id sid tid token lemma pos f7623b61c1w 1 1 despite despite SCONJ f7623b61c1w 1 2 several several ADJ f7623b61c1w 1 3 discoveries discovery NOUN f7623b61c1w 1 4 furthering further VERB f7623b61c1w 1 5 our our PRON f7623b61c1w 1 6 understanding understanding NOUN f7623b61c1w 1 7 of of ADP f7623b61c1w 1 8 nephrogenesis nephrogenesis NOUN f7623b61c1w 1 9 , , PUNCT f7623b61c1w 1 10 the the DET f7623b61c1w 1 11 factors factor NOUN f7623b61c1w 1 12 that that PRON f7623b61c1w 1 13 influence influence VERB f7623b61c1w 1 14 cell cell NOUN f7623b61c1w 1 15 fate fate NOUN f7623b61c1w 1 16 decisions decision NOUN f7623b61c1w 1 17 within within ADP f7623b61c1w 1 18 the the DET f7623b61c1w 1 19 nephron nephron NOUN f7623b61c1w 1 20 remain remain VERB f7623b61c1w 1 21 largely largely ADV f7623b61c1w 1 22 unknown unknown ADJ f7623b61c1w 1 23 . . PUNCT f7623b61c1w 2 1 the the DET f7623b61c1w 2 2 zebrafish zebrafish NOUN f7623b61c1w 2 3 , , PUNCT f7623b61c1w 2 4 danio danio PROPN f7623b61c1w 2 5 rerio rerio PROPN f7623b61c1w 2 6 , , PUNCT f7623b61c1w 2 7 forms form VERB f7623b61c1w 2 8 a a DET f7623b61c1w 2 9 simple simple ADJ f7623b61c1w 2 10 embryonic embryonic ADJ f7623b61c1w 2 11 kidney kidney NOUN f7623b61c1w 2 12 organized organize VERB f7623b61c1w 2 13 in in ADP f7623b61c1w 2 14 a a DET f7623b61c1w 2 15 proximal proximal ADJ f7623b61c1w 2 16 - - PUNCT f7623b61c1w 2 17 distal distal ADJ f7623b61c1w 2 18 pattern pattern NOUN f7623b61c1w 2 19 of of ADP f7623b61c1w 2 20 contiguous contiguous ADJ f7623b61c1w 2 21 segments segment NOUN f7623b61c1w 2 22 homologous homologous ADJ f7623b61c1w 2 23 to to ADP f7623b61c1w 2 24 the the DET f7623b61c1w 2 25 human human PROPN f7623b61c1w 2 26 nephron nephron PROPN f7623b61c1w 2 27 . . PUNCT f7623b61c1w 3 1 here here ADV f7623b61c1w 3 2 , , PUNCT f7623b61c1w 3 3 we we PRON f7623b61c1w 3 4 performed perform VERB f7623b61c1w 3 5 a a DET f7623b61c1w 3 6 multiplex multiplex ADJ f7623b61c1w 3 7 chemical chemical ADJ f7623b61c1w 3 8 genetic genetic ADJ f7623b61c1w 3 9 screen screen NOUN f7623b61c1w 3 10 using use VERB f7623b61c1w 3 11 zebrafish zebrafish NOUN f7623b61c1w 3 12 embryos embryo NOUN f7623b61c1w 3 13 to to PART f7623b61c1w 3 14 determine determine VERB f7623b61c1w 3 15 factors factor NOUN f7623b61c1w 3 16 that that PRON f7623b61c1w 3 17 regulate regulate VERB f7623b61c1w 3 18 proximal proximal ADJ f7623b61c1w 3 19 and and CCONJ f7623b61c1w 3 20 distal distal ADJ f7623b61c1w 3 21 nephron nephron PROPN f7623b61c1w 3 22 fate fate NOUN f7623b61c1w 3 23 choices choice NOUN f7623b61c1w 3 24 . . PUNCT f7623b61c1w 4 1 employing employ VERB f7623b61c1w 4 2 this this DET f7623b61c1w 4 3 method