id sid tid token lemma pos rj430289g0v 1 1 due due ADP rj430289g0v 1 2 to to ADP rj430289g0v 1 3 its its PRON rj430289g0v 1 4 public public ADJ rj430289g0v 1 5 health health NOUN rj430289g0v 1 6 impact impact NOUN rj430289g0v 1 7 as as ADP rj430289g0v 1 8 the the DET rj430289g0v 1 9 most most ADV rj430289g0v 1 10 important important ADJ rj430289g0v 1 11 vector vector NOUN rj430289g0v 1 12 of of ADP rj430289g0v 1 13 malaria malaria PROPN rj430289g0v 1 14 in in ADP rj430289g0v 1 15 africa africa PROPN rj430289g0v 1 16 , , PUNCT rj430289g0v 1 17 the the DET rj430289g0v 1 18 anopheles anophele NOUN rj430289g0v 1 19 gambiae gambiae NOUN rj430289g0v 1 20 mosquito mosquito PROPN rj430289g0v 1 21 and and CCONJ rj430289g0v 1 22 its its PRON rj430289g0v 1 23 plasmodium plasmodium NOUN rj430289g0v 1 24 parasites parasite NOUN rj430289g0v 1 25 have have AUX rj430289g0v 1 26 been be AUX rj430289g0v 1 27 the the DET rj430289g0v 1 28 subject subject NOUN rj430289g0v 1 29 of of ADP rj430289g0v 1 30 many many ADJ rj430289g0v 1 31 studies study NOUN rj430289g0v 1 32 both both CCONJ rj430289g0v 1 33 in in ADP rj430289g0v 1 34 the the DET rj430289g0v 1 35 laboratory laboratory NOUN rj430289g0v 1 36 and and CCONJ rj430289g0v 1 37 out out ADV rj430289g0v 1 38 in in ADP rj430289g0v 1 39 the the DET rj430289g0v 1 40 fields field NOUN rj430289g0v 1 41 . . PUNCT rj430289g0v 2 1 for for ADP rj430289g0v 2 2 successful successful ADJ rj430289g0v 2 3 transmission transmission NOUN rj430289g0v 2 4 of of ADP rj430289g0v 2 5 disease disease NOUN rj430289g0v 2 6 , , PUNCT rj430289g0v 2 7 the the DET rj430289g0v 2 8 parasites parasite NOUN rj430289g0v 2 9 must must AUX rj430289g0v 2 10 undergo undergo VERB rj430289g0v 2 11 a a DET rj430289g0v 2 12 period period NOUN rj430289g0v 2 13 of of ADP rj430289g0v 2 14 development development NOUN rj430289g0v 2 15 in in ADP rj430289g0v 2 16 the the DET rj430289g0v 2 17 mosquito mosquito NOUN rj430289g0v 2 18 from from ADP rj430289g0v 2 19 gametocytes gametocyte NOUN rj430289g0v 2 20 to to ADP rj430289g0v 2 21 sporozoites sporozoite NOUN rj430289g0v 2 22 . . PUNCT rj430289g0v 3 1 during during ADP rj430289g0v 3 2 this this DET rj430289g0v 3 3 period period NOUN rj430289g0v 3 4 , , PUNCT rj430289g0v 3 5 susceptibility susceptibility NOUN rj430289g0v 3 6 or or CCONJ rj430289g0v 3 7 refractoriness refractoriness NOUN rj430289g0v 3 8 is be AUX rj430289g0v 3 9 determined determine VERB rj430289g0v 3 10 by by ADP rj430289g0v 3 11 the the DET rj430289g0v 3 12 ability ability NOUN rj430289g0v 3 13 of of ADP rj430289g0v 3 14 some some DET rj430289g0v 3 15 mosquitoes mosquito NOUN rj430289g0v 3 16 to to PART rj430289g0v 3 17 encapsulate encapsulate VERB rj430289g0v 3 18 ookinetes ookinete NOUN rj430289g0v 3 19 in in ADP rj430289g0v 3 20 a a DET rj430289g0v 3 21 melanin melanin NOUN rj430289g0v 3 22 / / SYM rj430289g0v 3 23 protein protein NOUN rj430289g0v 3 24 matrix