id	sid	tid	token	lemma	pos
js956d59x83	1	1	gex1a	gex1a	PROPN
js956d59x83	1	2	,	,	PUNCT
js956d59x83	1	3	alternatively	alternatively	ADV
js956d59x83	1	4	known	know	VERB
js956d59x83	1	5	as	as	ADP
js956d59x83	1	6	herboxidiene	herboxidiene	ADJ
js956d59x83	1	7	,	,	PUNCT
js956d59x83	1	8	is	be	AUX
js956d59x83	1	9	a	a	DET
js956d59x83	1	10	polyketide	polyketide	NOUN
js956d59x83	1	11	natural	natural	ADJ
js956d59x83	1	12	product	product	NOUN
js956d59x83	1	13	isolated	isolate	VERB
js956d59x83	1	14	from	from	ADP
js956d59x83	1	15	streptomyces	streptomyce	NOUN
js956d59x83	1	16	chromofuscus	chromofuscus	NOUN
js956d59x83	1	17	that	that	PRON
js956d59x83	1	18	is	be	AUX
js956d59x83	1	19	known	know	VERB
js956d59x83	1	20	to	to	PART
js956d59x83	1	21	target	target	VERB
js956d59x83	1	22	the	the	DET
js956d59x83	1	23	spliceosome	spliceosome	NOUN
js956d59x83	1	24	.	.	PUNCT
js956d59x83	2	1	besides	besides	SCONJ
js956d59x83	2	2	its	its	PRON
js956d59x83	2	3	reported	reported	ADJ
js956d59x83	2	4	anticancer	anticancer	NOUN
js956d59x83	2	5	and	and	CCONJ
js956d59x83	2	6	herbicidal	herbicidal	ADJ
js956d59x83	2	7	activity	activity	NOUN
js956d59x83	2	8	,	,	PUNCT
js956d59x83	2	9	our	our	PRON
js956d59x83	2	10	group	group	NOUN
js956d59x83	2	11	has	have	AUX
js956d59x83	2	12	discovered	discover	VERB
js956d59x83	2	13	that	that	SCONJ
js956d59x83	2	14	gex1a	gex1a	PROPN
js956d59x83	2	15	is	be	AUX
js956d59x83	2	16	able	able	ADJ
js956d59x83	2	17	to	to	PART
js956d59x83	2	18	reverse	reverse	VERB
js956d59x83	2	19	the	the	DET
js956d59x83	2	20	cellular	cellular	ADJ
js956d59x83	2	21	phenotype	phenotype	NOUN
js956d59x83	2	22	associated	associate	VERB
js956d59x83	2	23	with	with	ADP
js956d59x83	2	24	niemann	niemann	PROPN
js956d59x83	2	25	-	-	PUNCT
js956d59x83	2	26	pick	pick	NOUN
js956d59x83	2	27	type	type	NOUN
js956d59x83	2	28	c	c	NOUN
js956d59x83	2	29	,	,	PUNCT
js956d59x83	2	30	or	or	CCONJ
js956d59x83	2	31	npc	npc	PROPN
js956d59x83	2	32	,	,	PUNCT
js956d59x83	2	33	disease	disease	PROPN
js956d59x83	2	34	.	.	PUNCT
js956d59x83	3	1	npc	npc	PROPN
js956d59x83	3	2	is	be	AUX
js956d59x83	3	3	a	a	DET
js956d59x83	3	4	rare	rare	ADJ
js956d59x83	3	5	lysosomal	lysosomal	NOUN
js956d59x83	3	6	storage	storage	NOUN
js956d59x83	3	7	disorder	disorder	NOUN
js956d59x83	3	8	,	,	PUNCT
js956d59x83	3	9	caused	cause	VERB
js956d59x83	3	10	by	by	ADP
js956d59x83	3	11	mutations	mutation	NOUN
js956d59x83	3	12	to	to	ADP
js956d59x83	3	13	the	the	DET
js956d59x83	3	14	npc1	npc1	ADJ
js956d59x83	3	15	or	or	CCONJ
js956d59x83	3	16	npc2	npc2	ADJ
js956d59x83	3	17	genes	gene	NOUN
js956d59x83	3	18	.	.	PUNCT
js956d59x83	4	1	we	we	PRON
js956d59x83	4	2	have	have	AUX
