id sid tid token lemma pos pc289g58c1c 1 1 for for ADP pc289g58c1c 1 2 every every DET pc289g58c1c 1 3 breast breast NOUN pc289g58c1c 1 4 cancer cancer NOUN pc289g58c1c 1 5 detected detect VERB pc289g58c1c 1 6 by by ADP pc289g58c1c 1 7 screening screen VERB pc289g58c1c 1 8 mammography mammography NOUN pc289g58c1c 1 9 , , PUNCT pc289g58c1c 1 10 approximately approximately ADV pc289g58c1c 1 11 three three NUM pc289g58c1c 1 12 patients patient NOUN pc289g58c1c 1 13 undergo undergo VERB pc289g58c1c 1 14 biopsy biopsy PROPN pc289g58c1c 1 15 . . PUNCT pc289g58c1c 2 1 two two NUM pc289g58c1c 2 2 of of ADP pc289g58c1c 2 3 the the DET pc289g58c1c 2 4 three three NUM pc289g58c1c 2 5 biopsies biopsy NOUN pc289g58c1c 2 6 will will AUX pc289g58c1c 2 7 be be AUX pc289g58c1c 2 8 benign benign ADJ pc289g58c1c 2 9 , , PUNCT pc289g58c1c 2 10 resulting result VERB pc289g58c1c 2 11 in in ADP pc289g58c1c 2 12 unnecessary unnecessary ADJ pc289g58c1c 2 13 biopsies biopsy NOUN pc289g58c1c 2 14 particularly particularly ADV pc289g58c1c 2 15 in in ADP pc289g58c1c 2 16 women woman NOUN pc289g58c1c 2 17 with with ADP pc289g58c1c 2 18 dense dense ADJ pc289g58c1c 2 19 breast breast NOUN pc289g58c1c 2 20 tissue tissue NOUN pc289g58c1c 2 21 . . PUNCT pc289g58c1c 3 1 self self NOUN pc289g58c1c 3 2 - - PUNCT pc289g58c1c 3 3 referencing reference VERB pc289g58c1c 3 4 differential differential ADJ pc289g58c1c 3 5 spectroscopic spectroscopic ADJ pc289g58c1c 3 6 analysis analysis NOUN pc289g58c1c 3 7 ( ( PUNCT pc289g58c1c 3 8 srds srd NOUN pc289g58c1c 3 9 ) ) PUNCT pc289g58c1c 3 10 is be AUX pc289g58c1c 3 11 a a DET pc289g58c1c 3 12 promising promising ADJ pc289g58c1c 3 13 noninvasive noninvasive ADJ pc289g58c1c 3 14 optical optical ADJ pc289g58c1c 3 15 imaging imaging NOUN pc289g58c1c 3 16 approach approach NOUN pc289g58c1c 3 17 that that PRON pc289g58c1c 3 18 uses use VERB pc289g58c1c 3 19 functional functional ADJ pc289g58c1c 3 20 over over ADP pc289g58c1c 3 21 anatomic anatomic ADJ pc289g58c1c 3 22 characteristics characteristic NOUN pc289g58c1c 3 23 of of ADP pc289g58c1c 3 24 the the DET pc289g58c1c 3 25 tissue tissue NOUN pc289g58c1c 3 26 to to PART pc289g58c1c 3 27 differentiate differentiate VERB pc289g58c1c 3 28 benign benign ADJ pc289g58c1c 3 29 from from ADP pc289g58c1c 3 30 malignant malignant ADJ pc289g58c1c 3 31 lesions lesion NOUN pc289g58c1c 3 32 . . PUNCT pc289g58c1c 4 1 this this DET pc289g58c1c 4 2 method method NOUN pc289g58c1c 4 3 utilizes utilize VERB pc289g58c1c 4 4 high high ADJ pc289g58c1c 4 5 - - PUNCT pc289g58c1c 4 6 resolution resolution NOUN pc289g58c1c 4 7 spectroscopy spectroscopy NOUN pc289g58c1c 4 8 to to PART pc289g58c1c 4 9 quantify quantify VERB pc289g58c1c 4 10 the the DET pc289g58c1c 4 11 abundance abundance NOUN pc289g58c1c 4 12 of of ADP pc289g58c1c 4 13 tumor tumor NOUN pc289g58c1c 4 14 - - PUNCT pc289g58c1c 4 15 specific specific ADJ pc289g58c1c 4 16 molecules molecule NOUN pc289g58c1c 4 17 that that PRON pc289g58c1c 4 18 are be AUX pc289g58c1c 4 19 not not PART pc289g58c1c 4 20 present present ADJ pc289g58c1c 4 21 in in ADP pc289g58c1c 4 22 normal normal ADJ pc289g58c1c 4 23 breast breast NOUN pc289g58c1c 4 24 tissue tissue NOUN pc289g58c1c 4 25 . . PUNCT pc289g58c1c 5 1 diffuse diffuse VERB pc289g58c1c 5 2 optical optical ADJ pc289g58c1c 5 3 spectroscopic spectroscopic ADJ pc289g58c1c 5 4 imaging imaging NOUN pc289g58c1c 5 5 ( ( PUNCT pc289g58c1c 5 6 doi doi PROPN pc289g58c1c 5 7 ) ) PUNCT pc289g58c1c 5 8 has have AUX pc289g58c1c 5 9 shown show VERB pc289g58c1c 5 10 promise promise NOUN pc289g58c1c 5 11 in in ADP pc289g58c1c 5 12 performing perform VERB pc289g58c1c 5 13 srds srd NOUN pc289g58c1c 5 14 in in ADP pc289g58c1c 5 15 patients patient NOUN pc289g58c1c 5 16 to to PART pc289g58c1c 5 17 reveal reveal VERB pc289g58c1c 5 18 tumor tumor NOUN pc289g58c1c 5 19 - - PUNCT pc289g58c1c 5 20 specific specific ADJ pc289g58c1c 5 21 absorption absorption NOUN pc289g58c1c 5 22 signals signal NOUN pc289g58c1c 5 23 , , PUNCT pc289g58c1c 5 24 also