id sid tid token lemma pos nc580k25n09 1 1 zebrafish zebrafish PROPN nc580k25n09 1 2 ( ( PUNCT nc580k25n09 1 3 danio danio PROPN nc580k25n09 1 4 rerio rerio PROPN nc580k25n09 1 5 ) ) PUNCT nc580k25n09 1 6 have have VERB nc580k25n09 1 7 the the DET nc580k25n09 1 8 natural natural ADJ nc580k25n09 1 9 capacity capacity NOUN nc580k25n09 1 10 to to PART nc580k25n09 1 11 regenerate regenerate VERB nc580k25n09 1 12 all all DET nc580k25n09 1 13 neuronal neuronal ADJ nc580k25n09 1 14 cell cell NOUN nc580k25n09 1 15 types type NOUN nc580k25n09 1 16 of of ADP nc580k25n09 1 17 the the DET nc580k25n09 1 18 retina retina NOUN nc580k25n09 1 19 that that PRON nc580k25n09 1 20 are be AUX nc580k25n09 1 21 lost lose VERB nc580k25n09 1 22 following follow VERB nc580k25n09 1 23 injury injury NOUN nc580k25n09 1 24 through through ADP nc580k25n09 1 25 the the DET nc580k25n09 1 26 reprogramming reprogramming NOUN nc580k25n09 1 27 and and CCONJ nc580k25n09 1 28 proliferation proliferation NOUN nc580k25n09 1 29 of of ADP nc580k25n09 1 30 the the DET nc580k25n09 1 31 müller müller NOUN nc580k25n09 1 32 glia glia NOUN nc580k25n09 1 33 . . PUNCT nc580k25n09 2 1 the the DET nc580k25n09 2 2 mechanism mechanism NOUN nc580k25n09 2 3 regulating regulate VERB nc580k25n09 2 4 the the DET nc580k25n09 2 5 retinal retinal ADJ nc580k25n09 2 6 regeneration regeneration NOUN nc580k25n09 2 7 is be AUX nc580k25n09 2 8 still still ADV nc580k25n09 2 9 elusive elusive ADJ nc580k25n09 2 10 . . PUNCT nc580k25n09 3 1 recently recently ADV nc580k25n09 3 2 , , PUNCT nc580k25n09 3 3 the the DET nc580k25n09 3 4 hippo hippo PROPN nc580k25n09 3 5 pathway pathway NOUN nc580k25n09 3 6 effector effector PROPN nc580k25n09 3 7 yap yap PROPN nc580k25n09 3 8 has have AUX nc580k25n09 3 9 been be AUX nc580k25n09 3 10 identified identify VERB nc580k25n09 3 11 play play NOUN nc580k25n09 3 12 roles role NOUN nc580k25n09 3 13 in in ADP nc580k25n09 3 14 regulating regulate VERB nc580k25n09 3 15 the the DET nc580k25n09 3 16 proliferation proliferation NOUN nc580k25n09 3 17 müller müller NOUN nc580k25n09 3 18 glia glia NOUN nc580k25n09 3 19 in in ADP nc580k25n09 3 20 mice mouse NOUN nc580k25n09 3 21 . . PUNCT nc580k25n09 4 1 our our PRON nc580k25n09 4 2 previous previous ADJ nc580k25n09 4 3 data datum NOUN nc580k25n09 4 4 also also ADV nc580k25n09 4 5 showed show VERB nc580k25n09 4 6 the the DET nc580k25n09 4 7 yap1 yap1 PROPN nc580k25n09 4 8 is be AUX nc580k25n09 4 9 required require VERB nc580k25n09 4 10 for for ADP nc580k25n09 4 11 reprogramming reprogramming NOUN nc580k25n09 4 12 and and CCONJ nc580k25n09 4 13 proliferation proliferation NOUN nc580k25n09 4 14 of of ADP nc580k25n09 4 15 the the DET nc580k25n09 4 16 müller müller NOUN nc580k25n09 4 17 glia glia NOUN nc580k25n09 4 18 . . PUNCT nc580k25n09 5 1 however however ADV nc580k25n09 5 2 , , PUNCT nc580k25n09 5 3 previous previous ADJ nc580k25n09 5 4 publications publication NOUN nc580k25n09 5 5 focused