id sid tid token lemma pos p8418k74q1b 1 1 in in ADP p8418k74q1b 1 2 this this DET p8418k74q1b 1 3 dissertation dissertation NOUN p8418k74q1b 1 4 , , PUNCT p8418k74q1b 1 5 i i PRON p8418k74q1b 1 6 address address VERB p8418k74q1b 1 7 the the DET p8418k74q1b 1 8 significance significance NOUN p8418k74q1b 1 9 of of ADP p8418k74q1b 1 10 signal signal ADJ p8418k74q1b 1 11 transduction transduction NOUN p8418k74q1b 1 12 cascades cascade NOUN p8418k74q1b 1 13 during during ADP p8418k74q1b 1 14 leishmania leishmania PROPN p8418k74q1b 1 15 parasite parasite NOUN p8418k74q1b 1 16 differentiation differentiation NOUN p8418k74q1b 1 17 for for ADP p8418k74q1b 1 18 the the DET p8418k74q1b 1 19 purpose purpose NOUN p8418k74q1b 1 20 of of ADP p8418k74q1b 1 21 identifying identify VERB p8418k74q1b 1 22 potential potential ADJ p8418k74q1b 1 23 drug drug NOUN p8418k74q1b 1 24 targets target NOUN p8418k74q1b 1 25 to to PART p8418k74q1b 1 26 be be AUX p8418k74q1b 1 27 used use VERB p8418k74q1b 1 28 for for ADP p8418k74q1b 1 29 the the DET p8418k74q1b 1 30 treatment treatment NOUN p8418k74q1b 1 31 of of ADP p8418k74q1b 1 32 leishmaniasis leishmaniasis NOUN p8418k74q1b 1 33 , , PUNCT p8418k74q1b 1 34 a a DET p8418k74q1b 1 35 disease disease NOUN p8418k74q1b 1 36 characterized characterize VERB p8418k74q1b 1 37 by by ADP p8418k74q1b 1 38 a a DET p8418k74q1b 1 39 spectrum spectrum NOUN p8418k74q1b 1 40 of of ADP p8418k74q1b 1 41 clinical clinical ADJ p8418k74q1b 1 42 manifestations manifestation NOUN p8418k74q1b 1 43 ranging range VERB p8418k74q1b 1 44 from from ADP p8418k74q1b 1 45 ulcerative ulcerative ADJ p8418k74q1b 1 46 skin skin NOUN p8418k74q1b 1 47 lesions lesion NOUN p8418k74q1b 1 48 to to ADP p8418k74q1b 1 49 fatal fatal ADJ p8418k74q1b 1 50 visceral visceral NOUN p8418k74q1b 1 51 infections infection NOUN p8418k74q1b 1 52 . . PUNCT p8418k74q1b 2 1 to to ADP p8418k74q1b 2 2 date date NOUN p8418k74q1b 2 3 , , PUNCT p8418k74q1b 2 4 few few ADJ p8418k74q1b 2 5 anti anti ADJ p8418k74q1b 2 6 - - ADJ p8418k74q1b 2 7 leishmanial leishmanial ADJ p8418k74q1b 2 8 drugs drug NOUN p8418k74q1b 2 9 exist exist VERB p8418k74q1b 2 10 and and CCONJ p8418k74q1b 2 11 most most ADJ p8418k74q1b 2 12 risk risk NOUN p8418k74q1b 2 13 becoming become VERB p8418k74q1b 2 14 ineffective ineffective ADJ p8418k74q1b 2 15 due due ADP p8418k74q1b 2 16 to to ADP p8418k74q1b 2 17 emerging emerge VERB p8418k74q1b 2 18 resistances resistance NOUN p8418k74q1b 2 19 ; ; PUNCT p8418k74q1b 2 20 therefore therefore ADV p8418k74q1b 2 21 , , PUNCT p8418k74q1b 2 22 new new ADJ p8418k74q1b 2 23 drugs drug NOUN p8418k74q1b 2 24 are be AUX p8418k74q1b 2 25 urgently