id sid tid token lemma pos k0698625t22 1 1 malaria malaria NOUN k0698625t22 1 2 is be AUX k0698625t22 1 3 a a DET k0698625t22 1 4 severe severe ADJ k0698625t22 1 5 disease disease NOUN k0698625t22 1 6 causing cause VERB k0698625t22 1 7 significant significant ADJ k0698625t22 1 8 morbidity morbidity NOUN k0698625t22 1 9 and and CCONJ k0698625t22 1 10 mortality mortality NOUN k0698625t22 1 11 . . PUNCT k0698625t22 2 1 the the DET k0698625t22 2 2 disease disease NOUN k0698625t22 2 3 is be AUX k0698625t22 2 4 caused cause VERB k0698625t22 2 5 by by ADP k0698625t22 2 6 the the DET k0698625t22 2 7 plasmodium plasmodium NOUN k0698625t22 2 8 species specie NOUN k0698625t22 2 9 of of ADP k0698625t22 2 10 parasites parasite NOUN k0698625t22 2 11 that that PRON k0698625t22 2 12 belong belong VERB k0698625t22 2 13 to to ADP k0698625t22 2 14 the the DET k0698625t22 2 15 phylum phylum NOUN k0698625t22 2 16 apicomplexa apicomplexa PROPN k0698625t22 2 17 . . PUNCT k0698625t22 3 1 transmission transmission NOUN k0698625t22 3 2 of of ADP k0698625t22 3 3 the the DET k0698625t22 3 4 parasite parasite NOUN k0698625t22 3 5 requires require VERB k0698625t22 3 6 the the DET k0698625t22 3 7 completion completion NOUN k0698625t22 3 8 of of ADP k0698625t22 3 9 its its PRON k0698625t22 3 10 life life NOUN k0698625t22 3 11 cycle cycle NOUN k0698625t22 3 12 in in ADP k0698625t22 3 13 the the DET k0698625t22 3 14 mosquito mosquito NOUN k0698625t22 3 15 involving involve VERB k0698625t22 3 16 the the DET k0698625t22 3 17 invasion invasion NOUN k0698625t22 3 18 of of ADP k0698625t22 3 19 salivary salivary ADJ k0698625t22 3 20 glands gland NOUN k0698625t22 3 21 . . PUNCT k0698625t22 4 1 maebl maebl PROPN k0698625t22 4 2 is be AUX k0698625t22 4 3 a a DET k0698625t22 4 4 chimeric chimeric ADJ k0698625t22 4 5 protein protein NOUN k0698625t22 4 6 present present ADJ k0698625t22 4 7 in in ADP k0698625t22 4 8 the the DET k0698625t22 4 9 micronemes microneme NOUN k0698625t22 4 10 of of ADP k0698625t22 4 11 sporozoites sporozoite NOUN k0698625t22 4 12 that that PRON k0698625t22 4 13 invade invade VERB k0698625t22 4 14 salivary salivary ADJ k0698625t22 4 15 glands gland NOUN k0698625t22 4 16 and and CCONJ k0698625t22 4 17 has have AUX k0698625t22 4 18 been be AUX k0698625t22 4 19 shown show VERB k0698625t22 4 20 to to PART k0698625t22 4 21 be be AUX k0698625t22 4 22 essential essential ADJ k0698625t22 4 23 to to ADP k0698625t22 4 24 invasion invasion NOUN k0698625t22 4 25 . . PUNCT k0698625t22 5 1 my my PRON k0698625t22 5 2 hypothesis hypothesis NOUN k0698625t22 5 3 is be AUX k0698625t22 5 4 that that PRON k0698625t22 5 5 successful successful ADJ k0698625t22 5 6 invasion invasion NOUN k0698625t22 5 7 of of ADP k0698625t22 5 8 salivary salivary ADJ k0698625t22 5 9 glands gland NOUN k0698625t22 5 10 requires require VERB k0698625t22 5 11 the the DET k0698625t22 5 12 recognition recognition NOUN k0698625t22 5 13 of of ADP k0698625t22 5 14 a a DET k0698625t22 5 15 specific specific ADJ k0698625t22 5 16 receptor receptor NOUN k0698625t22 5 17 by by ADP k0698625t22 5 18 maebl maebl PROPN k0698625t22 5 19 on on ADP k0698625t22 5 20 salivary salivary ADJ k0698625t22 5 21 glands gland NOUN k0698625t22 5 22 . . PUNCT k0698625t22 6 1 we we PRON k0698625t22 6 2 expect expect VERB k0698625t22 6 3 that that SCONJ k0698625t22 6 4 this this DET k0698625t22 6 5 recognition recognition NOUN k0698625t22 6 6 is be AUX k0698625t22 6 7 dependent dependent ADJ k0698625t22 