also ADV pc289g58c1c 5 25 known know VERB pc289g58c1c 5 26 as as ADP pc289g58c1c 5 27 " " PUNCT pc289g58c1c 5 28 specific specific ADJ pc289g58c1c 5 29 tumor tumor NOUN pc289g58c1c 5 30 component component NOUN pc289g58c1c 5 31 " " PUNCT pc289g58c1c 5 32 ( ( PUNCT pc289g58c1c 5 33 stc stc NOUN pc289g58c1c 5 34 ) ) PUNCT pc289g58c1c 5 35 . . PUNCT pc289g58c1c 6 1 however however ADV pc289g58c1c 6 2 , , PUNCT pc289g58c1c 6 3 the the DET pc289g58c1c 6 4 origin origin NOUN pc289g58c1c 6 5 of of ADP pc289g58c1c 6 6 the the DET pc289g58c1c 6 7 stc stc NOUN pc289g58c1c 6 8 spectra spectra NOUN pc289g58c1c 6 9 remains remain VERB pc289g58c1c 6 10 unknown unknown ADJ pc289g58c1c 6 11 . . PUNCT pc289g58c1c 7 1 understanding understand VERB pc289g58c1c 7 2 the the DET pc289g58c1c 7 3 source source NOUN pc289g58c1c 7 4 of of ADP pc289g58c1c 7 5 the the DET pc289g58c1c 7 6 stc stc NOUN pc289g58c1c 7 7 spectrum spectrum NOUN pc289g58c1c 7 8 is be AUX pc289g58c1c 7 9 vital vital ADJ pc289g58c1c 7 10 to to PART pc289g58c1c 7 11 improve improve VERB pc289g58c1c 7 12 the the DET pc289g58c1c 7 13 stc stc NOUN pc289g58c1c 7 14 detection detection NOUN pc289g58c1c 7 15 and and CCONJ pc289g58c1c 7 16 ultimately ultimately ADV pc289g58c1c 7 17 achieve achieve VERB pc289g58c1c 7 18 higher high ADJ pc289g58c1c 7 19 diagnostic diagnostic ADJ pc289g58c1c 7 20 performance performance NOUN pc289g58c1c 7 21 . . PUNCT pc289g58c1c 8 1 this this DET pc289g58c1c 8 2 research research NOUN pc289g58c1c 8 3 comprises comprise VERB pc289g58c1c 8 4 two two NUM pc289g58c1c 8 5 major major ADJ pc289g58c1c 8 6 objectives objective NOUN pc289g58c1c 8 7 . . PUNCT pc289g58c1c 9 1 one one NUM pc289g58c1c 9 2 is be AUX pc289g58c1c 9 3 to to PART pc289g58c1c 9 4 determine determine VERB pc289g58c1c 9 5 the the DET pc289g58c1c 9 6 meaning meaning NOUN pc289g58c1c 9 7 of of ADP pc289g58c1c 9 8 the the DET pc289g58c1c 9 9 tumor tumor NOUN pc289g58c1c 9 10 specific specific ADJ pc289g58c1c 9 11 absorption absorption NOUN pc289g58c1c 9 12 signature signature NOUN pc289g58c1c 9 13 and and CCONJ pc289g58c1c 9 14 understand understand VERB pc289g58c1c 9 15 its its PRON pc289g58c1c 9 16 relation relation NOUN pc289g58c1c 9 17 to to ADP pc289g58c1c 9 18 the the DET pc289g58c1c 9 19 underlying underlie VERB pc289g58c1c 9 20 tumor tumor NOUN pc289g58c1c 9 21 containing contain VERB pc289g58c1c 9 22 tissue tissue NOUN pc289g58c1c 9 23 absorption absorption NOUN pc289g58c1c 9 24 . . PUNCT pc289g58c1c 10 1 the the DET pc289g58c1c 10 2 other other ADJ pc289g58c1c 10 3 objective objective NOUN pc289g58c1c 10 4 is be AUX pc289g58c1c 10 5 to to PART pc289g58c1c 10 6 deduce deduce VERB pc289g58c1c 10 7 methods method NOUN pc289g58c1c 10 8 to to PART pc289g58c1c 10 9 improve improve VERB pc289g58c1c 10 10 the the DET pc289g58c1c 10 11 detection detection NOUN pc289g58c1c 10 12 of of ADP pc289g58c1c 10 13 the the DET pc289g58c1c 10 14 tumor tumor NOUN pc289g58c1c 10 15 specific specific ADJ pc289g58c1c 10 16 absorption absorption NOUN pc289g58c1c 10 17 spectra spectra NOUN pc289g58c1c 10 18 as as ADV pc289g58c1c 10 19 well well ADV pc289g58c1c 10 20 as as ADP pc289g58c1c 10 21 improve improve VERB pc289g58c1c 10 22 the the DET pc289g58c1c 10 23 quantification quantification NOUN pc289g58c1c 10 24 of of ADP pc289g58c1c 10 25 major major ADJ pc289g58c1c 10 26 tissue tissue NOUN pc289g58c1c 10 27 constituents constituent NOUN pc289g58c1c 10 28 ( ( PUNCT pc289g58c1c 10 29 blood blood NOUN pc289g58c1c 10 30 , , PUNCT pc289g58c1c 10 31 water water NOUN pc289g58c1c 10 32 and and CCONJ pc289g58c1c 10 33 fat fat NOUN pc289g58c1c 10 34 ) ) PUNCT pc289g58c1c 10 35 , , PUNCT pc289g58c1c 10 36 and and CCONJ pc289g58c1c 10 37 thereby thereby ADV pc289g58c1c 10 38 improve improve VERB pc289g58c1c 10 39 breast breast NOUN pc289g58c1c 10 40 cancer cancer NOUN pc289g58c1c 10 41 diagnosis diagnosis NOUN pc289g58c1c 10 42 . . PUNCT pc289g58c1c 11 1 in in ADP pc289g58c1c 11 2 order order NOUN pc289g58c1c 11 3 to to PART pc289g58c1c 