urgently ADV p8418k74q1b 2 26 needed need VERB p8418k74q1b 2 27 . . PUNCT p8418k74q1b 3 1 during during ADP p8418k74q1b 3 2 the the DET p8418k74q1b 3 3 infectious infectious ADJ p8418k74q1b 3 4 cycle cycle NOUN p8418k74q1b 3 5 , , PUNCT p8418k74q1b 3 6 leishmania leishmania PROPN p8418k74q1b 3 7 differentiates differentiate VERB p8418k74q1b 3 8 from from ADP p8418k74q1b 3 9 extracellular extracellular ADJ p8418k74q1b 3 10 promastigotes promastigote NOUN p8418k74q1b 3 11 in in ADP p8418k74q1b 3 12 sandflies sandfly NOUN p8418k74q1b 3 13 to to ADP p8418k74q1b 3 14 pathogenic pathogenic ADJ p8418k74q1b 3 15 intracellular intracellular ADJ p8418k74q1b 3 16 amastigotes amastigote NOUN p8418k74q1b 3 17 in in ADP p8418k74q1b 3 18 mammalian mammalian PROPN p8418k74q1b 3 19 hosts host NOUN p8418k74q1b 3 20 . . PUNCT p8418k74q1b 4 1 differentiation differentiation NOUN p8418k74q1b 4 2 is be AUX p8418k74q1b 4 3 triggered trigger VERB p8418k74q1b 4 4 by by ADP p8418k74q1b 4 5 changes change NOUN p8418k74q1b 4 6 in in ADP p8418k74q1b 4 7 environmental environmental ADJ p8418k74q1b 4 8 signals signal NOUN p8418k74q1b 4 9 , , PUNCT p8418k74q1b 4 10 namely namely ADV p8418k74q1b 4 11 ph ph NOUN p8418k74q1b 4 12 and and CCONJ p8418k74q1b 4 13 temperature temperature NOUN p8418k74q1b 4 14 , , PUNCT p8418k74q1b 4 15 which which PRON p8418k74q1b 4 16 are be AUX p8418k74q1b 4 17 relayed relay VERB p8418k74q1b 4 18 through through ADP p8418k74q1b 4 19 signal signal NOUN p8418k74q1b 4 20 transduction transduction NOUN p8418k74q1b 4 21 pathways pathway NOUN p8418k74q1b 4 22 via via ADP p8418k74q1b 4 23 reversible reversible ADJ p8418k74q1b 4 24 phosphorylation phosphorylation NOUN p8418k74q1b 4 25 of of ADP p8418k74q1b 4 26 kinases kinase NOUN p8418k74q1b 4 27 and and CCONJ p8418k74q1b 4 28 phosphatases phosphatase NOUN p8418k74q1b 4 29 . . PUNCT p8418k74q1b 5 1 compared compare VERB p8418k74q1b 5 2 to to ADP p8418k74q1b 5 3 higher high ADJ p8418k74q1b 5 4 eukaryotes eukaryote NOUN p8418k74q1b 5 5 , , PUNCT p8418k74q1b 5 6 our our PRON p8418k74q1b 5 7 knowledge knowledge NOUN p8418k74q1b 5 8 of of ADP p8418k74q1b 5 9 these these DET p8418k74q1b 5 10 signaling signal VERB p8418k74q1b 5 11 molecules molecule NOUN p8418k74q1b 5 12 in in ADP p8418k74q1b 5 13 leishmania leishmania PROPN p8418k74q1b 5 14 is be AUX p8418k74q1b 5 15 scarce scarce ADJ p8418k74q1b 5 16 despite despite SCONJ p8418k74q1b 5 17 their their PRON p8418k74q1b 5 18 essential essential ADJ p8418k74q1b 5 19 roles role NOUN p8418k74q1b 5 20 in in ADP p8418k74q1b 5 21 the the DET p8418k74q1b 5 22 biology biology NOUN p8418k74q1b 5 23 of of ADP p8418k74q1b 5 24 the the DET