6 8 on on ADP k0698625t22 6 9 interactions interaction NOUN k0698625t22 6 10 with with ADP k0698625t22 6 11 glycosaminoglycans glycosaminoglycan NOUN k0698625t22 6 12 and and CCONJ k0698625t22 6 13 conformation conformation NOUN k0698625t22 6 14 of of ADP k0698625t22 6 15 the the DET k0698625t22 6 16 ligand ligand NOUN k0698625t22 6 17 domain domain NOUN k0698625t22 6 18 m2 m2 PROPN k0698625t22 6 19 of of ADP k0698625t22 6 20 maebl maebl PROPN k0698625t22 6 21 , , PUNCT k0698625t22 6 22 which which PRON k0698625t22 6 23 is be AUX k0698625t22 6 24 a a DET k0698625t22 6 25 domain domain NOUN k0698625t22 6 26 , , PUNCT k0698625t22 6 27 rich rich ADJ k0698625t22 6 28 in in ADP k0698625t22 6 29 cysteines cysteine NOUN k0698625t22 6 30 and and CCONJ k0698625t22 6 31 other other ADJ k0698625t22 6 32 residues residue NOUN k0698625t22 6 33 typically typically ADV k0698625t22 6 34 important important ADJ k0698625t22 6 35 for for ADP k0698625t22 6 36 3d 3d DET k0698625t22 6 37 structure structure NOUN k0698625t22 6 38 . . PUNCT k0698625t22 7 1 the the DET k0698625t22 7 2 aims aim NOUN k0698625t22 7 3 of of ADP k0698625t22 7 4 my my PRON k0698625t22 7 5 research research NOUN k0698625t22 7 6 are be AUX k0698625t22 7 7 : : PUNCT k0698625t22 7 8 1 1 X k0698625t22 7 9 ) ) PUNCT k0698625t22 7 10 to to PART k0698625t22 7 11 gain gain VERB k0698625t22 7 12 insights insight NOUN k0698625t22 7 13 into into ADP k0698625t22 7 14 the the DET k0698625t22 7 15 structure structure NOUN k0698625t22 7 16 of of ADP k0698625t22 7 17 ligand ligand NOUN k0698625t22 7 18 domain domain NOUN k0698625t22 7 19 m2 m2 NOUN k0698625t22 7 20 and and CCONJ k0698625t22 7 21 to to PART k0698625t22 7 22 determine determine VERB k0698625t22 7 23 its its PRON k0698625t22 7 24 function function NOUN k0698625t22 7 25 of of ADP k0698625t22 7 26 in in ADP k0698625t22 7 27 the the DET k0698625t22 7 28 invasion invasion NOUN k0698625t22 7 29 of of ADP k0698625t22 7 30 mosquito mosquito PROPN k0698625t22 7 31 salivary salivary NOUN k0698625t22 7 32 glands gland NOUN k0698625t22 7 33 , , PUNCT k0698625t22 7 34 2 2 NUM k0698625t22 7 35 ) ) PUNCT k0698625t22 7 36 to to PART k0698625t22 7 37 study study VERB k0698625t22 7 38 the the DET k0698625t22 7 39 role role NOUN k0698625t22 7 40 of of ADP k0698625t22 7 41 glycosaminoglycans glycosaminoglycan NOUN k0698625t22 7 42 in in ADP k0698625t22 7 43 maebl maebl PROPN k0698625t22 7 44 ligand ligand PROPN k0698625t22 7 45 - - PUNCT k0698625t22 7 46 receptor receptor NOUN k0698625t22 7 47 interactions interaction NOUN k0698625t22 7 48 . . PUNCT k0698625t22 8 1 to to PART k0698625t22 8 2 understand understand VERB k0698625t22 8 3 the the DET k0698625t22 8 4 function function NOUN k0698625t22 8 5 of of ADP k0698625t22 8 6 maebl maebl PROPN k0698625t22 8 7 ligand ligand NOUN k0698625t22 8 8 domains domain NOUN k0698625t22 8 9 in in ADP k0698625t22 8 10 the the DET k0698625t22 8 11 invasion invasion NOUN k0698625t22 8 12 of of ADP k0698625t22 8 13 mosquito mosquito PROPN k0698625t22 8 14 salivary salivary NOUN k0698625t22 8 15 glands gland NOUN k0698625t22 8 16 , , PUNCT k0698625t22 8 17 the the DET k0698625t22 8 18 ligand ligand NOUN k0698625t22 8 19 domain domain NOUN k0698625t22 8 20 m2 m2 NOUN k0698625t22 8 21 , , PUNCT k0698625t22 8 22 and and CCONJ k0698625t22 8 23 the the DET k0698625t22 8 24 subdomains subdomain NOUN k0698625t22 8 25 of of ADP k0698625t22 8 26 m2 m2 PROPN k0698625t22 8 27 , , PUNCT k0698625t22 8 28 