id	sid	tid	token	lemma	pos
nc580k25k42	1	1	t	t	NOUN
nc580k25k42	1	2	cells	cell	NOUN
nc580k25k42	1	3	expressing	express	VERB
nc580k25k42	1	4	t	t	NOUN
nc580k25k42	1	5	cell	cell	NOUN
nc580k25k42	1	6	receptors	receptor	NOUN
nc580k25k42	1	7	(	(	PUNCT
nc580k25k42	1	8	tcrs	tcrs	PROPN
nc580k25k42	1	9	)	)	PUNCT
nc580k25k42	1	10	can	can	AUX
nc580k25k42	1	11	identify	identify	VERB
nc580k25k42	1	12	and	and	CCONJ
nc580k25k42	1	13	eliminate	eliminate	VERB
nc580k25k42	1	14	foreign	foreign	ADJ
nc580k25k42	1	15	pathogens	pathogen	NOUN
nc580k25k42	1	16	by	by	ADP
nc580k25k42	1	17	recognizing	recognize	VERB
nc580k25k42	1	18	peptides	peptide	NOUN
nc580k25k42	1	19	presented	present	VERB
nc580k25k42	1	20	by	by	ADP
nc580k25k42	1	21	major	major	ADJ
nc580k25k42	1	22	histocompatibility	histocompatibility	NOUN
nc580k25k42	1	23	complex	complex	NOUN
nc580k25k42	1	24	(	(	PUNCT
nc580k25k42	1	25	mhc	mhc	NOUN
nc580k25k42	1	26	)	)	PUNCT
nc580k25k42	1	27	proteins	protein	NOUN
nc580k25k42	1	28	.	.	PUNCT
nc580k25k42	2	1	the	the	DET
nc580k25k42	2	2	association	association	NOUN
nc580k25k42	2	3	between	between	ADP
nc580k25k42	2	4	peptide	peptide	NOUN
nc580k25k42	2	5	binding	bind	VERB
nc580k25k42	2	6	affinity	affinity	NOUN
nc580k25k42	2	7	and	and	CCONJ
nc580k25k42	2	8	immunogenicity	immunogenicity	NOUN
nc580k25k42	2	9	has	have	AUX
nc580k25k42	2	10	led	lead	VERB
nc580k25k42	2	11	to	to	ADP
nc580k25k42	2	12	the	the	DET
nc580k25k42	2	13	engineering	engineering	NOUN
nc580k25k42	2	14	of	of	ADP
nc580k25k42	2	15	modified	modify	VERB
nc580k25k42	2	16	peptides	peptide	NOUN
nc580k25k42	2	17	with	with	ADP
nc580k25k42	2	18	improved	improved	ADJ
nc580k25k42	2	19	mhc	mhc	ADV
nc580k25k42	2	20	binding	binding	ADJ
nc580k25k42	2	21	,	,	PUNCT
nc580k25k42	2	22	with	with	ADP
nc580k25k42	2	23	the	the	DET
nc580k25k42	2	24	hope	hope	NOUN
nc580k25k42	2	25	that	that	SCONJ
nc580k25k42	2	26	these	these	DET
nc580k25k42	2	27	peptides	peptide	NOUN
nc580k25k42	2	28	would	would	AUX
nc580k25k42	2	29	be	be	AUX
nc580k25k42	2	30	useful	useful	ADJ
nc580k25k42	2	31	for	for	ADP
nc580k25k42	2	32	eliciting	elicit	VERB
nc580k25k42	2	33	cross	cross	ADJ
nc580k25k42	2	34	-	-	ADJ
nc580k25k42	2	35	reactive	reactive	ADJ
nc580k25k42	2	36	immune	immune	ADJ
nc580k25k42	2	37	responses	response	NOUN
nc580k25k42	2	38	directed	direct	VERB
nc580k25k42	2	39	toward	toward	ADP
nc580k25k42	2	40	their	their	PRON
nc580k25k42	2	41	weak	weak	ADJ
nc580k25k42	2	42	binding	binding	ADJ
nc580k25k42	2	43	,	,	PUNCT
