id	sid	tid	token	lemma	pos
jw827943p88	1	1	pathogenic	pathogenic	ADJ
jw827943p88	1	2	mycobacteria	mycobacterium	NOUN
jw827943p88	1	3	are	be	AUX
jw827943p88	1	4	a	a	DET
jw827943p88	1	5	global	global	ADJ
jw827943p88	1	6	health	health	NOUN
jw827943p88	1	7	burden	burden	NOUN
jw827943p88	1	8	.	.	PUNCT
jw827943p88	2	1	mycobacterium	mycobacterium	NOUN
jw827943p88	2	2	tuberculosis	tuberculosis	NOUN
jw827943p88	2	3	accounts	account	VERB
jw827943p88	2	4	the	the	DET
jw827943p88	2	5	most	most	ADV
jw827943p88	2	6	pathogenic	pathogenic	ADJ
jw827943p88	2	7	mycobacterial	mycobacterial	ADJ
jw827943p88	2	8	infections	infection	NOUN
jw827943p88	2	9	in	in	ADP
jw827943p88	2	10	the	the	DET
jw827943p88	2	11	world	world	NOUN
jw827943p88	2	12	,	,	PUNCT
jw827943p88	2	13	but	but	CCONJ
jw827943p88	2	14	nontuberculous	nontuberculous	ADJ
jw827943p88	2	15	mycobacteria	mycobacteria	PROPN
jw827943p88	2	16	(	(	PUNCT
jw827943p88	2	17	ntm	ntm	X
jw827943p88	2	18	)	)	PUNCT
jw827943p88	2	19	infections	infection	NOUN
jw827943p88	2	20	are	be	AUX
jw827943p88	2	21	on	on	ADP
jw827943p88	2	22	the	the	DET
jw827943p88	2	23	rise	rise	NOUN
jw827943p88	2	24	.	.	PUNCT
jw827943p88	3	1	m.	m.	NOUN
jw827943p88	3	2	tb	tb	PROPN
jw827943p88	3	3	and	and	CCONJ
jw827943p88	3	4	m.	m.	PROPN
jw827943p88	3	5	marinum	marinum	PROPN
jw827943p88	3	6	,	,	PUNCT
jw827943p88	3	7	an	an	DET
jw827943p88	3	8	ntm	ntm	PROPN
jw827943p88	3	9	,	,	PUNCT
jw827943p88	3	10	share	share	NOUN
jw827943p88	3	11	conserved	conserve	VERB
jw827943p88	3	12	mechanisms	mechanism	NOUN
jw827943p88	3	13	of	of	ADP
jw827943p88	3	14	pathogenesis	pathogenesis	NOUN
jw827943p88	3	15	,	,	PUNCT
jw827943p88	3	16	including	include	VERB
jw827943p88	3	17	the	the	DET
jw827943p88	3	18	esx-1	esx-1	X
jw827943p88	3	19	secretion	secretion	NOUN
jw827943p88	3	20	system	system	NOUN
jw827943p88	3	21	.	.	PUNCT
jw827943p88	4	1	we	we	PRON
jw827943p88	4	2	use	use	VERB
jw827943p88	4	3	m.	m.	NOUN
jw827943p88	4	4	marinum	marinum	PROPN
jw827943p88	4	5	as	as	ADP
jw827943p88	4	6	a	a	DET
jw827943p88	4	7	model	model	NOUN
jw827943p88	4	8	for	for	SCONJ
jw827943p88	4	9	m.	m.	NOUN
jw827943p88	4	10	tb	tb	PROPN
jw827943p88	4	11	to	to	PART
jw827943p88	4	12	study	study	VERB
jw827943p88	4	13	esx-1	esx-1	ADP
jw827943p88	4	14	secretion	secretion	NOUN
jw827943p88	4	15	and	and	CCONJ
jw827943p88	4	16	pathogenesis	pathogenesis	NOUN
jw827943p88	4	17	.	.	PUNCT
jw827943p88	5	1	here	here	ADV
jw827943p88	5	2	,	,	PUNCT
jw827943p88	5	3	we	we	PRON
jw827943p88	5	4	use	use	VERB
jw827943p88	5	5	molecular	molecular	ADJ
jw827943p88	5	6	genetics	genetic	NOUN
jw827943p88	5	7	,	,	PUNCT
jw827943p88	5	8	biochemistry	biochemistry	NOUN
jw827943p88	5	9	,	,	PUNCT
jw827943p88	5	10	and	and	CCONJ
jw827943p88	5	11	proteo	proteo	NOUN
jw827943p88	5	12	-	-	PUNCT
jw827943p88	5	13	genetic	genetic	ADJ
jw827943p88	5	14	approaches	approach	NOUN
jw827943p88	5	15	to	to	PART