method NOUN f7623b61c1w 4 4 , , PUNCT f7623b61c1w 4 5 we we PRON f7623b61c1w 4 6 identified identify VERB f7623b61c1w 4 7 prostaglandins prostaglandin NOUN f7623b61c1w 4 8 as as ADP f7623b61c1w 4 9 a a DET f7623b61c1w 4 10 major major ADJ f7623b61c1w 4 11 player player NOUN f7623b61c1w 4 12 in in ADP f7623b61c1w 4 13 nephrogenesis nephrogenesis NOUN f7623b61c1w 4 14 , , PUNCT f7623b61c1w 4 15 which which PRON f7623b61c1w 4 16 have have AUX f7623b61c1w 4 17 been be AUX f7623b61c1w 4 18 previously previously ADV f7623b61c1w 4 19 shown show VERB f7623b61c1w 4 20 to to PART f7623b61c1w 4 21 dictate dictate VERB f7623b61c1w 4 22 liver liver NOUN f7623b61c1w 4 23 versus versus ADP f7623b61c1w 4 24 pancreas pancreas ADJ f7623b61c1w 4 25 cell cell NOUN f7623b61c1w 4 26 fate fate NOUN f7623b61c1w 4 27 decisions decision NOUN f7623b61c1w 4 28 . . PUNCT f7623b61c1w 5 1 we we PRON f7623b61c1w 5 2 found find VERB f7623b61c1w 5 3 that that SCONJ f7623b61c1w 5 4 prostaglandin prostaglandin NOUN f7623b61c1w 5 5 agonists agonist NOUN f7623b61c1w 5 6 restricted restrict VERB f7623b61c1w 5 7 distal distal ADJ f7623b61c1w 5 8 segment segment NOUN f7623b61c1w 5 9 formation formation NOUN f7623b61c1w 5 10 and and CCONJ f7623b61c1w 5 11 expanded expand VERB f7623b61c1w 5 12 the the DET f7623b61c1w 5 13 proximal proximal ADJ f7623b61c1w 5 14 segment segment NOUN f7623b61c1w 5 15 lineage lineage NOUN f7623b61c1w 5 16 during during ADP f7623b61c1w 5 17 nephrogenesis nephrogenesis NOUN f7623b61c1w 5 18 . . PUNCT f7623b61c1w 6 1 genetic genetic ADJ f7623b61c1w 6 2 abrogation abrogation NOUN f7623b61c1w 6 3 or or CCONJ f7623b61c1w 6 4 inhibition inhibition NOUN f7623b61c1w 6 5 of of ADP f7623b61c1w 6 6 the the DET f7623b61c1w 6 7 prostaglandin prostaglandin NOUN f7623b61c1w 6 8 producing produce VERB f7623b61c1w 6 9 enzymes enzyme NOUN f7623b61c1w 6 10 , , PUNCT f7623b61c1w 6 11 prostaglandin prostaglandin NOUN f7623b61c1w 6 12 - - PUNCT f7623b61c1w 6 13 endoperoxide endoperoxide ADJ f7623b61c1w 6 14 synthase synthase NOUN f7623b61c1w 6 15 1 1 NUM f7623b61c1w 6 16 or or CCONJ f7623b61c1w 6 17 2a 2a NUM f7623b61c1w 6 18 ( ( PUNCT f7623b61c1w 6 19 also also ADV f7623b61c1w 6 20 known know VERB f7623b61c1w 6 21 as as ADP f7623b61c1w 6 22 cox-1 cox-1 PRON f7623b61c1w 6 23 / / SYM f7623b61c1w 6 24 ptgs1 ptgs1 PROPN f7623b61c1w 6 25 and and CCONJ f7623b61c1w 6 26 cox-2 cox-2 NOUN f7623b61c1w 6 27 / / SYM f7623b61c1w 6 28 ptgs2a ptgs2a NOUN f7623b61c1w 6 29 respectively respectively ADV f7623b61c1w 6 30 ) ) PUNCT f7623b61c1w 6 31 , , PUNCT f7623b61c1w 6 32 or or CCONJ f7623b61c1w 6 33 the the DET f7623b61c1w 6 34 prostaglandin prostaglandin NOUN