focus VERB nc580k25n09 5 6 on on ADP nc580k25n09 5 7 the the DET nc580k25n09 5 8 expression expression NOUN nc580k25n09 5 9 of of ADP nc580k25n09 5 10 the the DET nc580k25n09 5 11 hippo hippo PROPN nc580k25n09 5 12 pathway pathway NOUN nc580k25n09 5 13 effectors effector VERB nc580k25n09 5 14 yap1 yap1 PROPN nc580k25n09 5 15 and and CCONJ nc580k25n09 5 16 taz taz PROPN nc580k25n09 5 17 , , PUNCT nc580k25n09 5 18 largely largely ADV nc580k25n09 5 19 ignoring ignore VERB nc580k25n09 5 20 the the DET nc580k25n09 5 21 other other ADJ nc580k25n09 5 22 hippo hippo NOUN nc580k25n09 5 23 pathway pathway NOUN nc580k25n09 5 24 genes gene NOUN nc580k25n09 5 25 . . PUNCT nc580k25n09 6 1 in in ADP nc580k25n09 6 2 this this DET nc580k25n09 6 3 study study NOUN nc580k25n09 6 4 , , PUNCT nc580k25n09 6 5 i i PRON nc580k25n09 6 6 dissected dissect VERB nc580k25n09 6 7 the the DET nc580k25n09 6 8 functions function NOUN nc580k25n09 6 9 of of ADP nc580k25n09 6 10 several several ADJ nc580k25n09 6 11 core core NOUN nc580k25n09 6 12 hippo hippo NOUN nc580k25n09 6 13 pathway pathway NOUN nc580k25n09 6 14 genes gene NOUN nc580k25n09 6 15 during during ADP nc580k25n09 6 16 retinal retinal ADJ nc580k25n09 6 17 damage damage NOUN nc580k25n09 6 18 and and CCONJ nc580k25n09 6 19 regeneration regeneration NOUN nc580k25n09 6 20 , , PUNCT nc580k25n09 6 21 which which PRON nc580k25n09 6 22 included include VERB nc580k25n09 6 23 the the DET nc580k25n09 6 24 genes gene NOUN nc580k25n09 6 25 encoding encode VERB nc580k25n09 6 26 three three NUM nc580k25n09 6 27 kinases kinase NOUN nc580k25n09 6 28 stk3 stk3 PROPN nc580k25n09 6 29 , , PUNCT nc580k25n09 6 30 lats1 lats1 PROPN nc580k25n09 6 31 , , PUNCT nc580k25n09 6 32 lats2 lats2 PROPN nc580k25n09 6 33 , , PUNCT nc580k25n09 6 34 two two NUM nc580k25n09 6 35 transcriptional transcriptional NOUN nc580k25n09 6 36 co co NOUN nc580k25n09 6 37 - - NOUN nc580k25n09 6 38 activators activator VERB nc580k25n09 6 39 yap1 yap1 PROPN nc580k25n09 6 40 and and CCONJ nc580k25n09 6 41 taz taz PROPN nc580k25n09 6 42 , , PUNCT nc580k25n09 6 43 four four NUM nc580k25n09 6 44 transcription transcription NOUN nc580k25n09 6 45 factors factor NOUN nc580k25n09 6 46 tead1a tead1a SPACE nc580k25n09 6 47 , , PUNCT nc580k25n09 6 48 tead1b tead1b SPACE nc580k25n09 6 49 , , PUNCT nc580k25n09 6 50 tead3a tead3a SPACE nc580k25n09 6 51 , , PUNCT nc580k25n09 6 52 tead3b.in tead3b.in PRON nc580k25n09 6 53 this this DET nc580k25n09 6 54 research research NOUN nc580k25n09 6 55 , , PUNCT nc580k25n09 6 56 i i PRON nc580k25n09 6 57 first first ADV nc580k25n09 6 58 identified identify VERB nc580k25n09 6 59 another another DET nc580k25n09 6 60 two two NUM nc580k25n09 6 61 hippo hippo NOUN nc580k25n09 6 62 pathway pathway NOUN nc580k25n09 6 63 components component NOUN nc580k25n09 6 64 tead1a tead1a SYM nc580k25n09 6 65 and and CCONJ nc580k25n09 6 66 tead3a tead3a X nc580k25n09 6 67 are be AUX nc580k25n09 6 68 required