p8418k74q1b 5 25 parasite parasite NOUN p8418k74q1b 5 26 . . PUNCT p8418k74q1b 6 1 mitogen mitogen NOUN p8418k74q1b 6 2 - - PUNCT p8418k74q1b 6 3 activated activate VERB p8418k74q1b 6 4 protein protein NOUN p8418k74q1b 6 5 kinases kinase NOUN p8418k74q1b 6 6 ( ( PUNCT p8418k74q1b 6 7 mapks mapks PROPN p8418k74q1b 6 8 ) ) PUNCT p8418k74q1b 6 9 are be AUX p8418k74q1b 6 10 conserved conserve VERB p8418k74q1b 6 11 virtually virtually ADV p8418k74q1b 6 12 across across ADP p8418k74q1b 6 13 all all DET p8418k74q1b 6 14 eukaryotic eukaryotic ADJ p8418k74q1b 6 15 organisms organism NOUN p8418k74q1b 6 16 . . PUNCT p8418k74q1b 7 1 previous previous ADJ p8418k74q1b 7 2 insight insight NOUN p8418k74q1b 7 3 into into ADP p8418k74q1b 7 4 the the DET p8418k74q1b 7 5 mapk mapk PROPN p8418k74q1b 7 6 pathway pathway NOUN p8418k74q1b 7 7 in in ADP p8418k74q1b 7 8 leishmania leishmania PROPN p8418k74q1b 7 9 revealed reveal VERB p8418k74q1b 7 10 a a DET p8418k74q1b 7 11 downstream downstream ADJ p8418k74q1b 7 12 target target NOUN p8418k74q1b 7 13 of of ADP p8418k74q1b 7 14 mapk7 mapk7 PROPN p8418k74q1b 7 15 , , PUNCT p8418k74q1b 7 16 identified identify VERB p8418k74q1b 7 17 as as ADP p8418k74q1b 7 18 lmapa2g4 lmapa2g4 NUM p8418k74q1b 7 19 . . PUNCT p8418k74q1b 8 1 upon upon SCONJ p8418k74q1b 8 2 investigating investigate VERB p8418k74q1b 8 3 lmapa2g4 lmapa2g4 PROPN p8418k74q1b 8 4 , , PUNCT p8418k74q1b 8 5 we we PRON p8418k74q1b 8 6 found find VERB p8418k74q1b 8 7 it it PRON p8418k74q1b 8 8 to to PART p8418k74q1b 8 9 be be AUX p8418k74q1b 8 10 an an DET p8418k74q1b 8 11 essential essential ADJ p8418k74q1b 8 12 gene gene NOUN p8418k74q1b 8 13 potentially potentially ADV p8418k74q1b 8 14 indicated indicate VERB p8418k74q1b 8 15 in in ADP p8418k74q1b 8 16 fundamental fundamental ADJ p8418k74q1b 8 17 biological biological ADJ p8418k74q1b 8 18 mechanisms mechanism NOUN p8418k74q1b 8 19 , , PUNCT p8418k74q1b 8 20 such such ADJ p8418k74q1b 8 21 as as ADP p8418k74q1b 8 22 translation translation NOUN p8418k74q1b 8 23 , , PUNCT p8418k74q1b 8 24 therefore therefore ADV p8418k74q1b 8 25 making make VERB p8418k74q1b 8 26 it it PRON p8418k74q1b 8 27 an an DET p8418k74q1b 8 28 attractive attractive ADJ p8418k74q1b 8 29 target target NOUN p8418k74q1b 8 30 for for ADP p8418k74q1b 8 31 therapeutic therapeutic ADJ p8418k74q1b 8 32 intervention intervention NOUN p8418k74q1b 8 33 . . PUNCT p8418k74q1b 9 1 though though SCONJ p8418k74q1b 9 2 protein protein NOUN p8418k74q1b 9 3 kinases kinase NOUN p8418k74q1b 9 4 , , PUNCT p8418k74q1b 9 5 and and CCONJ p8418k74q1b 9 6 their their PRON p8418k74q1b 9 7 downstream downstream ADJ p8418k74q1b 9 8 