f7623b61c1w 6 35 e e NOUN f7623b61c1w 6 36 receptor receptor NOUN f7623b61c1w 6 37 2a 2a NUM f7623b61c1w 6 38 or or CCONJ f7623b61c1w 6 39 4a 4a PROPN f7623b61c1w 6 40 ( ( PUNCT f7623b61c1w 6 41 ptger2a ptger2a PROPN f7623b61c1w 6 42 , , PUNCT f7623b61c1w 6 43 ptger4a ptger4a SPACE f7623b61c1w 6 44 ) ) PUNCT f7623b61c1w 6 45 , , PUNCT f7623b61c1w 6 46 which which PRON f7623b61c1w 6 47 we we PRON f7623b61c1w 6 48 found find VERB f7623b61c1w 6 49 to to PART f7623b61c1w 6 50 be be AUX f7623b61c1w 6 51 expressed express VERB f7623b61c1w 6 52 in in ADP f7623b61c1w 6 53 renal renal ADJ f7623b61c1w 6 54 progenitors progenitor NOUN f7623b61c1w 6 55 , , PUNCT f7623b61c1w 6 56 triggered trigger VERB f7623b61c1w 6 57 an an DET f7623b61c1w 6 58 alteration alteration NOUN f7623b61c1w 6 59 in in ADP f7623b61c1w 6 60 the the DET f7623b61c1w 6 61 balance balance NOUN f7623b61c1w 6 62 of of ADP f7623b61c1w 6 63 distal distal ADJ f7623b61c1w 6 64 segment segment NOUN f7623b61c1w 6 65 fates fate NOUN f7623b61c1w 6 66 . . PUNCT f7623b61c1w 7 1 of of ADP f7623b61c1w 7 2 particular particular ADJ f7623b61c1w 7 3 note note NOUN f7623b61c1w 7 4 , , PUNCT f7623b61c1w 7 5 distal distal ADJ f7623b61c1w 7 6 segment segment NOUN f7623b61c1w 7 7 fate fate NOUN f7623b61c1w 7 8 in in ADP f7623b61c1w 7 9 ptgs1 ptgs1 NOUN f7623b61c1w 7 10 or or CCONJ f7623b61c1w 7 11 ptgs2a ptgs2a NOUN f7623b61c1w 7 12 deficient deficient ADJ f7623b61c1w 7 13 embryos embryo NOUN f7623b61c1w 7 14 was be AUX f7623b61c1w 7 15 rescued rescue VERB f7623b61c1w 7 16 by by ADP f7623b61c1w 7 17 exogenous exogenous ADJ f7623b61c1w 7 18 prostaglandin prostaglandin NOUN f7623b61c1w 7 19 treatment treatment NOUN f7623b61c1w 7 20 . . PUNCT f7623b61c1w 8 1 further far ADV f7623b61c1w 8 2 , , PUNCT f7623b61c1w 8 3 we we PRON f7623b61c1w 8 4 saw see VERB f7623b61c1w 8 5 that that DET f7623b61c1w 8 6 overexpression overexpression NOUN f7623b61c1w 8 7 or or CCONJ f7623b61c1w 8 8 inhibition inhibition NOUN f7623b61c1w 8 9 of of ADP f7623b61c1w 8 10 the the DET f7623b61c1w 8 11 prostaglandin prostaglandin NOUN f7623b61c1w 8 12 pathway pathway NOUN f7623b61c1w 8 13 significantly significantly ADV f7623b61c1w 8 14 altered alter VERB f7623b61c1w 8 15 the the DET f7623b61c1w 8 16 renal renal ADJ f7623b61c1w 8 17 progenitor progenitor NOUN f7623b61c1w 8 18 expression expression NOUN f7623b61c1w 8 19 domains domain NOUN f7623b61c1w 8 20 , , PUNCT f7623b61c1w 8 21 sim1a sim1a PROPN f7623b61c1w 8 22 , , PUNCT f7623b61c1w 8 23 irx3b irx3b SPACE f7623b61c1w 8 24 , , PUNCT f7623b61c1w 8 25 and and CCONJ f7623b61c1w 8 26 mecom mecom PROPN f7623b61c1w 8 27 , , PUNCT f7623b61c1w 8 28 which which PRON