m2sd1 m2sd1 ADJ k0698625t22 8 29 and and CCONJ k0698625t22 8 30 m2sd2 m2sd2 PROPN k0698625t22 8 31 were be AUX k0698625t22 8 32 cloned clone VERB k0698625t22 8 33 and and CCONJ k0698625t22 8 34 expressed express VERB k0698625t22 8 35 in in ADP k0698625t22 8 36 the the DET k0698625t22 8 37 bl21(de3)plyse bl21(de3)plyse NOUN k0698625t22 8 38 strain strain NOUN k0698625t22 8 39 of of ADP k0698625t22 8 40 e.coli e.coli NOUN k0698625t22 8 41 . . PUNCT k0698625t22 9 1 refolded refolde VERB k0698625t22 9 2 , , PUNCT k0698625t22 9 3 recombinant recombinant ADJ k0698625t22 9 4 proteins protein NOUN k0698625t22 9 5 were be AUX k0698625t22 9 6 analyzed analyze VERB k0698625t22 9 7 by by ADP k0698625t22 9 8 lc lc PROPN k0698625t22 9 9 - - PUNCT k0698625t22 9 10 ms ms PROPN k0698625t22 9 11 / / SYM k0698625t22 9 12 ms ms PROPN k0698625t22 9 13 mass mass PROPN k0698625t22 9 14 spectrometry spectrometry NOUN k0698625t22 9 15 . . PUNCT k0698625t22 10 1 we we PRON k0698625t22 10 2 performed perform VERB k0698625t22 10 3 binding bind VERB k0698625t22 10 4 assays assay NOUN k0698625t22 10 5 using use VERB k0698625t22 10 6 these these DET k0698625t22 10 7 recombinant recombinant ADJ k0698625t22 10 8 proteins protein NOUN k0698625t22 10 9 with with ADP k0698625t22 10 10 anopheles anophele NOUN k0698625t22 10 11 stephensi stephensi PROPN k0698625t22 10 12 salivary salivary NOUN k0698625t22 10 13 glands gland NOUN k0698625t22 10 14 . . PUNCT k0698625t22 11 1 our our PRON k0698625t22 11 2 results result NOUN k0698625t22 11 3 showed show VERB k0698625t22 11 4 that that SCONJ k0698625t22 11 5 refolded refolde VERB k0698625t22 11 6 , , PUNCT k0698625t22 11 7 recombinant recombinant ADJ k0698625t22 11 8 , , PUNCT k0698625t22 11 9 ligand ligand NOUN k0698625t22 11 10 domain domain NOUN k0698625t22 11 11 m2 m2 PROPN k0698625t22 11 12 binds bind VERB k0698625t22 11 13 to to ADP k0698625t22 11 14 mosquito mosquito PROPN k0698625t22 11 15 salivary salivary ADJ k0698625t22 11 16 glands gland NOUN k0698625t22 11 17 , , PUNCT k0698625t22 11 18 while while SCONJ k0698625t22 11 19 reduced reduce VERB k0698625t22 11 20 and and CCONJ k0698625t22 11 21 alkylated alkylate VERB k0698625t22 11 22 protein protein NOUN k0698625t22 11 23 fails fail VERB k0698625t22 11 24 to to PART k0698625t22 11 25 bind bind VERB k0698625t22 11 26 . . PUNCT k0698625t22 12 1 maebl maebl PROPN k0698625t22 12 2 ligand ligand PROPN k0698625t22 12 3 domain domain NOUN k0698625t22 12 4 binding bind VERB k0698625t22 12 5 was be AUX k0698625t22 12 6 dependent dependent ADJ k0698625t22 12 7 on on ADP k0698625t22 12 8 a a DET k0698625t22 12 9 protease protease NOUN k0698625t22 12 10 - - PUNCT k0698625t22 12 11 sensitive sensitive ADJ k0698625t22 12 12 epitope epitope NOUN k0698625t22 12 13 . . PUNCT k0698625t22 13 1 additional additional ADJ k0698625t22 13 2 analysis analysis NOUN k0698625t22 13 3 using use VERB k0698625t22 13 4 a a DET k0698625t22 13 5 panel panel NOUN k0698625t22 13 6 of of ADP k0698625t22 13 7 sulfated sulfated ADJ k0698625t22 13 8 glycosaminoglycans glycosaminoglycan NOUN k0698625t22 13 9 suggested suggest VERB k0698625t22 13 10 an an DET k0698625t22 13 11 essential essential ADJ k0698625t22 13 12 role role NOUN k0698625t22 13 13 for for ADP k0698625t22 13 14 these these DET k0698625t22 13 15 molecules molecule NOUN k0698625t22 13 16 in in ADP k0698625t22 13 17 receptor receptor NOUN k0698625t22 13 18 recognition recognition NOUN k0698625t22 13 19 . . PUNCT