jw827943p88	5	16	interrogate	interrogate	VERB
jw827943p88	5	17	integral	integral	ADJ
jw827943p88	5	18	aspects	aspect	NOUN
jw827943p88	5	19	of	of	ADP
jw827943p88	5	20	mycobacterial	mycobacterial	ADJ
jw827943p88	5	21	pathobiology	pathobiology	NOUN
jw827943p88	5	22	with	with	ADP
jw827943p88	5	23	specific	specific	ADJ
jw827943p88	5	24	emphasis	emphasis	NOUN
jw827943p88	5	25	on	on	ADP
jw827943p88	5	26	regulation	regulation	NOUN
jw827943p88	5	27	of	of	ADP
jw827943p88	5	28	the	the	DET
jw827943p88	5	29	esx-1	esx-1	X
jw827943p88	5	30	secretion	secretion	NOUN
jw827943p88	5	31	system	system	NOUN
jw827943p88	5	32	.	.	PUNCT
jw827943p88	6	1	using	use	VERB
jw827943p88	6	2	these	these	DET
jw827943p88	6	3	approaches	approach	NOUN
jw827943p88	6	4	,	,	PUNCT
jw827943p88	6	5	we	we	PRON
jw827943p88	6	6	identified	identify	VERB
jw827943p88	6	7	a	a	DET
jw827943p88	6	8	novel	novel	NOUN
jw827943p88	6	9	esx-1	esx-1	X
jw827943p88	6	10	protein	protein	NOUN
jw827943p88	6	11	substrate	substrate	NOUN
jw827943p88	6	12	,	,	PUNCT
jw827943p88	6	13	mmar_2894	mmar_2894	PROPN
jw827943p88	6	14	,	,	PUNCT
jw827943p88	6	15	that	that	PRON
jw827943p88	6	16	is	be	AUX
jw827943p88	6	17	unique	unique	ADJ
jw827943p88	6	18	to	to	PART
jw827943p88	6	19	m.	m.	VERB
jw827943p88	6	20	marinum	marinum	PROPN
jw827943p88	6	21	.	.	PUNCT
jw827943p88	6	22	mmar_2894	mmar_2894	PROPN
jw827943p88	6	23	is	be	AUX
jw827943p88	6	24	important	important	ADJ
jw827943p88	6	25	for	for	ADP
jw827943p88	6	26	esx-1	esx-1	DET
jw827943p88	6	27	secretion	secretion	NOUN
jw827943p88	6	28	in	in	ADP
jw827943p88	6	29	vitro	vitro	X
jw827943p88	6	30	but	but	CCONJ
jw827943p88	6	31	is	be	AUX
jw827943p88	6	32	dispensable	dispensable	ADJ
jw827943p88	6	33	in	in	ADP
jw827943p88	6	34	vivo	vivo	PROPN
jw827943p88	6	35	,	,	PUNCT
jw827943p88	6	36	suggesting	suggest	VERB
jw827943p88	6	37	there	there	PRON
jw827943p88	6	38	may	may	AUX
jw827943p88	6	39	be	be	AUX
jw827943p88	6	40	compensatory	compensatory	ADJ
jw827943p88	6	41	mechanisms	mechanism	NOUN
jw827943p88	6	42	to	to	PART
jw827943p88	6	43	rescue	rescue	VERB
jw827943p88	6	44	loss	loss	NOUN
jw827943p88	6	45	of	of	ADP
jw827943p88	6	46	mmar_2894	mmar_2894	PROPN
jw827943p88	6	47	.	.	PUNCT
jw827943p88	7	1	we	we	PRON
jw827943p88	7	2	also	also	ADV
jw827943p88	7	3	defined	define	VERB
jw827943p88	7	4	roles	role	NOUN
jw827943p88	7	5	of	of	ADP
jw827943p88	7	6	additional	additional	ADJ
jw827943p88	7	7	esx-1	esx-1	X
jw827943p88	7	8	substrates	substrate	NOUN
jw827943p88	7	9	inside	inside	ADP
jw827943p88	7	10	the	the	DET
jw827943p88	7	11	mycobacterial	mycobacterial	ADJ
jw827943p88	7	12	cell	cell	NOUN
jw827943p88	7	13	.	.	PUNCT
jw827943p88	8	1	the	the	DET
jw827943p88	8	2	espe	espe	NOUN
jw827943p88	8	3	and	and	CCONJ
jw827943p88	8	4	espf	espf	PROPN
jw827943p88	8	5	esx-1	esx-1	X
jw827943p88	8	6	substrates	substrate	NOUN
jw827943p88	8	7	are	be	AUX
jw827943p88	8	8	required	require	VERB
