id	sid	tid	token	lemma	pos
r781wd40r61	1	1	the	the	DET
r781wd40r61	1	2	continued	continue	VERB
r781wd40r61	1	3	emergence	emergence	NOUN
r781wd40r61	1	4	of	of	ADP
r781wd40r61	1	5	multi	multi	ADJ
r781wd40r61	1	6	-	-	ADJ
r781wd40r61	1	7	drug	drug	ADJ
r781wd40r61	1	8	resistant	resistant	ADJ
r781wd40r61	1	9	(	(	PUNCT
r781wd40r61	1	10	mdr	mdr	PROPN
r781wd40r61	1	11	)	)	PUNCT
r781wd40r61	1	12	bacteria	bacteria	NOUN
r781wd40r61	1	13	is	be	AUX
r781wd40r61	1	14	a	a	DET
r781wd40r61	1	15	rising	rise	VERB
r781wd40r61	1	16	threat	threat	NOUN
r781wd40r61	1	17	to	to	ADP
r781wd40r61	1	18	global	global	ADJ
r781wd40r61	1	19	human	human	ADJ
r781wd40r61	1	20	health	health	NOUN
r781wd40r61	1	21	.	.	PUNCT
r781wd40r61	2	1	with	with	ADP
r781wd40r61	2	2	the	the	DET
r781wd40r61	2	3	discovery	discovery	NOUN
r781wd40r61	2	4	of	of	ADP
r781wd40r61	2	5	plasmid	plasmid	ADJ
r781wd40r61	2	6	borne	bear	VERB
r781wd40r61	2	7	resistance	resistance	NOUN
r781wd40r61	2	8	to	to	ADP
r781wd40r61	2	9	colistin	colistin	PROPN
r781wd40r61	2	10	found	find	VERB
r781wd40r61	2	11	in	in	ADP
r781wd40r61	2	12	2015	2015	NUM
r781wd40r61	2	13	,	,	PUNCT
r781wd40r61	2	14	the	the	DET
r781wd40r61	2	15	possibility	possibility	NOUN
r781wd40r61	2	16	of	of	ADP
r781wd40r61	2	17	bacterial	bacterial	ADJ
r781wd40r61	2	18	strains	strain	NOUN
r781wd40r61	2	19	with	with	ADP
r781wd40r61	2	20	pan	pan	ADJ
r781wd40r61	2	21	-	-	ADJ
r781wd40r61	2	22	antibiotic	antibiotic	ADJ
r781wd40r61	2	23	resistance	resistance	NOUN
r781wd40r61	2	24	became	become	VERB
r781wd40r61	2	25	a	a	DET
r781wd40r61	2	26	reality	reality	NOUN
r781wd40r61	2	27	.	.	PUNCT
r781wd40r61	3	1	due	due	ADP
r781wd40r61	3	2	to	to	ADP
r781wd40r61	3	3	financial	financial	ADJ
r781wd40r61	3	4	issues	issue	NOUN
r781wd40r61	3	5	,	,	PUNCT
r781wd40r61	3	6	most	most	ADV
r781wd40r61	3	7	large	large	ADJ
r781wd40r61	3	8	pharmaceutical	pharmaceutical	ADJ
r781wd40r61	3	9	companies	company	NOUN
r781wd40r61	3	10	have	have	AUX
r781wd40r61	3	11	all	all	PRON
r781wd40r61	3	12	but	but	ADV
r781wd40r61	3	13	abandoned	abandon	VERB
r781wd40r61	3	14	the	the	DET
r781wd40r61	3	15	development	development	NOUN
r781wd40r61	3	16	of	of	ADP
r781wd40r61	3	17	new	new	ADJ
r781wd40r61	3	18	antibiotics	antibiotic	NOUN
r781wd40r61	3	19	,	,	PUNCT
r781wd40r61	3	20	favoring	favor	VERB
r781wd40r61	3	21	research	research	NOUN
r781wd40r61	3	22	and	and	CCONJ
r781wd40r61	3	23	development	development	NOUN
r781wd40r61	3	24	on	on	ADP
r781wd40r61	3	25	treatments	treatment	NOUN
r781wd40r61	3	26	that	that	PRON
r781wd40r61	3	27	can	can	AUX
r781wd40r61	3	28	provide	provide	VERB
r781wd40r61	3	29	their	their	PRON
r781wd40r61	3	30	shareholders	shareholder	NOUN
r781wd40r61	3	31	greater	great	ADJ
r781wd40r61	3	32	returns	return	NOUN
r781wd40r61	3	33	on	on	ADP
r781wd40r61	3	34	investment	investment	NOUN
r781wd40r61	3	35	.	.	PUNCT
r781wd40r61	4	1	due	due	ADP
