id	sid	tid	token	lemma	pos
ff365427x30	1	1	the	the	DET
ff365427x30	1	2	introduction	introduction	NOUN
ff365427x30	1	3	of	of	ADP
ff365427x30	1	4	β	β	PROPN
ff365427x30	1	5	-	-	PUNCT
ff365427x30	1	6	lactam	lactam	NOUN
ff365427x30	1	7	antibiotics	antibiotic	NOUN
ff365427x30	1	8	to	to	ADP
ff365427x30	1	9	our	our	PRON
ff365427x30	1	10	healthcare	healthcare	NOUN
ff365427x30	1	11	repertoire	repertoire	NOUN
ff365427x30	1	12	is	be	AUX
ff365427x30	1	13	one	one	NUM
ff365427x30	1	14	of	of	ADP
ff365427x30	1	15	the	the	DET
ff365427x30	1	16	greatest	great	ADJ
ff365427x30	1	17	innovations	innovation	NOUN
ff365427x30	1	18	of	of	ADP
ff365427x30	1	19	the	the	DET
ff365427x30	1	20	20th	20th	ADJ
ff365427x30	1	21	century	century	NOUN
ff365427x30	1	22	.	.	PUNCT
ff365427x30	2	1	1	1	NUM
ff365427x30	2	2	these	these	DET
ff365427x30	2	3	molecules	molecule	NOUN
ff365427x30	2	4	are	be	AUX
ff365427x30	2	5	largely	largely	ADV
ff365427x30	2	6	responsible	responsible	ADJ
ff365427x30	2	7	for	for	ADP
ff365427x30	2	8	the	the	DET
ff365427x30	2	9	increase	increase	NOUN
ff365427x30	2	10	in	in	ADP
ff365427x30	2	11	expected	expect	VERB
ff365427x30	2	12	lifespan	lifespan	NOUN
ff365427x30	2	13	as	as	SCONJ
ff365427x30	2	14	they	they	PRON
ff365427x30	2	15	render	render	VERB
ff365427x30	2	16	once	once	SCONJ
ff365427x30	2	17	life	life	NOUN
ff365427x30	2	18	-	-	PUNCT
ff365427x30	2	19	threatening	threaten	VERB
ff365427x30	2	20	bacterial	bacterial	ADJ
ff365427x30	2	21	infections	infection	NOUN
ff365427x30	2	22	easily	easily	ADV
ff365427x30	2	23	curable	curable	ADJ
ff365427x30	2	24	.	.	PUNCT
ff365427x30	3	1	they	they	PRON
ff365427x30	3	2	elicit	elicit	VERB
ff365427x30	3	3	their	their	PRON
ff365427x30	3	4	effect	effect	NOUN
ff365427x30	3	5	through	through	ADP
ff365427x30	3	6	inhibiting	inhibit	VERB
ff365427x30	3	7	penicillin	penicillin	NOUN
ff365427x30	3	8	binding	bind	VERB
ff365427x30	3	9	proteins	protein	NOUN
ff365427x30	3	10	(	(	PUNCT
ff365427x30	3	11	pbps	pbps	X
ff365427x30	3	12	)	)	PUNCT
ff365427x30	3	13	as	as	SCONJ
ff365427x30	3	14	mimics	mimic	NOUN
ff365427x30	3	15	of	of	ADP
ff365427x30	3	16	the	the	DET
ff365427x30	3	17	d	d	PROPN
ff365427x30	3	18	-	-	PUNCT
ff365427x30	3	19	ala	ala	NOUN
ff365427x30	3	20	-	-	PUNCT
ff365427x30	3	21	d	d	NOUN
ff365427x30	3	22	-	-	PUNCT
ff365427x30	3	23	ala	ala	PROPN
ff365427x30	3	24	substrate	substrate	NOUN
ff365427x30	3	25	the	the	DET
ff365427x30	3	26	pbps	pbps	NOUN
ff365427x30	3	27	are	be	AUX
ff365427x30	3	28	responsible	responsible	ADJ
ff365427x30	3	29	for	for	ADP
ff365427x30	3	30	cross	cross	ADJ
ff365427x30	3	31	-	-	ADJ
ff365427x30	3	32	linking	link	VERB
ff365427x30	3	33	in	in	ADP
ff365427x30	3	34	peptidoglycan	peptidoglycan	NOUN
ff365427x30	3	35	synthesis	synthesis	NOUN
ff365427x30	3	36	of	of	ADP
ff365427x30	3	37	the	the	DET
ff365427x30	3	38	bacterial	bacterial	ADJ
ff365427x30	3	39	cell	cell	NOUN
ff365427x30	3	40	wall	wall	NOUN