11 4 accomplish accomplish VERB pc289g58c1c 11 5 these these DET pc289g58c1c 11 6 objectives objective NOUN pc289g58c1c 11 7 , , PUNCT pc289g58c1c 11 8 we we PRON pc289g58c1c 11 9 have have AUX pc289g58c1c 11 10 developed develop VERB pc289g58c1c 11 11 a a DET pc289g58c1c 11 12 new new ADJ pc289g58c1c 11 13 hyperspectral hyperspectral ADJ pc289g58c1c 11 14 hybrid hybrid ADJ pc289g58c1c 11 15 frequency frequency NOUN pc289g58c1c 11 16 domain domain NOUN pc289g58c1c 11 17 ( ( PUNCT pc289g58c1c 11 18 fd fd PROPN pc289g58c1c 11 19 ) ) PUNCT pc289g58c1c 11 20 and and CCONJ pc289g58c1c 11 21 continuous continuous ADJ pc289g58c1c 11 22 wave wave NOUN pc289g58c1c 11 23 ( ( PUNCT pc289g58c1c 11 24 cw cw PROPN pc289g58c1c 11 25 ) ) PUNCT pc289g58c1c 11 26 diffuse diffuse VERB pc289g58c1c 11 27 optical optical ADJ pc289g58c1c 11 28 imaging imaging NOUN pc289g58c1c 11 29 ( ( PUNCT pc289g58c1c 11 30 hybrid hybrid PROPN pc289g58c1c 11 31 doi doi PROPN pc289g58c1c 11 32 ) ) PUNCT pc289g58c1c 11 33 technique technique NOUN pc289g58c1c 11 34 , , PUNCT pc289g58c1c 11 35 implemented implement VERB pc289g58c1c 11 36 with with ADP pc289g58c1c 11 37 a a DET pc289g58c1c 11 38 simple simple ADJ pc289g58c1c 11 39 probe probe NOUN pc289g58c1c 11 40 configuration configuration NOUN pc289g58c1c 11 41 , , PUNCT pc289g58c1c 11 42 to to PART pc289g58c1c 11 43 accurately accurately ADV pc289g58c1c 11 44 measure measure VERB pc289g58c1c 11 45 3d 3d DET pc289g58c1c 11 46 broadband broadband ADJ pc289g58c1c 11 47 optical optical ADJ pc289g58c1c 11 48 properties property NOUN pc289g58c1c 11 49 of of ADP pc289g58c1c 11 50 heterogeneous heterogeneous ADJ pc289g58c1c 11 51 turbid turbid ADJ pc289g58c1c 11 52 media medium NOUN pc289g58c1c 11 53 without without ADP pc289g58c1c 11 54 having have VERB pc289g58c1c 11 55 to to PART pc289g58c1c 11 56 employ employ VERB pc289g58c1c 11 57 spectral spectral ADJ pc289g58c1c 11 58 constraints constraint NOUN pc289g58c1c 11 59 . . PUNCT pc289g58c1c 12 1 we we PRON pc289g58c1c 12 2 simulated simulate VERB pc289g58c1c 12 3 the the DET pc289g58c1c 12 4 reconstruction reconstruction NOUN pc289g58c1c 12 5 of of ADP pc289g58c1c 12 6 absorption absorption NOUN pc289g58c1c 12 7 and and CCONJ pc289g58c1c 12 8 scattering scatter VERB pc289g58c1c 12 9 spectra spectra NOUN pc289g58c1c 12 10 ( ( PUNCT pc289g58c1c 12 11 650 650 NUM pc289g58c1c 12 12 – – PUNCT pc289g58c1c 12 13 1000 1000 NUM pc289g58c1c 12 14 nm nm NOUN pc289g58c1c 12 15 ) ) PUNCT pc289g58c1c 12 16 of of ADP pc289g58c1c 12 17 human human ADJ pc289g58c1c 12 18 breast breast NOUN pc289g58c1c 12 19 tumors tumor NOUN pc289g58c1c 12 20 in in ADP pc289g58c1c 12 21 a a DET pc289g58c1c 12 22 homogeneous homogeneous ADJ pc289g58c1c 12 23 background background NOUN pc289g58c1c 12 24 at at ADP pc289g58c1c 12 25 depths depth NOUN pc289g58c1c 12 26 of of ADP pc289g58c1c 12 27 0 0 NUM pc289g58c1c 12 28 to to ADP pc289g58c1c 12 29 10 10 NUM pc289g58c1c 12 30 mm mm PROPN pc289g58c1c 12 31 . . PUNCT pc289g58c1c 13 1 the the DET pc289g58c1c 13 2 hybrid hybrid PROPN pc289g58c1c 13 3 doi doi PROPN pc289g58c1c 13 4 technique technique NOUN pc289g58c1c 13 5 demonstrated demonstrate VERB pc289g58c1c 13 6 enhanced enhanced ADJ pc289g58c1c 13 7 performance performance NOUN pc289g58c1c 13 8 in in ADP pc289g58c1c 13 9 reconstruction reconstruction NOUN pc289g58c1c 13 10 of of ADP pc289g58c1c 13 11 optical optical ADJ pc289g58c1c 13 12 absorption absorption NOUN pc289g58c1c 13 13 with with ADP pc289g58c1c 13 14 a a DET pc289g58c1c 13 15 mean mean ADJ pc289g58c1c 13 16 accuracy accuracy NOUN pc289g58c1c 13 17 over over ADP pc289g58c1c 13 18 all all DET pc289g58c1c 13 19 71 71 NUM pc289g58c1c 13 20 wavelengths wavelength NOUN pc289g58c1c 13 21 of of ADP pc289g58c1c 13 22 8.39 8.39 NUM pc289g58c1c 13 23 % % NOUN pc289g58c1c 13 24 versus versus ADP pc289g58c1c 13 25 32.26 32.26 NUM pc289g58c1c 13 26 % % NOUN pc289g58c1c 13 27 for for ADP pc289g58c1c 13 28 a a DET pc289g58c1c 13 29 10 10 NUM pc289g58c1c 13 30 mm mm NOUN pc289g58c1c 