r781wd40r61	4	2	to	to	ADP
r781wd40r61	4	3	the	the	DET
r781wd40r61	4	4	lack	lack	NOUN
r781wd40r61	4	5	of	of	ADP
r781wd40r61	4	6	industrial	industrial	ADJ
r781wd40r61	4	7	interest	interest	NOUN
r781wd40r61	4	8	,	,	PUNCT
r781wd40r61	4	9	the	the	DET
r781wd40r61	4	10	challenges	challenge	NOUN
r781wd40r61	4	11	of	of	ADP
r781wd40r61	4	12	developing	develop	VERB
r781wd40r61	4	13	new	new	ADJ
r781wd40r61	4	14	antibiotics	antibiotic	NOUN
r781wd40r61	4	15	and	and	CCONJ
r781wd40r61	4	16	finding	find	VERB
r781wd40r61	4	17	alternative	alternative	ADJ
r781wd40r61	4	18	approaches	approach	NOUN
r781wd40r61	4	19	to	to	ADP
r781wd40r61	4	20	fighting	fight	VERB
r781wd40r61	4	21	multi	multi	ADJ
r781wd40r61	4	22	-	-	ADJ
r781wd40r61	4	23	drug	drug	ADJ
r781wd40r61	4	24	resistant	resistant	ADJ
r781wd40r61	4	25	bacterial	bacterial	ADJ
r781wd40r61	4	26	infections	infection	NOUN
r781wd40r61	4	27	have	have	AUX
r781wd40r61	4	28	fallen	fall	VERB
r781wd40r61	4	29	on	on	ADP
r781wd40r61	4	30	small	small	ADJ
r781wd40r61	4	31	startup	startup	NOUN
r781wd40r61	4	32	biopharmaceutical	biopharmaceutical	ADJ
r781wd40r61	4	33	companies	company	NOUN
r781wd40r61	4	34	and	and	CCONJ
r781wd40r61	4	35	academic	academic	ADJ
r781wd40r61	4	36	research	research	NOUN
r781wd40r61	4	37	groups	group	NOUN
r781wd40r61	4	38	.	.	PUNCT
r781wd40r61	5	1	herein	herein	ADV
r781wd40r61	5	2	,	,	PUNCT
r781wd40r61	5	3	two	two	NUM
r781wd40r61	5	4	alternative	alternative	ADJ
r781wd40r61	5	5	strategies	strategy	NOUN
r781wd40r61	5	6	to	to	ADP
r781wd40r61	5	7	developing	develop	VERB
r781wd40r61	5	8	novel	novel	NOUN
r781wd40r61	5	9	broad	broad	ADJ
r781wd40r61	5	10	-	-	PUNCT
r781wd40r61	5	11	spectrum	spectrum	NOUN
r781wd40r61	5	12	antibiotics	antibiotic	NOUN
r781wd40r61	5	13	will	will	AUX
r781wd40r61	5	14	be	be	AUX
r781wd40r61	5	15	discussed	discuss	VERB
r781wd40r61	5	16	:	:	PUNCT
r781wd40r61	5	17	antibiotic	antibiotic	ADJ
r781wd40r61	5	18	adjuvants	adjuvant	NOUN
r781wd40r61	5	19	and	and	CCONJ
r781wd40r61	5	20	small	small	ADJ
r781wd40r61	5	21	molecule	molecule	NOUN
r781wd40r61	5	22	virulence	virulence	NOUN
r781wd40r61	5	23	inhibitors.antibiotic	inhibitors.antibiotic	ADJ
r781wd40r61	5	24	adjuvants	adjuvant	NOUN
r781wd40r61	5	25	are	be	AUX
r781wd40r61	5	26	compounds	compound	NOUN
r781wd40r61	5	27	that	that	PRON
r781wd40r61	5	28	disrupt	disrupt	VERB
r781wd40r61	5	29	mechanisms	mechanism	NOUN
r781wd40r61	5	30	of	of	ADP
r781wd40r61	5	31	antibiotic	antibiotic	ADJ
r781wd40r61	5	32	resistance	resistance	NOUN
r781wd40r61	5	33	and	and	CCONJ
r781wd40r61	5	34	can	can	AUX
r781wd40r61	5	35	be	be	AUX
r781wd40r61	5	36	administered	administer	VERB
r781wd40r61	5	37	with	with	ADP
r781wd40r61	5	38	traditional	traditional	ADJ
r781wd40r61	5	39	antibiotics	antibiotic	NOUN
r781wd40r61	5	40	to	to	PART
r781wd40r61	5	41	provide	provide	VERB
r781wd40r61	5	42	a	a	DET