nc580k25k42	2	44	unmodified	unmodified	ADJ
nc580k25k42	2	45	counterparts	counterpart	NOUN
nc580k25k42	2	46	.	.	PUNCT
nc580k25k42	3	1	however	however	ADV
nc580k25k42	3	2	,	,	PUNCT
nc580k25k42	3	3	increasing	increase	VERB
nc580k25k42	3	4	evidence	evidence	NOUN
nc580k25k42	3	5	indicates	indicate	VERB
nc580k25k42	3	6	that	that	SCONJ
nc580k25k42	3	7	tcrs	tcr	NOUN
nc580k25k42	3	8	can	can	AUX
nc580k25k42	3	9	perceive	perceive	VERB
nc580k25k42	3	10	such	such	ADJ
nc580k25k42	3	11	anchor	anchor	NOUN
nc580k25k42	3	12	-	-	PUNCT
nc580k25k42	3	13	modified	modify	VERB
nc580k25k42	3	14	peptides	peptide	NOUN
nc580k25k42	3	15	differently	differently	ADV
nc580k25k42	3	16	than	than	ADP
nc580k25k42	3	17	wild	wild	ADJ
nc580k25k42	3	18	-	-	PUNCT
nc580k25k42	3	19	type	type	NOUN
nc580k25k42	3	20	(	(	PUNCT
nc580k25k42	3	21	wt	wt	NOUN
nc580k25k42	3	22	)	)	PUNCT
nc580k25k42	3	23	peptides.here	peptides.here	PROPN
nc580k25k42	3	24	,	,	PUNCT
nc580k25k42	3	25	i	i	PRON
nc580k25k42	3	26	characterized	characterize	VERB
nc580k25k42	3	27	how	how	SCONJ
nc580k25k42	3	28	different	different	ADJ
nc580k25k42	3	29	tcrs	tcr	NOUN
nc580k25k42	3	30	recognize	recognize	VERB
nc580k25k42	3	31	the	the	DET
nc580k25k42	3	32	wt	wt	PROPN
nc580k25k42	3	33	and	and	CCONJ
nc580k25k42	3	34	anchor	anchor	NOUN
nc580k25k42	3	35	-	-	PUNCT
nc580k25k42	3	36	modified	modify	VERB
nc580k25k42	3	37	variants	variant	NOUN
nc580k25k42	3	38	of	of	ADP
nc580k25k42	3	39	the	the	DET
nc580k25k42	3	40	well	well	ADV
nc580k25k42	3	41	-	-	PUNCT
nc580k25k42	3	42	known	know	VERB
nc580k25k42	3	43	gp100209	gp100209	ADJ
nc580k25k42	3	44	melanoma	melanoma	NOUN
nc580k25k42	3	45	tumor	tumor	NOUN
nc580k25k42	3	46	antigen	antigen	NOUN
nc580k25k42	3	47	.	.	PUNCT
nc580k25k42	4	1	i	i	PRON
nc580k25k42	4	2	show	show	VERB
nc580k25k42	4	3	here	here	ADV
nc580k25k42	4	4	that	that	SCONJ
nc580k25k42	4	5	,	,	PUNCT
nc580k25k42	4	6	unexpectedly	unexpectedly	ADV
nc580k25k42	4	7	,	,	PUNCT
nc580k25k42	4	8	mutational	mutational	ADJ
nc580k25k42	4	9	modifications	modification	NOUN
nc580k25k42	4	10	at	at	ADP
nc580k25k42	4	11	the	the	DET
nc580k25k42	4	12	first	first	ADJ
nc580k25k42	4	13	primary	primary	ADJ
nc580k25k42	4	14	anchor	anchor	NOUN
nc580k25k42	4	15	position	position	NOUN
nc580k25k42	4	16	can	can	AUX
nc580k25k42	4	17	lead	lead	VERB
nc580k25k42	4	18	to	to	ADP
nc580k25k42	4	19	substantially	substantially	ADV
nc580k25k42	4	20	stronger	strong	ADJ
nc580k25k42	4	21	or	or	CCONJ
nc580k25k42	4	22	weaker	weak	ADJ