matrix NOUN rj430289g0v 3 25 following follow VERB rj430289g0v 3 26 their their PRON rj430289g0v 3 27 penetration penetration NOUN rj430289g0v 3 28 of of ADP rj430289g0v 3 29 the the DET rj430289g0v 3 30 midgut midgut NOUN rj430289g0v 3 31 epithelium epithelium NOUN rj430289g0v 3 32 . . PUNCT rj430289g0v 4 1 melanin melanin NOUN rj430289g0v 4 2 is be AUX rj430289g0v 4 3 deposited deposit VERB rj430289g0v 4 4 onto onto ADP rj430289g0v 4 5 the the DET rj430289g0v 4 6 surface surface NOUN rj430289g0v 4 7 of of ADP rj430289g0v 4 8 the the DET rj430289g0v 4 9 parasites parasite NOUN rj430289g0v 4 10 , , PUNCT rj430289g0v 4 11 causing cause VERB rj430289g0v 4 12 the the DET rj430289g0v 4 13 dead dead ADJ rj430289g0v 4 14 parasites parasite NOUN rj430289g0v 4 15 to to PART rj430289g0v 4 16 appear appear VERB rj430289g0v 4 17 brownish brownish ADJ rj430289g0v 4 18 black black NOUN rj430289g0v 4 19 . . PUNCT rj430289g0v 5 1 melanin melanin ADJ rj430289g0v 5 2 synthesis synthesis NOUN rj430289g0v 5 3 in in ADP rj430289g0v 5 4 insects insect NOUN rj430289g0v 5 5 involves involve VERB rj430289g0v 5 6 a a DET rj430289g0v 5 7 biochemical biochemical ADJ rj430289g0v 5 8 pathway pathway NOUN rj430289g0v 5 9 named name VERB rj430289g0v 5 10 after after ADP rj430289g0v 5 11 the the DET rj430289g0v 5 12 first first ADJ rj430289g0v 5 13 and and CCONJ rj430289g0v 5 14 most most ADV rj430289g0v 5 15 important important ADJ rj430289g0v 5 16 enzyme enzyme NOUN rj430289g0v 5 17 , , PUNCT rj430289g0v 5 18 phenoloxidase phenoloxidase NOUN rj430289g0v 5 19 ( ( PUNCT rj430289g0v 5 20 po po NOUN rj430289g0v 5 21 ) ) PUNCT rj430289g0v 5 22 . . PUNCT rj430289g0v 6 1 this this DET rj430289g0v 6 2 enzyme enzyme NOUN rj430289g0v 6 3 is be AUX rj430289g0v 6 4 synthesized synthesize VERB rj430289g0v 6 5 in in ADP rj430289g0v 6 6 an an DET rj430289g0v 6 7 inactive inactive ADJ rj430289g0v 6 8 form form NOUN rj430289g0v 6 9 and and CCONJ rj430289g0v 6 10 its its PRON rj430289g0v 6 11 activity activity NOUN rj430289g0v 6 12 depends depend VERB rj430289g0v 6 13 on on ADP rj430289g0v 6 14 proteolytic proteolytic ADJ rj430289g0v 6 15 activation activation NOUN rj430289g0v 6 16 by by ADP rj430289g0v 6 17 a a DET rj430289g0v 6 18 serine serine NOUN rj430289g0v 6 19 protease protease NOUN rj430289g0v 6 20 usually usually ADV rj430289g0v 6 21 called call VERB rj430289g0v 6 22 prophenoloxidase prophenoloxidase NOUN rj430289g0v 6 23 - - PUNCT rj430289g0v 6 24 activating activate VERB rj430289g0v 6 25 enzyme enzyme NOUN rj430289g0v 6 26 ( ( PUNCT rj430289g0v 6 27 ppae ppae NOUN rj430289g0v 6 28 ) ) PUNCT rj430289g0v 6 29 . . PUNCT rj430289g0v 7 1 this this DET rj430289g0v 7 2 serine serine NOUN rj430289g0v 7 3 protease protease NOUN rj430289g0v 7 4 has have VERB rj430289g0v 7 5 at at ADV rj430289g0v 7 6 least least ADV rj430289g0v 7 7 one one NUM rj430289g0v 7 8 extra extra ADJ rj430289g0v 7 9 domain domain NOUN