f7623b61c1w 8 29 are be AUX f7623b61c1w 8 30 necessary necessary ADJ f7623b61c1w 8 31 for for ADP f7623b61c1w 8 32 proximal proximal ADJ f7623b61c1w 8 33 and and CCONJ f7623b61c1w 8 34 distal distal ADJ f7623b61c1w 8 35 tubule tubule NOUN f7623b61c1w 8 36 patterning patterning NOUN f7623b61c1w 8 37 . . PUNCT f7623b61c1w 9 1 epistasis epistasis NOUN f7623b61c1w 9 2 studies study NOUN f7623b61c1w 9 3 suggest suggest VERB f7623b61c1w 9 4 that that SCONJ f7623b61c1w 9 5 prostaglandin prostaglandin NOUN f7623b61c1w 9 6 signaling signal VERB f7623b61c1w 9 7 functions function NOUN f7623b61c1w 9 8 upstream upstream ADV f7623b61c1w 9 9 of of ADP f7623b61c1w 9 10 these these DET f7623b61c1w 9 11 transcription transcription NOUN f7623b61c1w 9 12 factors factor NOUN f7623b61c1w 9 13 . . PUNCT f7623b61c1w 10 1 taken take VERB f7623b61c1w 10 2 together together ADV f7623b61c1w 10 3 , , PUNCT f7623b61c1w 10 4 these these DET f7623b61c1w 10 5 findings finding NOUN f7623b61c1w 10 6 show show VERB f7623b61c1w 10 7 for for ADP f7623b61c1w 10 8 the the DET f7623b61c1w 10 9 first first ADJ f7623b61c1w 10 10 time time NOUN f7623b61c1w 10 11 that that SCONJ f7623b61c1w 10 12 prostaglandin prostaglandin NOUN f7623b61c1w 10 13 signaling signal VERB f7623b61c1w 10 14 is be AUX f7623b61c1w 10 15 an an DET f7623b61c1w 10 16 essential essential ADJ f7623b61c1w 10 17 component component NOUN f7623b61c1w 10 18 of of ADP f7623b61c1w 10 19 nephron nephron PROPN f7623b61c1w 10 20 cell cell NOUN f7623b61c1w 10 21 fate fate NOUN f7623b61c1w 10 22 choice choice NOUN f7623b61c1w 10 23 , , PUNCT f7623b61c1w 10 24 and and CCONJ f7623b61c1w 10 25 indicate indicate VERB f7623b61c1w 10 26 that that SCONJ f7623b61c1w 10 27 the the DET f7623b61c1w 10 28 prostaglandin prostaglandin NOUN f7623b61c1w 10 29 family family NOUN f7623b61c1w 10 30 may may AUX f7623b61c1w 10 31 have have VERB f7623b61c1w 10 32 considerable considerable ADJ f7623b61c1w 10 33 implications implication NOUN f7623b61c1w 10 34 in in ADP f7623b61c1w 10 35 understanding understand VERB f7623b61c1w 10 36 how how SCONJ f7623b61c1w 10 37 to to PART f7623b61c1w 10 38 treat treat VERB f7623b61c1w 10 39 kidney kidney NOUN f7623b61c1w 10 40 failure failure NOUN f7623b61c1w 10 41 that that PRON f7623b61c1w 10 42 arise arise VERB f7623b61c1w 10 43 from from ADP f7623b61c1w 10 44 congenital congenital ADJ f7623b61c1w 10 45 kidney kidney NOUN f7623b61c1w 10 46 diseases disease NOUN f7623b61c1w 10 47 and and CCONJ f7623b61c1w 10 48 end end ADJ f7623b61c1w 10 49 - - PUNCT f7623b61c1w 10 50 stage stage NOUN f7623b61c1w 10 51 renal renal ADJ f7623b61c1w 10 52 disease disease NOUN f7623b61c1w 10 53 . . PUNCT