ff365427x30	3	41	.	.	PUNCT
ff365427x30	4	1	antibiotic	antibiotic	ADJ
ff365427x30	4	2	resistance	resistance	NOUN
ff365427x30	4	3	to	to	ADP
ff365427x30	4	4	β	β	PROPN
ff365427x30	4	5	-	-	PUNCT
ff365427x30	4	6	lactams	lactams	PROPN
ff365427x30	4	7	occurs	occur	VERB
ff365427x30	4	8	via	via	ADP
ff365427x30	4	9	many	many	ADJ
ff365427x30	4	10	different	different	ADJ
ff365427x30	4	11	mechanisms	mechanism	NOUN
ff365427x30	4	12	.	.	PUNCT
ff365427x30	5	1	this	this	DET
ff365427x30	5	2	dissertation	dissertation	NOUN
ff365427x30	5	3	focuses	focus	VERB
ff365427x30	5	4	on	on	ADP
ff365427x30	5	5	β	β	NOUN
ff365427x30	5	6	-	-	PUNCT
ff365427x30	5	7	lactamases	lactamases	PROPN
ff365427x30	5	8	and	and	CCONJ
ff365427x30	5	9	a	a	DET
ff365427x30	5	10	protein	protein	NOUN
ff365427x30	5	11	associated	associate	VERB
ff365427x30	5	12	with	with	ADP
ff365427x30	5	13	signaling	signal	VERB
ff365427x30	5	14	for	for	ADP
ff365427x30	5	15	the	the	DET
ff365427x30	5	16	production	production	NOUN
ff365427x30	5	17	of	of	ADP
ff365427x30	5	18	β	β	NOUN
ff365427x30	5	19	-	-	PUNCT
ff365427x30	5	20	lactamases	lactamase	NOUN
ff365427x30	5	21	by	by	ADP
ff365427x30	5	22	antibiotic	antibiotic	ADJ
ff365427x30	5	23	resistance	resistance	NOUN
ff365427x30	5	24	bacteria	bacteria	NOUN
ff365427x30	5	25	.	.	PUNCT
ff365427x30	6	1	much	much	ADJ
ff365427x30	6	2	of	of	ADP
ff365427x30	6	3	our	our	PRON
ff365427x30	6	4	knowledge	knowledge	NOUN
ff365427x30	6	5	about	about	ADP
ff365427x30	6	6	β	β	PROPN
ff365427x30	6	7	-	-	PUNCT
ff365427x30	6	8	lactamase	lactamase	NOUN
ff365427x30	6	9	resistance	resistance	NOUN
ff365427x30	6	10	proteins	protein	NOUN
ff365427x30	6	11	has	have	AUX
ff365427x30	6	12	come	come	VERB
ff365427x30	6	13	from	from	ADP
ff365427x30	6	14	x	x	NOUN
ff365427x30	6	15	-	-	NOUN
ff365427x30	6	16	ray	ray	NOUN
ff365427x30	6	17	crystallography	crystallography	NOUN
ff365427x30	6	18	studies	study	NOUN
ff365427x30	6	19	.	.	PUNCT
ff365427x30	7	1	2	2	NUM
ff365427x30	7	2	-	-	SYM
ff365427x30	7	3	7	7	NUM
ff365427x30	7	4	two	two	NUM
ff365427x30	7	5	proteins	protein	NOUN
ff365427x30	7	6	in	in	ADP
ff365427x30	7	7	which	which	PRON
ff365427x30	7	8	crystal	crystal	NOUN
ff365427x30	7	9	structures	structure	NOUN
ff365427x30	7	10	are	be	AUX
ff365427x30	7	11	available	available	ADJ
ff365427x30	7	12	are	be	AUX
ff365427x30	7	13	the	the	DET
ff365427x30	7	14	extracellular	extracellular	ADJ
ff365427x30	7	15	sensor	sensor	NOUN
ff365427x30	7	16	domain	domain	NOUN
ff365427x30	7	17	of	of	ADP
ff365427x30	7	18	the	the	DET
ff365427x30	7	19	signaling	signal	VERB
ff365427x30	7	20	protein	protein	NOUN
ff365427x30	7	21	blar1	blar1	NOUN
ff365427x30	7	22	(	(	PUNCT
ff365427x30	7	23	blars	blar	NOUN
ff365427x30	7	24	)	)	PUNCT
ff365427x30	7	25	6from	6from	NUM
ff365427x30	7	26	gram	gram	NOUN
ff365427x30	7	27	-	-	PUNCT
ff365427x30	7	28	positive	positive	ADJ
ff365427x30	7	29	staphylococcus	staphylococcus	PROPN