targets target NOUN p8418k74q1b 9 9 , , PUNCT p8418k74q1b 9 10 have have AUX p8418k74q1b 9 11 been be AUX p8418k74q1b 9 12 more more ADV p8418k74q1b 9 13 actively actively ADV p8418k74q1b 9 14 studied study VERB p8418k74q1b 9 15 for for ADP p8418k74q1b 9 16 the the DET p8418k74q1b 9 17 potential potential ADJ p8418k74q1b 9 18 development development NOUN p8418k74q1b 9 19 of of ADP p8418k74q1b 9 20 anti anti ADJ p8418k74q1b 9 21 - - ADJ p8418k74q1b 9 22 parasitic parasitic ADJ p8418k74q1b 9 23 therapeutics therapeutic NOUN p8418k74q1b 9 24 , , PUNCT p8418k74q1b 9 25 our our PRON p8418k74q1b 9 26 understanding understanding NOUN p8418k74q1b 9 27 of of ADP p8418k74q1b 9 28 the the DET p8418k74q1b 9 29 biology biology NOUN p8418k74q1b 9 30 of of ADP p8418k74q1b 9 31 protein protein NOUN p8418k74q1b 9 32 phosphatases phosphatase NOUN p8418k74q1b 9 33 in in ADP p8418k74q1b 9 34 leishmania leishmania PROPN p8418k74q1b 9 35 is be AUX p8418k74q1b 9 36 poor poor ADJ p8418k74q1b 9 37 despite despite SCONJ p8418k74q1b 9 38 their their PRON p8418k74q1b 9 39 implication implication NOUN p8418k74q1b 9 40 in in ADP p8418k74q1b 9 41 critical critical ADJ p8418k74q1b 9 42 post post ADJ p8418k74q1b 9 43 - - ADJ p8418k74q1b 9 44 translational translational ADJ p8418k74q1b 9 45 modifications modification NOUN p8418k74q1b 9 46 and and CCONJ p8418k74q1b 9 47 differentiation differentiation NOUN p8418k74q1b 9 48 . . PUNCT p8418k74q1b 10 1 approximately approximately ADV p8418k74q1b 10 2 96 96 NUM p8418k74q1b 10 3 - - SYM p8418k74q1b 10 4 99 99 NUM p8418k74q1b 10 5 % % NOUN p8418k74q1b 10 6 of of ADP p8418k74q1b 10 7 proteins protein NOUN p8418k74q1b 10 8 in in ADP p8418k74q1b 10 9 eukaryotes eukaryote NOUN p8418k74q1b 10 10 are be AUX p8418k74q1b 10 11 phosphorylated phosphorylate VERB p8418k74q1b 10 12 on on ADP p8418k74q1b 10 13 serine serine NOUN p8418k74q1b 10 14 and and CCONJ p8418k74q1b 10 15 threonine threonine NOUN p8418k74q1b 10 16 ( ( PUNCT p8418k74q1b 10 17 ser ser NOUN p8418k74q1b 10 18 / / SYM p8418k74q1b 10 19 thr thr NOUN p8418k74q1b 10 20 ) ) PUNCT p8418k74q1b 10 21 residues residue NOUN p8418k74q1b 10 22 . . PUNCT p8418k74q1b 11 1 using use VERB p8418k74q1b 11 2 bioinformatics bioinformatic NOUN p8418k74q1b 11 3 and and CCONJ p8418k74q1b 11 4 in in ADP p8418k74q1b 11 5 silico silico NOUN p8418k74q1b 11 6 analysis analysis NOUN p8418k74q1b 11 7 we we PRON p8418k74q1b 11 8 identified identify VERB p8418k74q1b 11 9 protein protein NOUN p8418k74q1b 11 10 phosphatase phosphatase NOUN p8418k74q1b 11 11 5 5 NUM p8418k74q1b 11 12 ( ( PUNCT p8418k74q1b 11 13 pp5 pp5 NOUN p8418k74q1b 11 14 ) ) PUNCT p8418k74q1b 11 15 , , PUNCT