rj430289g0v 7 10 called call VERB rj430289g0v 7 11 a a DET rj430289g0v 7 12 clip clip NOUN rj430289g0v 7 13 domain domain NOUN rj430289g0v 7 14 ( ( PUNCT rj430289g0v 7 15 jiang jiang PROPN rj430289g0v 7 16 and and CCONJ rj430289g0v 7 17 kanost kanost PROPN rj430289g0v 7 18 , , PUNCT rj430289g0v 7 19 2000 2000 NUM rj430289g0v 7 20 ) ) PUNCT rj430289g0v 7 21 . . PUNCT rj430289g0v 8 1 melanin melanin NOUN rj430289g0v 8 2 - - PUNCT rj430289g0v 8 3 associated associate VERB rj430289g0v 8 4 refractoriness refractoriness NOUN rj430289g0v 8 5 to to ADP rj430289g0v 8 6 the the DET rj430289g0v 8 7 primate primate ADJ rj430289g0v 8 8 parasite parasite NOUN rj430289g0v 8 9 p. p. PROPN rj430289g0v 8 10 cynomolgi cynomolgi PROPN rj430289g0v 8 11 b b PROPN rj430289g0v 8 12 and and CCONJ rj430289g0v 8 13 the the DET rj430289g0v 8 14 rodent rodent NOUN rj430289g0v 9 1 parasite parasite NOUN rj430289g0v 9 2 p. p. NOUN rj430289g0v 10 1 berghei berghei NOUN rj430289g0v 10 2 is be AUX rj430289g0v 10 3 influenced influence VERB rj430289g0v 10 4 by by ADP rj430289g0v 10 5 at at ADV rj430289g0v 10 6 least least ADV rj430289g0v 10 7 three three NUM rj430289g0v 10 8 quantitative quantitative ADJ rj430289g0v 10 9 trait trait NOUN rj430289g0v 10 10 loci locus NOUN rj430289g0v 10 11 ( ( PUNCT rj430289g0v 10 12 qtls qtls PROPN rj430289g0v 10 13 ) ) PUNCT rj430289g0v 10 14 . . PUNCT rj430289g0v 11 1 a a DET rj430289g0v 11 2 genetic genetic ADJ rj430289g0v 11 3 crossing crossing NOUN rj430289g0v 11 4 experiment experiment NOUN rj430289g0v 11 5 determined determine VERB rj430289g0v 11 6 that that SCONJ rj430289g0v 11 7 the the DET rj430289g0v 11 8 major major ADJ rj430289g0v 11 9 qtl qtl PROPN rj430289g0v 11 10 lies lie VERB rj430289g0v 11 11 on on ADP rj430289g0v 11 12 chromosome chromosome NOUN rj430289g0v 11 13 arm arm NOUN rj430289g0v 11 14 2r 2r NOUN rj430289g0v 11 15 between between ADP rj430289g0v 11 16 division division NOUN rj430289g0v 11 17 8c-8d 8c-8d NOUN rj430289g0v 11 18 and and CCONJ rj430289g0v 11 19 this this DET rj430289g0v 11 20 locus locus NOUN rj430289g0v 11 21 was be AUX rj430289g0v 11 22 named name VERB rj430289g0v 11 23 plasmodium plasmodium ADJ rj430289g0v 11 24 encapsulation encapsulation NOUN rj430289g0v 11 25 1 1 NUM rj430289g0v 11 26 ( ( PUNCT rj430289g0v 11 27 pen1 pen1 PROPN rj430289g0v 11 28 ) ) PUNCT rj430289g0v 11 29 to to PART rj430289g0v 11 30 reflect reflect VERB rj430289g0v 11 31 its its PRON rj430289g0v 11 32 major major ADJ rj430289g0v 11 33 role role NOUN rj430289g0v 11 34 in in ADP rj430289g0v 11 35 melanotic melanotic ADJ rj430289g0v 11 36 encapsulation encapsulation NOUN rj430289g0v 11 37 of of ADP rj430289g0v 11 38 parasites parasite NOUN rj430289g0v 11 39 ( ( PUNCT rj430289g0v 11 40 zheng zheng X rj430289g0v 11 41 et et PROPN rj430289g0v 11 42 al al PROPN rj430289g0v 11 43 . . PROPN rj430289g0v 11 44 , , PUNCT rj430289g0v 11 45 1997 1997 NUM rj430289g0v 