ff365427x30	7	30	aureus	aureus	PROPN
ff365427x30	7	31	and	and	CCONJ
ff365427x30	7	32	the	the	DET
ff365427x30	7	33	class	class	NOUN
ff365427x30	7	34	d	d	NOUN
ff365427x30	7	35	β	β	NOUN
ff365427x30	7	36	-	-	PUNCT
ff365427x30	7	37	lactamase	lactamase	PROPN
ff365427x30	7	38	oxa-242	oxa-242	PUNCT
ff365427x30	7	39	from	from	ADP
ff365427x30	7	40	the	the	DET
ff365427x30	7	41	gram	gram	ADJ
ff365427x30	7	42	-	-	PUNCT
ff365427x30	7	43	negative	negative	ADJ
ff365427x30	7	44	acinetobacter	acinetobacter	ADJ
ff365427x30	7	45	baumannii	baumannii	NOUN
ff365427x30	7	46	.	.	PUNCT
ff365427x30	8	1	while	while	SCONJ
ff365427x30	8	2	these	these	DET
ff365427x30	8	3	studies	study	NOUN
ff365427x30	8	4	have	have	AUX
ff365427x30	8	5	provided	provide	VERB
ff365427x30	8	6	us	we	PRON
ff365427x30	8	7	with	with	ADP
ff365427x30	8	8	a	a	DET
ff365427x30	8	9	solid	solid	ADJ
ff365427x30	8	10	understanding	understanding	NOUN
ff365427x30	8	11	of	of	ADP
ff365427x30	8	12	how	how	SCONJ
ff365427x30	8	13	these	these	DET
ff365427x30	8	14	proteins	protein	NOUN
ff365427x30	8	15	work	work	VERB
ff365427x30	8	16	,	,	PUNCT
ff365427x30	8	17	these	these	DET
ff365427x30	8	18	structures	structure	NOUN
ff365427x30	8	19	largely	largely	ADV
ff365427x30	8	20	ignore	ignore	VERB
ff365427x30	8	21	information	information	NOUN
ff365427x30	8	22	about	about	ADP
ff365427x30	8	23	the	the	DET
ff365427x30	8	24	mobility	mobility	NOUN
ff365427x30	8	25	and	and	CCONJ
ff365427x30	8	26	dynamics	dynamic	NOUN
ff365427x30	8	27	of	of	ADP
ff365427x30	8	28	the	the	DET
ff365427x30	8	29	protein	protein	NOUN
ff365427x30	8	30	.	.	PUNCT
ff365427x30	9	1	this	this	DET
ff365427x30	9	2	gap	gap	NOUN
ff365427x30	9	3	in	in	ADP
ff365427x30	9	4	knowledge	knowledge	NOUN
ff365427x30	9	5	begs	beg	VERB
ff365427x30	9	6	for	for	ADP
ff365427x30	9	7	further	further	ADJ
ff365427x30	9	8	exploration	exploration	NOUN
ff365427x30	9	9	into	into	ADP
ff365427x30	9	10	characterizing	characterize	VERB
ff365427x30	9	11	the	the	DET
ff365427x30	9	12	dynamics	dynamic	NOUN
ff365427x30	9	13	of	of	ADP
ff365427x30	9	14	regions	region	NOUN
ff365427x30	9	15	implicated	implicate	VERB
ff365427x30	9	16	in	in	ADP
ff365427x30	9	17	both	both	CCONJ
ff365427x30	9	18	binding	bind	VERB
ff365427x30	9	19	and	and	CCONJ
ff365427x30	9	20	hydrolysis	hydrolysis	NOUN
ff365427x30	9	21	of	of	ADP
ff365427x30	9	22	β	β	PROPN
ff365427x30	9	23	-	-	PUNCT
ff365427x30	9	24	lactams	lactams	NOUN
ff365427x30	9	25	.	.	PUNCT
ff365427x30	10	1	nuclear	nuclear	PROPN
ff365427x30	10	2	magnetic	magnetic	PROPN
ff365427x30	10	3	resonance	resonance	NOUN
ff365427x30	10	4	(	(	PUNCT
ff365427x30	10	5	nmr	nmr	NOUN
ff365427x30	10	6	)	)	PUNCT
ff365427x30	10	7	is	be	AUX
ff365427x30	10	8	the	the	DET
ff365427x30	10	9	premier	premier	ADJ
ff365427x30	10	10	method	method	NOUN
ff365427x30	10	11	to	to	PART
ff365427x30	10	12	determine	determine	VERB
ff365427x30	10	13	the	the	DET