js956d59x83	4	3	shown	show	VERB
js956d59x83	4	4	that	that	SCONJ
js956d59x83	4	5	gex1a	gex1a	PROPN
js956d59x83	4	6	is	be	AUX
js956d59x83	4	7	able	able	ADJ
js956d59x83	4	8	to	to	PART
js956d59x83	4	9	disperse	disperse	VERB
js956d59x83	4	10	the	the	DET
js956d59x83	4	11	characteristic	characteristic	ADJ
js956d59x83	4	12	intracellular	intracellular	ADJ
js956d59x83	4	13	cholesterol	cholesterol	NOUN
js956d59x83	4	14	blockade	blockade	NOUN
js956d59x83	4	15	in	in	ADP
js956d59x83	4	16	npc1	npc1	PROPN
js956d59x83	4	17	mutant	mutant	ADJ
js956d59x83	4	18	cells	cell	NOUN
js956d59x83	4	19	similar	similar	ADJ
js956d59x83	4	20	to	to	ADP
js956d59x83	4	21	other	other	ADJ
js956d59x83	4	22	therapeutic	therapeutic	ADJ
js956d59x83	4	23	agents	agent	NOUN
js956d59x83	4	24	under	under	ADP
js956d59x83	4	25	investigation	investigation	NOUN
js956d59x83	4	26	for	for	ADP
js956d59x83	4	27	this	this	DET
js956d59x83	4	28	disease	disease	NOUN
js956d59x83	4	29	,	,	PUNCT
js956d59x83	4	30	at	at	ADP
js956d59x83	4	31	notably	notably	ADV
js956d59x83	4	32	low	low	ADJ
js956d59x83	4	33	doses	dose	NOUN
js956d59x83	4	34	.	.	PUNCT
js956d59x83	5	1	we	we	PRON
js956d59x83	5	2	developed	develop	VERB
js956d59x83	5	3	a	a	DET
js956d59x83	5	4	platform	platform	NOUN
js956d59x83	5	5	for	for	ADP
js956d59x83	5	6	the	the	DET
js956d59x83	5	7	sustainable	sustainable	ADJ
js956d59x83	5	8	production	production	NOUN
js956d59x83	5	9	of	of	ADP
js956d59x83	5	10	gex1a	gex1a	PROPN
js956d59x83	5	11	from	from	ADP
js956d59x83	5	12	s.	s.	PROPN
js956d59x83	5	13	chromofuscus	chromofuscus	PROPN
js956d59x83	5	14	,	,	PUNCT
js956d59x83	5	15	by	by	ADP
js956d59x83	5	16	optimizing	optimize	VERB
js956d59x83	5	17	the	the	DET
js956d59x83	5	18	media	medium	NOUN
js956d59x83	5	19	composition	composition	NOUN
js956d59x83	5	20	and	and	CCONJ
js956d59x83	5	21	growth	growth	NOUN
js956d59x83	5	22	conditions	condition	NOUN
js956d59x83	5	23	for	for	ADP
js956d59x83	5	24	this	this	DET
js956d59x83	5	25	microorganism	microorganism	NOUN
js956d59x83	5	26	.	.	PUNCT
js956d59x83	6	1	we	we	PRON
js956d59x83	6	2	also	also	ADV
js956d59x83	6	3	determined	determine	VERB
js956d59x83	6	4	that	that	SCONJ
js956d59x83	6	5	fermentation	fermentation	NOUN
js956d59x83	6	6	of	of	ADP
js956d59x83	6	7	s.	s.	PROPN
js956d59x83	6	8	chromofuscus	chromofuscus	PROPN
js956d59x83	6	9	in	in	ADP
js956d59x83	6	10	the	the	DET
js956d59x83	6	11	presence	presence	NOUN
js956d59x83	6	12	of	of	ADP
js956d59x83	6	13	small	small	ADJ
js956d59x83	6	14	molecules	molecule	NOUN
js956d59x83	6	15	that	that	PRON
js956d59x83	6	16	trigger	trigger	VERB
js956d59x83	6	17	the	the	DET