11 46 ) ) PUNCT rj430289g0v 11 47 . . PUNCT rj430289g0v 12 1 this this DET rj430289g0v 12 2 thesis thesis NOUN rj430289g0v 12 3 describes describe VERB rj430289g0v 12 4 the the DET rj430289g0v 12 5 positional positional ADJ rj430289g0v 12 6 cloning cloning NOUN rj430289g0v 12 7 of of ADP rj430289g0v 12 8 pen1 pen1 NOUN rj430289g0v 12 9 from from ADP rj430289g0v 12 10 the the DET rj430289g0v 12 11 construction construction NOUN rj430289g0v 12 12 of of ADP rj430289g0v 12 13 a a DET rj430289g0v 12 14 physical physical ADJ rj430289g0v 12 15 map map NOUN rj430289g0v 12 16 to to ADP rj430289g0v 12 17 the the DET rj430289g0v 12 18 genomic genomic ADJ rj430289g0v 12 19 , , PUNCT rj430289g0v 12 20 bioinformatic bioinformatic ADJ rj430289g0v 12 21 , , PUNCT rj430289g0v 12 22 molecular molecular ADJ rj430289g0v 12 23 and and CCONJ rj430289g0v 12 24 functional functional ADJ rj430289g0v 12 25 analyses analysis NOUN rj430289g0v 12 26 supporting support VERB rj430289g0v 12 27 the the DET rj430289g0v 12 28 conclusion conclusion NOUN rj430289g0v 12 29 that that SCONJ rj430289g0v 12 30 pen1 pen1 PROPN rj430289g0v 12 31 encodes encode VERB rj430289g0v 12 32 a a DET rj430289g0v 12 33 clip clip NOUN rj430289g0v 12 34 domain domain NOUN rj430289g0v 12 35 serine serine NOUN rj430289g0v 12 36 protease protease NOUN rj430289g0v 12 37 with with ADP rj430289g0v 12 38 ppae ppae PROPN rj430289g0v 12 39 function function NOUN rj430289g0v 12 40 . . PUNCT rj430289g0v 13 1 specifically specifically ADV rj430289g0v 13 2 , , PUNCT rj430289g0v 13 3 we we PRON rj430289g0v 13 4 show show VERB rj430289g0v 13 5 that that SCONJ rj430289g0v 13 6 clipb17 clipb17 X rj430289g0v 13 7 is be AUX rj430289g0v 13 8 found find VERB rj430289g0v 13 9 within within ADP rj430289g0v 13 10 the the DET rj430289g0v 13 11 pen1 pen1 ADJ rj430289g0v 13 12 region region NOUN rj430289g0v 13 13 and and CCONJ rj430289g0v 13 14 that that SCONJ rj430289g0v 13 15 it it PRON rj430289g0v 13 16 encodes encode VERB rj430289g0v 13 17 a a DET rj430289g0v 13 18 serine serine NOUN rj430289g0v 13 19 protease protease NOUN rj430289g0v 13 20 with with ADP rj430289g0v 13 21 three three NUM rj430289g0v 13 22 clip clip NOUN rj430289g0v 13 23 domains domain NOUN rj430289g0v 13 24 and and CCONJ rj430289g0v 13 25 a a DET rj430289g0v 13 26 serine serine NOUN rj430289g0v 13 27 protease protease NOUN rj430289g0v 13 28 domain domain NOUN rj430289g0v 13 29 with with ADP rj430289g0v 13 30 sequence sequence NOUN rj430289g0v 13 31 similarity similarity NOUN rj430289g0v 13 32 to to ADP rj430289g0v 13 33 all all DET rj430289g0v 13 34 known know VERB rj430289g0v 13 35 ppaes ppae NOUN rj430289g0v 13 36 . . PUNCT rj430289g0v 14 1 in in ADP rj430289g0v 14 2 a a DET rj430289g0v 14 3 selected select VERB rj430289g0v 14 4 strain strain NOUN rj430289g0v 14 5 with with ADP rj430289g0v 14 6 a a DET rj430289g0v 14 7 fully fully ADV rj430289g0v 14 8 refractory refractory