p8418k74q1b 11 16 a a DET p8418k74q1b 11 17 ser ser NOUN p8418k74q1b 11 18 / / SYM p8418k74q1b 11 19 thr thr NOUN p8418k74q1b 11 20 phosphatase phosphatase NOUN p8418k74q1b 11 21 belonging belong VERB p8418k74q1b 11 22 to to ADP p8418k74q1b 11 23 the the DET p8418k74q1b 11 24 ppp ppp NOUN p8418k74q1b 11 25 family family NOUN p8418k74q1b 11 26 of of ADP p8418k74q1b 11 27 phosphatases phosphatase NOUN p8418k74q1b 11 28 . . PUNCT p8418k74q1b 12 1 pp5 pp5 NOUN p8418k74q1b 12 2 is be AUX p8418k74q1b 12 3 unique unique ADJ p8418k74q1b 12 4 in in SCONJ p8418k74q1b 12 5 that that SCONJ p8418k74q1b 12 6 it it PRON p8418k74q1b 12 7 differs differ VERB p8418k74q1b 12 8 from from ADP p8418k74q1b 12 9 other other ADJ p8418k74q1b 12 10 phosphatases phosphatase NOUN p8418k74q1b 12 11 in in ADP p8418k74q1b 12 12 its its PRON p8418k74q1b 12 13 family family NOUN p8418k74q1b 12 14 due due ADP p8418k74q1b 12 15 to to ADP p8418k74q1b 12 16 its its PRON p8418k74q1b 12 17 n n ADJ p8418k74q1b 12 18 - - PUNCT p8418k74q1b 12 19 terminal terminal ADJ p8418k74q1b 12 20 tetratricopeptide tetratricopeptide ADJ p8418k74q1b 12 21 repeat repeat NOUN p8418k74q1b 12 22 ( ( PUNCT p8418k74q1b 12 23 tpr tpr PROPN p8418k74q1b 12 24 ) ) PUNCT p8418k74q1b 12 25 domains domain NOUN p8418k74q1b 12 26 , , PUNCT p8418k74q1b 12 27 which which PRON p8418k74q1b 12 28 are be AUX p8418k74q1b 12 29 momentous momentous ADJ p8418k74q1b 12 30 in in ADP p8418k74q1b 12 31 protein protein NOUN p8418k74q1b 12 32 - - PUNCT p8418k74q1b 12 33 protein protein NOUN p8418k74q1b 12 34 interactions interaction NOUN p8418k74q1b 12 35 and and CCONJ p8418k74q1b 12 36 auto auto NOUN p8418k74q1b 12 37 - - PUNCT p8418k74q1b 12 38 inhibition inhibition NOUN p8418k74q1b 12 39 . . PUNCT p8418k74q1b 13 1 upon upon SCONJ p8418k74q1b 13 2 investigation investigation NOUN p8418k74q1b 13 3 , , PUNCT p8418k74q1b 13 4 recombinant recombinant ADJ p8418k74q1b 13 5 pp5 pp5 NOUN p8418k74q1b 13 6 proved prove VERB p8418k74q1b 13 7 it it PRON p8418k74q1b 13 8 to to PART p8418k74q1b 13 9 be be AUX p8418k74q1b 13 10 a a DET p8418k74q1b 13 11 bona bona ADJ p8418k74q1b 13 12 fide fide NOUN p8418k74q1b 13 13 phosphatase phosphatase NOUN p8418k74q1b 13 14 that that PRON p8418k74q1b 13 15 is be AUX p8418k74q1b 13 16 enzymatically enzymatically ADV p8418k74q1b 13 17 active active ADJ p8418k74q1b 13 18 . . PUNCT p8418k74q1b 14 1 further further ADJ p8418k74q1b 14 2 analysis analysis NOUN p8418k74q1b 14 3 showed show VERB p8418k74q1b 14 4 pp5 pp5 NOUN p8418k74q1b 14 5 to to PART p8418k74q1b 14 6 be be AUX p8418k74q1b 14 7 developmentally developmentally ADV p8418k74q1b 14 8 regulated regulate VERB