require VERB nc580k25n09 6 69 for for ADP nc580k25n09 6 70 müller müller NOUN nc580k25n09 6 71 glia glia NOUN nc580k25n09 6 72 reprogramming reprogramming NOUN nc580k25n09 6 73 via via ADP nc580k25n09 6 74 regulating regulate VERB nc580k25n09 6 75 sox2 sox2 NOUN nc580k25n09 6 76 expression expression NOUN nc580k25n09 6 77 . . PUNCT nc580k25n09 7 1 and and CCONJ nc580k25n09 7 2 i i PRON nc580k25n09 7 3 first first ADV nc580k25n09 7 4 identified identify VERB nc580k25n09 7 5 the the DET nc580k25n09 7 6 two two NUM nc580k25n09 7 7 kinases kinase NOUN nc580k25n09 7 8 lats1 lats1 PROPN nc580k25n09 7 9 and and CCONJ nc580k25n09 7 10 lats2 lats2 ADJ nc580k25n09 7 11 , , PUNCT nc580k25n09 7 12 and and CCONJ nc580k25n09 7 13 four four NUM nc580k25n09 7 14 tead tead NOUN nc580k25n09 7 15 transcriptional transcriptional NOUN nc580k25n09 7 16 factors factor NOUN nc580k25n09 7 17 played play VERB nc580k25n09 7 18 distinct distinct ADJ nc580k25n09 7 19 roles role NOUN nc580k25n09 7 20 in in ADP nc580k25n09 7 21 regulating regulate VERB nc580k25n09 7 22 the the DET nc580k25n09 7 23 proliferation proliferation NOUN nc580k25n09 7 24 of of ADP nc580k25n09 7 25 müller müller NOUN nc580k25n09 7 26 glia glia NOUN nc580k25n09 7 27 and and CCONJ nc580k25n09 7 28 neuronal neuronal ADJ nc580k25n09 7 29 progenitor progenitor NOUN nc580k25n09 7 30 cells cell NOUN nc580k25n09 7 31 . . PUNCT nc580k25n09 8 1 interestingly interestingly ADV nc580k25n09 8 2 , , PUNCT nc580k25n09 8 3 i i PRON nc580k25n09 8 4 identified identify VERB nc580k25n09 8 5 the the DET nc580k25n09 8 6 mechanism mechanism NOUN nc580k25n09 8 7 of of ADP nc580k25n09 8 8 lats2 lats2 ADJ nc580k25n09 8 9 and and CCONJ nc580k25n09 8 10 stk3 stk3 PROPN nc580k25n09 8 11 maintaining maintain VERB nc580k25n09 8 12 the the DET nc580k25n09 8 13 quiescent quiescent ADJ nc580k25n09 8 14 exit exit NOUN nc580k25n09 8 15 of of ADP nc580k25n09 8 16 müller müller NOUN nc580k25n09 8 17 glia glia NOUN nc580k25n09 8 18 via via ADP nc580k25n09 8 19 repressing repress VERB nc580k25n09 8 20 the the DET nc580k25n09 8 21 notch3 notch3 ADJ nc580k25n09 8 22 inner inner ADJ nc580k25n09 8 23 cellular cellular ADJ nc580k25n09 8 24 domain domain NOUN nc580k25n09 8 25 ( ( PUNCT nc580k25n09 8 26 n3icd n3icd NOUN nc580k25n09 8 27 ) ) PUNCT nc580k25n09 8 28 expression expression NOUN nc580k25n09 8 29 . . PUNCT nc580k25n09 9 1 combining combine VERB nc580k25n09 9 2 with with ADP nc580k25n09 9 3 rescue rescue NOUN nc580k25n09 9 4 experiments experiment NOUN nc580k25n09 9 5 , , PUNCT nc580k25n09 9 6 the the DET nc580k25n09 9 7 exciting exciting ADJ nc580k25n09 9 8 results result NOUN nc580k25n09 9 9 indicate indicate VERB nc580k25n09 9 10 the the DET nc580k25n09 9 11 notch3 notch3 ADJ nc580k25n09 9 12 icd icd NOUN nc580k25n09 9 13 is be AUX nc580k25n09 9 14 a a DET nc580k25n09 9 15 node node NOUN nc580k25n09 9 16 at at ADP nc580k25n09 9 17 the the DET nc580k25n09 9 18 crosstalk crosstalk NOUN