nc580k25k42	4	23	tcr	tcr	NOUN
nc580k25k42	4	24	binding	bind	VERB
nc580k25k42	4	25	.	.	PUNCT
nc580k25k42	5	1	surprisingly	surprisingly	ADV
nc580k25k42	5	2	,	,	PUNCT
nc580k25k42	5	3	the	the	DET
nc580k25k42	5	4	effect	effect	NOUN
nc580k25k42	5	5	of	of	ADP
nc580k25k42	5	6	anchor	anchor	NOUN
nc580k25k42	5	7	modification	modification	NOUN
nc580k25k42	5	8	can	can	AUX
nc580k25k42	5	9	be	be	AUX
nc580k25k42	5	10	sensed	sense	VERB
nc580k25k42	5	11	by	by	ADP
nc580k25k42	5	12	a	a	DET
nc580k25k42	5	13	tcr	tcr	NOUN
nc580k25k42	5	14	at	at	ADP
nc580k25k42	5	15	regions	region	NOUN
nc580k25k42	5	16	far	far	ADV
nc580k25k42	5	17	from	from	ADP
nc580k25k42	5	18	the	the	DET
nc580k25k42	5	19	site	site	NOUN
nc580k25k42	5	20	of	of	ADP
nc580k25k42	5	21	modification	modification	NOUN
nc580k25k42	5	22	,	,	PUNCT
nc580k25k42	5	23	indicating	indicate	VERB
nc580k25k42	5	24	a	a	DET
nc580k25k42	5	25	through	through	ADP
nc580k25k42	5	26	-	-	PUNCT
nc580k25k42	5	27	protein	protein	NOUN
nc580k25k42	5	28	mechanism	mechanism	NOUN
nc580k25k42	5	29	in	in	ADP
nc580k25k42	5	30	which	which	PRON
nc580k25k42	5	31	the	the	DET
nc580k25k42	5	32	anchor	anchor	NOUN
nc580k25k42	5	33	residue	residue	NOUN
nc580k25k42	5	34	serves	serve	VERB
nc580k25k42	5	35	as	as	ADP
nc580k25k42	5	36	an	an	DET
nc580k25k42	5	37	allosteric	allosteric	NOUN
nc580k25k42	5	38	modulator	modulator	NOUN
nc580k25k42	5	39	of	of	ADP
nc580k25k42	5	40	tcr	tcr	NOUN
nc580k25k42	5	41	binding.of	binding.of	NUM
nc580k25k42	5	42	the	the	DET
nc580k25k42	5	43	panel	panel	NOUN
nc580k25k42	5	44	of	of	ADP
nc580k25k42	5	45	tcrs	tcrs	PROPN
nc580k25k42	5	46	,	,	PUNCT
nc580k25k42	5	47	the	the	DET
nc580k25k42	5	48	silv44	silv44	NOUN
nc580k25k42	5	49	receptor	receptor	NOUN
nc580k25k42	5	50	has	have	AUX
nc580k25k42	5	51	been	be	AUX
nc580k25k42	5	52	proposed	propose	VERB
nc580k25k42	5	53	as	as	ADP
nc580k25k42	5	54	a	a	DET
nc580k25k42	5	55	clinical	clinical	ADJ
nc580k25k42	5	56	candidate	candidate	NOUN
nc580k25k42	5	57	for	for	ADP
nc580k25k42	5	58	immunotherapy	immunotherapy	NOUN
nc580k25k42	5	59	of	of	ADP
nc580k25k42	5	60	melanoma	melanoma	NOUN
nc580k25k42	5	61	.	.	PUNCT
nc580k25k42	6	1	finding	find	VERB
nc580k25k42	6	2	that	that	SCONJ
nc580k25k42	6	3	gp100209	gp100209	NOUN
nc580k25k42	6	4	-	-	PUNCT
nc580k25k42	6	5	specific	specific	ADJ
nc580k25k42	6	6	tcrs	tcrs	NOUN
nc580k25k42	6	7	are	be	AUX
nc580k25k42	6	8	sensitive	sensitive	ADJ
nc580k25k42	6	9	to	to	ADP
nc580k25k42	6	10	peptide	peptide	NOUN