p8418k74q1b 14 9 , , PUNCT p8418k74q1b 14 10 with with ADP p8418k74q1b 14 11 increased increase VERB p8418k74q1b 14 12 expression expression NOUN p8418k74q1b 14 13 in in ADP p8418k74q1b 14 14 metacyclic metacyclic ADJ p8418k74q1b 14 15 promastigotes promastigote NOUN p8418k74q1b 14 16 , , PUNCT p8418k74q1b 14 17 suggesting suggest VERB p8418k74q1b 14 18 a a DET p8418k74q1b 14 19 possible possible ADJ p8418k74q1b 14 20 role role NOUN p8418k74q1b 14 21 in in ADP p8418k74q1b 14 22 metacyclogenesis metacyclogenesis NOUN p8418k74q1b 14 23 . . PUNCT p8418k74q1b 15 1 the the DET p8418k74q1b 15 2 generation generation NOUN p8418k74q1b 15 3 of of ADP p8418k74q1b 15 4 pp5 pp5 NOUN p8418k74q1b 15 5 null null ADJ p8418k74q1b 15 6 mutant mutant ADJ p8418k74q1b 15 7 parasites parasite NOUN p8418k74q1b 15 8 revealed reveal VERB p8418k74q1b 15 9 that that SCONJ p8418k74q1b 15 10 despite despite SCONJ p8418k74q1b 15 11 its its PRON p8418k74q1b 15 12 inessentiality inessentiality NOUN p8418k74q1b 15 13 , , PUNCT p8418k74q1b 15 14 its its PRON p8418k74q1b 15 15 removal removal NOUN p8418k74q1b 15 16 significantly significantly ADV p8418k74q1b 15 17 decreases decrease VERB p8418k74q1b 15 18 parasite parasite NOUN p8418k74q1b 15 19 pathogenicity pathogenicity NOUN p8418k74q1b 15 20 which which PRON p8418k74q1b 15 21 , , PUNCT p8418k74q1b 15 22 therefore therefore ADV p8418k74q1b 15 23 , , PUNCT p8418k74q1b 15 24 further far ADV p8418k74q1b 15 25 implicates implicate VERB p8418k74q1b 15 26 its its PRON p8418k74q1b 15 27 potential potential ADJ p8418k74q1b 15 28 future future ADJ p8418k74q1b 15 29 applicability applicability NOUN p8418k74q1b 15 30 as as ADP p8418k74q1b 15 31 an an DET p8418k74q1b 15 32 anti anti ADJ p8418k74q1b 15 33 - - ADJ p8418k74q1b 15 34 parasitic parasitic ADJ p8418k74q1b 15 35 target target NOUN p8418k74q1b 15 36 . . PUNCT p8418k74q1b 16 1 altogether altogether ADV p8418k74q1b 16 2 , , PUNCT p8418k74q1b 16 3 this this DET p8418k74q1b 16 4 work work NOUN p8418k74q1b 16 5 demonstrates demonstrate VERB p8418k74q1b 16 6 the the DET p8418k74q1b 16 7 importance importance NOUN p8418k74q1b 16 8 of of ADP p8418k74q1b 16 9 studying study VERB p8418k74q1b 16 10 signal signal NOUN p8418k74q1b 16 11 transduction transduction NOUN p8418k74q1b 16 12 events event NOUN p8418k74q1b 16 13 for for ADP p8418k74q1b 16 14 the the DET p8418k74q1b 16 15 successful successful ADJ p8418k74q1b 16 16 development development NOUN p8418k74q1b 16 17 of of ADP p8418k74q1b 16 18 leishmania leishmania PROPN p8418k74q1b 16 19 - - PUNCT p8418k74q1b 16 20 based base VERB p8418k74q1b 16 21 therapeutics therapeutic NOUN p8418k74q1b 16 22 . . PUNCT