js956d59x83	6	18	native	native	ADJ
js956d59x83	6	19	autoregulatory	autoregulatory	ADJ
js956d59x83	6	20	system	system	NOUN
js956d59x83	6	21	of	of	ADP
js956d59x83	6	22	streptomyces	streptomyce	NOUN
js956d59x83	6	23	has	have	VERB
js956d59x83	6	24	a	a	DET
js956d59x83	6	25	positive	positive	ADJ
js956d59x83	6	26	impact	impact	NOUN
js956d59x83	6	27	on	on	ADP
js956d59x83	6	28	the	the	DET
js956d59x83	6	29	production	production	NOUN
js956d59x83	6	30	of	of	ADP
js956d59x83	6	31	gex1a	gex1a	PROPN
js956d59x83	6	32	.	.	PUNCT
js956d59x83	7	1	we	we	PRON
js956d59x83	7	2	sought	seek	VERB
js956d59x83	7	3	to	to	PART
js956d59x83	7	4	inhibit	inhibit	VERB
js956d59x83	7	5	specific	specific	ADJ
js956d59x83	7	6	stages	stage	NOUN
js956d59x83	7	7	of	of	ADP
js956d59x83	7	8	biosynthesis	biosynthesis	NOUN
js956d59x83	7	9	catalyzed	catalyze	VERB
js956d59x83	7	10	by	by	ADP
js956d59x83	7	11	polyketide	polyketide	NOUN
js956d59x83	7	12	tailoring	tailoring	NOUN
js956d59x83	7	13	enzymes	enzyme	NOUN
js956d59x83	7	14	,	,	PUNCT
js956d59x83	7	15	by	by	ADP
js956d59x83	7	16	incubating	incubate	VERB
js956d59x83	7	17	s.	s.	NOUN
js956d59x83	7	18	chromofuscus	chromofuscus	PROPN
js956d59x83	7	19	with	with	ADP
js956d59x83	7	20	an	an	DET
js956d59x83	7	21	exogenous	exogenous	ADJ
js956d59x83	7	22	inhibitor	inhibitor	NOUN
js956d59x83	7	23	of	of	ADP
js956d59x83	7	24	cytochrome	cytochrome	NOUN
js956d59x83	7	25	p450	p450	PROPN
js956d59x83	7	26	monooxygenases	monooxygenase	NOUN
js956d59x83	7	27	.	.	PUNCT
js956d59x83	8	1	treatment	treatment	NOUN
js956d59x83	8	2	with	with	ADP
js956d59x83	8	3	one	one	NUM
js956d59x83	8	4	specific	specific	ADJ
js956d59x83	8	5	inhibitor	inhibitor	NOUN
js956d59x83	8	6	effectively	effectively	ADV
js956d59x83	8	7	resulted	result	VERB
js956d59x83	8	8	in	in	ADP
js956d59x83	8	9	the	the	DET
js956d59x83	8	10	production	production	NOUN
js956d59x83	8	11	of	of	ADP
js956d59x83	8	12	two	two	NUM
js956d59x83	8	13	putative	putative	ADJ
js956d59x83	8	14	deoxygenated	deoxygenate	VERB
js956d59x83	8	15	gex1a	gex1a	PROPN
js956d59x83	8	16	analogues	analogue	NOUN
js956d59x83	8	17	by	by	ADP
js956d59x83	8	18	s.	s.	PROPN
js956d59x83	8	19	chromofuscus	chromofuscus	PROPN
js956d59x83	8	20	.	.	PUNCT
js956d59x83	9	1	we	we	PRON
js956d59x83	9	2	also	also	ADV
js956d59x83	9	3	attempted	attempt	VERB
js956d59x83	9	4	to	to	PART
js956d59x83	9	5	manipulate	manipulate	VERB
js956d59x83	9	6	gex1a	gex1a	PROPN
js956d59x83	9	7	biosynthesis	biosynthesis	NOUN
js956d59x83	9	8	in	in	ADP
js956d59x83	9	9	s.	s.	PROPN
js956d59x83	9	10	chromofuscus	chromofuscus	PROPN
js956d59x83	9	11	through	through	ADP
js956d59x83	9	12	genetic	genetic	ADJ