r781wd40r61	5	43	powerful	powerful	ADJ
r781wd40r61	5	44	combination	combination	NOUN
r781wd40r61	5	45	treatment	treatment	NOUN
r781wd40r61	5	46	to	to	ADP
r781wd40r61	5	47	combat	combat	VERB
r781wd40r61	5	48	mdr	mdr	NOUN
r781wd40r61	5	49	bacteria	bacteria	NOUN
r781wd40r61	5	50	.	.	PUNCT
r781wd40r61	6	1	one	one	NUM
r781wd40r61	6	2	example	example	NOUN
r781wd40r61	6	3	of	of	ADP
r781wd40r61	6	4	adjuvants	adjuvant	NOUN
r781wd40r61	6	5	are	be	AUX
r781wd40r61	6	6	compounds	compound	NOUN
r781wd40r61	6	7	that	that	PRON
r781wd40r61	6	8	can	can	AUX
r781wd40r61	6	9	disrupt	disrupt	VERB
r781wd40r61	6	10	biofilms	biofilm	NOUN
r781wd40r61	6	11	.	.	PUNCT
r781wd40r61	7	1	biofilms	biofilm	NOUN
r781wd40r61	7	2	are	be	AUX
r781wd40r61	7	3	highly	highly	ADV
r781wd40r61	7	4	organized	organize	VERB
r781wd40r61	7	5	surface	surface	NOUN
r781wd40r61	7	6	associated	associate	VERB
r781wd40r61	7	7	communities	community	NOUN
r781wd40r61	7	8	encased	encase	VERB
r781wd40r61	7	9	within	within	ADP
r781wd40r61	7	10	an	an	DET
r781wd40r61	7	11	extracellular	extracellular	ADJ
r781wd40r61	7	12	polymeric	polymeric	ADJ
r781wd40r61	7	13	substance	substance	NOUN
r781wd40r61	7	14	(	(	PUNCT
r781wd40r61	7	15	eps	eps	X
r781wd40r61	7	16	)	)	PUNCT
r781wd40r61	7	17	which	which	PRON
r781wd40r61	7	18	can	can	AUX
r781wd40r61	7	19	afford	afford	VERB
r781wd40r61	7	20	the	the	DET
r781wd40r61	7	21	bacteria	bacteria	NOUN
r781wd40r61	7	22	up	up	ADV
r781wd40r61	7	23	to	to	PART
r781wd40r61	7	24	1000	1000	NUM
r781wd40r61	7	25	-	-	ADJ
r781wd40r61	7	26	fold	fold	VERB
r781wd40r61	7	27	increases	increase	NOUN
r781wd40r61	7	28	in	in	ADP
r781wd40r61	7	29	resistance	resistance	NOUN
r781wd40r61	7	30	to	to	ADP
r781wd40r61	7	31	antibiotics	antibiotic	NOUN
r781wd40r61	7	32	.	.	PUNCT
r781wd40r61	8	1	by	by	ADP
r781wd40r61	8	2	either	either	CCONJ
r781wd40r61	8	3	inhibiting	inhibit	VERB
r781wd40r61	8	4	biofilm	biofilm	NOUN
r781wd40r61	8	5	formation	formation	NOUN
r781wd40r61	8	6	or	or	CCONJ
r781wd40r61	8	7	dispersing	disperse	VERB
r781wd40r61	8	8	pre	pre	ADJ
r781wd40r61	8	9	-	-	ADJ
r781wd40r61	8	10	formed	formed	ADJ
r781wd40r61	8	11	biofilms	biofilm	NOUN
r781wd40r61	8	12	,	,	PUNCT
r781wd40r61	8	13	adjuvants	adjuvant	NOUN
r781wd40r61	8	14	can	can	AUX
r781wd40r61	8	15	allow	allow	VERB
r781wd40r61	8	16	antibiotics	antibiotic	NOUN
r781wd40r61	8	17	to	to	PART
r781wd40r61	8	18	eradicate	eradicate	VERB
r781wd40r61	8	19	infections	infection	NOUN
r781wd40r61	8	20	more	more	ADV
r781wd40r61	8	21	effectively	effectively	ADV
r781wd40r61	8	22	.	.	PUNCT
r781wd40r61	9	1	additionally	additionally	ADV
r781wd40r61	9	2	,	,	PUNCT
r781wd40r61	9	3	adjuvants	adjuvant	NOUN
r781wd40r61	9	4	that	that	PRON
r781wd40r61	9	5	are	be	AUX
r781wd40r61	9	6	capable	capable	ADJ
r781wd40r61	9	7	of	of	ADP
r781wd40r61	9	8	reversing	reverse	VERB
r781wd40r61	9	9	colistin	colistin	PROPN