13 31 deep deep ADJ pc289g58c1c 13 32 tumor tumor NOUN pc289g58c1c 13 33 with with ADP pc289g58c1c 13 34 the the DET pc289g58c1c 13 35 topographic topographic ADJ pc289g58c1c 13 36 doi doi PROPN pc289g58c1c 13 37 method method NOUN pc289g58c1c 13 38 . . PUNCT pc289g58c1c 14 1 the the DET pc289g58c1c 14 2 new new ADJ pc289g58c1c 14 3 hybrid hybrid ADJ pc289g58c1c 14 4 technique technique NOUN pc289g58c1c 14 5 was be AUX pc289g58c1c 14 6 also also ADV pc289g58c1c 14 7 tested test VERB pc289g58c1c 14 8 and and CCONJ pc289g58c1c 14 9 validated validate VERB pc289g58c1c 14 10 on on ADP pc289g58c1c 14 11 two two NUM pc289g58c1c 14 12 heterogeneous heterogeneous ADJ pc289g58c1c 14 13 tissue tissue NOUN pc289g58c1c 14 14 - - PUNCT pc289g58c1c 14 15 simulating simulate VERB pc289g58c1c 14 16 phantoms phantom NOUN pc289g58c1c 14 17 with with ADP pc289g58c1c 14 18 inclusion inclusion NOUN pc289g58c1c 14 19 depths depth NOUN pc289g58c1c 14 20 of of ADP pc289g58c1c 14 21 2 2 NUM pc289g58c1c 14 22 , , PUNCT pc289g58c1c 14 23 7 7 NUM pc289g58c1c 14 24 , , PUNCT pc289g58c1c 14 25 and and CCONJ pc289g58c1c 14 26 9 9 NUM pc289g58c1c 14 27 mm mm PROPN pc289g58c1c 14 28 . . PUNCT pc289g58c1c 15 1 the the DET pc289g58c1c 15 2 mean mean ADJ pc289g58c1c 15 3 optical optical ADJ pc289g58c1c 15 4 absorption absorption NOUN pc289g58c1c 15 5 accuracy accuracy NOUN pc289g58c1c 15 6 over over ADP pc289g58c1c 15 7 all all DET pc289g58c1c 15 8 wavelengths wavelength NOUN pc289g58c1c 15 9 was be AUX pc289g58c1c 15 10 similarly similarly ADV pc289g58c1c 15 11 improved improve VERB pc289g58c1c 15 12 up up ADP pc289g58c1c 15 13 to to ADP pc289g58c1c 15 14 5x 5x NOUN pc289g58c1c 15 15 for for ADP pc289g58c1c 15 16 the the DET pc289g58c1c 15 17 hybrid hybrid ADJ pc289g58c1c 15 18 doi doi PROPN pc289g58c1c 15 19 method method NOUN pc289g58c1c 15 20 versus versus ADP pc289g58c1c 15 21 topographic topographic ADJ pc289g58c1c 15 22 doi doi PROPN pc289g58c1c 15 23 for for SCONJ pc289g58c1c 15 24 the the DET pc289g58c1c 15 25 deepest deep ADJ pc289g58c1c 15 26 inclusions.the inclusions.the DET pc289g58c1c 15 27 srds srd NOUN pc289g58c1c 15 28 method method NOUN pc289g58c1c 15 29 was be AUX pc289g58c1c 15 30 evaluated evaluate VERB pc289g58c1c 15 31 by by ADP pc289g58c1c 15 32 extracting extract VERB pc289g58c1c 15 33 the the DET pc289g58c1c 15 34 stc stc NOUN pc289g58c1c 15 35 spectral spectral ADJ pc289g58c1c 15 36 absorption absorption NOUN pc289g58c1c 15 37 from from ADP pc289g58c1c 15 38 the the DET pc289g58c1c 15 39 broadband broadband NOUN pc289g58c1c 15 40 absorption absorption NOUN pc289g58c1c 15 41 spectra spectra NOUN pc289g58c1c 15 42 retrieved retrieve VERB pc289g58c1c 15 43 via via ADP pc289g58c1c 15 44 hybrid hybrid NOUN pc289g58c1c 15 45 and and CCONJ pc289g58c1c 15 46 conventional conventional ADJ pc289g58c1c 15 47 topographic topographic ADJ pc289g58c1c 15 48 doi doi PROPN pc289g58c1c 15 49 techniques technique NOUN pc289g58c1c 15 50 on on ADP pc289g58c1c 15 51 both both DET pc289g58c1c 15 52 computationally computationally ADV pc289g58c1c 15 53 modelled model VERB pc289g58c1c 15 54 and and CCONJ pc289g58c1c 15 55 phantom phantom ADJ pc289g58c1c 15 56 measured measure VERB pc289g58c1c 15 57 data datum NOUN pc289g58c1c 15 58 . . PUNCT pc289g58c1c 16 1 the the DET pc289g58c1c 16 2 computational computational ADJ pc289g58c1c 16 3 modelled model VERB pc289g58c1c 16 4 and and CCONJ pc289g58c1c 16 5 tissue tissue NOUN pc289g58c1c 16 6 - - PUNCT pc289g58c1c 16 7 simulating simulate VERB pc289g58c1c 16 8 phantom phantom NOUN pc289g58c1c 16 9 stc stc NOUN pc289g58c1c 16 10 results result NOUN pc289g58c1c 16 11 were be AUX pc289g58c1c 16 12 compared compare VERB pc289g58c1c 16 13 with with ADP pc289g58c1c 16 14 the the DET pc289g58c1c 16 15 known know VERB pc289g58c1c 16 16 underlying underlie VERB pc289g58c1c 16 17 tumor tumor NOUN pc289g58c1c 16 18 / / SYM pc289g58c1c 16 19 inclusion inclusion NOUN pc289g58c1c 16 20 specific specific ADJ pc289g58c1c 16 21 absorption