ADJ rj430289g0v 14 9 phenotype phenotype NOUN rj430289g0v 14 10 ( ( PUNCT rj430289g0v 14 11 l35 l35 PROPN rj430289g0v 14 12 strain strain NOUN rj430289g0v 14 13 ) ) PUNCT rj430289g0v 14 14 , , PUNCT rj430289g0v 14 15 clipb17 clipb17 SPACE rj430289g0v 14 16 gene gene NOUN rj430289g0v 14 17 expression expression NOUN rj430289g0v 14 18 is be AUX rj430289g0v 14 19 up up ADV rj430289g0v 14 20 - - PUNCT rj430289g0v 14 21 regulated regulate VERB rj430289g0v 14 22 at at ADP rj430289g0v 14 23 the the DET rj430289g0v 14 24 time time NOUN rj430289g0v 14 25 of of ADP rj430289g0v 14 26 parasite parasite PROPN rj430289g0v 14 27 melanization melanization PROPN rj430289g0v 14 28 . . PUNCT rj430289g0v 15 1 in in ADP rj430289g0v 15 2 the the DET rj430289g0v 15 3 counter counter ADJ rj430289g0v 15 4 - - ADJ rj430289g0v 15 5 selected select VERB rj430289g0v 15 6 strain strain NOUN rj430289g0v 15 7 4arr 4arr NUM rj430289g0v 15 8 , , PUNCT rj430289g0v 15 9 no no DET rj430289g0v 15 10 such such ADJ rj430289g0v 15 11 induction induction NOUN rj430289g0v 15 12 is be AUX rj430289g0v 15 13 evident evident ADJ rj430289g0v 15 14 . . PUNCT rj430289g0v 16 1 the the DET rj430289g0v 16 2 regulatory regulatory ADJ rj430289g0v 16 3 region region NOUN rj430289g0v 16 4 of of ADP rj430289g0v 16 5 clipb17 clipb17 X rj430289g0v 16 6 contains contain VERB rj430289g0v 16 7 multiple multiple ADJ rj430289g0v 16 8 strain strain NOUN rj430289g0v 16 9 - - PUNCT rj430289g0v 16 10 specific specific ADJ rj430289g0v 16 11 nucleotide nucleotide ADJ rj430289g0v 16 12 polymorphisms polymorphism NOUN rj430289g0v 16 13 clustered cluster VERB rj430289g0v 16 14 within within ADP rj430289g0v 16 15 three three NUM rj430289g0v 16 16 putative putative ADJ rj430289g0v 16 17 nf nf NOUN rj430289g0v 16 18 - - PUNCT rj430289g0v 16 19 kb kb NOUN rj430289g0v 16 20 sites site NOUN rj430289g0v 16 21 that that PRON rj430289g0v 16 22 could could AUX rj430289g0v 16 23 explain explain VERB rj430289g0v 16 24 the the DET rj430289g0v 16 25 l35 l35 PROPN rj430289g0v 16 26 - - PUNCT rj430289g0v 16 27 specific specific ADJ rj430289g0v 16 28 gene gene NOUN rj430289g0v 16 29 induction induction NOUN rj430289g0v 16 30 . . PUNCT rj430289g0v 17 1 we we PRON rj430289g0v 17 2 also also ADV rj430289g0v 17 3 show show VERB rj430289g0v 17 4 that that SCONJ rj430289g0v 17 5 rnai rnai ADJ rj430289g0v 17 6 knockdown knockdown NOUN rj430289g0v 17 7 abolishes abolish VERB rj430289g0v 17 8 clipb17 clipb17 X rj430289g0v 17 9 gene gene NOUN rj430289g0v 17 10 induction induction NOUN rj430289g0v 17 11 in in ADP rj430289g0v 17 12 l35 l35 PROPN rj430289g0v 17 13 and and CCONJ rj430289g0v 17 14 significantly significantly ADV rj430289g0v 17 15 reduces reduce VERB rj430289g0v 17 16 refractoriness refractoriness NOUN rj430289g0v 17 17 to to ADP rj430289g0v 17 18 both both PRON rj430289g0v 17 19 plasmodium plasmodium NOUN rj430289g0v 17 20 berghei berghei NOUN rj430289g0v 