js956d59x83	9	13	manipulation	manipulation	NOUN
js956d59x83	9	14	,	,	PUNCT
js956d59x83	9	15	by	by	ADP
js956d59x83	9	16	inactivating	inactivate	VERB
js956d59x83	9	17	one	one	NUM
js956d59x83	9	18	or	or	CCONJ
js956d59x83	9	19	more	more	ADJ
js956d59x83	9	20	of	of	ADP
js956d59x83	9	21	the	the	DET
js956d59x83	9	22	genes	gene	NOUN
js956d59x83	9	23	involved	involve	VERB
js956d59x83	9	24	in	in	ADP
js956d59x83	9	25	tailoring	tailor	VERB
js956d59x83	9	26	the	the	DET
js956d59x83	9	27	gex1a	gex1a	PROPN
js956d59x83	9	28	scaffold.we	scaffold.we	NUM
js956d59x83	9	29	finally	finally	ADV
js956d59x83	9	30	examined	examine	VERB
js956d59x83	9	31	the	the	DET
js956d59x83	9	32	effects	effect	NOUN
js956d59x83	9	33	of	of	ADP
js956d59x83	9	34	gex1a	gex1a	PROPN
js956d59x83	9	35	on	on	ADP
js956d59x83	9	36	in	in	ADP
js956d59x83	9	37	vitro	vitro	X
js956d59x83	9	38	models	model	NOUN
js956d59x83	9	39	of	of	ADP
js956d59x83	9	40	npc	npc	NOUN
js956d59x83	9	41	disease	disease	NOUN
js956d59x83	9	42	at	at	ADP
js956d59x83	9	43	the	the	DET
js956d59x83	9	44	cellular	cellular	ADJ
js956d59x83	9	45	and	and	CCONJ
js956d59x83	9	46	molecular	molecular	ADJ
js956d59x83	9	47	levels	level	NOUN
js956d59x83	9	48	.	.	PUNCT
js956d59x83	10	1	we	we	PRON
js956d59x83	10	2	determined	determine	VERB
js956d59x83	10	3	that	that	SCONJ
js956d59x83	10	4	several	several	ADJ
js956d59x83	10	5	semisynthetic	semisynthetic	ADJ
js956d59x83	10	6	analogues	analogue	NOUN
js956d59x83	10	7	of	of	ADP
js956d59x83	10	8	gex1a	gex1a	PROPN
js956d59x83	10	9	could	could	AUX
js956d59x83	10	10	have	have	VERB
js956d59x83	10	11	a	a	DET
js956d59x83	10	12	comparable	comparable	ADJ
js956d59x83	10	13	impact	impact	NOUN
js956d59x83	10	14	on	on	ADP
js956d59x83	10	15	the	the	DET
js956d59x83	10	16	npc	npc	NOUN
js956d59x83	10	17	phenotype	phenotype	NOUN
js956d59x83	10	18	as	as	ADP
js956d59x83	10	19	the	the	DET
js956d59x83	10	20	natural	natural	ADJ
js956d59x83	10	21	product	product	NOUN
js956d59x83	10	22	and	and	CCONJ
js956d59x83	10	23	highlighted	highlight	VERB
js956d59x83	10	24	the	the	DET
js956d59x83	10	25	effects	effect	NOUN
js956d59x83	10	26	of	of	ADP
js956d59x83	10	27	gex1a	gex1a	PROPN
js956d59x83	10	28	on	on	ADP
js956d59x83	10	29	the	the	DET
js956d59x83	10	30	levels	level	NOUN
js956d59x83	10	31	and	and	CCONJ
js956d59x83	10	32	isoforms	isoform	NOUN
js956d59x83	10	33	of	of	ADP
js956d59x83	10	34	the	the	DET
js956d59x83	10	35	npc1	npc1	PROPN
js956d59x83	10	36	protein	protein	NOUN
js956d59x83	10	37	produced	produce	VERB
js956d59x83	10	38	in	in	ADP
js956d59x83	10	39	response	response	NOUN
js956d59x83	10	40	to	to	ADP
js956d59x83	10	41	treatment	treatment	NOUN