r781wd40r61	9	10	resistance	resistance	PROPN
r781wd40r61	9	11	offer	offer	VERB
r781wd40r61	9	12	the	the	DET
r781wd40r61	9	13	possibility	possibility	NOUN
r781wd40r61	9	14	of	of	ADP
r781wd40r61	9	15	decreased	decrease	VERB
r781wd40r61	9	16	antibiotic	antibiotic	ADJ
r781wd40r61	9	17	resistance	resistance	NOUN
r781wd40r61	9	18	evolution	evolution	NOUN
r781wd40r61	9	19	while	while	SCONJ
r781wd40r61	9	20	also	also	ADV
r781wd40r61	9	21	allowing	allow	VERB
r781wd40r61	9	22	physicians	physician	NOUN
r781wd40r61	9	23	continued	continue	VERB
r781wd40r61	9	24	use	use	NOUN
r781wd40r61	9	25	of	of	ADP
r781wd40r61	9	26	colistin	colistin	PROPN
r781wd40r61	9	27	as	as	ADP
r781wd40r61	9	28	the	the	DET
r781wd40r61	9	29	antibiotic	antibiotic	NOUN
r781wd40r61	9	30	of	of	ADP
r781wd40r61	9	31	last	last	ADJ
r781wd40r61	9	32	resort	resort	NOUN
r781wd40r61	9	33	against	against	ADP
r781wd40r61	9	34	mdr	mdr	NOUN
r781wd40r61	9	35	gramnegative	gramnegative	ADJ
r781wd40r61	9	36	infections	infection	NOUN
r781wd40r61	9	37	.	.	PUNCT
r781wd40r61	10	1	small	small	ADJ
r781wd40r61	10	2	molecule	molecule	NOUN
r781wd40r61	10	3	virulence	virulence	NOUN
r781wd40r61	10	4	inhibitors	inhibitor	NOUN
r781wd40r61	10	5	are	be	AUX
r781wd40r61	10	6	small	small	ADJ
r781wd40r61	10	7	molecules	molecule	NOUN
r781wd40r61	10	8	that	that	PRON
r781wd40r61	10	9	are	be	AUX
r781wd40r61	10	10	nontoxic	nontoxic	ADJ
r781wd40r61	10	11	to	to	ADP
r781wd40r61	10	12	the	the	DET
r781wd40r61	10	13	bacteria	bacteria	NOUN
r781wd40r61	10	14	but	but	CCONJ
r781wd40r61	10	15	prevent	prevent	VERB
r781wd40r61	10	16	the	the	DET
r781wd40r61	10	17	secretion	secretion	NOUN
r781wd40r61	10	18	of	of	ADP
r781wd40r61	10	19	virulence	virulence	NOUN
r781wd40r61	10	20	factors	factor	NOUN
r781wd40r61	10	21	.	.	PUNCT
r781wd40r61	11	1	by	by	ADP
r781wd40r61	11	2	selectively	selectively	ADV
r781wd40r61	11	3	inhibiting	inhibit	VERB
r781wd40r61	11	4	nonessential	nonessential	ADJ
r781wd40r61	11	5	signaling	signal	VERB
r781wd40r61	11	6	pathways	pathway	NOUN
r781wd40r61	11	7	such	such	ADJ
r781wd40r61	11	8	as	as	ADP
r781wd40r61	11	9	two	two	NUM
r781wd40r61	11	10	-	-	PUNCT
r781wd40r61	11	11	component	component	NOUN
r781wd40r61	11	12	systems	system	NOUN
r781wd40r61	11	13	,	,	PUNCT
r781wd40r61	11	14	virulence	virulence	NOUN
r781wd40r61	11	15	inhibitors	inhibitor	NOUN
r781wd40r61	11	16	can	can	AUX
r781wd40r61	11	17	prevent	prevent	VERB
r781wd40r61	11	18	increased	increase	VERB
r781wd40r61	11	19	incidence	incidence	NOUN
r781wd40r61	11	20	of	of	ADP
r781wd40r61	11	21	resistance	resistance	NOUN
r781wd40r61	11	22	and	and	CCONJ
r781wd40r61	11	23	weaken	weaken	VERB
r781wd40r61	11	24	bacteria	bacteria	NOUN
r781wd40r61	11	25	allowing	allow	VERB
r781wd40r61	11	26	the	the	DET
r781wd40r61	11	27	host	host	NOUN
r781wd40r61	11	28	's	's	PART
r781wd40r61	11	29	immune	immune	ADJ
r781wd40r61	11	30	system	system	NOUN