absorption NOUN pc289g58c1c 16 22 spectra spectra NOUN pc289g58c1c 16 23 to to PART pc289g58c1c 16 24 reveal reveal VERB pc289g58c1c 16 25 that that SCONJ pc289g58c1c 16 26 the the DET pc289g58c1c 16 27 srds srd NOUN pc289g58c1c 16 28 approach approach NOUN pc289g58c1c 16 29 can can AUX pc289g58c1c 16 30 not not PART pc289g58c1c 16 31 establish establish VERB pc289g58c1c 16 32 quantitative quantitative ADJ pc289g58c1c 16 33 / / SYM pc289g58c1c 16 34 qualitative qualitative ADJ pc289g58c1c 16 35 accuracy accuracy NOUN pc289g58c1c 16 36 of of ADP pc289g58c1c 16 37 the the DET pc289g58c1c 16 38 true true ADJ pc289g58c1c 16 39 tumor tumor NOUN pc289g58c1c 16 40 specific specific ADJ pc289g58c1c 16 41 spectral spectral ADJ pc289g58c1c 16 42 absorption absorption NOUN pc289g58c1c 16 43 , , PUNCT pc289g58c1c 16 44 which which PRON pc289g58c1c 16 45 provided provide VERB pc289g58c1c 16 46 a a DET pc289g58c1c 16 47 new new ADJ pc289g58c1c 16 48 understanding understanding NOUN pc289g58c1c 16 49 about about ADP pc289g58c1c 16 50 the the DET pc289g58c1c 16 51 srds srd NOUN pc289g58c1c 16 52 method method NOUN pc289g58c1c 16 53 that that PRON pc289g58c1c 16 54 has have AUX pc289g58c1c 16 55 not not PART pc289g58c1c 16 56 been be AUX pc289g58c1c 16 57 previously previously ADV pc289g58c1c 16 58 reported report VERB pc289g58c1c 16 59 . . PUNCT pc289g58c1c 17 1 indeed indeed ADV pc289g58c1c 17 2 , , PUNCT pc289g58c1c 17 3 the the DET pc289g58c1c 17 4 stc stc NOUN pc289g58c1c 17 5 content content NOUN pc289g58c1c 17 6 indicates indicate VERB pc289g58c1c 17 7 more more ADJ pc289g58c1c 17 8 of of ADP pc289g58c1c 17 9 a a DET pc289g58c1c 17 10 spectral spectral ADJ pc289g58c1c 17 11 misfit misfit NOUN pc289g58c1c 17 12 between between ADP pc289g58c1c 17 13 the the DET pc289g58c1c 17 14 basis basis NOUN pc289g58c1c 17 15 chromophore chromophore NOUN pc289g58c1c 17 16 ( ( PUNCT pc289g58c1c 17 17 blood blood NOUN pc289g58c1c 17 18 , , PUNCT pc289g58c1c 17 19 water water NOUN pc289g58c1c 17 20 and and CCONJ pc289g58c1c 17 21 fat fat ADJ pc289g58c1c 17 22 ) ) PUNCT pc289g58c1c 17 23 contribution contribution NOUN pc289g58c1c 17 24 and and CCONJ pc289g58c1c 17 25 the the DET pc289g58c1c 17 26 tumor tumor NOUN pc289g58c1c 17 27 and and CCONJ pc289g58c1c 17 28 normal normal ADJ pc289g58c1c 17 29 difference difference NOUN pc289g58c1c 17 30 absorption absorption NOUN pc289g58c1c 17 31 , , PUNCT pc289g58c1c 17 32 which which PRON pc289g58c1c 17 33 implies imply VERB pc289g58c1c 17 34 the the DET pc289g58c1c 17 35 presence presence NOUN pc289g58c1c 17 36 of of ADP pc289g58c1c 17 37 other other ADJ pc289g58c1c 17 38 absorber absorber NOUN pc289g58c1c 17 39 / / SYM pc289g58c1c 17 40 absorbers absorber NOUN pc289g58c1c 17 41 that that PRON pc289g58c1c 17 42 are be AUX pc289g58c1c 17 43 unaccounted unaccounted ADJ pc289g58c1c 17 44 for for ADP pc289g58c1c 17 45 by by ADP pc289g58c1c 17 46 the the DET pc289g58c1c 17 47 major major ADJ pc289g58c1c 17 48 tissue tissue NOUN pc289g58c1c 17 49 absorbers absorber NOUN pc289g58c1c 17 50 . . PUNCT pc289g58c1c 18 1 keeping keep VERB pc289g58c1c 18 2 these these DET pc289g58c1c 18 3 observations observation NOUN pc289g58c1c 18 4 into into ADP pc289g58c1c 18 5 account account NOUN pc289g58c1c 18 6 , , PUNCT pc289g58c1c 18 7 we we PRON pc289g58c1c 18 8 investigated investigate VERB pc289g58c1c 18 9 the the DET pc289g58c1c 18 10 role role NOUN pc289g58c1c 18 11 of of ADP pc289g58c1c 18 12 minor minor ADJ pc289g58c1c 18 13 optical optical ADJ pc289g58c1c 18 14 absorbers absorber NOUN pc289g58c1c 18 15 such such ADJ pc289g58c1c 18 16 as as ADP pc289g58c1c 18 17 collagen collagen PROPN pc289g58c1c 18 18 and and CCONJ pc289g58c1c 18 19 methemoglobin methemoglobin PROPN pc289g58c1c 18 20 ( ( PUNCT pc289g58c1c 18 21 methb methb ADJ pc289g58c1c 18 22 ) ) PUNCT pc289g58c1c 18 23 in in ADP pc289g58c1c 18 24 distinguishing distinguish VERB pc289g58c1c 18 25 benign benign ADJ pc289g58c1c 18 26 and and CCONJ pc289g58c1c 18 27 malignant malignant ADJ pc289g58c1c 