js956d59x83	10	42	.	.	PUNCT
js956d59x83	11	1	lastly	lastly	ADV
js956d59x83	11	2	we	we	PRON
js956d59x83	11	3	performed	perform	VERB
js956d59x83	11	4	rna	rna	NOUN
js956d59x83	11	5	sequencing	sequence	VERB
js956d59x83	11	6	to	to	PART
js956d59x83	11	7	study	study	VERB
js956d59x83	11	8	the	the	DET
js956d59x83	11	9	influence	influence	NOUN
js956d59x83	11	10	of	of	ADP
js956d59x83	11	11	gex1a	gex1a	PROPN
js956d59x83	11	12	on	on	ADP
js956d59x83	11	13	the	the	DET
js956d59x83	11	14	npc	npc	PROPN
js956d59x83	11	15	transcriptome	transcriptome	PROPN
js956d59x83	11	16	.	.	PUNCT
js956d59x83	12	1	a	a	DET
js956d59x83	12	2	complete	complete	ADJ
js956d59x83	12	3	analysis	analysis	NOUN
js956d59x83	12	4	of	of	ADP
js956d59x83	12	5	this	this	DET
js956d59x83	12	6	expression	expression	NOUN
js956d59x83	12	7	data	datum	NOUN
js956d59x83	12	8	,	,	PUNCT
js956d59x83	12	9	which	which	PRON
js956d59x83	12	10	includes	include	VERB
js956d59x83	12	11	isoform	isoform	NOUN
js956d59x83	12	12	-	-	PUNCT
js956d59x83	12	13	specific	specific	ADJ
js956d59x83	12	14	information	information	NOUN
js956d59x83	12	15	relevant	relevant	ADJ
js956d59x83	12	16	to	to	ADP
js956d59x83	12	17	gex1a	gex1a	SPACE
js956d59x83	12	18	's	's	PART
js956d59x83	12	19	role	role	NOUN
js956d59x83	12	20	in	in	ADP
js956d59x83	12	21	splicing	splicing	NOUN
js956d59x83	12	22	modulation	modulation	NOUN
js956d59x83	12	23	,	,	PUNCT
js956d59x83	12	24	is	be	AUX
js956d59x83	12	25	underway	underway	ADJ
js956d59x83	12	26	,	,	PUNCT
js956d59x83	12	27	and	and	CCONJ
js956d59x83	12	28	will	will	AUX
js956d59x83	12	29	be	be	AUX
js956d59x83	12	30	a	a	DET
js956d59x83	12	31	valuable	valuable	ADJ
js956d59x83	12	32	contribution	contribution	NOUN
js956d59x83	12	33	to	to	ADP
js956d59x83	12	34	understanding	understand	VERB
js956d59x83	12	35	how	how	SCONJ
js956d59x83	12	36	this	this	DET
js956d59x83	12	37	natural	natural	ADJ
js956d59x83	12	38	product	product	NOUN
js956d59x83	12	39	,	,	PUNCT
js956d59x83	12	40	and	and	CCONJ
js956d59x83	12	41	potentially	potentially	ADV
js956d59x83	12	42	other	other	ADJ
js956d59x83	12	43	structurally	structurally	ADV
js956d59x83	12	44	related	relate	VERB
js956d59x83	12	45	scaffolds	scaffold	NOUN
js956d59x83	12	46	,	,	PUNCT
js956d59x83	12	47	has	have	VERB
js956d59x83	12	48	a	a	DET
js956d59x83	12	49	beneficial	beneficial	ADJ
js956d59x83	12	50	therapeutic	therapeutic	ADJ
js956d59x83	12	51	effect	effect	NOUN
js956d59x83	12	52	in	in	ADP
js956d59x83	12	53	the	the	DET
js956d59x83	12	54	context	context	NOUN
js956d59x83	12	55	of	of	ADP
js956d59x83	12	56	npc	npc	NOUN
js956d59x83	12	57	disease	disease	NOUN
js956d59x83	12	58	.	.	PUNCT