nc580k25k42	6	11	anchor	anchor	NOUN
nc580k25k42	6	12	modifications	modification	NOUN
nc580k25k42	6	13	,	,	PUNCT
nc580k25k42	6	14	i	i	PRON
nc580k25k42	6	15	show	show	VERB
nc580k25k42	6	16	that	that	SCONJ
nc580k25k42	6	17	,	,	PUNCT
nc580k25k42	6	18	in	in	ADP
nc580k25k42	6	19	contrast	contrast	NOUN
nc580k25k42	6	20	to	to	ADP
nc580k25k42	6	21	previously	previously	ADV
nc580k25k42	6	22	published	publish	VERB
nc580k25k42	6	23	work	work	NOUN
nc580k25k42	6	24	,	,	PUNCT
nc580k25k42	6	25	the	the	DET
nc580k25k42	6	26	enhanced	enhance	VERB
nc580k25k42	6	27	tumor	tumor	NOUN
nc580k25k42	6	28	control	control	NOUN
nc580k25k42	6	29	properties	property	NOUN
nc580k25k42	6	30	of	of	ADP
nc580k25k42	6	31	the	the	DET
nc580k25k42	6	32	silv44	silv44	NOUN
nc580k25k42	6	33	tcr	tcr	NOUN
nc580k25k42	6	34	are	be	AUX
nc580k25k42	6	35	a	a	DET
nc580k25k42	6	36	result	result	NOUN
nc580k25k42	6	37	of	of	ADP
nc580k25k42	6	38	strong	strong	ADJ
nc580k25k42	6	39	tcr	tcr	NOUN
nc580k25k42	6	40	binding	bind	VERB
nc580k25k42	6	41	affinity	affinity	NOUN
nc580k25k42	6	42	to	to	ADP
nc580k25k42	6	43	the	the	DET
nc580k25k42	6	44	wt	wt	PROPN
nc580k25k42	6	45	peptide	peptide	PROPN
nc580k25k42	6	46	antigen	antigen	PROPN
nc580k25k42	6	47	.	.	PUNCT
nc580k25k42	7	1	overall	overall	ADJ
nc580k25k42	7	2	,	,	PUNCT
nc580k25k42	7	3	my	my	PRON
nc580k25k42	7	4	studies	study	NOUN
nc580k25k42	7	5	highlight	highlight	VERB
nc580k25k42	7	6	how	how	SCONJ
nc580k25k42	7	7	subtle	subtle	ADJ
nc580k25k42	7	8	changes	change	NOUN
nc580k25k42	7	9	at	at	ADP
nc580k25k42	7	10	a	a	DET
nc580k25k42	7	11	primary	primary	ADJ
nc580k25k42	7	12	peptide	peptide	NOUN
nc580k25k42	7	13	anchor	anchor	NOUN
nc580k25k42	7	14	position	position	NOUN
nc580k25k42	7	15	can	can	AUX
nc580k25k42	7	16	have	have	VERB
nc580k25k42	7	17	dramatic	dramatic	ADJ
nc580k25k42	7	18	and	and	CCONJ
nc580k25k42	7	19	tcr	tcr	PROPN
nc580k25k42	7	20	-	-	PUNCT
nc580k25k42	7	21	dependent	dependent	ADJ
nc580k25k42	7	22	consequences	consequence	NOUN
nc580k25k42	7	23	and	and	CCONJ
nc580k25k42	7	24	should	should	AUX
nc580k25k42	7	25	help	help	VERB
nc580k25k42	7	26	guide	guide	VERB
nc580k25k42	7	27	the	the	DET
nc580k25k42	7	28	development	development	NOUN
nc580k25k42	7	29	of	of	ADP
nc580k25k42	7	30	tcr	tcr	PROPN
nc580k25k42	7	31	and	and	CCONJ
nc580k25k42	7	32	t	t	PROPN
nc580k25k42	7	33	cell	cell	NOUN
nc580k25k42	7	34	-	-	PUNCT
nc580k25k42	7	35	based	base	VERB
nc580k25k42	7	36	therapeutics	therapeutic	NOUN
nc580k25k42	7	37	.	.	PUNCT