18 28 breast breast NOUN pc289g58c1c 18 29 lesions lesion NOUN pc289g58c1c 18 30 via via ADP pc289g58c1c 18 31 noninvasive noninvasive ADJ pc289g58c1c 18 32 quantitative quantitative ADJ pc289g58c1c 18 33 broadband broadband NOUN pc289g58c1c 18 34 doi.a doi.a NUM pc289g58c1c 18 35 total total NOUN pc289g58c1c 18 36 of of ADP pc289g58c1c 18 37 28 28 NUM pc289g58c1c 18 38 subjects subject NOUN pc289g58c1c 18 39 , , PUNCT pc289g58c1c 18 40 including include VERB pc289g58c1c 18 41 12 12 NUM pc289g58c1c 18 42 benign benign ADJ pc289g58c1c 18 43 and and CCONJ pc289g58c1c 18 44 18 18 NUM pc289g58c1c 18 45 malignant malignant ADJ pc289g58c1c 18 46 lesions lesion NOUN pc289g58c1c 18 47 ( ( PUNCT pc289g58c1c 18 48 birads birad VERB pc289g58c1c 18 49 score score NOUN pc289g58c1c 18 50 & & CCONJ pc289g58c1c 18 51 gt;= gt;= PROPN pc289g58c1c 18 52 3 3 NUM pc289g58c1c 18 53 ) ) PUNCT pc289g58c1c 18 54 were be AUX pc289g58c1c 18 55 optically optically ADV pc289g58c1c 18 56 characterized characterize VERB pc289g58c1c 18 57 in in ADP pc289g58c1c 18 58 terms term NOUN pc289g58c1c 18 59 of of ADP pc289g58c1c 18 60 oxy- oxy- ADJ pc289g58c1c 18 61 , , PUNCT pc289g58c1c 18 62 deoxyhemoglobin deoxyhemoglobin PROPN pc289g58c1c 18 63 , , PUNCT pc289g58c1c 18 64 water water NOUN pc289g58c1c 18 65 , , PUNCT pc289g58c1c 18 66 lipids lipid NOUN pc289g58c1c 18 67 , , PUNCT pc289g58c1c 18 68 collagen collagen PROPN pc289g58c1c 18 69 , , PUNCT pc289g58c1c 18 70 methb methb ADJ pc289g58c1c 18 71 and and CCONJ pc289g58c1c 18 72 scattering scatter VERB pc289g58c1c 18 73 parameters parameter NOUN pc289g58c1c 18 74 . . PUNCT pc289g58c1c 19 1 malignant malignant ADJ pc289g58c1c 19 2 lesions lesion NOUN pc289g58c1c 19 3 exhibited exhibit VERB pc289g58c1c 19 4 significantly significantly ADV pc289g58c1c 19 5 higher high ADJ pc289g58c1c 19 6 lesion lesion NOUN pc289g58c1c 19 7 to to ADP pc289g58c1c 19 8 normal normal ADJ pc289g58c1c 19 9 ratios ratio NOUN pc289g58c1c 19 10 of of ADP pc289g58c1c 19 11 oxy oxy ADJ pc289g58c1c 19 12 , , PUNCT pc289g58c1c 19 13 deoxyhemoglobin deoxyhemoglobin PROPN pc289g58c1c 19 14 , , PUNCT pc289g58c1c 19 15 water water NOUN pc289g58c1c 19 16 , , PUNCT pc289g58c1c 19 17 and and CCONJ pc289g58c1c 19 18 methb methb ADJ pc289g58c1c 19 19 compared compare VERB pc289g58c1c 19 20 to to ADP pc289g58c1c 19 21 benign benign ADJ pc289g58c1c 19 22 lesions lesion NOUN pc289g58c1c 19 23 . . PUNCT pc289g58c1c 20 1 amongst amongst ADP pc289g58c1c 20 2 all all DET pc289g58c1c 20 3 variables variable NOUN pc289g58c1c 20 4 considered consider VERB pc289g58c1c 20 5 , , PUNCT pc289g58c1c 20 6 only only ADV pc289g58c1c 20 7 methb methb ADJ pc289g58c1c 20 8 was be AUX pc289g58c1c 20 9 observed observe VERB pc289g58c1c 20 10 to to PART pc289g58c1c 20 11 be be AUX pc289g58c1c 20 12 significant significant ADJ pc289g58c1c 20 13 in in ADP pc289g58c1c 20 14 lesion lesion NOUN pc289g58c1c 20 15 discrimination discrimination NOUN pc289g58c1c 20 16 ( ( PUNCT pc289g58c1c 20 17 p p NOUN pc289g58c1c 20 18 = = NOUN pc289g58c1c 20 19 0.0016 0.0016 NUM pc289g58c1c 20 20 ) ) PUNCT pc289g58c1c 20 21 without without ADP pc289g58c1c 20 22 normalization normalization NOUN pc289g58c1c 20 23 to to ADP pc289g58c1c 20 24 healthy healthy ADJ pc289g58c1c 20 25 tissue tissue NOUN pc289g58c1c 20 26 . . PUNCT pc289g58c1c 21 1 although although SCONJ pc289g58c1c 21 2 the the DET pc289g58c1c 21 3 absolute absolute ADJ pc289g58c1c 21 4 concentration concentration NOUN pc289g58c1c 21 5 of of ADP pc289g58c1c 21 6 methb methb ADJ pc289g58c1c 21 7 is be AUX pc289g58c1c 21 8 small small ADJ pc289g58c1c 21 9 ( ( PUNCT pc289g58c1c 21 10 0.43±0.18 0.43±0.18 VERB pc289g58c1c 21 11 µm µm NOUN pc289g58c1c 21 12 for for ADP pc289g58c1c 21 13 benign benign NOUN pc289g58c1c 21 14 vs vs ADP pc289g58c1c 21 15 0.87±0.32 0.87±0.32 DET pc289g58c1c 21 16 µm µm NOUN pc289g58c1c 21 17 for for ADP pc289g58c1c 21 18 malignant malignant NOUN pc289g58c1c 21 19 ) ) PUNCT pc289g58c1c 21 20 , , PUNCT pc289g58c1c 21 21 the the DET