nc580k25n09 9 19 of of ADP nc580k25n09 9 20 the the DET nc580k25n09 9 21 hippo hippo ADJ nc580k25n09 9 22 pathway pathway NOUN nc580k25n09 9 23 and and CCONJ nc580k25n09 9 24 the the DET nc580k25n09 9 25 notch notch ADJ nc580k25n09 9 26 pathway pathway NOUN nc580k25n09 9 27 in in ADP nc580k25n09 9 28 regulating regulate VERB nc580k25n09 9 29 müller müller NOUN nc580k25n09 9 30 glia glia NOUN nc580k25n09 9 31 quiescent quiescent ADJ nc580k25n09 9 32 exit exit NOUN nc580k25n09 9 33 . . PUNCT nc580k25n09 10 1 i i PRON nc580k25n09 10 2 further far ADV nc580k25n09 10 3 analyzed analyze VERB nc580k25n09 10 4 the the DET nc580k25n09 10 5 single single ADJ nc580k25n09 10 6 - - PUNCT nc580k25n09 10 7 cell cell NOUN nc580k25n09 10 8 data datum NOUN nc580k25n09 10 9 sets set NOUN nc580k25n09 10 10 and and CCONJ nc580k25n09 10 11 identified identify VERB nc580k25n09 10 12 the the DET nc580k25n09 10 13 hippo hippo PROPN nc580k25n09 10 14 - - PUNCT nc580k25n09 10 15 adam10 adam10 SPACE nc580k25n09 10 16 - - PUNCT nc580k25n09 10 17 notch notch ADJ nc580k25n09 10 18 - - PUNCT nc580k25n09 10 19 notch3 notch3 ADJ nc580k25n09 10 20 icd icd NOUN nc580k25n09 10 21 axis axis NOUN nc580k25n09 10 22 in in ADP nc580k25n09 10 23 regulating regulate VERB nc580k25n09 10 24 müller müller NOUN nc580k25n09 10 25 glia glia NOUN nc580k25n09 10 26 proliferation proliferation NOUN nc580k25n09 10 27 . . PUNCT nc580k25n09 11 1 the the DET nc580k25n09 11 2 novel novel ADJ nc580k25n09 11 3 results result NOUN nc580k25n09 11 4 indicate indicate VERB nc580k25n09 11 5 in in ADP nc580k25n09 11 6 müller müller NOUN nc580k25n09 11 7 glia glia NOUN nc580k25n09 11 8 during during ADP nc580k25n09 11 9 retinal retinal ADJ nc580k25n09 11 10 regeneration regeneration NOUN nc580k25n09 11 11 : : PUNCT nc580k25n09 11 12 the the DET nc580k25n09 11 13 hippo hippo PROPN nc580k25n09 11 14 pathway pathway NOUN nc580k25n09 11 15 and and CCONJ nc580k25n09 11 16 the the DET nc580k25n09 11 17 notch notch ADJ nc580k25n09 11 18 pathway pathway NOUN nc580k25n09 11 19 can can AUX nc580k25n09 11 20 interact interact VERB nc580k25n09 11 21 via via ADP nc580k25n09 11 22 a a DET nc580k25n09 11 23 protease protease NOUN nc580k25n09 11 24 cleavage cleavage NOUN nc580k25n09 11 25 mechanism mechanism NOUN nc580k25n09 11 26 , , PUNCT nc580k25n09 11 27 but but CCONJ nc580k25n09 11 28 not not PART nc580k25n09 11 29 through through ADP nc580k25n09 11 30 the the DET nc580k25n09 11 31 ligands ligand NOUN nc580k25n09 11 32 / / SYM nc580k25n09 11 33 receptors receptor NOUN nc580k25n09 11 34 mechanism mechanism NOUN nc580k25n09 11 35 , , PUNCT nc580k25n09 11 36 which which PRON nc580k25n09 11 37 is be AUX nc580k25n09 11 38 a a DET nc580k25n09 11 39 regular regular ADJ nc580k25n09 11 40 hippo hippo ADJ nc580k25n09 11 41 - - PUNCT nc580k25n09 11 42 notch notch NOUN nc580k25n09 11 43 crosstalk crosstalk NOUN nc580k25n09 11 44 mechanism mechanism NOUN nc580k25n09 11 45 . . PUNCT