jw827943p88	8	9	for	for	ADP
jw827943p88	8	10	the	the	DET
jw827943p88	8	11	lytic	lytic	ADJ
jw827943p88	8	12	activity	activity	NOUN
jw827943p88	8	13	of	of	ADP
jw827943p88	8	14	esx-1	esx-1	ADP
jw827943p88	8	15	outside	outside	ADP
jw827943p88	8	16	the	the	DET
jw827943p88	8	17	cell	cell	NOUN
jw827943p88	8	18	and	and	CCONJ
jw827943p88	8	19	they	they	PRON
jw827943p88	8	20	are	be	AUX
jw827943p88	8	21	negative	negative	ADJ
jw827943p88	8	22	regulators	regulator	NOUN
jw827943p88	8	23	of	of	ADP
jw827943p88	8	24	gene	gene	NOUN
jw827943p88	8	25	expression	expression	NOUN
jw827943p88	8	26	inside	inside	ADP
jw827943p88	8	27	the	the	DET
jw827943p88	8	28	mycobacterial	mycobacterial	ADJ
jw827943p88	8	29	cell	cell	NOUN
jw827943p88	8	30	.	.	PUNCT
jw827943p88	9	1	finally	finally	ADV
jw827943p88	9	2	,	,	PUNCT
jw827943p88	9	3	we	we	PRON
jw827943p88	9	4	identified	identify	VERB
jw827943p88	9	5	a	a	DET
jw827943p88	9	6	novel	novel	ADJ
jw827943p88	9	7	transcriptional	transcriptional	NOUN
jw827943p88	9	8	regulator	regulator	NOUN
jw827943p88	9	9	of	of	ADP
jw827943p88	9	10	the	the	DET
jw827943p88	9	11	esx-1	esx-1	X
jw827943p88	9	12	system	system	NOUN
jw827943p88	9	13	,	,	PUNCT
jw827943p88	9	14	espn	espn	NOUN
jw827943p88	9	15	,	,	PUNCT
jw827943p88	9	16	that	that	PRON
jw827943p88	9	17	is	be	AUX
jw827943p88	9	18	required	require	VERB
jw827943p88	9	19	for	for	ADP
jw827943p88	9	20	pathogenesis	pathogenesis	NOUN
jw827943p88	9	21	and	and	CCONJ
jw827943p88	9	22	whose	whose	DET
jw827943p88	9	23	activity	activity	NOUN
jw827943p88	9	24	is	be	AUX
jw827943p88	9	25	infection	infection	NOUN
jw827943p88	9	26	-	-	PUNCT
jw827943p88	9	27	dependent	dependent	ADJ
jw827943p88	9	28	.	.	PUNCT
jw827943p88	10	1	collectively	collectively	ADV
jw827943p88	10	2	,	,	PUNCT
jw827943p88	10	3	our	our	PRON
jw827943p88	10	4	findings	finding	NOUN
jw827943p88	10	5	have	have	AUX
jw827943p88	10	6	expanded	expand	VERB
jw827943p88	10	7	our	our	PRON
jw827943p88	10	8	understanding	understanding	NOUN
jw827943p88	10	9	of	of	ADP
jw827943p88	10	10	esx-1	esx-1	ADP
jw827943p88	10	11	regulation	regulation	NOUN
jw827943p88	10	12	,	,	PUNCT
jw827943p88	10	13	emphasizing	emphasize	VERB
jw827943p88	10	14	that	that	SCONJ
jw827943p88	10	15	this	this	DET
jw827943p88	10	16	regulation	regulation	NOUN
jw827943p88	10	17	is	be	AUX
jw827943p88	10	18	both	both	CCONJ
jw827943p88	10	19	multifaceted	multifaceted	ADJ
jw827943p88	10	20	and	and	CCONJ
jw827943p88	10	21	complex	complex	ADJ
jw827943p88	10	22	,	,	PUNCT
jw827943p88	10	23	involving	involve	VERB
jw827943p88	10	24	coordination	coordination	NOUN
jw827943p88	10	25	of	of	ADP
jw827943p88	10	26	esx-1	esx-1	ADP
jw827943p88	10	27	substrates	substrate	NOUN
jw827943p88	10	28	and	and	CCONJ
jw827943p88	10	29	transcription	transcription	NOUN
jw827943p88	10	30	factors	factor	NOUN
jw827943p88	10	31	themselves	themselves	PRON
jw827943p88	10	32	.	.	PUNCT