pc289g58c1c 21 22 significance significance NOUN pc289g58c1c 21 23 of of ADP pc289g58c1c 21 24 the the DET pc289g58c1c 21 25 differences difference NOUN pc289g58c1c 21 26 is be AUX pc289g58c1c 21 27 the the DET pc289g58c1c 21 28 strongest strong ADJ pc289g58c1c 21 29 of of ADP pc289g58c1c 21 30 all all DET pc289g58c1c 21 31 the the DET pc289g58c1c 21 32 parameters parameter NOUN pc289g58c1c 21 33 investigated investigate VERB pc289g58c1c 21 34 . . PUNCT pc289g58c1c 22 1 the the DET pc289g58c1c 22 2 high high ADJ pc289g58c1c 22 3 methb methb ADJ pc289g58c1c 22 4 concentration concentration NOUN pc289g58c1c 22 5 observed observe VERB pc289g58c1c 22 6 in in ADP pc289g58c1c 22 7 malignant malignant ADJ pc289g58c1c 22 8 lesions lesion NOUN pc289g58c1c 22 9 compared compare VERB pc289g58c1c 22 10 to to ADP pc289g58c1c 22 11 benign benign ADJ pc289g58c1c 22 12 lesions lesion NOUN pc289g58c1c 22 13 reflects reflect VERB pc289g58c1c 22 14 the the DET pc289g58c1c 22 15 angiogenic angiogenic ADJ pc289g58c1c 22 16 state state NOUN pc289g58c1c 22 17 of of ADP pc289g58c1c 22 18 the the DET pc289g58c1c 22 19 lesions lesion NOUN pc289g58c1c 22 20 , , PUNCT pc289g58c1c 22 21 and and CCONJ pc289g58c1c 22 22 suggests suggest VERB pc289g58c1c 22 23 variations variation NOUN pc289g58c1c 22 24 in in ADP pc289g58c1c 22 25 the the DET pc289g58c1c 22 26 composition composition NOUN pc289g58c1c 22 27 of of ADP pc289g58c1c 22 28 malignant malignant ADJ pc289g58c1c 22 29 tissue tissue NOUN pc289g58c1c 22 30 such such ADJ pc289g58c1c 22 31 as as ADP pc289g58c1c 22 32 presence presence NOUN pc289g58c1c 22 33 of of ADP pc289g58c1c 22 34 neovascularization neovascularization NOUN pc289g58c1c 22 35 and and CCONJ pc289g58c1c 22 36 hemorrhage hemorrhage NOUN pc289g58c1c 22 37 . . PUNCT pc289g58c1c 23 1 the the DET pc289g58c1c 23 2 discriminatory discriminatory ADJ pc289g58c1c 23 3 power power NOUN pc289g58c1c 23 4 of of ADP pc289g58c1c 23 5 methb methb NOUN pc289g58c1c 23 6 for for ADP pc289g58c1c 23 7 distinguishing distinguish VERB pc289g58c1c 23 8 malignant malignant ADJ pc289g58c1c 23 9 and and CCONJ pc289g58c1c 23 10 benign benign ADJ pc289g58c1c 23 11 lesions lesion NOUN pc289g58c1c 23 12 , , PUNCT pc289g58c1c 23 13 also also ADV pc289g58c1c 23 14 shows show VERB pc289g58c1c 23 15 that that SCONJ pc289g58c1c 23 16 this this DET pc289g58c1c 23 17 minor minor ADJ pc289g58c1c 23 18 absorber absorber NOUN pc289g58c1c 23 19 was be AUX pc289g58c1c 23 20 partially partially ADV pc289g58c1c 23 21 responsible responsible ADJ pc289g58c1c 23 22 for for ADP pc289g58c1c 23 23 the the DET pc289g58c1c 23 24 greater great ADJ pc289g58c1c 23 25 magnitude magnitude NOUN pc289g58c1c 23 26 of of ADP pc289g58c1c 23 27 stc stc NOUN pc289g58c1c 23 28 spectral spectral ADJ pc289g58c1c 23 29 content content NOUN pc289g58c1c 23 30 in in ADP pc289g58c1c 23 31 malignant malignant ADJ pc289g58c1c 23 32 versus versus ADP pc289g58c1c 23 33 benign benign ADJ pc289g58c1c 23 34 lesions lesion NOUN pc289g58c1c 23 35 , , PUNCT pc289g58c1c 23 36 particularly particularly ADV pc289g58c1c 23 37 below below ADP pc289g58c1c 23 38 665 665 NUM pc289g58c1c 23 39 nm nm NOUN pc289g58c1c 23 40 and and CCONJ pc289g58c1c 23 41 above above ADP pc289g58c1c 23 42 960 960 NUM pc289g58c1c 23 43 nm nm NOUN pc289g58c1c 23 44 . . PUNCT pc289g58c1c 24 1 the the DET pc289g58c1c 24 2 biochemical biochemical ADJ pc289g58c1c 24 3 sources source NOUN pc289g58c1c 24 4 of of ADP pc289g58c1c 24 5 the the DET pc289g58c1c 24 6 other other ADJ pc289g58c1c 24 7 stc stc NOUN pc289g58c1c 24 8 spectral spectral ADJ pc289g58c1c 24 9 content content NOUN pc289g58c1c 24 10 ( ( PUNCT pc289g58c1c 24 11 665 665 NUM pc289g58c1c 24 12 nm nm NOUN pc289g58c1c 24 13 960 960 NUM pc289g58c1c 24 14 nm nm NOUN pc289g58c1c 24 15 ) ) PUNCT pc289g58c1c 24 16 are be AUX pc289g58c1c 24 17 yet yet ADV pc289g58c1c 24 18 to to PART pc289g58c1c 24 19 be be AUX pc289g58c1c 24 20 investigated investigate VERB pc289g58c1c 24 21 and and CCONJ pc289g58c1c 24 22 identified