADP dr26xw45v34 10 28 a a DET dr26xw45v34 10 29 tumor tumor NOUN dr26xw45v34 10 30 suppressor suppressor NOUN dr26xw45v34 10 31 or or CCONJ dr26xw45v34 10 32 oncogene oncogene NOUN dr26xw45v34 10 33 in in ADP dr26xw45v34 10 34 aml aml PROPN dr26xw45v34 10 35 driven drive VERB dr26xw45v34 10 36 by by ADP dr26xw45v34 10 37 the the DET dr26xw45v34 10 38 fusion fusion NOUN dr26xw45v34 10 39 protein protein NOUN dr26xw45v34 10 40 aml1eto aml1eto PROPN dr26xw45v34 10 41 . . PUNCT dr26xw45v34 11 1 together together ADV dr26xw45v34 11 2 , , PUNCT dr26xw45v34 11 3 this this DET dr26xw45v34 11 4 work work NOUN dr26xw45v34 11 5 augments augment VERB dr26xw45v34 11 6 our our PRON dr26xw45v34 11 7 understanding understanding NOUN dr26xw45v34 11 8 of of ADP dr26xw45v34 11 9 how how SCONJ dr26xw45v34 11 10 mirna mirna PROPN dr26xw45v34 11 11 dysregulation dysregulation NOUN dr26xw45v34 11 12 leads lead VERB dr26xw45v34 11 13 to to ADP dr26xw45v34 11 14 disease disease NOUN dr26xw45v34 11 15 and and CCONJ dr26xw45v34 11 16 how how SCONJ dr26xw45v34 11 17 to to PART dr26xw45v34 11 18 better well ADV dr26xw45v34 11 19 treat treat VERB dr26xw45v34 11 20 these these DET dr26xw45v34 11 21 conditions condition NOUN dr26xw45v34 11 22 . . PUNCT