r781wd40r61	11	31	to	to	PART
r781wd40r61	11	32	clear	clear	VERB
r781wd40r61	11	33	infections	infection	NOUN
r781wd40r61	11	34	without	without	ADP
r781wd40r61	11	35	additional	additional	ADJ
r781wd40r61	11	36	antibacterial	antibacterial	ADJ
r781wd40r61	11	37	agents	agent	NOUN
r781wd40r61	11	38	.	.	PUNCT
r781wd40r61	12	1	this	this	DET
r781wd40r61	12	2	manuscript	manuscript	NOUN
r781wd40r61	12	3	discusses	discuss	VERB
r781wd40r61	12	4	the	the	DET
r781wd40r61	12	5	synthesis	synthesis	NOUN
r781wd40r61	12	6	and	and	CCONJ
r781wd40r61	12	7	testing	testing	NOUN
r781wd40r61	12	8	of	of	ADP
r781wd40r61	12	9	compounds	compound	NOUN
r781wd40r61	12	10	that	that	PRON
r781wd40r61	12	11	show	show	VERB
r781wd40r61	12	12	antibiofilm	antibiofilm	NOUN
r781wd40r61	12	13	activity	activity	NOUN
r781wd40r61	12	14	against	against	ADP
r781wd40r61	12	15	methicillin	methicillin	PROPN
r781wd40r61	12	16	resistant	resistant	ADJ
r781wd40r61	12	17	staphylococcus	staphylococcus	PROPN
r781wd40r61	12	18	aureus	aureus	PROPN
r781wd40r61	12	19	(	(	PUNCT
r781wd40r61	12	20	mrsa	mrsa	PROPN
r781wd40r61	12	21	)	)	PUNCT
r781wd40r61	12	22	and	and	CCONJ
r781wd40r61	12	23	colistin	colistin	PROPN
r781wd40r61	12	24	potentiation	potentiation	NOUN
r781wd40r61	12	25	against	against	ADP
r781wd40r61	12	26	colistin	colistin	PROPN
r781wd40r61	12	27	resistant	resistant	ADJ
r781wd40r61	12	28	strains	strain	NOUN
r781wd40r61	12	29	of	of	ADP
r781wd40r61	12	30	klebsiella	klebsiella	PROPN
r781wd40r61	12	31	pneumonia	pneumonia	PROPN
r781wd40r61	12	32	and	and	CCONJ
r781wd40r61	12	33	acinetobacter	acinetobacter	ADJ
r781wd40r61	12	34	baumannii	baumannii	NOUN
r781wd40r61	12	35	.	.	PUNCT
r781wd40r61	13	1	furthermore	furthermore	ADV
r781wd40r61	13	2	,	,	PUNCT
r781wd40r61	13	3	two	two	NUM
r781wd40r61	13	4	sets	set	NOUN
r781wd40r61	13	5	of	of	ADP
r781wd40r61	13	6	compounds	compound	NOUN
r781wd40r61	13	7	are	be	AUX
r781wd40r61	13	8	presented	present	VERB
r781wd40r61	13	9	that	that	SCONJ
r781wd40r61	13	10	inhibit	inhibit	VERB
r781wd40r61	13	11	a	a	DET
r781wd40r61	13	12	global	global	ADJ
r781wd40r61	13	13	virulence	virulence	NOUN
r781wd40r61	13	14	signaling	signal	VERB
r781wd40r61	13	15	cascaded	cascade	VERB
r781wd40r61	13	16	in	in	ADP
r781wd40r61	13	17	s.	s.	PROPN
r781wd40r61	13	18	aureus	aureus	PROPN
r781wd40r61	13	19	,	,	PUNCT
r781wd40r61	13	20	one	one	NUM
r781wd40r61	13	21	of	of	ADP
r781wd40r61	13	22	which	which	PRON
r781wd40r61	13	23	is	be	AUX
r781wd40r61	13	24	also	also	ADV
r781wd40r61	13	25	able	able	ADJ
r781wd40r61	13	26	to	to	PART
r781wd40r61	13	27	potentiate	potentiate	VERB
r781wd40r61	13	28	the	the	DET
r781wd40r61	13	29	ß	ß	NUM
r781wd40r61	13	30	-	-	PUNCT
r781wd40r61	13	31	lactam	lactam	NOUN
r781wd40r61	13	32	oxacillin	oxacillin	NOUN
r781wd40r61	13	33	in	in	ADP
r781wd40r61	13	34	mrsa	mrsa	PROPN
r781wd40r61	13	35	.	.	PUNCT