identify VERB pc289g58c1c 24 23 . . PUNCT pc289g58c1c 25 1 based base VERB pc289g58c1c 25 2 on on ADP pc289g58c1c 25 3 the the DET pc289g58c1c 25 4 results result NOUN pc289g58c1c 25 5 of of ADP pc289g58c1c 25 6 this this DET pc289g58c1c 25 7 study study NOUN pc289g58c1c 25 8 , , PUNCT pc289g58c1c 25 9 doi doi PROPN pc289g58c1c 25 10 - - PUNCT pc289g58c1c 25 11 measured measure VERB pc289g58c1c 25 12 methb methb NOUN pc289g58c1c 25 13 shows show VERB pc289g58c1c 25 14 significant significant ADJ pc289g58c1c 25 15 potential potential NOUN pc289g58c1c 25 16 in in ADP pc289g58c1c 25 17 non non ADJ pc289g58c1c 25 18 - - ADJ pc289g58c1c 25 19 invasive invasive ADJ pc289g58c1c 25 20 lesion lesion NOUN pc289g58c1c 25 21 characterization characterization NOUN pc289g58c1c 25 22 and and CCONJ pc289g58c1c 25 23 requires require VERB pc289g58c1c 25 24 further far ADV pc289g58c1c 25 25 investigation.in investigation.in X pc289g58c1c 25 26 summary summary VERB pc289g58c1c 25 27 , , PUNCT pc289g58c1c 25 28 a a DET pc289g58c1c 25 29 new new ADJ pc289g58c1c 25 30 hybrid hybrid ADJ pc289g58c1c 25 31 doi doi PROPN pc289g58c1c 25 32 method method NOUN pc289g58c1c 25 33 was be AUX pc289g58c1c 25 34 developed develop VERB pc289g58c1c 25 35 and and CCONJ pc289g58c1c 25 36 validated validate VERB pc289g58c1c 25 37 for for ADP pc289g58c1c 25 38 improved improved ADJ pc289g58c1c 25 39 broadband broadband ADJ pc289g58c1c 25 40 characterization characterization NOUN pc289g58c1c 25 41 of of ADP pc289g58c1c 25 42 deep deep ADJ pc289g58c1c 25 43 tissue tissue NOUN pc289g58c1c 25 44 inhomogeneities inhomogeneity NOUN pc289g58c1c 25 45 using use VERB pc289g58c1c 25 46 a a DET pc289g58c1c 25 47 simple simple ADJ pc289g58c1c 25 48 reflectance reflectance NOUN pc289g58c1c 25 49 - - PUNCT pc289g58c1c 25 50 based base VERB pc289g58c1c 25 51 probe probe NOUN pc289g58c1c 25 52 . . PUNCT pc289g58c1c 26 1 the the DET pc289g58c1c 26 2 srds srds PROPN pc289g58c1c 26 3 method method NOUN pc289g58c1c 26 4 was be AUX pc289g58c1c 26 5 evaluated evaluate VERB pc289g58c1c 26 6 on on ADP pc289g58c1c 26 7 computational computational ADJ pc289g58c1c 26 8 modelled model VERB pc289g58c1c 26 9 and and CCONJ pc289g58c1c 26 10 phantom phantom NOUN pc289g58c1c 26 11 measured measure VERB pc289g58c1c 26 12 broadband broadband NOUN pc289g58c1c 26 13 absorption absorption NOUN pc289g58c1c 26 14 to to PART pc289g58c1c 26 15 reveal reveal VERB pc289g58c1c 26 16 a a DET pc289g58c1c 26 17 new new ADJ pc289g58c1c 26 18 understanding understanding NOUN pc289g58c1c 26 19 of of ADP pc289g58c1c 26 20 the the DET pc289g58c1c 26 21 extracted extract VERB pc289g58c1c 26 22 stc stc NOUN pc289g58c1c 26 23 spectral spectral ADJ pc289g58c1c 26 24 absorption absorption NOUN pc289g58c1c 26 25 . . PUNCT pc289g58c1c 27 1 methemoglobin methemoglobin PROPN pc289g58c1c 27 2 was be AUX pc289g58c1c 27 3 identified identify VERB pc289g58c1c 27 4 as as ADP pc289g58c1c 27 5 one one NUM pc289g58c1c 27 6 of of ADP pc289g58c1c 27 7 the the DET pc289g58c1c 27 8 biochemical biochemical ADJ pc289g58c1c 27 9 sources source NOUN pc289g58c1c 27 10 of of ADP pc289g58c1c 27 11 stc stc NOUN pc289g58c1c 27 12 spectral spectral ADJ pc289g58c1c 27 13 contrast contrast NOUN pc289g58c1c 27 14 between between ADP pc289g58c1c 27 15 benign benign ADJ pc289g58c1c 27 16 and and CCONJ pc289g58c1c 27 17 malignant malignant ADJ pc289g58c1c 27 18 lesions lesion NOUN pc289g58c1c 27 19 , , PUNCT pc289g58c1c 27 20 and and CCONJ pc289g58c1c 27 21 for for ADP pc289g58c1c 27 22 the the DET pc289g58c1c 27 23 first first ADJ pc289g58c1c 27 24 time time NOUN pc289g58c1c 27 25 , , PUNCT pc289g58c1c 27 26 was be AUX pc289g58c1c 27 27 identified identify VERB pc289g58c1c 27 28 as as ADP pc289g58c1c 27 29 a a DET pc289g58c1c 27 30 potential potential ADJ pc289g58c1c 27 31 optical optical ADJ pc289g58c1c 27 32 biomarker biomarker NOUN pc289g58c1c 27 33 of of ADP pc289g58c1c 27 34 breast breast NOUN pc289g58c1c 27 35 malignancy malignancy NOUN pc289g58c1c 27 36 . . PUNCT