17 21 and and CCONJ rj430289g0v 17 22 p. p. PROPN rj430289g0v 17 23 cynomolgi cynomolgi PROPN rj430289g0v 17 24 b. b. PROPN rj430289g0v 17 25 melanotic melanotic PROPN rj430289g0v 17 26 encapsulation encapsulation NOUN rj430289g0v 17 27 represents represent VERB rj430289g0v 17 28 the the DET rj430289g0v 17 29 fastest fast ADJ rj430289g0v 17 30 and and CCONJ rj430289g0v 17 31 most most ADV rj430289g0v 17 32 important important ADJ rj430289g0v 17 33 endogenous endogenous ADJ rj430289g0v 17 34 refractory refractory ADJ rj430289g0v 17 35 mechanism mechanism NOUN rj430289g0v 17 36 against against ADP rj430289g0v 17 37 pathogens pathogen NOUN rj430289g0v 17 38 too too ADV rj430289g0v 17 39 large large ADJ rj430289g0v 17 40 or or CCONJ rj430289g0v 17 41 too too ADV rj430289g0v 17 42 numerous numerous ADJ rj430289g0v 17 43 for for ADP rj430289g0v 17 44 other other ADJ rj430289g0v 17 45 immune immune ADJ rj430289g0v 17 46 mechanisms mechanism NOUN rj430289g0v 17 47 to to PART rj430289g0v 17 48 cope cope VERB rj430289g0v 17 49 with with ADP rj430289g0v 17 50 ( ( PUNCT rj430289g0v 17 51 vey vey INTJ rj430289g0v 17 52 , , PUNCT rj430289g0v 17 53 1993 1993 NUM rj430289g0v 17 54 ) ) PUNCT rj430289g0v 17 55 . . PUNCT rj430289g0v 18 1 interest interest NOUN rj430289g0v 18 2 in in ADP rj430289g0v 18 3 this this DET rj430289g0v 18 4 immune immune ADJ rj430289g0v 18 5 mechanism mechanism NOUN rj430289g0v 18 6 as as SCONJ rj430289g0v 18 7 a a DET rj430289g0v 18 8 novel novel ADJ rj430289g0v 18 9 malaria malaria NOUN rj430289g0v 18 10 control control NOUN rj430289g0v 18 11 strategy strategy NOUN rj430289g0v 18 12 prompted prompt VERB rj430289g0v 18 13 its its PRON rj430289g0v 18 14 genetic genetic ADJ rj430289g0v 18 15 selection selection NOUN rj430289g0v 18 16 in in ADP rj430289g0v 18 17 a a DET rj430289g0v 18 18 laboratory laboratory NOUN rj430289g0v 18 19 strain strain NOUN rj430289g0v 18 20 . . PUNCT rj430289g0v 19 1 our our PRON rj430289g0v 19 2 determination determination NOUN rj430289g0v 19 3 of of ADP rj430289g0v 19 4 pen1 pen1 ADJ rj430289g0v 19 5 molecular molecular ADJ rj430289g0v 19 6 identity identity NOUN rj430289g0v 19 7 and and CCONJ rj430289g0v 19 8 function function NOUN rj430289g0v 19 9 significantly significantly ADV rj430289g0v 19 10 enhances enhance VERB rj430289g0v 19 11 the the DET rj430289g0v 19 12 future future ADJ rj430289g0v 19 13 prospect prospect NOUN rj430289g0v 19 14 to to PART rj430289g0v 19 15 explore explore VERB rj430289g0v 19 16 this this DET rj430289g0v 19 17 mechanism mechanism NOUN rj430289g0v 19 18 for for ADP rj430289g0v 19 19 controlling control VERB rj430289g0v 19 20 one one NUM rj430289g0v 19 21 of of ADP rj430289g0v 19 22 the the DET rj430289g0v 19 23 most most ADV rj430289g0v 19 24 devastating devastating ADJ rj430289g0v 19 25 diseases disease NOUN rj430289g0v 19 26 of of ADP rj430289g0v 19 27 man man NOUN rj430289g0v 19 28 . . PUNCT