ff365427x30	10	14	site	site	NOUN
ff365427x30	10	15	-	-	PUNCT
ff365427x30	10	16	specific	specific	ADJ
ff365427x30	10	17	dynamics	dynamic	NOUN
ff365427x30	10	18	of	of	ADP
ff365427x30	10	19	proteins	protein	NOUN
ff365427x30	10	20	.	.	PUNCT
ff365427x30	11	1	this	this	DET
ff365427x30	11	2	work	work	NOUN
ff365427x30	11	3	focuses	focus	VERB
ff365427x30	11	4	on	on	ADP
ff365427x30	11	5	the	the	DET
ff365427x30	11	6	characterization	characterization	NOUN
ff365427x30	11	7	of	of	ADP
ff365427x30	11	8	the	the	DET
ff365427x30	11	9	backbone	backbone	NOUN
ff365427x30	11	10	dynamics	dynamic	NOUN
ff365427x30	11	11	of	of	ADP
ff365427x30	11	12	blars	blar	NOUN
ff365427x30	11	13	,	,	PUNCT
ff365427x30	11	14	oxa-24/40	oxa-24/40	PROPN
ff365427x30	11	15	,	,	PUNCT
ff365427x30	11	16	and	and	CCONJ
ff365427x30	11	17	oxa-160	oxa-160	NOUN
ff365427x30	11	18	using	use	VERB
ff365427x30	11	19	primarily	primarily	ADV
ff365427x30	11	20	reduced	reduce	VERB
ff365427x30	11	21	spectral	spectral	ADJ
ff365427x30	11	22	density	density	NOUN
ff365427x30	11	23	mapping	mapping	NOUN
ff365427x30	11	24	.	.	PUNCT
ff365427x30	12	1	the	the	DET
ff365427x30	12	2	structure	structure	NOUN
ff365427x30	12	3	equals	equal	VERB
ff365427x30	12	4	function	function	NOUN
ff365427x30	12	5	paradigm	paradigm	NOUN
ff365427x30	12	6	has	have	AUX
ff365427x30	12	7	dominated	dominate	VERB
ff365427x30	12	8	biochemical	biochemical	ADJ
ff365427x30	12	9	thinking	thinking	NOUN
ff365427x30	12	10	since	since	SCONJ
ff365427x30	12	11	the	the	DET
ff365427x30	12	12	advent	advent	NOUN
ff365427x30	12	13	of	of	ADP
ff365427x30	12	14	structural	structural	ADJ
ff365427x30	12	15	biology	biology	NOUN
ff365427x30	12	16	.	.	PUNCT
ff365427x30	13	1	however	however	ADV
ff365427x30	13	2	,	,	PUNCT
ff365427x30	13	3	this	this	DET
ff365427x30	13	4	ideology	ideology	NOUN
ff365427x30	13	5	has	have	AUX
ff365427x30	13	6	largely	largely	ADV
ff365427x30	13	7	assumed	assume	VERB
ff365427x30	13	8	one	one	NUM
ff365427x30	13	9	/	/	SYM
ff365427x30	13	10	the	the	DET
ff365427x30	13	11	structure	structure	NOUN
ff365427x30	13	12	equals	equal	VERB
ff365427x30	13	13	function	function	NOUN
ff365427x30	13	14	.	.	PUNCT
ff365427x30	14	1	this	this	DET
ff365427x30	14	2	thesis	thesis	NOUN
ff365427x30	14	3	highlights	highlight	VERB
ff365427x30	14	4	how	how	SCONJ
ff365427x30	14	5	protein	protein	NOUN
ff365427x30	14	6	dynamics	dynamic	NOUN
ff365427x30	14	7	,	,	PUNCT
ff365427x30	14	8	or	or	CCONJ
ff365427x30	14	9	the	the	DET
ff365427x30	14	10	structural	structural	ADJ
ff365427x30	14	11	ensemble	ensemble	NOUN
ff365427x30	14	12	of	of	ADP
ff365427x30	14	13	a	a	DET
ff365427x30	14	14	protein	protein	NOUN
ff365427x30	14	15	,	,	PUNCT
ff365427x30	14	16	ultimately	ultimately	ADV
ff365427x30	14	17	shapes	shape	VERB
ff365427x30	14	18	a	a	DET
ff365427x30	14	19	proteins	protein	NOUN
ff365427x30	14	20	function	function	NOUN
ff365427x30	14	21	.	.	PUNCT